id sid tid token lemma pos cord-263357-krvei97r 1 1 key key NN cord-263357-krvei97r 1 2 : : : cord-263357-krvei97r 1 3 cord-263357-krvei97r cord-263357-krvei97r NNP cord-263357-krvei97r 1 4 authors author NNS cord-263357-krvei97r 1 5 : : : cord-263357-krvei97r 1 6 Holmes Holmes NNP cord-263357-krvei97r 1 7 , , , cord-263357-krvei97r 1 8 Kathryn Kathryn NNP cord-263357-krvei97r 1 9 V. V. NNP cord-263357-krvei97r 1 10 ; ; : cord-263357-krvei97r 1 11 Dominguez Dominguez NNP cord-263357-krvei97r 1 12 , , , cord-263357-krvei97r 1 13 Samuel Samuel NNP cord-263357-krvei97r 1 14 R. R. NNP cord-263357-krvei97r 1 15 title title NN cord-263357-krvei97r 1 16 : : : cord-263357-krvei97r 1 17 The the DT cord-263357-krvei97r 1 18 New New NNP cord-263357-krvei97r 1 19 Age Age NNP cord-263357-krvei97r 1 20 of of IN cord-263357-krvei97r 1 21 Virus Virus NNP cord-263357-krvei97r 1 22 Discovery Discovery NNP cord-263357-krvei97r 1 23 : : : cord-263357-krvei97r 1 24 Genomic Genomic NNP cord-263357-krvei97r 1 25 Analysis Analysis NNP cord-263357-krvei97r 1 26 of of IN cord-263357-krvei97r 1 27 a a DT cord-263357-krvei97r 1 28 Novel Novel NNP cord-263357-krvei97r 1 29 Human Human NNP cord-263357-krvei97r 1 30 Betacoronavirus Betacoronavirus NNP cord-263357-krvei97r 1 31 Isolated isolate VBN cord-263357-krvei97r 1 32 from from IN cord-263357-krvei97r 1 33 a a DT cord-263357-krvei97r 1 34 Fatal fatal JJ cord-263357-krvei97r 1 35 Case case NN cord-263357-krvei97r 1 36 of of IN cord-263357-krvei97r 1 37 Pneumonia Pneumonia NNP cord-263357-krvei97r 1 38 date date NN cord-263357-krvei97r 1 39 : : : cord-263357-krvei97r 1 40 2013 2013 CD cord-263357-krvei97r 1 41 - - SYM cord-263357-krvei97r 1 42 01 01 CD cord-263357-krvei97r 1 43 - - HYPH cord-263357-krvei97r 1 44 08 08 CD cord-263357-krvei97r 1 45 journal journal NN cord-263357-krvei97r 1 46 : : : cord-263357-krvei97r 2 1 mBio mbio NN cord-263357-krvei97r 2 2 DOI doi NN cord-263357-krvei97r 2 3 : : : cord-263357-krvei97r 3 1 10.1128 10.1128 CD cord-263357-krvei97r 4 1 /mbio.00548 /mbio.00548 NNP cord-263357-krvei97r 4 2 - - HYPH cord-263357-krvei97r 4 3 12 12 CD cord-263357-krvei97r 4 4 sha sha NNP cord-263357-krvei97r 4 5 : : : cord-263357-krvei97r 5 1 5af9c3bce43b90c81887d5102c0e5c114d40f5dc 5af9c3bce43b90c81887d5102c0e5c114d40f5dc CD cord-263357-krvei97r 5 2 doc_id doc_id CD cord-263357-krvei97r 5 3 : : : cord-263357-krvei97r 5 4 263357 263357 CD cord-263357-krvei97r 5 5 cord_uid cord_uid NNS cord-263357-krvei97r 5 6 : : : cord-263357-krvei97r 5 7 krvei97r krvei97r NNP cord-263357-krvei97r 6 1 A a DT cord-263357-krvei97r 6 2 new new JJ cord-263357-krvei97r 6 3 human human JJ cord-263357-krvei97r 6 4 betacoronavirus betacoronavirus NN cord-263357-krvei97r 6 5 in in IN cord-263357-krvei97r 6 6 lineage lineage NN cord-263357-krvei97r 6 7 c c NNP cord-263357-krvei97r 6 8 , , , cord-263357-krvei97r 6 9 tentatively tentatively RB cord-263357-krvei97r 6 10 called call VBN cord-263357-krvei97r 6 11 HCoV HCoV NNP cord-263357-krvei97r 6 12 - - HYPH cord-263357-krvei97r 6 13 EMC EMC NNP cord-263357-krvei97r 6 14 , , , cord-263357-krvei97r 6 15 was be VBD cord-263357-krvei97r 6 16 isolated isolate VBN cord-263357-krvei97r 6 17 from from IN cord-263357-krvei97r 6 18 a a DT cord-263357-krvei97r 6 19 patient patient NN cord-263357-krvei97r 6 20 from from IN cord-263357-krvei97r 6 21 the the DT cord-263357-krvei97r 6 22 Kingdom Kingdom NNP cord-263357-krvei97r 6 23 of of IN cord-263357-krvei97r 6 24 Saudi Saudi NNP cord-263357-krvei97r 6 25 Arabia Arabia NNP cord-263357-krvei97r 6 26 who who WP cord-263357-krvei97r 6 27 died die VBD cord-263357-krvei97r 6 28 from from IN cord-263357-krvei97r 6 29 acute acute JJ cord-263357-krvei97r 6 30 severe severe JJ cord-263357-krvei97r 6 31 pneumonia pneumonia NN cord-263357-krvei97r 6 32 and and CC cord-263357-krvei97r 6 33 renal renal JJ cord-263357-krvei97r 6 34 failure failure NN cord-263357-krvei97r 6 35 . . . cord-263357-krvei97r 7 1 The the DT cord-263357-krvei97r 7 2 viral viral JJ cord-263357-krvei97r 7 3 RNA RNA NNP cord-263357-krvei97r 7 4 has have VBZ cord-263357-krvei97r 7 5 been be VBN cord-263357-krvei97r 7 6 detected detect VBN cord-263357-krvei97r 7 7 in in IN cord-263357-krvei97r 7 8 eight eight CD cord-263357-krvei97r 7 9 additional additional JJ cord-263357-krvei97r 7 10 cases case NNS cord-263357-krvei97r 7 11 . . . cord-263357-krvei97r 8 1 Sequencing sequencing NN cord-263357-krvei97r 8 2 and and CC cord-263357-krvei97r 8 3 bioinformatic bioinformatic JJ cord-263357-krvei97r 8 4 analysis analysis NN cord-263357-krvei97r 8 5 of of IN cord-263357-krvei97r 8 6 the the DT cord-263357-krvei97r 8 7 viral viral JJ cord-263357-krvei97r 8 8 genomic genomic JJ cord-263357-krvei97r 8 9 RNA RNA NNP cord-263357-krvei97r 8 10 showed show VBD cord-263357-krvei97r 8 11 that that IN cord-263357-krvei97r 8 12 it -PRON- PRP cord-263357-krvei97r 8 13 is be VBZ cord-263357-krvei97r 8 14 a a DT cord-263357-krvei97r 8 15 novel novel JJ cord-263357-krvei97r 8 16 virus virus NN cord-263357-krvei97r 8 17 not not RB cord-263357-krvei97r 8 18 previously previously RB cord-263357-krvei97r 8 19 detected detect VBN cord-263357-krvei97r 8 20 in in IN cord-263357-krvei97r 8 21 any any DT cord-263357-krvei97r 8 22 other other JJ cord-263357-krvei97r 8 23 species specie NNS cord-263357-krvei97r 8 24 and and CC cord-263357-krvei97r 8 25 that that IN cord-263357-krvei97r 8 26 its -PRON- PRP$ cord-263357-krvei97r 8 27 closest close JJS cord-263357-krvei97r 8 28 relatives relative NNS cord-263357-krvei97r 8 29 are be VBP cord-263357-krvei97r 8 30 two two CD cord-263357-krvei97r 8 31 Asian asian JJ cord-263357-krvei97r 8 32 bat bat NN cord-263357-krvei97r 8 33 coronaviruses coronaviruse NNS cord-263357-krvei97r 8 34 . . . cord-263357-krvei97r 9 1 HCoV HCoV NNP cord-263357-krvei97r 9 2 - - HYPH cord-263357-krvei97r 9 3 EMC EMC NNP cord-263357-krvei97r 9 4 may may MD cord-263357-krvei97r 9 5 represent represent VB cord-263357-krvei97r 9 6 a a DT cord-263357-krvei97r 9 7 sporadic sporadic JJ cord-263357-krvei97r 9 8 spillover spillover NN cord-263357-krvei97r 9 9 to to IN cord-263357-krvei97r 9 10 humans human NNS cord-263357-krvei97r 9 11 from from IN cord-263357-krvei97r 9 12 an an DT cord-263357-krvei97r 9 13 unknown unknown JJ cord-263357-krvei97r 9 14 animal animal NN cord-263357-krvei97r 9 15 reservoir reservoir NN cord-263357-krvei97r 9 16 . . . cord-263357-krvei97r 10 1 In in IN cord-263357-krvei97r 10 2 a a DT cord-263357-krvei97r 10 3 recent recent JJ cord-263357-krvei97r 10 4 article article NN cord-263357-krvei97r 10 5 , , , cord-263357-krvei97r 10 6 van van NNP cord-263357-krvei97r 10 7 Boheemen Boheemen NNP cord-263357-krvei97r 10 8 et et FW cord-263357-krvei97r 10 9 al al NNP cord-263357-krvei97r 10 10 . . NNP cord-263357-krvei97r 10 11 demonstrated demonstrate VBD cord-263357-krvei97r 10 12 how how WRB cord-263357-krvei97r 10 13 state state NN cord-263357-krvei97r 10 14 - - HYPH cord-263357-krvei97r 10 15 of of IN cord-263357-krvei97r 10 16 - - HYPH cord-263357-krvei97r 10 17 the the DT cord-263357-krvei97r 10 18 - - HYPH cord-263357-krvei97r 10 19 art art NN cord-263357-krvei97r 10 20 sequencing sequencing NN cord-263357-krvei97r 10 21 technology technology NN cord-263357-krvei97r 10 22 and and CC cord-263357-krvei97r 10 23 bioinformatic bioinformatic JJ cord-263357-krvei97r 10 24 analysis analysis NN cord-263357-krvei97r 10 25 can can MD cord-263357-krvei97r 10 26 quickly quickly RB cord-263357-krvei97r 10 27 provide provide VB cord-263357-krvei97r 10 28 critical critical JJ cord-263357-krvei97r 10 29 insight insight NN cord-263357-krvei97r 10 30 into into IN cord-263357-krvei97r 10 31 the the DT cord-263357-krvei97r 10 32 viral viral JJ cord-263357-krvei97r 10 33 genome genome NN cord-263357-krvei97r 10 34 sequence sequence NN cord-263357-krvei97r 10 35 , , , cord-263357-krvei97r 10 36 phylogeny phylogeny NN cord-263357-krvei97r 10 37 , , , cord-263357-krvei97r 10 38 replication replication NN cord-263357-krvei97r 10 39 strategy strategy NN cord-263357-krvei97r 10 40 , , , cord-263357-krvei97r 10 41 and and CC cord-263357-krvei97r 10 42 potential potential JJ cord-263357-krvei97r 10 43 drug drug NN cord-263357-krvei97r 10 44 and and CC cord-263357-krvei97r 10 45 vaccine vaccine NN cord-263357-krvei97r 10 46 targets target NNS cord-263357-krvei97r 10 47 and and CC cord-263357-krvei97r 10 48 generate generate VB cord-263357-krvei97r 10 49 tools tool NNS cord-263357-krvei97r 10 50 to to TO cord-263357-krvei97r 10 51 evaluate evaluate VB cord-263357-krvei97r 10 52 the the DT cord-263357-krvei97r 10 53 possible possible JJ cord-263357-krvei97r 10 54 epidemic epidemic NN cord-263357-krvei97r 10 55 risk risk NN cord-263357-krvei97r 10 56 associated associate VBN cord-263357-krvei97r 10 57 with with IN cord-263357-krvei97r 10 58 this this DT cord-263357-krvei97r 10 59 novel novel JJ cord-263357-krvei97r 10 60 human human JJ cord-263357-krvei97r 10 61 virus virus NN cord-263357-krvei97r 10 62 . . . cord-263357-krvei97r 11 1 D D NNP cord-263357-krvei97r 11 2 uring ure VBG cord-263357-krvei97r 11 3 the the DT cord-263357-krvei97r 11 4 past past JJ cord-263357-krvei97r 11 5 decade decade NN cord-263357-krvei97r 11 6 , , , cord-263357-krvei97r 11 7 at at IN cord-263357-krvei97r 11 8 least least JJS cord-263357-krvei97r 11 9 9 9 CD cord-263357-krvei97r 11 10 novel novel JJ cord-263357-krvei97r 11 11 human human JJ cord-263357-krvei97r 11 12 respiratory respiratory JJ cord-263357-krvei97r 11 13 viral viral JJ cord-263357-krvei97r 11 14 pathogens pathogen NNS cord-263357-krvei97r 11 15 have have VBP cord-263357-krvei97r 11 16 been be VBN cord-263357-krvei97r 11 17 discovered discover VBN cord-263357-krvei97r 11 18 , , , cord-263357-krvei97r 11 19 primarily primarily RB cord-263357-krvei97r 11 20 by by IN cord-263357-krvei97r 11 21 using use VBG cord-263357-krvei97r 11 22 highly highly RB cord-263357-krvei97r 11 23 sensitive sensitive JJ cord-263357-krvei97r 11 24 nucleotide nucleotide JJ cord-263357-krvei97r 11 25 sequencing sequencing NN cord-263357-krvei97r 11 26 and and CC cord-263357-krvei97r 11 27 new new JJ cord-263357-krvei97r 11 28 virus virus NN cord-263357-krvei97r 11 29 detection detection NN cord-263357-krvei97r 11 30 technologies technology NNS cord-263357-krvei97r 11 31 . . . cord-263357-krvei97r 12 1 These these DT cord-263357-krvei97r 12 2 human human JJ cord-263357-krvei97r 12 3 viruses virus NNS cord-263357-krvei97r 12 4 include include VBP cord-263357-krvei97r 12 5 human human JJ cord-263357-krvei97r 12 6 metapneumovirus metapneumovirus NN cord-263357-krvei97r 12 7 , , , cord-263357-krvei97r 12 8 rhinoviruses rhinovirus NNS cord-263357-krvei97r 12 9 in in IN cord-263357-krvei97r 12 10 clade clade NN cord-263357-krvei97r 12 11 C C NNP cord-263357-krvei97r 12 12 , , , cord-263357-krvei97r 12 13 bocavirus bocavirus NNP cord-263357-krvei97r 12 14 , , , cord-263357-krvei97r 12 15 polyomaviruses polyomaviruse VBZ cord-263357-krvei97r 12 16 WU WU NNP cord-263357-krvei97r 12 17 and and CC cord-263357-krvei97r 12 18 KI KI NNP cord-263357-krvei97r 12 19 2009 2009 CD cord-263357-krvei97r 12 20 pandemic pandemic NN cord-263357-krvei97r 12 21 H1N1 H1N1 NNP cord-263357-krvei97r 12 22 influenza influenza NN cord-263357-krvei97r 12 23 virus virus NN cord-263357-krvei97r 12 24 , , , cord-263357-krvei97r 12 25 and and CC cord-263357-krvei97r 12 26 3 3 CD cord-263357-krvei97r 12 27 new new JJ cord-263357-krvei97r 12 28 human human JJ cord-263357-krvei97r 12 29 coronaviruses coronaviruse NNS cord-263357-krvei97r 12 30 ( ( -LRB- cord-263357-krvei97r 12 31 HCoV HCoV NNP cord-263357-krvei97r 12 32 ) ) -RRB- cord-263357-krvei97r 12 33 . . . cord-263357-krvei97r 13 1 Until until IN cord-263357-krvei97r 13 2 2003 2003 CD cord-263357-krvei97r 13 3 , , , cord-263357-krvei97r 13 4 only only RB cord-263357-krvei97r 13 5 two two CD cord-263357-krvei97r 13 6 coronaviruses coronaviruse NNS cord-263357-krvei97r 13 7 , , , cord-263357-krvei97r 13 8 HCoV HCoV NNP cord-263357-krvei97r 13 9 - - HYPH cord-263357-krvei97r 13 10 OC43 OC43 NNP cord-263357-krvei97r 13 11 and and CC cord-263357-krvei97r 13 12 HCoV-229E HCoV-229E NNP cord-263357-krvei97r 13 13 , , , cord-263357-krvei97r 13 14 were be VBD cord-263357-krvei97r 13 15 known know VBN cord-263357-krvei97r 13 16 to to TO cord-263357-krvei97r 13 17 cause cause VB cord-263357-krvei97r 