id sid tid token lemma pos cord-007277-86lynlxn 1 1 key key JJ cord-007277-86lynlxn 1 2 : : : cord-007277-86lynlxn 1 3 cord-007277 cord-007277 NN cord-007277-86lynlxn 1 4 - - HYPH cord-007277-86lynlxn 1 5 86lynlxn 86lynlxn CD cord-007277-86lynlxn 1 6 authors author NNS cord-007277-86lynlxn 1 7 : : : cord-007277-86lynlxn 1 8 Kenneth Kenneth NNP cord-007277-86lynlxn 1 9 , , , cord-007277-86lynlxn 1 10 McIntosh McIntosh NNP cord-007277-86lynlxn 1 11 title title NN cord-007277-86lynlxn 1 12 : : : cord-007277-86lynlxn 1 13 Coronaviruses coronaviruse NNS cord-007277-86lynlxn 1 14 in in IN cord-007277-86lynlxn 1 15 the the DT cord-007277-86lynlxn 1 16 Limelight Limelight NNP cord-007277-86lynlxn 1 17 date date NN cord-007277-86lynlxn 1 18 : : : cord-007277-86lynlxn 1 19 2005 2005 CD cord-007277-86lynlxn 1 20 - - HYPH cord-007277-86lynlxn 1 21 02 02 CD cord-007277-86lynlxn 1 22 - - SYM cord-007277-86lynlxn 1 23 15 15 CD cord-007277-86lynlxn 1 24 journal journal NN cord-007277-86lynlxn 1 25 : : : cord-007277-86lynlxn 2 1 J J NNP cord-007277-86lynlxn 2 2 Infect infect VBP cord-007277-86lynlxn 2 3 Dis Dis NNP cord-007277-86lynlxn 2 4 DOI doi NN cord-007277-86lynlxn 2 5 : : : cord-007277-86lynlxn 2 6 10.1086/428510 10.1086/428510 CD cord-007277-86lynlxn 2 7 sha sha NNP cord-007277-86lynlxn 2 8 : : : cord-007277-86lynlxn 2 9 eac9728835f6d166373381ea78ae11525323bfa2 eac9728835f6d166373381ea78ae11525323bfa2 NNP cord-007277-86lynlxn 2 10 doc_id doc_id NNP cord-007277-86lynlxn 2 11 : : : cord-007277-86lynlxn 2 12 7277 7277 CD cord-007277-86lynlxn 2 13 cord_uid cord_uid NNS cord-007277-86lynlxn 2 14 : : : cord-007277-86lynlxn 3 1 86lynlxn 86lynlxn CC cord-007277-86lynlxn 3 2 nan nan NNP cord-007277-86lynlxn 4 1 For for IN cord-007277-86lynlxn 4 2 ∼35 ∼35 NN cord-007277-86lynlxn 4 3 years year NNS cord-007277-86lynlxn 4 4 after after IN cord-007277-86lynlxn 4 5 their -PRON- PRP$ cord-007277-86lynlxn 4 6 first first JJ cord-007277-86lynlxn 4 7 description description NN cord-007277-86lynlxn 4 8 by by IN cord-007277-86lynlxn 4 9 Tyrrell Tyrrell NNP cord-007277-86lynlxn 4 10 and and CC cord-007277-86lynlxn 4 11 Byneo Byneo NNP cord-007277-86lynlxn 4 12 in in IN cord-007277-86lynlxn 4 13 1965 1965 CD cord-007277-86lynlxn 4 14 [ [ -LRB- cord-007277-86lynlxn 4 15 1 1 CD cord-007277-86lynlxn 4 16 ] ] -RRB- cord-007277-86lynlxn 4 17 , , , cord-007277-86lynlxn 4 18 the the DT cord-007277-86lynlxn 4 19 field field NN cord-007277-86lynlxn 4 20 of of IN cord-007277-86lynlxn 4 21 human human JJ cord-007277-86lynlxn 4 22 coronaviruses coronaviruse NNS cord-007277-86lynlxn 4 23 ( ( -LRB- cord-007277-86lynlxn 4 24 HCoVs HCoVs NNP cord-007277-86lynlxn 4 25 ) ) -RRB- cord-007277-86lynlxn 4 26 was be VBD cord-007277-86lynlxn 4 27 pretty pretty RB cord-007277-86lynlxn 4 28 dull dull JJ cord-007277-86lynlxn 4 29 . . . cord-007277-86lynlxn 5 1 There there EX cord-007277-86lynlxn 5 2 were be VBD cord-007277-86lynlxn 5 3 classic classic JJ cord-007277-86lynlxn 5 4 early early JJ cord-007277-86lynlxn 5 5 descriptions description NNS cord-007277-86lynlxn 5 6 of of IN cord-007277-86lynlxn 5 7 their -PRON- PRP$ cord-007277-86lynlxn 5 8 respiratory respiratory JJ cord-007277-86lynlxn 5 9 pathogenicity pathogenicity NN cord-007277-86lynlxn 5 10 in in IN cord-007277-86lynlxn 5 11 volunteer volunteer NN cord-007277-86lynlxn 5 12 studies study NNS cord-007277-86lynlxn 5 13 [ [ -LRB- cord-007277-86lynlxn 5 14 2 2 CD cord-007277-86lynlxn 5 15 , , , cord-007277-86lynlxn 5 16 3 3 CD cord-007277-86lynlxn 5 17 ] ] -RRB- cord-007277-86lynlxn 5 18 , , , cord-007277-86lynlxn 5 19 and and CC cord-007277-86lynlxn 5 20 there there EX cord-007277-86lynlxn 5 21 were be VBD cord-007277-86lynlxn 5 22 seroepidemiologic seroepidemiologic JJ cord-007277-86lynlxn 5 23 studies study NNS cord-007277-86lynlxn 5 24 of of IN cord-007277-86lynlxn 5 25 the the DT cord-007277-86lynlxn 5 26 2 2 CD cord-007277-86lynlxn 5 27 most most RBS cord-007277-86lynlxn 5 28 easily easily RB cord-007277-86lynlxn 5 29 studied study VBD cord-007277-86lynlxn 5 30 strains strain NNS cord-007277-86lynlxn 5 31 , , , cord-007277-86lynlxn 5 32 HCoV-229E HCoV-229E NNP cord-007277-86lynlxn 5 33 and and CC cord-007277-86lynlxn 5 34 HCoV HCoV NNP cord-007277-86lynlxn 5 35 - - HYPH cord-007277-86lynlxn 5 36 OC43 OC43 NNP cord-007277-86lynlxn 5 37 [ [ -LRB- cord-007277-86lynlxn 5 38 4 4 CD cord-007277-86lynlxn 5 39 ] ] -RRB- cord-007277-86lynlxn 6 1 [ [ -LRB- cord-007277-86lynlxn 6 2 5 5 CD cord-007277-86lynlxn 6 3 ] ] -RRB- cord-007277-86lynlxn 6 4 [ [ -LRB- cord-007277-86lynlxn 6 5 6 6 CD cord-007277-86lynlxn 6 6 ] ] -RRB- cord-007277-86lynlxn 6 7 . . . cord-007277-86lynlxn 7 1 Efforts effort NNS cord-007277-86lynlxn 7 2 to to TO cord-007277-86lynlxn 7 3 implicate implicate VB cord-007277-86lynlxn 7 4 HCoVs hcovs NN cord-007277-86lynlxn 7 5 in in IN cord-007277-86lynlxn 7 6 diseases disease NNS cord-007277-86lynlxn 7 7 of of IN cord-007277-86lynlxn 7 8 the the DT cord-007277-86lynlxn 7 9 gastrointestinal gastrointestinal JJ cord-007277-86lynlxn 7 10 tract tract NN cord-007277-86lynlxn 7 11 were be VBD cord-007277-86lynlxn 7 12 largely largely RB cord-007277-86lynlxn 7 13 unsuccessful unsuccessful JJ cord-007277-86lynlxn 7 14 , , , cord-007277-86lynlxn 7 15 with with IN cord-007277-86lynlxn 7 16 the the DT cord-007277-86lynlxn 7 17 possible possible JJ cord-007277-86lynlxn 7 18 exception exception NN cord-007277-86lynlxn 7 19 of of IN cord-007277-86lynlxn 7 20 a a DT cord-007277-86lynlxn 7 21 postulated postulate VBN cord-007277-86lynlxn 7 22 role role NN cord-007277-86lynlxn 7 23 in in IN cord-007277-86lynlxn 7 24 necrotizing necrotize VBG cord-007277-86lynlxn 7 25 enterocolitis enterocolitis NN cord-007277-86lynlxn 7 26 of of IN cord-007277-86lynlxn 7 27 newborns newborn NNS cord-007277-86lynlxn 7 28 [ [ -LRB- cord-007277-86lynlxn 7 29 7 7 CD cord-007277-86lynlxn 7 30 ] ] -RRB- cord-007277-86lynlxn 7 31 . . . cord-007277-86lynlxn 8 1 During during IN cord-007277-86lynlxn 8 2 this this DT cord-007277-86lynlxn 8 3 time time NN cord-007277-86lynlxn 8 4 , , , cord-007277-86lynlxn 8 5 the the DT cord-007277-86lynlxn 8 6 fields field NNS cord-007277-86lynlxn 8 7 of of IN cord-007277-86lynlxn 8 8 animal animal NN cord-007277-86lynlxn 8 9 CoVs covs NN cord-007277-86lynlxn 8 10 and and CC cord-007277-86lynlxn 8 11 of of IN cord-007277-86lynlxn 8 12 the the DT cord-007277-86lynlxn 8 13 molecular molecular JJ cord-007277-86lynlxn 8 14 biology biology NN cord-007277-86lynlxn 8 15 of of IN cord-007277-86lynlxn 8 16 CoVs CoVs NNP cord-007277-86lynlxn 8 17 were be VBD cord-007277-86lynlxn 8 18 , , , cord-007277-86lynlxn 8 19 in in IN cord-007277-86lynlxn 8 20 contrast contrast NN cord-007277-86lynlxn 8 21 , , , cord-007277-86lynlxn 8 22 buzzing buzz VBG cord-007277-86lynlxn 8 23 . . . cord-007277-86lynlxn 9 1 CoVs CoVs NNP cord-007277-86lynlxn 9 2 were be VBD cord-007277-86lynlxn 9 3 discovered discover VBN cord-007277-86lynlxn 9 4 in in IN cord-007277-86lynlxn 9 5 large large JJ cord-007277-86lynlxn 9 6 numbers number NNS cord-007277-86lynlxn 9 7 and and CC cord-007277-86lynlxn 9 8 were be VBD cord-007277-86lynlxn 9 9 implicated implicate VBN cord-007277-86lynlxn 9 10 in in IN cord-007277-86lynlxn 9 11 a a DT cord-007277-86lynlxn 9 12 rich rich JJ cord-007277-86lynlxn 9 13 variety variety NN cord-007277-86lynlxn 9 14 of of IN cord-007277-86lynlxn 9 15 animal animal NN cord-007277-86lynlxn 9 16 diseases disease NNS cord-007277-86lynlxn 9 17 in in IN cord-007277-86lynlxn 9 18 multiple multiple JJ cord-007277-86lynlxn 9 19 species specie NNS cord-007277-86lynlxn 9 20 . . . cord-007277-86lynlxn 10 1 Diseases disease NNS cord-007277-86lynlxn 10 2 as as IN cord-007277-86lynlxn 10 3 widely widely RB cord-007277-86lynlxn 10 4 varying vary VBG cord-007277-86lynlxn 10 5 as as IN cord-007277-86lynlxn 10 6 progressive progressive JJ cord-007277-86lynlxn 10 7 peritonitis peritonitis NN cord-007277-86lynlxn 10 8 , , , cord-007277-86lynlxn 10 9 nephritis nephritis NN cord-007277-86lynlxn 10 10 , , , cord-007277-86lynlxn 10 11 acute acute JJ cord-007277-86lynlxn 10 12 and and CC cord-007277-86lynlxn 10 13 chronic chronic JJ cord-007277-86lynlxn 10 14 hepatitis hepatitis NN cord-007277-86lynlxn 10 15 , , , cord-007277-86lynlxn 10 16 and and CC cord-007277-86lynlxn 10 17 subacute subacute JJ cord-007277-86lynlxn 10 18 encephalitis encephaliti NNS cord-007277-86lynlxn 10 19 were be VBD cord-007277-86lynlxn 10 20 described describe VBN cord-007277-86lynlxn 10 21 , , , cord-007277-86lynlxn 10 22 along along IN cord-007277-86lynlxn 10 23 with with IN cord-007277-86lynlxn 10 24 the the DT cord-007277-86lynlxn 10 25 more more RBR cord-007277-86lynlxn 10 26 traditional traditional JJ cord-007277-86lynlxn 10 27 respiratory respiratory JJ cord-007277-86lynlxn 10 28 and and CC cord-007277-86lynlxn 10 29 gastrointestinal gastrointestinal JJ cord-007277-86lynlxn 10 30 syndromes syndrome NNS cord-007277-86lynlxn 10 31 , , , cord-007277-86lynlxn 10 32 and and CC cord-007277-86lynlxn 10 33 pathogenesis pathogenesis NN cord-007277-86lynlxn 10 34 was be VBD cord-007277-86lynlxn 10 35 explained explain VBN cord-007277-86lynlxn 10 36 through through IN cord-007277-86lynlxn 10 37 broad broad JJ cord-007277-86lynlxn 10 38 mixtures mixture NNS cord-007277-86lynlxn 10 39 of of IN cord-007277-86lynlxn 10 40 viral viral JJ cord-007277-86lynlxn 10 41 cytopathogenicity cytopathogenicity NN cord-007277-86lynlxn 10 42 , , , cord-007277-86lynlxn 10 43 immunologic immunologic JJ cord-007277-86lynlxn 10 44 damage damage NN cord-007277-86lynlxn 10 45 , , , cord-007277-86lynlxn 10 46 and and CC cord-007277-86lynlxn 10 47 genetic genetic JJ cord-007277-86lynlxn 10 48 susceptibilities susceptibility NNS cord-007277-86lynlxn 10 49 . . . cord-007277-86lynlxn 11 1 The the DT cord-007277-86lynlxn 11 2 CoV cov NN cord-007277-86lynlxn 11 3 genome genome NN cord-007277-86lynlxn 11 4 proved prove VBD cord-007277-86lynlxn 11 5 to to TO cord-007277-86lynlxn 11 6 be be VB cord-007277-86lynlxn 11 7 the the DT cord-007277-86lynlxn 11 8 largest large JJS cord-007277-86lynlxn 11 9 of of IN cord-007277-86lynlxn 11 10 all all DT cord-007277-86lynlxn 11 11 of of IN cord-007277-86lynlxn 11 12 the the DT cord-007277-86lynlxn 11 13 RNA RNA NNP cord-007277-86lynlxn 11 14 viruses virus NNS cord-007277-86lynlxn 11 15 and and CC cord-007277-86lynlxn 11 16 to to TO cord-007277-86lynlxn 11 17 have have VB cord-007277-86lynlxn 11 18 a a DT cord-007277-86lynlxn 11 19 unique unique JJ cord-007277-86lynlxn 11 20 strategy strategy NN cord-007277-86lynlxn 11 21 of of IN cord-007277-86lynlxn 11 22 replication replication NN cord-007277-86lynlxn 11 23 , , , cord-007277-86lynlxn 11 24 with with IN cord-007277-86lynlxn 11 25 transcription transcription NN cord-007277-86lynlxn 11 26 and and CC cord-007277-86lynlxn 11 27 protein protein NN cord-007277-86lynlxn 11 28 production production NN cord-007277-86lynlxn 11 29 occurring occur VBG cord-007277-86lynlxn 11 30 through through IN cord-007277-86lynlxn 11 31 a a DT cord-007277-86lynlxn 11 32 nested nest VBN cord-007277-86lynlxn 11 33 set set NN cord-007277-86lynlxn 11 34 of of IN cord-007277-86lynlxn 11 35 mRNA mrna NN cord-007277-86lynlxn 11 36 molecules molecule NNS cord-007277-86lynlxn 11 37 [ [ -LRB- cord-007277-86lynlxn 11 38 8 8 CD cord-007277-86lynlxn 11 39 ] ] -RRB- cord-007277-86lynlxn 11 40 . . . cord-007277-86lynlxn 12 1 Then then RB cord-007277-86lynlxn 12 2 , , , cord-007277-86lynlxn 12 3 in in IN cord-007277-86lynlxn 12 4 2003 2003 CD cord-007277-86lynlxn 12 5 , , , cord-007277-86lynlxn 12 6 the the DT cord-007277-86lynlxn 12 7 appearance appearance NN cord-007277-86lynlxn 12 8 of of IN cord-007277-86lynlxn 12 9 severe severe JJ cord-007277-86lynlxn 12 10 acute acute JJ cord-007277-86lynlxn 12 11 respiratory respiratory JJ cord-007277-86lynlxn 12 12 syndrome syndrome NN cord-007277-86lynlxn 12 13 ( ( -LRB- cord-007277-86lynlxn 12 14 SARS SARS NNP cord-007277-86lynlxn 12 15 ) ) -RRB- cord-007277-86lynlxn 12 16 suddenly suddenly RB cord-007277-86lynlxn 12 17 brought bring VBD cord-007277-86lynlxn 12 18 the the DT cord-007277-86lynlxn 12 19 field field NN cord-007277-86lynlxn 12 20 of of IN cord-007277-86lynlxn 