id sid tid token lemma pos cord-260402-9b1ltcf1 1 1 key key NN cord-260402-9b1ltcf1 1 2 : : : cord-260402-9b1ltcf1 2 1 cord-260402 cord-260402 NNP cord-260402-9b1ltcf1 2 2 - - HYPH cord-260402-9b1ltcf1 2 3 9b1ltcf1 9b1ltcf1 CD cord-260402-9b1ltcf1 2 4 authors author NNS cord-260402-9b1ltcf1 2 5 : : : cord-260402-9b1ltcf1 2 6 Lang Lang NNP cord-260402-9b1ltcf1 2 7 , , , cord-260402-9b1ltcf1 2 8 Adam Adam NNP cord-260402-9b1ltcf1 2 9 Edward Edward NNP cord-260402-9b1ltcf1 2 10 ; ; : cord-260402-9b1ltcf1 2 11 Yakhkind Yakhkind NNP cord-260402-9b1ltcf1 2 12 , , , cord-260402-9b1ltcf1 2 13 Aleksandra Aleksandra NNP cord-260402-9b1ltcf1 2 14 title title NN cord-260402-9b1ltcf1 2 15 : : : cord-260402-9b1ltcf1 3 1 More More JJR cord-260402-9b1ltcf1 3 2 Than than IN cord-260402-9b1ltcf1 3 3 Meets meet VBZ cord-260402-9b1ltcf1 3 4 the the DT cord-260402-9b1ltcf1 3 5 Eye Eye NNP cord-260402-9b1ltcf1 3 6 : : : cord-260402-9b1ltcf1 3 7 The the DT cord-260402-9b1ltcf1 3 8 Similarities Similarities NNPS cord-260402-9b1ltcf1 3 9 Between between IN cord-260402-9b1ltcf1 3 10 COVID-19 COVID-19 NNP cord-260402-9b1ltcf1 3 11 and and CC cord-260402-9b1ltcf1 3 12 Smoking Smoking NNP cord-260402-9b1ltcf1 3 13 date date NN cord-260402-9b1ltcf1 3 14 : : : cord-260402-9b1ltcf1 3 15 2020 2020 CD cord-260402-9b1ltcf1 3 16 - - HYPH cord-260402-9b1ltcf1 3 17 08 08 CD cord-260402-9b1ltcf1 3 18 - - HYPH cord-260402-9b1ltcf1 3 19 11 11 CD cord-260402-9b1ltcf1 3 20 journal journal NN cord-260402-9b1ltcf1 3 21 : : : cord-260402-9b1ltcf1 3 22 Mayo Mayo NNP cord-260402-9b1ltcf1 3 23 Clin Clin NNP cord-260402-9b1ltcf1 3 24 Proc Proc NNP cord-260402-9b1ltcf1 3 25 DOI doi NN cord-260402-9b1ltcf1 3 26 : : : cord-260402-9b1ltcf1 3 27 10.1016 10.1016 CD cord-260402-9b1ltcf1 3 28 / / SYM cord-260402-9b1ltcf1 3 29 j.mayocp.2020.08.008 j.mayocp.2020.08.008 CD cord-260402-9b1ltcf1 3 30 sha sha NNP cord-260402-9b1ltcf1 3 31 : : : cord-260402-9b1ltcf1 4 1 753378b1ad3008eec7879f48b1cd6113d336201c 753378b1ad3008eec7879f48b1cd6113d336201c NNP cord-260402-9b1ltcf1 4 2 doc_id doc_id CD cord-260402-9b1ltcf1 4 3 : : : cord-260402-9b1ltcf1 4 4 260402 260402 CD cord-260402-9b1ltcf1 4 5 cord_uid cord_uid NNS cord-260402-9b1ltcf1 4 6 : : : cord-260402-9b1ltcf1 4 7 9b1ltcf1 9b1ltcf1 CD cord-260402-9b1ltcf1 4 8 nan nan NNP cord-260402-9b1ltcf1 5 1 To to IN cord-260402-9b1ltcf1 5 2 the the DT cord-260402-9b1ltcf1 5 3 Editor Editor NNP cord-260402-9b1ltcf1 5 4 : : : cord-260402-9b1ltcf1 5 5 Research research NN cord-260402-9b1ltcf1 5 6 shows show VBZ cord-260402-9b1ltcf1 5 7 that that IN cord-260402-9b1ltcf1 5 8 cigarette cigarette NN cord-260402-9b1ltcf1 5 9 smoking smoking NN cord-260402-9b1ltcf1 5 10 upregulates upregulate VBZ cord-260402-9b1ltcf1 5 11 ACE2 ACE2 NNP cord-260402-9b1ltcf1 5 12 , , , cord-260402-9b1ltcf1 5 13 the the DT cord-260402-9b1ltcf1 5 14 receptor receptor NN cord-260402-9b1ltcf1 5 15 by by IN cord-260402-9b1ltcf1 5 16 which which WDT cord-260402-9b1ltcf1 5 17 SARS SARS NNP cord-260402-9b1ltcf1 5 18 - - HYPH cord-260402-9b1ltcf1 5 19 CoV-2 CoV-2 NNP cord-260402-9b1ltcf1 5 20 gains gain VBZ cord-260402-9b1ltcf1 5 21 entry entry NN cord-260402-9b1ltcf1 5 22 to to IN cord-260402-9b1ltcf1 5 23 the the DT cord-260402-9b1ltcf1 5 24 host host NN cord-260402-9b1ltcf1 5 25 resulting result VBG cord-260402-9b1ltcf1 5 26 in in IN cord-260402-9b1ltcf1 5 27 COVID-19 COVID-19 NNP cord-260402-9b1ltcf1 5 28 , , , cord-260402-9b1ltcf1 5 29 in in IN cord-260402-9b1ltcf1 5 30 the the DT cord-260402-9b1ltcf1 5 31 lungs lung NNS cord-260402-9b1ltcf1 5 32 and and CC