id author title date pages extension mime words sentences flesch summary cache txt cord-309476-hel3h25h Brown, Julianne R. Encephalitis diagnosis using metagenomics: application of next generation sequencing for undiagnosed cases 2018-01-02 .txt text/plain 5816 290 38 This included two cases of human parvovirus 4 (PARV4), 28 first described in 2005 when it was associated with a viraemic patient in whom an acute viral infection was suspected 49 ; one case of human coronavirus OC-43, 43 typically a human respiratory pathogen never previously described in a human case of encephalitis but known to cause encephalitis in mice 50 ; one case of human astrovirus MLB1, 46 of mumps vaccine virus in a child who was vaccinated prior to a primary immunodeficiency diagnosis. As with other molecular tests, including PCR which has become the gold standard of virological diagnostics, results from metagenomics applied to cases of encephalitis should be interpreted in the context of other clinical and laboratory findings, particularly when a novel or unexpected organism is detected. ./cache/cord-309476-hel3h25h.txt ./txt/cord-309476-hel3h25h.txt