13 18 human human JJ cord-263357-krvei97r 13 19 disease disease NN cord-263357-krvei97r 13 20 , , , cord-263357-krvei97r 13 21 primarily primarily RB cord-263357-krvei97r 13 22 upper upper JJ cord-263357-krvei97r 13 23 respiratory respiratory JJ cord-263357-krvei97r 13 24 tract tract NN cord-263357-krvei97r 13 25 infections infection NNS cord-263357-krvei97r 13 26 . . . cord-263357-krvei97r 14 1 The the DT cord-263357-krvei97r 14 2 discovery discovery NN cord-263357-krvei97r 14 3 of of IN cord-263357-krvei97r 14 4 severe severe JJ cord-263357-krvei97r 14 5 acute acute JJ cord-263357-krvei97r 14 6 respiratory respiratory JJ cord-263357-krvei97r 14 7 syndrome syndrome NN cord-263357-krvei97r 14 8 - - HYPH cord-263357-krvei97r 14 9 CoV CoV NNP cord-263357-krvei97r 14 10 ( ( -LRB- cord-263357-krvei97r 14 11 SARS SARS NNP cord-263357-krvei97r 14 12 - - HYPH cord-263357-krvei97r 14 13 CoV CoV NNP cord-263357-krvei97r 14 14 ) ) -RRB- cord-263357-krvei97r 14 15 as as IN cord-263357-krvei97r 14 16 the the DT cord-263357-krvei97r 14 17 cause cause NN cord-263357-krvei97r 14 18 of of IN cord-263357-krvei97r 14 19 the the DT cord-263357-krvei97r 14 20 SARS SARS NNP cord-263357-krvei97r 14 21 pandemic pandemic NN cord-263357-krvei97r 14 22 of of IN cord-263357-krvei97r 14 23 2002 2002 CD cord-263357-krvei97r 14 24 to to IN cord-263357-krvei97r 14 25 2003 2003 CD cord-263357-krvei97r 14 26 demonstrated demonstrate VBD cord-263357-krvei97r 14 27 the the DT cord-263357-krvei97r 14 28 epidemic epidemic NN cord-263357-krvei97r 14 29 potential potential NN cord-263357-krvei97r 14 30 of of IN cord-263357-krvei97r 14 31 this this DT cord-263357-krvei97r 14 32 large large JJ cord-263357-krvei97r 14 33 family family NN cord-263357-krvei97r 14 34 of of IN cord-263357-krvei97r 14 35 RNA RNA NNP cord-263357-krvei97r 14 36 viruses virus NNS cord-263357-krvei97r 14 37 and and CC cord-263357-krvei97r 14 38 emphasized emphasize VBD cord-263357-krvei97r 14 39 their -PRON- PRP$ cord-263357-krvei97r 14 40 importance importance NN cord-263357-krvei97r 14 41 in in IN cord-263357-krvei97r 14 42 human human JJ cord-263357-krvei97r 14 43 respiratory respiratory JJ cord-263357-krvei97r 14 44 diseases disease NNS cord-263357-krvei97r 14 45 . . . cord-263357-krvei97r 15 1 After after IN cord-263357-krvei97r 15 2 the the DT cord-263357-krvei97r 15 3 SARS SARS NNP cord-263357-krvei97r 15 4 pandemic pandemic NN cord-263357-krvei97r 15 5 , , , cord-263357-krvei97r 15 6 two two CD cord-263357-krvei97r 15 7 additional additional JJ cord-263357-krvei97r 15 8 human human JJ cord-263357-krvei97r 15 9 coronaviruses coronaviruse NNS cord-263357-krvei97r 15 10 , , , cord-263357-krvei97r 15 11 NL63 NL63 NNP cord-263357-krvei97r 15 12 and and CC cord-263357-krvei97r 15 13 HKU1 HKU1 NNP cord-263357-krvei97r 15 14 , , , cord-263357-krvei97r 15 15 were be VBD cord-263357-krvei97r 15 16 identified identify VBN cord-263357-krvei97r 15 17 and and CC cord-263357-krvei97r 15 18 found find VBN cord-263357-krvei97r 15 19 to to TO cord-263357-krvei97r 15 20 cause cause VB cord-263357-krvei97r 15 21 both both CC cord-263357-krvei97r 15 22 upper upper JJ cord-263357-krvei97r 15 23 and and CC cord-263357-krvei97r 15 24 lower low JJR cord-263357-krvei97r 15 25 respiratory respiratory JJ cord-263357-krvei97r 15 26 tract tract NN cord-263357-krvei97r 15 27 disease disease NN cord-263357-krvei97r 15 28 . . . cord-263357-krvei97r 16 1 Although although IN cord-263357-krvei97r 16 2 these these DT cord-263357-krvei97r 16 3 coronaviruses coronaviruse NNS cord-263357-krvei97r 16 4 were be VBD cord-263357-krvei97r 16 5 only only RB cord-263357-krvei97r 16 6 recently recently RB cord-263357-krvei97r 16 7 discovered discover VBN cord-263357-krvei97r 16 8 , , , cord-263357-krvei97r 16 9 they -PRON- PRP cord-263357-krvei97r 16 10 have have VBP cord-263357-krvei97r 16 11 probably probably RB cord-263357-krvei97r 16 12 been be VBN cord-263357-krvei97r 16 13 circulating circulate VBG cord-263357-krvei97r 16 14 in in IN cord-263357-krvei97r 16 15 the the DT cord-263357-krvei97r 16 16 human human JJ cord-263357-krvei97r 16 17 population population NN cord-263357-krvei97r 16 18 worldwide worldwide RB cord-263357-krvei97r 16 19 for for IN cord-263357-krvei97r 16 20 a a DT cord-263357-krvei97r 16 21 long long JJ cord-263357-krvei97r 16 22 time time NN cord-263357-krvei97r 16 23 . . . cord-263357-krvei97r 17 1 HCoV HCoV NNP cord-263357-krvei97r 17 2 - - : cord-263357-krvei97r 17 3 OC43 OC43 NNP cord-263357-krvei97r 17 4 apparently apparently RB cord-263357-krvei97r 17 5 jumped jump VBD cord-263357-krvei97r 17 6 from from IN cord-263357-krvei97r 17 7 a a DT cord-263357-krvei97r 17 8 bovine bovine JJ cord-263357-krvei97r 17 9 host host NN cord-263357-krvei97r 17 10 into into IN cord-263357-krvei97r 17 11 humans human NNS cord-263357-krvei97r 17 12 more more JJR cord-263357-krvei97r 17 13 than than IN cord-263357-krvei97r 17 14 100 100 CD cord-263357-krvei97r 17 15 years year NNS cord-263357-krvei97r 17 16 ago ago RB cord-263357-krvei97r 17 17 and and CC cord-263357-krvei97r 17 18 has have VBZ cord-263357-krvei97r 17 19 become become VBN cord-263357-krvei97r 17 20 endemic endemic JJ cord-263357-krvei97r 17 21 worldwide worldwide RB cord-263357-krvei97r 17 22 . . . cord-263357-krvei97r 18 1 In in IN cord-263357-krvei97r 18 2 contrast contrast NN cord-263357-krvei97r 18 3 , , , cord-263357-krvei97r 18 4 the the DT cord-263357-krvei97r 18 5 SARS SARS NNP cord-263357-krvei97r 18 6 pandemic pandemic NN cord-263357-krvei97r 18 7 was be VBD cord-263357-krvei97r 18 8 caused cause VBN cord-263357-krvei97r 18 9 by by IN cord-263357-krvei97r 18 10 a a DT cord-263357-krvei97r 18 11 novel novel JJ cord-263357-krvei97r 18 12 human human JJ cord-263357-krvei97r 18 13 virus virus NN cord-263357-krvei97r 18 14 that that WDT cord-263357-krvei97r 18 15 had have VBD cord-263357-krvei97r 18 16 very very RB cord-263357-krvei97r 18 17 recently recently RB cord-263357-krvei97r 18 18 emerged emerge VBN cord-263357-krvei97r 18 19 into into IN cord-263357-krvei97r 18 20 the the DT cord-263357-krvei97r 18 21 human human JJ cord-263357-krvei97r 18 22 population population NN cord-263357-krvei97r 18 23 from from IN cord-263357-krvei97r 18 24 its -PRON- PRP$ cord-263357-krvei97r 18 25 zoonotic zoonotic JJ cord-263357-krvei97r 18 26 reservoirs reservoir NNS cord-263357-krvei97r 18 27 , , , cord-263357-krvei97r 18 28 Chinese chinese JJ cord-263357-krvei97r 18 29 horseshoe horseshoe NN cord-263357-krvei97r 18 30 bats bat NNS cord-263357-krvei97r 18 31 ( ( -LRB- cord-263357-krvei97r 18 32 suborder suborder NN cord-263357-krvei97r 18 33 Microchiroptera Microchiroptera NNP cord-263357-krvei97r 18 34 , , , cord-263357-krvei97r 18 35 family family NN cord-263357-krvei97r 18 36 Rhinolophidae Rhinolophidae NNP cord-263357-krvei97r 18 37 , , , cord-263357-krvei97r 18 38 genus genus JJ cord-263357-krvei97r 18 39 Rhinolophus Rhinolophus NNP cord-263357-krvei97r 18 40 ) ) -RRB- cord-263357-krvei97r 18 41 ( ( -LRB- cord-263357-krvei97r 18 42 1 1 CD cord-263357-krvei97r 18 43 , , , cord-263357-krvei97r 18 44 2 2 CD cord-263357-krvei97r 18 45 ) ) -RRB- cord-263357-krvei97r 18 46 . . . cord-263357-krvei97r 19 1 Indeed indeed RB cord-263357-krvei97r 19 2 , , , cord-263357-krvei97r 19 3 extensive extensive JJ cord-263357-krvei97r 19 4 phylogenetic phylogenetic JJ cord-263357-krvei97r 19 5 studies study NNS cord-263357-krvei97r 19 6 suggest suggest VBP cord-263357-krvei97r 19 7 that that IN cord-263357-krvei97r 19 8 all all DT cord-263357-krvei97r 19 9 alpha alpha NN cord-263357-krvei97r 19 10 - - HYPH cord-263357-krvei97r 19 11 and and CC cord-263357-krvei97r 19 12 beta beta NN cord-263357-krvei97r 19 13 coronaviruses coronaviruse NNS cord-263357-krvei97r 19 14 may may MD cord-263357-krvei97r 19 15 be be VB cord-263357-krvei97r 19 16 derived derive VBN cord-263357-krvei97r 19 17 from from IN cord-263357-krvei97r 19 18 bat bat NN cord-263357-krvei97r 19 19 coronaviruses coronaviruse NNS cord-263357-krvei97r 19 20 ( ( -LRB- cord-263357-krvei97r 19 21 3 3 CD cord-263357-krvei97r 19 22 ) ) -RRB- cord-263357-krvei97r 19 23 . . . cord-263357-krvei97r 20 1 In in IN cord-263357-krvei97r 20 2 June June NNP cord-263357-krvei97r 20 3 2012 2012 CD cord-263357-krvei97r 20 4 , , , cord-263357-krvei97r 20 5 a a DT cord-263357-krvei97r 20 6 novel novel JJ cord-263357-krvei97r 20 7 coronavirus coronavirus NN cord-263357-krvei97r 20 8 , , , cord-263357-krvei97r 20 9 tentatively tentatively RB cord-263357-krvei97r 20 10 named name VBN cord-263357-krvei97r 20 11 HCoV HCoV NNP cord-263357-krvei97r 20 12 - - HYPH cord-263357-krvei97r 20 13 EMC EMC NNP cord-263357-krvei97r 20 14 ( ( -LRB- cord-263357-krvei97r 20 15 for for IN cord-263357-krvei97r 20 16 Erasmus Erasmus NNP cord-263357-krvei97r 20 17 Medical Medical NNP cord-263357-krvei97r 20 18 Center Center NNP cord-263357-krvei97r 20 19 where where WRB cord-263357-krvei97r 20 20 the the DT cord-263357-krvei97r 20 21 initial initial JJ cord-263357-krvei97r 20 22 genome genome NN cord-263357-krvei97r 20 23 sequence sequence NN cord-263357-krvei97r 20 24 was be VBD cord-263357-krvei97r 20 25 done do VBN cord-263357-krvei97r 20 26 ) ) -RRB- cord-263357-krvei97r 20 27 , , , cord-263357-krvei97r 20 28 was be VBD cord-263357-krvei97r 20 29 isolated isolate VBN cord-263357-krvei97r 20 30 in in IN cord-263357-krvei97r 20 31 a a DT cord-263357-krvei97r 20 32 monkey monkey NN cord-263357-krvei97r 20 33 kidney kidney NN cord-263357-krvei97r 20 34 cell cell NN cord-263357-krvei97r 20 35 line line NN cord-263357-krvei97r 20 36 from from IN cord-263357-krvei97r 20 37 a a DT cord-263357-krvei97r 20 38 sputum sputum NN cord-263357-krvei97r 20 39 specimen specimen NN cord-263357-krvei97r 20 40 from from IN cord-263357-krvei97r 20 41 a a DT cord-263357-krvei97r 20 42 60-year 60-year JJ cord-263357-krvei97r 20 43 - - HYPH cord-263357-krvei97r 20 44 old old JJ cord-263357-krvei97r 20 45 man man NN cord-263357-krvei97r 20 46 from from IN cord-263357-krvei97r 20 47 the the DT cord-263357-krvei97r 20 48 Kingdom Kingdom NNP cord-263357-krvei97r 20 49 of of IN cord-263357-krvei97r 20 50 Saudi Saudi NNP cord-263357-krvei97r 20 51 Arabia Arabia NNP cord-263357-krvei97r 20 52 who who WP cord-263357-krvei97r 20 53 died die VBD cord-263357-krvei97r 20 54 of of IN cord-263357-krvei97r 20 55 acute acute JJ cord-263357-krvei97r 20 56 severe severe JJ cord-263357-krvei97r 20 57 pneumonia pneumonia NN cord-263357-krvei97r 20 58 and and CC cord-263357-krvei97r 20 59 renal renal JJ cord-263357-krvei97r 20 60 failure failure NN cord-263357-krvei97r 20 61 . . . cord-263357-krvei97r 21 1 Results result NNS cord-263357-krvei97r 21 2 of of IN cord-263357-krvei97r 21 3 standard standard JJ cord-263357-krvei97r 21 4 diagnostic diagnostic JJ cord-263357-krvei97r 21 5 tests test NNS cord-263357-krvei97r 21 6 of of IN cord-263357-krvei97r 21 7 his -PRON- PRP$ cord-263357-krvei97r 21 8 clinical clinical JJ cord-263357-krvei97r 21 9 samples sample NNS cord-263357-krvei97r 21 10 for for IN cord-263357-krvei97r 21 11 known know VBN cord-263357-krvei97r 21 12 respiratory respiratory JJ cord-263357-krvei97r 21 13 viruses virus NNS cord-263357-krvei97r 21 14 were be VBD cord-263357-krvei97r 21 15 all all DT cord-263357-krvei97r 21 16 negative negative JJ cord-263357-krvei97r 21 17 , , , cord-263357-krvei97r 21 18 which which WDT cord-263357-krvei97r 21 19 prompted prompt VBD cord-263357-krvei97r 21 20 testing testing NN cord-263357-krvei97r 21 21 of of IN cord-263357-krvei97r 21 22 infected infected JJ cord-263357-krvei97r 21 23 cell cell NN cord-263357-krvei97r 21 24 culture culture NN cord-263357-krvei97r 21 25 supernatants supernatant NNS cord-263357-krvei97r 21 26 using use VBG cord-263357-krvei97r 21 27 a a DT cord-263357-krvei97r 21 28 pan pan NN cord-263357-krvei97r 21 29 - - JJ cord-263357-krvei97r 21 30 coronavirus coronavirus NN cord-263357-krvei97r 21 31 reverse reverse VB cord-263357-krvei97r 21 32 transcription transcription NN cord-263357-krvei97r 21 33 - - HYPH cord-263357-krvei97r 21 34 PCR PCR NNP cord-263357-krvei97r 21 35 ( ( -LRB- cord-263357-krvei97r 21 36 RT RT NNP cord-263357-krvei97r 21 37 - - HYPH cord-263357-krvei97r 21 38 PCR PCR NNP cord-263357-krvei97r 21 39 ) ) -RRB- cord-263357-krvei97r 21 40 assay assay NN cord-263357-krvei97r 21 41 to to TO cord-263357-krvei97r 21 