12 21 HCoVs HCoVs NNP cord-007277-86lynlxn 12 22 back back RB cord-007277-86lynlxn 12 23 into into IN cord-007277-86lynlxn 12 24 the the DT cord-007277-86lynlxn 12 25 limelight limelight NN cord-007277-86lynlxn 12 26 . . . cord-007277-86lynlxn 13 1 It -PRON- PRP cord-007277-86lynlxn 13 2 seemed seem VBD cord-007277-86lynlxn 13 3 clear clear JJ cord-007277-86lynlxn 13 4 that that IN cord-007277-86lynlxn 13 5 this this DT cord-007277-86lynlxn 13 6 disease disease NN cord-007277-86lynlxn 13 7 , , , cord-007277-86lynlxn 13 8 unique unique JJ cord-007277-86lynlxn 13 9 in in IN cord-007277-86lynlxn 13 10 its -PRON- PRP$ cord-007277-86lynlxn 13 11 clinical clinical JJ cord-007277-86lynlxn 13 12 spectrum spectrum NN cord-007277-86lynlxn 13 13 , , , cord-007277-86lynlxn 13 14 resulted result VBD cord-007277-86lynlxn 13 15 from from IN cord-007277-86lynlxn 13 16 the the DT cord-007277-86lynlxn 13 17 movement movement NN cord-007277-86lynlxn 13 18 of of IN cord-007277-86lynlxn 13 19 an an DT cord-007277-86lynlxn 13 20 animal animal NN cord-007277-86lynlxn 13 21 CoV cov NN cord-007277-86lynlxn 13 22 across across IN cord-007277-86lynlxn 13 23 species species NN cord-007277-86lynlxn 13 24 lines line NNS cord-007277-86lynlxn 13 25 , , , cord-007277-86lynlxn 13 26 and and CC cord-007277-86lynlxn 13 27 it -PRON- PRP cord-007277-86lynlxn 13 28 seemed seem VBD cord-007277-86lynlxn 13 29 possible possible JJ cord-007277-86lynlxn 13 30 that that IN cord-007277-86lynlxn 13 31 the the DT cord-007277-86lynlxn 13 32 virus virus NN cord-007277-86lynlxn 13 33 spread spread VBD cord-007277-86lynlxn 13 34 in in IN cord-007277-86lynlxn 13 35 the the DT cord-007277-86lynlxn 13 36 human human JJ cord-007277-86lynlxn 13 37 population population NN cord-007277-86lynlxn 13 38 through through IN cord-007277-86lynlxn 13 39 a a DT cord-007277-86lynlxn 13 40 process process NN cord-007277-86lynlxn 13 41 of of IN cord-007277-86lynlxn 13 42 adaptation adaptation NN cord-007277-86lynlxn 13 43 by by IN cord-007277-86lynlxn 13 44 deletion deletion NN cord-007277-86lynlxn 13 45 and and CC cord-007277-86lynlxn 13 46 mutation mutation NN cord-007277-86lynlxn 13 47 [ [ -LRB- cord-007277-86lynlxn 13 48 9 9 CD cord-007277-86lynlxn 13 49 , , , cord-007277-86lynlxn 13 50 10 10 CD cord-007277-86lynlxn 13 51 ] ] -RRB- cord-007277-86lynlxn 13 52 . . . cord-007277-86lynlxn 14 1 The the DT cord-007277-86lynlxn 14 2 rapid rapid JJ cord-007277-86lynlxn 14 3 recognition recognition NN cord-007277-86lynlxn 14 4 of of IN cord-007277-86lynlxn 14 5 the the DT cord-007277-86lynlxn 14 6 etiology etiology NN cord-007277-86lynlxn 14 7 of of IN cord-007277-86lynlxn 14 8 SARS SARS NNP cord-007277-86lynlxn 14 9 depended depend VBD cord-007277-86lynlxn 14 10 heavily heavily RB cord-007277-86lynlxn 14 11 on on IN cord-007277-86lynlxn 14 12 genomic genomic JJ cord-007277-86lynlxn 14 13 sequence sequence NN cord-007277-86lynlxn 14 14 data datum NNS cord-007277-86lynlxn 14 15 assembled assemble VBN cord-007277-86lynlxn 14 16 from from IN cord-007277-86lynlxn 14 17 the the DT cord-007277-86lynlxn 14 18 study study NN cord-007277-86lynlxn 14 19 of of IN cord-007277-86lynlxn 14 20 multiple multiple JJ cord-007277-86lynlxn 14 21 animal animal NN cord-007277-86lynlxn 14 22 CoVs CoVs NNP cord-007277-86lynlxn 14 23 , , , cord-007277-86lynlxn 14 24 allowing allow VBG cord-007277-86lynlxn 14 25 the the DT cord-007277-86lynlxn 14 26 SARS SARS NNP cord-007277-86lynlxn 14 27 agent agent NN cord-007277-86lynlxn 14 28 to to TO cord-007277-86lynlxn 14 29 be be VB cord-007277-86lynlxn 14 30 quickly quickly RB cord-007277-86lynlxn 14 31 identified identify VBN cord-007277-86lynlxn 14 32 and and CC cord-007277-86lynlxn 14 33 classified classify VBN cord-007277-86lynlxn 14 34 and and CC cord-007277-86lynlxn 14 35 leading lead VBG cord-007277-86lynlxn 14 36 to to IN cord-007277-86lynlxn 14 37 the the DT cord-007277-86lynlxn 14 38 development development NN cord-007277-86lynlxn 14 39 of of IN cord-007277-86lynlxn 14 40 detection detection NN cord-007277-86lynlxn 14 41 methods method NNS cord-007277-86lynlxn 14 42 that that WDT cord-007277-86lynlxn 14 43 would would MD cord-007277-86lynlxn 14 44 guide guide VB cord-007277-86lynlxn 14 45 the the DT cord-007277-86lynlxn 14 46 containment containment NN cord-007277-86lynlxn 14 47 of of IN cord-007277-86lynlxn 14 48 the the DT cord-007277-86lynlxn 14 49 epidemic epidemic NN cord-007277-86lynlxn 14 50 . . . cord-007277-86lynlxn 15 1 It -PRON- PRP cord-007277-86lynlxn 15 2 is be VBZ cord-007277-86lynlxn 15 3 in in IN cord-007277-86lynlxn 15 4 this this DT cord-007277-86lynlxn 15 5 context context NN cord-007277-86lynlxn 15 6 that that IN cord-007277-86lynlxn 15 7 the the DT cord-007277-86lynlxn 15 8 article article NN cord-007277-86lynlxn 15 9 and and CC cord-007277-86lynlxn 15 10 brief brief JJ cord-007277-86lynlxn 15 11 report report NN cord-007277-86lynlxn 15 12 by by IN cord-007277-86lynlxn 15 13 Esper Esper NNP cord-007277-86lynlxn 15 14 et et NNP cord-007277-86lynlxn 15 15 al al NNP cord-007277-86lynlxn 15 16 . . . cord-007277-86lynlxn 16 1 that that WDT cord-007277-86lynlxn 16 2 appear appear VBP cord-007277-86lynlxn 16 3 in in IN cord-007277-86lynlxn 16 4 this this DT cord-007277-86lynlxn 16 5 issue issue NN cord-007277-86lynlxn 16 6 of of IN cord-007277-86lynlxn 16 7 the the DT cord-007277-86lynlxn 16 8 Journal Journal NNP cord-007277-86lynlxn 16 9 of of IN cord-007277-86lynlxn 16 10 Infectious Infectious NNP cord-007277-86lynlxn 16 11 Diseases Diseases NNPS cord-007277-86lynlxn 16 12 should should MD cord-007277-86lynlxn 16 13 be be VB cord-007277-86lynlxn 16 14 read read VBN cord-007277-86lynlxn 16 15 [ [ -LRB- cord-007277-86lynlxn 16 16 11 11 CD cord-007277-86lynlxn 16 17 , , , cord-007277-86lynlxn 16 18 12 12 CD cord-007277-86lynlxn 16 19 ] ] -RRB- cord-007277-86lynlxn 16 20 . . . cord-007277-86lynlxn 17 1 In in IN cord-007277-86lynlxn 17 2 the the DT cord-007277-86lynlxn 17 3 first first JJ cord-007277-86lynlxn 17 4 of of IN cord-007277-86lynlxn 17 5 these these DT cord-007277-86lynlxn 17 6 papers paper NNS cord-007277-86lynlxn 17 7 , , , cord-007277-86lynlxn 17 8 Esper Esper NNP cord-007277-86lynlxn 17 9 et et NNP cord-007277-86lynlxn 17 10 al al NNP cord-007277-86lynlxn 17 11 . . . cord-007277-86lynlxn 18 1 use use VB cord-007277-86lynlxn 18 2 the the DT cord-007277-86lynlxn 18 3 accumulated accumulate VBN cord-007277-86lynlxn 18 4 knowledge knowledge NN cord-007277-86lynlxn 18 5 of of IN cord-007277-86lynlxn 18 6 the the DT cord-007277-86lynlxn 18 7 coronaviral coronaviral JJ cord-007277-86lynlxn 18 8 genomic genomic JJ cord-007277-86lynlxn 18 9 sequence sequence NN cord-007277-86lynlxn 18 10 to to TO cord-007277-86lynlxn 18 11 search search VB cord-007277-86lynlxn 18 12 for for IN cord-007277-86lynlxn 18 13 new new JJ cord-007277-86lynlxn 18 14 HCoVs hcovs CD cord-007277-86lynlxn 18 15 in in IN cord-007277-86lynlxn 18 16 children child NNS cord-007277-86lynlxn 18 17 with with IN cord-007277-86lynlxn 18 18 respiratory respiratory JJ cord-007277-86lynlxn 18 19 disease disease NN cord-007277-86lynlxn 18 20 [ [ -LRB- cord-007277-86lynlxn 18 21 11 11 CD cord-007277-86lynlxn 18 22 ] ] -RRB- cord-007277-86lynlxn 18 23 . . . cord-007277-86lynlxn 19 1 The the DT cord-007277-86lynlxn 19 2 authors author NNS cord-007277-86lynlxn 19 3 ' ' POS cord-007277-86lynlxn 19 4 discovery discovery NN cord-007277-86lynlxn 19 5 of of IN cord-007277-86lynlxn 19 6 a a DT cord-007277-86lynlxn 19 7 previously previously RB cord-007277-86lynlxn 19 8 undescribed undescribed JJ cord-007277-86lynlxn 19 9 HCoV hcov NN cord-007277-86lynlxn 19 10 was be VBD cord-007277-86lynlxn 19 11 accomplished accomplish VBN cord-007277-86lynlxn 19 12 through through IN cord-007277-86lynlxn 19 13 the the DT cord-007277-86lynlxn 19 14 design design NN cord-007277-86lynlxn 19 15 of of IN cord-007277-86lynlxn 19 16 a a DT cord-007277-86lynlxn 19 17 polymerase polymerase NN cord-007277-86lynlxn 19 18 chain chain NN cord-007277-86lynlxn 19 19 reaction reaction NN cord-007277-86lynlxn 19 20 assay assay NN cord-007277-86lynlxn 19 21 that that WDT cord-007277-86lynlxn 19 22 was be VBD cord-007277-86lynlxn 19 23 based base VBN cord-007277-86lynlxn 19 24 on on IN cord-007277-86lynlxn 19 25 the the DT cord-007277-86lynlxn 19 26 common common JJ cord-007277-86lynlxn 19 27 region region NN cord-007277-86lynlxn 19 28 of of IN cord-007277-86lynlxn 19 29 the the DT cord-007277-86lynlxn 19 30 polymerase polymerase NN cord-007277-86lynlxn 19 31 gene gene NN cord-007277-86lynlxn 19 32 . . . cord-007277-86lynlxn 20 1 This this DT cord-007277-86lynlxn 20 2 method method NN cord-007277-86lynlxn 20 3 was be VBD cord-007277-86lynlxn 20 4 logical logical JJ cord-007277-86lynlxn 20 5 , , , cord-007277-86lynlxn 20 6 intelligent intelligent JJ cord-007277-86lynlxn 20 7 , , , cord-007277-86lynlxn 20 8 and and CC cord-007277-86lynlxn 20 9 highly highly RB cord-007277-86lynlxn 20 10 original original JJ cord-007277-86lynlxn 20 11 - - : cord-007277-86lynlxn 20 12 and and CC cord-007277-86lynlxn 20 13 a a DT cord-007277-86lynlxn 20 14 new new JJ cord-007277-86lynlxn 20 15 vi vi NNP cord-007277-86lynlxn 20 16 - - HYPH cord-007277-86lynlxn 20 17 rus rus NNP cord-007277-86lynlxn 20 18 , , , cord-007277-86lynlxn 20 19 designated designate VBN cord-007277-86lynlxn 20 20 " " `` cord-007277-86lynlxn 20 21 New New NNP cord-007277-86lynlxn 20 22 Haven Haven NNP cord-007277-86lynlxn 20 23 coronavirus coronavirus NN cord-007277-86lynlxn 20 24 " " '' cord-007277-86lynlxn 20 25 ( ( -LRB- cord-007277-86lynlxn 20 26 HCoV HCoV NNP cord-007277-86lynlxn 20 27 - - HYPH cord-007277-86lynlxn 20 28 NH NH NNP cord-007277-86lynlxn 20 29 ) ) -RRB- cord-007277-86lynlxn 20 30 , , , cord-007277-86lynlxn 20 31 did do VBD cord-007277-86lynlxn 20 32 appear appear VB cord-007277-86lynlxn 20 33 . . . cord-007277-86lynlxn 21 1 In in IN cord-007277-86lynlxn 21 2 fact fact NN cord-007277-86lynlxn 21 3 , , , cord-007277-86lynlxn 21 4 Esper Esper NNP cord-007277-86lynlxn 21 5 et et NNP cord-007277-86lynlxn 21 6 al al NNP cord-007277-86lynlxn 21 7 . . NNP cord-007277-86lynlxn 21 8 's 's POS cord-007277-86lynlxn 21 9 finding finding NN cord-007277-86lynlxn 21 10 was be VBD cord-007277-86lynlxn 21 11 not not RB cord-007277-86lynlxn 21 12 surprising surprising JJ cord-007277-86lynlxn 21 13 . . . cord-007277-86lynlxn 22 1 The the DT cord-007277-86lynlxn 22 2 reason reason NN cord-007277-86lynlxn 22 3 for for IN cord-007277-86lynlxn 22 4 this this DT cord-007277-86lynlxn 22 5 is be VBZ cord-007277-86lynlxn 22 6 not not RB cord-007277-86lynlxn 22 7 that that IN cord-007277-86lynlxn 22 8 a a DT cord-007277-86lynlxn 22 9 very very RB cord-007277-86lynlxn 22 10 similar similar JJ cord-007277-86lynlxn 22 11 HCoV hcov NN cord-007277-86lynlxn 22 12 was be VBD cord-007277-86lynlxn 22 13 being be VBG cord-007277-86lynlxn 22 14 described describe VBN cord-007277-86lynlxn 22 15 by by IN cord-007277-86lynlxn 22 16 2 2 CD cord-007277-86lynlxn 22 17 independent independent JJ cord-007277-86lynlxn 22 18 groups group NNS cord-007277-86lynlxn 22 19 of of IN cord-007277-86lynlxn 22 20 virologists virologist NNS cord-007277-86lynlxn 22 21 in in IN cord-007277-86lynlxn 22 22 The the DT cord-007277-86lynlxn 22 23 Netherlands Netherlands NNP cord-007277-86lynlxn 22 24 [ [ -LRB- cord-007277-86lynlxn 22 25 13 13 CD cord-007277-86lynlxn 22 26 , , , cord-007277-86lynlxn 22 27 14 14 CD cord-007277-86lynlxn 22 28 ] ] -RRB- cord-007277-86lynlxn 22 29 at at IN cord-007277-86lynlxn 22 30 the the DT cord-007277-86lynlxn 22 31 same same JJ cord-007277-86lynlxn 22 32 time time NN cord-007277-86lynlxn 22 33 ( ( -LRB- cord-007277-86lynlxn 22 34 that that IN cord-007277-86lynlxn 22 35 virus virus NN cord-007277-86lynlxn 22 36 was be VBD cord-007277-86lynlxn 22 37 not not RB cord-007277-86lynlxn 22 38 known know VBN cord-007277-86lynlxn 22 39 when when WRB cord-007277-86lynlxn 22 40 Esper Esper NNP cord-007277-86lynlxn 22 41 et et NNP cord-007277-86lynlxn 22 42 al al NNP cord-007277-86lynlxn 22 43 . . NNP cord-007277-86lynlxn 22 44 started start VBD cord-007277-86lynlxn 22 45 their -PRON- PRP$ cord-007277-86lynlxn 22 46 work work NN cord-007277-86lynlxn 