id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-317232-qk72i0gv	Gierer, Stefanie	Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity	2015-03-15		.txt	text/plain	4936	216	46	title: Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity However, activation of viral glycoproteins, including activation of the S protein of certain strains of the coronavirus infectious bronchitis virus (IBV) [18] , may also proceed in the constitutive secretory pathway of infected cells and is often accomplished by furin and other proprotein convertases [19] [20] [21] [22] . Treatment of MERS-CoV-infected cells with a proprotein convertase inhibitor (PCI) abrogated S protein cleavage but did not alter viral infectivity, indicating that S protein processing in infected cells is dispensable for MERS-S activation. In sum, our results identify MERS-S as a substrate of proprotein convertases but indicate that the activity of these enzymes is dispensable for MERS-CoV spread in target cell lines and potentially also in the infected human host.	./cache/cord-317232-qk72i0gv.txt	./txt/cord-317232-qk72i0gv.txt