id	sid	tid	token	lemma	pos
cord-270709-jahnjvyk	1	1	key	key	NN
cord-270709-jahnjvyk	1	2	:	:	:
cord-270709-jahnjvyk	1	3	cord-270709-jahnjvyk	cord-270709-jahnjvyk	.
cord-270709-jahnjvyk	2	1	authors	author	NNS
cord-270709-jahnjvyk	2	2	:	:	:
cord-270709-jahnjvyk	2	3	Hasford	Hasford	NNP
cord-270709-jahnjvyk	2	4	,	,	,
cord-270709-jahnjvyk	2	5	Joerg	Joerg	NNP
cord-270709-jahnjvyk	2	6	title	title	NN
cord-270709-jahnjvyk	2	7	:	:	:
cord-270709-jahnjvyk	2	8	Large	large	JJ
cord-270709-jahnjvyk	2	9	Simple	simple	JJ
cord-270709-jahnjvyk	2	10	Double	double	JJ
cord-270709-jahnjvyk	2	11	-	-	HYPH
cord-270709-jahnjvyk	2	12	Blind	blind	JJ
cord-270709-jahnjvyk	2	13	Randomized	Randomized	NNP
cord-270709-jahnjvyk	2	14	Trials	Trials	NNPS
cord-270709-jahnjvyk	2	15	for	for	IN
cord-270709-jahnjvyk	2	16	the	the	DT
cord-270709-jahnjvyk	2	17	Rapid	Rapid	NNP
cord-270709-jahnjvyk	2	18	Assessment	Assessment	NNP
cord-270709-jahnjvyk	2	19	of	of	IN
cord-270709-jahnjvyk	2	20	the	the	DT
cord-270709-jahnjvyk	2	21	Effectiveness	Effectiveness	NNP
cord-270709-jahnjvyk	2	22	of	of	IN
cord-270709-jahnjvyk	2	23	COVID-19	COVID-19	NNP
cord-270709-jahnjvyk	2	24	Vaccines	Vaccines	NNPS
cord-270709-jahnjvyk	2	25	date	date	NN
cord-270709-jahnjvyk	2	26	:	:	:
cord-270709-jahnjvyk	2	27	2020	2020	CD
cord-270709-jahnjvyk	2	28	-	-	HYPH
cord-270709-jahnjvyk	2	29	08	08	CD
cord-270709-jahnjvyk	2	30	-	-	SYM
cord-270709-jahnjvyk	2	31	26	26	CD
cord-270709-jahnjvyk	2	32	journal	journal	NN
cord-270709-jahnjvyk	2	33	:	:	:
cord-270709-jahnjvyk	3	1	J	J	NNP
cord-270709-jahnjvyk	3	2	Infect	infect	VBP
cord-270709-jahnjvyk	3	3	Dis	Dis	NNP
cord-270709-jahnjvyk	3	4	DOI	doi	NN
cord-270709-jahnjvyk	3	5	:	:	:
cord-270709-jahnjvyk	3	6	10.1093	10.1093	CD
cord-270709-jahnjvyk	3	7	/	/	SYM
cord-270709-jahnjvyk	3	8	infdis	infdis	NNP
cord-270709-jahnjvyk	3	9	/	/	SYM
cord-270709-jahnjvyk	3	10	jiaa456	jiaa456	NNP
cord-270709-jahnjvyk	3	11	sha	sha	NNP
cord-270709-jahnjvyk	3	12	:	:	:
cord-270709-jahnjvyk	3	13	2ac00f1a4d47fff50aa8d7828387641c1003e190	2ac00f1a4d47fff50aa8d7828387641c1003e190	CD
cord-270709-jahnjvyk	3	14	doc_id	doc_id	CD
cord-270709-jahnjvyk	3	15	:	:	:
cord-270709-jahnjvyk	3	16	270709	270709	CD
cord-270709-jahnjvyk	3	17	cord_uid	cord_uid	NNS
cord-270709-jahnjvyk	3	18	:	:	:
cord-270709-jahnjvyk	4	1	jahnjvyk	jahnjvyk	NNP
cord-270709-jahnjvyk	4	2	nan	nan	NNP
cord-270709-jahnjvyk	4	3	Large	Large	NNP
cord-270709-jahnjvyk	4	4	Simple	Simple	NNP
cord-270709-jahnjvyk	4	5	Double	double	JJ
cord-270709-jahnjvyk	4	6	-	-	HYPH
cord-270709-jahnjvyk	4	7	Blind	blind	JJ
cord-270709-jahnjvyk	4	8	Randomized	Randomized	NNP
cord-270709-jahnjvyk	4	9	Trials	Trials	NNPS
cord-270709-jahnjvyk	4	10	for	for	IN
cord-270709-jahnjvyk	4	11	the	the	DT
cord-270709-jahnjvyk	4	12	Rapid	Rapid	NNP
cord-270709-jahnjvyk	4	13	Assessment	Assessment	NNP
cord-270709-jahnjvyk	4	14	of	of	IN
cord-270709-jahnjvyk	4	15	the	the	DT
cord-270709-jahnjvyk	4	16	Effectiveness	Effectiveness	NNP
cord-270709-jahnjvyk	4	17	of	of	IN
cord-270709-jahnjvyk	4	18	COVID-19	COVID-19	NNP
cord-270709-jahnjvyk	4	19	Vaccines	Vaccines	NNPS
cord-270709-jahnjvyk	4	20	to	to	IN
cord-270709-jahnjvyk	4	21	the	the	DT
cord-270709-jahnjvyk	4	22	editor-	editor-	NN
cord-270709-jahnjvyk	5	1	The	the	DT
cord-270709-jahnjvyk	5	2	coronavirus	coronavirus	NN
cord-270709-jahnjvyk	5	3	disease	disease	NN
cord-270709-jahnjvyk	5	4	2019	2019	CD
cord-270709-jahnjvyk	5	5	(	(	-LRB-
cord-270709-jahnjvyk	5	6	COVID-19	COVID-19	NNP
cord-270709-jahnjvyk	5	7	)	)	-RRB-
cord-270709-jahnjvyk	5	8	pandemic	pandemic	NN
cord-270709-jahnjvyk	5	9	has	have	VBZ
cord-270709-jahnjvyk	5	10	brought	bring	VBN
cord-270709-jahnjvyk	5	11	not	not	RB
cord-270709-jahnjvyk	5	12	only	only	RB
cord-270709-jahnjvyk	5	13	far	far	RB
cord-270709-jahnjvyk	5	14	too	too	RB
cord-270709-jahnjvyk	5	15	many	many	JJ
cord-270709-jahnjvyk	5	16	losses	loss	NNS
cord-270709-jahnjvyk	5	17	of	of	IN
cord-270709-jahnjvyk	5	18	human	human	JJ
cord-270709-jahnjvyk	5	19	lives	life	NNS
cord-270709-jahnjvyk	5	20	but	but	CC
cord-270709-jahnjvyk	5	21	an	an	DT
cord-270709-jahnjvyk	5	22	economic	economic	JJ
cord-270709-jahnjvyk	5	23	crisis	crisis	NN
cord-270709-jahnjvyk	5	24	as	as	RB
cord-270709-jahnjvyk	5	25	well	well	RB
cord-270709-jahnjvyk	5	26	.	.	.
cord-270709-jahnjvyk	6	1	Thus	thus	RB
cord-270709-jahnjvyk	6	2	,	,	,
cord-270709-jahnjvyk	6	3	effective	effective	JJ
cord-270709-jahnjvyk	6	4	treatments	treatment	NNS
cord-270709-jahnjvyk	6	5	and	and	CC
cord-270709-jahnjvyk	6	6	vaccines	vaccine	NNS
cord-270709-jahnjvyk	6	7	for	for	IN
cord-270709-jahnjvyk	6	8	severe	severe	JJ
cord-270709-jahnjvyk	6	9	acute	acute	JJ
cord-270709-jahnjvyk	6	10	respiratory	respiratory	JJ
cord-270709-jahnjvyk	6	11	syndrome	syndrome	NN
cord-270709-jahnjvyk	6	12	coronavirus	coronavirus	NN
cord-270709-jahnjvyk	6	13	2	2	CD
cord-270709-jahnjvyk	6	14	(	(	-LRB-
cord-270709-jahnjvyk	6	15	SARS	SARS	NNP
cord-270709-jahnjvyk	6	16	-	-	HYPH
cord-270709-jahnjvyk	6	17	CoV-2	CoV-2	NNP
cord-270709-jahnjvyk	6	18	)	)	-RRB-
cord-270709-jahnjvyk	6	19	are	be	VBP
cord-270709-jahnjvyk	6	20	urgently	urgently	RB
cord-270709-jahnjvyk	6	21	needed	need	VBN
cord-270709-jahnjvyk	6	22	.	.	.