22 47 ) ) -RRB- cord-007277-86lynlxn 22 48 , , , cord-007277-86lynlxn 22 49 but but CC cord-007277-86lynlxn 22 50 rather rather RB cord-007277-86lynlxn 22 51 that that IN cord-007277-86lynlxn 22 52 , , , cord-007277-86lynlxn 22 53 in in IN cord-007277-86lynlxn 22 54 some some DT cord-007277-86lynlxn 22 55 of of IN cord-007277-86lynlxn 22 56 the the DT cord-007277-86lynlxn 22 57 earliest early JJS cord-007277-86lynlxn 22 58 work work NN cord-007277-86lynlxn 22 59 on on IN cord-007277-86lynlxn 22 60 CoVs CoVs NNP cord-007277-86lynlxn 22 61 during during IN cord-007277-86lynlxn 22 62 the the DT cord-007277-86lynlxn 22 63 1960s 1960 NNS cord-007277-86lynlxn 22 64 , , , cord-007277-86lynlxn 22 65 viruses virus NNS cord-007277-86lynlxn 22 66 were be VBD cord-007277-86lynlxn 22 67 reported report VBN cord-007277-86lynlxn 22 68 that that WDT cord-007277-86lynlxn 22 69 were be VBD cord-007277-86lynlxn 22 70 then then RB cord-007277-86lynlxn 22 71 forgotten forget VBN cord-007277-86lynlxn 22 72 - - HYPH cord-007277-86lynlxn 22 73 viruses virus NNS cord-007277-86lynlxn 22 74 that that WDT cord-007277-86lynlxn 22 75 came come VBD cord-007277-86lynlxn 22 76 from from IN cord-007277-86lynlxn 22 77 adults adult NNS cord-007277-86lynlxn 22 78 with with IN cord-007277-86lynlxn 22 79 respiratory respiratory JJ cord-007277-86lynlxn 22 80 illness illness NN cord-007277-86lynlxn 23 1 , , , cord-007277-86lynlxn 23 2 that that WDT cord-007277-86lynlxn 23 3 grew grow VBD cord-007277-86lynlxn 23 4 only only RB cord-007277-86lynlxn 23 5 in in IN cord-007277-86lynlxn 23 6 human human JJ cord-007277-86lynlxn 23 7 embryonic embryonic JJ cord-007277-86lynlxn 23 8 tracheal tracheal JJ cord-007277-86lynlxn 23 9 organ organ NN cord-007277-86lynlxn 23 10 culture culture NN cord-007277-86lynlxn 23 11 , , , cord-007277-86lynlxn 23 12 that that WDT cord-007277-86lynlxn 23 13 caused cause VBD cord-007277-86lynlxn 23 14 illness illness NN cord-007277-86lynlxn 23 15 in in IN cord-007277-86lynlxn 23 16 volunteers volunteer NNS cord-007277-86lynlxn 23 17 , , , cord-007277-86lynlxn 23 18 and and CC cord-007277-86lynlxn 23 19 that that DT cord-007277-86lynlxn 23 20 were be VBD cord-007277-86lynlxn 23 21 not not RB cord-007277-86lynlxn 23 22 , , , cord-007277-86lynlxn 23 23 or or CC cord-007277-86lynlxn 23 24 were be VBD cord-007277-86lynlxn 23 25 only only RB cord-007277-86lynlxn 23 26 distantly distantly RB cord-007277-86lynlxn 23 27 , , , cord-007277-86lynlxn 23 28 antigenically antigenically RB cord-007277-86lynlxn 23 29 related relate VBN cord-007277-86lynlxn 23 30 to to IN cord-007277-86lynlxn 23 31 the the DT cord-007277-86lynlxn 23 32 2 2 CD cord-007277-86lynlxn 23 33 HCoV hcov NN cord-007277-86lynlxn 23 34 species specie NNS cord-007277-86lynlxn 23 35 that that WDT cord-007277-86lynlxn 23 36 were be VBD cord-007277-86lynlxn 23 37 subsequently subsequently RB cord-007277-86lynlxn 23 38 the the DT cord-007277-86lynlxn 23 39 best well RBS cord-007277-86lynlxn 23 40 studied study VBN cord-007277-86lynlxn 23 41 , , , cord-007277-86lynlxn 23 42 HCoV-229E HCoV-229E NNP cord-007277-86lynlxn 23 43 and and CC cord-007277-86lynlxn 23 44 HCoV HCoV NNP cord-007277-86lynlxn 23 45 - - HYPH cord-007277-86lynlxn 23 46 OC43 OC43 NNP cord-007277-86lynlxn 23 47 . . . cord-007277-86lynlxn 24 1 One one CD cord-007277-86lynlxn 24 2 of of IN cord-007277-86lynlxn 24 3 these these DT cord-007277-86lynlxn 24 4 forgotten forget VBN cord-007277-86lynlxn 24 5 viruses virus NNS cord-007277-86lynlxn 24 6 , , , cord-007277-86lynlxn 24 7 B814 B814 NNP cord-007277-86lynlxn 24 8 , , , cord-007277-86lynlxn 24 9 was be VBD cord-007277-86lynlxn 24 10 the the DT cord-007277-86lynlxn 24 11 first first JJ cord-007277-86lynlxn 24 12 HCoV hcov NN cord-007277-86lynlxn 24 13 to to TO cord-007277-86lynlxn 24 14 be be VB cord-007277-86lynlxn 24 15 described describe VBN cord-007277-86lynlxn 24 16 [ [ -LRB- cord-007277-86lynlxn 24 17 1 1 CD cord-007277-86lynlxn 24 18 ] ] -RRB- cord-007277-86lynlxn 24 19 . . . cord-007277-86lynlxn 25 1 The the DT cord-007277-86lynlxn 25 2 others other NNS cord-007277-86lynlxn 25 3 - - HYPH cord-007277-86lynlxn 25 4 HCoV HCoV NNP cord-007277-86lynlxn 25 5 - - HYPH cord-007277-86lynlxn 25 6 OC16 OC16 NNP cord-007277-86lynlxn 25 7 , , , cord-007277-86lynlxn 25 8 HCoV HCoV NNP cord-007277-86lynlxn 25 9 - - HYPH cord-007277-86lynlxn 25 10 OC37 OC37 NNP cord-007277-86lynlxn 25 11 , , , cord-007277-86lynlxn 25 12 and and CC cord-007277-86lynlxn 25 13 HCoV HCoV NNP cord-007277-86lynlxn 25 14 - - : cord-007277-86lynlxn 25 15 OC48-were OC48-were NNP cord-007277-86lynlxn 25 16 3 3 CD cord-007277-86lynlxn 25 17 of of IN cord-007277-86lynlxn 25 18 the the DT cord-007277-86lynlxn 25 19 6 6 CD cord-007277-86lynlxn 25 20 strains strain NNS cord-007277-86lynlxn 25 21 recovered recover VBN cord-007277-86lynlxn 25 22 from from IN cord-007277-86lynlxn 25 23 organ organ NN cord-007277-86lynlxn 25 24 culture culture NN cord-007277-86lynlxn 25 25 in in IN cord-007277-86lynlxn 25 26 my -PRON- PRP$ cord-007277-86lynlxn 25 27 laboratory laboratory NN cord-007277-86lynlxn 25 28 [ [ -LRB- cord-007277-86lynlxn 25 29 15 15 CD cord-007277-86lynlxn 25 30 ] ] -RRB- cord-007277-86lynlxn 25 31 . . . cord-007277-86lynlxn 26 1 All all DT cord-007277-86lynlxn 26 2 4 4 CD cord-007277-86lynlxn 26 3 of of IN cord-007277-86lynlxn 26 4 these these DT cord-007277-86lynlxn 26 5 strains strain NNS cord-007277-86lynlxn 26 6 produced produce VBD cord-007277-86lynlxn 26 7 colds cold NNS cord-007277-86lynlxn 26 8 in in IN cord-007277-86lynlxn 26 9 volunteers volunteer NNS cord-007277-86lynlxn 26 10 [ [ -LRB- cord-007277-86lynlxn 26 11 2 2 CD cord-007277-86lynlxn 26 12 , , , cord-007277-86lynlxn 26 13 3 3 CD cord-007277-86lynlxn 26 14 ] ] -RRB- cord-007277-86lynlxn 26 15 , , , cord-007277-86lynlxn 26 16 but but CC cord-007277-86lynlxn 26 17 none none NN cord-007277-86lynlxn 26 18 grew grow VBD cord-007277-86lynlxn 26 19 in in IN cord-007277-86lynlxn 26 20 tissue tissue NN cord-007277-86lynlxn 26 21 culture culture NN cord-007277-86lynlxn 26 22 , , , cord-007277-86lynlxn 26 23 and and CC cord-007277-86lynlxn 26 24 none none NN cord-007277-86lynlxn 26 25 could could MD cord-007277-86lynlxn 26 26 be be VB cord-007277-86lynlxn 26 27 adapted adapt VBN cord-007277-86lynlxn 26 28 to to TO cord-007277-86lynlxn 26 29 grow grow VB cord-007277-86lynlxn 26 30 in in IN cord-007277-86lynlxn 26 31 animal animal NN cord-007277-86lynlxn 26 32 models model NNS cord-007277-86lynlxn 26 33 . . . cord-007277-86lynlxn 27 1 Thus thus RB cord-007277-86lynlxn 27 2 , , , cord-007277-86lynlxn 27 3 the the DT cord-007277-86lynlxn 27 4 subsequent subsequent JJ cord-007277-86lynlxn 27 5 neglect neglect NN cord-007277-86lynlxn 27 6 of of IN cord-007277-86lynlxn 27 7 these these DT cord-007277-86lynlxn 27 8 potentially potentially RB cord-007277-86lynlxn 27 9 important important JJ cord-007277-86lynlxn 27 10 viruses virus NNS cord-007277-86lynlxn 27 11 stemmed stem VBD cord-007277-86lynlxn 27 12 from from IN cord-007277-86lynlxn 27 13 the the DT cord-007277-86lynlxn 27 14 fact fact NN cord-007277-86lynlxn 27 15 that that IN cord-007277-86lynlxn 27 16 , , , cord-007277-86lynlxn 27 17 essentially essentially RB cord-007277-86lynlxn 27 18 , , , cord-007277-86lynlxn 27 19 no no DT cord-007277-86lynlxn 27 20 methods method NNS cord-007277-86lynlxn 27 21 were be VBD cord-007277-86lynlxn 27 22 available available JJ cord-007277-86lynlxn 27 23 to to TO cord-007277-86lynlxn 27 24 study study VB cord-007277-86lynlxn 27 25 them -PRON- PRP cord-007277-86lynlxn 27 26 at at IN cord-007277-86lynlxn 27 27 the the DT cord-007277-86lynlxn 27 28 time time NN cord-007277-86lynlxn 27 29 . . . cord-007277-86lynlxn 28 1 Esper Esper NNP cord-007277-86lynlxn 28 2 et et NNP cord-007277-86lynlxn 28 3 al al NNP cord-007277-86lynlxn 28 4 . . NNP cord-007277-86lynlxn 28 5 's 's POS cord-007277-86lynlxn 28 6 findings finding NNS cord-007277-86lynlxn 28 7 on on IN cord-007277-86lynlxn 28 8 the the DT cord-007277-86lynlxn 28 9 clinical clinical JJ cord-007277-86lynlxn 28 10 impact impact NN cord-007277-86lynlxn 28 11 of of IN cord-007277-86lynlxn 28 12 HCoV HCoV NNP cord-007277-86lynlxn 28 13 - - HYPH cord-007277-86lynlxn 28 14 NH NH NNP cord-007277-86lynlxn 28 15 infection infection NN cord-007277-86lynlxn 28 16 , , , cord-007277-86lynlxn 28 17 although although IN cord-007277-86lynlxn 28 18 limited limit VBN cord-007277-86lynlxn 28 19 , , , cord-007277-86lynlxn 28 20 are be VBP cord-007277-86lynlxn 28 21 consistent consistent JJ cord-007277-86lynlxn 28 22 both both CC cord-007277-86lynlxn 28 23 with with IN cord-007277-86lynlxn 28 24 those those DT cord-007277-86lynlxn 28 25 from from IN cord-007277-86lynlxn 28 26 Europe Europe NNP cord-007277-86lynlxn 28 27 on on IN cord-007277-86lynlxn 28 28 the the DT cord-007277-86lynlxn 28 29 novel novel NN cord-007277-86lynlxn 28 30 HCoV hcov NN cord-007277-86lynlxn 28 31 reported report VBN cord-007277-86lynlxn 28 32 in in IN cord-007277-86lynlxn 28 33 The the DT cord-007277-86lynlxn 28 34 Netherlands Netherlands NNP cord-007277-86lynlxn 28 35 and and CC cord-007277-86lynlxn 28 36 with with IN cord-007277-86lynlxn 28 37 the the DT cord-007277-86lynlxn 28 38 available available JJ cord-007277-86lynlxn 28 39 information information NN cord-007277-86lynlxn 28 40 on on IN cord-007277-86lynlxn 28 41 HCoV-229E HCoV-229E NNP cord-007277-86lynlxn 28 42 and and CC cord-007277-86lynlxn 28 43 HCoV HCoV NNP cord-007277-86lynlxn 28 44 - - HYPH cord-007277-86lynlxn 28 45 OC43 OC43 NNP cord-007277-86lynlxn 28 46 infection infection NN cord-007277-86lynlxn 28 47 in in IN cord-007277-86lynlxn 28 48 children child NNS cord-007277-86lynlxn 28 49 hospitalized hospitalize VBN cord-007277-86lynlxn 28 50 with with IN cord-007277-86lynlxn 28 51 acute acute JJ cord-007277-86lynlxn 28 52 respiratory respiratory JJ cord-007277-86lynlxn 28 53 disease disease NN cord-007277-86lynlxn 28 54 [ [ -LRB- cord-007277-86lynlxn 28 55 5 5 CD cord-007277-86lynlxn 28 56 , , , cord-007277-86lynlxn 28 57 13 13 CD cord-007277-86lynlxn 28 58 , , , cord-007277-86lynlxn 28 59 14 14 CD cord-007277-86lynlxn 28 60 ] ] -RRB- cord-007277-86lynlxn 28 61 . . . cord-007277-86lynlxn 29 1 However however RB cord-007277-86lynlxn 29 2 , , , cord-007277-86lynlxn 29 3 the the DT cord-007277-86lynlxn 29 4 details detail NNS cord-007277-86lynlxn 29 5 from from IN cord-007277-86lynlxn 29 6 Esper Esper NNP cord-007277-86lynlxn 29 7 et et NNP cord-007277-86lynlxn 29 8 al al NNP cord-007277-86lynlxn 29 9 . . NNP cord-007277-86lynlxn 29 10 's 's POS cord-007277-86lynlxn 29 11 study study NN cord-007277-86lynlxn 29 12 - - : cord-007277-86lynlxn 29 13 the the DT cord-007277-86lynlxn 29 14 seasonal seasonal JJ cord-007277-86lynlxn 29 15 distribution distribution NN cord-007277-86lynlxn 29 16 , , , cord-007277-86lynlxn 29 17 the the DT cord-007277-86lynlxn 29 18 percentage percentage NN cord-007277-86lynlxn 29 19 of of IN cord-007277-86lynlxn 29 20 positive positive JJ cord-007277-86lynlxn 29 21 samples sample NNS cord-007277-86lynlxn 29 22 , , , cord-007277-86lynlxn 29 23 the the DT cord-007277-86lynlxn 29 24 associated associated JJ cord-007277-86lynlxn 29 25 respiratory respiratory JJ cord-007277-86lynlxn 29 26 syndromes syndrome NNS cord-007277-86lynlxn 29 27 , , , cord-007277-86lynlxn 29 28 and and CC cord-007277-86lynlxn 29 29 the the DT cord-007277-86lynlxn 29 30 numbers number NNS cord-007277-86lynlxn 29 31 of of IN cord-007277-86lynlxn 29 32 infected infected JJ cord-007277-86lynlxn 29 33 children child NNS cord-007277-86lynlxn 29 34 at at IN cord-007277-86lynlxn 29 35 various various JJ cord-007277-86lynlxn 29 36 ages age NNS cord-007277-86lynlxn 29 37 , , , cord-007277-86lynlxn 29 38 for for IN cord-007277-86lynlxn 29 39 example example NN cord-007277-86lynlxn 29 40 - - , cord-007277-86lynlxn 29 41 were be VBD cord-007277-86lynlxn 29 42 heavily heavily RB cord-007277-86lynlxn 29 43 influenced influence VBN cord-007277-86lynlxn 29 44 by by IN cord-007277-86lynlxn 29 45 both both CC cord-007277-86lynlxn 29 46 the the DT cord-007277-86lynlxn 29 47 particular particular JJ cord-007277-86lynlxn 29 48 population population NN cord-007277-86lynlxn 