id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284862-nhihxog0	Kroemer, Marie	COVID-19 patients display distinct SARS-CoV-2 specific T-cell responses according to disease severity	2020-08-25		.txt	text/plain	1043	63	49	Although the existence of SARS-CoV-2 specific T-cells has been described 2,3 , the frequency and the intensity of SARS-CoV-2 specific T-cell responses among mild illness and severe pneumonia convalescent COVID-19 patients remains to be investigated. In this prospective study, 60 patients who had COVID-19 were enrolled in a two cohorts study that were entitled mild illness (n=30) and severe pneumonia (n=30) at least 21 days after the first symptoms of ; Table 1 for CoV-N) might be explained by the sequence homology between structural proteins from various coronavirus suggesting the existence of cross reactive memory T-cells 5 . We observed that all patients with severe pneumonia had a positive serology index and most of them had at least one specific cellular response for SARS-CoV-2 proteins (28 out of 30). Specific T-cell responses for S, M and N proteins were simultaneously shown for 70.0% of severe pneumonia patients while only for 37.9% of mild illness patients (P=0.0191) (Fig. 1E) .	./cache/cord-284862-nhihxog0.txt	./txt/cord-284862-nhihxog0.txt