cord-270709-jahnjvyk	7	1	Eyal	Eyal	NNP
cord-270709-jahnjvyk	7	2	et	et	FW
cord-270709-jahnjvyk	7	3	al	al	NNP
cord-270709-jahnjvyk	7	4	have	have	VBP
cord-270709-jahnjvyk	7	5	discussed	discuss	VBN
cord-270709-jahnjvyk	7	6	challenge	challenge	NN
cord-270709-jahnjvyk	7	7	studies	study	NNS
cord-270709-jahnjvyk	7	8	[	[	-LRB-
cord-270709-jahnjvyk	7	9	1	1	CD
cord-270709-jahnjvyk	7	10	]	]	-RRB-
cord-270709-jahnjvyk	7	11	to	to	TO
cord-270709-jahnjvyk	7	12	accelerate	accelerate	VB
cord-270709-jahnjvyk	7	13	the	the	DT
cord-270709-jahnjvyk	7	14	assessment	assessment	NN
cord-270709-jahnjvyk	7	15	of	of	IN
cord-270709-jahnjvyk	7	16	vaccine	vaccine	NN
cord-270709-jahnjvyk	7	17	effectiveness	effectiveness	NN
cord-270709-jahnjvyk	7	18	.	.	.
cord-270709-jahnjvyk	8	1	In	in	IN
cord-270709-jahnjvyk	8	2	a	a	DT
cord-270709-jahnjvyk	8	3	challenge	challenge	NN
cord-270709-jahnjvyk	8	4	study	study	NN
cord-270709-jahnjvyk	8	5	,	,	,
cord-270709-jahnjvyk	8	6	all	all	DT
cord-270709-jahnjvyk	8	7	participants	participant	NNS
cord-270709-jahnjvyk	8	8	are	be	VBP
cord-270709-jahnjvyk	8	9	vaccinated	vaccinate	VBN
cord-270709-jahnjvyk	8	10	with	with	IN
cord-270709-jahnjvyk	8	11	placebo	placebo	NN
cord-270709-jahnjvyk	8	12	or	or	CC
cord-270709-jahnjvyk	8	13	with	with	IN
cord-270709-jahnjvyk	8	14	the	the	DT
cord-270709-jahnjvyk	8	15	test	test	NN
cord-270709-jahnjvyk	8	16	vaccine	vaccine	NN
cord-270709-jahnjvyk	8	17	and	and	CC
cord-270709-jahnjvyk	8	18	are	be	VBP
cord-270709-jahnjvyk	8	19	then	then	RB
cord-270709-jahnjvyk	8	20	intentionally	intentionally	RB
cord-270709-jahnjvyk	8	21	exposed	expose	VBN
cord-270709-jahnjvyk	8	22	to	to	IN
cord-270709-jahnjvyk	8	23	doses	dose	NNS
cord-270709-jahnjvyk	8	24	of	of	IN
cord-270709-jahnjvyk	8	25	SARS	SARS	NNP
cord-270709-jahnjvyk	8	26	-	-	HYPH
cord-270709-jahnjvyk	8	27	CoV-2	CoV-2	NNP
cord-270709-jahnjvyk	8	28	.	.	.
cord-270709-jahnjvyk	9	1	There	there	EX
cord-270709-jahnjvyk	9	2	is	be	VBZ
cord-270709-jahnjvyk	9	3	already	already	RB
cord-270709-jahnjvyk	9	4	a	a	DT
cord-270709-jahnjvyk	9	5	worldwide	worldwide	JJ
cord-270709-jahnjvyk	9	6	initiative	initiative	NN
cord-270709-jahnjvyk	9	7	to	to	TO
cord-270709-jahnjvyk	9	8	register	register	VB
cord-270709-jahnjvyk	9	9	volunteers	volunteer	NNS
cord-270709-jahnjvyk	9	10	for	for	IN
cord-270709-jahnjvyk	9	11	such	such	JJ
cord-270709-jahnjvyk	9	12	studies	study	NNS
cord-270709-jahnjvyk	9	13	[	[	-LRB-
cord-270709-jahnjvyk	9	14	2	2	CD
cord-270709-jahnjvyk	9	15	]	]	-RRB-
cord-270709-jahnjvyk	9	16	.	.	.
cord-270709-jahnjvyk	10	1	As	as	IN
cord-270709-jahnjvyk	10	2	all	all	DT
cord-270709-jahnjvyk	10	3	participants	participant	NNS
cord-270709-jahnjvyk	10	4	have	have	VBP
cord-270709-jahnjvyk	10	5	been	be	VBN
cord-270709-jahnjvyk	10	6	exposed	expose	VBN
cord-270709-jahnjvyk	10	7	,	,	,
cord-270709-jahnjvyk	10	8	the	the	DT
cord-270709-jahnjvyk	10	9	effectiveness	effectiveness	NN
cord-270709-jahnjvyk	10	10	of	of	IN
cord-270709-jahnjvyk	10	11	a	a	DT
cord-270709-jahnjvyk	10	12	vaccine	vaccine	NN
cord-270709-jahnjvyk	10	13	can	can	MD
cord-270709-jahnjvyk	10	14	be	be	VB
cord-270709-jahnjvyk	10	15	assessed	assess	VBN
cord-270709-jahnjvyk	10	16	with	with	IN
cord-270709-jahnjvyk	10	17	smaller	small	JJR
cord-270709-jahnjvyk	10	18	sample	sample	NN
cord-270709-jahnjvyk	10	19	sizes	size	NNS
cord-270709-jahnjvyk	10	20	and	and	CC
cord-270709-jahnjvyk	10	21	possibly	possibly	RB
cord-270709-jahnjvyk	10	22	more	more	RBR
cord-270709-jahnjvyk	10	23	quickly	quickly	RB
cord-270709-jahnjvyk	10	24	compared	compare	VBN
cord-270709-jahnjvyk	10	25	to	to	IN
cord-270709-jahnjvyk	10	26	the	the	DT
cord-270709-jahnjvyk	10	27	conventional	conventional	JJ
cord-270709-jahnjvyk	10	28	trial	trial	NN
cord-270709-jahnjvyk	10	29	with	with	IN
cord-270709-jahnjvyk	10	30	community	community	NN
cord-270709-jahnjvyk	10	31	participants	participant	NNS
cord-270709-jahnjvyk	10	32	;	;	:
cord-270709-jahnjvyk	10	33	however	however	RB
cord-270709-jahnjvyk	10	34	,	,	,
cord-270709-jahnjvyk	10	35	challenge	challenge	NN
cord-270709-jahnjvyk	10	36	studies	study	NNS
cord-270709-jahnjvyk	10	37	are	be	VBP
cord-270709-jahnjvyk	10	38	accompanied	accompany	VBN
cord-270709-jahnjvyk	10	39	by	by	IN
cord-270709-jahnjvyk	10	40	serious	serious	JJ
cord-270709-jahnjvyk	10	41	ethical	ethical	JJ
cord-270709-jahnjvyk	10	42	issues	issue	NNS
cord-270709-jahnjvyk	10	43	[	[	-LRB-
cord-270709-jahnjvyk	10	44	3	3	CD
cord-270709-jahnjvyk	10	45	]	]	-RRB-
cord-270709-jahnjvyk	10	46	.	.	.
cord-270709-jahnjvyk	11	1	First	first	RB
cord-270709-jahnjvyk	11	2	,	,	,
cord-270709-jahnjvyk	11	3	the	the	DT
cord-270709-jahnjvyk	11	4	characteristics	characteristic	NNS
cord-270709-jahnjvyk	11	5	of	of	IN
cord-270709-jahnjvyk	11	6	a	a	DT
cord-270709-jahnjvyk	11	7	distinct	distinct	JJ
cord-270709-jahnjvyk	11	8	group	group	NN
cord-270709-jahnjvyk	11	9	of	of	IN
cord-270709-jahnjvyk	11	10	volunteers	volunteer	NNS
cord-270709-jahnjvyk	11	11	without	without	IN
cord-270709-jahnjvyk	11	12	risks	risk	NNS
cord-270709-jahnjvyk	11	13	for	for	IN
cord-270709-jahnjvyk	11	14	fatal	fatal	JJ
cord-270709-jahnjvyk	11	15	progression	progression	NN
cord-270709-jahnjvyk	11	16	or	or	CC
cord-270709-jahnjvyk	11	17	serious	serious	JJ
cord-270709-jahnjvyk	11	18	late	late	JJ
cord-270709-jahnjvyk	11	19	complications	complication	NNS
cord-270709-jahnjvyk	11	20	of	of	IN
cord-270709-jahnjvyk	11	21	COVID-19	covid-19	JJ
cord-270709-jahnjvyk	11	22	need	need	NN
cord-270709-jahnjvyk	11	23	to	to	TO
cord-270709-jahnjvyk	11	24	be	be	VB
cord-270709-jahnjvyk	11	25	reliably	reliably	RB
cord-270709-jahnjvyk	11	26	known	know	VBN
cord-270709-jahnjvyk	11	27	.	.	.
cord-270709-jahnjvyk	12	1	Second	second	RB
cord-270709-jahnjvyk	12	2	,	,	,
cord-270709-jahnjvyk	12	3	a	a	DT
cord-270709-jahnjvyk	12	4	highly	highly	RB
cord-270709-jahnjvyk	12	5	effective	effective	JJ
cord-270709-jahnjvyk	12	6	and	and	CC
cord-270709-jahnjvyk	12	7	safe	safe	JJ
cord-270709-jahnjvyk	12	8	treatment	treatment	NN
cord-270709-jahnjvyk	12	9	should	should	MD
cord-270709-jahnjvyk	12	10	be	be	VB
cord-270709-jahnjvyk	12	11	available	available	JJ
cord-270709-jahnjvyk	12	12	for	for	IN
cord-270709-jahnjvyk	12	13	patients	patient	NNS
cord-270709-jahnjvyk	12	14	with	with	IN
cord-270709-jahnjvyk	12	15	COVID-19	COVID-19	NNP
cord-270709-jahnjvyk	12	16	,	,	,
cord-270709-jahnjvyk	12	17	so	so	IN
cord-270709-jahnjvyk	12	18	that	that	IN
cord-270709-jahnjvyk	12	19	fatalities	fatality	NNS
cord-270709-jahnjvyk	12	20	and	and	CC
cord-270709-jahnjvyk	12	21	persistent	persistent	JJ
cord-270709-jahnjvyk	12	22	adverse	adverse	JJ
cord-270709-jahnjvyk	12	23	consequences	consequence	NNS
cord-270709-jahnjvyk	12	24	can	can	MD
cord-270709-jahnjvyk	12	25	be	be	VB
cord-270709-jahnjvyk	12	26	avoided	avoid	VBN
cord-270709-jahnjvyk	12	27	.	.	.