29 49 that that WDT cord-007277-86lynlxn 29 50 was be VBD cord-007277-86lynlxn 29 51 investigated investigate VBN cord-007277-86lynlxn 29 52 and and CC cord-007277-86lynlxn 29 53 the the DT cord-007277-86lynlxn 29 54 clinical clinical JJ cord-007277-86lynlxn 29 55 setting setting NN cord-007277-86lynlxn 29 56 , , , cord-007277-86lynlxn 29 57 so so CC cord-007277-86lynlxn 29 58 it -PRON- PRP cord-007277-86lynlxn 29 59 is be VBZ cord-007277-86lynlxn 29 60 essentially essentially RB cord-007277-86lynlxn 29 61 impossible impossible JJ cord-007277-86lynlxn 29 62 to to TO cord-007277-86lynlxn 29 63 draw draw VB cord-007277-86lynlxn 29 64 conclusions conclusion NNS cord-007277-86lynlxn 29 65 on on IN cord-007277-86lynlxn 29 66 the the DT cord-007277-86lynlxn 29 67 epidemiology epidemiology NN cord-007277-86lynlxn 29 68 , , , cord-007277-86lynlxn 29 69 pathogenicity pathogenicity NN cord-007277-86lynlxn 29 70 , , , cord-007277-86lynlxn 29 71 and and CC cord-007277-86lynlxn 29 72 relative relative JJ cord-007277-86lynlxn 29 73 importance importance NN cord-007277-86lynlxn 29 74 of of IN cord-007277-86lynlxn 29 75 HCoV HCoV NNP cord-007277-86lynlxn 29 76 - - HYPH cord-007277-86lynlxn 29 77 NH NH NNP cord-007277-86lynlxn 29 78 in in IN cord-007277-86lynlxn 29 79 relation relation NN cord-007277-86lynlxn 29 80 to to IN cord-007277-86lynlxn 29 81 other other JJ cord-007277-86lynlxn 29 82 respiratory respiratory JJ cord-007277-86lynlxn 29 83 viruses virus NNS cord-007277-86lynlxn 29 84 . . . cord-007277-86lynlxn 30 1 On on IN cord-007277-86lynlxn 30 2 the the DT cord-007277-86lynlxn 30 3 other other JJ cord-007277-86lynlxn 30 4 hand hand NN cord-007277-86lynlxn 30 5 , , , cord-007277-86lynlxn 30 6 it -PRON- PRP cord-007277-86lynlxn 30 7 seems seem VBZ cord-007277-86lynlxn 30 8 to to TO cord-007277-86lynlxn 30 9 be be VB cord-007277-86lynlxn 30 10 likely likely JJ cord-007277-86lynlxn 30 11 that that IN cord-007277-86lynlxn 30 12 this this DT cord-007277-86lynlxn 30 13 is be VBZ cord-007277-86lynlxn 30 14 not not RB cord-007277-86lynlxn 30 15 the the DT cord-007277-86lynlxn 30 16 last last JJ cord-007277-86lynlxn 30 17 chapter chapter NN cord-007277-86lynlxn 30 18 in in IN cord-007277-86lynlxn 30 19 the the DT cord-007277-86lynlxn 30 20 story story NN cord-007277-86lynlxn 30 21 of of IN cord-007277-86lynlxn 30 22 respiratory respiratory JJ cord-007277-86lynlxn 30 23 HCoVs hcovs NN cord-007277-86lynlxn 30 24 and and CC cord-007277-86lynlxn 30 25 that that IN cord-007277-86lynlxn 30 26 additional additional JJ cord-007277-86lynlxn 30 27 studies study NNS cord-007277-86lynlxn 30 28 will will MD cord-007277-86lynlxn 30 29 clarify clarify VB cord-007277-86lynlxn 30 30 the the DT cord-007277-86lynlxn 30 31 picture picture NN cord-007277-86lynlxn 30 32 . . . cord-007277-86lynlxn 31 1 Moreover moreover RB cord-007277-86lynlxn 31 2 , , , cord-007277-86lynlxn 31 3 it -PRON- PRP cord-007277-86lynlxn 31 4 seems seem VBZ cord-007277-86lynlxn 31 5 quite quite RB cord-007277-86lynlxn 31 6 possible possible JJ cord-007277-86lynlxn 31 7 that that IN cord-007277-86lynlxn 31 8 other other JJ cord-007277-86lynlxn 31 9 strains strain NNS cord-007277-86lynlxn 31 10 will will MD cord-007277-86lynlxn 31 11 be be VB cord-007277-86lynlxn 31 12 found find VBN cord-007277-86lynlxn 31 13 , , , cord-007277-86lynlxn 31 14 by by IN cord-007277-86lynlxn 31 15 use use NN cord-007277-86lynlxn 31 16 of of IN cord-007277-86lynlxn 31 17 similar similar JJ cord-007277-86lynlxn 31 18 methods method NNS cord-007277-86lynlxn 31 19 . . . cord-007277-86lynlxn 32 1 In in IN cord-007277-86lynlxn 32 2 contrast contrast NN cord-007277-86lynlxn 32 3 , , , cord-007277-86lynlxn 32 4 the the DT cord-007277-86lynlxn 32 5 findings finding NNS cord-007277-86lynlxn 32 6 reported report VBN cord-007277-86lynlxn 32 7 in in IN cord-007277-86lynlxn 32 8 Esper Esper NNP cord-007277-86lynlxn 32 9 et et NNP cord-007277-86lynlxn 32 10 al al NNP cord-007277-86lynlxn 32 11 . . NNP cord-007277-86lynlxn 32 12 's 's POS cord-007277-86lynlxn 32 13 brief brief JJ cord-007277-86lynlxn 32 14 report report NN cord-007277-86lynlxn 32 15 were be VBD cord-007277-86lynlxn 32 16 , , , cord-007277-86lynlxn 32 17 to to IN cord-007277-86lynlxn 32 18 this this DT cord-007277-86lynlxn 32 19 reader reader NN cord-007277-86lynlxn 32 20 , , , cord-007277-86lynlxn 32 21 quite quite RB cord-007277-86lynlxn 32 22 surprising surprising JJ cord-007277-86lynlxn 32 23 [ [ -LRB- cord-007277-86lynlxn 32 24 12 12 CD cord-007277-86lynlxn 32 25 ] ] -RRB- cord-007277-86lynlxn 32 26 . . . cord-007277-86lynlxn 33 1 Esper Esper NNP cord-007277-86lynlxn 33 2 et et NNP cord-007277-86lynlxn 33 3 al al NNP cord-007277-86lynlxn 33 4 . . NNP cord-007277-86lynlxn 33 5 have have VBP cord-007277-86lynlxn 33 6 shown show VBN cord-007277-86lynlxn 33 7 a a DT cord-007277-86lynlxn 33 8 temporal temporal JJ cord-007277-86lynlxn 33 9 association association NN cord-007277-86lynlxn 33 10 with with IN cord-007277-86lynlxn 33 11 quite quite RB cord-007277-86lynlxn 33 12 strong strong JJ cord-007277-86lynlxn 33 13 statistical statistical JJ cord-007277-86lynlxn 33 14 significance significance NN cord-007277-86lynlxn 33 15 between between IN cord-007277-86lynlxn 33 16 infection infection NN cord-007277-86lynlxn 33 17 with with IN cord-007277-86lynlxn 33 18 HCoV HCoV NNP cord-007277-86lynlxn 33 19 - - HYPH cord-007277-86lynlxn 33 20 NH NH NNP cord-007277-86lynlxn 33 21 and and CC cord-007277-86lynlxn 33 22 Kawasaki Kawasaki NNP cord-007277-86lynlxn 33 23 disease disease NN cord-007277-86lynlxn 33 24 , , , cord-007277-86lynlxn 33 25 establishing establish VBG cord-007277-86lynlxn 33 26 this this DT cord-007277-86lynlxn 33 27 association association NN cord-007277-86lynlxn 33 28 by by IN cord-007277-86lynlxn 33 29 means mean NNS cord-007277-86lynlxn 33 30 of of IN cord-007277-86lynlxn 33 31 a a DT cord-007277-86lynlxn 33 32 case case NN cord-007277-86lynlxn 33 33 - - HYPH cord-007277-86lynlxn 33 34 control control NN cord-007277-86lynlxn 33 35 study study NN cord-007277-86lynlxn 33 36 in in IN cord-007277-86lynlxn 33 37 hospitalized hospitalize VBN cord-007277-86lynlxn 33 38 children child NNS cord-007277-86lynlxn 33 39 . . . cord-007277-86lynlxn 34 1 Until until IN cord-007277-86lynlxn 34 2 there there EX cord-007277-86lynlxn 34 3 are be VBP cord-007277-86lynlxn 34 4 corroborating corroborate VBG cord-007277-86lynlxn 34 5 studies study NNS cord-007277-86lynlxn 34 6 , , , cord-007277-86lynlxn 34 7 it -PRON- PRP cord-007277-86lynlxn 34 8 would would MD cord-007277-86lynlxn 34 9 seem seem VB cord-007277-86lynlxn 34 10 wise wise JJ cord-007277-86lynlxn 34 11 to to TO cord-007277-86lynlxn 34 12 retain retain VB cord-007277-86lynlxn 34 13 a a DT cord-007277-86lynlxn 34 14 healthy healthy JJ cord-007277-86lynlxn 34 15 level level NN cord-007277-86lynlxn 34 16 of of IN cord-007277-86lynlxn 34 17 skepticism skepticism NN cord-007277-86lynlxn 34 18 with with IN cord-007277-86lynlxn 34 19 regard regard NN cord-007277-86lynlxn 34 20 to to IN cord-007277-86lynlxn 34 21 the the DT cord-007277-86lynlxn 34 22 significance significance NN cord-007277-86lynlxn 34 23 of of IN cord-007277-86lynlxn 34 24 this this DT cord-007277-86lynlxn 34 25 association association NN cord-007277-86lynlxn 34 26 . . . cord-007277-86lynlxn 35 1 Nevertheless nevertheless RB cord-007277-86lynlxn 35 2 , , , cord-007277-86lynlxn 35 3 the the DT cord-007277-86lynlxn 35 4 findings finding NNS cord-007277-86lynlxn 35 5 are be VBP cord-007277-86lynlxn 35 6 extremely extremely RB cord-007277-86lynlxn 35 7 interesting interesting JJ cord-007277-86lynlxn 35 8 and and CC cord-007277-86lynlxn 35 9 set set VBN cord-007277-86lynlxn 35 10 off off RP cord-007277-86lynlxn 35 11 in in IN cord-007277-86lynlxn 35 12 me -PRON- PRP cord-007277-86lynlxn 35 13 a a DT cord-007277-86lynlxn 35 14 series series NN cord-007277-86lynlxn 35 15 of of IN cord-007277-86lynlxn 35 16 thoughts thought NNS cord-007277-86lynlxn 35 17 as as IN cord-007277-86lynlxn 35 18 to to IN cord-007277-86lynlxn 35 19 what what WP cord-007277-86lynlxn 35 20 might may MD cord-007277-86lynlxn 35 21 be be VB cord-007277-86lynlxn 35 22 going go VBG cord-007277-86lynlxn 35 23 on on RP cord-007277-86lynlxn 35 24 . . . cord-007277-86lynlxn 36 1 First first RB cord-007277-86lynlxn 36 2 , , , cord-007277-86lynlxn 36 3 the the DT cord-007277-86lynlxn 36 4 skepticism skepticism NN cord-007277-86lynlxn 36 5 . . . cord-007277-86lynlxn 37 1 The the DT cord-007277-86lynlxn 37 2 linking linking NN cord-007277-86lynlxn 37 3 of of IN cord-007277-86lynlxn 37 4 an an DT cord-007277-86lynlxn 37 5 agent agent NN cord-007277-86lynlxn 37 6 to to IN cord-007277-86lynlxn 37 7 Kawasaki Kawasaki NNP cord-007277-86lynlxn 37 8 disease disease NN cord-007277-86lynlxn 37 9 follows follow VBZ cord-007277-86lynlxn 37 10 a a DT cord-007277-86lynlxn 37 11 long long JJ cord-007277-86lynlxn 37 12 trail trail NN cord-007277-86lynlxn 37 13 of of IN cord-007277-86lynlxn 37 14 previously previously RB cord-007277-86lynlxn 37 15 failed fail VBN cord-007277-86lynlxn 37 16 or or CC cord-007277-86lynlxn 37 17 still still RB cord-007277-86lynlxn 37 18 - - HYPH cord-007277-86lynlxn 37 19 struggling struggle VBG cord-007277-86lynlxn 37 20 attempts attempt NNS cord-007277-86lynlxn 37 21 to to TO cord-007277-86lynlxn 37 22 identify identify VB cord-007277-86lynlxn 37 23 the the DT cord-007277-86lynlxn 37 24 etiologic etiologic JJ cord-007277-86lynlxn 37 25 agent agent NN cord-007277-86lynlxn 37 26 of of IN cord-007277-86lynlxn 37 27 this this DT cord-007277-86lynlxn 37 28 important important JJ cord-007277-86lynlxn 37 29 syndrome syndrome NN cord-007277-86lynlxn 37 30 , , , cord-007277-86lynlxn 37 31 ranging range VBG cord-007277-86lynlxn 37 32 from from IN cord-007277-86lynlxn 37 33 an an DT cord-007277-86lynlxn 37 34 unidentified unidentified JJ cord-007277-86lynlxn 37 35 retrovirus retrovirus NN cord-007277-86lynlxn 37 36 [ [ -LRB- cord-007277-86lynlxn 37 37 16 16 CD cord-007277-86lynlxn 37 38 ] ] -RRB- cord-007277-86lynlxn 37 39 , , , cord-007277-86lynlxn 37 40 to to TO cord-007277-86lynlxn 37 41 parvovirus parvovirus VB cord-007277-86lynlxn 37 42 B19 B19 NNP cord-007277-86lynlxn 37 43 [ [ -LRB- cord-007277-86lynlxn 37 44 17 17 CD cord-007277-86lynlxn 37 45 ] ] -RRB- cord-007277-86lynlxn 37 46 , , , cord-007277-86lynlxn 37 47 to to IN cord-007277-86lynlxn 37 48 Epstein Epstein NNP cord-007277-86lynlxn 37 49 - - HYPH cord-007277-86lynlxn 37 50 Barr Barr NNP cord-007277-86lynlxn 37 51 virus virus NN cord-007277-86lynlxn 37 52 [ [ -LRB- cord-007277-86lynlxn 37 53 18 18 CD cord-007277-86lynlxn 37 54 ] ] -RRB- cord-007277-86lynlxn 37 55 , , , cord-007277-86lynlxn 37 56 to to IN cord-007277-86lynlxn 37 57 Chlamydia Chlamydia NNP cord-007277-86lynlxn 37 58 pneumoniae pneumoniae NN cord-007277-86lynlxn 37 59 [ [ -LRB- cord-007277-86lynlxn 37 60 19 19 CD cord-007277-86lynlxn 37 61 ] ] -RRB- cord-007277-86lynlxn 37 62 , , , cord-007277-86lynlxn 37 63 and and CC cord-007277-86lynlxn 37 64 to to IN cord-007277-86lynlxn 37 65 toxinproducing toxinproduce VBG cord-007277-86lynlxn 37 66 Staphylococcus Staphylococcus NNP cord-007277-86lynlxn 37 67 aureus aureus NN cord-007277-86lynlxn 37 68 or or CC cord-007277-86lynlxn 37 69 Streptococcus streptococcus NN cord-007277-86lynlxn 37 70 pyogenes pyogene NNS cord-007277-86lynlxn 37 71 [ [ -LRB- cord-007277-86lynlxn 37 72 20 20 CD cord-007277-86lynlxn 37 73 ] ] -RRB- cord-007277-86lynlxn 37 74 , , , cord-007277-86lynlxn 37 75 with with IN cord-007277-86lynlxn 37 76 a a DT cord-007277-86lynlxn 37 77 scattering scattering NN cord-007277-86lynlxn 37 78 of of IN cord-007277-86lynlxn 37 79 others other NNS cord-007277-86lynlxn 37 80 along along IN cord-007277-86lynlxn 37 81 the the DT cord-007277-86lynlxn 37 82 way way NN cord-007277-86lynlxn 37 83 . . . cord-007277-86lynlxn 38 1 Although although IN cord-007277-86lynlxn 38 2 the the DT cord-007277-86lynlxn 38 3 association association NN cord-007277-86lynlxn 38 4 shown show VBN cord-007277-86lynlxn 38 5 by by IN cord-007277-86lynlxn 38 6 Esper Esper NNP cord-007277-86lynlxn 38 7 et et NNP cord-007277-86lynlxn 38 8 al al NNP cord-007277-86lynlxn 38 9 . . NNP