id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282053-ftjx29lw	Luis García de GuadianaRomualdo	Circulating levels of GDF-15 and calprotectin for prediction of in-hospital mortality in COVID-19 patients: a case series	2020-08-12		.txt	text/plain	840	50	48	We read the recent articles by Li and colleagues and Lin and colleagues about the role of two inflammatory biomarkers, serum amyloid A 1 and ferritin 2 , in the evaluation of severity in coronavirus disease 2019 (COVID-19) patients. Higher blood levels of inflammatory biomarkers in blood, such as C-reactive protein (CRP), ferritin and D-dimer, have been reported as predictors of a poor outcome in COVID-19 patients 5 . The role of biomarkers associated to inflammation other than those above mentioned, such as calprotectin or growth differentiation factor 15 (GDF-15), is less known. Recently, an experimental study showed a novel function of GDF-15 in the promotion of lung human rhinovirus and virus-associated inflammation, contributing to the severity of respiratory viral infection 10 . We have shown that circulating levels of two emerging inflammatory biomarkers, calprotectin and GDF-15, are significantly higher in COVID-19 patients who died, suggesting a potential role in the evaluation of prognosis in these patients.	./cache/cord-282053-ftjx29lw.txt	./txt/cord-282053-ftjx29lw.txt