cord-270709-jahnjvyk	13	1	Both	both	CC
cord-270709-jahnjvyk	13	2	these	these	DT
cord-270709-jahnjvyk	13	3	problems	problem	NNS
cord-270709-jahnjvyk	13	4	are	be	VBP
cord-270709-jahnjvyk	13	5	not	not	RB
cord-270709-jahnjvyk	13	6	yet	yet	RB
cord-270709-jahnjvyk	13	7	solved	solve	VBN
cord-270709-jahnjvyk	13	8	.	.	.
cord-270709-jahnjvyk	14	1	Third	third	RB
cord-270709-jahnjvyk	14	2	,	,	,
cord-270709-jahnjvyk	14	3	the	the	DT
cord-270709-jahnjvyk	14	4	consent	consent	NN
cord-270709-jahnjvyk	14	5	of	of	IN
cord-270709-jahnjvyk	14	6	the	the	DT
cord-270709-jahnjvyk	14	7	volunteer	volunteer	NN
cord-270709-jahnjvyk	14	8	must	must	MD
cord-270709-jahnjvyk	14	9	be	be	VB
cord-270709-jahnjvyk	14	10	with	with	IN
cord-270709-jahnjvyk	14	11	their	-PRON-	PRP$
cord-270709-jahnjvyk	14	12	full	full	JJ
cord-270709-jahnjvyk	14	13	understanding	understanding	NN
cord-270709-jahnjvyk	14	14	of	of	IN
cord-270709-jahnjvyk	14	15	comprehensive	comprehensive	JJ
cord-270709-jahnjvyk	14	16	information	information	NN
cord-270709-jahnjvyk	14	17	,	,	,
cord-270709-jahnjvyk	14	18	including	include	VBG
cord-270709-jahnjvyk	14	19	appreciation	appreciation	NN
cord-270709-jahnjvyk	14	20	of	of	IN
cord-270709-jahnjvyk	14	21	potential	potential	JJ
cord-270709-jahnjvyk	14	22	long	long	JJ
cord-270709-jahnjvyk	14	23	-	-	HYPH
cord-270709-jahnjvyk	14	24	term	term	NN
cord-270709-jahnjvyk	14	25	consequences	consequence	NNS
cord-270709-jahnjvyk	14	26	.	.	.
cord-270709-jahnjvyk	15	1	It	-PRON-	PRP
cord-270709-jahnjvyk	15	2	may	may	MD
cord-270709-jahnjvyk	15	3	be	be	VB
cord-270709-jahnjvyk	15	4	questioned	question	VBN
cord-270709-jahnjvyk	15	5	,	,	,
cord-270709-jahnjvyk	15	6	however	however	RB
cord-270709-jahnjvyk	15	7	,	,	,
cord-270709-jahnjvyk	15	8	whether	whether	IN
cord-270709-jahnjvyk	15	9	someone	someone	NN
cord-270709-jahnjvyk	15	10	at	at	IN
cord-270709-jahnjvyk	15	11	age	age	NN
cord-270709-jahnjvyk	15	12	20	20	CD
cord-270709-jahnjvyk	15	13	years	year	NNS
cord-270709-jahnjvyk	15	14	or	or	CC
cord-270709-jahnjvyk	15	15	so	so	RB
cord-270709-jahnjvyk	15	16	can	can	MD
cord-270709-jahnjvyk	15	17	imagine	imagine	VB
cord-270709-jahnjvyk	15	18	the	the	DT
cord-270709-jahnjvyk	15	19	consequences	consequence	NNS
cord-270709-jahnjvyk	15	20	of	of	IN
cord-270709-jahnjvyk	15	21	a	a	DT
cord-270709-jahnjvyk	15	22	scarred	scarred	JJ
cord-270709-jahnjvyk	15	23	lung	lung	NN
cord-270709-jahnjvyk	15	24	occurring	occur	VBG
cord-270709-jahnjvyk	15	25	many	many	JJ
cord-270709-jahnjvyk	15	26	years	year	NNS
cord-270709-jahnjvyk	15	27	later	later	RB
cord-270709-jahnjvyk	15	28	.	.	.
cord-270709-jahnjvyk	16	1	Finally	finally	RB
cord-270709-jahnjvyk	16	2	,	,	,
cord-270709-jahnjvyk	16	3	it	-PRON-	PRP
cord-270709-jahnjvyk	16	4	can	can	MD
cord-270709-jahnjvyk	16	5	not	not	RB
cord-270709-jahnjvyk	16	6	be	be	VB
cord-270709-jahnjvyk	16	7	taken	take	VBN
cord-270709-jahnjvyk	16	8	for	for	IN
cord-270709-jahnjvyk	16	9	granted	grant	VBN
cord-270709-jahnjvyk	16	10	that	that	IN
cord-270709-jahnjvyk	16	11	a	a	DT
cord-270709-jahnjvyk	16	12	vaccine	vaccine	NN
cord-270709-jahnjvyk	16	13	that	that	WDT
cord-270709-jahnjvyk	16	14	works	work	VBZ
cord-270709-jahnjvyk	16	15	in	in	IN
cord-270709-jahnjvyk	16	16	a	a	DT
cord-270709-jahnjvyk	16	17	challenge	challenge	NN
cord-270709-jahnjvyk	16	18	study	study	NN
cord-270709-jahnjvyk	16	19	with	with	IN
cord-270709-jahnjvyk	16	20	young	young	JJ
cord-270709-jahnjvyk	16	21	,	,	,
cord-270709-jahnjvyk	16	22	healthy	healthy	JJ
cord-270709-jahnjvyk	16	23	volunteers	volunteer	NNS
cord-270709-jahnjvyk	16	24	will	will	MD
cord-270709-jahnjvyk	16	25	work	work	VB
cord-270709-jahnjvyk	16	26	in	in	IN
cord-270709-jahnjvyk	16	27	elderly	elderly	JJ
cord-270709-jahnjvyk	16	28	patients	patient	NNS
cord-270709-jahnjvyk	16	29	with	with	IN
cord-270709-jahnjvyk	16	30	possible	possible	JJ
cord-270709-jahnjvyk	16	31	comorbid	comorbid	NN
cord-270709-jahnjvyk	16	32	conditions	condition	NNS
cord-270709-jahnjvyk	16	33	[	[	-LRB-
cord-270709-jahnjvyk	16	34	4	4	CD
cord-270709-jahnjvyk	16	35	]	]	-RRB-
cord-270709-jahnjvyk	16	36	.	.	.
cord-270709-jahnjvyk	17	1	Thus	thus	RB
cord-270709-jahnjvyk	17	2	,	,	,
cord-270709-jahnjvyk	17	3	even	even	RB
cord-270709-jahnjvyk	17	4	the	the	DT
cord-270709-jahnjvyk	17	5	social	social	JJ
cord-270709-jahnjvyk	17	6	value	value	NN
cord-270709-jahnjvyk	17	7	of	of	IN
cord-270709-jahnjvyk	17	8	challenge	challenge	NN
cord-270709-jahnjvyk	17	9	trials	trial	NNS
cord-270709-jahnjvyk	17	10	can	can	MD
cord-270709-jahnjvyk	17	11	be	be	VB
cord-270709-jahnjvyk	17	12	questioned	question	VBN
cord-270709-jahnjvyk	17	13	.	.	.
cord-270709-jahnjvyk	18	1	Fortunately	fortunately	RB
cord-270709-jahnjvyk	18	2	,	,	,
cord-270709-jahnjvyk	18	3	there	there	EX
cord-270709-jahnjvyk	18	4	is	be	VBZ
cord-270709-jahnjvyk	18	5	an	an	DT
cord-270709-jahnjvyk	18	6	ethically	ethically	RB
cord-270709-jahnjvyk	18	7	more	more	RBR
cord-270709-jahnjvyk	18	8	acceptable	acceptable	JJ
cord-270709-jahnjvyk	18	9	alternative	alternative	NN
cord-270709-jahnjvyk	18	10	for	for	IN
cord-270709-jahnjvyk	18	11	an	an	DT
cord-270709-jahnjvyk	18	12	accelerated	accelerated	JJ
cord-270709-jahnjvyk	18	13	evaluation	evaluation	NN
cord-270709-jahnjvyk	18	14	of	of	IN
cord-270709-jahnjvyk	18	15	SARS	SARS	NNP
cord-270709-jahnjvyk	18	16	-	-	HYPH
cord-270709-jahnjvyk	18	17	CoV-2	CoV-2	NNP
cord-270709-jahnjvyk	18	18	vaccines	vaccine	NNS
cord-270709-jahnjvyk	18	19	.	.	.