cord-007277-86lynlxn 38 10 was be VBD cord-007277-86lynlxn 38 11 statistically statistically RB cord-007277-86lynlxn 38 12 compelling compelling JJ cord-007277-86lynlxn 38 13 , , , cord-007277-86lynlxn 38 14 previous previous JJ cord-007277-86lynlxn 38 15 initial initial JJ cord-007277-86lynlxn 38 16 find find NN cord-007277-86lynlxn 38 17 - - HYPH cord-007277-86lynlxn 38 18 ings ing NNS cord-007277-86lynlxn 38 19 were be VBD cord-007277-86lynlxn 38 20 equally equally RB cord-007277-86lynlxn 38 21 so so RB cord-007277-86lynlxn 38 22 ( ( -LRB- cord-007277-86lynlxn 38 23 the the DT cord-007277-86lynlxn 38 24 first first JJ cord-007277-86lynlxn 38 25 descriptions description NNS cord-007277-86lynlxn 38 26 of of IN cord-007277-86lynlxn 38 27 both both DT cord-007277-86lynlxn 38 28 parvovirus parvovirus NN cord-007277-86lynlxn 38 29 B19 B19 NNP cord-007277-86lynlxn 38 30 and and CC cord-007277-86lynlxn 38 31 the the DT cord-007277-86lynlxn 38 32 toxin toxin NN cord-007277-86lynlxn 38 33 - - HYPH cord-007277-86lynlxn 38 34 producing produce VBG cord-007277-86lynlxn 38 35 bacteria bacteria NNS cord-007277-86lynlxn 38 36 included include VBD cord-007277-86lynlxn 38 37 similarly similarly RB cord-007277-86lynlxn 38 38 significant significant JJ cord-007277-86lynlxn 38 39 associations association NNS cord-007277-86lynlxn 38 40 ) ) -RRB- cord-007277-86lynlxn 38 41 and and CC cord-007277-86lynlxn 38 42 have have VBP cord-007277-86lynlxn 38 43 been be VBN cord-007277-86lynlxn 38 44 difficult difficult JJ cord-007277-86lynlxn 38 45 to to TO cord-007277-86lynlxn 38 46 confirm confirm VB cord-007277-86lynlxn 38 47 . . . cord-007277-86lynlxn 39 1 There there EX cord-007277-86lynlxn 39 2 are be VBP cord-007277-86lynlxn 39 3 , , , cord-007277-86lynlxn 39 4 however however RB cord-007277-86lynlxn 39 5 , , , cord-007277-86lynlxn 39 6 some some DT cord-007277-86lynlxn 39 7 tantalizing tantalizing JJ cord-007277-86lynlxn 39 8 facts fact NNS cord-007277-86lynlxn 39 9 about about IN cord-007277-86lynlxn 39 10 both both CC cord-007277-86lynlxn 39 11 CoVs CoVs NNP cord-007277-86lynlxn 39 12 and and CC cord-007277-86lynlxn 39 13 Kawasaki Kawasaki NNP cord-007277-86lynlxn 39 14 disease disease NN cord-007277-86lynlxn 39 15 that that WDT cord-007277-86lynlxn 39 16 might may MD cord-007277-86lynlxn 39 17 allow allow VB cord-007277-86lynlxn 39 18 for for IN cord-007277-86lynlxn 39 19 cautious cautious JJ cord-007277-86lynlxn 39 20 optimism optimism NN cord-007277-86lynlxn 39 21 with with IN cord-007277-86lynlxn 39 22 regard regard NN cord-007277-86lynlxn 39 23 to to IN cord-007277-86lynlxn 39 24 Esper Esper NNP cord-007277-86lynlxn 39 25 et et NNP cord-007277-86lynlxn 39 26 al al NNP cord-007277-86lynlxn 39 27 . . NNP cord-007277-86lynlxn 39 28 's 's POS cord-007277-86lynlxn 39 29 reported report VBD cord-007277-86lynlxn 39 30 association association NN cord-007277-86lynlxn 39 31 . . . cord-007277-86lynlxn 40 1 First first RB cord-007277-86lynlxn 40 2 , , , cord-007277-86lynlxn 40 3 there there EX cord-007277-86lynlxn 40 4 was be VBD cord-007277-86lynlxn 40 5 early early RB cord-007277-86lynlxn 40 6 epidemiologic epidemiologic JJ cord-007277-86lynlxn 40 7 evidence evidence NN cord-007277-86lynlxn 40 8 [ [ -LRB- cord-007277-86lynlxn 40 9 21 21 CD cord-007277-86lynlxn 40 10 ] ] -RRB- cord-007277-86lynlxn 40 11 , , , cord-007277-86lynlxn 40 12 subsequently subsequently RB cord-007277-86lynlxn 40 13 confirmed confirm VBD cord-007277-86lynlxn 40 14 [ [ -LRB- cord-007277-86lynlxn 40 15 22 22 CD cord-007277-86lynlxn 40 16 ] ] -RRB- cord-007277-86lynlxn 40 17 , , , cord-007277-86lynlxn 40 18 that that IN cord-007277-86lynlxn 40 19 a a DT cord-007277-86lynlxn 40 20 respiratory respiratory JJ cord-007277-86lynlxn 40 21 syndrome syndrome NN cord-007277-86lynlxn 40 22 preceded precede VBD cord-007277-86lynlxn 40 23 the the DT cord-007277-86lynlxn 40 24 onset onset NN cord-007277-86lynlxn 40 25 of of IN cord-007277-86lynlxn 40 26 Kawasaki Kawasaki NNP cord-007277-86lynlxn 40 27 disease disease NN cord-007277-86lynlxn 40 28 . . . cord-007277-86lynlxn 41 1 ( ( -LRB- cord-007277-86lynlxn 41 2 Incidentally incidentally RB cord-007277-86lynlxn 41 3 , , , cord-007277-86lynlxn 41 4 the the DT cord-007277-86lynlxn 41 5 interval interval NN cord-007277-86lynlxn 41 6 between between IN cord-007277-86lynlxn 41 7 the the DT cord-007277-86lynlxn 41 8 onset onset NN cord-007277-86lynlxn 41 9 of of IN cord-007277-86lynlxn 41 10 the the DT cord-007277-86lynlxn 41 11 respiratory respiratory JJ cord-007277-86lynlxn 41 12 syndrome syndrome NN cord-007277-86lynlxn 41 13 and and CC cord-007277-86lynlxn 41 14 the the DT cord-007277-86lynlxn 41 15 onset onset NN cord-007277-86lynlxn 41 16 of of IN cord-007277-86lynlxn 41 17 Kawasaki Kawasaki NNP cord-007277-86lynlxn 41 18 disease disease NN cord-007277-86lynlxn 41 19 appeared appear VBD cord-007277-86lynlxn 41 20 to to TO cord-007277-86lynlxn 41 21 be be VB cord-007277-86lynlxn 41 22 ∼2 ∼2 JJ cord-007277-86lynlxn 41 23 weeks week NNS cord-007277-86lynlxn 41 24 [ [ -LRB- cord-007277-86lynlxn 41 25 21 21 CD cord-007277-86lynlxn 41 26 ] ] -RRB- cord-007277-86lynlxn 41 27 , , , cord-007277-86lynlxn 41 28 which which WDT cord-007277-86lynlxn 41 29 seems seem VBZ cord-007277-86lynlxn 41 30 a a DT cord-007277-86lynlxn 41 31 long long JJ cord-007277-86lynlxn 41 32 time time NN cord-007277-86lynlxn 41 33 for for IN cord-007277-86lynlxn 41 34 the the DT cord-007277-86lynlxn 41 35 shedding shedding NN cord-007277-86lynlxn 41 36 of of IN cord-007277-86lynlxn 41 37 a a DT cord-007277-86lynlxn 41 38 respiratory respiratory JJ cord-007277-86lynlxn 41 39 HCoV hcov NN cord-007277-86lynlxn 41 40 , , , cord-007277-86lynlxn 41 41 although although IN cord-007277-86lynlxn 41 42 pertinent pertinent JJ cord-007277-86lynlxn 41 43 data datum NNS cord-007277-86lynlxn 41 44 on on IN cord-007277-86lynlxn 41 45 infants infant NNS cord-007277-86lynlxn 41 46 are be VBP cord-007277-86lynlxn 41 47 lacking lack VBG cord-007277-86lynlxn 41 48 [ [ -LRB- cord-007277-86lynlxn 41 49 23 23 CD cord-007277-86lynlxn 41 50 ] ] -RRB- cord-007277-86lynlxn 42 1 [ [ -LRB- cord-007277-86lynlxn 42 2 24 24 CD cord-007277-86lynlxn 42 3 ] ] -RRB- cord-007277-86lynlxn 42 4 [ [ -LRB- cord-007277-86lynlxn 42 5 25 25 CD cord-007277-86lynlxn 42 6 ] ] -RRB- cord-007277-86lynlxn 42 7 . . . cord-007277-86lynlxn 42 8 ) ) -RRB- cord-007277-86lynlxn 43 1 Second second RB cord-007277-86lynlxn 43 2 , , , cord-007277-86lynlxn 43 3 Kawasaki Kawasaki NNP cord-007277-86lynlxn 43 4 disease disease NN cord-007277-86lynlxn 43 5 is be VBZ cord-007277-86lynlxn 43 6 frequently frequently RB cord-007277-86lynlxn 43 7 seasonal seasonal JJ cord-007277-86lynlxn 43 8 , , , cord-007277-86lynlxn 43 9 with with IN cord-007277-86lynlxn 43 10 peaks peak NNS cord-007277-86lynlxn 43 11 during during IN cord-007277-86lynlxn 43 12 the the DT cord-007277-86lynlxn 43 13 winter winter NN cord-007277-86lynlxn 43 14 and and CC cord-007277-86lynlxn 43 15 spring spring NN cord-007277-86lynlxn 43 16 ; ; : cord-007277-86lynlxn 43 17 its -PRON- PRP$ cord-007277-86lynlxn 43 18 seasonality seasonality NN cord-007277-86lynlxn 43 19 is be VBZ cord-007277-86lynlxn 43 20 roughly roughly RB cord-007277-86lynlxn 43 21 similar similar JJ cord-007277-86lynlxn 43 22 to to IN cord-007277-86lynlxn 43 23 that that DT cord-007277-86lynlxn 43 24 of of IN cord-007277-86lynlxn 43 25 infection infection NN cord-007277-86lynlxn 43 26 with with IN cord-007277-86lynlxn 43 27 respiratory respiratory JJ cord-007277-86lynlxn 43 28 HCoVs hcovs CD cord-007277-86lynlxn 43 29 [ [ -LRB- cord-007277-86lynlxn 43 30 5 5 CD cord-007277-86lynlxn 43 31 , , , cord-007277-86lynlxn 43 32 6 6 CD cord-007277-86lynlxn 43 33 ] ] -RRB- cord-007277-86lynlxn 43 34 . . . cord-007277-86lynlxn 44 1 Third third JJ cord-007277-86lynlxn 44 2 , , , cord-007277-86lynlxn 44 3 and and CC cord-007277-86lynlxn 44 4 more more RBR cord-007277-86lynlxn 44 5 recently recently RB cord-007277-86lynlxn 44 6 , , , cord-007277-86lynlxn 44 7 there there EX cord-007277-86lynlxn 44 8 has have VBZ cord-007277-86lynlxn 44 9 been be VBN cord-007277-86lynlxn 44 10 evidence evidence NN cord-007277-86lynlxn 44 11 from from IN cord-007277-86lynlxn 44 12 molecular molecular JJ cord-007277-86lynlxn 44 13 immunopathologic immunopathologic JJ cord-007277-86lynlxn 44 14 studies study NNS cord-007277-86lynlxn 44 15 by by IN cord-007277-86lynlxn 44 16 Rowley Rowley NNP cord-007277-86lynlxn 44 17 et et NNP cord-007277-86lynlxn 44 18 al al NNP cord-007277-86lynlxn 44 19 . . . cord-007277-86lynlxn 45 1 indicating indicate VBG cord-007277-86lynlxn 45 2 that that IN cord-007277-86lynlxn 45 3 , , , cord-007277-86lynlxn 45 4 during during IN cord-007277-86lynlxn 45 5 Kawasaki Kawasaki NNP cord-007277-86lynlxn 45 6 disease disease NN cord-007277-86lynlxn 45 7 , , , cord-007277-86lynlxn 45 8 some some DT cord-007277-86lynlxn 45 9 external external JJ cord-007277-86lynlxn 45 10 agent agent NN cord-007277-86lynlxn 45 11 triggers trigger VBZ cord-007277-86lynlxn 45 12 a a DT cord-007277-86lynlxn 45 13 powerful powerful JJ cord-007277-86lynlxn 45 14 IgA IgA NNP cord-007277-86lynlxn 45 15 response response NN cord-007277-86lynlxn 45 16 in in IN cord-007277-86lynlxn 45 17 the the DT cord-007277-86lynlxn 45 18 respiratory respiratory JJ cord-007277-86lynlxn 45 19 tract tract NN cord-007277-86lynlxn 45 20 as as RB cord-007277-86lynlxn 45 21 well well RB cord-007277-86lynlxn 45 22 as as IN cord-007277-86lynlxn 45 23 in in IN cord-007277-86lynlxn 45 24 other other JJ cord-007277-86lynlxn 45 25 organs organ NNS cord-007277-86lynlxn 45 26 ( ( -LRB- cord-007277-86lynlxn 45 27 including include VBG cord-007277-86lynlxn 45 28 medium medium JJ cord-007277-86lynlxn 45 29 and and CC cord-007277-86lynlxn 45 30 large large JJ cord-007277-86lynlxn 45 31 muscular muscular JJ cord-007277-86lynlxn 45 32 arteries artery NNS cord-007277-86lynlxn 45 33 ) ) -RRB- cord-007277-86lynlxn 45 34 , , , cord-007277-86lynlxn 45 35 suggesting suggest VBG cord-007277-86lynlxn 45 36 that that IN cord-007277-86lynlxn 45 37 the the DT cord-007277-86lynlxn 45 38 target target NN cord-007277-86lynlxn 45 39 of of IN cord-007277-86lynlxn 45 40 the the DT cord-007277-86lynlxn 45 41 extensive extensive JJ cord-007277-86lynlxn 45 42 immunologic immunologic JJ cord-007277-86lynlxn 45 43 reaction reaction NN cord-007277-86lynlxn 45 44 during during IN cord-007277-86lynlxn 45 45 Kawasaki Kawasaki NNP cord-007277-86lynlxn 45 46 disease disease NN cord-007277-86lynlxn 45 47 is be VBZ cord-007277-86lynlxn 45 48 a a DT cord-007277-86lynlxn 45 49 specific specific JJ cord-007277-86lynlxn 45 50 microbe microbe NN cord-007277-86lynlxn 45 51 ( ( -LRB- cord-007277-86lynlxn 45 52 rather rather RB cord-007277-86lynlxn 45 53 than than IN cord-007277-86lynlxn 45 54 an an DT cord-007277-86lynlxn 45 55 nonspecific nonspecific JJ cord-007277-86lynlxn 45 56 stimulus stimulus NN cord-007277-86lynlxn 45 57 , , , cord-007277-86lynlxn 45 58 such such JJ cord-007277-86lynlxn 45 59 as as IN cord-007277-86lynlxn 45 60 a a DT cord-007277-86lynlxn 45 61 superantigen superantigen NN cord-007277-86lynlxn 45 62 ) ) -RRB- cord-007277-86lynlxn 45 63 and and CC cord-007277-86lynlxn 45 64 that that IN cord-007277-86lynlxn 45 65 this this DT cord-007277-86lynlxn 45 66 microbe microbe NN cord-007277-86lynlxn 45 67 enters enter VBZ cord-007277-86lynlxn 45 68 the the DT cord-007277-86lynlxn 45 69 body body NN cord-007277-86lynlxn 45 70 through through IN cord-007277-86lynlxn 45 71 the the DT cord-007277-86lynlxn 45 72 respiratory respiratory JJ cord-007277-86lynlxn 45 73 tract tract NN cord-007277-86lynlxn 45 74 [ [ -LRB- cord-007277-86lynlxn 45 75 26 26 CD cord-007277-86lynlxn 45 76 ] ] -RRB- cord-007277-86lynlxn 45 77 [ [ -LRB- cord-007277-86lynlxn 45 78 27 27 CD cord-007277-86lynlxn 45 79 ] ] -RRB- cord-007277-86lynlxn 45 80 [ [ -LRB- cord-007277-86lynlxn 45 81 28 28 CD cord-007277-86lynlxn 45 82 ] ] -RRB- cord-007277-86lynlxn 45 83 . . . cord-007277-86lynlxn 46 1 If if IN cord-007277-86lynlxn 46 2 this this DT cord-007277-86lynlxn 46 3 is be VBZ cord-007277-86lynlxn 46 4 , , , cord-007277-86lynlxn 46 5 in in IN cord-007277-86lynlxn 46 6 fact fact NN