id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335938-hscgmis5	Gralinski, Lisa E.	Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury	2013-08-06		.txt	text/plain	7816	370	42	The results of these studies demonstrate that a fine balance exists between host coagulation and fibrinolysin pathways regulating pathological disease outcomes, including diffuse alveolar damage and acute lung injury, following infection with highly pathogenic respiratory viruses, such as SARS-CoV. To model system-wide behaviors following SARS-CoV infection, we performed a dose-response study that included biological sampling at multiple time points, transcriptional and proteomic systems biology data, and mathematical modeling algorithms to identify signaling networks associated with progression from severe to lethal disease outcomes. These data demonstrate the successful use of highly refined modeling algorithms to identify and validate novel genes and pathways that play critical roles in SARS-CoV pathogenesis and the development of ALI following virus infection in the lung. Similar changes in the urokinase, coagulation, and fibrinolysin pathway expression signatures are noted following highly pathogenic SARS-CoV and influenza virus infections (see Fig. S5B and S6 in the supplemental material), arguing for a con-served role for these pathways in virus-induced end-stage lung diseases, like ALI and ARDS.	./cache/cord-335938-hscgmis5.txt	./txt/cord-335938-hscgmis5.txt