42 amplify amplify VB cord-263357-krvei97r 21 43 a a DT cord-263357-krvei97r 21 44 short short JJ cord-263357-krvei97r 21 45 , , , cord-263357-krvei97r 21 46 highly highly RB cord-263357-krvei97r 21 47 conserved conserve VBN cord-263357-krvei97r 21 48 region region NN cord-263357-krvei97r 21 49 of of IN cord-263357-krvei97r 21 50 the the DT cord-263357-krvei97r 21 51 RNA RNA NNP cord-263357-krvei97r 21 52 - - HYPH cord-263357-krvei97r 21 53 dependent dependent JJ cord-263357-krvei97r 21 54 RNA RNA NNP cord-263357-krvei97r 21 55 polymerase polymerase NN cord-263357-krvei97r 21 56 gene gene NN cord-263357-krvei97r 21 57 . . . cord-263357-krvei97r 22 1 Sequencing sequence VBG cord-263357-krvei97r 22 2 the the DT cord-263357-krvei97r 22 3 amplicon amplicon NN cord-263357-krvei97r 22 4 from from IN cord-263357-krvei97r 22 5 the the DT cord-263357-krvei97r 22 6 patient patient NN cord-263357-krvei97r 22 7 's 's POS cord-263357-krvei97r 22 8 specimen specimen NN cord-263357-krvei97r 22 9 revealed reveal VBD cord-263357-krvei97r 22 10 the the DT cord-263357-krvei97r 22 11 novel novel JJ cord-263357-krvei97r 22 12 human human JJ cord-263357-krvei97r 22 13 coronavirus coronavirus NN cord-263357-krvei97r 22 14 ( ( -LRB- cord-263357-krvei97r 22 15 4 4 CD cord-263357-krvei97r 22 16 ) ) -RRB- cord-263357-krvei97r 22 17 . . . cord-263357-krvei97r 23 1 The the DT cord-263357-krvei97r 23 2 discovery discovery NN cord-263357-krvei97r 23 3 of of IN cord-263357-krvei97r 23 4 a a DT cord-263357-krvei97r 23 5 new new JJ cord-263357-krvei97r 23 6 coronavirus coronavirus NN cord-263357-krvei97r 23 7 in in IN cord-263357-krvei97r 23 8 a a DT cord-263357-krvei97r 23 9 patient patient NN cord-263357-krvei97r 23 10 who who WP cord-263357-krvei97r 23 11 died die VBD cord-263357-krvei97r 23 12 of of IN cord-263357-krvei97r 23 13 severe severe JJ cord-263357-krvei97r 23 14 respiratory respiratory JJ cord-263357-krvei97r 23 15 disease disease NN cord-263357-krvei97r 23 16 was be VBD cord-263357-krvei97r 23 17 promptly promptly RB cord-263357-krvei97r 23 18 reported report VBN cord-263357-krvei97r 23 19 to to IN cord-263357-krvei97r 23 20 the the DT cord-263357-krvei97r 23 21 World World NNP cord-263357-krvei97r 23 22 Health Health NNP cord-263357-krvei97r 23 23 Organization Organization NNP cord-263357-krvei97r 23 24 and and CC cord-263357-krvei97r 23 25 posted post VBN cord-263357-krvei97r 23 26 on on IN cord-263357-krvei97r 23 27 ProMed ProMed NNP cord-263357-krvei97r 23 28 to to TO cord-263357-krvei97r 23 29 alert alert VB cord-263357-krvei97r 23 30 physicians physician NNS cord-263357-krvei97r 23 31 and and CC cord-263357-krvei97r 23 32 diagnostic diagnostic JJ cord-263357-krvei97r 23 33 laboratories laboratory NNS cord-263357-krvei97r 23 34 to to TO cord-263357-krvei97r 23 35 look look VB cord-263357-krvei97r 23 36 for for IN cord-263357-krvei97r 23 37 additional additional JJ cord-263357-krvei97r 23 38 cases case NNS cord-263357-krvei97r 23 39 . . . cord-263357-krvei97r 24 1 Eight eight CD cord-263357-krvei97r 24 2 additional additional JJ cord-263357-krvei97r 24 3 patients patient NNS cord-263357-krvei97r 24 4 from from IN cord-263357-krvei97r 24 5 the the DT cord-263357-krvei97r 24 6 Middle Middle NNP cord-263357-krvei97r 24 7 East East NNP cord-263357-krvei97r 24 8 with with IN cord-263357-krvei97r 24 9 HCoV HCoV NNP cord-263357-krvei97r 24 10 - - HYPH cord-263357-krvei97r 24 11 EMC EMC NNP cord-263357-krvei97r 24 12 infection infection NN cord-263357-krvei97r 24 13 and and CC cord-263357-krvei97r 24 14 severe severe JJ cord-263357-krvei97r 24 15 respiratory respiratory JJ cord-263357-krvei97r 24 16 disease disease NN cord-263357-krvei97r 24 17 have have VBP cord-263357-krvei97r 24 18 been be VBN cord-263357-krvei97r 24 19 identified identify VBN cord-263357-krvei97r 24 20 , , , cord-263357-krvei97r 24 21 bringing bring VBG cord-263357-krvei97r 24 22 the the DT cord-263357-krvei97r 24 23 total total NN cord-263357-krvei97r 24 24 of of IN cord-263357-krvei97r 24 25 laboratory laboratory NN cord-263357-krvei97r 24 26 - - HYPH cord-263357-krvei97r 24 27 confirmed confirm VBN cord-263357-krvei97r 24 28 cases case NNS cord-263357-krvei97r 24 29 up up IN cord-263357-krvei97r 24 30 to to TO cord-263357-krvei97r 24 31 9 9 CD cord-263357-krvei97r 24 32 , , , cord-263357-krvei97r 24 33 with with IN cord-263357-krvei97r 24 34 5 5 CD cord-263357-krvei97r 24 35 deaths death NNS cord-263357-krvei97r 24 36 ( ( -LRB- cord-263357-krvei97r 24 37 5 5 CD cord-263357-krvei97r 24 38 ) ) -RRB- cord-263357-krvei97r 24 39 . . . cord-263357-krvei97r 25 1 In in IN cord-263357-krvei97r 25 2 a a DT cord-263357-krvei97r 25 3 recent recent JJ cord-263357-krvei97r 25 4 article article NN cord-263357-krvei97r 25 5 , , , cord-263357-krvei97r 25 6 van van NNP cord-263357-krvei97r 25 7 Boheemen Boheemen NNP cord-263357-krvei97r 25 8 et et FW cord-263357-krvei97r 25 9 al al NNP cord-263357-krvei97r 25 10 . . NNP cord-263357-krvei97r 25 11 described describe VBD cord-263357-krvei97r 25 12 the the DT cord-263357-krvei97r 25 13 characterization characterization NN cord-263357-krvei97r 25 14 of of IN cord-263357-krvei97r 25 15 the the DT cord-263357-krvei97r 25 16 HCoV HCoV NNP cord-263357-krvei97r 25 17 - - HYPH cord-263357-krvei97r 25 18 EMC EMC NNP cord-263357-krvei97r 25 19 genome genome NN cord-263357-krvei97r 25 20 using use VBG cord-263357-krvei97r 25 21 unbiased unbiased JJ cord-263357-krvei97r 25 22 high high JJ cord-263357-krvei97r 25 23 - - HYPH cord-263357-krvei97r 25 24 throughput throughput NN cord-263357-krvei97r 25 25 next next JJ cord-263357-krvei97r 25 26 - - HYPH cord-263357-krvei97r 25 27 generation generation NN cord-263357-krvei97r 25 28 sequencing sequencing NN cord-263357-krvei97r 25 29 and and CC cord-263357-krvei97r 25 30 state state NN cord-263357-krvei97r 25 31 - - HYPH cord-263357-krvei97r 25 32 of of IN cord-263357-krvei97r 25 33 - - HYPH cord-263357-krvei97r 25 34 the the DT cord-263357-krvei97r 25 35 - - HYPH cord-263357-krvei97r 25 36 art art NN cord-263357-krvei97r 25 37 bioinformatics bioinformatic NNS cord-263357-krvei97r 25 38 to to IN cord-263357-krvei97r 25 39 mine -PRON- PRP cord-263357-krvei97r 25 40 a a DT cord-263357-krvei97r 25 41 wealth wealth NN cord-263357-krvei97r 25 42 of of IN cord-263357-krvei97r 25 43 information information NN cord-263357-krvei97r 25 44 about about IN cord-263357-krvei97r 25 45 this this DT cord-263357-krvei97r 25 46 new new JJ cord-263357-krvei97r 25 47 human human JJ cord-263357-krvei97r 25 48 virus virus NN cord-263357-krvei97r 25 49 ( ( -LRB- cord-263357-krvei97r 25 50 6 6 CD cord-263357-krvei97r 25 51 ) ) -RRB- cord-263357-krvei97r 25 52 . . . cord-263357-krvei97r 26 1 What what WP cord-263357-krvei97r 26 2 can can MD cord-263357-krvei97r 26 3 analysis analysis NN cord-263357-krvei97r 26 4 of of IN cord-263357-krvei97r 26 5 its -PRON- PRP$ cord-263357-krvei97r 26 6 RNA RNA NNP cord-263357-krvei97r 26 7 genome genome NN cord-263357-krvei97r 26 8 tell tell VBP cord-263357-krvei97r 26 9 us -PRON- PRP cord-263357-krvei97r 26 10 about about IN cord-263357-krvei97r 26 11 this this DT cord-263357-krvei97r 26 12 new new JJ cord-263357-krvei97r 26 13 human human JJ cord-263357-krvei97r 26 14 coronavirus coronavirus NN cord-263357-krvei97r 26 15 ? ? . cord-263357-krvei97r 27 1 Analysis analysis NN cord-263357-krvei97r 27 2 of of IN cord-263357-krvei97r 27 3 the the DT cord-263357-krvei97r 27 4 HCoV HCoV NNP cord-263357-krvei97r 27 5 - - HYPH cord-263357-krvei97r 27 6 EMC EMC NNP cord-263357-krvei97r 27 7 genome genome NN cord-263357-krvei97r 27 8 was be VBD cord-263357-krvei97r 27 9 able able JJ cord-263357-krvei97r 27 10 to to TO cord-263357-krvei97r 27 11 distinguish distinguish VB cord-263357-krvei97r 27 12 whether whether IN cord-263357-krvei97r 27 13 HCoV HCoV NNP cord-263357-krvei97r 27 14 - - HYPH cord-263357-krvei97r 27 15 EMC EMC NNP cord-263357-krvei97r 27 16 was be VBD cord-263357-krvei97r 27 17 a a DT cord-263357-krvei97r 27 18 known know VBN cord-263357-krvei97r 27 19 human human JJ cord-263357-krvei97r 27 20 coronavirus coronavirus NN cord-263357-krvei97r 27 21 with with IN cord-263357-krvei97r 27 22 mutations mutation NNS cord-263357-krvei97r 27 23 that that WDT cord-263357-krvei97r 27 24 increased increase VBD cord-263357-krvei97r 27 25 its -PRON- PRP$ cord-263357-krvei97r 27 26 virulence virulence NN cord-263357-krvei97r 27 27 or or CC cord-263357-krvei97r 27 28 a a DT cord-263357-krvei97r 27 29 product product NN cord-263357-krvei97r 27 30 of of IN cord-263357-krvei97r 27 31 recombination recombination NN cord-263357-krvei97r 27 32 between between IN cord-263357-krvei97r 27 33 two two CD cord-263357-krvei97r 27 34 or or CC cord-263357-krvei97r 27 35 more more RBR cord-263357-krvei97r 27 36 known know VBN cord-263357-krvei97r 27 37 coronavirus coronavirus NN cord-263357-krvei97r 27 38 species specie NNS cord-263357-krvei97r 27 39 or or CC cord-263357-krvei97r 27 40 , , , cord-263357-krvei97r 27 41 like like IN cord-263357-krvei97r 27 42 SARS SARS NNP cord-263357-krvei97r 27 43 - - HYPH cord-263357-krvei97r 27 44 CoV CoV NNP cord-263357-krvei97r 27 45 , , , cord-263357-krvei97r 27 46 a a DT cord-263357-krvei97r 27 47 spillover spillover NN cord-263357-krvei97r 27 48 of of IN cord-263357-krvei97r 27 49 a a DT cord-263357-krvei97r 27 50 zoonotic zoonotic JJ cord-263357-krvei97r 27 51 coronavirus coronavirus NN cord-263357-krvei97r 27 52 that that WDT cord-263357-krvei97r 27 53 was be VBD cord-263357-krvei97r 27 54 transmitted transmit VBN cord-263357-krvei97r 27 55 , , , cord-263357-krvei97r 27 56 either either CC cord-263357-krvei97r 27 57 directly directly RB cord-263357-krvei97r 27 58 or or CC cord-263357-krvei97r 27 59 indirectly indirectly RB cord-263357-krvei97r 27 60 , , , cord-263357-krvei97r 27 61 to to IN cord-263357-krvei97r 27 62 humans human NNS cord-263357-krvei97r 27 63 from from IN cord-263357-krvei97r 27 64 an an DT cord-263357-krvei97r 27 65 animal animal NN cord-263357-krvei97r 27 66 reservoir reservoir NN cord-263357-krvei97r 27 67 . . . cord-263357-krvei97r 28 1 The the DT cord-263357-krvei97r 28 2 genomic genomic JJ cord-263357-krvei97r 28 3 analysis analysis NN cord-263357-krvei97r 28 4 showed show VBD cord-263357-krvei97r 28 5 that that IN cord-263357-krvei97r 28 6 HCoV HCoV NNP cord-263357-krvei97r 28 7 - - HYPH cord-263357-krvei97r 28 8 EMC EMC NNP cord-263357-krvei97r 28 9 is be VBZ cord-263357-krvei97r 28 10 a a DT cord-263357-krvei97r 28 11 new new JJ cord-263357-krvei97r 28 12 coronavirus coronavirus NN cord-263357-krvei97r 28 13 that that WDT cord-263357-krvei97r 28 14 had have VBD cord-263357-krvei97r 28 15 never never RB cord-263357-krvei97r 28 16 before before RB cord-263357-krvei97r 28 17 been be VBN cord-263357-krvei97r 28 18 detected detect VBN cord-263357-krvei97r 28 19 in in IN cord-263357-krvei97r 28 20 any any DT cord-263357-krvei97r 28 21 other other JJ cord-263357-krvei97r 28 22 species specie NNS cord-263357-krvei97r 28 23 . . . cord-263357-krvei97r 29 1 What what WP cord-263357-krvei97r 29 2 is be VBZ cord-263357-krvei97r 29 3 the the DT cord-263357-krvei97r 29 4 relationship relationship NN cord-263357-krvei97r 29 5 between between IN cord-263357-krvei97r 29 6 HCoV HCoV NNP cord-263357-krvei97r 29 7 - - HYPH cord-263357-krvei97r 29 8 EMC EMC NNP cord-263357-krvei97r 29 9 and and CC cord-263357-krvei97r 29 10 known know VBN cord-263357-krvei97r 29 11 coronaviruses coronaviruse NNS cord-263357-krvei97r 29 12 ? ? . cord-263357-krvei97r 30 1 According accord VBG cord-263357-krvei97r 30 2 to to IN cord-263357-krvei97r 30 3 the the DT cord-263357-krvei97r 30 4 current current JJ cord-263357-krvei97r 30 5 classification classification NN cord-263357-krvei97r 30 6 by by IN cord-263357-krvei97r 30 7 the the DT cord-263357-krvei97r 30 8 International International NNP cord-263357-krvei97r 30 9 Committee Committee NNP cord-263357-krvei97r 30 10 on on IN cord-263357-krvei97r 30 11 Taxonomy Taxonomy NNP cord-263357-krvei97r 30 12 of of IN cord-263357-krvei97r 30 13 Viruses Viruses NNPS cord-263357-krvei97r 30 14 , , , cord-263357-krvei97r 30 15 coronaviruses coronaviruse NNS cord-263357-krvei97r 30 16 are be VBP cord-263357-krvei97r 30 17 in in IN cord-263357-krvei97r 30 18 the the DT cord-263357-krvei97r 30 19 order order NN cord-263357-krvei97r 30 20 Nidovirales Nidovirales NNP cord-263357-krvei97r 