cord-007277-86lynlxn 46 7 , , , cord-007277-86lynlxn 46 8 the the DT cord-007277-86lynlxn 46 9 case case NN cord-007277-86lynlxn 46 10 , , , cord-007277-86lynlxn 46 11 then then RB cord-007277-86lynlxn 46 12 a a DT cord-007277-86lynlxn 46 13 respiratory respiratory JJ cord-007277-86lynlxn 46 14 HCoV hcov NN cord-007277-86lynlxn 46 15 might may MD cord-007277-86lynlxn 46 16 be be VB cord-007277-86lynlxn 46 17 the the DT cord-007277-86lynlxn 46 18 inciting incite VBG cord-007277-86lynlxn 46 19 agent agent NN cord-007277-86lynlxn 46 20 . . . cord-007277-86lynlxn 47 1 Fourth fourth RB cord-007277-86lynlxn 47 2 , , , cord-007277-86lynlxn 47 3 the the DT cord-007277-86lynlxn 47 4 SARS SARS NNP cord-007277-86lynlxn 47 5 story story NN cord-007277-86lynlxn 47 6 reminds remind VBZ cord-007277-86lynlxn 47 7 us -PRON- PRP cord-007277-86lynlxn 47 8 of of IN cord-007277-86lynlxn 47 9 what what WP cord-007277-86lynlxn 47 10 veterinarian veterinarian NN cord-007277-86lynlxn 47 11 virologists virologist NNS cord-007277-86lynlxn 47 12 have have VBP cord-007277-86lynlxn 47 13 known know VBN cord-007277-86lynlxn 47 14 for for IN cord-007277-86lynlxn 47 15 many many JJ cord-007277-86lynlxn 47 16 years year NNS cord-007277-86lynlxn 47 17 : : : cord-007277-86lynlxn 47 18 that that IN cord-007277-86lynlxn 47 19 CoVs CoVs NNP cord-007277-86lynlxn 47 20 , , , cord-007277-86lynlxn 47 21 with with IN cord-007277-86lynlxn 47 22 their -PRON- PRP$ cord-007277-86lynlxn 47 23 huge huge JJ cord-007277-86lynlxn 47 24 genome genome NN cord-007277-86lynlxn 47 25 , , , cord-007277-86lynlxn 47 26 are be VBP cord-007277-86lynlxn 47 27 capable capable JJ cord-007277-86lynlxn 47 28 of of IN cord-007277-86lynlxn 47 29 enormously enormously RB cord-007277-86lynlxn 47 30 varied varied JJ cord-007277-86lynlxn 47 31 pathogenicity pathogenicity NN cord-007277-86lynlxn 47 32 , , , cord-007277-86lynlxn 47 33 causing cause VBG cord-007277-86lynlxn 47 34 diseases disease NNS cord-007277-86lynlxn 47 35 that that WDT cord-007277-86lynlxn 47 36 affect affect VBP cord-007277-86lynlxn 47 37 multiple multiple JJ cord-007277-86lynlxn 47 38 organs organ NNS cord-007277-86lynlxn 47 39 through through IN cord-007277-86lynlxn 47 40 a a DT cord-007277-86lynlxn 47 41 variety variety NN cord-007277-86lynlxn 47 42 of of IN cord-007277-86lynlxn 47 43 pathogenetic pathogenetic JJ cord-007277-86lynlxn 47 44 mechanisms mechanism NNS cord-007277-86lynlxn 47 45 . . . cord-007277-86lynlxn 48 1 Also also RB cord-007277-86lynlxn 48 2 , , , cord-007277-86lynlxn 48 3 SARS SARS NNP cord-007277-86lynlxn 48 4 - - HYPH cord-007277-86lynlxn 48 5 CoV CoV NNP cord-007277-86lynlxn 48 6 crossed cross VBD cord-007277-86lynlxn 48 7 species species NN cord-007277-86lynlxn 48 8 lines line NNS cord-007277-86lynlxn 48 9 and and CC cord-007277-86lynlxn 48 10 was be VBD cord-007277-86lynlxn 48 11 genetically genetically RB cord-007277-86lynlxn 48 12 quite quite RB cord-007277-86lynlxn 48 13 distant distant JJ cord-007277-86lynlxn 48 14 from from IN cord-007277-86lynlxn 48 15 the the DT cord-007277-86lynlxn 48 16 3 3 CD cord-007277-86lynlxn 48 17 known know VBN cord-007277-86lynlxn 48 18 CoV cov NN cord-007277-86lynlxn 48 19 groups group NNS cord-007277-86lynlxn 48 20 , , , cord-007277-86lynlxn 48 21 whereas whereas IN cord-007277-86lynlxn 48 22 HCoV HCoV NNP cord-007277-86lynlxn 48 23 - - HYPH cord-007277-86lynlxn 48 24 NH NH NNP cord-007277-86lynlxn 48 25 ( ( -LRB- cord-007277-86lynlxn 48 26 along along IN cord-007277-86lynlxn 48 27 with with IN cord-007277-86lynlxn 48 28 its -PRON- PRP$ cord-007277-86lynlxn 48 29 companion companion NN cord-007277-86lynlxn 48 30 novel novel NN cord-007277-86lynlxn 48 31 virus virus NN cord-007277-86lynlxn 48 32 reported report VBN cord-007277-86lynlxn 48 33 in in IN cord-007277-86lynlxn 48 34 The the DT cord-007277-86lynlxn 48 35 Netherlands Netherlands NNP cord-007277-86lynlxn 48 36 ) ) -RRB- cord-007277-86lynlxn 48 37 appears appear VBZ cord-007277-86lynlxn 48 38 to to TO cord-007277-86lynlxn 48 39 be be VB cord-007277-86lynlxn 48 40 a a DT cord-007277-86lynlxn 48 41 member member NN cord-007277-86lynlxn 48 42 of of IN cord-007277-86lynlxn 48 43 the the DT cord-007277-86lynlxn 48 44 group group NN cord-007277-86lynlxn 48 45 1 1 CD cord-007277-86lynlxn 48 46 CoVs CoVs NNP cord-007277-86lynlxn 48 47 and and CC cord-007277-86lynlxn 48 48 has have VBZ cord-007277-86lynlxn 48 49 other other JJ cord-007277-86lynlxn 48 50 features feature NNS cord-007277-86lynlxn 48 51 that that WDT cord-007277-86lynlxn 48 52 make make VBP cord-007277-86lynlxn 48 53 it -PRON- PRP cord-007277-86lynlxn 48 54 appear appear VB cord-007277-86lynlxn 48 55 to to TO cord-007277-86lynlxn 48 56 be be VB cord-007277-86lynlxn 48 57 closer close JJR cord-007277-86lynlxn 48 58 to to IN cord-007277-86lynlxn 48 59 HCoV-229E HCoV-229E NNP cord-007277-86lynlxn 48 60 and and CC cord-007277-86lynlxn 48 61 HCoV HCoV NNP cord-007277-86lynlxn 48 62 - - HYPH cord-007277-86lynlxn 48 63 OC43 OC43 NNP cord-007277-86lynlxn 48 64 in in IN cord-007277-86lynlxn 48 65 its -PRON- PRP$ cord-007277-86lynlxn 48 66 pathogenicity pathogenicity NN cord-007277-86lynlxn 48 67 [ [ -LRB- cord-007277-86lynlxn 48 68 13 13 CD cord-007277-86lynlxn 48 69 ] ] -RRB- cord-007277-86lynlxn 48 70 . . . cord-007277-86lynlxn 49 1 If if IN cord-007277-86lynlxn 49 2 HCoV HCoV NNP cord-007277-86lynlxn 49 3 - - HYPH cord-007277-86lynlxn 49 4 NH NH NNP cord-007277-86lynlxn 49 5 is be VBZ cord-007277-86lynlxn 49 6 , , , cord-007277-86lynlxn 49 7 in in IN cord-007277-86lynlxn 49 8 fact fact NN cord-007277-86lynlxn 49 9 , , , cord-007277-86lynlxn 49 10 the the DT cord-007277-86lynlxn 49 11 agent agent NN cord-007277-86lynlxn 49 12 responsible responsible JJ cord-007277-86lynlxn 49 13 for for IN cord-007277-86lynlxn 49 14 Kawasaki Kawasaki NNP cord-007277-86lynlxn 49 15 disease disease NN cord-007277-86lynlxn 49 16 and and CC cord-007277-86lynlxn 49 17 is be VBZ cord-007277-86lynlxn 49 18 acting act VBG cord-007277-86lynlxn 49 19 alone alone RB cord-007277-86lynlxn 49 20 , , , cord-007277-86lynlxn 49 21 then then RB cord-007277-86lynlxn 49 22 we -PRON- PRP cord-007277-86lynlxn 49 23 have have VBP cord-007277-86lynlxn 49 24 to to TO cord-007277-86lynlxn 49 25 postulate postulate VB cord-007277-86lynlxn 49 26 that that IN cord-007277-86lynlxn 49 27 it -PRON- PRP cord-007277-86lynlxn 49 28 has have VBZ cord-007277-86lynlxn 49 29 acquired acquire VBN cord-007277-86lynlxn 49 30 a a DT cord-007277-86lynlxn 49 31 pathogenicity pathogenicity NN cord-007277-86lynlxn 49 32 that that WDT cord-007277-86lynlxn 49 33 is be VBZ cord-007277-86lynlxn 49 34 quite quite RB cord-007277-86lynlxn 49 35 different different JJ cord-007277-86lynlxn 49 36 from from IN cord-007277-86lynlxn 49 37 that that DT cord-007277-86lynlxn 49 38 of of IN cord-007277-86lynlxn 49 39 its -PRON- PRP$ cord-007277-86lynlxn 49 40 close close JJ cord-007277-86lynlxn 49 41 relatives relative NNS cord-007277-86lynlxn 49 42 and and CC cord-007277-86lynlxn 49 43 of of IN cord-007277-86lynlxn 49 44 other other JJ cord-007277-86lynlxn 49 45 respiratory respiratory JJ cord-007277-86lynlxn 49 46 viruses virus NNS cord-007277-86lynlxn 49 47 . . . cord-007277-86lynlxn 50 1 Clearly clearly RB cord-007277-86lynlxn 50 2 , , , cord-007277-86lynlxn 50 3 a a DT cord-007277-86lynlxn 50 4 lot lot NN cord-007277-86lynlxn 50 5 more more JJR cord-007277-86lynlxn 50 6 work work NN cord-007277-86lynlxn 50 7 needs need VBZ cord-007277-86lynlxn 50 8 to to TO cord-007277-86lynlxn 50 9 be be VB cord-007277-86lynlxn 50 10 done do VBN cord-007277-86lynlxn 50 11 . . . cord-007277-86lynlxn 51 1 Because because IN cord-007277-86lynlxn 51 2 Esper Esper NNP cord-007277-86lynlxn 51 3 et et NNP cord-007277-86lynlxn 51 4 al al NNP cord-007277-86lynlxn 51 5 . . NNP cord-007277-86lynlxn 51 6 's 's POS cord-007277-86lynlxn 51 7 study study NN cord-007277-86lynlxn 51 8 of of IN cord-007277-86lynlxn 51 9 Kawasaki Kawasaki NNP cord-007277-86lynlxn 51 10 disease disease NN cord-007277-86lynlxn 51 11 was be VBD cord-007277-86lynlxn 51 12 epidemiologic epidemiologic JJ cord-007277-86lynlxn 51 13 , , , cord-007277-86lynlxn 51 14 confirmation confirmation NN cord-007277-86lynlxn 51 15 in in IN cord-007277-86lynlxn 51 16 broader broad JJR cord-007277-86lynlxn 51 17 epidemiologic epidemiologic JJ cord-007277-86lynlxn 51 18 terms term NNS cord-007277-86lynlxn 51 19 ( ( -LRB- cord-007277-86lynlxn 51 20 other other JJ cord-007277-86lynlxn 51 21 places place NNS cord-007277-86lynlxn 51 22 , , , cord-007277-86lynlxn 51 23 other other JJ cord-007277-86lynlxn 51 24 times time NNS cord-007277-86lynlxn 51 25 , , , cord-007277-86lynlxn 51 26 other other JJ cord-007277-86lynlxn 51 27 detection detection NN cord-007277-86lynlxn 51 28 methods method NNS cord-007277-86lynlxn 51 29 , , , cord-007277-86lynlxn 51 30 other other JJ cord-007277-86lynlxn 51 31 populations population NNS cord-007277-86lynlxn 51 32 ) ) -RRB- cord-007277-86lynlxn 51 33 is be VBZ cord-007277-86lynlxn 51 34 required require VBN cord-007277-86lynlxn 51 35 , , , cord-007277-86lynlxn 51 36 as as IN cord-007277-86lynlxn 51 37 is be VBZ cord-007277-86lynlxn 51 38 nonepidemiologic nonepidemiologic JJ cord-007277-86lynlxn 51 39 confirmation confirmation NN cord-007277-86lynlxn 51 40 through through IN cord-007277-86lynlxn 51 41 the the DT cord-007277-86lynlxn 51 42 demonstration demonstration NN cord-007277-86lynlxn 51 43 of of IN cord-007277-86lynlxn 51 44 an an DT cord-007277-86lynlxn 51 45 immunologic immunologic JJ cord-007277-86lynlxn 51 46 response response NN cord-007277-86lynlxn 51 47 to to IN cord-007277-86lynlxn 51 48 HCoV HCoV NNP cord-007277-86lynlxn 51 49 - - HYPH cord-007277-86lynlxn 51 50 NH NH NNP cord-007277-86lynlxn 51 51 and and CC cord-007277-86lynlxn 51 52 of of IN cord-007277-86lynlxn 51 53 its -PRON- PRP$ cord-007277-86lynlxn 51 54 presence presence NN cord-007277-86lynlxn 51 55 in in IN cord-007277-86lynlxn 51 56 biopsy biopsy NN cord-007277-86lynlxn 51 57 specimens specimen NNS cord-007277-86lynlxn 51 58 . . . cord-007277-86lynlxn 52 1 If if IN cord-007277-86lynlxn 52 2 the the DT cord-007277-86lynlxn 52 3 association association NN cord-007277-86lynlxn 52 4 is be VBZ cord-007277-86lynlxn 52 5 confirmed confirm VBN cord-007277-86lynlxn 52 6 , , , cord-007277-86lynlxn 52 7 then then RB cord-007277-86lynlxn 52 8 the the DT cord-007277-86lynlxn 52 9 pathophysiologic pathophysiologic NN cord-007277-86lynlxn 52 10 mechanism mechanism NN cord-007277-86lynlxn 52 11 will will MD cord-007277-86lynlxn 52 12 need need VB cord-007277-86lynlxn 52 13 to to TO cord-007277-86lynlxn 52 14 be be VB cord-007277-86lynlxn 52 15 further further RB cord-007277-86lynlxn 52 16 worked work VBN cord-007277-86lynlxn 52 17 out out RP cord-007277-86lynlxn 52 18 . . . cord-007277-86lynlxn 53 1 Kawasaki Kawasaki NNP cord-007277-86lynlxn 53 2 disease disease NN cord-007277-86lynlxn 53 3 has have VBZ cord-007277-86lynlxn 53 4 a a DT cord-007277-86lynlxn 53 5 complex complex JJ cord-007277-86lynlxn 53 6 pathogenesis pathogenesis NN cord-007277-86lynlxn 53 7 and and CC cord-007277-86lynlxn 53 8 has have VBZ cord-007277-86lynlxn 53 9 been be VBN cord-007277-86lynlxn 53 10 the the DT cord-007277-86lynlxn 53 11 subject subject NN cord-007277-86lynlxn 53 12 of of IN cord-007277-86lynlxn 53 13 much much JJ cord-007277-86lynlxn 53 14 study study NN cord-007277-86lynlxn 53 15 by by IN cord-007277-86lynlxn 53 16 microbiologists microbiologist NNS cord-007277-86lynlxn 53 17 , , , cord-007277-86lynlxn 53 18 immunologists immunologist NNS cord-007277-86lynlxn 53 19 , , , cord-007277-86lynlxn 53 20 rheumatologists rheumatologist NNS cord-007277-86lynlxn 53 21 , , , cord-007277-86lynlxn 53 22 cardiologists cardiologist NNS cord-007277-86lynlxn 53 23 , , , cord-007277-86lynlxn 53 24 and and CC cord-007277-86lynlxn 53 25 molecular molecular JJ cord-007277-86lynlxn 53 26 biologists biologist NNS cord-007277-86lynlxn 53 27 [ [ -LRB- cord-007277-86lynlxn 53 28 29 29 CD cord-007277-86lynlxn 53 29 ] ] -RRB- cord-007277-86lynlxn 53 30 . . . cord-007277-86lynlxn 54 1 Much much JJ cord-007277-86lynlxn 54 2 is be VBZ cord-007277-86lynlxn 54 3 known know VBN cord-007277-86lynlxn 54 