id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-353495-c3s5n5vo	Yao, Yanfeng	An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus	2014-01-15		.txt	text/plain	3427	186	51	In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus–Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection. The development of animal models for MERS-CoV infection of humans is of utmost importance to study the pathogenesis of this virus and to test the efficacy of potential therapeutic or prophylactic intervention strategies. Therefore, in the present study, we explored the suitability of the rhesus monkey as an animal model for MERS-CoV isolate human coronavirus-Erasmus Medical Center (hCoV-EMC) infection or disease. Rhesus macaques can be infected by MERS-CoV in the laboratory, but we recognize that it is necessary to search for more suitable animal model that will have similar disease presentations as that observed among those laboratoryconfirmed human cases.	./cache/cord-353495-c3s5n5vo.txt	./txt/cord-353495-c3s5n5vo.txt