id sid tid token lemma pos cord-292606-tqjmg3qb 1 1 key key JJ cord-292606-tqjmg3qb 2 1 : : : cord-292606-tqjmg3qb 2 2 cord-292606-tqjmg3qb cord-292606-tqjmg3qb ADD cord-292606-tqjmg3qb 2 3 authors author NNS cord-292606-tqjmg3qb 2 4 : : : cord-292606-tqjmg3qb 3 1 Testori Testori NNP cord-292606-tqjmg3qb 3 2 , , , cord-292606-tqjmg3qb 3 3 Alessandro Alessandro NNP cord-292606-tqjmg3qb 3 4 title title NN cord-292606-tqjmg3qb 3 5 : : : cord-292606-tqjmg3qb 3 6 THE the DT cord-292606-tqjmg3qb 3 7 “ " `` cord-292606-tqjmg3qb 3 8 PERFECT perfect JJ cord-292606-tqjmg3qb 3 9 CYTOKINE cytokine NN cord-292606-tqjmg3qb 3 10 STORM storm NN cord-292606-tqjmg3qb 3 11 ” " '' cord-292606-tqjmg3qb 3 12 OF of IN cord-292606-tqjmg3qb 3 13 COVID-19 covid-19 CD cord-292606-tqjmg3qb 3 14 date date NN cord-292606-tqjmg3qb 3 15 : : : cord-292606-tqjmg3qb 3 16 2020 2020 CD cord-292606-tqjmg3qb 3 17 - - HYPH cord-292606-tqjmg3qb 3 18 05 05 CD cord-292606-tqjmg3qb 3 19 - - HYPH cord-292606-tqjmg3qb 3 20 29 29 CD cord-292606-tqjmg3qb 3 21 journal journal NN cord-292606-tqjmg3qb 3 22 : : : cord-292606-tqjmg3qb 4 1 Mayo Mayo NNP cord-292606-tqjmg3qb 4 2 Clin Clin NNP cord-292606-tqjmg3qb 4 3 Proc Proc NNP cord-292606-tqjmg3qb 4 4 DOI DOI NNP cord-292606-tqjmg3qb 4 5 : : : cord-292606-tqjmg3qb 4 6 10.1016 10.1016 CD cord-292606-tqjmg3qb 4 7 / / SYM cord-292606-tqjmg3qb 4 8 j.mayocp.2020.05.015 j.mayocp.2020.05.015 CD cord-292606-tqjmg3qb 4 9 sha sha XX cord-292606-tqjmg3qb 4 10 : : : cord-292606-tqjmg3qb 5 1 839c4dafc426075c423c8142175b3d2a88df9c52 839c4dafc426075c423c8142175b3d2a88df9c52 NNP cord-292606-tqjmg3qb 5 2 doc_id doc_id CD cord-292606-tqjmg3qb 5 3 : : : cord-292606-tqjmg3qb 6 1 292606 292606 CD cord-292606-tqjmg3qb 6 2 cord_uid cord_uid NNS cord-292606-tqjmg3qb 6 3 : : : cord-292606-tqjmg3qb 7 1 tqjmg3qb tqjmg3qb NNP cord-292606-tqjmg3qb 8 1 nan nan NNP cord-292606-tqjmg3qb 8 2 I -PRON- PRP cord-292606-tqjmg3qb 8 3 have have VBP cord-292606-tqjmg3qb 8 4 read read VBN cord-292606-tqjmg3qb 8 5 with with IN cord-292606-tqjmg3qb 8 6 great great JJ cord-292606-tqjmg3qb 8 7 interest interest NN cord-292606-tqjmg3qb 8 8 the the DT cord-292606-tqjmg3qb 8 9 recent recent JJ cord-292606-tqjmg3qb 8 10 article article NN cord-292606-tqjmg3qb 8 11 by by IN cord-292606-tqjmg3qb 8 12 Vijayvargiva Vijayvargiva NNP cord-292606-tqjmg3qb 8 13 et et NNP cord-292606-tqjmg3qb 8 14 al al NNP cord-292606-tqjmg3qb 8 15 1 1 CD cord-292606-tqjmg3qb 8 16 _SP cord-292606-tqjmg3qb 8 17 Proceedings Proceedings NNP cord-292606-tqjmg3qb 8 18 . . . cord-292606-tqjmg3qb 9 1 The the DT cord-292606-tqjmg3qb 9 2 vast vast JJ cord-292606-tqjmg3qb 9 3 majority majority NN cord-292606-tqjmg3qb 9 4 of of IN cord-292606-tqjmg3qb 9 5 the the DT cord-292606-tqjmg3qb 9 6 deaths death NNS cord-292606-tqjmg3qb 9 7 caused cause VBN cord-292606-tqjmg3qb 9 8 by by IN cord-292606-tqjmg3qb 9 9 severe severe JJ cord-292606-tqjmg3qb 9 10 acute acute JJ cord-292606-tqjmg3qb 9 11 respiratory respiratory JJ cord-292606-tqjmg3qb 9 12 syndrome syndrome NN cord-292606-tqjmg3qb 9 13 Coronavirus Coronavirus NNP cord-292606-tqjmg3qb 9 14 2 2 CD cord-292606-tqjmg3qb 10 1 ( ( -LRB- cord-292606-tqjmg3qb 10 2 SARS SARS NNP cord-292606-tqjmg3qb 10 3 - - HYPH cord-292606-tqjmg3qb 10 4 CoV-2 CoV-2 NNP cord-292606-tqjmg3qb 10 5 ) ) -RRB- cord-292606-tqjmg3qb 10 6 are be VBP cord-292606-tqjmg3qb 10 7 patients patient NNS cord-292606-tqjmg3qb 10 8 over over IN cord-292606-tqjmg3qb 10 9 the the DT cord-292606-tqjmg3qb 10 10 age age NN cord-292606-tqjmg3qb 10 11 of of IN cord-292606-tqjmg3qb 10 12 55 55 CD cord-292606-tqjmg3qb 10 13 , , , cord-292606-tqjmg3qb 10 14 which which WDT cord-292606-tqjmg3qb 10 15 died die VBD cord-292606-tqjmg3qb 10 16 of of IN cord-292606-tqjmg3qb 10 17 Acute acute JJ cord-292606-tqjmg3qb 10 18 Respiratory Respiratory NNP cord-292606-tqjmg3qb 10 19 Distress Distress NNP cord-292606-tqjmg3qb 10 20 Syndrome Syndrome NNP cord-292606-tqjmg3qb 10 21 ( ( -LRB- cord-292606-tqjmg3qb 10 22 ARDS ARDS NNP cord-292606-tqjmg3qb 10 23 ) ) -RRB- cord-292606-tqjmg3qb 10 24 . . . cord-292606-tqjmg3qb 11 1 At at IN cord-292606-tqjmg3qb 11 2 the the DT cord-292606-tqjmg3qb 11 3 histological histological JJ cord-292606-tqjmg3qb 11 4 level level NN cord-292606-tqjmg3qb 11 5 ARDS ARDS NNP cord-292606-tqjmg3qb 11 6 is be VBZ cord-292606-tqjmg3qb 11 7 characterized characterize VBN cord-292606-tqjmg3qb 11 8 by by IN cord-292606-tqjmg3qb 11 9 an an DT cord-292606-tqjmg3qb 11 10 intense intense JJ cord-292606-tqjmg3qb 11 11 inflammatory inflammatory JJ cord-292606-tqjmg3qb 11 12 response response NN cord-292606-tqjmg3qb 11 13 occurring occur VBG cord-292606-tqjmg3qb 11 14 in in IN cord-292606-tqjmg3qb 11 15 the the DT cord-292606-tqjmg3qb 11 16 lungs lung NNS cord-292606-tqjmg3qb 11 17 of of IN cord-292606-tqjmg3qb 11 18 patients patient NNS cord-292606-tqjmg3qb 11 19 . . . cord-292606-tqjmg3qb 12 1 2 2 LS cord-292606-tqjmg3qb 12 2 Human human JJ cord-292606-tqjmg3qb 12 3 aging aging NN cord-292606-tqjmg3qb 12 4 is be VBZ cord-292606-tqjmg3qb 12 5 associated associate VBN cord-292606-tqjmg3qb 12 6 with with IN cord-292606-tqjmg3qb 12 7 an an DT cord-292606-tqjmg3qb 12 8 up up RB cord-292606-tqjmg3qb 12 9 - - HYPH cord-292606-tqjmg3qb 12 10 regulated regulate VBN cord-292606-tqjmg3qb 12 11 inflammatory inflammatory JJ cord-292606-tqjmg3qb 12 12 response response NN cord-292606-tqjmg3qb 12 