4 about about IN cord-007277-86lynlxn 54 5 many many JJ cord-007277-86lynlxn 54 6 of of IN cord-007277-86lynlxn 54 7 the the DT cord-007277-86lynlxn 54 8 mechanisms mechanism NNS cord-007277-86lynlxn 54 9 of of IN cord-007277-86lynlxn 54 10 Kawasaki Kawasaki NNP cord-007277-86lynlxn 54 11 disease disease NN cord-007277-86lynlxn 54 12 , , , cord-007277-86lynlxn 54 13 and and CC cord-007277-86lynlxn 54 14 in in IN cord-007277-86lynlxn 54 15 some some DT cord-007277-86lynlxn 54 16 way way NN cord-007277-86lynlxn 54 17 these these DT cord-007277-86lynlxn 54 18 must must MD cord-007277-86lynlxn 54 19 be be VB cord-007277-86lynlxn 54 20 linked link VBN cord-007277-86lynlxn 54 21 to to IN cord-007277-86lynlxn 54 22 the the DT cord-007277-86lynlxn 54 23 presumed presume VBN cord-007277-86lynlxn 54 24 microbial microbial JJ cord-007277-86lynlxn 54 25 etiology etiology NN cord-007277-86lynlxn 54 26 . . . cord-007277-86lynlxn 55 1 A a DT cord-007277-86lynlxn 55 2 broad broad JJ cord-007277-86lynlxn 55 3 question question NN cord-007277-86lynlxn 55 4 would would MD cord-007277-86lynlxn 55 5 be be VB cord-007277-86lynlxn 55 6 : : : cord-007277-86lynlxn 55 7 Is be VBZ cord-007277-86lynlxn 55 8 the the DT cord-007277-86lynlxn 55 9 pathogenesis pathogenesis NN cord-007277-86lynlxn 55 10 of of IN cord-007277-86lynlxn 55 11 Kawasaki Kawasaki NNP cord-007277-86lynlxn 55 12 disease disease NN cord-007277-86lynlxn 55 13 the the DT cord-007277-86lynlxn 55 14 product product NN cord-007277-86lynlxn 55 15 of of IN cord-007277-86lynlxn 55 16 HCoV HCoV NNP cord-007277-86lynlxn 55 17 - - HYPH cord-007277-86lynlxn 55 18 NH NH NNP cord-007277-86lynlxn 55 19 infection infection NN cord-007277-86lynlxn 55 20 by by IN cord-007277-86lynlxn 55 21 itself -PRON- PRP cord-007277-86lynlxn 55 22 ? ? . cord-007277-86lynlxn 56 1 There there EX cord-007277-86lynlxn 56 2 are be VBP cord-007277-86lynlxn 56 3 several several JJ cord-007277-86lynlxn 56 4 animal animal NN cord-007277-86lynlxn 56 5 CoV cov NN cord-007277-86lynlxn 56 6 diseases disease NNS cord-007277-86lynlxn 56 7 that that WDT cord-007277-86lynlxn 56 8 are be VBP cord-007277-86lynlxn 56 9 models model NNS cord-007277-86lynlxn 56 10 of of IN cord-007277-86lynlxn 56 11 complex complex JJ cord-007277-86lynlxn 56 12 pathophysiologic pathophysiologic NN cord-007277-86lynlxn 56 13 mechanisms mechanism NNS cord-007277-86lynlxn 56 14 - - : cord-007277-86lynlxn 56 15 the the DT cord-007277-86lynlxn 56 16 multiple multiple JJ cord-007277-86lynlxn 56 17 sclerosis sclerosis NN cord-007277-86lynlxn 56 18 - - HYPH cord-007277-86lynlxn 56 19 like like JJ cord-007277-86lynlxn 56 20 disease disease NN cord-007277-86lynlxn 56 21 of of IN cord-007277-86lynlxn 56 22 mice mouse NNS cord-007277-86lynlxn 56 23 caused cause VBN cord-007277-86lynlxn 56 24 by by IN cord-007277-86lynlxn 56 25 certain certain JJ cord-007277-86lynlxn 56 26 neurogenic neurogenic JJ cord-007277-86lynlxn 56 27 strains strain NNS cord-007277-86lynlxn 56 28 of of IN cord-007277-86lynlxn 56 29 mouse mouse NN cord-007277-86lynlxn 56 30 hepatitis hepatitis NN cord-007277-86lynlxn 56 31 virus virus NN cord-007277-86lynlxn 56 32 [ [ -LRB- cord-007277-86lynlxn 56 33 30 30 CD cord-007277-86lynlxn 56 34 ] ] -RRB- cord-007277-86lynlxn 56 35 and and CC cord-007277-86lynlxn 56 36 the the DT cord-007277-86lynlxn 56 37 complex complex JJ cord-007277-86lynlxn 56 38 , , , cord-007277-86lynlxn 56 39 immunologically immunologically RB cord-007277-86lynlxn 56 40 mediated mediate VBN cord-007277-86lynlxn 56 41 , , , cord-007277-86lynlxn 56 42 progressive progressive JJ cord-007277-86lynlxn 56 43 feline feline JJ cord-007277-86lynlxn 56 44 peritonitis peritonitis NN cord-007277-86lynlxn 56 45 caused cause VBN cord-007277-86lynlxn 56 46 by by IN cord-007277-86lynlxn 56 47 the the DT cord-007277-86lynlxn 56 48 CoV cov NN cord-007277-86lynlxn 56 49 of of IN cord-007277-86lynlxn 56 50 that that DT cord-007277-86lynlxn 56 51 name name NN cord-007277-86lynlxn 56 52 [ [ -LRB- cord-007277-86lynlxn 56 53 31 31 CD cord-007277-86lynlxn 56 54 ] ] -RRB- cord-007277-86lynlxn 56 55 , , , cord-007277-86lynlxn 56 56 for for IN cord-007277-86lynlxn 56 57 example example NN cord-007277-86lynlxn 56 58 . . . cord-007277-86lynlxn 57 1 In in IN cord-007277-86lynlxn 57 2 these these DT cord-007277-86lynlxn 57 3 diseases disease NNS cord-007277-86lynlxn 57 4 , , , cord-007277-86lynlxn 57 5 genetics genetic NNS cord-007277-86lynlxn 57 6 , , , cord-007277-86lynlxn 57 7 the the DT cord-007277-86lynlxn 57 8 immune immune JJ cord-007277-86lynlxn 57 9 system system NN cord-007277-86lynlxn 57 10 , , , cord-007277-86lynlxn 57 11 and and CC cord-007277-86lynlxn 57 12 the the DT cord-007277-86lynlxn 57 13 complex complex JJ cord-007277-86lynlxn 57 14 CoV cov NN cord-007277-86lynlxn 57 15 genome genome NN cord-007277-86lynlxn 57 16 all all DT cord-007277-86lynlxn 57 17 interact interact VBP cord-007277-86lynlxn 57 18 . . . cord-007277-86lynlxn 58 1 Alternatively alternatively RB cord-007277-86lynlxn 58 2 , , , cord-007277-86lynlxn 58 3 might may MD cord-007277-86lynlxn 58 4 there there EX cord-007277-86lynlxn 58 5 be be VB cord-007277-86lynlxn 58 6 another another DT cord-007277-86lynlxn 58 7 microbial microbial JJ cord-007277-86lynlxn 58 8 pathogen pathogen NN cord-007277-86lynlxn 58 9 involved involve VBN cord-007277-86lynlxn 58 10 in in IN cord-007277-86lynlxn 58 11 the the DT cord-007277-86lynlxn 58 12 pathogenesis pathogenesis NN cord-007277-86lynlxn 58 13 of of IN cord-007277-86lynlxn 58 14 Kawasaki Kawasaki NNP cord-007277-86lynlxn 58 15 disease disease NN cord-007277-86lynlxn 58 16 , , , cord-007277-86lynlxn 58 17 such such JJ cord-007277-86lynlxn 58 18 that that IN cord-007277-86lynlxn 58 19 it -PRON- PRP cord-007277-86lynlxn 58 20 is be VBZ cord-007277-86lynlxn 58 21 a a DT cord-007277-86lynlxn 58 22 2-hit 2-hit JJ cord-007277-86lynlxn 58 23 disease disease NN cord-007277-86lynlxn 58 24 requiring require VBG cord-007277-86lynlxn 58 25 both both CC cord-007277-86lynlxn 58 26 a a DT cord-007277-86lynlxn 58 27 virus virus NN cord-007277-86lynlxn 58 28 and and CC cord-007277-86lynlxn 58 29 a a DT cord-007277-86lynlxn 58 30 toxin toxin NN cord-007277-86lynlxn 58 31 ? ? . cord-007277-86lynlxn 59 1 We -PRON- PRP cord-007277-86lynlxn 59 2 will will MD cord-007277-86lynlxn 59 3 watch watch VB cord-007277-86lynlxn 59 4 this this DT cord-007277-86lynlxn 59 5 field field NN cord-007277-86lynlxn 59 6 with with IN cord-007277-86lynlxn 59 7 great great JJ cord-007277-86lynlxn 59 8 interest interest NN cord-007277-86lynlxn 59 9 . . . cord-007277-86lynlxn 60 1 Cultivation cultivation NN cord-007277-86lynlxn 60 2 of of IN cord-007277-86lynlxn 60 3 a a DT cord-007277-86lynlxn 60 4 novel novel JJ cord-007277-86lynlxn 60 5 type type NN cord-007277-86lynlxn 60 6 of of IN cord-007277-86lynlxn 60 7 common common JJ cord-007277-86lynlxn 60 8 - - HYPH cord-007277-86lynlxn 60 9 cold cold JJ cord-007277-86lynlxn 60 10 virus virus NN cord-007277-86lynlxn 60 11 in in IN cord-007277-86lynlxn 60 12 organ organ NN cord-007277-86lynlxn 60 13 cultures culture NNS cord-007277-86lynlxn 60 14 Effects effect NNS cord-007277-86lynlxn 60 15 of of IN cord-007277-86lynlxn 60 16 a a DT cord-007277-86lynlxn 60 17 " " `` cord-007277-86lynlxn 60 18 new new JJ cord-007277-86lynlxn 60 19 " " '' cord-007277-86lynlxn 60 20 human human JJ cord-007277-86lynlxn 60 21 respiratory respiratory JJ cord-007277-86lynlxn 60 22 virus virus NN cord-007277-86lynlxn 60 23 in in IN cord-007277-86lynlxn 60 24 volunteers volunteer NNS cord-007277-86lynlxn 60 25 Coronative Coronative NNP cord-007277-86lynlxn 60 26 antibody antibody NN cord-007277-86lynlxn 60 27 titres titre NNS cord-007277-86lynlxn 60 28 in in IN cord-007277-86lynlxn 60 29 sera sera NNP cord-007277-86lynlxn 60 30 of of IN cord-007277-86lynlxn 60 31 healthy healthy JJ cord-007277-86lynlxn 60 32 adults adult NNS cord-007277-86lynlxn 60 33 and and CC cord-007277-86lynlxn 60 34 experimentally experimentally RB cord-007277-86lynlxn 60 35 infected infect VBN cord-007277-86lynlxn 60 36 volunteers volunteer NNS cord-007277-86lynlxn 60 37 Virologic Virologic NNP cord-007277-86lynlxn 60 38 studies study NNS cord-007277-86lynlxn 60 39 of of IN cord-007277-86lynlxn 60 40 acute acute JJ cord-007277-86lynlxn 60 41 respiratory respiratory JJ cord-007277-86lynlxn 60 42 disease disease NN cord-007277-86lynlxn 60 43 in in IN cord-007277-86lynlxn 60 44 young young JJ cord-007277-86lynlxn 60 45 adults adult NNS cord-007277-86lynlxn 60 46 . . . cord-007277-86lynlxn 61 1 V. V. NNP cord-007277-86lynlxn 61 2 Coronavirus Coronavirus NNP cord-007277-86lynlxn 61 3 229E 229e CD cord-007277-86lynlxn 61 4 infections infection NNS cord-007277-86lynlxn 61 5 during during IN cord-007277-86lynlxn 61 6 six six CD cord-007277-86lynlxn 61 7 years year NNS cord-007277-86lynlxn 61 8 of of IN cord-007277-86lynlxn 61 9 surveillance surveillance NN cord-007277-86lynlxn 61 10 Seroepidemiologic Seroepidemiologic NNP cord-007277-86lynlxn 61 11 studies study NNS cord-007277-86lynlxn 61 12 of of IN cord-007277-86lynlxn 61 13 coronavirus coronavirus NN cord-007277-86lynlxn 61 14 infection infection NN cord-007277-86lynlxn 61 15 in in IN cord-007277-86lynlxn 61 16 adults adult NNS cord-007277-86lynlxn 61 17 and and CC cord-007277-86lynlxn 61 18 children child NNS cord-007277-86lynlxn 62 1 The the DT cord-007277-86lynlxn 62 2 Tecumseh Tecumseh NNP cord-007277-86lynlxn 62 3 study study NN cord-007277-86lynlxn 62 4 of of IN cord-007277-86lynlxn 62 5 respiratory respiratory JJ cord-007277-86lynlxn 62 6 illness illness NN cord-007277-86lynlxn 62 7 . . . cord-007277-86lynlxn 63 1 VI VI NNP cord-007277-86lynlxn 63 2 . . . cord-007277-86lynlxn 64 1 Frequency frequency NN cord-007277-86lynlxn 64 2 of of IN cord-007277-86lynlxn 64 3 and and CC cord-007277-86lynlxn 64 4 relationship relationship NN cord-007277-86lynlxn 64 5 between between IN cord-007277-86lynlxn 64 6 outbreaks outbreak NNS cord-007277-86lynlxn 64 7 of of IN cord-007277-86lynlxn 64 8 coronavirus coronavirus NN cord-007277-86lynlxn 64 9 infection infection NN cord-007277-86lynlxn 64 10 Association Association NNP cord-007277-86lynlxn 64 11 of of IN cord-007277-86lynlxn 64 12 coronavirus coronavirus NN cord-007277-86lynlxn 64 13 infection infection NN cord-007277-86lynlxn 64 14 with with IN cord-007277-86lynlxn 64 15 neonatal neonatal JJ cord-007277-86lynlxn 64 16 necrotizing necrotize VBG cord-007277-86lynlxn 64 17 enterocolitis enterocolitis NN cord-007277-86lynlxn 64 18 Coronaviridae Coronaviridae NNP cord-007277-86lynlxn 64 19 : : : cord-007277-86lynlxn 65 1 the the DT cord-007277-86lynlxn 65 2 viruses virus NNS cord-007277-86lynlxn 65 3 and and CC cord-007277-86lynlxn 65 4 their -PRON- PRP$ cord-007277-86lynlxn 65 5 replication replication NN cord-007277-86lynlxn 66 1 The the DT cord-007277-86lynlxn 66 2 Chinese chinese JJ cord-007277-86lynlxn 66 3 SARS SARS NNP cord-007277-86lynlxn 66 4 Molecular Molecular NNP cord-007277-86lynlxn 66 5 Epidemiology Epidemiology NNP cord-007277-86lynlxn 66 6 Consortium Consortium NNP cord-007277-86lynlxn 66 7 . . . cord-007277-86lynlxn 67 1 Molecular molecular JJ cord-007277-86lynlxn 67 2 evolution evolution NN cord-007277-86lynlxn 67 3 of of IN cord-007277-86lynlxn 67 4 the the DT cord-007277-86lynlxn 67 5 SARS SARS NNP cord-007277-86lynlxn 67 6 coronavirus coronavirus NN cord-007277-86lynlxn 67 7 during during IN cord-007277-86lynlxn 67 8 the the DT cord-007277-86lynlxn 67 9 course course NN cord-007277-86lynlxn 67 10 of of IN cord-007277-86lynlxn 67 11 the the DT cord-007277-86lynlxn 67 12 SARS SARS NNP cord-007277-86lynlxn 67 13 epidemic epidemic NN cord-007277-86lynlxn 67 14 in in IN cord-007277-86lynlxn 67 15 China China NNP cord-007277-86lynlxn 68 1 The the DT cord-007277-86lynlxn 68 2 severe severe JJ cord-007277-86lynlxn 68 3 acute acute JJ cord-007277-86lynlxn 68 4 respiratory respiratory JJ cord-007277-86lynlxn 68 5 syndrome syndrome NN cord-007277-86lynlxn 68 6 Evidence evidence NN cord-007277-86lynlxn 68 7 of of IN cord-007277-86lynlxn 68 8 a a DT cord-007277-86lynlxn 68 9 novel novel JJ cord-007277-86lynlxn 68 10 human human JJ cord-007277-86lynlxn 68 11 coronavirus coronavirus