id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007237-8y7218oj	Manning, Ashleigh	Comparison of Tissue Distribution, Persistence, and Molecular Epidemiology of Parvovirus B19 and Novel Human Parvoviruses PARV4 and Human Bocavirus	2007-05-01		.txt	text/plain	4514	199	45	At autopsy, bone marrow, lymphoid tissue, and brain tissue from human immunodeficiency virus (HIV)—infected individuals with acquired immunodeficiency syndrome (AIDS) and those without AIDS and from HIV-uninfected individuals were screened for parvovirus B19, PARV4, and HBoV DNA by means of quantitative polymerase chain reaction analyses. In the current study, we examined a series of samples of different tissues, collected at autopsy, for the presence of HBoV and PARV4 DNA sequences and compared the frequencies of detection, viral loads, and genetic variability with those for B19. Samples from HIV-infected individuals who did not have AIDS (hereafter referred to as "pre-AIDS study subjects") and those with terminal AIDS at time of death were compared with corresponding samples from HIV-uninfected individuals, to investigate the relationship between viral load and immunosuppression and, thus, the role of the immune system in controlling virus replication. Among the HIV-infected study subjects, a similar difference was found in PARV4 viral loads in bone marrow versus lymphoid tissue (median values of 220 and 46 DNA copies/10 6 cells, respectively; ) (figure 1B).	./cache/cord-007237-8y7218oj.txt	./txt/cord-007237-8y7218oj.txt