13 . . . cord-292606-tqjmg3qb 13 1 3 3 LS cord-292606-tqjmg3qb 13 2 Inflammation inflammation NN cord-292606-tqjmg3qb 13 3 is be VBZ cord-292606-tqjmg3qb 13 4 involved involve VBN cord-292606-tqjmg3qb 13 5 in in IN cord-292606-tqjmg3qb 13 6 the the DT cord-292606-tqjmg3qb 13 7 mechanisms mechanism NNS cord-292606-tqjmg3qb 13 8 underlying underlie VBG cord-292606-tqjmg3qb 13 9 the the DT cord-292606-tqjmg3qb 13 10 pathogenesis pathogenesis NN cord-292606-tqjmg3qb 13 11 of of IN cord-292606-tqjmg3qb 13 12 several several JJ cord-292606-tqjmg3qb 13 13 age age NN cord-292606-tqjmg3qb 13 14 - - HYPH cord-292606-tqjmg3qb 13 15 associated associate VBN cord-292606-tqjmg3qb 13 16 diseases disease NNS cord-292606-tqjmg3qb 13 17 such such JJ cord-292606-tqjmg3qb 13 18 as as IN cord-292606-tqjmg3qb 13 19 cardiovascular cardiovascular JJ cord-292606-tqjmg3qb 13 20 disease disease NN cord-292606-tqjmg3qb 13 21 , , , cord-292606-tqjmg3qb 13 22 type type NN cord-292606-tqjmg3qb 13 23 2 2 CD cord-292606-tqjmg3qb 13 24 diabetes diabete NNS cord-292606-tqjmg3qb 13 25 , , , cord-292606-tqjmg3qb 13 26 Alzheimer Alzheimer NNP cord-292606-tqjmg3qb 13 27 disease disease NN cord-292606-tqjmg3qb 13 28 ( ( -LRB- cord-292606-tqjmg3qb 13 29 AD ad NN cord-292606-tqjmg3qb 13 30 ) ) -RRB- cord-292606-tqjmg3qb 13 31 , , , cord-292606-tqjmg3qb 13 32 Parkinson Parkinson NNP cord-292606-tqjmg3qb 13 33 disease disease NN cord-292606-tqjmg3qb 13 34 , , , cord-292606-tqjmg3qb 13 35 rheumatoid rheumatoid NN cord-292606-tqjmg3qb 13 36 arthritis arthritis NN cord-292606-tqjmg3qb 13 37 ( ( -LRB- cord-292606-tqjmg3qb 13 38 RA RA NNP cord-292606-tqjmg3qb 13 39 ) ) -RRB- cord-292606-tqjmg3qb 13 40 , , , cord-292606-tqjmg3qb 13 41 and and CC cord-292606-tqjmg3qb 13 42 osteoporosis osteoporosis NN cord-292606-tqjmg3qb 13 43 . . . cord-292606-tqjmg3qb 14 1 Elderly elderly JJ cord-292606-tqjmg3qb 14 2 individuals individual NNS cord-292606-tqjmg3qb 14 3 have have VBP cord-292606-tqjmg3qb 14 4 lost lose VBN cord-292606-tqjmg3qb 14 5 the the DT cord-292606-tqjmg3qb 14 6 ability ability NN cord-292606-tqjmg3qb 14 7 to to TO cord-292606-tqjmg3qb 14 8 control control VB cord-292606-tqjmg3qb 14 9 and and CC cord-292606-tqjmg3qb 14 10 contain contain VB cord-292606-tqjmg3qb 14 11 inflammatory inflammatory JJ cord-292606-tqjmg3qb 14 12 processes process NNS cord-292606-tqjmg3qb 14 13 to to IN cord-292606-tqjmg3qb 14 14 the the DT cord-292606-tqjmg3qb 14 15 same same JJ cord-292606-tqjmg3qb 14 16 degree degree NN cord-292606-tqjmg3qb 14 17 of of IN cord-292606-tqjmg3qb 14 18 which which WDT cord-292606-tqjmg3qb 14 19 younger young JJR cord-292606-tqjmg3qb 14 20 individuals individual NNS cord-292606-tqjmg3qb 14 21 are be VBP cord-292606-tqjmg3qb 14 22 capable capable JJ cord-292606-tqjmg3qb 14 23 . . . cord-292606-tqjmg3qb 15 1 The the DT cord-292606-tqjmg3qb 15 2 innate innate JJ cord-292606-tqjmg3qb 15 3 immune immune JJ cord-292606-tqjmg3qb 15 4 system system NN cord-292606-tqjmg3qb 15 5 plays play VBZ cord-292606-tqjmg3qb 15 6 a a DT cord-292606-tqjmg3qb 15 7 central central JJ cord-292606-tqjmg3qb 15 8 role role NN cord-292606-tqjmg3qb 15 9 in in IN cord-292606-tqjmg3qb 15 10 inflammation inflammation NN cord-292606-tqjmg3qb 15 11 and and CC cord-292606-tqjmg3qb 15 12 is be VBZ cord-292606-tqjmg3qb 15 13 also also RB cord-292606-tqjmg3qb 15 14 key key JJ cord-292606-tqjmg3qb 15 15 in in IN cord-292606-tqjmg3qb 15 16 its -PRON- PRP$ cord-292606-tqjmg3qb 15 17 ability ability NN cord-292606-tqjmg3qb 15 18 to to TO cord-292606-tqjmg3qb 15 19 slow slow VB cord-292606-tqjmg3qb 15 20 down down RP cord-292606-tqjmg3qb 15 21 and and CC cord-292606-tqjmg3qb 15 22 arrest arrest VB cord-292606-tqjmg3qb 15 23 inflammatory inflammatory JJ cord-292606-tqjmg3qb 15 24 processes process NNS cord-292606-tqjmg3qb 15 25 . . . cord-292606-tqjmg3qb 16 1 Interleukin-10 Interleukin-10 NNP cord-292606-tqjmg3qb 16 2 ( ( -LRB- cord-292606-tqjmg3qb 16 3 IL-10 IL-10 NNP cord-292606-tqjmg3qb 16 4 ) ) -RRB- cord-292606-tqjmg3qb 16 5 and and CC cord-292606-tqjmg3qb 16 6 C1-esterase c1-esterase NN cord-292606-tqjmg3qb 16 7 inhibitors inhibitor NNS cord-292606-tqjmg3qb 16 8 ( ( -LRB- cord-292606-tqjmg3qb 16 9 C1-INH C1-INH NNP cord-292606-tqjmg3qb 16 10 ) ) -RRB- cord-292606-tqjmg3qb 16 11 are be VBP cord-292606-tqjmg3qb 16 12 two two CD cord-292606-tqjmg3qb 16 13 molecules molecule NNS cord-292606-tqjmg3qb 16 14 that that WDT cord-292606-tqjmg3qb 16 15 help help VBP cord-292606-tqjmg3qb 16 16 contain contain VB cord-292606-tqjmg3qb 16 17 and and CC cord-292606-tqjmg3qb 16 18 slow slow VB cord-292606-tqjmg3qb 16 19 down down RP cord-292606-tqjmg3qb 16 20 inflammatory inflammatory JJ cord-292606-tqjmg3qb 16 21 processes process NNS cord-292606-tqjmg3qb 16 22 , , , cord-292606-tqjmg3qb 16 23 while while IN cord-292606-tqjmg3qb 16 24 Interlukin-6 Interlukin-6 NNP cord-292606-tqjmg3qb 16 25 ( ( -LRB- cord-292606-tqjmg3qb 16 26 IL-6 IL-6 NNP cord-292606-tqjmg3qb 16 27 ) ) -RRB- cord-292606-tqjmg3qb 16 28 promotes promote VBZ cord-292606-tqjmg3qb 16 29 and and CC cord-292606-tqjmg3qb 16 30 intensifies intensify VBZ cord-292606-tqjmg3qb 16 31 inflammation inflammation NN cord-292606-tqjmg3qb 16 32 ( ( -LRB- cord-292606-tqjmg3qb 16 33 though though IN cord-292606-tqjmg3qb 16 34 it -PRON- PRP cord-292606-tqjmg3qb 16 35 has have VBZ cord-292606-tqjmg3qb 16 36 also also RB cord-292606-tqjmg3qb 