30 21 , , , cord-263357-krvei97r 30 22 family family NN cord-263357-krvei97r 30 23 Coronaviridae Coronaviridae NNP cord-263357-krvei97r 30 24 , , , cord-263357-krvei97r 30 25 and and CC cord-263357-krvei97r 30 26 subfamily subfamily RB cord-263357-krvei97r 30 27 Coronavirinae Coronavirinae NNP cord-263357-krvei97r 30 28 . . . cord-263357-krvei97r 31 1 There there EX cord-263357-krvei97r 31 2 are be VBP cord-263357-krvei97r 31 3 at at IN cord-263357-krvei97r 31 4 least least JJS cord-263357-krvei97r 31 5 4 4 CD cord-263357-krvei97r 31 6 genera genus NNS cord-263357-krvei97r 31 7 , , , cord-263357-krvei97r 31 8 alpha- alpha- NNP cord-263357-krvei97r 31 9 , , , cord-263357-krvei97r 31 10 beta- beta- NN cord-263357-krvei97r 31 11 , , , cord-263357-krvei97r 31 12 gamma- gamma- JJ cord-263357-krvei97r 31 13 , , , cord-263357-krvei97r 31 14 and and CC cord-263357-krvei97r 31 15 deltacoronaviruses deltacoronaviruse NNS cord-263357-krvei97r 31 16 , , , cord-263357-krvei97r 31 17 and and CC cord-263357-krvei97r 31 18 the the DT cord-263357-krvei97r 31 19 many many JJ cord-263357-krvei97r 31 20 virus virus NN cord-263357-krvei97r 31 21 species specie NNS cord-263357-krvei97r 31 22 within within IN cord-263357-krvei97r 31 23 each each DT cord-263357-krvei97r 31 24 genus genus NN cord-263357-krvei97r 31 25 are be VBP cord-263357-krvei97r 31 26 grouped group VBN cord-263357-krvei97r 31 27 in in IN cord-263357-krvei97r 31 28 multiple multiple JJ cord-263357-krvei97r 31 29 lineages lineage NNS cord-263357-krvei97r 31 30 called call VBN cord-263357-krvei97r 31 31 a a DT cord-263357-krvei97r 31 32 , , , cord-263357-krvei97r 31 33 b b NN cord-263357-krvei97r 31 34 , , , cord-263357-krvei97r 31 35 c c NNP cord-263357-krvei97r 31 36 , , , cord-263357-krvei97r 31 37 etc etc FW cord-263357-krvei97r 31 38 . . . cord-263357-krvei97r 32 1 The the DT cord-263357-krvei97r 32 2 genome genome NN cord-263357-krvei97r 32 3 sequence sequence NN cord-263357-krvei97r 32 4 revealed reveal VBD cord-263357-krvei97r 32 5 that that IN cord-263357-krvei97r 32 6 HCoV HCoV NNP cord-263357-krvei97r 32 7 - - HYPH cord-263357-krvei97r 32 8 EMC EMC NNP cord-263357-krvei97r 32 9 is be VBZ cord-263357-krvei97r 32 10 a a DT cord-263357-krvei97r 32 11 betacoronavirus betacoronavirus NN cord-263357-krvei97r 32 12 in in IN cord-263357-krvei97r 32 13 lineage lineage NN cord-263357-krvei97r 32 14 c c NN cord-263357-krvei97r 32 15 , , , cord-263357-krvei97r 32 16 significantly significantly RB cord-263357-krvei97r 32 17 different different JJ cord-263357-krvei97r 32 18 from from IN cord-263357-krvei97r 32 19 SARS SARS NNP cord-263357-krvei97r 32 20 - - HYPH cord-263357-krvei97r 32 21 CoV CoV NNP cord-263357-krvei97r 32 22 , , , cord-263357-krvei97r 32 23 a a DT cord-263357-krvei97r 32 24 betacoronavirus betacoronavirus NN cord-263357-krvei97r 32 25 in in IN cord-263357-krvei97r 32 26 lineage lineage NN cord-263357-krvei97r 32 27 b b NN cord-263357-krvei97r 32 28 , , , cord-263357-krvei97r 32 29 and and CC cord-263357-krvei97r 32 30 human human JJ cord-263357-krvei97r 32 31 betacoronaviruses betacoronaviruse NNS cord-263357-krvei97r 32 32 OC43 OC43 NNP cord-263357-krvei97r 32 33 and and CC cord-263357-krvei97r 32 34 HKU1 HKU1 NNP cord-263357-krvei97r 32 35 , , , cord-263357-krvei97r 32 36 which which WDT cord-263357-krvei97r 32 37 are be VBP cord-263357-krvei97r 32 38 placed place VBN cord-263357-krvei97r 32 39 in in IN cord-263357-krvei97r 32 40 lineage lineage NN cord-263357-krvei97r 32 41 a. a. NN cord-263357-krvei97r 33 1 The the DT cord-263357-krvei97r 33 2 closest close JJS cord-263357-krvei97r 33 3 known know VBN cord-263357-krvei97r 33 4 relatives relative NNS cord-263357-krvei97r 33 5 of of IN cord-263357-krvei97r 33 6 HCoV HCoV NNP cord-263357-krvei97r 33 7 - - HYPH cord-263357-krvei97r 33 8 EMC EMC NNP cord-263357-krvei97r 33 9 in in IN cord-263357-krvei97r 33 10 lineage lineage NN cord-263357-krvei97r 33 11 c c NN cord-263357-krvei97r 33 12 are be VBP cord-263357-krvei97r 33 13 two two CD cord-263357-krvei97r 33 14 betacoronaviruses betacoronaviruse NNS cord-263357-krvei97r 33 15 of of IN cord-263357-krvei97r 33 16 Asian asian JJ cord-263357-krvei97r 33 17 bats bat NNS cord-263357-krvei97r 33 18 , , , cord-263357-krvei97r 33 19 but but CC cord-263357-krvei97r 33 20 because because IN cord-263357-krvei97r 33 21 HCoV HCoV NNP cord-263357-krvei97r 33 22 - - HYPH cord-263357-krvei97r 33 23 EMC EMC NNP cord-263357-krvei97r 33 24 and and CC cord-263357-krvei97r 33 25 the the DT cord-263357-krvei97r 33 26 bat bat NN cord-263357-krvei97r 33 27 viruses virus NNS cord-263357-krvei97r 33 28 have have VBP cord-263357-krvei97r 33 29 only only RB cord-263357-krvei97r 33 30 75 75 CD cord-263357-krvei97r 33 31 % % NN cord-263357-krvei97r 33 32 to to TO cord-263357-krvei97r 33 33 77 77 CD cord-263357-krvei97r 33 34 % % NN cord-263357-krvei97r 33 35 amino amino NN cord-263357-krvei97r 33 36 acid acid NN cord-263357-krvei97r 33 37 identity identity NN cord-263357-krvei97r 33 38 in in IN cord-263357-krvei97r 33 39 the the DT cord-263357-krvei97r 33 40 7 7 CD cord-263357-krvei97r 33 41 key key JJ cord-263357-krvei97r 33 42 conserved conserve VBN cord-263357-krvei97r 33 43 replicase replicase NN cord-263357-krvei97r 33 44 domains domain NNS cord-263357-krvei97r 33 45 used use VBN cord-263357-krvei97r 33 46 for for IN cord-263357-krvei97r 33 47 phylogenetic phylogenetic JJ cord-263357-krvei97r 33 48 analysis analysis NN cord-263357-krvei97r 33 49 , , , cord-263357-krvei97r 33 50 HCoV HCoV NNP cord-263357-krvei97r 33 51 - - HYPH cord-263357-krvei97r 33 52 EMC EMC NNP cord-263357-krvei97r 33 53 is be VBZ cord-263357-krvei97r 33 54 classified classify VBN cord-263357-krvei97r 33 55 as as IN cord-263357-krvei97r 33 56 a a DT cord-263357-krvei97r 33 57 novel novel JJ cord-263357-krvei97r 33 58 species species NN cord-263357-krvei97r 33 59 within within IN cord-263357-krvei97r 33 60 betacoronavirus betacoronavirus NNP cord-263357-krvei97r 33 61 lineage lineage NN cord-263357-krvei97r 33 62 c c NNP cord-263357-krvei97r 33 63 ( ( -LRB- cord-263357-krvei97r 33 64 6 6 CD cord-263357-krvei97r 33 65 ) ) -RRB- cord-263357-krvei97r 33 66 . . . cord-263357-krvei97r 34 1 The the DT cord-263357-krvei97r 34 2 genomic genomic JJ cord-263357-krvei97r 34 3 analysis analysis NN cord-263357-krvei97r 34 4 suggests suggest VBZ cord-263357-krvei97r 34 5 that that IN cord-263357-krvei97r 34 6 HCoV HCoV NNP cord-263357-krvei97r 34 7 - - HYPH cord-263357-krvei97r 34 8 EMC EMC NNP cord-263357-krvei97r 34 9 may may MD cord-263357-krvei97r 34 10 be be VB cord-263357-krvei97r 34 11 a a DT cord-263357-krvei97r 34 12 zoonotic zoonotic JJ cord-263357-krvei97r 34 13 virus virus NN cord-263357-krvei97r 34 14 that that WDT cord-263357-krvei97r 34 15 spilled spill VBD cord-263357-krvei97r 34 16 over over RP cord-263357-krvei97r 34 17 to to TO cord-263357-krvei97r 34 18 infect infect VB cord-263357-krvei97r 34 19 the the DT cord-263357-krvei97r 34 20 9 9 CD cord-263357-krvei97r 34 21 laboratory laboratory NN cord-263357-krvei97r 34 22 confirmed confirm VBD cord-263357-krvei97r 34 23 patients patient NNS cord-263357-krvei97r 34 24 , , , cord-263357-krvei97r 34 25 either either CC cord-263357-krvei97r 34 26 directly directly RB cord-263357-krvei97r 34 27 or or CC cord-263357-krvei97r 34 28 indirectly indirectly RB cord-263357-krvei97r 34 29 , , , cord-263357-krvei97r 34 30 from from IN cord-263357-krvei97r 34 31 an an DT cord-263357-krvei97r 34 32 unknown unknown JJ cord-263357-krvei97r 34 33 reservoir reservoir NN cord-263357-krvei97r 34 34 , , , cord-263357-krvei97r 34 35 possibly possibly RB cord-263357-krvei97r 34 36 a a DT cord-263357-krvei97r 34 37 bat bat NN cord-263357-krvei97r 34 38 . . . cord-263357-krvei97r 35 1 This this DT cord-263357-krvei97r 35 2 discovery discovery NN cord-263357-krvei97r 35 3 justifies justify VBZ cord-263357-krvei97r 35 4 the the DT cord-263357-krvei97r 35 5 recent recent JJ cord-263357-krvei97r 35 6 worldwide worldwide JJ cord-263357-krvei97r 35 7 surveillance surveillance NN cord-263357-krvei97r 35 8 of of IN cord-263357-krvei97r 35 9 wildlife wildlife NN cord-263357-krvei97r 35 10 for for IN cord-263357-krvei97r 35 11 coronavirus coronavirus NN cord-263357-krvei97r 35 12 infection infection NN cord-263357-krvei97r 35 13 and and CC cord-263357-krvei97r 35 14 the the DT cord-263357-krvei97r 35 15 extensive extensive JJ cord-263357-krvei97r 35 16 genome genome NN cord-263357-krvei97r 35 17 sequencing sequencing NN cord-263357-krvei97r 35 18 and and CC cord-263357-krvei97r 35 19 phylogenetic phylogenetic NN cord-263357-krvei97r 35 20 analysis analysis NN cord-263357-krvei97r 35 21 that that WDT cord-263357-krvei97r 35 22 have have VBP cord-263357-krvei97r 35 23 been be VBN cord-263357-krvei97r 35 24 done do VBN cord-263357-krvei97r 35 25 since since IN cord-263357-krvei97r 35 26 the the DT cord-263357-krvei97r 35 27 SARS SARS NNP cord-263357-krvei97r 35 28 pandemic pandemic NN cord-263357-krvei97r 35 29 to to TO cord-263357-krvei97r 35 30 identify identify VB cord-263357-krvei97r 35 31 potential potential JJ cord-263357-krvei97r 35 32 risk risk NN cord-263357-krvei97r 35 33 to to IN cord-263357-krvei97r 35 34 humans human NNS cord-263357-krvei97r 35 35 from from IN cord-263357-krvei97r 35 36 zoonotic zoonotic JJ cord-263357-krvei97r 35 37 coronavirus coronavirus NN cord-263357-krvei97r 35 38 infections infection NNS cord-263357-krvei97r 35 39 . . . cord-263357-krvei97r 36 1 What what WDT cord-263357-krvei97r 36 2 features feature NNS cord-263357-krvei97r 36 3 of of IN cord-263357-krvei97r 36 4 the the DT cord-263357-krvei97r 36 5 genome genome NN cord-263357-krvei97r 36 6 and and CC cord-263357-krvei97r 36 7 its -PRON- PRP$ cord-263357-krvei97r 36 8 translational translational JJ cord-263357-krvei97r 36 9 strategy strategy NN cord-263357-krvei97r 36 10 are be VBP cord-263357-krvei97r 36 11 similar similar JJ cord-263357-krvei97r 36 12 to to IN cord-263357-krvei97r 36 13 or or CC cord-263357-krvei97r 36 14 different different JJ cord-263357-krvei97r 36 15 from from IN cord-263357-krvei97r 36 16 those those DT cord-263357-krvei97r 36 17 of of IN cord-263357-krvei97r 36 18 other other JJ cord-263357-krvei97r 36 19 coronaviruses coronaviruse NNS cord-263357-krvei97r 36 20 ? ? . cord-263357-krvei97r 37 1 Like like IN cord-263357-krvei97r 37 2 all all DT cord-263357-krvei97r 37 3 coronaviruses coronaviruse NNS cord-263357-krvei97r 37 4 , , , cord-263357-krvei97r 37 5 HCoV HCoV NNP cord-263357-krvei97r 37 6 - - HYPH cord-263357-krvei97r 37 7 EMC EMC NNP cord-263357-krvei97r 37 8 has have VBZ cord-263357-krvei97r 37 9 a a DT cord-263357-krvei97r 37 10 single single RB cord-263357-krvei97r 37 11 - - HYPH cord-263357-krvei97r 37 12 stranded stranded JJ cord-263357-krvei97r 37 13 , , , cord-263357-krvei97r 37 14 plus plus NN cord-263357-krvei97r 37 15 - - HYPH cord-263357-krvei97r 37 16 sense sense NN cord-263357-krvei97r 37 17 , , , cord-263357-krvei97r 37 18 polyadenylated polyadenylate VBN cord-263357-krvei97r 37 19 RNA RNA NNP cord-263357-krvei97r 37 20 genome genome NN cord-263357-krvei97r 37 21 about about RB cord-263357-krvei97r 37 22 30 30 CD cord-263357-krvei97r 37 23 kb kb NNS cord-263357-krvei97r 37 24 in in IN cord-263357-krvei97r 37 25 length length NN cord-263357-krvei97r 37 26 . . . cord-263357-krvei97r 38 1 As as IN cord-263357-krvei97r 38 2 expected expect VBN cord-263357-krvei97r 38 3 , , , cord-263357-krvei97r 38 4 the the DT cord-263357-krvei97r 38 5 20-kb 20-kb CD cord-263357-krvei97r 38 6 sequence sequence NN cord-263357-krvei97r 38 7 at at IN cord-263357-krvei97r 38 8 the the DT cord-263357-krvei97r 38 9 5= 5= CD cord-263357-krvei97r 38 10 end end NN cord-263357-krvei97r 38 11 of of IN cord-263357-krvei97r 38 12 the the DT cord-263357-krvei97r 38 13 genome genome NN cord-263357-krvei97r 38 14 is be VBZ cord-263357-krvei97r 38 15 translated translate VBN cord-263357-krvei97r 38 16 to to TO cord-263357-krvei97r 38 17 yield yield VB cord-263357-krvei97r 38 18 a a DT cord-263357-krvei97r 38 19 huge huge JJ cord-263357-krvei97r 38 20 polyprotein polyprotein NN cord-263357-krvei97r 38 21 that that WDT cord-263357-krvei97r 38 22 is be VBZ cord-263357-krvei97r 38 23 cotranslationally cotranslationally RB cord-263357-krvei97r 38 24 cleaved cleave VBN cord-263357-krvei97r 38 25 in in IN cord-263357-krvei97r 