id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-027649-6xn9swsq	Addetia, Amin	Identification of multiple large deletions in ORF7a resulting in in-frame gene fusions in clinical SARS-CoV-2 isolates	2020-06-23		.txt	text/plain	449	47	52	title: Identification of multiple large deletions in ORF7a resulting in in-frame gene fusions in clinical SARS-CoV-2 isolates Sequence reads were trimmed using Trimommatic v0.38 (5) , aligned to the SARS-CoV-2 reference genome (NC_045512.2) using BBMap (https://sourceforge.net/projects/bbmap/), trimmed of synthetic PCR primers using Primerclip (https://github.com/swiftbiosciences/primerclip) if appropriate, and visualized in Geneious v11.1.4 (6) . Interestingly, ORF6 of SARS-CoV-2 interacts with the mRNA export proteins NUP98 and RAE1, and may inhibit cellular translation (10) . We predict global sequencing projects may yield additional clinical SARS-CoV-2 isolates with deletions in ORF6 or ORF7a, but not both. Metagenomic analysis reveals clinical SARS-CoV-2 infection and bacterial or viral superinfection and colonization An 81 nucleotide deletion in SARS-CoV Structure and intracellular targeting of the SARS-coronavirus Orf7a accessory protein A SARS-CoV-2 protein interaction map reveals targets for drug repurposing A 227-nucleotide deletion beginning at nt 27,524 was identified in b) WA-UW-5812 and resulted in the fusion of ORF7a and ORF7b.	./cache/cord-027649-6xn9swsq.txt	./txt/cord-027649-6xn9swsq.txt