16 37 some some DT cord-292606-tqjmg3qb 16 38 anti anti JJ cord-292606-tqjmg3qb 16 39 - - JJ cord-292606-tqjmg3qb 16 40 inflammatory inflammatory JJ cord-292606-tqjmg3qb 16 41 properties property NNS cord-292606-tqjmg3qb 16 42 in in IN cord-292606-tqjmg3qb 16 43 muscle muscle NN cord-292606-tqjmg3qb 16 44 cells cell NNS cord-292606-tqjmg3qb 16 45 ) ) -RRB- cord-292606-tqjmg3qb 16 46 . . . cord-292606-tqjmg3qb 17 1 Given give VBN cord-292606-tqjmg3qb 17 2 the the DT cord-292606-tqjmg3qb 17 3 up up JJ cord-292606-tqjmg3qb 17 4 - - HYPH cord-292606-tqjmg3qb 17 5 regulation regulation NN cord-292606-tqjmg3qb 17 6 of of IN cord-292606-tqjmg3qb 17 7 inflammatory inflammatory JJ cord-292606-tqjmg3qb 17 8 processes process NNS cord-292606-tqjmg3qb 17 9 with with IN cord-292606-tqjmg3qb 17 10 aging age VBG cord-292606-tqjmg3qb 17 11 , , , cord-292606-tqjmg3qb 17 12 it -PRON- PRP cord-292606-tqjmg3qb 17 13 is be VBZ cord-292606-tqjmg3qb 17 14 not not RB cord-292606-tqjmg3qb 17 15 surprising surprising JJ cord-292606-tqjmg3qb 17 16 that that IN cord-292606-tqjmg3qb 17 17 ARDS ARDS NNP cord-292606-tqjmg3qb 17 18 is be VBZ cord-292606-tqjmg3qb 17 19 usually usually RB cord-292606-tqjmg3qb 17 20 more more RBR cord-292606-tqjmg3qb 17 21 severe severe JJ cord-292606-tqjmg3qb 17 22 and and CC cord-292606-tqjmg3qb 17 23 more more RBR cord-292606-tqjmg3qb 17 24 lethal lethal JJ cord-292606-tqjmg3qb 17 25 in in IN cord-292606-tqjmg3qb 17 26 the the DT cord-292606-tqjmg3qb 17 27 elderly elderly JJ cord-292606-tqjmg3qb 17 28 resulting result VBG cord-292606-tqjmg3qb 17 29 in in IN cord-292606-tqjmg3qb 17 30 death death NN cord-292606-tqjmg3qb 17 31 rates rate NNS cord-292606-tqjmg3qb 17 32 over over IN cord-292606-tqjmg3qb 17 33 50 50 CD cord-292606-tqjmg3qb 17 34 % % NN cord-292606-tqjmg3qb 17 35 in in IN cord-292606-tqjmg3qb 17 36 the the DT cord-292606-tqjmg3qb 17 37 current current JJ cord-292606-tqjmg3qb 17 38 epidemic epidemic NN cord-292606-tqjmg3qb 17 39 . . . cord-292606-tqjmg3qb 18 1 But but CC cord-292606-tqjmg3qb 18 2 this this DT cord-292606-tqjmg3qb 18 3 " " `` cord-292606-tqjmg3qb 18 4 Cytokine cytokine NN cord-292606-tqjmg3qb 18 5 storm storm NN cord-292606-tqjmg3qb 18 6 " " '' cord-292606-tqjmg3qb 18 7 is be VBZ cord-292606-tqjmg3qb 18 8 not not RB cord-292606-tqjmg3qb 18 9 limited limit VBN cord-292606-tqjmg3qb 18 10 to to IN cord-292606-tqjmg3qb 18 11 the the DT cord-292606-tqjmg3qb 18 12 lungs lung NNS cord-292606-tqjmg3qb 18 13 , , , cord-292606-tqjmg3qb 18 14 and and CC cord-292606-tqjmg3qb 18 15 also also RB cord-292606-tqjmg3qb 18 16 involves involve VBZ cord-292606-tqjmg3qb 18 17 the the DT cord-292606-tqjmg3qb 18 18 kidneys kidney NNS cord-292606-tqjmg3qb 18 19 , , , cord-292606-tqjmg3qb 18 20 causing cause VBG cord-292606-tqjmg3qb 18 21 renal renal JJ cord-292606-tqjmg3qb 18 22 insufficiency insufficiency NN cord-292606-tqjmg3qb 18 23 and and CC cord-292606-tqjmg3qb 18 24 failure failure NN cord-292606-tqjmg3qb 18 25 , , , cord-292606-tqjmg3qb 18 26 and and CC cord-292606-tqjmg3qb 18 27 the the DT cord-292606-tqjmg3qb 18 28 vascular vascular JJ cord-292606-tqjmg3qb 18 29 system system NN cord-292606-tqjmg3qb 18 30 , , , cord-292606-tqjmg3qb 18 31 causing cause VBG cord-292606-tqjmg3qb 18 32 a a DT cord-292606-tqjmg3qb 18 33 vasculitis vasculitis NN cord-292606-tqjmg3qb 18 34 which which WDT cord-292606-tqjmg3qb 18 35 is be VBZ cord-292606-tqjmg3qb 18 36 at at IN cord-292606-tqjmg3qb 18 37 first first JJ cord-292606-tqjmg3qb 18 38 visible visible JJ cord-292606-tqjmg3qb 18 39 in in IN cord-292606-tqjmg3qb 18 40 the the DT cord-292606-tqjmg3qb 18 41 toes toe NNS cord-292606-tqjmg3qb 18 42 and and CC cord-292606-tqjmg3qb 18 43 is be VBZ cord-292606-tqjmg3qb 18 44 now now RB cord-292606-tqjmg3qb 18 45 known know VBN cord-292606-tqjmg3qb 18 46 as as IN cord-292606-tqjmg3qb 18 47 " " `` cord-292606-tqjmg3qb 18 48 Coronavirus Coronavirus NNP cord-292606-tqjmg3qb 18 49 toes toe NNS cord-292606-tqjmg3qb 18 50 . . . cord-292606-tqjmg3qb 19 1 " " `` cord-292606-tqjmg3qb 19 2 The the DT cord-292606-tqjmg3qb 19 3 " " `` cord-292606-tqjmg3qb 19 4 cytokine cytokine NN cord-292606-tqjmg3qb 19 5 storm storm NN cord-292606-tqjmg3qb 19 6 " " '' cord-292606-tqjmg3qb 19 7 does do VBZ cord-292606-tqjmg3qb 19 8 not not RB cord-292606-tqjmg3qb 19 9 spare spare VB cord-292606-tqjmg3qb 19 10 the the DT cord-292606-tqjmg3qb 19 11 Central Central NNP cord-292606-tqjmg3qb 19 12 Nervous Nervous NNP cord-292606-tqjmg3qb 19 13 System System NNP cord-292606-tqjmg3qb 19 14 ( ( -LRB- cord-292606-tqjmg3qb 19 15 CNS CNS NNP cord-292606-tqjmg3qb 19 16 ) ) -RRB- cord-292606-tqjmg3qb 19 17 either either CC cord-292606-tqjmg3qb 19 18 , , , cord-292606-tqjmg3qb 19 19 resulting result VBG cord-292606-tqjmg3qb 19 20 in in IN cord-292606-tqjmg3qb 19 21 headaches headache NNS cord-292606-tqjmg3qb 19 22 , , , cord-292606-tqjmg3qb 19 23 altered alter VBN cord-292606-tqjmg3qb 19 24 mental mental JJ cord-292606-tqjmg3qb 19 25 status status NN cord-292606-tqjmg3qb 19 26 , , , cord-292606-tqjmg3qb 19 27 confusion confusion NN cord-292606-tqjmg3qb 19 28 or or CC cord-292606-tqjmg3qb 19 29 inability inability NN cord-292606-tqjmg3qb 19 30 to to TO cord-292606-tqjmg3qb 19 31 arouse arouse VB cord-292606-tqjmg3qb 19 32 and and CC cord-292606-tqjmg3qb 19 33 the the DT cord-292606-tqjmg3qb 19 34 loss loss NN cord-292606-tqjmg3qb 19 35 of of IN