id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-351776-otx5qwyu	Ibáñez-Samaniego, Luis	Elevation of Liver Fibrosis Index FIB-4 Is Associated With Poor Clinical Outcomes in Patients With COVID-19	2020-06-21		.txt	text/plain	3896	189	44	In this study, we evaluated the association between FIB-4, a liver fibrosis index, and the risk of progression to critical illness in middle-aged patients with COVID-19. To overcome this problem, we analyzed our data in different ways: (1) we retrieved available information on blood test done within 6 months before COVID-19 diagnosis in a relatively small number of patients (15% of the total series): at the time of COVID-19 diagnosis, AST and ALT increased significantly while platelets remained stable as compared with previous values; however, there were no significant changes in FIB-4 categories; (2) we evaluated specifically the prognostic value of isolated baseline AST: in contrast to previous reports, AST was not an independent predictor either at univariate level or when adjusted by other clinical and laboratory covariates; and (3) finally, we evaluated specifically the association between the elevation of AST (ie, AST above the upper limit of normality) and the need for MV, which identified that AST elevation was an independent risk factor.	./cache/cord-351776-otx5qwyu.txt	./txt/cord-351776-otx5qwyu.txt