cord-260402-9b1ltcf1 5 33 therefore therefore RB cord-260402-9b1ltcf1 5 34 potentially potentially RB cord-260402-9b1ltcf1 5 35 leads lead VBZ cord-260402-9b1ltcf1 5 36 to to IN cord-260402-9b1ltcf1 5 37 increased increase VBN cord-260402-9b1ltcf1 5 38 morbidity morbidity NN cord-260402-9b1ltcf1 5 39 [ [ -LRB- cord-260402-9b1ltcf1 5 40 1 1 CD cord-260402-9b1ltcf1 5 41 ] ] -RRB- cord-260402-9b1ltcf1 5 42 . . . cord-260402-9b1ltcf1 6 1 However however RB cord-260402-9b1ltcf1 6 2 , , , cord-260402-9b1ltcf1 6 3 the the DT cord-260402-9b1ltcf1 6 4 virus virus NN cord-260402-9b1ltcf1 6 5 and and CC cord-260402-9b1ltcf1 6 6 smoking smoking NN cord-260402-9b1ltcf1 6 7 share share VBP cord-260402-9b1ltcf1 6 8 far far RB cord-260402-9b1ltcf1 6 9 more more JJR cord-260402-9b1ltcf1 6 10 similarities similarity NNS cord-260402-9b1ltcf1 6 11 than than IN cord-260402-9b1ltcf1 6 12 meet meet VB cord-260402-9b1ltcf1 6 13 the the DT cord-260402-9b1ltcf1 6 14 eye eye NN cord-260402-9b1ltcf1 6 15 . . . cord-260402-9b1ltcf1 7 1 As as IN cord-260402-9b1ltcf1 7 2 part part NN cord-260402-9b1ltcf1 7 3 of of IN cord-260402-9b1ltcf1 7 4 a a DT cord-260402-9b1ltcf1 7 5 tobacco tobacco NN cord-260402-9b1ltcf1 7 6 treatment treatment NN cord-260402-9b1ltcf1 7 7 campaign campaign NN cord-260402-9b1ltcf1 7 8 implemented implement VBN cord-260402-9b1ltcf1 7 9 at at IN cord-260402-9b1ltcf1 7 10 the the DT cord-260402-9b1ltcf1 7 11 beginning beginning NN cord-260402-9b1ltcf1 7 12 of of IN cord-260402-9b1ltcf1 7 13 the the DT cord-260402-9b1ltcf1 7 14 pandemic pandemic NN cord-260402-9b1ltcf1 7 15 at at IN cord-260402-9b1ltcf1 7 16 McDonald McDonald NNP cord-260402-9b1ltcf1 7 17 Army Army NNP cord-260402-9b1ltcf1 7 18 Health Health NNP cord-260402-9b1ltcf1 7 19 Center Center NNP cord-260402-9b1ltcf1 7 20 , , , cord-260402-9b1ltcf1 7 21 the the DT cord-260402-9b1ltcf1 7 22 authors author NNS cord-260402-9b1ltcf1 7 23 performed perform VBD cord-260402-9b1ltcf1 7 24 a a DT cord-260402-9b1ltcf1 7 25 literature literature NN cord-260402-9b1ltcf1 7 26 search search NN cord-260402-9b1ltcf1 7 27 and and CC cord-260402-9b1ltcf1 7 28 found find VBD cord-260402-9b1ltcf1 7 29 that that IN cord-260402-9b1ltcf1 7 30 SARS SARS NNP cord-260402-9b1ltcf1 7 31 - - HYPH cord-260402-9b1ltcf1 7 32 CoV-2 CoV-2 NNP cord-260402-9b1ltcf1 7 33 and and CC cord-260402-9b1ltcf1 7 34 smoking smoking NN cord-260402-9b1ltcf1 7 35 both both DT cord-260402-9b1ltcf1 7 36 contribute contribute VBP cord-260402-9b1ltcf1 7 37 to to IN cord-260402-9b1ltcf1 7 38 myocarditis myocarditis NN cord-260402-9b1ltcf1 7 39 , , , cord-260402-9b1ltcf1 7 40 thrombosis thrombosis NN cord-260402-9b1ltcf1 7 41 , , , cord-260402-9b1ltcf1 7 42 immune immune JJ cord-260402-9b1ltcf1 7 43 impairment impairment NN cord-260402-9b1ltcf1 7 44 , , , cord-260402-9b1ltcf1 7 45 and and CC cord-260402-9b1ltcf1 7 46 increased increase VBN cord-260402-9b1ltcf1 7 47 inflammation inflammation NN cord-260402-9b1ltcf1 7 48 . . . cord-260402-9b1ltcf1 8 1 SARS SARS NNP cord-260402-9b1ltcf1 8 2 - - HYPH cord-260402-9b1ltcf1 8 3 CoV-2 CoV-2 NNP cord-260402-9b1ltcf1 8 4 leads lead VBZ cord-260402-9b1ltcf1 8 5 to to IN cord-260402-9b1ltcf1 8 6 an an DT cord-260402-9b1ltcf1 8 7 increase increase NN cord-260402-9b1ltcf1 8 8 NF nf NN cord-260402-9b1ltcf1 8 9 - - HYPH cord-260402-9b1ltcf1 8 10 κB κB NNP cord-260402-9b1ltcf1 8 11 , , , cord-260402-9b1ltcf1 8 12 TNF tnf NN cord-260402-9b1ltcf1 8 13 - - HYPH cord-260402-9b1ltcf1 8 14 alpha alpha NN cord-260402-9b1ltcf1 8 15 , , , cord-260402-9b1ltcf1 8 16 and and CC cord-260402-9b1ltcf1 