cord-292606-tqjmg3qb 19 36 the the DT cord-292606-tqjmg3qb 19 37 sense sense NN cord-292606-tqjmg3qb 19 38 of of IN cord-292606-tqjmg3qb 19 39 smell smell NN cord-292606-tqjmg3qb 19 40 , , , cord-292606-tqjmg3qb 19 41 which which WDT cord-292606-tqjmg3qb 19 42 is be VBZ cord-292606-tqjmg3qb 19 43 reportedly reportedly RB cord-292606-tqjmg3qb 19 44 one one CD cord-292606-tqjmg3qb 19 45 of of IN cord-292606-tqjmg3qb 19 46 the the DT cord-292606-tqjmg3qb 19 47 early early JJ cord-292606-tqjmg3qb 19 48 symptoms symptom NNS cord-292606-tqjmg3qb 19 49 of of IN cord-292606-tqjmg3qb 19 50 the the DT cord-292606-tqjmg3qb 19 51 disease disease NN cord-292606-tqjmg3qb 19 52 . . . cord-292606-tqjmg3qb 20 1 36 36 CD cord-292606-tqjmg3qb 20 2 % % NN cord-292606-tqjmg3qb 20 3 of of IN cord-292606-tqjmg3qb 20 4 patients patient NNS cord-292606-tqjmg3qb 20 5 experienced experience VBD cord-292606-tqjmg3qb 20 6 some some DT cord-292606-tqjmg3qb 20 7 type type NN cord-292606-tqjmg3qb 20 8 of of IN cord-292606-tqjmg3qb 20 9 neurological neurological JJ cord-292606-tqjmg3qb 20 10 symptom symptom NN cord-292606-tqjmg3qb 20 11 . . . cord-292606-tqjmg3qb 21 1 On on IN cord-292606-tqjmg3qb 21 2 the the DT cord-292606-tqjmg3qb 21 3 mild mild JJ cord-292606-tqjmg3qb 21 4 end end NN cord-292606-tqjmg3qb 21 5 of of IN cord-292606-tqjmg3qb 21 6 the the DT cord-292606-tqjmg3qb 21 7 spectrum spectrum NN cord-292606-tqjmg3qb 21 8 , , , cord-292606-tqjmg3qb 21 9 people people NNS cord-292606-tqjmg3qb 21 10 commonly commonly RB cord-292606-tqjmg3qb 21 11 experienced experience VBD cord-292606-tqjmg3qb 21 12 the the DT cord-292606-tqjmg3qb 21 13 loss loss NN cord-292606-tqjmg3qb 21 14 of of IN cord-292606-tqjmg3qb 21 15 taste taste NN cord-292606-tqjmg3qb 21 16 and and CC cord-292606-tqjmg3qb 21 17 smell smell NN cord-292606-tqjmg3qb 21 18 . . . cord-292606-tqjmg3qb 22 1 Headache headache NN cord-292606-tqjmg3qb 22 2 was be VBD cord-292606-tqjmg3qb 22 3 reported report VBN cord-292606-tqjmg3qb 22 4 in in IN cord-292606-tqjmg3qb 22 5 13 13 CD cord-292606-tqjmg3qb 22 6 % % NN cord-292606-tqjmg3qb 22 7 of of IN cord-292606-tqjmg3qb 22 8 the the DT cord-292606-tqjmg3qb 22 9 patients patient NNS cord-292606-tqjmg3qb 22 10 , , , cord-292606-tqjmg3qb 22 11 dizziness dizziness NN cord-292606-tqjmg3qb 22 12 was be VBD cord-292606-tqjmg3qb 22 13 observed observe VBN cord-292606-tqjmg3qb 22 14 in in IN cord-292606-tqjmg3qb 22 15 about about RB cord-292606-tqjmg3qb 22 16 17 17 CD cord-292606-tqjmg3qb 22 17 % % NN cord-292606-tqjmg3qb 22 18 , , , cord-292606-tqjmg3qb 22 19 and and CC cord-292606-tqjmg3qb 22 20 muscle muscle NN cord-292606-tqjmg3qb 22 21 inflammation inflammation NN cord-292606-tqjmg3qb 22 22 and and CC cord-292606-tqjmg3qb 22 23 nerve nerve NN cord-292606-tqjmg3qb 22 24 pain pain NN cord-292606-tqjmg3qb 22 25 occurred occur VBD cord-292606-tqjmg3qb 22 26 in in IN cord-292606-tqjmg3qb 22 27 about about RB cord-292606-tqjmg3qb 22 28 19 19 CD cord-292606-tqjmg3qb 22 29 % % NN cord-292606-tqjmg3qb 22 30 . . . cord-292606-tqjmg3qb 23 1 Autopsy autopsy JJ cord-292606-tqjmg3qb 23 2 reports report NNS cord-292606-tqjmg3qb 23 3 have have VBP cord-292606-tqjmg3qb 23 4 revealed reveal VBN cord-292606-tqjmg3qb 23 5 brain brain NN cord-292606-tqjmg3qb 23 6 tissue tissue NN cord-292606-tqjmg3qb 23 7 edema edema NN cord-292606-tqjmg3qb 23 8 and and CC cord-292606-tqjmg3qb 23 9 partial partial JJ cord-292606-tqjmg3qb 23 10 neuronal neuronal JJ cord-292606-tqjmg3qb 23 11 degeneration degeneration NN cord-292606-tqjmg3qb 23 12 in in IN cord-292606-tqjmg3qb 23 13 deceased deceased JJ cord-292606-tqjmg3qb 23 14 patients patient NNS cord-292606-tqjmg3qb 23 15 . . . cord-292606-tqjmg3qb 24 1 To to TO cord-292606-tqjmg3qb 24 2 effectively effectively RB cord-292606-tqjmg3qb 24 3 treat treat VB cord-292606-tqjmg3qb 24 4 the the DT cord-292606-tqjmg3qb 24 5 " " `` cord-292606-tqjmg3qb 24 6 Citokine Citokine NNP cord-292606-tqjmg3qb 24 7 Storm storm NN cord-292606-tqjmg3qb 24 8 " " '' cord-292606-tqjmg3qb 24 9 Tocilizumab Tocilizumab NNP cord-292606-tqjmg3qb 24 10 ( ( -LRB- cord-292606-tqjmg3qb 24 11 Actemra Actemra NNP cord-292606-tqjmg3qb 24 12 ) ) -RRB- cord-292606-tqjmg3qb 24 13 has have VBZ cord-292606-tqjmg3qb 24 14 been be VBN cord-292606-tqjmg3qb 24 15 used use VBN cord-292606-tqjmg3qb 24 16 to to TO cord-292606-tqjmg3qb 24 17 block block VB cord-292606-tqjmg3qb 24 18 the the DT cord-292606-tqjmg3qb 24 19 pro pro JJ cord-292606-tqjmg3qb 24 20 - - JJ cord-292606-tqjmg3qb 24 21 inflammatory inflammatory JJ cord-292606-tqjmg3qb 24 22 action action NN cord-292606-tqjmg3qb 24 23 of of IN cord-292606-tqjmg3qb 24 24 Il-6 Il-6 NNP cord-292606-tqjmg3qb 24 25 , , , cord-292606-tqjmg3qb 24 26 and and CC cord-292606-tqjmg3qb 24 27 seems seem VBZ cord-292606-tqjmg3qb 24 28 to to TO cord-292606-tqjmg3qb 24 29 have have VB cord-292606-tqjmg3qb 24 30 been be VBN cord-292606-tqjmg3qb 24 31 helpful helpful JJ cord-292606-tqjmg3qb 24 32 in in IN cord-292606-tqjmg3qb 24 33 anecdotal anecdotal JJ cord-292606-tqjmg3qb 24 34 cases case NNS cord-292606-tqjmg3qb 24 35 ( ( -LRB- cord-292606-tqjmg3qb 24 36 3 3 CD cord-292606-tqjmg3qb 24 37 patients patient NNS cord-292606-tqjmg3qb 24 38 treated treat VBN cord-292606-tqjmg3qb 24 39 in in IN cord-292606-tqjmg3qb 24 40 Italy Italy NNP cord-292606-tqjmg3qb 24 41 ) ) -RRB- cord-292606-tqjmg3qb 24 42 . . . cord-292606-tqjmg3qb 25 1 