NN cord-007277-86lynlxn 68 12 that that WDT cord-007277-86lynlxn 68 13 is be VBZ cord-007277-86lynlxn 68 14 associated associate VBN cord-007277-86lynlxn 68 15 with with IN cord-007277-86lynlxn 68 16 respiratory respiratory JJ cord-007277-86lynlxn 68 17 tract tract NN cord-007277-86lynlxn 68 18 disease disease NN cord-007277-86lynlxn 68 19 in in IN cord-007277-86lynlxn 68 20 infants infant NNS cord-007277-86lynlxn 68 21 and and CC cord-007277-86lynlxn 68 22 young young JJ cord-007277-86lynlxn 68 23 children child NNS cord-007277-86lynlxn 68 24 Association Association NNP cord-007277-86lynlxn 68 25 between between IN cord-007277-86lynlxn 68 26 a a DT cord-007277-86lynlxn 68 27 novel novel JJ cord-007277-86lynlxn 68 28 human human JJ cord-007277-86lynlxn 68 29 coronavirus coronavirus NN cord-007277-86lynlxn 68 30 and and CC cord-007277-86lynlxn 68 31 Kawasaki Kawasaki NNP cord-007277-86lynlxn 68 32 disease disease NN cord-007277-86lynlxn 68 33 Identification identification NN cord-007277-86lynlxn 68 34 of of IN cord-007277-86lynlxn 68 35 a a DT cord-007277-86lynlxn 68 36 new new JJ cord-007277-86lynlxn 68 37 human human JJ cord-007277-86lynlxn 68 38 coronavirus coronavirus NN cord-007277-86lynlxn 68 39 A a DT cord-007277-86lynlxn 68 40 previously previously RB cord-007277-86lynlxn 68 41 undescribed undescribed JJ cord-007277-86lynlxn 68 42 coronavirus coronavirus NN cord-007277-86lynlxn 68 43 associated associate VBN cord-007277-86lynlxn 68 44 with with IN cord-007277-86lynlxn 68 45 respiratory respiratory JJ cord-007277-86lynlxn 68 46 disease disease NN cord-007277-86lynlxn 68 47 in in IN cord-007277-86lynlxn 68 48 humans human NNS cord-007277-86lynlxn 68 49 Recovery Recovery NNP cord-007277-86lynlxn 68 50 in in IN cord-007277-86lynlxn 68 51 tracheal tracheal JJ cord-007277-86lynlxn 68 52 organ organ NN cord-007277-86lynlxn 68 53 cultures culture NNS cord-007277-86lynlxn 68 54 of of IN cord-007277-86lynlxn 68 55 novel novel NN cord-007277-86lynlxn 68 56 viruses virus NNS cord-007277-86lynlxn 68 57 from from IN cord-007277-86lynlxn 68 58 patients patient NNS cord-007277-86lynlxn 68 59 with with IN cord-007277-86lynlxn 68 60 respiratory respiratory JJ cord-007277-86lynlxn 68 61 disease disease NN cord-007277-86lynlxn 68 62 Polymerase polymerase NN cord-007277-86lynlxn 68 63 activity activity NN cord-007277-86lynlxn 68 64 in in IN cord-007277-86lynlxn 68 65 lymphocyte lymphocyte NN cord-007277-86lynlxn 68 66 culture culture NN cord-007277-86lynlxn 68 67 supernatants supernatant NNS cord-007277-86lynlxn 68 68 from from IN cord-007277-86lynlxn 68 69 patients patient NNS cord-007277-86lynlxn 68 70 with with IN cord-007277-86lynlxn 68 71 Kawasaki Kawasaki NNP cord-007277-86lynlxn 68 72 disease disease NN cord-007277-86lynlxn 68 73 Active active JJ cord-007277-86lynlxn 68 74 or or CC cord-007277-86lynlxn 68 75 recent recent JJ cord-007277-86lynlxn 68 76 parvovirus parvovirus NN cord-007277-86lynlxn 68 77 B19 B19 NNP cord-007277-86lynlxn 68 78 infection infection NN cord-007277-86lynlxn 68 79 in in IN cord-007277-86lynlxn 68 80 children child NNS cord-007277-86lynlxn 68 81 with with IN cord-007277-86lynlxn 68 82 Kawasaki Kawasaki NNP cord-007277-86lynlxn 68 83 disease disease NN cord-007277-86lynlxn 68 84 Detection detection NN cord-007277-86lynlxn 68 85 of of IN cord-007277-86lynlxn 68 86 Epstein Epstein NNP cord-007277-86lynlxn 68 87 - - HYPH cord-007277-86lynlxn 68 88 Barr Barr NNP cord-007277-86lynlxn 68 89 virus virus NN cord-007277-86lynlxn 68 90 DNA dna NN cord-007277-86lynlxn 68 91 in in IN cord-007277-86lynlxn 68 92 cardiac cardiac JJ cord-007277-86lynlxn 68 93 and and CC cord-007277-86lynlxn 68 94 aortic aortic JJ cord-007277-86lynlxn 68 95 tissues tissue NNS cord-007277-86lynlxn 68 96 from from IN cord-007277-86lynlxn 68 97 chronic chronic JJ cord-007277-86lynlxn 68 98 , , , cord-007277-86lynlxn 68 99 active active JJ cord-007277-86lynlxn 68 100 Epstein Epstein NNP cord-007277-86lynlxn 68 101 - - HYPH cord-007277-86lynlxn 68 102 Barr Barr NNP cord-007277-86lynlxn 68 103 virus virus NN cord-007277-86lynlxn 68 104 infection infection NN cord-007277-86lynlxn 68 105 associated associate VBN cord-007277-86lynlxn 68 106 with with IN cord-007277-86lynlxn 68 107 Kawasaki Kawasaki NNP cord-007277-86lynlxn 68 108 disease disease NN cord-007277-86lynlxn 68 109 - - HYPH cord-007277-86lynlxn 68 110 like like JJ cord-007277-86lynlxn 68 111 coronary coronary JJ cord-007277-86lynlxn 68 112 artery artery NN cord-007277-86lynlxn 68 113 aneurysms aneurysm NNS cord-007277-86lynlxn 68 114 Demonstration demonstration NN cord-007277-86lynlxn 68 115 of of IN cord-007277-86lynlxn 68 116 Chlamydia Chlamydia NNP cord-007277-86lynlxn 68 117 pneumoniae pneumoniae NN cord-007277-86lynlxn 68 118 in in IN cord-007277-86lynlxn 68 119 cardiovascular cardiovascular JJ cord-007277-86lynlxn 68 120 tissues tissue NNS cord-007277-86lynlxn 68 121 from from IN cord-007277-86lynlxn 68 122 children child NNS cord-007277-86lynlxn 68 123 with with IN cord-007277-86lynlxn 68 124 Kawasaki Kawasaki NNP cord-007277-86lynlxn 68 125 disease disease NN cord-007277-86lynlxn 69 1 Toxic toxic JJ cord-007277-86lynlxn 69 2 shock shock NN cord-007277-86lynlxn 69 3 syndrome syndrome NN cord-007277-86lynlxn 69 4 toxin toxin NN cord-007277-86lynlxn 69 5 - - HYPH cord-007277-86lynlxn 69 6 secreting secrete VBG cord-007277-86lynlxn 69 7 Staphylococcus Staphylococcus NNP cord-007277-86lynlxn 69 8 aureus aureus NN cord-007277-86lynlxn 69 9 in in IN cord-007277-86lynlxn 69 10 Kawasaki Kawasaki NNP cord-007277-86lynlxn 69 11 syndrome syndrome NN cord-007277-86lynlxn 69 12 Kawasaki Kawasaki NNP cord-007277-86lynlxn 69 13 syndrome syndrome NN cord-007277-86lynlxn 69 14 : : : cord-007277-86lynlxn 69 15 description description NN cord-007277-86lynlxn 69 16 of of IN cord-007277-86lynlxn 69 17 two two CD cord-007277-86lynlxn 69 18 outbreaks outbreak NNS cord-007277-86lynlxn 69 19 in in IN cord-007277-86lynlxn 69 20 the the DT cord-007277-86lynlxn 69 21 United United NNP cord-007277-86lynlxn 69 22 States States NNP cord-007277-86lynlxn 69 23 Investigation Investigation NNP cord-007277-86lynlxn 69 24 of of IN cord-007277-86lynlxn 69 25 Kawasaki Kawasaki NNP cord-007277-86lynlxn 69 26 syndrome syndrome NN cord-007277-86lynlxn 69 27 risk risk NN cord-007277-86lynlxn 69 28 factors factor NNS cord-007277-86lynlxn 69 29 in in IN cord-007277-86lynlxn 69 30 Colorado Colorado NNP cord-007277-86lynlxn 69 31 Effect Effect NNP cord-007277-86lynlxn 69 32 of of IN cord-007277-86lynlxn 69 33 specific specific JJ cord-007277-86lynlxn 69 34 humoral humoral JJ cord-007277-86lynlxn 69 35 immunity immunity NN cord-007277-86lynlxn 69 36 and and CC cord-007277-86lynlxn 69 37 some some DT cord-007277-86lynlxn 69 38 non non JJ cord-007277-86lynlxn 69 39 - - JJ cord-007277-86lynlxn 69 40 specific specific JJ cord-007277-86lynlxn 69 41 factors factor NNS cord-007277-86lynlxn 69 42 on on IN cord-007277-86lynlxn 69 43 resistance resistance NN cord-007277-86lynlxn 69 44 of of IN cord-007277-86lynlxn 69 45 volunteers volunteer NNS cord-007277-86lynlxn 69 46 to to IN cord-007277-86lynlxn 69 47 respiratory respiratory JJ cord-007277-86lynlxn 69 48 coronavirus coronavirus NN cord-007277-86lynlxn 69 49 infection infection NN cord-007277-86lynlxn 69 50 Detection detection NN cord-007277-86lynlxn 69 51 of of IN cord-007277-86lynlxn 69 52 human human JJ cord-007277-86lynlxn 69 53 coronavirus coronavirus NN cord-007277-86lynlxn 69 54 229E 229e CD cord-007277-86lynlxn 69 55 in in IN cord-007277-86lynlxn 69 56 nasal nasal NN cord-007277-86lynlxn 69 57 washings washing NNS cord-007277-86lynlxn 69 58 using use VBG cord-007277-86lynlxn 69 59 RNA RNA NNP cord-007277-86lynlxn 70 1 : : : cord-007277-86lynlxn 70 2 RNA rna NN cord-007277-86lynlxn 70 3 hybridisation hybridisation NN cord-007277-86lynlxn 71 1 The the DT cord-007277-86lynlxn 71 2 time time NN cord-007277-86lynlxn 71 3 course course NN cord-007277-86lynlxn 71 4 of of IN cord-007277-86lynlxn 71 5 the the DT cord-007277-86lynlxn 71 6 immune immune JJ cord-007277-86lynlxn 71 7 response response NN cord-007277-86lynlxn 71 8 to to IN cord-007277-86lynlxn 71 9 experimental experimental JJ cord-007277-86lynlxn 71 10 coronavirus coronavirus NN cord-007277-86lynlxn 71 11 infection infection NN cord-007277-86lynlxn 71 12 of of IN cord-007277-86lynlxn 71 13 man man NN cord-007277-86lynlxn 71 14 IgA IgA NNP cord-007277-86lynlxn 71 15 plasma plasma NN cord-007277-86lynlxn 71 16 cell cell NN cord-007277-86lynlxn 71 17 infiltration infiltration NN cord-007277-86lynlxn 71 18 of of IN cord-007277-86lynlxn 71 19 proximal proximal JJ cord-007277-86lynlxn 71 20 respiratory respiratory JJ cord-007277-86lynlxn 71 21 tract tract NN cord-007277-86lynlxn 71 22 , , , cord-007277-86lynlxn 71 23 pancreas pancrea NNS cord-007277-86lynlxn 71 24 , , , cord-007277-86lynlxn 71 25 kidney kidney NN cord-007277-86lynlxn 71 26 , , , cord-007277-86lynlxn 71 27 and and CC cord-007277-86lynlxn 71 28 coronary coronary JJ cord-007277-86lynlxn 71 29 artery artery NN cord-007277-86lynlxn 71 30 in in IN cord-007277-86lynlxn 71 31 acute acute JJ cord-007277-86lynlxn 71 32 Kawasaki Kawasaki NNP cord-007277-86lynlxn 71 33 disease disease NN cord-007277-86lynlxn 71 34 Oligoclonal Oligoclonal NNP cord-007277-86lynlxn 71 35 IgA IgA NNP cord-007277-86lynlxn 71 36 response response NN cord-007277-86lynlxn 71 37 in in IN cord-007277-86lynlxn 71 38 the the DT cord-007277-86lynlxn 71 39 vascular vascular JJ cord-007277-86lynlxn 71 40 wall wall NN cord-007277-86lynlxn 71 41 in in IN cord-007277-86lynlxn 71 42 acute acute JJ cord-007277-86lynlxn 71 43 Kawasaki Kawasaki NNP cord-007277-86lynlxn 71 44 disease disease NN cord-007277-86lynlxn 71 45 Detection detection NN cord-007277-86lynlxn 71 46 of of IN cord-007277-86lynlxn 71 47 antigen antigen NN cord-007277-86lynlxn 71 48 in in IN cord-007277-86lynlxn 71 49 bronchial bronchial JJ cord-007277-86lynlxn 71 50 epithelium epithelium NN cord-007277-86lynlxn 71 51 and and CC cord-007277-86lynlxn 71 52 macrophages macrophage NNS cord-007277-86lynlxn 71 53 in in IN cord-007277-86lynlxn 71 54 acute acute JJ cord-007277-86lynlxn 71 55 Kawasaki Kawasaki NNP cord-007277-86lynlxn 71 56 disease disease NN cord-007277-86lynlxn 71 57 by by IN cord-007277-86lynlxn 71 58 use use NN cord-007277-86lynlxn 71 59 of of IN cord-007277-86lynlxn 71 60 synthetic synthetic JJ cord-007277-86lynlxn 71 61 antibody antibody NN cord-007277-86lynlxn 71 62 Kawasaki Kawasaki NNP cord-007277-86lynlxn 71 63 syndrome syndrome NN cord-007277-86lynlxn 71 64 Cutting cutting NN cord-007277-86lynlxn 71 65 edge edge NN cord-007277-86lynlxn 71 66 : : : cord-007277-86lynlxn 71 67 CD8 CD8 NNP cord-007277-86lynlxn 71 68 T T NNP cord-007277-86lynlxn 71 69 cell cell NN cord-007277-86lynlxn 71 70 - - HYPH cord-007277-86lynlxn 71 71 mediated mediate VBN cord-007277-86lynlxn 71 72 demyelination demyelination NN cord-007277-86lynlxn 71 73 is be VBZ cord-007277-86lynlxn 71 74 IFN IFN NNP cord-007277-86lynlxn 71 75 - - HYPH cord-007277-86lynlxn 71 76 gamma gamma NN cord-007277-86lynlxn 71 77 dependent dependent NN cord-007277-86lynlxn 71 78 in in IN cord-007277-86lynlxn 71 79 mice mouse NNS cord-007277-86lynlxn 71 80 infected infect VBN cord-007277-86lynlxn 71 81 with with IN cord-007277-86lynlxn 71 82 a a DT cord-007277-86lynlxn 71 83 neurotropic neurotropic NNP cord-007277-86lynlxn 71 84 coronavirus coronavirus NN cord-007277-86lynlxn 71 85 Natural natural JJ cord-007277-86lynlxn 71 86 history history NN cord-007277-86lynlxn 71 87 of of IN cord-007277-86lynlxn 71 88 a a DT cord-007277-86lynlxn 71 89 recurrent recurrent JJ cord-007277-86lynlxn 71 90 feline feline JJ cord-007277-86lynlxn 71 91 coronavirus coronavirus NN cord-007277-86lynlxn 71 92 infection infection NN cord-007277-86lynlxn 71 93 and and CC cord-007277-86lynlxn 71 94 the the DT cord-007277-86lynlxn 71 95 role role NN cord-007277-86lynlxn 71 96 of of IN cord-007277-86lynlxn 71 97 cellular cellular JJ cord-007277-86lynlxn 71 98 immunity immunity NN cord-007277-86lynlxn 71 99 in in IN cord-007277-86lynlxn 71 100 survival survival NN cord-007277-86lynlxn 71 101 and and CC cord-007277-86lynlxn 71 102 disease disease NN