38 26 cis cis NNP cord-263357-krvei97r 38 27 by by IN cord-263357-krvei97r 38 28 two two CD cord-263357-krvei97r 38 29 viral viral JJ cord-263357-krvei97r 38 30 proteases protease NNS cord-263357-krvei97r 38 31 into into IN cord-263357-krvei97r 38 32 16 16 CD cord-263357-krvei97r 38 33 functional functional JJ cord-263357-krvei97r 38 34 nonstructural nonstructural JJ cord-263357-krvei97r 38 35 proteins protein NNS cord-263357-krvei97r 38 36 that that WDT cord-263357-krvei97r 38 37 cooperatively cooperatively RB cord-263357-krvei97r 38 38 form form VBP cord-263357-krvei97r 38 39 the the DT cord-263357-krvei97r 38 40 complex complex JJ cord-263357-krvei97r 38 41 machinery machinery NN cord-263357-krvei97r 38 42 for for IN cord-263357-krvei97r 38 43 viral viral JJ cord-263357-krvei97r 38 44 RNA RNA NNP cord-263357-krvei97r 38 45 synthesis synthesis NN cord-263357-krvei97r 38 46 and and CC cord-263357-krvei97r 38 47 RNA RNA NNP cord-263357-krvei97r 38 48 recombination recombination NN cord-263357-krvei97r 38 49 . . . cord-263357-krvei97r 39 1 The the DT cord-263357-krvei97r 39 2 10-kb 10-kb CD cord-263357-krvei97r 39 3 sequence sequence NN cord-263357-krvei97r 39 4 in in IN cord-263357-krvei97r 39 5 the the DT cord-263357-krvei97r 39 6 3= 3= CD cord-263357-krvei97r 39 7 region region NN cord-263357-krvei97r 39 8 of of IN cord-263357-krvei97r 39 9 coronavirus coronavirus NN cord-263357-krvei97r 39 10 genomes genome NNS cord-263357-krvei97r 39 11 uses use VBZ cord-263357-krvei97r 39 12 a a DT cord-263357-krvei97r 39 13 different different JJ cord-263357-krvei97r 39 14 translational translational JJ cord-263357-krvei97r 39 15 strategy strategy NN cord-263357-krvei97r 39 16 . . . cord-263357-krvei97r 40 1 This this DT cord-263357-krvei97r 40 2 region region NN cord-263357-krvei97r 40 3 encodes encode VBZ cord-263357-krvei97r 40 4 4 4 CD cord-263357-krvei97r 40 5 structural structural JJ cord-263357-krvei97r 40 6 proteins protein NNS cord-263357-krvei97r 40 7 with with IN cord-263357-krvei97r 40 8 features feature NNS cord-263357-krvei97r 40 9 common common JJ cord-263357-krvei97r 40 10 to to IN cord-263357-krvei97r 40 11 all all DT cord-263357-krvei97r 40 12 CoVs CoVs NNP cord-263357-krvei97r 40 13 as as RB cord-263357-krvei97r 40 14 well well RB cord-263357-krvei97r 40 15 as as IN cord-263357-krvei97r 40 16 several several JJ cord-263357-krvei97r 40 17 so so RB cord-263357-krvei97r 40 18 - - HYPH cord-263357-krvei97r 40 19 called call VBN cord-263357-krvei97r 40 20 accessory accessory NN cord-263357-krvei97r 40 21 proteins protein NNS cord-263357-krvei97r 40 22 that that WDT cord-263357-krvei97r 40 23 are be VBP cord-263357-krvei97r 40 24 different different JJ cord-263357-krvei97r 40 25 for for IN cord-263357-krvei97r 40 26 each each DT cord-263357-krvei97r 40 27 coronavirus coronavirus NN cord-263357-krvei97r 40 28 and and CC cord-263357-krvei97r 40 29 whose whose WP$ cord-263357-krvei97r 40 30 origins origin NNS cord-263357-krvei97r 40 31 and and CC cord-263357-krvei97r 40 32 functions function NNS cord-263357-krvei97r 40 33 are be VBP cord-263357-krvei97r 40 34 unknown unknown JJ cord-263357-krvei97r 40 35 . . . cord-263357-krvei97r 41 1 A a DT cord-263357-krvei97r 41 2 nested nested JJ cord-263357-krvei97r 41 3 series series NN cord-263357-krvei97r 41 4 of of IN cord-263357-krvei97r 41 5 3= 3= CD cord-263357-krvei97r 41 6 coterminal coterminal NNP cord-263357-krvei97r 41 7 polyadenylated polyadenylate VBN cord-263357-krvei97r 41 8 subgenomic subgenomic NNP cord-263357-krvei97r 41 9 mRNAs mRNAs NNPS cord-263357-krvei97r 41 10 is be VBZ cord-263357-krvei97r 41 11 generated generate VBN cord-263357-krvei97r 41 12 in in IN cord-263357-krvei97r 41 13 the the DT cord-263357-krvei97r 41 14 cytoplasm cytoplasm NN cord-263357-krvei97r 41 15 , , , cord-263357-krvei97r 41 16 and and CC cord-263357-krvei97r 41 17 only only RB cord-263357-krvei97r 41 18 the the DT cord-263357-krvei97r 41 19 gene gene NN cord-263357-krvei97r 41 20 at at IN cord-263357-krvei97r 41 21 the the DT cord-263357-krvei97r 41 22 5= 5= CD cord-263357-krvei97r 41 23 end end NN cord-263357-krvei97r 41 24 of of IN cord-263357-krvei97r 41 25 each each DT cord-263357-krvei97r 41 26 of of IN cord-263357-krvei97r 41 27 these these DT cord-263357-krvei97r 41 28 mRNAs mRNAs NNPS cord-263357-krvei97r 41 29 is be VBZ cord-263357-krvei97r 41 30 translated translate VBN cord-263357-krvei97r 41 31 . . . cord-263357-krvei97r 42 1 The the DT cord-263357-krvei97r 42 2 genome genome NN cord-263357-krvei97r 42 3 reveals reveal VBZ cord-263357-krvei97r 42 4 conservation conservation NN cord-263357-krvei97r 42 5 in in IN cord-263357-krvei97r 42 6 HCoV HCoV NNP cord-263357-krvei97r 42 7 - - HYPH cord-263357-krvei97r 42 8 EMC EMC NNP cord-263357-krvei97r 42 9 of of IN cord-263357-krvei97r 42 10 several several JJ cord-263357-krvei97r 42 11 potential potential JJ cord-263357-krvei97r 42 12 targets target NNS cord-263357-krvei97r 42 13 for for IN cord-263357-krvei97r 42 14 drugs drug NNS cord-263357-krvei97r 42 15 and and CC cord-263357-krvei97r 42 16 vaccines vaccine NNS cord-263357-krvei97r 42 17 being be VBG cord-263357-krvei97r 42 18 developed develop VBN cord-263357-krvei97r 42 19 for for IN cord-263357-krvei97r 42 20 other other JJ cord-263357-krvei97r 42 21 CoVs CoVs NNP cord-263357-krvei97r 42 22 , , , cord-263357-krvei97r 42 23 including include VBG cord-263357-krvei97r 42 24 the the DT cord-263357-krvei97r 42 25 viral viral JJ cord-263357-krvei97r 42 26 spike spike NN cord-263357-krvei97r 42 27 glycoprotein glycoprotein NN cord-263357-krvei97r 42 28 ( ( -LRB- cord-263357-krvei97r 42 29 S S NNP cord-263357-krvei97r 42 30 ) ) -RRB- cord-263357-krvei97r 42 31 , , , cord-263357-krvei97r 42 32 virus virus NN cord-263357-krvei97r 42 33 - - HYPH cord-263357-krvei97r 42 34 encoded encode VBN cord-263357-krvei97r 42 35 proteases protease NNS cord-263357-krvei97r 42 36 , , , cord-263357-krvei97r 42 37 and and CC cord-263357-krvei97r 42 38 essential essential JJ cord-263357-krvei97r 42 39 enzymatic enzymatic JJ cord-263357-krvei97r 42 40 functions function NNS cord-263357-krvei97r 42 41 such such JJ cord-263357-krvei97r 42 42 as as IN cord-263357-krvei97r 42 43 the the DT cord-263357-krvei97r 42 44 RNA RNA NNP cord-263357-krvei97r 42 45 - - HYPH cord-263357-krvei97r 42 46 dependent dependent JJ cord-263357-krvei97r 42 47 RNA RNA NNP cord-263357-krvei97r 42 48 polymerase polymerase NN cord-263357-krvei97r 42 49 and and CC cord-263357-krvei97r 42 50 helicase helicase NN cord-263357-krvei97r 42 51 . . . cord-263357-krvei97r 43 1 How how WRB cord-263357-krvei97r 43 2 does do VBZ cord-263357-krvei97r 43 3 the the DT cord-263357-krvei97r 43 4 genomic genomic JJ cord-263357-krvei97r 43 5 analysis analysis NN cord-263357-krvei97r 43 6 of of IN cord-263357-krvei97r 43 7 HCoV HCoV NNP cord-263357-krvei97r 43 8 - - HYPH cord-263357-krvei97r 43 9 EMC EMC NNP cord-263357-krvei97r 43 10 expedite expedite VB cord-263357-krvei97r 43 11 further further JJ cord-263357-krvei97r 43 12 research research NN cord-263357-krvei97r 43 13 on on IN cord-263357-krvei97r 43 14 this this DT cord-263357-krvei97r 43 15 new new JJ cord-263357-krvei97r 43 16 human human JJ cord-263357-krvei97r 43 17 virus virus NN cord-263357-krvei97r 43 18 ? ? . cord-263357-krvei97r 44 1 As as RB cord-263357-krvei97r 44 2 soon soon RB cord-263357-krvei97r 44 3 as as IN cord-263357-krvei97r 44 4 partial partial JJ cord-263357-krvei97r 44 5 nucleotide nucleotide JJ cord-263357-krvei97r 44 6 sequences sequence NNS cord-263357-krvei97r 44 7 of of IN cord-263357-krvei97r 44 8 HCoV HCoV NNP cord-263357-krvei97r 44 9 - - HYPH cord-263357-krvei97r 44 10 EMC EMC NNP cord-263357-krvei97r 44 11 were be VBD cord-263357-krvei97r 44 12 available available JJ cord-263357-krvei97r 44 13 , , , cord-263357-krvei97r 44 14 sensitive sensitive JJ cord-263357-krvei97r 44 15 RT RT NNP cord-263357-krvei97r 44 16 - - HYPH cord-263357-krvei97r 44 17 PCR PCR NNP cord-263357-krvei97r 44 18 tests test NNS cord-263357-krvei97r 44 19 were be VBD cord-263357-krvei97r 44 20 developed develop VBN cord-263357-krvei97r 44 21 to to TO cord-263357-krvei97r 44 22 specifically specifically RB cord-263357-krvei97r 44 23 detect detect VB cord-263357-krvei97r 44 24 RNA RNA NNP cord-263357-krvei97r 44 25 of of IN cord-263357-krvei97r 44 26 this this DT cord-263357-krvei97r 44 27 virus virus NN cord-263357-krvei97r 44 28 in in IN cord-263357-krvei97r 44 29 tissues tissue NNS cord-263357-krvei97r 44 30 and and CC cord-263357-krvei97r 44 31 body body NN cord-263357-krvei97r 44 32 fluids fluid NNS cord-263357-krvei97r 44 33 of of IN cord-263357-krvei97r 44 34 humans human NNS cord-263357-krvei97r 44 35 and and CC cord-263357-krvei97r 44 36 animals animal NNS cord-263357-krvei97r 44 37 . . . cord-263357-krvei97r 45 1 These these DT cord-263357-krvei97r 45 2 tests test NNS cord-263357-krvei97r 45 3 are be VBP cord-263357-krvei97r 45 4 being be VBG cord-263357-krvei97r 45 5 used use VBN cord-263357-krvei97r 45 6 to to TO cord-263357-krvei97r 45 7 screen screen VB cord-263357-krvei97r 45 8 for for IN cord-263357-krvei97r 45 9 HCoV HCoV NNP cord-263357-krvei97r 45 10 - - HYPH cord-263357-krvei97r 45 11 EMC EMC NNP cord-263357-krvei97r 45 12 RNA RNA NNP cord-263357-krvei97r 45 13 in in IN cord-263357-krvei97r 45 14 patients patient NNS cord-263357-krvei97r 45 15 with with IN cord-263357-krvei97r 45 16 severe severe JJ cord-263357-krvei97r 45 17 respiratory respiratory JJ cord-263357-krvei97r 45 18 disease disease NN cord-263357-krvei97r 45 19 of of IN cord-263357-krvei97r 45 20 unknown unknown JJ cord-263357-krvei97r 45 21 etiology etiology NN cord-263357-krvei97r 45 22 and and CC cord-263357-krvei97r 45 23 in in IN cord-263357-krvei97r 45 24 wildlife wildlife NN cord-263357-krvei97r 45 25 surveillance surveillance NN cord-263357-krvei97r 45 26 . . . cord-263357-krvei97r 46 1 Based base VBN cord-263357-krvei97r 46 2 on on IN cord-263357-krvei97r 46 3 the the DT cord-263357-krvei97r 46 4 predicted predict VBN cord-263357-krvei97r 46 5 amino amino NN cord-263357-krvei97r 46 6 acid acid NN cord-263357-krvei97r 46 7 sequences sequence NNS cord-263357-krvei97r 46 8 of of IN cord-263357-krvei97r 46 9 the the DT cord-263357-krvei97r 46 10 HCoV HCoV NNP cord-263357-krvei97r 46 11 - - HYPH cord-263357-krvei97r 46 12 EMC EMC NNP cord-263357-krvei97r 46 13 proteins protein NNS cord-263357-krvei97r 46 14 , , , cord-263357-krvei97r 46 15 plasmids plasmid NNS cord-263357-krvei97r 46 16 can can MD cord-263357-krvei97r 46 17 be be VB cord-263357-krvei97r 46 18 engineered engineer VBN cord-263357-krvei97r 46 19 to to TO cord-263357-krvei97r 46 20 express express VB cord-263357-krvei97r 46 21 the the DT cord-263357-krvei97r 46 22 proteins protein NNS cord-263357-krvei97r 46 23 for for IN cord-263357-krvei97r 46 24 structural structural JJ cord-263357-krvei97r 46 25 , , , cord-263357-krvei97r 46 26 antigenic antigenic JJ cord-263357-krvei97r 46 27 , , , cord-263357-krvei97r 46 28 and and CC cord-263357-krvei97r 46 29 functional functional JJ cord-263357-krvei97r 46 30 studies study NNS cord-263357-krvei97r 46 31 . . . cord-263357-krvei97r 47 1 Recombinant recombinant JJ cord-263357-krvei97r 47 2 viral viral JJ cord-263357-krvei97r 47 3 proteins protein NNS cord-263357-krvei97r 47 4 are be VBP cord-263357-krvei97r 47 5 being be VBG cord-263357-krvei97r 47 6 used use VBN cord-263357-krvei97r 47 7 in in IN cord-263357-krvei97r 47 8 enzyme enzyme NN cord-263357-krvei97r 47 9 - - HYPH cord-263357-krvei97r 47 10 linked link VBN cord-263357-krvei97r 47 11 immunosorbent immunosorbent JJ cord-263357-krvei97r 47 12 assays assay NNS cord-263357-krvei97r 47 13 ( ( -LRB- cord-263357-krvei97r 47 14 ELISAs elisa NNS cord-263357-krvei97r 47 15 ) ) -RRB- cord-263357-krvei97r 47 16 to to TO cord-263357-krvei97r 47 17 detect detect VB cord-263357-krvei97r 47 18 HCoV HCoV NNP cord-263357-krvei97r 47 19 - - HYPH cord-263357-krvei97r 47 20 EMC EMC NNP cord-263357-krvei97r 47 21 - - HYPH cord-263357-krvei97r 47 22 specific specific JJ cord-263357-krvei97r 47 23 antibodies antibody NNS cord-263357-krvei97r 47 24 in in IN cord-263357-krvei97r 47 25 sera sera NNP cord-263357-krvei97r 47 26 . . . cord-263357-krvei97r 48 1 HCoV HCoV NNP cord-263357-krvei97r 48 2 - - HYPH cord-263357-krvei97r 48 3 EMC EMC NNP cord-263357-krvei97r 48 4 spike spike NN