8 17 lymphocyte lymphocyte NN cord-260402-9b1ltcf1 8 18 dysregulation dysregulation NN cord-260402-9b1ltcf1 8 19 . . . cord-260402-9b1ltcf1 9 1 Smoking smoking NN cord-260402-9b1ltcf1 9 2 leads lead VBZ cord-260402-9b1ltcf1 9 3 to to IN cord-260402-9b1ltcf1 9 4 an an DT cord-260402-9b1ltcf1 9 5 increase increase NN cord-260402-9b1ltcf1 9 6 of of IN cord-260402-9b1ltcf1 9 7 neutrophil neutrophil NN cord-260402-9b1ltcf1 9 8 counts count NNS cord-260402-9b1ltcf1 9 9 and and CC cord-260402-9b1ltcf1 9 10 can can MD cord-260402-9b1ltcf1 9 11 cause cause VB cord-260402-9b1ltcf1 9 12 neutrophil neutrophil NN cord-260402-9b1ltcf1 9 13 - - HYPH cord-260402-9b1ltcf1 9 14 to to IN cord-260402-9b1ltcf1 9 15 - - HYPH cord-260402-9b1ltcf1 9 16 lymphocyte lymphocyte NN cord-260402-9b1ltcf1 9 17 ratio ratio NN cord-260402-9b1ltcf1 9 18 elevation elevation NN cord-260402-9b1ltcf1 9 19 . . . cord-260402-9b1ltcf1 10 1 Together together RB cord-260402-9b1ltcf1 10 2 , , , cord-260402-9b1ltcf1 10 3 this this DT cord-260402-9b1ltcf1 10 4 can can MD cord-260402-9b1ltcf1 10 5 contribute contribute VB cord-260402-9b1ltcf1 10 6 to to IN cord-260402-9b1ltcf1 10 7 the the DT cord-260402-9b1ltcf1 10 8 development development NN cord-260402-9b1ltcf1 10 9 of of IN cord-260402-9b1ltcf1 10 10 and and CC cord-260402-9b1ltcf1 10 11 worse bad JJR cord-260402-9b1ltcf1 10 12 outcomes outcome NNS cord-260402-9b1ltcf1 10 13 in in IN cord-260402-9b1ltcf1 10 14 patients patient NNS cord-260402-9b1ltcf1 10 15 with with IN cord-260402-9b1ltcf1 10 16 ARDS ARDS NNP cord-260402-9b1ltcf1 10 17 [ [ -LRB- cord-260402-9b1ltcf1 10 18 2 2 CD cord-260402-9b1ltcf1 10 19 ] ] -RRB- cord-260402-9b1ltcf1 10 20 . . . cord-260402-9b1ltcf1 11 1 Fibrin fibrin NN cord-260402-9b1ltcf1 11 2 deposition deposition NN cord-260402-9b1ltcf1 11 3 in in IN cord-260402-9b1ltcf1 11 4 pulmonary pulmonary JJ cord-260402-9b1ltcf1 11 5 vasculature vasculature NN cord-260402-9b1ltcf1 11 6 , , , cord-260402-9b1ltcf1 11 7 which which WDT cord-260402-9b1ltcf1 11 8 is be VBZ cord-260402-9b1ltcf1 11 9 increased increase VBN cord-260402-9b1ltcf1 11 10 in in IN cord-260402-9b1ltcf1 11 11 both both DT cord-260402-9b1ltcf1 11 12 COVID-19 covid-19 NN cord-260402-9b1ltcf1 11 13 and and CC cord-260402-9b1ltcf1 11 14 smoking smoking NN cord-260402-9b1ltcf1 11 15 , , , cord-260402-9b1ltcf1 11 16 is be VBZ cord-260402-9b1ltcf1 11 17 thought think VBN cord-260402-9b1ltcf1 11 18 to to TO cord-260402-9b1ltcf1 11 19 contribute contribute VB cord-260402-9b1ltcf1 11 20 to to IN cord-260402-9b1ltcf1 11 21 the the DT cord-260402-9b1ltcf1 11 22 development development NN cord-260402-9b1ltcf1 11 23 of of IN cord-260402-9b1ltcf1 11 24 ARDS ARDS NNP cord-260402-9b1ltcf1 11 25 . . . cord-260402-9b1ltcf1 12 1 Tissue tissue NN cord-260402-9b1ltcf1 12 2 Factor factor NN cord-260402-9b1ltcf1 12 3 ( ( -LRB- cord-260402-9b1ltcf1 12 4 TF TF NNP cord-260402-9b1ltcf1 12 5 ) ) -RRB- cord-260402-9b1ltcf1 12 6 , , , cord-260402-9b1ltcf1 12 7 which which WDT cord-260402-9b1ltcf1 12 8 initiates initiate VBZ cord-260402-9b1ltcf1 12 9 the the DT cord-260402-9b1ltcf1 12 10 extrinsic extrinsic JJ cord-260402-9b1ltcf1 12 11 coagulation coagulation NN cord-260402-9b1ltcf1 12 12 cascade cascade NN cord-260402-9b1ltcf1 12 13 , , , cord-260402-9b1ltcf1 12 14 is be VBZ cord-260402-9b1ltcf1 12 15 expressed express VBN cord-260402-9b1ltcf1 12 16 highly highly RB cord-260402-9b1ltcf1 12 17 by by IN cord-260402-9b1ltcf1 12 18 alveolar alveolar JJ cord-260402-9b1ltcf1 12 19 macrophages macrophage NNS cord-260402-9b1ltcf1 12 20 and and CC