C1-esterase C1-esterase NNP cord-292606-tqjmg3qb 25 2 Inhibitor Inhibitor NNP cord-292606-tqjmg3qb 25 3 ( ( -LRB- cord-292606-tqjmg3qb 25 4 Berinert Berinert NNP cord-292606-tqjmg3qb 25 5 , , , cord-292606-tqjmg3qb 25 6 Cynrize Cynrize NNP cord-292606-tqjmg3qb 25 7 , , , cord-292606-tqjmg3qb 25 8 Ruconest Ruconest NNP cord-292606-tqjmg3qb 25 9 ) ) -RRB- cord-292606-tqjmg3qb 25 10 could could MD cord-292606-tqjmg3qb 25 11 also also RB cord-292606-tqjmg3qb 25 12 be be VB cord-292606-tqjmg3qb 25 13 tested test VBN cord-292606-tqjmg3qb 25 14 to to TO cord-292606-tqjmg3qb 25 15 see see VB cord-292606-tqjmg3qb 25 16 if if IN cord-292606-tqjmg3qb 25 17 it -PRON- PRP cord-292606-tqjmg3qb 25 18 is be VBZ cord-292606-tqjmg3qb 25 19 capable capable JJ cord-292606-tqjmg3qb 25 20 slow slow JJ cord-292606-tqjmg3qb 25 21 the the DT cord-292606-tqjmg3qb 25 22 inflammatory inflammatory JJ cord-292606-tqjmg3qb 25 23 response response NN cord-292606-tqjmg3qb 25 24 . . . cord-292606-tqjmg3qb 26 1 But but CC cord-292606-tqjmg3qb 26 2 these these DT cord-292606-tqjmg3qb 26 3 are be VBP cord-292606-tqjmg3qb 26 4 very very RB cord-292606-tqjmg3qb 26 5 expensive expensive JJ cord-292606-tqjmg3qb 26 6 medications medication NNS cord-292606-tqjmg3qb 26 7 and and CC cord-292606-tqjmg3qb 26 8 difficult difficult JJ cord-292606-tqjmg3qb 26 9 to to TO cord-292606-tqjmg3qb 26 10 produce produce VB cord-292606-tqjmg3qb 26 11 rapidly rapidly RB cord-292606-tqjmg3qb 26 12 in in IN cord-292606-tqjmg3qb 26 13 quantities quantity NNS cord-292606-tqjmg3qb 26 14 . . . cord-292606-tqjmg3qb 27 1 Using use VBG cord-292606-tqjmg3qb 27 2 them -PRON- PRP cord-292606-tqjmg3qb 27 3 to to TO cord-292606-tqjmg3qb 27 4 treat treat VB cord-292606-tqjmg3qb 27 5 tens ten NNS cord-292606-tqjmg3qb 27 6 of of IN cord-292606-tqjmg3qb 27 7 thousands thousand NNS cord-292606-tqjmg3qb 27 8 of of IN cord-292606-tqjmg3qb 27 9 patients patient NNS cord-292606-tqjmg3qb 27 10 may may MD cord-292606-tqjmg3qb 27 11 prove prove VB cord-292606-tqjmg3qb 27 12 impossible impossible JJ cord-292606-tqjmg3qb 27 13 because because IN cord-292606-tqjmg3qb 27 14 of of IN cord-292606-tqjmg3qb 27 15 cost cost NN cord-292606-tqjmg3qb 27 16 and and CC cord-292606-tqjmg3qb 27 17 logistics logistic NNS cord-292606-tqjmg3qb 27 18 . . . cord-292606-tqjmg3qb 28 1 IL IL NNP cord-292606-tqjmg3qb 28 2 -10 -10 NNP cord-292606-tqjmg3qb 28 3 is be VBZ cord-292606-tqjmg3qb 28 4 another another DT cord-292606-tqjmg3qb 28 5 anti anti JJ cord-292606-tqjmg3qb 28 6 - - JJ cord-292606-tqjmg3qb 28 7 inflammatory inflammatory JJ cord-292606-tqjmg3qb 28 8 molecule molecule NN cord-292606-tqjmg3qb 28 9 that that WDT cord-292606-tqjmg3qb 28 10 could could MD cord-292606-tqjmg3qb 28 11 be be VB cord-292606-tqjmg3qb 28 12 tested test VBN cord-292606-tqjmg3qb 28 13 and and CC cord-292606-tqjmg3qb 28 14 it -PRON- PRP cord-292606-tqjmg3qb 28 15 could could MD cord-292606-tqjmg3qb 28 16 be be VB cord-292606-tqjmg3qb 28 17 administered administer VBN cord-292606-tqjmg3qb 28 18 via via IN cord-292606-tqjmg3qb 28 19 a a DT cord-292606-tqjmg3qb 28 20 genetherapy genetherapy NN cord-292606-tqjmg3qb 28 21 approach approach NN cord-292606-tqjmg3qb 28 22 using use VBG cord-292606-tqjmg3qb 28 23 naked naked JJ cord-292606-tqjmg3qb 28 24 plasmid plasmid NN cord-292606-tqjmg3qb 28 25 DNA dna NN cord-292606-tqjmg3qb 28 26 vectors vector NNS cord-292606-tqjmg3qb 28 27 4 4 CD cord-292606-tqjmg3qb 28 28 engineered engineer VBN cord-292606-tqjmg3qb 28 29 to to TO cord-292606-tqjmg3qb 28 30 produce produce VB cord-292606-tqjmg3qb 28 31 IL-10 IL-10 NNP cord-292606-tqjmg3qb 28 32 inside inside IN cord-292606-tqjmg3qb 28 33 the the DT cord-292606-tqjmg3qb 28 34 recipient recipient NN cord-292606-tqjmg3qb 28 35 cells cell NNS cord-292606-tqjmg3qb 28 36 , , , cord-292606-tqjmg3qb 28 37 thus thus RB cord-292606-tqjmg3qb 28 38 reducing reduce VBG cord-292606-tqjmg3qb 28 39 the the DT cord-292606-tqjmg3qb 28 40 cost cost NN cord-292606-tqjmg3qb 28 41 and and CC cord-292606-tqjmg3qb 28 42 simplifying simplify VBG cord-292606-tqjmg3qb 28 43 production production NN cord-292606-tqjmg3qb 28 44 . . . cord-292606-tqjmg3qb 29 1 It -PRON- PRP cord-292606-tqjmg3qb 29 2 would would MD cord-292606-tqjmg3qb 29 3 be be VB cord-292606-tqjmg3qb 29 4 more more RBR cord-292606-tqjmg3qb 29 5 cost cost NN cord-292606-tqjmg3qb 29 6 - - HYPH cord-292606-tqjmg3qb 29 7 effective effective JJ cord-292606-tqjmg3qb 29 8 for for IN cord-292606-tqjmg3qb 29 9 treating treat VBG cord-292606-tqjmg3qb 29 10 many many JJ cord-292606-tqjmg3qb 29 11 thousands thousand NNS cord-292606-tqjmg3qb 29 12 of of IN cord-292606-tqjmg3qb 29 13 patients patient NNS cord-292606-tqjmg3qb 29 14 . . . cord-292606-tqjmg3qb 30 1 Covid-19 Covid-19 NNP cord-292606-tqjmg3qb 30 2 infection infection NN cord-292606-tqjmg3qb 30 3 involves involve VBZ cord-292606-tqjmg3qb 30 4 multiple multiple JJ cord-292606-tqjmg3qb 30 5 organs organ NNS cord-292606-tqjmg3qb 30 6 and and CC cord-292606-tqjmg3qb 30 7 systems system NNS cord-292606-tqjmg3qb 30 8 , , , cord-292606-tqjmg3qb 30 9 with with IN cord-292606-tqjmg3qb 30 10 symptoms symptom NNS cord-292606-tqjmg3qb 30 11 developing develop VBG cord-292606-tqjmg3qb 30 12 rapidly rapidly RB cord-292606-tqjmg3qb 30 13 over over IN cord-292606-tqjmg3qb 30 14 2 2 CD cord-292606-tqjmg3qb 30 15 - - SYM cord-292606-tqjmg3qb 30 16 14 14 CD cord-292606-tqjmg3qb 