id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002467-b0p1b4g8	Leyva-Grado, Victor H.	Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection	2017-03-28		.txt	text/plain	5948	297	43	Similarly, in wild-type mice infected with NL/09 virus, we P2X7 Receptor in Influenza Immunopathology ® observed a significant reduction in body weight at days 4 to 8 postinfection (P Ͻ 0.05) (Fig. 2C) . Reduced virus titers were observed in the lungs of the P2X7r KO mice compared to the wild-type mice, particularly in the samples collected on day 7 postinfection, although these differences were not statistically significant (P ϭ 0.1) (Fig. 3A) . In this study, we showed that mice lacking the purinergic receptor P2X7 have a better clinical outcome after influenza A virus infection characterized by an increased survival rate with an overall reduced immunopathology of the lungs compared to the wild-type mice. Activation of the purinergic receptor P2X7 signaling by increased levels of extracellular ATP caused by influenza virus infection leads to an exacerbated immune response characterized by increased production of proinflammatory cytokines, induction of apoptosis, increased influx of neutrophils in the airways, and development of lung histopathology.	./cache/cord-002467-b0p1b4g8.txt	./txt/cord-002467-b0p1b4g8.txt