cord-260402-9b1ltcf1 12 21 epithelial epithelial JJ cord-260402-9b1ltcf1 12 22 cells cell NNS cord-260402-9b1ltcf1 12 23 . . . cord-260402-9b1ltcf1 13 1 Inflammatory inflammatory JJ cord-260402-9b1ltcf1 13 2 cytokines cytokine NNS cord-260402-9b1ltcf1 13 3 and and CC cord-260402-9b1ltcf1 13 4 regulators regulator NNS cord-260402-9b1ltcf1 13 5 including include VBG cord-260402-9b1ltcf1 13 6 TNF TNF NNP cord-260402-9b1ltcf1 13 7 - - HYPH cord-260402-9b1ltcf1 13 8 α α NNP cord-260402-9b1ltcf1 13 9 and and CC cord-260402-9b1ltcf1 13 10 NF nf NN cord-260402-9b1ltcf1 13 11 - - HYPH cord-260402-9b1ltcf1 13 12 κB κB NNP cord-260402-9b1ltcf1 13 13 upregulate upregulate VBD cord-260402-9b1ltcf1 13 14 TF TF NNP cord-260402-9b1ltcf1 13 15 expression expression NN cord-260402-9b1ltcf1 13 16 , , , cord-260402-9b1ltcf1 13 17 leading lead VBG cord-260402-9b1ltcf1 13 18 to to IN cord-260402-9b1ltcf1 13 19 fibrin fibrin NN cord-260402-9b1ltcf1 13 20 deposition deposition NN cord-260402-9b1ltcf1 13 21 , , , cord-260402-9b1ltcf1 13 22 further further JJ cord-260402-9b1ltcf1 13 23 inflammation inflammation NN cord-260402-9b1ltcf1 13 24 and and CC cord-260402-9b1ltcf1 13 25 microvascular microvascular JJ cord-260402-9b1ltcf1 13 26 permeability permeability NN cord-260402-9b1ltcf1 13 27 in in IN cord-260402-9b1ltcf1 13 28 the the DT cord-260402-9b1ltcf1 13 29 lungs lung NNS cord-260402-9b1ltcf1 13 30 [ [ -LRB- cord-260402-9b1ltcf1 13 31 3 3 CD cord-260402-9b1ltcf1 13 32 ] ] -RRB- cord-260402-9b1ltcf1 13 33 . . . cord-260402-9b1ltcf1 14 1 SARS SARS NNP cord-260402-9b1ltcf1 14 2 - - HYPH cord-260402-9b1ltcf1 14 3 CoV-2 CoV-2 NNP cord-260402-9b1ltcf1 14 4 and and CC cord-260402-9b1ltcf1 14 5 smoking smoking NN cord-260402-9b1ltcf1 14 6 upregulate upregulate VB cord-260402-9b1ltcf1 14 7 this this DT cord-260402-9b1ltcf1 14 8 cytokine cytokine NN cord-260402-9b1ltcf1 14 9 release release NN cord-260402-9b1ltcf1 14 10 and and CC cord-260402-9b1ltcf1 14 11 lead lead VB cord-260402-9b1ltcf1 14 12 to to IN cord-260402-9b1ltcf1 14 13 an an DT cord-260402-9b1ltcf1 14 14 increased increase VBN cord-260402-9b1ltcf1 14 15 risk risk NN cord-260402-9b1ltcf1 14 16 of of IN cord-260402-9b1ltcf1 14 17 coagulopathy coagulopathy NN cord-260402-9b1ltcf1 14 18 [ [ -LRB- cord-260402-9b1ltcf1 14 19 4 4 CD cord-260402-9b1ltcf1 14 20 , , , cord-260402-9b1ltcf1 14 21 5 5 CD cord-260402-9b1ltcf1 14 22 ] ] -RRB- cord-260402-9b1ltcf1 14 23 . . . cord-260402-9b1ltcf1 15 1 The the DT cord-260402-9b1ltcf1 15 2 upregulation upregulation NN cord-260402-9b1ltcf1 15 3 of of IN cord-260402-9b1ltcf1 15 4 ACE2 ACE2 NNP cord-260402-9b1ltcf1 15 5 in in IN cord-260402-9b1ltcf1 15 6 smokers smoker NNS cord-260402-9b1ltcf1 15 7 may may MD cord-260402-9b1ltcf1 15 8 predispose predispose VB cord-260402-9b1ltcf1 15 9 this this DT cord-260402-9b1ltcf1 15 10 population population NN cord-260402-9b1ltcf1 15 11 to to IN cord-260402-9b1ltcf1 15 12 an an DT cord-260402-9b1ltcf1 15 13 increased increase VBN cord-260402-9b1ltcf1 15 14 risk risk NN cord-260402-9b1ltcf1 15 15 of of IN cord-260402-9b1ltcf1 15 16 SARS SARS NNP cord-260402-9b1ltcf1 15 17 - - HYPH cord-260402-9b1ltcf1 15 18 CoV-2 CoV-2 NNP cord-260402-9b1ltcf1 15 19 infection infection NN cord-260402-9b1ltcf1 15 20 . . . cord-260402-9b1ltcf1 16 1 The the DT cord-260402-9b1ltcf1 16 2 host host NN cord-260402-9b1ltcf1 16 3 cell cell NN cord-260402-9b1ltcf1 16 4 transmembrane transmembrane NN cord-260402-9b1ltcf1 16 5 protease protease NN cord-260402-9b1ltcf1 16 6 , , , cord-260402-9b1ltcf1 16 7 serine serine NN cord-260402-9b1ltcf1 