id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291553-j9nn5g70	Fridholm, Helena	Human pegivirus detected in a patient with severe encephalitis using a metagenomic pan-virus array	2016-01-29		.txt	text/plain	2016	120	50	title: Human pegivirus detected in a patient with severe encephalitis using a metagenomic pan-virus array We have used a metagenomic microarray to detect genomic RNA from human pegivirus in serum and cerebrospinal fluid from a patient suffering from severe encephalitis. We report a case of severe encephalitis where the only microbe detected in the CNS was human pegivirus (HPgV), hitherto only known to cause asymptomatic infections in humans. In both cases it is uncertain if HPgV is pathogenic but it is noteworthy to detect a virus at a high viral load in the CNS. More recently, both positive and negative RNA-strands of HPgV was detected in post mortem brain tissue from a multiple sclerosis (MS) patient, implying that the virus was replicating in the brain tissue [1] . All CSF samples where negative for HPgV but one encephalitis patient was positive in serum (Ct 27.2).	./cache/cord-291553-j9nn5g70.txt	./txt/cord-291553-j9nn5g70.txt