cord-263357-krvei97r 48 5 protein protein NN cord-263357-krvei97r 48 6 in in IN cord-263357-krvei97r 48 7 retrovirus retrovirus NN cord-263357-krvei97r 48 8 pseudotypes pseudotype NNS cord-263357-krvei97r 48 9 can can MD cord-263357-krvei97r 48 10 be be VB cord-263357-krvei97r 48 11 used use VBN cord-263357-krvei97r 48 12 to to TO cord-263357-krvei97r 48 13 identify identify VB cord-263357-krvei97r 48 14 the the DT cord-263357-krvei97r 48 15 virus virus NN cord-263357-krvei97r 48 16 receptor receptor NN cord-263357-krvei97r 48 17 and and CC cord-263357-krvei97r 48 18 study study NN cord-263357-krvei97r 48 19 virus virus NN cord-263357-krvei97r 48 20 entry entry NN cord-263357-krvei97r 48 21 . . . cord-263357-krvei97r 49 1 Antisera Antisera NNP cord-263357-krvei97r 49 2 raised raise VBD cord-263357-krvei97r 49 3 against against IN cord-263357-krvei97r 49 4 the the DT cord-263357-krvei97r 49 5 recombinant recombinant JJ cord-263357-krvei97r 49 6 HCoV HCoV NNP cord-263357-krvei97r 49 7 - - HYPH cord-263357-krvei97r 49 8 EMC EMC NNP cord-263357-krvei97r 49 9 proteins protein NNS cord-263357-krvei97r 49 10 can can MD cord-263357-krvei97r 49 11 detect detect VB cord-263357-krvei97r 49 12 viral viral JJ cord-263357-krvei97r 49 13 antigens antigen NNS cord-263357-krvei97r 49 14 in in IN cord-263357-krvei97r 49 15 infected infected JJ cord-263357-krvei97r 49 16 cell cell NN cord-263357-krvei97r 49 17 cultures culture NNS cord-263357-krvei97r 49 18 and and CC cord-263357-krvei97r 49 19 infected infected JJ cord-263357-krvei97r 49 20 tissues tissue NNS cord-263357-krvei97r 49 21 of of IN cord-263357-krvei97r 49 22 humans human NNS cord-263357-krvei97r 49 23 or or CC cord-263357-krvei97r 49 24 animals animal NNS cord-263357-krvei97r 49 25 for for IN cord-263357-krvei97r 49 26 studies study NNS cord-263357-krvei97r 49 27 on on IN cord-263357-krvei97r 49 28 virus virus NN cord-263357-krvei97r 49 29 tissue tissue NN cord-263357-krvei97r 49 30 tropism tropism NN cord-263357-krvei97r 49 31 and and CC cord-263357-krvei97r 49 32 pathogenesis pathogenesis NN cord-263357-krvei97r 49 33 . . . cord-263357-krvei97r 50 1 The the DT cord-263357-krvei97r 50 2 viral viral JJ cord-263357-krvei97r 50 3 genome genome NN cord-263357-krvei97r 50 4 can can MD cord-263357-krvei97r 50 5 now now RB cord-263357-krvei97r 50 6 be be VB cord-263357-krvei97r 50 7 reconstructed reconstruct VBN cord-263357-krvei97r 50 8 by by IN cord-263357-krvei97r 50 9 synthetic synthetic JJ cord-263357-krvei97r 50 10 biology biology NN cord-263357-krvei97r 50 11 to to TO cord-263357-krvei97r 50 12 create create VB cord-263357-krvei97r 50 13 a a DT cord-263357-krvei97r 50 14 manipulable manipulable JJ cord-263357-krvei97r 50 15 cDNA cdna NN cord-263357-krvei97r 50 16 copy copy NN cord-263357-krvei97r 50 17 that that WDT cord-263357-krvei97r 50 18 can can MD cord-263357-krvei97r 50 19 be be VB cord-263357-krvei97r 50 20 mutated mutate VBN cord-263357-krvei97r 50 21 for for IN cord-263357-krvei97r 50 22 analysis analysis NN cord-263357-krvei97r 50 23 of of IN cord-263357-krvei97r 50 24 virus virus NN cord-263357-krvei97r 50 25 replication replication NN cord-263357-krvei97r 50 26 , , , cord-263357-krvei97r 50 27 pathogenesis pathogenesis NN cord-263357-krvei97r 50 28 , , , cord-263357-krvei97r 50 29 virulence virulence NN cord-263357-krvei97r 50 30 factors factor NNS cord-263357-krvei97r 50 31 , , , cord-263357-krvei97r 50 32 host host NN cord-263357-krvei97r 50 33 range range NN cord-263357-krvei97r 50 34 , , , cord-263357-krvei97r 50 35 and and CC cord-263357-krvei97r 50 36 vaccines vaccine NNS cord-263357-krvei97r 50 37 . . . cord-263357-krvei97r 51 1 When when WRB cord-263357-krvei97r 51 2 additional additional JJ cord-263357-krvei97r 51 3 virus virus NN cord-263357-krvei97r 51 4 isolates isolate VBZ cord-263357-krvei97r 51 5 from from IN cord-263357-krvei97r 51 6 other other JJ cord-263357-krvei97r 51 7 patients patient NNS cord-263357-krvei97r 51 8 or or CC cord-263357-krvei97r 51 9 animal animal NN cord-263357-krvei97r 51 10 reservoirs reservoir NNS cord-263357-krvei97r 51 11 become become VBP cord-263357-krvei97r 51 12 available available JJ cord-263357-krvei97r 51 13 , , , cord-263357-krvei97r 51 14 genomic genomic JJ cord-263357-krvei97r 51 15 analysis analysis NN cord-263357-krvei97r 51 16 can can MD cord-263357-krvei97r 51 17 be be VB cord-263357-krvei97r 51 18 used use VBN cord-263357-krvei97r 51 19 to to TO cord-263357-krvei97r 51 20 analyze analyze VB cord-263357-krvei97r 51 21 variants variant NNS cord-263357-krvei97r 51 22 to to TO cord-263357-krvei97r 51 23 detect detect VB cord-263357-krvei97r 51 24 amino amino NN cord-263357-krvei97r 51 25 acid acid NN cord-263357-krvei97r 51 26 substitutions substitution NNS cord-263357-krvei97r 51 27 in in IN cord-263357-krvei97r 51 28 the the DT cord-263357-krvei97r 51 29 spike spike NN cord-263357-krvei97r 51 30 or or CC cord-263357-krvei97r 51 31 other other JJ cord-263357-krvei97r 51 32 proteins protein NNS cord-263357-krvei97r 51 33 that that WDT cord-263357-krvei97r 51 34 are be VBP cord-263357-krvei97r 51 35 associated associate VBN cord-263357-krvei97r 51 36 with with IN cord-263357-krvei97r 51 37 adaptation adaptation NN cord-263357-krvei97r 51 38 to to IN cord-263357-krvei97r 51 39 cell cell NN cord-263357-krvei97r 51 40 culture culture NN cord-263357-krvei97r 51 41 or or CC cord-263357-krvei97r 51 42 changes change NNS cord-263357-krvei97r 51 43 in in IN cord-263357-krvei97r 51 44 antigenicity antigenicity NN cord-263357-krvei97r 51 45 , , , cord-263357-krvei97r 51 46 host host NN cord-263357-krvei97r 51 47 range range NN cord-263357-krvei97r 51 48 , , , cord-263357-krvei97r 51 49 and and CC cord-263357-krvei97r 51 50 virulence virulence NN cord-263357-krvei97r 51 51 . . . cord-263357-krvei97r 52 1 What what WDT cord-263357-krvei97r 52 2 questions question NNS cord-263357-krvei97r 52 3 must must MD cord-263357-krvei97r 52 4 be be VB cord-263357-krvei97r 52 5 answered answer VBN cord-263357-krvei97r 52 6 to to TO cord-263357-krvei97r 52 7 show show VB cord-263357-krvei97r 52 8 whether whether IN cord-263357-krvei97r 52 9 HCoV HCoV NNP cord-263357-krvei97r 52 10 - - HYPH cord-263357-krvei97r 52 11 EMC EMC NNP cord-263357-krvei97r 52 12 is be VBZ cord-263357-krvei97r 52 13 likely likely JJ cord-263357-krvei97r 52 14 to to TO cord-263357-krvei97r 52 15 cause cause VB cord-263357-krvei97r 52 16 an an DT cord-263357-krvei97r 52 17 epidemic epidemic NN cord-263357-krvei97r 52 18 or or CC cord-263357-krvei97r 52 19 adapt adapt VB cord-263357-krvei97r 52 20 to to TO cord-263357-krvei97r 52 21 become become VB cord-263357-krvei97r 52 22 endemic endemic JJ cord-263357-krvei97r 52 23 in in IN cord-263357-krvei97r 52 24 humans human NNS cord-263357-krvei97r 52 25 ? ? . cord-263357-krvei97r 53 1 First first RB cord-263357-krvei97r 53 2 , , , cord-263357-krvei97r 53 3 it -PRON- PRP cord-263357-krvei97r 53 4 is be VBZ cord-263357-krvei97r 53 5 necessary necessary JJ cord-263357-krvei97r 53 6 to to TO cord-263357-krvei97r 53 7 prove prove VB cord-263357-krvei97r 53 8 whether whether IN cord-263357-krvei97r 53 9 the the DT cord-263357-krvei97r 53 10 HCoV HCoV NNP cord-263357-krvei97r 53 11 - - HYPH cord-263357-krvei97r 53 12 EMC EMC NNP cord-263357-krvei97r 53 13 cultured culture VBN cord-263357-krvei97r 53 14 from from IN cord-263357-krvei97r 53 15 the the DT cord-263357-krvei97r 53 16 first first JJ cord-263357-krvei97r 53 17 patient patient NN cord-263357-krvei97r 53 18 actually actually RB cord-263357-krvei97r 53 19 caused cause VBD cord-263357-krvei97r 53 20 his -PRON- PRP$ cord-263357-krvei97r 53 21 fatal fatal JJ cord-263357-krvei97r 53 22 disease disease NN cord-263357-krvei97r 53 23 ( ( -LRB- cord-263357-krvei97r 53 24 7 7 CD cord-263357-krvei97r 53 25 ) ) -RRB- cord-263357-krvei97r 53 26 . . . cord-263357-krvei97r 54 1 Several several JJ cord-263357-krvei97r 54 2 bacterial bacterial JJ cord-263357-krvei97r 54 3 pathogens pathogen NNS cord-263357-krvei97r 54 4 were be VBD cord-263357-krvei97r 54 5 also also RB cord-263357-krvei97r 54 6 cultured culture VBN cord-263357-krvei97r 54 7 from from IN cord-263357-krvei97r 54 8 his -PRON- PRP$ cord-263357-krvei97r 54 9 respiratory respiratory JJ cord-263357-krvei97r 54 10 tract tract NN cord-263357-krvei97r 54 11 , , , cord-263357-krvei97r 54 12 although although IN cord-263357-krvei97r 54 13 this this DT cord-263357-krvei97r 54 14 is be VBZ cord-263357-krvei97r 54 15 not not RB cord-263357-krvei97r 54 16 uncommon uncommon JJ cord-263357-krvei97r 54 17 in in IN cord-263357-krvei97r 54 18 severely severely RB cord-263357-krvei97r 54 19 ill ill JJ cord-263357-krvei97r 54 20 patients patient NNS cord-263357-krvei97r 54 21 on on IN cord-263357-krvei97r 54 22 respirators respirator NNS cord-263357-krvei97r 54 23 . . . cord-263357-krvei97r 55 1 Development development NN cord-263357-krvei97r 55 2 of of IN cord-263357-krvei97r 55 3 an an DT cord-263357-krvei97r 55 4 animal animal NN cord-263357-krvei97r 55 5 model model NN cord-263357-krvei97r 55 6 for for IN cord-263357-krvei97r 55 7 HCoVinduced hcovinduced JJ cord-263357-krvei97r 55 8 respiratory respiratory JJ cord-263357-krvei97r 55 9 disease disease NN cord-263357-krvei97r 55 10 would would MD cord-263357-krvei97r 55 11 fulfill fulfill VB cord-263357-krvei97r 55 12 Koch Koch NNP cord-263357-krvei97r 55 13 's 's POS cord-263357-krvei97r 55 14 postulates postulate NNS cord-263357-krvei97r 55 15 and and CC cord-263357-krvei97r 55 16 be be VB cord-263357-krvei97r 55 17 useful useful JJ cord-263357-krvei97r 55 18 for for IN cord-263357-krvei97r 55 19 testing test VBG cord-263357-krvei97r 55 20 candidate candidate NN cord-263357-krvei97r 55 21 coronavirus coronavirus NN cord-263357-krvei97r 55 22 drugs drug NNS cord-263357-krvei97r 55 23 and and CC cord-263357-krvei97r 55 24 vaccine vaccine NN cord-263357-krvei97r 55 25 strategies strategy NNS cord-263357-krvei97r 55 26 . . . cord-263357-krvei97r 56 1 Sera Sera NNP cord-263357-krvei97r 56 2 from from IN cord-263357-krvei97r 56 3 humans human NNS cord-263357-krvei97r 56 4 in in IN cord-263357-krvei97r 56 5 the the DT cord-263357-krvei97r 56 6 Middle Middle NNP cord-263357-krvei97r 56 7 East East NNP cord-263357-krvei97r 56 8 and and CC cord-263357-krvei97r 56 9 elsewhere elsewhere RB cord-263357-krvei97r 56 10 are be VBP cord-263357-krvei97r 56 11 being be VBG cord-263357-krvei97r 56 12 tested test VBN cord-263357-krvei97r 56 13 by by IN cord-263357-krvei97r 56 14 ELISA ELISA NNP cord-263357-krvei97r 56 15 for for IN cord-263357-krvei97r 56 16 HCoV HCoV NNP cord-263357-krvei97r 56 17 - - HYPH cord-263357-krvei97r 56 18 EMC EMC NNP cord-263357-krvei97r 56 19 - - HYPH cord-263357-krvei97r 56 20 specific specific JJ cord-263357-krvei97r 56 21 antibodies antibody NNS cord-263357-krvei97r 56 22 to to TO cord-263357-krvei97r 56 23 determine determine VB cord-263357-krvei97r 56 24 the the DT cord-263357-krvei97r 56 25 prevalence prevalence NN cord-263357-krvei97r 56 26 of of IN cord-263357-krvei97r 56 27 infection infection NN cord-263357-krvei97r 56 28 of of IN cord-263357-krvei97r 56 29 humans human NNS cord-263357-krvei97r 56 30 in in IN cord-263357-krvei97r 56 31 different different JJ cord-263357-krvei97r 56 32 regions region NNS cord-263357-krvei97r 56 33 and and CC cord-263357-krvei97r 56 34 estimate estimate VB cord-263357-krvei97r 56 35 the the DT cord-263357-krvei97r 56 36 percentage percentage NN cord-263357-krvei97r 56 37 of of IN cord-263357-krvei97r 56 38 clinically clinically RB cord-263357-krvei97r 56 39 apparent apparent JJ cord-263357-krvei97r 56 40 HCoV HCoV NNP cord-263357-krvei97r 56 41 - - HYPH cord-263357-krvei97r 56 42 EMC EMC NNP cord-263357-krvei97r 56 43 infections infection NNS cord-263357-krvei97r 56 44 and and CC cord-263357-krvei97r 56 45 the the DT cord-263357-krvei97r 56 46 case case NN cord-263357-krvei97r 56 47 / / SYM cord-263357-krvei97r 56 48 fatality fatality NN cord-263357-krvei97r 56 49 ratio ratio NN cord-263357-krvei97r 56 50 . . . cord-263357-krvei97r 57 1 Surveillance surveillance NN cord-263357-krvei97r 57 2 of of IN cord-263357-krvei97r 57 3 bats bat NNS cord-263357-krvei97r 57 4 and and CC cord-263357-krvei97r 57 5 other other JJ cord-263357-krvei97r 57 6 animals animal NNS cord-263357-krvei97r 57 7 in in IN cord-263357-krvei97r 57 8 the the DT cord-263357-krvei97r 57 