id author title date pages extension mime words sentences flesch summary cache txt cord-001450-7vsdqhi0 Burgess, Stacey L. Bone Marrow Dendritic Cells from Mice with an Altered Microbiota Provide Interleukin 17A-Dependent Protection against Entamoeba histolytica Colitis 2014-11-04 .txt text/plain 3996 208 42 title: Bone Marrow Dendritic Cells from Mice with an Altered Microbiota Provide Interleukin 17A-Dependent Protection against Entamoeba histolytica Colitis Bone marrow-derived dendritic cells (BMDCs) from SFB-colonized mice had higher levels of IL-23 production in response to stimulation with trophozoites. It is also quite possible that mediators induced by the intestinal microbiota in the serum might influence the bone marrow in such a way as to prime DCs to provide protection against, or exacerbate, enteropathogen infections (27, 28) . histolytica colitis and that bone marrow dendritic cells (BM-DCs) derived from SFB-colonized mice were able to recapitulate protection in mice that had not been colonized with the bacteria. These data suggest that intestinal colonization with a commensal bacterium can alter bone marrow in such a way as to provide protection against parasite infection. Thus, as SFB increased frequency of intestinal DCs, IL-23, IL-17A expression, and circulating serum SAA, we examined the capacity of bone marrow DCs from SFB-infected mice to produce IL-23 in response to trophozoites. ./cache/cord-001450-7vsdqhi0.txt ./txt/cord-001450-7vsdqhi0.txt