16 8 2 2 CD cord-260402-9b1ltcf1 16 9 ( ( -LRB- cord-260402-9b1ltcf1 16 10 TMPSRSS2 TMPSRSS2 NNP cord-260402-9b1ltcf1 16 11 ) ) -RRB- cord-260402-9b1ltcf1 16 12 , , , cord-260402-9b1ltcf1 16 13 which which WDT cord-260402-9b1ltcf1 16 14 primes prime VBZ cord-260402-9b1ltcf1 16 15 the the DT cord-260402-9b1ltcf1 16 16 SAR SAR NNP cord-260402-9b1ltcf1 16 17 - - HYPH cord-260402-9b1ltcf1 16 18 CoV-2 CoV-2 NNP cord-260402-9b1ltcf1 16 19 S S NNP cord-260402-9b1ltcf1 16 20 protein protein NN cord-260402-9b1ltcf1 16 21 for for IN cord-260402-9b1ltcf1 16 22 entry entry NN cord-260402-9b1ltcf1 16 23 , , , cord-260402-9b1ltcf1 16 24 may may MD cord-260402-9b1ltcf1 16 25 also also RB cord-260402-9b1ltcf1 16 26 be be VB cord-260402-9b1ltcf1 16 27 upregulated upregulate VBN cord-260402-9b1ltcf1 16 28 in in IN cord-260402-9b1ltcf1 16 29 smokers smoker NNS cord-260402-9b1ltcf1 16 30 [ [ -LRB- cord-260402-9b1ltcf1 16 31 6 6 CD cord-260402-9b1ltcf1 16 32 ] ] -RRB- cord-260402-9b1ltcf1 16 33 , , , cord-260402-9b1ltcf1 16 34 which which WDT cord-260402-9b1ltcf1 16 35 would would MD cord-260402-9b1ltcf1 16 36 further further RB cord-260402-9b1ltcf1 16 37 increase increase VB cord-260402-9b1ltcf1 16 38 the the DT cord-260402-9b1ltcf1 16 39 odds odd NNS cord-260402-9b1ltcf1 16 40 of of IN cord-260402-9b1ltcf1 16 41 viral viral JJ cord-260402-9b1ltcf1 16 42 infectivity infectivity NN cord-260402-9b1ltcf1 16 43 . . . cord-260402-9b1ltcf1 17 1 From from IN cord-260402-9b1ltcf1 17 2 a a DT cord-260402-9b1ltcf1 17 3 cardiovascular cardiovascular JJ cord-260402-9b1ltcf1 17 4 perspective perspective NN cord-260402-9b1ltcf1 17 5 , , , cord-260402-9b1ltcf1 17 6 NT NT NNP cord-260402-9b1ltcf1 17 7 - - HYPH cord-260402-9b1ltcf1 17 8 proBNP proBNP NNP cord-260402-9b1ltcf1 17 9 , , , cord-260402-9b1ltcf1 17 10 LDH LDH NNP cord-260402-9b1ltcf1 17 11 and and CC cord-260402-9b1ltcf1 17 12 ferritin ferritin NN cord-260402-9b1ltcf1 17 13 have have VBP cord-260402-9b1ltcf1 17 14 been be VBN cord-260402-9b1ltcf1 17 15 shown show VBN cord-260402-9b1ltcf1 17 16 to to TO cord-260402-9b1ltcf1 17 17 be be VB cord-260402-9b1ltcf1 17 18 predictors predictor NNS cord-260402-9b1ltcf1 17 19 of of IN cord-260402-9b1ltcf1 17 20 poor poor JJ cord-260402-9b1ltcf1 17 21 outcomes outcome NNS cord-260402-9b1ltcf1 17 22 and and CC cord-260402-9b1ltcf1 17 23 cardiac cardiac JJ cord-260402-9b1ltcf1 17 24 tissue tissue NN cord-260402-9b1ltcf1 17 25 damage damage NN cord-260402-9b1ltcf1 17 26 in in IN cord-260402-9b1ltcf1 17 27 those those DT cord-260402-9b1ltcf1 17 28 with with IN cord-260402-9b1ltcf1 17 29 COVID-19 COVID-19 NNP cord-260402-9b1ltcf1 17 30 [ [ -LRB- cord-260402-9b1ltcf1 17 31 7 7 CD cord-260402-9b1ltcf1 17 32 ] ] -RRB- cord-260402-9b1ltcf1 17 33 . . . cord-260402-9b1ltcf1 18 1 Smoking smoking NN cord-260402-9b1ltcf1 18 2 has have VBZ cord-260402-9b1ltcf1 18 3 been be VBN cord-260402-9b1ltcf1 18 4 shown show VBN cord-260402-9b1ltcf1 18 5 to to TO cord-260402-9b1ltcf1 18 6 cause cause VB cord-260402-9b1ltcf1 18 7 elevations elevation NNS cord-260402-9b1ltcf1 18 8 in in IN cord-260402-9b1ltcf1 18 9 all all DT cord-260402-9b1ltcf1 18 10 of of IN cord-260402-9b1ltcf1 18 11 these these DT cord-260402-9b1ltcf1 18 12 parameters parameter NNS cord-260402-9b1ltcf1 18 13 , , , cord-260402-9b1ltcf1 18 14 potentially potentially RB cord-260402-9b1ltcf1 18 15 contributing contribute VBG cord-260402-9b1ltcf1 18 16 to to IN cord-260402-9b1ltcf1 18 17 the the DT cord-260402-9b1ltcf1 18 18 detrimental detrimental JJ cord-260402-9b1ltcf1 18 19 impact impact NN