9 Middle Middle NNP cord-263357-krvei97r 57 10 East East NNP cord-263357-krvei97r 57 11 and and CC cord-263357-krvei97r 57 12 elsewhere elsewhere RB cord-263357-krvei97r 57 13 for for IN cord-263357-krvei97r 57 14 the the DT cord-263357-krvei97r 57 15 presence presence NN cord-263357-krvei97r 57 16 of of IN cord-263357-krvei97r 57 17 RNA RNA NNP cord-263357-krvei97r 57 18 from from IN cord-263357-krvei97r 57 19 betacoronavirus betacoronavirus NNP cord-263357-krvei97r 57 20 lineage lineage NN cord-263357-krvei97r 57 21 c c NNP cord-263357-krvei97r 57 22 viruses virus NNS cord-263357-krvei97r 57 23 or or CC cord-263357-krvei97r 57 24 antibodies antibody NNS cord-263357-krvei97r 57 25 to to IN cord-263357-krvei97r 57 26 these these DT cord-263357-krvei97r 57 27 viruses virus NNS cord-263357-krvei97r 57 28 will will MD cord-263357-krvei97r 57 29 help help VB cord-263357-krvei97r 57 30 to to TO cord-263357-krvei97r 57 31 identify identify VB cord-263357-krvei97r 57 32 reservoir reservoir NN cord-263357-krvei97r 57 33 hosts host NNS cord-263357-krvei97r 57 34 and and CC cord-263357-krvei97r 57 35 possible possible JJ cord-263357-krvei97r 57 36 intermediate intermediate JJ cord-263357-krvei97r 57 37 hosts host NNS cord-263357-krvei97r 57 38 that that WDT cord-263357-krvei97r 57 39 could could MD cord-263357-krvei97r 57 40 transmit transmit VB cord-263357-krvei97r 57 41 the the DT cord-263357-krvei97r 57 42 virus virus NN cord-263357-krvei97r 57 43 to to IN cord-263357-krvei97r 57 44 humans human NNS cord-263357-krvei97r 57 45 . . . cord-263357-krvei97r 58 1 So so RB cord-263357-krvei97r 58 2 far far RB cord-263357-krvei97r 58 3 , , , cord-263357-krvei97r 58 4 no no DT cord-263357-krvei97r 58 5 epidemiological epidemiological JJ cord-263357-krvei97r 58 6 connections connection NNS cord-263357-krvei97r 58 7 have have VBP cord-263357-krvei97r 58 8 been be VBN cord-263357-krvei97r 58 9 found find VBN cord-263357-krvei97r 58 10 between between IN cord-263357-krvei97r 58 11 animals animal NNS cord-263357-krvei97r 58 12 and and CC cord-263357-krvei97r 58 13 the the DT cord-263357-krvei97r 58 14 HCoV HCoV NNP cord-263357-krvei97r 58 15 - - HYPH cord-263357-krvei97r 58 16 EMC EMC NNP cord-263357-krvei97r 58 17 patients patient NNS cord-263357-krvei97r 58 18 . . . cord-263357-krvei97r 59 1 This this DT cord-263357-krvei97r 59 2 virus virus NN cord-263357-krvei97r 59 3 is be VBZ cord-263357-krvei97r 59 4 apparently apparently RB cord-263357-krvei97r 59 5 much much RB cord-263357-krvei97r 59 6 less less RBR cord-263357-krvei97r 59 7 easily easily RB cord-263357-krvei97r 59 8 transmitted transmit VBN cord-263357-krvei97r 59 9 from from IN cord-263357-krvei97r 59 10 human human JJ cord-263357-krvei97r 59 11 to to IN cord-263357-krvei97r 59 12 human human NN cord-263357-krvei97r 59 13 than than IN cord-263357-krvei97r 59 14 SARS SARS NNP cord-263357-krvei97r 59 15 - - HYPH cord-263357-krvei97r 59 16 CoV CoV NNP cord-263357-krvei97r 59 17 , , , cord-263357-krvei97r 59 18 although although IN cord-263357-krvei97r 59 19 three three CD cord-263357-krvei97r 59 20 of of IN cord-263357-krvei97r 59 21 the the DT cord-263357-krvei97r 59 22 cases case NNS cord-263357-krvei97r 59 23 in in IN cord-263357-krvei97r 59 24 Saudi Saudi NNP cord-263357-krvei97r 59 25 Arabia Arabia NNP cord-263357-krvei97r 59 26 were be VBD cord-263357-krvei97r 59 27 within within IN cord-263357-krvei97r 59 28 one one CD cord-263357-krvei97r 59 29 family family NN cord-263357-krvei97r 59 30 and and CC cord-263357-krvei97r 59 31 several several JJ cord-263357-krvei97r 59 32 health health NN cord-263357-krvei97r 59 33 care care NN cord-263357-krvei97r 59 34 workers worker NNS cord-263357-krvei97r 59 35 who who WP cord-263357-krvei97r 59 36 cared care VBD cord-263357-krvei97r 59 37 for for IN cord-263357-krvei97r 59 38 two two CD cord-263357-krvei97r 59 39 of of IN cord-263357-krvei97r 59 40 the the DT cord-263357-krvei97r 59 41 confirmed confirm VBN cord-263357-krvei97r 59 42 cases case NNS cord-263357-krvei97r 59 43 in in IN cord-263357-krvei97r 59 44 Jordan Jordan NNP cord-263357-krvei97r 59 45 also also RB cord-263357-krvei97r 59 46 developed develop VBD cord-263357-krvei97r 59 47 pneumonia pneumonia NN cord-263357-krvei97r 59 48 and and CC cord-263357-krvei97r 59 49 are be VBP cord-263357-krvei97r 59 50 now now RB cord-263357-krvei97r 59 51 considered consider VBN cord-263357-krvei97r 59 52 probable probable JJ cord-263357-krvei97r 59 53 cases case NNS cord-263357-krvei97r 59 54 ( ( -LRB- cord-263357-krvei97r 59 55 5 5 CD cord-263357-krvei97r 59 56 ) ) -RRB- cord-263357-krvei97r 59 57 . . . cord-263357-krvei97r 60 1 It -PRON- PRP cord-263357-krvei97r 60 2 is be VBZ cord-263357-krvei97r 60 3 possible possible JJ cord-263357-krvei97r 60 4 that that IN cord-263357-krvei97r 60 5 as as IN cord-263357-krvei97r 60 6 the the DT cord-263357-krvei97r 60 7 virus virus NN cord-263357-krvei97r 60 8 replicates replicate VBZ cord-263357-krvei97r 60 9 in in IN cord-263357-krvei97r 60 10 sporadic sporadic JJ cord-263357-krvei97r 60 11 cases case NNS cord-263357-krvei97r 60 12 , , , cord-263357-krvei97r 60 13 mutations mutation NNS cord-263357-krvei97r 60 14 , , , cord-263357-krvei97r 60 15 particularly particularly RB cord-263357-krvei97r 60 16 in in IN cord-263357-krvei97r 60 17 the the DT cord-263357-krvei97r 60 18 genes gene NNS cord-263357-krvei97r 60 19 encoding encode VBG cord-263357-krvei97r 60 20 the the DT cord-263357-krvei97r 60 21 spike spike NN cord-263357-krvei97r 60 22 protein protein NN cord-263357-krvei97r 60 23 and and CC cord-263357-krvei97r 60 24 any any DT cord-263357-krvei97r 60 25 immunomodulatory immunomodulatory JJ cord-263357-krvei97r 60 26 proteins protein NNS cord-263357-krvei97r 60 27 , , , cord-263357-krvei97r 60 28 might may MD cord-263357-krvei97r 60 29 be be VB cord-263357-krvei97r 60 30 selected select VBN cord-263357-krvei97r 60 31 that that IN cord-263357-krvei97r 60 32 increase increase VB cord-263357-krvei97r 60 33 human human NN cord-263357-krvei97r 60 34 - - HYPH cord-263357-krvei97r 60 35 to to IN cord-263357-krvei97r 60 36 - - HYPH cord-263357-krvei97r 60 37 human human JJ cord-263357-krvei97r 60 38 transmissibility transmissibility NN cord-263357-krvei97r 60 39 . . . cord-263357-krvei97r 61 1 Sporadic sporadic JJ cord-263357-krvei97r 61 2 HCoV HCoV NNP cord-263357-krvei97r 61 3 - - HYPH cord-263357-krvei97r 61 4 EMC EMC NNP cord-263357-krvei97r 61 5 infections infection NNS cord-263357-krvei97r 61 6 in in IN cord-263357-krvei97r 61 7 epidemiologically epidemiologically RB cord-263357-krvei97r 61 8 unlinked unlinked JJ cord-263357-krvei97r 61 9 individuals individual NNS cord-263357-krvei97r 61 10 in in IN cord-263357-krvei97r 61 11 the the DT cord-263357-krvei97r 61 12 Middle Middle NNP cord-263357-krvei97r 61 13 East East NNP cord-263357-krvei97r 61 14 suggest suggest VBP cord-263357-krvei97r 61 15 that that IN cord-263357-krvei97r 61 16 it -PRON- PRP cord-263357-krvei97r 61 17 is be VBZ cord-263357-krvei97r 61 18 a a DT cord-263357-krvei97r 61 19 zoonotic zoonotic JJ cord-263357-krvei97r 61 20 virus virus NN cord-263357-krvei97r 61 21 . . . cord-263357-krvei97r 62 1 Where where WRB cord-263357-krvei97r 62 2 encounters encounter NNS cord-263357-krvei97r 62 3 between between IN cord-263357-krvei97r 62 4 humans human NNS cord-263357-krvei97r 62 5 and and CC cord-263357-krvei97r 62 6 wildlife wildlife NN cord-263357-krvei97r 62 7 have have VBP cord-263357-krvei97r 62 8 become become VBN cord-263357-krvei97r 62 9 common common JJ cord-263357-krvei97r 62 10 , , , cord-263357-krvei97r 62 11 sporadic sporadic JJ cord-263357-krvei97r 62 12 zoonotic zoonotic JJ cord-263357-krvei97r 62 13 infections infection NNS cord-263357-krvei97r 62 14 may may MD cord-263357-krvei97r 62 15 occur occur VB cord-263357-krvei97r 62 16 without without IN cord-263357-krvei97r 62 17 human human NN cord-263357-krvei97r 62 18 - - HYPH cord-263357-krvei97r 62 19 to to IN cord-263357-krvei97r 62 20 - - HYPH cord-263357-krvei97r 62 21 human human JJ cord-263357-krvei97r 62 22 transmission transmission NN cord-263357-krvei97r 62 23 . . . cord-263357-krvei97r 63 1 This this DT cord-263357-krvei97r 63 2 so so RB cord-263357-krvei97r 63 3 - - HYPH cord-263357-krvei97r 63 4 called call VBN cord-263357-krvei97r 63 5 " " `` cord-263357-krvei97r 63 6 virus virus NN cord-263357-krvei97r 63 7 chatter chatter NN cord-263357-krvei97r 63 8 " " '' cord-263357-krvei97r 63 9 was be VBD cord-263357-krvei97r 63 10 obvious obvious JJ cord-263357-krvei97r 63 11 in in IN cord-263357-krvei97r 63 12 retrospective retrospective JJ cord-263357-krvei97r 63 13 studies study NNS cord-263357-krvei97r 63 14 of of IN cord-263357-krvei97r 63 15 SARS SARS NNP cord-263357-krvei97r 63 16 - - HYPH cord-263357-krvei97r 63 17 CoV CoV NNP cord-263357-krvei97r 63 18 infections infection NNS cord-263357-krvei97r 63 19 in in IN cord-263357-krvei97r 63 20 China China NNP cord-263357-krvei97r 63 21 which which WDT cord-263357-krvei97r 63 22 showed show VBD cord-263357-krvei97r 63 23 that that IN cord-263357-krvei97r 63 24 isolated isolate VBN cord-263357-krvei97r 63 25 cases case NNS cord-263357-krvei97r 63 26 occurred occur VBD cord-263357-krvei97r 63 27 well well RB cord-263357-krvei97r 63 28 before before IN cord-263357-krvei97r 63 29 the the DT cord-263357-krvei97r 63 30 virus virus NN cord-263357-krvei97r 63 31 began begin VBD cord-263357-krvei97r 63 32 to to TO cord-263357-krvei97r 63 33 spread spread VB cord-263357-krvei97r 63 34 from from IN cord-263357-krvei97r 63 35 human human JJ cord-263357-krvei97r 63 36 to to IN cord-263357-krvei97r 63 37 human human NN cord-263357-krvei97r 63 38 during during IN cord-263357-krvei97r 63 39 the the DT cord-263357-krvei97r 63 40 SARS SARS NNP cord-263357-krvei97r 63 41 pandemic pandemic NN cord-263357-krvei97r 63 42 ( ( -LRB- cord-263357-krvei97r 63 43 8) 8) NNP cord-263357-krvei97r 63 44 ( ( -LRB- cord-263357-krvei97r 63 45 9 9 CD cord-263357-krvei97r 63 46 ) ) -RRB- cord-263357-krvei97r 63 47 ( ( -LRB- cord-263357-krvei97r 63 48 10 10 CD cord-263357-krvei97r 63 49 ) ) -RRB- cord-263357-krvei97r 63 50 . . . cord-263357-krvei97r 64 1 Mutations mutation NNS cord-263357-krvei97r 64 2 in in IN cord-263357-krvei97r 64 3 the the DT cord-263357-krvei97r 64 4 SARS SARS NNP cord-263357-krvei97r 64 5 - - HYPH cord-263357-krvei97r 64 6 CoV CoV NNP cord-263357-krvei97r 64 7 spike spike NN cord-263357-krvei97r 64 8 protein protein NN cord-263357-krvei97r 64 9 and and CC cord-263357-krvei97r 64 10 other other JJ cord-263357-krvei97r 64 11 viral viral JJ cord-263357-krvei97r 64 12 proteins protein NNS cord-263357-krvei97r 64 13 were be VBD cord-263357-krvei97r 64 14 associated associate VBN cord-263357-krvei97r 64 15 with with IN cord-263357-krvei97r 64 16 the the DT cord-263357-krvei97r 64 17 transition transition NN cord-263357-krvei97r 64 18 from from IN cord-263357-krvei97r 64 19 " " `` cord-263357-krvei97r 64 20 chatter chatter NN cord-263357-krvei97r 64 21 " " '' cord-263357-krvei97r 64 22 to to IN cord-263357-krvei97r 64 23 epidemic epidemic NN cord-263357-krvei97r 64 24 . . . cord-263357-krvei97r 65 1 It -PRON- PRP cord-263357-krvei97r 65 2 is be VBZ cord-263357-krvei97r 65 3 possible possible JJ cord-263357-krvei97r 65 4 that that IN cord-263357-krvei97r 65 5 HCoV HCoV NNP cord-263357-krvei97r 65 6 - - HYPH cord-263357-krvei97r 65 7 EMC EMC NNP cord-263357-krvei97r 65 8 is be VBZ cord-263357-krvei97r 65 9 not not RB cord-263357-krvei97r 65 10 yet yet RB cord-263357-krvei97r 65 11 a a DT cord-263357-krvei97r 65 12 human human NN cord-263357-krvei97r 65 13 - - HYPH cord-263357-krvei97r 65 14 adapted adapt VBN cord-263357-krvei97r 65 15 virus virus NN cord-263357-krvei97r 65 16 and and CC cord-263357-krvei97r 65 17 has have VBZ cord-263357-krvei97r 65 18 simply simply RB cord-263357-krvei97r 65 19 been be VBN cord-263357-krvei97r 65 20 detected detect VBN cord-263357-krvei97r 65 21 in in IN cord-263357-krvei97r 65 22 rare rare JJ cord-263357-krvei97r 65 23 cases case NNS cord-263357-krvei97r 65 24 of of IN cord-263357-krvei97r 65 25 " " `` cord-263357-krvei97r 65 26 chatter chatter NN cord-263357-krvei97r 65 27 " " '' cord-263357-krvei97r 65 28 by by IN cord-263357-krvei97r 65 29 increasingly increasingly RB cord-263357-krvei97r 65 30 sophisticated sophisticated JJ cord-263357-krvei97r 65 31 surveillance