id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-308288-3ewdy5l3	Domingues, Renan Barros	First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease	2020-06-20		.txt	text/plain	1163	67	48	However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating disease so far. Here, we report a case of a patient with mild respiratory symptoms and neurological manifestations compatible with clinically isolated syndrome. The viral genome of SARS-COV-2 was detected and sequenced in CSF with 99.74–100% similarity between the patient virus and worldwide sequences. This report suggests a possible association of SARS-COV-2 infection with neurological symptoms of demyelinating disease, even in the absence of relevant upper respiratory tract infection signs. The viral genome was demonstrated by RT-PCR technique in cerebrospinal fluid sample (CSF), suggesting that the virus has the ability to infect central nervous system (CNS) [1] . However, no case has been described of an association between SARS-COV-2 and CNS demyelinating disease so far. This case report suggests a possible association between CNS focal symptoms compatible with demyelinating disease and SARS-COV-2 infection.	./cache/cord-308288-3ewdy5l3.txt	./txt/cord-308288-3ewdy5l3.txt