id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288814-1zayb21f	Lu, Qing-Bin	Comorbidities for fatal outcome among the COVID-19 patients: a hospital-based case-control study	2020-07-27		.txt	text/plain	1382	72	48	Here by performing a retrospective multi-center study, we try to evaluate the adjusted effect of the common preexisting comorbidities on COVID-19 related death, based on which, the therapy effect of three widely used anti-hypertension drugs were assessed. By multivariate logistic regression model adjusting age, sex, and delay from symptom onset to hospital admission, six comorbidities showed significant association with the disease outcome, with malignancy exhibiting the highest risk of death, followed by CKD, CVD, hypertension, CHD, and DM ( Figure 1A and Table S2 ). DM was found to be a strong risk factor for adverse outcome, with its risky effect also observed in those aged 60~70 years, which was reported for the two earlier CoV infections, severe acute respiratory syndrome (7) and the Middle East respiratory syndrome (8) . We provided evidence 5 that CCB drugs offered beneficial effect of reducing risk for fatal outcome in hypertension-COVID-19 patients, mostly mediated through enhancing the recovery of abnormal parameters and reducing host inflammatory response that had been proven to aggravate the disease severity.	./cache/cord-288814-1zayb21f.txt	./txt/cord-288814-1zayb21f.txt