id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000842-kff3gig0	Nayak, Jennifer L.	CD4(+) T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine	2013-01-15		.txt	text/plain	4900	221	42	Knowledge of the relationship between CD4 + T cells and the development of a neutralizing antibody response following administration of TIV is even more limited, with the few studies addressing this question failing to find a correlation between these parameters [12, 20] , except when an adjuvanted influenza A virus subtype H5N1 vaccine was used [29] . In this study, we used an experimental approach designed to maximally detect antigen-specific CD4 + T cells by using cytokine enzyme-linked immunosorbent spot (ELISPOT) assays with pools of overlapping synthetic peptides as recall antigens to quantify responses to conserved and novel epitopes following vaccination of adults with monovalent inactivated A (H1N1)pdm09 vaccine. We conclude from this that expansion of CD4 + T cells rather than the baseline number of influenza virus-reactive cells correlates with and predicts the development of a neutralizing antibody response following A (H1N1)pdm09 vaccination, a result that is consistent with the idea that CD4 + T-cell help may limit the antibody response to pandemic influenza vaccines.	./cache/cord-000842-kff3gig0.txt	./txt/cord-000842-kff3gig0.txt