cord-270709-jahnjvyk	19	1	The	the	DT
cord-270709-jahnjvyk	19	2	large	large	JJ
cord-270709-jahnjvyk	19	3	,	,	,
cord-270709-jahnjvyk	19	4	simple	simple	JJ
cord-270709-jahnjvyk	19	5	,	,	,
cord-270709-jahnjvyk	19	6	randomized	randomized	JJ
cord-270709-jahnjvyk	19	7	trial	trial	NN
cord-270709-jahnjvyk	19	8	(	(	-LRB-
cord-270709-jahnjvyk	19	9	LSRT	LSRT	NNP
cord-270709-jahnjvyk	19	10	)	)	-RRB-
cord-270709-jahnjvyk	19	11	,	,	,
cord-270709-jahnjvyk	19	12	as	as	IN
cord-270709-jahnjvyk	19	13	proposed	propose	VBN
cord-270709-jahnjvyk	19	14	by	by	IN
cord-270709-jahnjvyk	19	15	Yusuf	Yusuf	NNP
cord-270709-jahnjvyk	19	16	et	et	NNP
cord-270709-jahnjvyk	19	17	al	al	NNP
cord-270709-jahnjvyk	19	18	in	in	IN
cord-270709-jahnjvyk	19	19	1984	1984	CD
cord-270709-jahnjvyk	19	20	,	,	,
cord-270709-jahnjvyk	19	21	is	be	VBZ
cord-270709-jahnjvyk	19	22	a	a	DT
cord-270709-jahnjvyk	19	23	reliable	reliable	JJ
cord-270709-jahnjvyk	19	24	,	,	,
cord-270709-jahnjvyk	19	25	methodologically	methodologically	RB
cord-270709-jahnjvyk	19	26	and	and	CC
cord-270709-jahnjvyk	19	27	ethically	ethically	RB
cord-270709-jahnjvyk	19	28	sound	sound	JJ
cord-270709-jahnjvyk	19	29	alternative	alternative	JJ
cord-270709-jahnjvyk	19	30	[	[	-LRB-
cord-270709-jahnjvyk	19	31	5	5	CD
cord-270709-jahnjvyk	19	32	]	]	-RRB-
cord-270709-jahnjvyk	19	33	.	.	.
cord-270709-jahnjvyk	20	1	Characteristics	characteristic	NNS
cord-270709-jahnjvyk	20	2	of	of	IN
cord-270709-jahnjvyk	20	3	this	this	DT
cord-270709-jahnjvyk	20	4	design	design	NN
cord-270709-jahnjvyk	20	5	include	include	VBP
cord-270709-jahnjvyk	20	6	:	:	:
cord-270709-jahnjvyk	20	7	wide	wide	JJ
cord-270709-jahnjvyk	20	8	,	,	,
cord-270709-jahnjvyk	20	9	simple	simple	JJ
cord-270709-jahnjvyk	20	10	eligibility	eligibility	NN
cord-270709-jahnjvyk	20	11	criteria	criterion	NNS
cord-270709-jahnjvyk	20	12	;	;	:
cord-270709-jahnjvyk	20	13	central	central	JJ
cord-270709-jahnjvyk	20	14	randomization	randomization	NN
cord-270709-jahnjvyk	20	15	;	;	:
cord-270709-jahnjvyk	20	16	recording	recording	NN
cord-270709-jahnjvyk	20	17	of	of	IN
cord-270709-jahnjvyk	20	18	only	only	JJ
cord-270709-jahnjvyk	20	19	few	few	JJ
cord-270709-jahnjvyk	20	20	baseline	baseline	JJ
cord-270709-jahnjvyk	20	21	data	datum	NNS
cord-270709-jahnjvyk	20	22	;	;	,
cord-270709-jahnjvyk	20	23	simple	simple	JJ
cord-270709-jahnjvyk	20	24	and	and	CC
cord-270709-jahnjvyk	20	25	short	short	JJ
cord-270709-jahnjvyk	20	26	-	-	HYPH
cord-270709-jahnjvyk	20	27	term	term	NN
cord-270709-jahnjvyk	20	28	treatment	treatment	NN
cord-270709-jahnjvyk	20	29	;	;	,
cord-270709-jahnjvyk	20	30	reduced	reduce	VBN
cord-270709-jahnjvyk	20	31	or	or	CC
cord-270709-jahnjvyk	20	32	no	no	DT
cord-270709-jahnjvyk	20	33	follow	follow	VB
cord-270709-jahnjvyk	20	34	-	-	HYPH
cord-270709-jahnjvyk	20	35	up	up	NN
cord-270709-jahnjvyk	20	36	visits	visit	NNS
cord-270709-jahnjvyk	20	37	;	;	:
cord-270709-jahnjvyk	20	38	and	and	CC
cord-270709-jahnjvyk	20	39	outcome	outcome	VB
cord-270709-jahnjvyk	20	40	assessments	assessment	NNS
cord-270709-jahnjvyk	20	41	of	of	IN
cord-270709-jahnjvyk	20	42	hard	hard	JJ
cord-270709-jahnjvyk	20	43	endpoints	endpoint	NNS
cord-270709-jahnjvyk	20	44	,	,	,
cord-270709-jahnjvyk	20	45	preferably	preferably	RB
cord-270709-jahnjvyk	20	46	by	by	IN
cord-270709-jahnjvyk	20	47	registries	registry	NNS
cord-270709-jahnjvyk	20	48	.	.	.
cord-270709-jahnjvyk	21	1	Using	use	VBG
cord-270709-jahnjvyk	21	2	this	this	DT
cord-270709-jahnjvyk	21	3	design	design	NN
cord-270709-jahnjvyk	21	4	,	,	,
cord-270709-jahnjvyk	21	5	truly	truly	RB
cord-270709-jahnjvyk	21	6	large	large	JJ
cord-270709-jahnjvyk	21	7	randomized	randomized	JJ
cord-270709-jahnjvyk	21	8	trials	trial	NNS
cord-270709-jahnjvyk	21	9	with	with	IN
cord-270709-jahnjvyk	21	10	sample	sample	NN
cord-270709-jahnjvyk	21	11	sizes	size	NNS
cord-270709-jahnjvyk	21	12	beyond	beyond	IN
cord-270709-jahnjvyk	21	13	40	40	CD
cord-270709-jahnjvyk	21	14	000	000	CD
cord-270709-jahnjvyk	21	15	patients	patient	NNS
cord-270709-jahnjvyk	21	16	have	have	VBP
cord-270709-jahnjvyk	21	17	been	be	VBN
cord-270709-jahnjvyk	21	18	carried	carry	VBN
cord-270709-jahnjvyk	21	19	out	out	RP
cord-270709-jahnjvyk	21	20	and	and	CC
cord-270709-jahnjvyk	21	21	answered	answer	VBD
cord-270709-jahnjvyk	21	22	important	important	JJ
cord-270709-jahnjvyk	21	23	questions	question	NNS
cord-270709-jahnjvyk	21	24	[	[	-LRB-
cord-270709-jahnjvyk	21	25	6	6	CD
cord-270709-jahnjvyk	21	26	]	]	-RRB-
cord-270709-jahnjvyk	21	27	.	.	.
cord-270709-jahnjvyk	22	1	Probably	probably	RB
cord-270709-jahnjvyk	22	2	due	due	IN
cord-270709-jahnjvyk	22	3	to	to	IN
cord-270709-jahnjvyk	22	4	the	the	DT
cord-270709-jahnjvyk	22	5	increasing	increase	VBG
cord-270709-jahnjvyk	22	6	bureaucratization	bureaucratization	NN
cord-270709-jahnjvyk	22	7	of	of	IN
cord-270709-jahnjvyk	22	8	clinical	clinical	JJ
cord-270709-jahnjvyk	22	9	research	research	NN
cord-270709-jahnjvyk	22	10	activities	activity	NNS
cord-270709-jahnjvyk	22	11	,	,	,
cord-270709-jahnjvyk	22	12	including	include	VBG
cord-270709-jahnjvyk	22	13	very	very	RB
cord-270709-jahnjvyk	22	14	costly	costly	JJ
cord-270709-jahnjvyk	22	15	monitoring	monitoring	NN
cord-270709-jahnjvyk	22	16	,	,	,
cord-270709-jahnjvyk	22	17	in	in	IN
cord-270709-jahnjvyk	22	18	the	the	DT
cord-270709-jahnjvyk	22	19	last	last	JJ
cord-270709-jahnjvyk	22	20	20	20	CD
cord-270709-jahnjvyk	22	21	years	year	NNS
cord-270709-jahnjvyk	22	22	there	there	EX
cord-270709-jahnjvyk	22	23	has	have	VBZ
cord-270709-jahnjvyk	22	24	been	be	VBN
cord-270709-jahnjvyk	22	25	an	an	DT
cord-270709-jahnjvyk	22	26	almost	almost	RB
cord-270709-jahnjvyk	22	27	complete	complete	JJ
cord-270709-jahnjvyk	22	28	disappearance	disappearance	NN
cord-270709-jahnjvyk	22	29	of	of	IN
cord-270709-jahnjvyk	22	30	this	this	DT
cord-270709-jahnjvyk	22	31	trial	trial	NN
cord-270709-jahnjvyk	22	32	design	design	NN
cord-270709-jahnjvyk	22	33	.	.	.