30 17 days day NNS cord-292606-tqjmg3qb 30 18 . . . cord-292606-tqjmg3qb 31 1 Most Most JJS cord-292606-tqjmg3qb 31 2 infections infection NNS cord-292606-tqjmg3qb 31 3 however however RB cord-292606-tqjmg3qb 31 4 produce produce VBP cord-292606-tqjmg3qb 31 5 mild mild JJ cord-292606-tqjmg3qb 31 6 or or CC cord-292606-tqjmg3qb 31 7 minimal minimal JJ cord-292606-tqjmg3qb 31 8 symptoms symptom NNS cord-292606-tqjmg3qb 31 9 and and CC cord-292606-tqjmg3qb 31 10 up up IN cord-292606-tqjmg3qb 31 11 to to TO cord-292606-tqjmg3qb 31 12 80 80 CD cord-292606-tqjmg3qb 31 13 % % NN cord-292606-tqjmg3qb 31 14 of of IN cord-292606-tqjmg3qb 31 15 persons person NNS cord-292606-tqjmg3qb 31 16 infected infect VBN cord-292606-tqjmg3qb 31 17 may may MD cord-292606-tqjmg3qb 31 18 have have VB cord-292606-tqjmg3qb 31 19 mild mild JJ cord-292606-tqjmg3qb 31 20 disease disease NN cord-292606-tqjmg3qb 31 21 or or CC cord-292606-tqjmg3qb 31 22 even even RB cord-292606-tqjmg3qb 31 23 be be VB cord-292606-tqjmg3qb 31 24 asymptomatic asymptomatic JJ cord-292606-tqjmg3qb 31 25 . . . cord-292606-tqjmg3qb 32 1 Reports report NNS cord-292606-tqjmg3qb 32 2 from from IN cord-292606-tqjmg3qb 32 3 Italy Italy NNP cord-292606-tqjmg3qb 32 4 indicate indicate VBP cord-292606-tqjmg3qb 32 5 that that IN cord-292606-tqjmg3qb 32 6 some some DT cord-292606-tqjmg3qb 32 7 individuals individual NNS cord-292606-tqjmg3qb 32 8 have have VBP cord-292606-tqjmg3qb 32 9 remained remain VBN cord-292606-tqjmg3qb 32 10 positive positive JJ cord-292606-tqjmg3qb 32 11 to to IN cord-292606-tqjmg3qb 32 12 nasal nasal VB cord-292606-tqjmg3qb 32 13 swabs swab NNS cord-292606-tqjmg3qb 32 14 for for IN cord-292606-tqjmg3qb 32 15 Covid-19 covid-19 NN cord-292606-tqjmg3qb 32 16 for for IN cord-292606-tqjmg3qb 32 17 at at RB cord-292606-tqjmg3qb 32 18 least least JJS cord-292606-tqjmg3qb 32 19 50 50 CD cord-292606-tqjmg3qb 32 20 days day NNS cord-292606-tqjmg3qb 32 21 since since IN cord-292606-tqjmg3qb 32 22 their -PRON- PRP$ cord-292606-tqjmg3qb 32 23 initial initial JJ cord-292606-tqjmg3qb 32 24 positive positive JJ cord-292606-tqjmg3qb 32 25 test test NN cord-292606-tqjmg3qb 32 26 , , , cord-292606-tqjmg3qb 32 27 and and CC cord-292606-tqjmg3qb 32 28 after after IN cord-292606-tqjmg3qb 32 29 having have VBG cord-292606-tqjmg3qb 32 30 apparently apparently RB cord-292606-tqjmg3qb 32 31 healed heal VBN cord-292606-tqjmg3qb 32 32 from from IN cord-292606-tqjmg3qb 32 33 the the DT cord-292606-tqjmg3qb 32 34 illness illness NN cord-292606-tqjmg3qb 32 35 . . . cord-292606-tqjmg3qb 33 1 There there EX cord-292606-tqjmg3qb 33 2 is be VBZ cord-292606-tqjmg3qb 33 3 one one CD cord-292606-tqjmg3qb 33 4 case case NN cord-292606-tqjmg3qb 33 5 of of IN cord-292606-tqjmg3qb 33 6 a a DT cord-292606-tqjmg3qb 33 7 person person NN cord-292606-tqjmg3qb 33 8 that that WDT cord-292606-tqjmg3qb 33 9 has have VBZ cord-292606-tqjmg3qb 33 10 had have VBN cord-292606-tqjmg3qb 33 11 positive positive JJ cord-292606-tqjmg3qb 33 12 nasal nasal NN cord-292606-tqjmg3qb 33 13 swabs swab NNS cord-292606-tqjmg3qb 33 14 for for IN cord-292606-tqjmg3qb 33 15 57 57 CD cord-292606-tqjmg3qb 33 16 days day NNS cord-292606-tqjmg3qb 33 17 . . . cord-292606-tqjmg3qb 34 1 This this DT cord-292606-tqjmg3qb 34 2 raises raise VBZ cord-292606-tqjmg3qb 34 3 the the DT cord-292606-tqjmg3qb 34 4 possibility possibility NN cord-292606-tqjmg3qb 34 5 that that IN cord-292606-tqjmg3qb 34 6 some some DT cord-292606-tqjmg3qb 34 7 individuals individual NNS cord-292606-tqjmg3qb 34 8 , , , cord-292606-tqjmg3qb 34 9 after after IN cord-292606-tqjmg3qb 34 10 recovering recover VBG cord-292606-tqjmg3qb 34 11 from from IN cord-292606-tqjmg3qb 34 12 their -PRON- PRP$ cord-292606-tqjmg3qb 34 13 illness illness NN cord-292606-tqjmg3qb 34 14 may may MD cord-292606-tqjmg3qb 34 15 become become VB cord-292606-tqjmg3qb 34 16 asymptomatic asymptomatic JJ cord-292606-tqjmg3qb 34 17 carriers carrier NNS cord-292606-tqjmg3qb 34 18 of of IN cord-292606-tqjmg3qb 34 19 the the DT cord-292606-tqjmg3qb 34 20 virus virus NN cord-292606-tqjmg3qb 34 21 for for IN cord-292606-tqjmg3qb 34 22 extended extended JJ cord-292606-tqjmg3qb 34 23 periods period NNS cord-292606-tqjmg3qb 34 24 of of IN cord-292606-tqjmg3qb 34 25 time time NN cord-292606-tqjmg3qb 34 26 , , , cord-292606-tqjmg3qb 34 27 further further RB cord-292606-tqjmg3qb 34 28 complicating complicate VBG cord-292606-tqjmg3qb 34 29 efforts effort NNS cord-292606-tqjmg3qb 34 30 at at IN cord-292606-tqjmg3qb 34 31 containing contain VBG cord-292606-tqjmg3qb 34 32 the the DT cord-292606-tqjmg3qb 34 33 pandemic pandemic NN cord-292606-tqjmg3qb 34 34 and and CC cord-292606-tqjmg3qb 34 35 requiring require VBG cord-292606-tqjmg3qb 34 36 that that IN cord-292606-tqjmg3qb 34 37 patients patient NNS cord-292606-tqjmg3qb 34 38 be be VB cord-292606-tqjmg3qb 34 39 tested test VBN cord-292606-tqjmg3qb 34 40 after after IN cord-292606-tqjmg3qb 34 41 their -PRON- PRP$ cord-292606-tqjmg3qb 34 42 recovery recovery NN cord-292606-tqjmg3qb 34 43 to to TO cord-292606-tqjmg3qb 34 44 make make VB cord-292606-tqjmg3qb 34 45 sure sure JJ cord-292606-tqjmg3qb 34 46 they -PRON- PRP cord-292606-tqjmg3qb 34 47 clear clear VBP cord-292606-tqjmg3qb 34 48 the the DT cord-292606-tqjmg3qb 34 49 virus virus NN cord-292606-tqjmg3qb 34 50 . . . cord-292606-tqjmg3qb 35 1 This this DT cord-292606-tqjmg3qb 35 2 means