id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-324001-m7ys95z7	Kobinger, Gary P.	Assessment of the Efficacy of Commercially Available and Candidate Vaccines against a Pandemic H1N1 2009 Virus	2010-04-01		.txt	text/plain	3578	153	39	Groups of five 16-to 20-weekold ferrets without antibodies against circulating influenza strains were immunized with one of the 2008 seasonal inactivated split vaccines (Fluviral; GlaxoSmithKline) or the cold-adapted live attenuated vaccine (FluMist; MedImmune), a swine influenza vaccine (FluSure; Pfizer), or a matched laboratory-produced inactivated vaccine (pH1N1inact). HAI antibody titers against the pandemic H1N1 2009 MX10 isolate were detected at day 7 in ferrets receiving the laboratory-produced matched vaccine pH1N1inact or the swine influenza vaccine FluSure, reaching titers 140 on day 7 or 10, respectively. Toward this end, we compared the antibody and cellular responses elicited by 2 seasonal vaccines (Fluviral and FluMist), the commercial swine vaccine FluSure, and a laboratory-produced matched inactivated whole-virus preparation. A curious observation is the more severe cases of disease and the higher mortality rate noted for animals vaccinated with FluMist, which correlated with slightly more infectious virus in the nasal washes of this group at day 3.	./cache/cord-324001-m7ys95z7.txt	./txt/cord-324001-m7ys95z7.txt