cord-270709-jahnjvyk	23	1	At	at	IN
cord-270709-jahnjvyk	23	2	the	the	DT
cord-270709-jahnjvyk	23	3	current	current	JJ
cord-270709-jahnjvyk	23	4	stage	stage	NN
cord-270709-jahnjvyk	23	5	of	of	IN
cord-270709-jahnjvyk	23	6	evaluation	evaluation	NN
cord-270709-jahnjvyk	23	7	of	of	IN
cord-270709-jahnjvyk	23	8	the	the	DT
cord-270709-jahnjvyk	23	9	effectiveness	effectiveness	NN
cord-270709-jahnjvyk	23	10	of	of	IN
cord-270709-jahnjvyk	23	11	SARS	SARS	NNP
cord-270709-jahnjvyk	23	12	-	-	HYPH
cord-270709-jahnjvyk	23	13	CoV-2	CoV-2	NNP
cord-270709-jahnjvyk	23	14	vaccines	vaccine	NNS
cord-270709-jahnjvyk	23	15	,	,	,
cord-270709-jahnjvyk	23	16	this	this	DT
cord-270709-jahnjvyk	23	17	design	design	NN
cord-270709-jahnjvyk	23	18	should	should	MD
cord-270709-jahnjvyk	23	19	be	be	VB
cord-270709-jahnjvyk	23	20	revived	revive	VBN
cord-270709-jahnjvyk	23	21	as	as	IN
cord-270709-jahnjvyk	23	22	it	-PRON-	PRP
cord-270709-jahnjvyk	23	23	is	be	VBZ
cord-270709-jahnjvyk	23	24	ideally	ideally	RB
cord-270709-jahnjvyk	23	25	suited	suit	VBN
cord-270709-jahnjvyk	23	26	for	for	IN
cord-270709-jahnjvyk	23	27	this	this	DT
cord-270709-jahnjvyk	23	28	task	task	NN
cord-270709-jahnjvyk	23	29	.	.	.
cord-270709-jahnjvyk	24	1	There	there	EX
cord-270709-jahnjvyk	24	2	would	would	MD
cord-270709-jahnjvyk	24	3	be	be	VB
cord-270709-jahnjvyk	24	4	wide	wide	JJ
cord-270709-jahnjvyk	24	5	eligibility	eligibility	NN
cord-270709-jahnjvyk	24	6	criteria	criterion	NNS
cord-270709-jahnjvyk	24	7	with	with	IN
cord-270709-jahnjvyk	24	8	very	very	RB
cord-270709-jahnjvyk	24	9	few	few	JJ
cord-270709-jahnjvyk	24	10	exclusion	exclusion	NN
cord-270709-jahnjvyk	24	11	criteria	criterion	NNS
cord-270709-jahnjvyk	24	12	as	as	IN
cord-270709-jahnjvyk	24	13	the	the	DT
cord-270709-jahnjvyk	24	14	vaccine	vaccine	NN
cord-270709-jahnjvyk	24	15	should	should	MD
cord-270709-jahnjvyk	24	16	become	become	VB
cord-270709-jahnjvyk	24	17	available	available	JJ
cord-270709-jahnjvyk	24	18	for	for	IN
cord-270709-jahnjvyk	24	19	almost	almost	RB
cord-270709-jahnjvyk	24	20	everybody	everybody	NN
cord-270709-jahnjvyk	24	21	.	.	.
cord-270709-jahnjvyk	25	1	The	the	DT
cord-270709-jahnjvyk	25	2	investigational	investigational	JJ
cord-270709-jahnjvyk	25	3	vaccine	vaccine	NN
cord-270709-jahnjvyk	25	4	is	be	VBZ
cord-270709-jahnjvyk	25	5	a	a	DT
cord-270709-jahnjvyk	25	6	1	1	CD
cord-270709-jahnjvyk	25	7	or	or	CC
cord-270709-jahnjvyk	25	8	2-time	2-time	CD
cord-270709-jahnjvyk	25	9	treatment	treatment	NN
cord-270709-jahnjvyk	25	10	only	only	RB
cord-270709-jahnjvyk	25	11	and	and	CC
cord-270709-jahnjvyk	25	12	no	no	DT
cord-270709-jahnjvyk	25	13	follow	follow	VB
cord-270709-jahnjvyk	25	14	-	-	HYPH
cord-270709-jahnjvyk	25	15	up	up	RP
cord-270709-jahnjvyk	25	16	visits	visit	NNS
cord-270709-jahnjvyk	25	17	are	be	VBP
cord-270709-jahnjvyk	25	18	needed	need	VBN
cord-270709-jahnjvyk	25	19	.	.	.
cord-270709-jahnjvyk	26	1	The	the	DT
cord-270709-jahnjvyk	26	2	outcomes	outcome	NNS
cord-270709-jahnjvyk	26	3	,	,	,
cord-270709-jahnjvyk	26	4	COVID-19	covid-19	VBP
cord-270709-jahnjvyk	26	5	or	or	CC
cord-270709-jahnjvyk	26	6	death	death	NN
cord-270709-jahnjvyk	26	7	,	,	,
cord-270709-jahnjvyk	26	8	can	can	MD
cord-270709-jahnjvyk	26	9	be	be	VB
cord-270709-jahnjvyk	26	10	collected	collect	VBN
cord-270709-jahnjvyk	26	11	either	either	CC
cord-270709-jahnjvyk	26	12	by	by	IN
cord-270709-jahnjvyk	26	13	registries	registry	NNS
cord-270709-jahnjvyk	26	14	available	available	JJ
cord-270709-jahnjvyk	26	15	in	in	IN
cord-270709-jahnjvyk	26	16	many	many	JJ
cord-270709-jahnjvyk	26	17	countries	country	NNS
cord-270709-jahnjvyk	26	18	(	(	-LRB-
cord-270709-jahnjvyk	26	19	eg	eg	UH
cord-270709-jahnjvyk	26	20	,	,	,
cord-270709-jahnjvyk	26	21	in	in	IN
cord-270709-jahnjvyk	26	22	the	the	DT
cord-270709-jahnjvyk	26	23	United	United	NNP
cord-270709-jahnjvyk	26	24	States	States	NNP
cord-270709-jahnjvyk	26	25	,	,	,
cord-270709-jahnjvyk	26	26	United	United	NNP
cord-270709-jahnjvyk	26	27	Kingdom	Kingdom	NNP
cord-270709-jahnjvyk	26	28	,	,	,
cord-270709-jahnjvyk	26	29	or	or	CC
cord-270709-jahnjvyk	26	30	Scandinavia	Scandinavia	NNP
cord-270709-jahnjvyk	26	31	)	)	-RRB-
cord-270709-jahnjvyk	26	32	or	or	CC
cord-270709-jahnjvyk	26	33	by	by	IN
cord-270709-jahnjvyk	26	34	patient	patient	JJ
cord-270709-jahnjvyk	26	35	reporting	reporting	NN
cord-270709-jahnjvyk	26	36	.	.	.
cord-270709-jahnjvyk	27	1	Vaccine	vaccine	NN
cord-270709-jahnjvyk	27	2	safety	safety	NN
cord-270709-jahnjvyk	27	3	information	information	NN
cord-270709-jahnjvyk	27	4	can	can	MD
cord-270709-jahnjvyk	27	5	be	be	VB
cord-270709-jahnjvyk	27	6	collected	collect	VBN
cord-270709-jahnjvyk	27	7	by	by	IN
cord-270709-jahnjvyk	27	8	established	establish	VBN
cord-270709-jahnjvyk	27	9	systems	system	NNS
cord-270709-jahnjvyk	27	10	like	like	IN
cord-270709-jahnjvyk	27	11	the	the	DT
cord-270709-jahnjvyk	27	12	Vaccine	Vaccine	NNP
cord-270709-jahnjvyk	27	13	Safety	Safety	NNP
cord-270709-jahnjvyk	27	14	Datalink	Datalink	NNP
cord-270709-jahnjvyk	27	15	in	in	IN
cord-270709-jahnjvyk	27	16	the	the	DT
cord-270709-jahnjvyk	27	17	United	United	NNP
cord-270709-jahnjvyk	27	18	States	States	NNP
cord-270709-jahnjvyk	27	19	[	[	-LRB-
cord-270709-jahnjvyk	27	20	7	7	CD
cord-270709-jahnjvyk	27	21	]	]	-RRB-
cord-270709-jahnjvyk	27	22	,	,	,
cord-270709-jahnjvyk	27	23	prescription	prescription	NN
cord-270709-jahnjvyk	27	24	event	event	NN
cord-270709-jahnjvyk	27	25	monitoring	monitoring	NN
cord-270709-jahnjvyk	27	26	programs	program	NNS
cord-270709-jahnjvyk	27	27	(	(	-LRB-
cord-270709-jahnjvyk	27	28	eg	eg	UH
cord-270709-jahnjvyk	27	29	,	,	,
cord-270709-jahnjvyk	27	30	the	the	DT
cord-270709-jahnjvyk	27	31	Drug	Drug	NNP
cord-270709-jahnjvyk	27	32	Surveillance	Surveillance	NNP
cord-270709-jahnjvyk	27	33	Research	Research	NNP
cord-270709-jahnjvyk	27	34	Unit	Unit	NNP
cord-270709-jahnjvyk	27	35	in	in	IN
cord-270709-jahnjvyk	27	36	the	the	DT
cord-270709-jahnjvyk	27	37	United	United	NNP
cord-270709-jahnjvyk	27	38	Kingdom	Kingdom	NNP
cord-270709-jahnjvyk	27	39	[	[	-LRB-
cord-270709-jahnjvyk	27	40	8	8	CD
cord-270709-jahnjvyk	27	41	]	]	-RRB-
cord-270709-jahnjvyk	27	42	)	)	-RRB-
cord-270709-jahnjvyk	27	43	,	,	,
cord-270709-jahnjvyk	27	44	or	or	CC
cord-270709-jahnjvyk	27	45	by	by	IN
cord-270709-jahnjvyk	27	46	direct	direct	JJ
cord-270709-jahnjvyk	27	47	patient	patient	NN
cord-270709-jahnjvyk	27	48	safety	safety	NN
cord-270709-jahnjvyk	27	49	reporting	report	VBG
cord-270709-jahnjvyk	27	50	on	on	IN
cord-270709-jahnjvyk	27	51	websites	website	NNS
cord-270709-jahnjvyk	27	52	,	,	,
cord-270709-jahnjvyk	27	53	including	include	VBG
cord-270709-jahnjvyk	27	54	those	those	DT
cord-270709-jahnjvyk	27	55	accessible	accessible	JJ
cord-270709-jahnjvyk	27	56	with	with	IN
cord-270709-jahnjvyk	27	57	smartphones	smartphone	NNS
cord-270709-jahnjvyk	27	58	[	[	-LRB-
cord-270709-jahnjvyk	27	59	9	9	CD
cord-270709-jahnjvyk	27	60	]	]	-RRB-
cord-270709-jahnjvyk	27	61	,	,	,
cord-270709-jahnjvyk	27	62	which	which	WDT
cord-270709-jahnjvyk	27	63	can	can	MD
cord-270709-jahnjvyk	27	64	be	be	VB
cord-270709-jahnjvyk	27	65	specifically	specifically	RB
cord-270709-jahnjvyk	27	66	designed	design	VBN
cord-270709-jahnjvyk	27	67	for	for	IN
cord-270709-jahnjvyk	27	68	vaccine	vaccine	NN
cord-270709-jahnjvyk	27	69	trials	trial	NNS
cord-270709-jahnjvyk	27	70	.	.	.
