id author title date pages extension mime words sentences flesch summary cache txt cord-009027-uqsayb4d Sirtori, Carlo AUSTRALIA ANTIGEN, CORONAVIRUS, AND REVERSE TRANSCRIPTASE IN VIRAL HEPATITIS 1971-07-31 .txt text/plain 934 67 65 SIR,-The discovery of a reverse transcriptase in Australia antigen by Hirschman and his colleagues strongly suggests that the antigen is associated with an R.N.A. virus 2; and this idea is corroborated by the finding of small amounts of R.N.A. in the same antigen.3 3 All this is in keeping with our previous studies of the acute-hepatitis liver with the electron microscope,4>5 revealing the simultaneous presence of Australia antigen and coronaviruses, and showing how the particles of Australia antigen, present in the cytoplasm, fell together to form coronavirus membranes. We have tried to cultivate bits of hepatitis liver containing both the Australia antigen and the coronavirus on KB cells,5 and we have seen that the KB cells developed clusters of particles in their cytoplasm, suggesting the early stages of Australia-antigen formation; on the other hand, Perhaps the coronavirus, or adult form of the virus, occurs only exceptionally or is very short-lived. ./cache/cord-009027-uqsayb4d.txt ./txt/cord-009027-uqsayb4d.txt