mean VBZ cord-292606-tqjmg3qb 35 3 that that IN cord-292606-tqjmg3qb 35 4 antivirals antiviral NNS cord-292606-tqjmg3qb 35 5 and and CC cord-292606-tqjmg3qb 35 6 vaccines vaccine NNS cord-292606-tqjmg3qb 35 7 will will MD cord-292606-tqjmg3qb 35 8 be be VB cord-292606-tqjmg3qb 35 9 needed need VBN cord-292606-tqjmg3qb 35 10 . . . cord-292606-tqjmg3qb 36 1 Countries country NNS cord-292606-tqjmg3qb 36 2 need need VBP cord-292606-tqjmg3qb 36 3 to to TO cord-292606-tqjmg3qb 36 4 invest invest VB cord-292606-tqjmg3qb 36 5 in in IN cord-292606-tqjmg3qb 36 6 technologies technology NNS cord-292606-tqjmg3qb 36 7 like like IN cord-292606-tqjmg3qb 36 8 DNA dna NN cord-292606-tqjmg3qb 36 9 vaccines vaccine NNS cord-292606-tqjmg3qb 36 10 5 5 CD cord-292606-tqjmg3qb 36 11 and and CC cord-292606-tqjmg3qb 36 12 antiviral antiviral JJ cord-292606-tqjmg3qb 36 13 gene gene NN cord-292606-tqjmg3qb 36 14 therapy therapy NN cord-292606-tqjmg3qb 36 15 strategies strategy NNS cord-292606-tqjmg3qb 36 16 , , , cord-292606-tqjmg3qb 36 17 like like IN cord-292606-tqjmg3qb 36 18 RNAi RNAi NNP cord-292606-tqjmg3qb 36 19 technology technology NNP cord-292606-tqjmg3qb 36 20 , , , cord-292606-tqjmg3qb 36 21 which which WDT cord-292606-tqjmg3qb 36 22 is be VBZ cord-292606-tqjmg3qb 36 23 an an DT cord-292606-tqjmg3qb 36 24 ideal ideal JJ cord-292606-tqjmg3qb 36 25 tool tool NN cord-292606-tqjmg3qb 36 26 for for IN cord-292606-tqjmg3qb 36 27 inhibiting inhibit VBG cord-292606-tqjmg3qb 36 28 viral viral JJ cord-292606-tqjmg3qb 36 29 replication replication NN cord-292606-tqjmg3qb 36 30 in in IN cord-292606-tqjmg3qb 36 31 host host NN cord-292606-tqjmg3qb 36 32 cells cell NNS cord-292606-tqjmg3qb 36 33 as as IN cord-292606-tqjmg3qb 36 34 the the DT cord-292606-tqjmg3qb 36 35 siRNA siRNA NNP cord-292606-tqjmg3qb 36 36 can can MD cord-292606-tqjmg3qb 36 37 interact interact VB cord-292606-tqjmg3qb 36 38 with with IN cord-292606-tqjmg3qb 36 39 certain certain JJ cord-292606-tqjmg3qb 36 40 viral viral JJ cord-292606-tqjmg3qb 36 41 genes gene NNS cord-292606-tqjmg3qb 36 42 and and CC cord-292606-tqjmg3qb 36 43 silence silence VB cord-292606-tqjmg3qb 36 44 their -PRON- PRP$ cord-292606-tqjmg3qb 36 45 expression expression NN cord-292606-tqjmg3qb 36 46 . . . cord-292606-tqjmg3qb 37 1 6 6 CD cord-292606-tqjmg3qb 37 2 DNA dna NN cord-292606-tqjmg3qb 37 3 based base VBN cord-292606-tqjmg3qb 37 4 therapeutics therapeutic NNS cord-292606-tqjmg3qb 37 5 can can MD cord-292606-tqjmg3qb 37 6 be be VB cord-292606-tqjmg3qb 37 7 developed develop VBN cord-292606-tqjmg3qb 37 8 immediately immediately RB cord-292606-tqjmg3qb 37 9 after after IN cord-292606-tqjmg3qb 37 10 a a DT cord-292606-tqjmg3qb 37 11 virus virus NN cord-292606-tqjmg3qb 37 12 DNA dna NN cord-292606-tqjmg3qb 37 13 sequence sequence NN cord-292606-tqjmg3qb 37 14 becomes become VBZ cord-292606-tqjmg3qb 37 15 known know VBN cord-292606-tqjmg3qb 37 16 . . . cord-292606-tqjmg3qb 38 1 Modular modular JJ cord-292606-tqjmg3qb 38 2 plasmid plasmid NN cord-292606-tqjmg3qb 38 3 vectors vector NNS cord-292606-tqjmg3qb 38 4 could could MD cord-292606-tqjmg3qb 38 5 be be VB cord-292606-tqjmg3qb 38 6 created create VBN cord-292606-tqjmg3qb 38 7 that that WDT cord-292606-tqjmg3qb 38 8 allow allow VB cord-292606-tqjmg3qb 38 9 to to TO cord-292606-tqjmg3qb 38 10 switch switch VB cord-292606-tqjmg3qb 38 11 one one CD cord-292606-tqjmg3qb 38 12 viral viral JJ cord-292606-tqjmg3qb 38 13 sequence sequence NN cord-292606-tqjmg3qb 38 14 for for IN cord-292606-tqjmg3qb 38 15 another another DT cord-292606-tqjmg3qb 38 16 and and CC cord-292606-tqjmg3qb 38 17 produce produce VB cord-292606-tqjmg3qb 38 18 a a DT cord-292606-tqjmg3qb 38 19 new new JJ cord-292606-tqjmg3qb 38 20 vaccine vaccine NN cord-292606-tqjmg3qb 38 21 with with IN cord-292606-tqjmg3qb 38 22 minimal minimal JJ cord-292606-tqjmg3qb 38 23 manipulation manipulation NN cord-292606-tqjmg3qb 38 24 . . . cord-292606-tqjmg3qb 39 1 The the DT cord-292606-tqjmg3qb 39 2 same same JJ cord-292606-tqjmg3qb 39 3 applies apply VBZ cord-292606-tqjmg3qb 39 4 to to IN cord-292606-tqjmg3qb 39 5 RNAi RNAi NNP cord-292606-tqjmg3qb 39 6 vectors vector NNS cord-292606-tqjmg3qb 39 7 . . . cord-292606-tqjmg3qb 40 1 These these DT cord-292606-tqjmg3qb 40 2 strategies strategy NNS cord-292606-tqjmg3qb 40 3 are be VBP cord-292606-tqjmg3qb 40 4 also also RB cord-292606-tqjmg3qb 40 5 likely likely JJ cord-292606-tqjmg3qb 40 6 to to TO cord-292606-tqjmg3qb 40 7 be be VB cord-292606-tqjmg3qb 40 8 much much RB cord-292606-tqjmg3qb 40 9 more more JJR cord-292606-tqjmg3qb 40 10 costefficient costefficient JJ cord-292606-tqjmg3qb 40 11 than than IN cord-292606-tqjmg3qb 40 12 other other JJ cord-292606-tqjmg3qb 40 13 methods method NNS cord-292606-tqjmg3qb 40 14 , , , cord-292606-tqjmg3qb 40 15 a a DT cord-292606-tqjmg3qb 40 16 consideration consideration NN cord-292606-tqjmg3qb 40 17 that that WDT cord-292606-tqjmg3qb 40 18 becomes become VBZ cord-292606-tqjmg3qb 40 19 important important JJ cord-292606-tqjmg3qb 40 20 as as IN cord-292606-tqjmg3qb 40 21 the the DT cord-292606-tqjmg3qb 40 22 population population NN cord-292606-tqjmg3qb 40 23 needing need VBG cord-292606-tqjmg3qb 40 24 treatment treatment NN cord-292606-tqjmg3qb 40 25 expands expand VBZ cord-292606-tqjmg3qb 40 26 . . . cord-292606-tqjmg3qb 41 1 We -PRON- PRP cord-292606-tqjmg3qb 41 2 need need VBP cord-292606-tqjmg3qb 