id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-345058-jfzzngce	Baughn, Linda B.	Targeting TMPRSS2 in SARS-CoV-2 infection	2020-07-19		.txt	text/plain	1716	91	50	We show that expression levels of ACE2 and TMPRSS2 are overall comparable between males and females in multiple tissues suggesting that differences in the expression levels of TMPRSS2 and ACE2 in the lung and other non-sex-specific tissues may not explain the gender disparities in SARS CoV-2 severity. Given the increased severity of disease among older males with SARS-CoV-2 infection, we also address the potential roles of ACE2 and TMPRSS2 in their contribution to the sex differences in disease severity. Given the necessity of ACE2 and TMPRSS2 genes for SARS CoV-2 infection, we evaluated their expression in human tissues using data from the Genotype-Tissue Expression (GTEx) Project (https://gtexportal.org). Combined, these findings suggest that differences in the expression levels of TMPRSS2 and ACE2 in the lung and other non-sex-specific tissues likely do not explain the gender disparities in SARS CoV-2 severity. This suggests that expression differences of TMPRSS2 and ACE2 in the lung and other non-sex-specific tissues may not explain the gender disparities in SARS CoV-2 severity.	./cache/cord-345058-jfzzngce.txt	./txt/cord-345058-jfzzngce.txt