cord-260402-9b1ltcf1 18 20 of of IN cord-260402-9b1ltcf1 18 21 SARS SARS NNP cord-260402-9b1ltcf1 18 22 - - HYPH cord-260402-9b1ltcf1 18 23 CoV-2 CoV-2 NNP cord-260402-9b1ltcf1 18 24 on on IN cord-260402-9b1ltcf1 18 25 the the DT cord-260402-9b1ltcf1 18 26 myocardium myocardium NN cord-260402-9b1ltcf1 18 27 [ [ -LRB- cord-260402-9b1ltcf1 18 28 8 8 CD cord-260402-9b1ltcf1 18 29 ] ] -RRB- cord-260402-9b1ltcf1 18 30 [ [ -LRB- cord-260402-9b1ltcf1 18 31 9 9 CD cord-260402-9b1ltcf1 18 32 ] ] -RRB- cord-260402-9b1ltcf1 18 33 [ [ -LRB- cord-260402-9b1ltcf1 18 34 10 10 CD cord-260402-9b1ltcf1 18 35 ] ] -RRB- cord-260402-9b1ltcf1 18 36 . . . cord-260402-9b1ltcf1 19 1 While while IN cord-260402-9b1ltcf1 19 2 the the DT cord-260402-9b1ltcf1 19 3 lungs lung NNS cord-260402-9b1ltcf1 19 4 are be VBP cord-260402-9b1ltcf1 19 5 a a DT cord-260402-9b1ltcf1 19 6 gateway gateway NN cord-260402-9b1ltcf1 19 7 to to IN cord-260402-9b1ltcf1 19 8 the the DT cord-260402-9b1ltcf1 19 9 body body NN cord-260402-9b1ltcf1 19 10 for for IN cord-260402-9b1ltcf1 19 11 both both DT cord-260402-9b1ltcf1 19 12 tobacco tobacco NN cord-260402-9b1ltcf1 19 13 smoke smoke NN cord-260402-9b1ltcf1 19 14 and and CC cord-260402-9b1ltcf1 19 15 SARS SARS NNP cord-260402-9b1ltcf1 19 16 - - HYPH cord-260402-9b1ltcf1 19 17 CoV-2 CoV-2 NNP cord-260402-9b1ltcf1 19 18 , , , cord-260402-9b1ltcf1 19 19 they -PRON- PRP cord-260402-9b1ltcf1 19 20 each each DT cord-260402-9b1ltcf1 19 21 exhibit exhibit VBP cord-260402-9b1ltcf1 19 22 harmful harmful JJ cord-260402-9b1ltcf1 19 23 systemic systemic JJ cord-260402-9b1ltcf1 19 24 effects effect NNS cord-260402-9b1ltcf1 19 25 throughout throughout IN cord-260402-9b1ltcf1 19 26 the the DT cord-260402-9b1ltcf1 19 27 body body NN cord-260402-9b1ltcf1 19 28 . . . cord-260402-9b1ltcf1 20 1 Our -PRON- PRP$ cord-260402-9b1ltcf1 20 2 goal goal NN cord-260402-9b1ltcf1 20 3 is be VBZ cord-260402-9b1ltcf1 20 4 to to TO cord-260402-9b1ltcf1 20 5 bring bring VB cord-260402-9b1ltcf1 20 6 awareness awareness NN cord-260402-9b1ltcf1 20 7 to to IN cord-260402-9b1ltcf1 20 8 the the DT cord-260402-9b1ltcf1 20 9 similar similar JJ cord-260402-9b1ltcf1 20 10 and and CC cord-260402-9b1ltcf1 20 11 potentially potentially RB cord-260402-9b1ltcf1 20 12 synergistic synergistic JJ cord-260402-9b1ltcf1 20 13 ways way NNS cord-260402-9b1ltcf1 20 14 in in IN cord-260402-9b1ltcf1 20 15 which which WDT cord-260402-9b1ltcf1 20 16 smoking smoking NN cord-260402-9b1ltcf1 20 17 and and CC cord-260402-9b1ltcf1 20 18 SARS SARS NNP cord-260402-9b1ltcf1 20 19 - - HYPH cord-260402-9b1ltcf1 20 20 CoV-2 CoV-2 NNP cord-260402-9b1ltcf1 20 21 cause cause VB cord-260402-9b1ltcf1 20 22 harm harm NN cord-260402-9b1ltcf1 20 23 in in IN cord-260402-9b1ltcf1 20 24 order order NN cord-260402-9b1ltcf1 20 25 to to TO cord-260402-9b1ltcf1 20 26 guide guide VB cord-260402-9b1ltcf1 20 27 research research NN cord-260402-9b1ltcf1 20 28 and and CC cord-260402-9b1ltcf1 20 29 work work NN cord-260402-9b1ltcf1 20 30 towards towards IN cord-260402-9b1ltcf1 20 31 a a DT cord-260402-9b1ltcf1 20 32 better well JJR cord-260402-9b1ltcf1 20 33 understanding understanding NN cord-260402-9b1ltcf1 20 34 of of IN cord-260402-9b1ltcf1 20 35 both both DT cord-260402-9b1ltcf1 20 36 conditions condition NNS cord-260402-9b1ltcf1 20 37 . . . cord-260402-9b1ltcf1 20 38 _SP cord-260402-9b1ltcf1 21 1 ACE-2 ACE-2 NNP cord-260402-9b1ltcf1 21 2 expression expression NN cord-260402-9b1ltcf1 21 3 in in IN cord-260402-9b1ltcf1 21 4 the the DT cord-260402-9b1ltcf1 21 5 small small JJ cord-260402-9b1ltcf1 21 6 