41 3 to to TO cord-292606-tqjmg3qb 41 4 develop develop VB cord-292606-tqjmg3qb 41 5 detailed detailed JJ cord-292606-tqjmg3qb 41 6 protocols protocol NNS cord-292606-tqjmg3qb 41 7 now now RB cord-292606-tqjmg3qb 41 8 on on IN cord-292606-tqjmg3qb 41 9 how how WRB cord-292606-tqjmg3qb 41 10 to to TO cord-292606-tqjmg3qb 41 11 quickly quickly RB cord-292606-tqjmg3qb 41 12 produce produce VB cord-292606-tqjmg3qb 41 13 vaccines vaccine NNS cord-292606-tqjmg3qb 41 14 and and CC cord-292606-tqjmg3qb 41 15 antivirals antiviral NNS cord-292606-tqjmg3qb 41 16 , , , cord-292606-tqjmg3qb 41 17 that that WDT cord-292606-tqjmg3qb 41 18 can can MD cord-292606-tqjmg3qb 41 19 be be VB cord-292606-tqjmg3qb 41 20 adapted adapt VBN cord-292606-tqjmg3qb 41 21 to to IN cord-292606-tqjmg3qb 41 22 future future JJ cord-292606-tqjmg3qb 41 23 viral viral JJ cord-292606-tqjmg3qb 41 24 pandemics pandemic NNS cord-292606-tqjmg3qb 41 25 . . . cord-292606-tqjmg3qb 42 1 We -PRON- PRP cord-292606-tqjmg3qb 42 2 also also RB cord-292606-tqjmg3qb 42 3 need need VBP cord-292606-tqjmg3qb 42 4 to to TO cord-292606-tqjmg3qb 42 5 develop develop VB cord-292606-tqjmg3qb 42 6 protocols protocol NNS cord-292606-tqjmg3qb 42 7 for for IN cord-292606-tqjmg3qb 42 8 the the DT cord-292606-tqjmg3qb 42 9 most most RBS cord-292606-tqjmg3qb 42 10 effective effective JJ cord-292606-tqjmg3qb 42 11 containment containment NN cord-292606-tqjmg3qb 42 12 and and CC cord-292606-tqjmg3qb 42 13 mitigation mitigation NN cord-292606-tqjmg3qb 42 14 strategies strategy NNS cord-292606-tqjmg3qb 42 15 , , , cord-292606-tqjmg3qb 42 16 so so IN cord-292606-tqjmg3qb 42 17 they -PRON- PRP cord-292606-tqjmg3qb 42 18 can can MD cord-292606-tqjmg3qb 42 19 be be VB cord-292606-tqjmg3qb 42 20 implemented implement VBN cord-292606-tqjmg3qb 42 21 without without IN cord-292606-tqjmg3qb 42 22 hesitation hesitation NN cord-292606-tqjmg3qb 42 23 in in IN cord-292606-tqjmg3qb 42 24 future future JJ cord-292606-tqjmg3qb 42 25 emergencies emergency NNS cord-292606-tqjmg3qb 42 26 . . . cord-292606-tqjmg3qb 43 1 Alessandro Alessandro NNP cord-292606-tqjmg3qb 43 2 Testori Testori NNP cord-292606-tqjmg3qb 43 3 , , , cord-292606-tqjmg3qb 43 4 MD MD NNP cord-292606-tqjmg3qb 43 5 Immunoe Immunoe NNP cord-292606-tqjmg3qb 43 6 Health Health NNP cord-292606-tqjmg3qb 43 7 Research Research NNP cord-292606-tqjmg3qb 43 8 Centers Centers NNPS cord-292606-tqjmg3qb 43 9 Longmont Longmont NNP cord-292606-tqjmg3qb 43 10 , , , cord-292606-tqjmg3qb 43 11 Colorado Colorado NNP cord-292606-tqjmg3qb 43 12 Treatment Treatment NNP cord-292606-tqjmg3qb 43 13 considerations consideration NNS cord-292606-tqjmg3qb 43 14 for for IN cord-292606-tqjmg3qb 43 15 COVID-19 covid-19 CD cord-292606-tqjmg3qb 43 16 : : : cord-292606-tqjmg3qb 43 17 A a DT cord-292606-tqjmg3qb 43 18 critical critical JJ cord-292606-tqjmg3qb 43 19 review review NN cord-292606-tqjmg3qb 43 20 of of IN cord-292606-tqjmg3qb 43 21 the the DT cord-292606-tqjmg3qb 43 22 evidence evidence NN cord-292606-tqjmg3qb 43 23 ( ( -LRB- cord-292606-tqjmg3qb 43 24 or or CC cord-292606-tqjmg3qb 43 25 lack lack NN cord-292606-tqjmg3qb 43 26 thereof thereof RB cord-292606-tqjmg3qb 43 27 ) ) -RRB- cord-292606-tqjmg3qb 44 1 The the DT cord-292606-tqjmg3qb 44 2 acute acute JJ cord-292606-tqjmg3qb 44 3 respiratory respiratory JJ cord-292606-tqjmg3qb 44 4 distress distress NN cord-292606-tqjmg3qb 44 5 syndrome syndrome NN cord-292606-tqjmg3qb 44 6 Inflammatory inflammatory JJ cord-292606-tqjmg3qb 44 7 networks network NNS cord-292606-tqjmg3qb 44 8 in in IN cord-292606-tqjmg3qb 44 9 ageing ageing NN cord-292606-tqjmg3qb 44 10 , , , cord-292606-tqjmg3qb 44 11 age age NN cord-292606-tqjmg3qb 44 12 - - HYPH cord-292606-tqjmg3qb 44 13 related relate VBN cord-292606-tqjmg3qb 44 14 diseases disease NNS cord-292606-tqjmg3qb 44 15 and and CC cord-292606-tqjmg3qb 44 16 longevity longevity NN cord-292606-tqjmg3qb 44 17 Progress progress NN cord-292606-tqjmg3qb 44 18 and and CC cord-292606-tqjmg3qb 44 19 prospects prospect NNS cord-292606-tqjmg3qb 44 20 : : : cord-292606-tqjmg3qb 44 21 naked naked JJ cord-292606-tqjmg3qb 44 22 DNA DNA NNP cord-292606-tqjmg3qb 44 23 Gene Gene NNP cord-292606-tqjmg3qb 44 24 transfer transfer NN cord-292606-tqjmg3qb 44 25 and and CC cord-292606-tqjmg3qb 44 26 therapy therapy NN cord-292606-tqjmg3qb 44 27 Generation generation NN cord-292606-tqjmg3qb 44 28 and and CC cord-292606-tqjmg3qb 44 29 characterization characterization NN cord-292606-tqjmg3qb 44 30 of of IN cord-292606-tqjmg3qb 44 31 DNA dna NN cord-292606-tqjmg3qb 44 32 vaccines vaccine NNS cord-292606-tqjmg3qb 44 33 targeting target VBG cord-292606-tqjmg3qb 44 34 the the DT cord-292606-tqjmg3qb 44 35 nucleocapsid nucleocapsid NNP cord-292606-tqjmg3qb 44 36 protein protein NN cord-292606-tqjmg3qb 44 37 of of IN cord-292606-tqjmg3qb 44 38 Severe severe JJ cord-292606-tqjmg3qb 44 39 Acute acute JJ cord-292606-tqjmg3qb 44 40 Respiratory Respiratory NNP cord-292606-tqjmg3qb 44 41 Syndrome Syndrome NNP cord-292606-tqjmg3qb 44 42 Coronavirus Coronavirus NNP cord-292606-tqjmg3qb 44 43 Inhibition Inhibition NNP cord-292606-tqjmg3qb 44 44 of of IN cord-292606-tqjmg3qb 44 45 SARS SARS NNP cord-292606-tqjmg3qb 44 46 - - HYPH cord-292606-tqjmg3qb 44 47 CoV CoV NNP cord-292606-tqjmg3qb 44 48 replication replication NN cord-292606-tqjmg3qb 44 49 by by IN cord-292606-tqjmg3qb 44 50 siRNA siRNA NNP