cord-270709-jahnjvyk	28	1	Among	among	IN
cord-270709-jahnjvyk	28	2	the	the	DT
cord-270709-jahnjvyk	28	3	advantages	advantage	NNS
cord-270709-jahnjvyk	28	4	of	of	IN
cord-270709-jahnjvyk	28	5	using	use	VBG
cord-270709-jahnjvyk	28	6	the	the	DT
cord-270709-jahnjvyk	28	7	LSRT	LSRT	NNP
cord-270709-jahnjvyk	28	8	design	design	NN
cord-270709-jahnjvyk	28	9	are	be	VBP
cord-270709-jahnjvyk	28	10	that	that	IN
cord-270709-jahnjvyk	28	11	it	-PRON-	PRP
cord-270709-jahnjvyk	28	12	allows	allow	VBZ
cord-270709-jahnjvyk	28	13	central	central	JJ
cord-270709-jahnjvyk	28	14	randomization	randomization	NN
cord-270709-jahnjvyk	28	15	of	of	IN
cord-270709-jahnjvyk	28	16	large	large	JJ
cord-270709-jahnjvyk	28	17	numbers	number	NNS
cord-270709-jahnjvyk	28	18	of	of	IN
cord-270709-jahnjvyk	28	19	volunteers	volunteer	NNS
cord-270709-jahnjvyk	28	20	within	within	IN
cord-270709-jahnjvyk	28	21	a	a	DT
cord-270709-jahnjvyk	28	22	short	short	JJ
cord-270709-jahnjvyk	28	23	time	time	NN
cord-270709-jahnjvyk	28	24	and	and	CC
cord-270709-jahnjvyk	28	25	rapid	rapid	JJ
cord-270709-jahnjvyk	28	26	collection	collection	NN
cord-270709-jahnjvyk	28	27	of	of	IN
cord-270709-jahnjvyk	28	28	the	the	DT
cord-270709-jahnjvyk	28	29	relevant	relevant	JJ
cord-270709-jahnjvyk	28	30	outcomes	outcome	NNS
cord-270709-jahnjvyk	28	31	at	at	IN
cord-270709-jahnjvyk	28	32	a	a	DT
cord-270709-jahnjvyk	28	33	low	low	JJ
cord-270709-jahnjvyk	28	34	cost	cost	NN
cord-270709-jahnjvyk	28	35	compared	compare	VBN
cord-270709-jahnjvyk	28	36	to	to	IN
cord-270709-jahnjvyk	28	37	the	the	DT
cord-270709-jahnjvyk	28	38	conventional	conventional	JJ
cord-270709-jahnjvyk	28	39	phase	phase	NN
cord-270709-jahnjvyk	28	40	3	3	CD
cord-270709-jahnjvyk	28	41	trials	trial	NNS
cord-270709-jahnjvyk	28	42	with	with	IN
cord-270709-jahnjvyk	28	43	many	many	JJ
cord-270709-jahnjvyk	28	44	follow	follow	NN
cord-270709-jahnjvyk	28	45	-	-	HYPH
cord-270709-jahnjvyk	28	46	up	up	NN
cord-270709-jahnjvyk	28	47	visits	visit	NNS
cord-270709-jahnjvyk	28	48	and	and	CC
cord-270709-jahnjvyk	28	49	extensive	extensive	JJ
cord-270709-jahnjvyk	28	50	monitoring	monitoring	NN
cord-270709-jahnjvyk	28	51	.	.	.
cord-270709-jahnjvyk	29	1	Adaptive	adaptive	JJ
cord-270709-jahnjvyk	29	2	design	design	NN
cord-270709-jahnjvyk	29	3	features	feature	NNS
cord-270709-jahnjvyk	29	4	(	(	-LRB-
cord-270709-jahnjvyk	29	5	eg	eg	IN
cord-270709-jahnjvyk	29	6	,	,	,
cord-270709-jahnjvyk	29	7	modification	modification	NN
cord-270709-jahnjvyk	29	8	of	of	IN
cord-270709-jahnjvyk	29	9	the	the	DT
cord-270709-jahnjvyk	29	10	eligibility	eligibility	NN
cord-270709-jahnjvyk	29	11	criteria	criterion	NNS
cord-270709-jahnjvyk	29	12	considering	consider	VBG
cord-270709-jahnjvyk	29	13	the	the	DT
cord-270709-jahnjvyk	29	14	accruing	accrue	VBG
cord-270709-jahnjvyk	29	15	safety	safety	NN
cord-270709-jahnjvyk	29	16	information	information	NN
cord-270709-jahnjvyk	29	17	)	)	-RRB-
cord-270709-jahnjvyk	29	18	are	be	VBP
cord-270709-jahnjvyk	29	19	feasible	feasible	JJ
cord-270709-jahnjvyk	29	20	as	as	RB
cord-270709-jahnjvyk	29	21	well	well	RB
cord-270709-jahnjvyk	29	22	.	.	.
cord-270709-jahnjvyk	30	1	Given	give	VBN
cord-270709-jahnjvyk	30	2	the	the	DT
cord-270709-jahnjvyk	30	3	wide	wide	JJ
cord-270709-jahnjvyk	30	4	entry	entry	NN
cord-270709-jahnjvyk	30	5	criteria	criterion	NNS
cord-270709-jahnjvyk	30	6	,	,	,
cord-270709-jahnjvyk	30	7	the	the	DT
cord-270709-jahnjvyk	30	8	results	result	NNS
cord-270709-jahnjvyk	30	9	provide	provide	VBP
cord-270709-jahnjvyk	30	10	external	external	JJ
cord-270709-jahnjvyk	30	11	validity	validity	NN
cord-270709-jahnjvyk	30	12	for	for	IN
cord-270709-jahnjvyk	30	13	large	large	JJ
cord-270709-jahnjvyk	30	14	parts	part	NNS
cord-270709-jahnjvyk	30	15	of	of	IN
cord-270709-jahnjvyk	30	16	the	the	DT
cord-270709-jahnjvyk	30	17	population	population	NN
cord-270709-jahnjvyk	30	18	compared	compare	VBN
cord-270709-jahnjvyk	30	19	to	to	IN
cord-270709-jahnjvyk	30	20	any	any	DT
cord-270709-jahnjvyk	30	21	challenge	challenge	NN
cord-270709-jahnjvyk	30	22	trial	trial	NN
cord-270709-jahnjvyk	30	23	,	,	,
cord-270709-jahnjvyk	30	24	which	which	WDT
cord-270709-jahnjvyk	30	25	would	would	MD
cord-270709-jahnjvyk	30	26	need	need	VB
cord-270709-jahnjvyk	30	27	to	to	TO
cord-270709-jahnjvyk	30	28	focus	focus	VB
cord-270709-jahnjvyk	30	29	on	on	IN
cord-270709-jahnjvyk	30	30	participants	participant	NNS
cord-270709-jahnjvyk	30	31	with	with	IN
cord-270709-jahnjvyk	30	32	extremely	extremely	RB
cord-270709-jahnjvyk	30	33	low	low	JJ
cord-270709-jahnjvyk	30	34	risks	risk	NNS
cord-270709-jahnjvyk	30	35	for	for	IN
cord-270709-jahnjvyk	30	36	developing	develop	VBG
cord-270709-jahnjvyk	30	37	serious	serious	JJ
cord-270709-jahnjvyk	30	38	COVID-19	covid-19	NN
cord-270709-jahnjvyk	30	39	.	.	.
