id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294728-fefkvg0a	Vick, Dan J.	GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENCY AND COVID-19 INFECTION	2020-06-06		.txt	text/plain	950	74	51	title: GLUCOSE-6-PHOSPHATE DEHYDROGENASE (G6PD) DEFICIENCY AND COVID-19 INFECTION 2 There is evidence to suggest an association between G6PD deficiency and increased susceptibility to, and severity of illness with, COVID-19 infection. Vascular endothelial dysfunction and coagulopathy have been suggested as complications of COVID-19, based on a report of large vessel ischemic stroke occurring in five U.S. patients under age 50, including two without preexisting conditions. However, a recent report described an acute hemolytic episode occurring in a COVID-19 patient with G6PD deficiency who was treated with hydroxychloroquine. 12 Hydroxychloroquine may increase the oxidative stress in COVID-19 patients with G6PD deficiency, thereby serving as a trigger for hemolytic anemia. Studies are needed to determine whether a positive correlation exists between G6PD deficiency and COVID-19, with respect to increased susceptibility to infection and severity of illness. Acute hemolysis by hydroxychloroquine was observed in G6PD-deficient patient with severe COVID-19 related lung injury	./cache/cord-294728-fefkvg0a.txt	./txt/cord-294728-fefkvg0a.txt