id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336535-r3a57m57	Kohmer, Niko	Brief clinical evaluation of six high-throughput SARS-CoV-2 IgG antibody assays	2020-06-01		.txt	text/plain	1479	91	52	So far, there is limited data on how recently commercially available, high-throughput immunoassays, using different recombinant SARS-CoV-2 antigens, perform with clinical samples. Five follow-up samples of three individuals were only detected in either an S and/or N protein-based assay, indicating an individual different immune response to SARS-CoV-2 and the influence of the used assay in the detection of IgG antibodies. This study aims to provide a quick overview on some of these assays (two commercially available ELISA assays, four automated immunoassays and a plaque reduction neutralization test (PRNT)) focusing on the detection and neutralization capacity of IgG antibodies in follow up serum or plasma samples of individuals with PCR-diagnosed infections with SARS-CoV-2. The commercially available assays examined in our study, generated consistent results regarding the detection of SARS-CoV-2-IgG antibodies. Interestingly, in samples of three individuals with mild clinical course of COVID-19, examined in our study (1, 2, 3 in The automated immunoassays demonstrated a higher overall sensitivity than the ELISA based assays.	./cache/cord-336535-r3a57m57.txt	./txt/cord-336535-r3a57m57.txt