cord-270709-jahnjvyk	31	1	As	as	IN
cord-270709-jahnjvyk	31	2	there	there	EX
cord-270709-jahnjvyk	31	3	will	will	MD
cord-270709-jahnjvyk	31	4	be	be	VB
cord-270709-jahnjvyk	31	5	very	very	RB
cord-270709-jahnjvyk	31	6	many	many	JJ
cord-270709-jahnjvyk	31	7	people	people	NNS
cord-270709-jahnjvyk	31	8	who	who	WP
cord-270709-jahnjvyk	31	9	would	would	MD
cord-270709-jahnjvyk	31	10	like	like	VB
cord-270709-jahnjvyk	31	11	to	to	TO
cord-270709-jahnjvyk	31	12	participate	participate	VB
cord-270709-jahnjvyk	31	13	in	in	IN
cord-270709-jahnjvyk	31	14	such	such	PDT
cord-270709-jahnjvyk	31	15	a	a	DT
cord-270709-jahnjvyk	31	16	vaccination	vaccination	NN
cord-270709-jahnjvyk	31	17	trial	trial	NN
cord-270709-jahnjvyk	31	18	,	,	,
cord-270709-jahnjvyk	31	19	the	the	DT
cord-270709-jahnjvyk	31	20	sample	sample	NN
cord-270709-jahnjvyk	31	21	sizes	size	NNS
cord-270709-jahnjvyk	31	22	needed	need	VBN
cord-270709-jahnjvyk	31	23	should	should	MD
cord-270709-jahnjvyk	31	24	be	be	VB
cord-270709-jahnjvyk	31	25	achieved	achieve	VBN
cord-270709-jahnjvyk	31	26	within	within	IN
cord-270709-jahnjvyk	31	27	a	a	DT
cord-270709-jahnjvyk	31	28	very	very	RB
cord-270709-jahnjvyk	31	29	short	short	JJ
cord-270709-jahnjvyk	31	30	time	time	NN
cord-270709-jahnjvyk	31	31	.	.	.
cord-270709-jahnjvyk	32	1	When	when	WRB
cord-270709-jahnjvyk	32	2	the	the	DT
cord-270709-jahnjvyk	32	3	LSRT	lsrt	NN
cord-270709-jahnjvyk	32	4	double	double	JJ
cord-270709-jahnjvyk	32	5	-	-	HYPH
cord-270709-jahnjvyk	32	6	blind	blind	JJ
cord-270709-jahnjvyk	32	7	design	design	NN
cord-270709-jahnjvyk	32	8	is	be	VBZ
cord-270709-jahnjvyk	32	9	used	use	VBN
cord-270709-jahnjvyk	32	10	,	,	,
cord-270709-jahnjvyk	32	11	the	the	DT
cord-270709-jahnjvyk	32	12	validity	validity	NN
cord-270709-jahnjvyk	32	13	of	of	IN
cord-270709-jahnjvyk	32	14	the	the	DT
cord-270709-jahnjvyk	32	15	results	result	NNS
cord-270709-jahnjvyk	32	16	is	be	VBZ
cord-270709-jahnjvyk	32	17	assured	assure	VBN
cord-270709-jahnjvyk	32	18	and	and	CC
cord-270709-jahnjvyk	32	19	it	-PRON-	PRP
cord-270709-jahnjvyk	32	20	does	do	VBZ
cord-270709-jahnjvyk	32	21	not	not	RB
cord-270709-jahnjvyk	32	22	generate	generate	VB
cord-270709-jahnjvyk	32	23	the	the	DT
cord-270709-jahnjvyk	32	24	serious	serious	JJ
cord-270709-jahnjvyk	32	25	ethical	ethical	JJ
cord-270709-jahnjvyk	32	26	issues	issue	NNS
cord-270709-jahnjvyk	32	27	inherent	inherent	JJ
cord-270709-jahnjvyk	32	28	in	in	IN
cord-270709-jahnjvyk	32	29	challenge	challenge	NN
cord-270709-jahnjvyk	32	30	trials	trial	NNS
cord-270709-jahnjvyk	32	31	.	.	.
cord-270709-jahnjvyk	33	1	Regarding	regard	VBG
cord-270709-jahnjvyk	33	2	the	the	DT
cord-270709-jahnjvyk	33	3	Salk	Salk	NNP
cord-270709-jahnjvyk	33	4	vaccine	vaccine	NN
cord-270709-jahnjvyk	33	5	,	,	,
cord-270709-jahnjvyk	33	6	large	large	JJ
cord-270709-jahnjvyk	33	7	randomized	randomized	JJ
cord-270709-jahnjvyk	33	8	trials	trial	NNS
cord-270709-jahnjvyk	33	9	with	with	IN
cord-270709-jahnjvyk	33	10	sample	sample	NN
cord-270709-jahnjvyk	33	11	sizes	size	NNS
cord-270709-jahnjvyk	33	12	of	of	IN
cord-270709-jahnjvyk	33	13	more	more	JJR
cord-270709-jahnjvyk	33	14	than	than	IN
cord-270709-jahnjvyk	33	15	70	70	CD
cord-270709-jahnjvyk	33	16	000	000	CD
cord-270709-jahnjvyk	33	17	were	be	VBD
cord-270709-jahnjvyk	33	18	done	do	VBN
cord-270709-jahnjvyk	33	19	in	in	IN
cord-270709-jahnjvyk	33	20	the	the	DT
cord-270709-jahnjvyk	33	21	early	early	JJ
cord-270709-jahnjvyk	33	22	1950s	1950	NNS
cord-270709-jahnjvyk	33	23	[	[	-LRB-
cord-270709-jahnjvyk	33	24	10	10	CD
cord-270709-jahnjvyk	33	25	]	]	-RRB-
cord-270709-jahnjvyk	33	26	and	and	CC
cord-270709-jahnjvyk	33	27	such	such	JJ
cord-270709-jahnjvyk	33	28	LSRTs	lsrt	NNS
cord-270709-jahnjvyk	33	29	should	should	MD
cord-270709-jahnjvyk	33	30	be	be	VB
cord-270709-jahnjvyk	33	31	feasible	feasible	JJ
cord-270709-jahnjvyk	33	32	in	in	IN
cord-270709-jahnjvyk	33	33	2020	2020	CD
cord-270709-jahnjvyk	33	34	.	.	.
cord-270709-jahnjvyk	34	1	Thus	thus	RB
cord-270709-jahnjvyk	34	2	,	,	,
cord-270709-jahnjvyk	34	3	the	the	DT
cord-270709-jahnjvyk	34	4	sponsors	sponsor	NNS
cord-270709-jahnjvyk	34	5	of	of	IN
cord-270709-jahnjvyk	34	6	vaccine	vaccine	NN
cord-270709-jahnjvyk	34	7	trials	trial	NNS
cord-270709-jahnjvyk	34	8	and	and	CC
cord-270709-jahnjvyk	34	9	the	the	DT
cord-270709-jahnjvyk	34	10	drug	drug	NN
cord-270709-jahnjvyk	34	11	regulatory	regulatory	JJ
cord-270709-jahnjvyk	34	12	agencies	agency	NNS
cord-270709-jahnjvyk	34	13	should	should	MD
cord-270709-jahnjvyk	34	14	start	start	VB
cord-270709-jahnjvyk	34	15	the	the	DT
cord-270709-jahnjvyk	34	16	preparatory	preparatory	JJ
cord-270709-jahnjvyk	34	17	work	work	NN
cord-270709-jahnjvyk	34	18	now	now	RB
cord-270709-jahnjvyk	34	19	to	to	TO
cord-270709-jahnjvyk	34	20	be	be	VB
cord-270709-jahnjvyk	34	21	ready	ready	JJ
cord-270709-jahnjvyk	34	22	once	once	IN
cord-270709-jahnjvyk	34	23	an	an	DT
cord-270709-jahnjvyk	34	24	investigational	investigational	JJ
cord-270709-jahnjvyk	34	25	vaccine	vaccine	NN
cord-270709-jahnjvyk	34	26	is	be	VBZ
cord-270709-jahnjvyk	34	27	ready	ready	JJ
cord-270709-jahnjvyk	34	28	to	to	TO
cord-270709-jahnjvyk	34	29	be	be	VB
cord-270709-jahnjvyk	34	30	administered	administer	VBN
cord-270709-jahnjvyk	34	31	on	on	IN
cord-270709-jahnjvyk	34	32	a	a	DT
cord-270709-jahnjvyk	34	33	large	large	JJ
cord-270709-jahnjvyk	34	34	scale	scale	NN
cord-270709-jahnjvyk	34	35	.	.	.
cord-270709-jahnjvyk	35	1	Disclaimer	disclaimer	NN
cord-270709-jahnjvyk	35	2	.	.	.
