id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-345101-h0i5o0do	Koo, Bon-Sang	Transient lymphopenia and interstitial pneumonia with endotheliitis in SARS-CoV-2-infected macaques	2020-08-03		.txt	text/plain	1808	123	55	Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The absence of a reliable preclinical animal model that recapitulates patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection poses a major limitation to the development of improved diagnostics and therapeutics. Studies reported that SARS-CoV-2 developed no severe clinical signs, but pulmonary pneumonia in 50% of cynomolgus macaques, recapitulating mild symptoms in humans [6] . The viral RNA was highest in the upper respiratory swab samples and lung tissues at the earliest phase of infection, and the viral antigen was present in the lungs ( Figure 1C and D) , suggesting the predominant site of the virus. Using a high viral titre administered through combined routes, virus assays, and histopathological changes suggests that both cynomolgus and rhesus macaques are permissive to infection of SARS-CoV-2 and recapitulate COVID-19-like disease in human.	./cache/cord-345101-h0i5o0do.txt	./txt/cord-345101-h0i5o0do.txt