airway airway NN cord-260402-9b1ltcf1 21 7 epithelia epithelium NNS cord-260402-9b1ltcf1 21 8 of of IN cord-260402-9b1ltcf1 21 9 smokers smoker NNS cord-260402-9b1ltcf1 21 10 and and CC cord-260402-9b1ltcf1 21 11 COPD COPD NNP cord-260402-9b1ltcf1 21 12 patients patient NNS cord-260402-9b1ltcf1 21 13 : : : cord-260402-9b1ltcf1 21 14 implications implication NNS cord-260402-9b1ltcf1 21 15 for for IN cord-260402-9b1ltcf1 21 16 COVID-19 COVID-19 NNP cord-260402-9b1ltcf1 21 17 COVID-19 COVID-19 NNP cord-260402-9b1ltcf1 21 18 and and CC cord-260402-9b1ltcf1 21 19 Smoking smoking NN cord-260402-9b1ltcf1 21 20 : : : cord-260402-9b1ltcf1 22 1 How how WRB cord-260402-9b1ltcf1 22 2 and and CC cord-260402-9b1ltcf1 22 3 Why why WRB cord-260402-9b1ltcf1 22 4 We -PRON- PRP cord-260402-9b1ltcf1 22 5 Implemented implement VBD cord-260402-9b1ltcf1 22 6 a a DT cord-260402-9b1ltcf1 22 7 Tobacco Tobacco NNP cord-260402-9b1ltcf1 22 8 Treatment Treatment NNP cord-260402-9b1ltcf1 22 9 Campaign Campaign NNP cord-260402-9b1ltcf1 22 10 Therapeutic therapeutic JJ cord-260402-9b1ltcf1 22 11 modulation modulation NN cord-260402-9b1ltcf1 22 12 of of IN cord-260402-9b1ltcf1 22 13 coagulation coagulation NN cord-260402-9b1ltcf1 22 14 and and CC cord-260402-9b1ltcf1 22 15 fibrinolysis fibrinolysis NN cord-260402-9b1ltcf1 22 16 in in IN cord-260402-9b1ltcf1 22 17 acute acute JJ cord-260402-9b1ltcf1 22 18 lung lung NN cord-260402-9b1ltcf1 22 19 injury injury NN cord-260402-9b1ltcf1 22 20 and and CC cord-260402-9b1ltcf1 22 21 the the DT cord-260402-9b1ltcf1 22 22 acute acute JJ cord-260402-9b1ltcf1 22 23 respiratory respiratory JJ cord-260402-9b1ltcf1 22 24 distress distress NN cord-260402-9b1ltcf1 22 25 syndrome syndrome NN cord-260402-9b1ltcf1 23 1 ISTH isth JJ cord-260402-9b1ltcf1 23 2 interim interim JJ cord-260402-9b1ltcf1 23 3 guidance guidance NN cord-260402-9b1ltcf1 23 4 on on IN cord-260402-9b1ltcf1 23 5 recognition recognition NN cord-260402-9b1ltcf1 23 6 and and CC cord-260402-9b1ltcf1 23 7 management management NN cord-260402-9b1ltcf1 23 8 of of IN cord-260402-9b1ltcf1 23 9 coagulopathy coagulopathy NN cord-260402-9b1ltcf1 23 10 in in IN cord-260402-9b1ltcf1 23 11 COVID-19 COVID-19 NNP cord-260402-9b1ltcf1 23 12 Acute acute JJ cord-260402-9b1ltcf1 23 13 effects effect NNS cord-260402-9b1ltcf1 23 14 of of IN cord-260402-9b1ltcf1 23 15 cigarette cigarette NN cord-260402-9b1ltcf1 23 16 smoking smoking NN cord-260402-9b1ltcf1 23 17 on on IN cord-260402-9b1ltcf1 23 18 platelet platelet NN cord-260402-9b1ltcf1 23 19 - - HYPH cord-260402-9b1ltcf1 23 20 dependent dependent JJ cord-260402-9b1ltcf1 23 21 thrombin thrombin NN cord-260402-9b1ltcf1 23 22 generation generation NN cord-260402-9b1ltcf1 23 23 Smoking smoking NN cord-260402-9b1ltcf1 23 24 - - HYPH cord-260402-9b1ltcf1 23 25 Mediated mediate VBN cord-260402-9b1ltcf1 23 26 Upregulation Upregulation NNP cord-260402-9b1ltcf1 23 27 of of IN cord-260402-9b1ltcf1 23 28 the the DT cord-260402-9b1ltcf1 23 29 Androgen Androgen NNP cord-260402-9b1ltcf1 23 30 Pathway Pathway NNP cord-260402-9b1ltcf1 23 31 Leads lead VBZ cord-260402-9b1ltcf1 23 32 to to IN cord-260402-9b1ltcf1 23 33 Increased increase VBN cord-260402-9b1ltcf1 23 34 SARS SARS NNP cord-260402-9b1ltcf1 23 35 - - HYPH cord-260402-9b1ltcf1 23 36 CoV-2 CoV-2 NNP cord-260402-9b1ltcf1 23 37 Susceptibility susceptibility NN cord-260402-9b1ltcf1 23 38 Mild mild JJ cord-260402-9b1ltcf1 23 39 versus versus IN cord-260402-9b1ltcf1 23 40 severe severe JJ cord-260402-9b1ltcf1 23 41 COVID-19 covid-19 NN cord-260402-9b1ltcf1 23 42 : : : cord-260402-9b1ltcf1 