cord-270709-jahnjvyk	36	1	The	the	DT
cord-270709-jahnjvyk	36	2	opinions	opinion	NNS
cord-270709-jahnjvyk	36	3	expressed	express	VBN
cord-270709-jahnjvyk	36	4	do	do	VBP
cord-270709-jahnjvyk	36	5	not	not	RB
cord-270709-jahnjvyk	36	6	necessarily	necessarily	RB
cord-270709-jahnjvyk	36	7	represent	represent	VB
cord-270709-jahnjvyk	36	8	those	those	DT
cord-270709-jahnjvyk	36	9	of	of	IN
cord-270709-jahnjvyk	36	10	the	the	DT
cord-270709-jahnjvyk	36	11	Association	Association	NNP
cord-270709-jahnjvyk	36	12	of	of	IN
cord-270709-jahnjvyk	36	13	Medical	Medical	NNP
cord-270709-jahnjvyk	36	14	Ethics	Ethics	NNP
cord-270709-jahnjvyk	36	15	Committees	Committees	NNPS
cord-270709-jahnjvyk	36	16	in	in	IN
cord-270709-jahnjvyk	36	17	Germany	Germany	NNP
cord-270709-jahnjvyk	36	18	.	.	.
cord-270709-jahnjvyk	37	1	Potential	potential	JJ
cord-270709-jahnjvyk	37	2	conflicts	conflict	NNS
cord-270709-jahnjvyk	37	3	of	of	IN
cord-270709-jahnjvyk	37	4	interest	interest	NN
cord-270709-jahnjvyk	37	5	.	.	.
cord-270709-jahnjvyk	38	1	Author	author	NN
cord-270709-jahnjvyk	38	2	certifies	certify	VBZ
cord-270709-jahnjvyk	38	3	no	no	DT
cord-270709-jahnjvyk	38	4	potential	potential	JJ
cord-270709-jahnjvyk	38	5	conflicts	conflict	NNS
cord-270709-jahnjvyk	38	6	of	of	IN
cord-270709-jahnjvyk	38	7	interest	interest	NN
cord-270709-jahnjvyk	38	8	.	.	.
cord-270709-jahnjvyk	39	1	The	the	DT
cord-270709-jahnjvyk	39	2	author	author	NN
cord-270709-jahnjvyk	39	3	has	have	VBZ
cord-270709-jahnjvyk	39	4	submitted	submit	VBN
cord-270709-jahnjvyk	39	5	the	the	DT
cord-270709-jahnjvyk	39	6	ICMJE	ICMJE	NNP
cord-270709-jahnjvyk	39	7	Form	Form	NNP
cord-270709-jahnjvyk	39	8	for	for	IN
cord-270709-jahnjvyk	39	9	Disclosure	Disclosure	NNP
cord-270709-jahnjvyk	39	10	of	of	IN
cord-270709-jahnjvyk	39	11	Potential	Potential	NNP
cord-270709-jahnjvyk	39	12	Human	Human	NNP
cord-270709-jahnjvyk	39	13	challenge	challenge	NN
cord-270709-jahnjvyk	39	14	studies	study	NNS
cord-270709-jahnjvyk	39	15	to	to	TO
cord-270709-jahnjvyk	39	16	accelerate	accelerate	VB
cord-270709-jahnjvyk	39	17	coronavirus	coronavirus	NN
cord-270709-jahnjvyk	39	18	vaccine	vaccine	NN
cord-270709-jahnjvyk	39	19	licensure	licensure	NN
cord-270709-jahnjvyk	39	20	COVID-19	COVID-19	NNP
cord-270709-jahnjvyk	39	21	human	human	JJ
cord-270709-jahnjvyk	39	22	challenge	challenge	NN
cord-270709-jahnjvyk	39	23	trials	trial	NNS
cord-270709-jahnjvyk	40	1	Experimental	experimental	JJ
cord-270709-jahnjvyk	40	2	infections	infection	NNS
cord-270709-jahnjvyk	40	3	in	in	IN
cord-270709-jahnjvyk	40	4	humans	human	NNS
cord-270709-jahnjvyk	40	5	-	-	:
cord-270709-jahnjvyk	40	6	historical	historical	JJ
cord-270709-jahnjvyk	40	7	and	and	CC
cord-270709-jahnjvyk	40	8	ethical	ethical	JJ
cord-270709-jahnjvyk	40	9	reflections	reflection	NNS
cord-270709-jahnjvyk	41	1	Vaccines	vaccine	NNS
cord-270709-jahnjvyk	41	2	to	to	TO
cord-270709-jahnjvyk	41	3	prevent	prevent	VB
cord-270709-jahnjvyk	41	4	infectious	infectious	JJ
cord-270709-jahnjvyk	41	5	diseases	disease	NNS
cord-270709-jahnjvyk	41	6	in	in	IN
cord-270709-jahnjvyk	41	7	the	the	DT
cord-270709-jahnjvyk	41	8	older	old	JJR
cord-270709-jahnjvyk	41	9	population	population	NN
cord-270709-jahnjvyk	41	10	:	:	:
cord-270709-jahnjvyk	41	11	immunological	immunological	JJ
cord-270709-jahnjvyk	41	12	challenges	challenge	NNS
cord-270709-jahnjvyk	41	13	and	and	CC
cord-270709-jahnjvyk	41	14	future	future	JJ
cord-270709-jahnjvyk	41	15	perspectives	perspective	NNS
cord-270709-jahnjvyk	42	1	Why	why	WRB
cord-270709-jahnjvyk	42	2	do	do	VBP
cord-270709-jahnjvyk	42	3	we	-PRON-	PRP
cord-270709-jahnjvyk	42	4	need	need	VB
cord-270709-jahnjvyk	42	5	some	some	DT
cord-270709-jahnjvyk	42	6	large	large	JJ
cord-270709-jahnjvyk	42	7	,	,	,
cord-270709-jahnjvyk	42	8	simple	simple	JJ
cord-270709-jahnjvyk	42	9	randomized	randomized	JJ
cord-270709-jahnjvyk	42	10	trials	trial	NNS
cord-270709-jahnjvyk	42	11	ISIS-3	ISIS-3	NNP
cord-270709-jahnjvyk	42	12	:	:	:
cord-270709-jahnjvyk	42	13	a	a	DT
cord-270709-jahnjvyk	42	14	randomised	randomised	JJ
cord-270709-jahnjvyk	42	15	comparison	comparison	NN
cord-270709-jahnjvyk	42	16	of	of	IN
cord-270709-jahnjvyk	42	17	streptokinase	streptokinase	NNP
cord-270709-jahnjvyk	42	18	vs	vs	IN
cord-270709-jahnjvyk	42	19	tissue	tissue	NN
cord-270709-jahnjvyk	42	20	plasminogen	plasminogen	NN
cord-270709-jahnjvyk	42	21	activator	activator	NN
cord-270709-jahnjvyk	42	22	vs	vs	IN
cord-270709-jahnjvyk	42	23	anistreplase	anistreplase	NNP
cord-270709-jahnjvyk	42	24	and	and	CC
cord-270709-jahnjvyk	42	25	of	of	IN
cord-270709-jahnjvyk	42	26	aspirin	aspirin	NN
cord-270709-jahnjvyk	42	27	plus	plus	CC
cord-270709-jahnjvyk	42	28	heparin	heparin	NN
cord-270709-jahnjvyk	42	29	vs	vs	IN
cord-270709-jahnjvyk	42	30	aspirin	aspirin	NN
cord-270709-jahnjvyk	42	31	alone	alone	JJ
cord-270709-jahnjvyk	42	32	among	among	IN
cord-270709-jahnjvyk	42	33	41,299	41,299	CD
cord-270709-jahnjvyk	42	34	cases	case	NNS
cord-270709-jahnjvyk	42	35	of	of	IN
cord-270709-jahnjvyk	42	36	suspected	suspect	VBN
cord-270709-jahnjvyk	42	37	acute	acute	JJ
cord-270709-jahnjvyk	42	38	myocardial	myocardial	JJ
cord-270709-jahnjvyk	42	39	infarction	infarction	NNP
cord-270709-jahnjvyk	42	40	Vaccine	Vaccine	NNP
cord-270709-jahnjvyk	42	41	safety	safety	NN
cord-270709-jahnjvyk	42	42	datalink	datalink	NN
cord-270709-jahnjvyk	42	43	Patent	patent	NN
cord-270709-jahnjvyk	42	44	safety	safety	NN
cord-270709-jahnjvyk	42	45	Making	make	VBG
cord-270709-jahnjvyk	42	46	history	history	NN
cord-270709-jahnjvyk	42	47	:	:	:
cord-270709-jahnjvyk	42	48	Thomas	Thomas	NNP
cord-270709-jahnjvyk	42	49	Francis	Francis	NNP
cord-270709-jahnjvyk	42	50	,	,	,
cord-270709-jahnjvyk	42	51	Jr	Jr	NNP
cord-270709-jahnjvyk	42	52	,	,	,
cord-270709-jahnjvyk	42	53	MD	MD	NNP
cord-270709-jahnjvyk	42	54	,	,	,
cord-270709-jahnjvyk	42	55	and	and	CC
cord-270709-jahnjvyk	42	56	the	the	DT
cord-270709-jahnjvyk	42	57	1954	1954	CD
cord-270709-jahnjvyk	42	58	Salk	Salk	NNP
cord-270709-jahnjvyk	42	59	poliomyelitis	poliomyelitis	NN
cord-270709-jahnjvyk	42	60	vaccine	vaccine	NN
cord-270709-jahnjvyk	42	61	field	field	NN
cord-270709-jahnjvyk	42	62	trial	trial	NN