surveillance NN cord-263357-krvei97r 65 32 . . . cord-263357-krvei97r 66 1 The the DT cord-263357-krvei97r 66 2 work work NN cord-263357-krvei97r 66 3 by by IN cord-263357-krvei97r 66 4 van van NNP cord-263357-krvei97r 66 5 Boheemen Boheemen NNP cord-263357-krvei97r 66 6 et et NNP cord-263357-krvei97r 66 7 al al NNP cord-263357-krvei97r 66 8 . . NNP cord-263357-krvei97r 66 9 demonstrates demonstrate VBZ cord-263357-krvei97r 66 10 the the DT cord-263357-krvei97r 66 11 ability ability NN cord-263357-krvei97r 66 12 of of IN cord-263357-krvei97r 66 13 state state NN cord-263357-krvei97r 66 14 - - HYPH cord-263357-krvei97r 66 15 of of IN cord-263357-krvei97r 66 16 - - HYPH cord-263357-krvei97r 66 17 the the DT cord-263357-krvei97r 66 18 - - HYPH cord-263357-krvei97r 66 19 art art NN cord-263357-krvei97r 66 20 technology technology NN cord-263357-krvei97r 66 21 and and CC cord-263357-krvei97r 66 22 bioinformatics bioinformatic NNS cord-263357-krvei97r 66 23 to to TO cord-263357-krvei97r 66 24 obtain obtain VB cord-263357-krvei97r 66 25 full full JJ cord-263357-krvei97r 66 26 - - HYPH cord-263357-krvei97r 66 27 genome genome NN cord-263357-krvei97r 66 28 sequence sequence NN cord-263357-krvei97r 66 29 data datum NNS cord-263357-krvei97r 66 30 within within IN cord-263357-krvei97r 66 31 days day NNS cord-263357-krvei97r 66 32 and and CC cord-263357-krvei97r 66 33 provide provide VB cord-263357-krvei97r 66 34 critical critical JJ cord-263357-krvei97r 66 35 insight insight NN cord-263357-krvei97r 66 36 into into IN cord-263357-krvei97r 66 37 the the DT cord-263357-krvei97r 66 38 potential potential JJ cord-263357-krvei97r 66 39 risks risk NNS cord-263357-krvei97r 66 40 associated associate VBN cord-263357-krvei97r 66 41 with with IN cord-263357-krvei97r 66 42 novel novel JJ cord-263357-krvei97r 66 43 viral viral JJ cord-263357-krvei97r 66 44 pathogens pathogen NNS cord-263357-krvei97r 66 45 ( ( -LRB- cord-263357-krvei97r 66 46 6 6 CD cord-263357-krvei97r 66 47 ) ) -RRB- cord-263357-krvei97r 66 48 . . . cord-263357-krvei97r 67 1 Over over IN cord-263357-krvei97r 67 2 the the DT cord-263357-krvei97r 67 3 past past JJ cord-263357-krvei97r 67 4 decade decade NN cord-263357-krvei97r 67 5 , , , cord-263357-krvei97r 67 6 other other JJ cord-263357-krvei97r 67 7 advances advance NNS cord-263357-krvei97r 67 8 , , , cord-263357-krvei97r 67 9 including include VBG cord-263357-krvei97r 67 10 the the DT cord-263357-krvei97r 67 11 development development NN cord-263357-krvei97r 67 12 of of IN cord-263357-krvei97r 67 13 enhanced enhance VBN cord-263357-krvei97r 67 14 virus virus NN cord-263357-krvei97r 67 15 detection detection NN cord-263357-krvei97r 67 16 technologies technology NNS cord-263357-krvei97r 67 17 , , , cord-263357-krvei97r 67 18 surveillance surveillance NN cord-263357-krvei97r 67 19 programs program NNS cord-263357-krvei97r 67 20 , , , cord-263357-krvei97r 67 21 increased increase VBD cord-263357-krvei97r 67 22 global global JJ cord-263357-krvei97r 67 23 awareness awareness NN cord-263357-krvei97r 67 24 and and CC cord-263357-krvei97r 67 25 communication communication NN cord-263357-krvei97r 67 26 through through IN cord-263357-krvei97r 67 27 Internet internet NN cord-263357-krvei97r 67 28 - - HYPH cord-263357-krvei97r 67 29 based base VBN cord-263357-krvei97r 67 30 technologies technology NNS cord-263357-krvei97r 67 31 such such JJ cord-263357-krvei97r 67 32 as as IN cord-263357-krvei97r 67 33 ProMed ProMed NNP cord-263357-krvei97r 67 34 , , , cord-263357-krvei97r 67 35 real real JJ cord-263357-krvei97r 67 36 - - HYPH cord-263357-krvei97r 67 37 time time NN cord-263357-krvei97r 67 38 sharing sharing NN cord-263357-krvei97r 67 39 of of IN cord-263357-krvei97r 67 40 genome genome NN cord-263357-krvei97r 67 41 sequences sequence NNS cord-263357-krvei97r 67 42 in in IN cord-263357-krvei97r 67 43 GenBank GenBank NNP cord-263357-krvei97r 67 44 , , , cord-263357-krvei97r 67 45 and and CC cord-263357-krvei97r 67 46 Internet internet NN cord-263357-krvei97r 67 47 - - HYPH cord-263357-krvei97r 67 48 based base VBN cord-263357-krvei97r 67 49 publications publication NNS cord-263357-krvei97r 67 50 and and CC cord-263357-krvei97r 67 51 the the DT cord-263357-krvei97r 67 52 posting posting NN cord-263357-krvei97r 67 53 of of IN cord-263357-krvei97r 67 54 publications publication NNS cord-263357-krvei97r 67 55 in in IN cord-263357-krvei97r 67 56 advance advance NN cord-263357-krvei97r 67 57 of of IN cord-263357-krvei97r 67 58 printing printing NN cord-263357-krvei97r 67 59 , , , cord-263357-krvei97r 67 60 as as RB cord-263357-krvei97r 67 61 well well RB cord-263357-krvei97r 67 62 as as IN cord-263357-krvei97r 67 63 increasing increase VBG cord-263357-krvei97r 67 64 collaborations collaboration NNS cord-263357-krvei97r 67 65 between between IN cord-263357-krvei97r 67 66 researchers researcher NNS cord-263357-krvei97r 67 67 and and CC cord-263357-krvei97r 67 68 medical medical JJ cord-263357-krvei97r 67 69 and and CC cord-263357-krvei97r 67 70 veterinary veterinary JJ cord-263357-krvei97r 67 71 practitioners practitioner NNS cord-263357-krvei97r 67 72 such such JJ cord-263357-krvei97r 67 73 as as IN cord-263357-krvei97r 67 74 the the DT cord-263357-krvei97r 67 75 One One NNP cord-263357-krvei97r 67 76 Health Health NNP cord-263357-krvei97r 67 77 Initiative Initiative NNP cord-263357-krvei97r 67 78 , , , cord-263357-krvei97r 67 79 have have VBP cord-263357-krvei97r 67 80 greatly greatly RB cord-263357-krvei97r 67 81 facilitated facilitate VBN cord-263357-krvei97r 67 82 rapid rapid JJ cord-263357-krvei97r 67 83 and and CC cord-263357-krvei97r 67 84 effective effective JJ cord-263357-krvei97r 67 85 responses response NNS cord-263357-krvei97r 67 86 to to IN cord-263357-krvei97r 67 87 threats threat NNS cord-263357-krvei97r 67 88 of of IN cord-263357-krvei97r 67 89 new new JJ cord-263357-krvei97r 67 90 emerging emerge VBG cord-263357-krvei97r 67 91 infectious infectious JJ cord-263357-krvei97r 67 92 diseases disease NNS cord-263357-krvei97r 67 93 . . . cord-263357-krvei97r 68 1 Bats bat NNS cord-263357-krvei97r 68 2 are be VBP cord-263357-krvei97r 68 3 natural natural JJ cord-263357-krvei97r 68 4 reservoirs reservoir NNS cord-263357-krvei97r 68 5 of of IN cord-263357-krvei97r 68 6 SARS SARS NNP cord-263357-krvei97r 68 7 - - HYPH cord-263357-krvei97r 68 8 like like JJ cord-263357-krvei97r 68 9 coronaviruses coronaviruse NNS cord-263357-krvei97r 69 1 Severe severe JJ cord-263357-krvei97r 69 2 acute acute JJ cord-263357-krvei97r 69 3 respiratory respiratory JJ cord-263357-krvei97r 69 4 syndrome syndrome NN cord-263357-krvei97r 69 5 coronavirus coronavirus NN cord-263357-krvei97r 69 6 - - HYPH cord-263357-krvei97r 69 7 like like JJ cord-263357-krvei97r 69 8 Commentary commentary NN cord-263357-krvei97r 69 9 virus virus NN cord-263357-krvei97r 69 10 in in IN cord-263357-krvei97r 69 11 Chinese chinese JJ cord-263357-krvei97r 69 12 horseshoe horseshoe NN cord-263357-krvei97r 69 13 bats bat NNS cord-263357-krvei97r 69 14 Discovery Discovery NNP cord-263357-krvei97r 69 15 of of IN cord-263357-krvei97r 69 16 seven seven CD cord-263357-krvei97r 69 17 novel novel JJ cord-263357-krvei97r 69 18 mammalian mammalian JJ cord-263357-krvei97r 69 19 and and CC cord-263357-krvei97r 69 20 avian avian JJ cord-263357-krvei97r 69 21 coronaviruses coronaviruse NNS cord-263357-krvei97r 69 22 in in IN cord-263357-krvei97r 69 23 the the DT cord-263357-krvei97r 69 24 genus genus NN cord-263357-krvei97r 69 25 deltacoronavirus deltacoronavirus NNP cord-263357-krvei97r 69 26 supports support VBZ cord-263357-krvei97r 69 27 bat bat NN cord-263357-krvei97r 69 28 coronaviruses coronaviruse NNS cord-263357-krvei97r 69 29 as as IN cord-263357-krvei97r 69 30 the the DT cord-263357-krvei97r 69 31 gene gene NN cord-263357-krvei97r 69 32 source source NN cord-263357-krvei97r 69 33 of of IN cord-263357-krvei97r 69 34 alphacoronavirus alphacoronavirus NNP cord-263357-krvei97r 69 35 and and CC cord-263357-krvei97r 69 36 betacoronavirus betacoronavirus NNP cord-263357-krvei97r 69 37 and and CC cord-263357-krvei97r 69 38 avian avian JJ cord-263357-krvei97r 69 39 coronaviruses coronaviruse NNS cord-263357-krvei97r 69 40 as as IN cord-263357-krvei97r 69 41 the the DT cord-263357-krvei97r 69 42 gene gene NN cord-263357-krvei97r 69 43 source source NN cord-263357-krvei97r 69 44 of of IN cord-263357-krvei97r 69 45 gammacoronavirus gammacoronavirus NNP cord-263357-krvei97r 69 46 and and CC cord-263357-krvei97r 69 47 deltacoronavirus deltacoronavirus JJ cord-263357-krvei97r 69 48 Isolation isolation NN cord-263357-krvei97r 69 49 of of IN cord-263357-krvei97r 69 50 a a DT cord-263357-krvei97r 69 51 novel novel JJ cord-263357-krvei97r 69 52 coronavirus coronavirus NN cord-263357-krvei97r 69 53 from from IN cord-263357-krvei97r 69 54 a a DT cord-263357-krvei97r 69 55 man man NN cord-263357-krvei97r 69 56 with with IN cord-263357-krvei97r 69 57 pneumonia pneumonia NN cord-263357-krvei97r 69 58 in in IN cord-263357-krvei97r 69 59 Saudi Saudi NNP cord-263357-krvei97r 69 60 Arabia Arabia NNP cord-263357-krvei97r 69 61 World World NNP cord-263357-krvei97r 69 62 Health Health NNP cord-263357-krvei97r 69 63 Organization Organization NNP cord-263357-krvei97r 69 64 Global Global NNP cord-263357-krvei97r 69 65 Alert Alert NNP cord-263357-krvei97r 69 66 and and CC cord-263357-krvei97r 69 67 Response response NN cord-263357-krvei97r 69 68 . . . cord-263357-krvei97r 70 1 Background background NN cord-263357-krvei97r 70 2 and and CC cord-263357-krvei97r 70 3 summary summary NN cord-263357-krvei97r 70 4 of of IN cord-263357-krvei97r 70 5 novel novel JJ cord-263357-krvei97r 70 6 coronavirus coronavirus NN cord-263357-krvei97r 70 7 infection infection NN cord-263357-krvei97r 70 8 - - : cord-263357-krvei97r 70 9 as as IN cord-263357-krvei97r 70 10 of of IN cord-263357-krvei97r 70 11 Genomic genomic JJ cord-263357-krvei97r 70 12 characterization characterization NN cord-263357-krvei97r 70 13 of of IN cord-263357-krvei97r 70 14 a a DT cord-263357-krvei97r 70 15 newly newly RB cord-263357-krvei97r 70 16 discovered discover VBN cord-263357-krvei97r 70 17 coronavirus coronavirus NN cord-263357-krvei97r 70 18 associated associate VBN cord-263357-krvei97r 70 19 with with IN cord-263357-krvei97r 70 20 acute acute JJ cord-263357-krvei97r 70 21 respiratory respiratory JJ cord-263357-krvei97r 70 22 distress distress NN cord-263357-krvei97r 70 23 syndrome syndrome NN cord-263357-krvei97r 70 24 in in IN cord-263357-krvei97r 70 25 humans human NNS cord-263357-krvei97r 70 26 Microbe Microbe NNP cord-263357-krvei97r 70 27 hunting hunt VBG cord-263357-krvei97r 70 28 . . . cord-263357-krvei97r 71 1 Microbiol Microbiol NNP cord-263357-krvei97r 71 2 Cross Cross NNP cord-263357-krvei97r 71 3 - - JJ cord-263357-krvei97r 71 4 host host JJ cord-263357-krvei97r 71 5 evolution evolution NN cord-263357-krvei97r 71 6 of of IN cord-263357-krvei97r 71 7 severe severe JJ cord-263357-krvei97r 71 8 acute acute JJ cord-263357-krvei97r 71 9 respiratory respiratory JJ cord-263357-krvei97r 71 10 syndrome syndrome NN cord-263357-krvei97r 71 11 coronavirus coronavirus NN cord-263357-krvei97r 71 12 in in IN cord-263357-krvei97r 71 13 palm palm NN cord-263357-krvei97r 71 14 civet civet NN cord-263357-krvei97r 71 15 and and CC cord-263357-krvei97r 71 16 human human JJ cord-263357-krvei97r 71 17 Cross Cross NNP cord-263357-krvei97r 71 18 - - HYPH cord-263357-krvei97r 71 19 species species NNP cord-263357-krvei97r 71 20 virus virus NN cord-263357-krvei97r 71 21 transmission transmission NN cord-263357-krvei97r 71 22 and and CC cord-263357-krvei97r 71 23 the the DT cord-263357-krvei97r 71 24 emergence emergence NN cord-263357-krvei97r 71 25 of of IN cord-263357-krvei97r 71 26 new new JJ cord-263357-krvei97r 71 27 epidemic epidemic NN cord-263357-krvei97r 71 28 diseases disease NNS cord-263357-krvei97r 71 29 . . . cord-263357-krvei97r 72 1 Microbiol Microbiol NNP cord-263357-krvei97r 72 2 Bushmeat Bushmeat NNP cord-263357-krvei97r 72 3 hunting hunting NN cord-263357-krvei97r 72 4 , , , cord-263357-krvei97r 72 5 deforestation deforestation NN cord-263357-krvei97r 72 6 , , , cord-263357-krvei97r 72 7 and and CC cord-263357-krvei97r 72 8 prediction prediction NN cord-263357-krvei97r 72 9 of of IN cord-263357-krvei97r 72 10 zoonoses zoonosis NNS cord-263357-krvei97r 72 11 emergence emergence NN