id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-337492-o6sy4zi4	Baric, Ralph S.	Next-Generation High-Throughput Functional Annotation of Microbial Genomes	2016-10-04		.txt	text/plain	3026	144	34	The National Institute of Allergy and Infectious Diseases (NIAID) addressed this gap by creating functional genomics centers dedicated to developing high-throughput approaches to assign gene function. High-throughput functional genomics can lead to new therapeutics and better understanding of the next generation of emerging pathogens by rapidly defining new general mechanisms by which organisms cause disease and replicate in host tissues and by facilitating the rate at which functional data reach the scientific community. Unlike large-scale genome-sequencing or structural-genomics efforts, the functional annotation of uncharacterized genes is not well developed technologically, and therefore, the scientific community cannot rely on a well-defined, mature set of experimental approaches. The NIAID has implemented a program aimed at assigning functions to open reading frames (ORFs) and small noncoding RNAs (ncRNAs) that have been discovered by large-scale sequencing efforts to begin addressing this gap in our understanding of bacterial and viral gene function.	./cache/cord-337492-o6sy4zi4.txt	./txt/cord-337492-o6sy4zi4.txt