23 43 Laboratory Laboratory NNP cord-260402-9b1ltcf1 23 44 Markers Markers NNPS cord-260402-9b1ltcf1 23 45 Serum Serum NNP cord-260402-9b1ltcf1 23 46 and and CC cord-260402-9b1ltcf1 23 47 Salivary Salivary NNP cord-260402-9b1ltcf1 23 48 Lactate Lactate NNP cord-260402-9b1ltcf1 23 49 Dehydryogenase Dehydryogenase NNP cord-260402-9b1ltcf1 23 50 Levels Levels NNP cord-260402-9b1ltcf1 23 51 as as IN cord-260402-9b1ltcf1 23 52 Biomarkers Biomarkers NNPS cord-260402-9b1ltcf1 23 53 of of IN cord-260402-9b1ltcf1 23 54 Tissue tissue NN cord-260402-9b1ltcf1 23 55 Damage damage NN cord-260402-9b1ltcf1 24 1 Among among IN cord-260402-9b1ltcf1 24 2 Cigarette Cigarette NNP cord-260402-9b1ltcf1 24 3 Smokers Smokers NNPS cord-260402-9b1ltcf1 24 4 Association Association NNP cord-260402-9b1ltcf1 24 5 of of IN cord-260402-9b1ltcf1 24 6 serum serum NN cord-260402-9b1ltcf1 24 7 ferritin ferritin NN cord-260402-9b1ltcf1 24 8 levels level NNS cord-260402-9b1ltcf1 24 9 with with IN cord-260402-9b1ltcf1 24 10 smoking smoking NN cord-260402-9b1ltcf1 24 11 and and CC cord-260402-9b1ltcf1 24 12 lung lung NN cord-260402-9b1ltcf1 24 13 function function NN cord-260402-9b1ltcf1 24 14 in in IN cord-260402-9b1ltcf1 24 15 the the DT cord-260402-9b1ltcf1 24 16 Korean korean JJ cord-260402-9b1ltcf1 24 17 adult adult NN cord-260402-9b1ltcf1 24 18 population population NN cord-260402-9b1ltcf1 24 19 : : : cord-260402-9b1ltcf1 24 20 analysis analysis NN cord-260402-9b1ltcf1 24 21 of of IN cord-260402-9b1ltcf1 24 22 the the DT cord-260402-9b1ltcf1 24 23 fourth fourth JJ cord-260402-9b1ltcf1 24 24 and and CC cord-260402-9b1ltcf1 24 25 fifth fifth JJ cord-260402-9b1ltcf1 24 26 Korean Korean NNP cord-260402-9b1ltcf1 24 27 National National NNP cord-260402-9b1ltcf1 24 28 Health Health NNP cord-260402-9b1ltcf1 24 29 and and CC cord-260402-9b1ltcf1 24 30 Nutrition Nutrition NNP cord-260402-9b1ltcf1 24 31 Examination Examination NNP cord-260402-9b1ltcf1 24 32 Survey Survey NNP cord-260402-9b1ltcf1 24 33 Relation Relation NNP cord-260402-9b1ltcf1 24 34 of of IN cord-260402-9b1ltcf1 24 35 Smoking Smoking NNP cord-260402-9b1ltcf1 24 36 Status status NN cord-260402-9b1ltcf1 24 37 to to IN cord-260402-9b1ltcf1 24 38 Serum serum NN cord-260402-9b1ltcf1 24 39 Levels Levels NNPS cord-260402-9b1ltcf1 24 40 of of IN cord-260402-9b1ltcf1 24 41 N N NNP cord-260402-9b1ltcf1 24 42 - - HYPH cord-260402-9b1ltcf1 24 43 Terminal Terminal NNP cord-260402-9b1ltcf1 24 44 Pro Pro NNP cord-260402-9b1ltcf1 24 45 - - NNP cord-260402-9b1ltcf1 24 46 Brain Brain NNP cord-260402-9b1ltcf1 24 47 Natriuretic Natriuretic NNP cord-260402-9b1ltcf1 24 48 Peptide Peptide NNP cord-260402-9b1ltcf1 24 49 in in IN cord-260402-9b1ltcf1 24 50 Middle Middle NNP cord-260402-9b1ltcf1 24 51 - - HYPH cord-260402-9b1ltcf1 24 52 Aged aged JJ cord-260402-9b1ltcf1 24 53 Men Men NNPS cord-260402-9b1ltcf1 24 54 Without without IN cord-260402-9b1ltcf1 24 55 Overt overt JJ cord-260402-9b1ltcf1 24 56 Cardiovascular cardiovascular JJ cord-260402-9b1ltcf1 24 57 Disease Disease NNP cord-260402-9b1ltcf1 25 1 J J NNP cord-260402-9b1ltcf1 25 2 o o NN cord-260402-9b1ltcf1 25 3 u u NN cord-260402-9b1ltcf1 25 4 r r NN cord-260402-9b1ltcf1 25 5 n n NN cord-260402-9b1ltcf1 25 6 a a DT cord-260402-9b1ltcf1 25 7 l l NN cord-260402-9b1ltcf1 25 8 P p NN cord-260402-9b1ltcf1 25 9 r r NN cord-260402-9b1ltcf1 25 10 e e NN cord-260402-9b1ltcf1 25 11 -p -p NN cord-260402-9b1ltcf1 26 1 r r LS cord-260402-9b1ltcf1 27 1 o o UH cord-260402-9b1ltcf1 27 2 o o NN cord-260402-9b1ltcf1 27 3 f f NN cord-260402-9b1ltcf1 27 4 _SP