id	sid	tid	token	lemma	pos
cord-289034-yl3emjef	1	1	key	key	NNP
cord-289034-yl3emjef	1	2	:	:	:
cord-289034-yl3emjef	1	3	cord-289034-yl3emjef	cord-289034-yl3emjef	.
cord-289034-yl3emjef	2	1	authors	author	NNS
cord-289034-yl3emjef	2	2	:	:	:
cord-289034-yl3emjef	3	1	Moro	moro	UH
cord-289034-yl3emjef	3	2	,	,	,
cord-289034-yl3emjef	3	3	Loredana	Loredana	NNP
cord-289034-yl3emjef	3	4	title	title	NN
cord-289034-yl3emjef	3	5	:	:	:
cord-289034-yl3emjef	3	6	Mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	3	7	at	at	IN
cord-289034-yl3emjef	3	8	the	the	DT
cord-289034-yl3emjef	3	9	Crossroads	Crossroads	NNP
cord-289034-yl3emjef	3	10	of	of	IN
cord-289034-yl3emjef	3	11	Physiology	Physiology	NNP
cord-289034-yl3emjef	3	12	and	and	CC
cord-289034-yl3emjef	3	13	Pathology	Pathology	NNP
cord-289034-yl3emjef	3	14	date	date	NN
cord-289034-yl3emjef	3	15	:	:	:
cord-289034-yl3emjef	3	16	2020	2020	CD
cord-289034-yl3emjef	3	17	-	-	HYPH
cord-289034-yl3emjef	3	18	06	06	CD
cord-289034-yl3emjef	3	19	-	-	HYPH
cord-289034-yl3emjef	3	20	24	24	CD
cord-289034-yl3emjef	3	21	journal	journal	NN
cord-289034-yl3emjef	3	22	:	:	:
cord-289034-yl3emjef	3	23	J	J	NNP
cord-289034-yl3emjef	3	24	Clin	Clin	NNP
cord-289034-yl3emjef	3	25	Med	Med	NNP
cord-289034-yl3emjef	3	26	DOI	doi	NN
cord-289034-yl3emjef	3	27	:	:	:
cord-289034-yl3emjef	4	1	10.3390/	10.3390/	CD
cord-289034-yl3emjef	5	1	jcm9061971	jcm9061971	NNP
cord-289034-yl3emjef	5	2	sha	sha	NNP
cord-289034-yl3emjef	5	3	:	:	:
cord-289034-yl3emjef	5	4	cafab076459af759669d702234bd6b84fd8ce572	cafab076459af759669d702234bd6b84fd8ce572	VB
cord-289034-yl3emjef	5	5	doc_id	doc_id	CD
cord-289034-yl3emjef	5	6	:	:	:
cord-289034-yl3emjef	6	1	289034	289034	CD
cord-289034-yl3emjef	6	2	cord_uid	cord_uid	NNS
cord-289034-yl3emjef	6	3	:	:	:
cord-289034-yl3emjef	6	4	yl3emjef	yl3emjef	.
cord-289034-yl3emjef	7	1	Mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	7	2	play	play	VBP
cord-289034-yl3emjef	7	3	a	a	DT
cord-289034-yl3emjef	7	4	crucial	crucial	JJ
cord-289034-yl3emjef	7	5	role	role	NN
cord-289034-yl3emjef	7	6	in	in	IN
cord-289034-yl3emjef	7	7	cell	cell	NN
cord-289034-yl3emjef	7	8	life	life	NN
cord-289034-yl3emjef	7	9	and	and	CC
cord-289034-yl3emjef	7	10	death	death	NN
cord-289034-yl3emjef	7	11	by	by	IN
cord-289034-yl3emjef	7	12	regulating	regulate	VBG
cord-289034-yl3emjef	7	13	bioenergetic	bioenergetic	JJ
cord-289034-yl3emjef	7	14	and	and	CC
cord-289034-yl3emjef	7	15	biosynthetic	biosynthetic	JJ
cord-289034-yl3emjef	7	16	pathways	pathway	NNS
cord-289034-yl3emjef	7	17	.	.	.
cord-289034-yl3emjef	8	1	They	-PRON-	PRP
cord-289034-yl3emjef	8	2	are	be	VBP
cord-289034-yl3emjef	8	3	able	able	JJ
cord-289034-yl3emjef	8	4	to	to	TO
cord-289034-yl3emjef	8	5	adapt	adapt	VB
cord-289034-yl3emjef	8	6	rapidly	rapidly	RB
cord-289034-yl3emjef	8	7	to	to	IN
cord-289034-yl3emjef	8	8	different	different	JJ
cord-289034-yl3emjef	8	9	microenvironmental	microenvironmental	JJ
cord-289034-yl3emjef	8	10	stressors	stressor	NNS
cord-289034-yl3emjef	8	11	by	by	IN
cord-289034-yl3emjef	8	12	accommodating	accommodate	VBG
cord-289034-yl3emjef	8	13	the	the	DT
cord-289034-yl3emjef	8	14	metabolic	metabolic	JJ
cord-289034-yl3emjef	8	15	and	and	CC
cord-289034-yl3emjef	8	16	biosynthetic	biosynthetic	JJ
cord-289034-yl3emjef	8	17	needs	need	NNS
cord-289034-yl3emjef	8	18	of	of	IN
cord-289034-yl3emjef	8	19	the	the	DT
cord-289034-yl3emjef	8	20	cell	cell	NN
cord-289034-yl3emjef	8	21	.	.	.
cord-289034-yl3emjef	9	1	Mounting	mount	VBG
cord-289034-yl3emjef	9	2	evidence	evidence	NN
cord-289034-yl3emjef	9	3	places	place	NNS
cord-289034-yl3emjef	9	4	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	9	5	dysfunction	dysfunction	NN
cord-289034-yl3emjef	9	6	at	at	IN
cord-289034-yl3emjef	9	7	the	the	DT
cord-289034-yl3emjef	9	8	core	core	NN
cord-289034-yl3emjef	9	9	of	of	IN
cord-289034-yl3emjef	9	10	several	several	JJ
cord-289034-yl3emjef	9	11	diseases	disease	NNS
cord-289034-yl3emjef	9	12	,	,	,
cord-289034-yl3emjef	9	13	notably	notably	RB
cord-289034-yl3emjef	9	14	in	in	IN
cord-289034-yl3emjef	9	15	the	the	DT
cord-289034-yl3emjef	9	16	context	context	NN
cord-289034-yl3emjef	9	17	of	of	IN
cord-289034-yl3emjef	9	18	pathologies	pathology	NNS
cord-289034-yl3emjef	9	19	of	of	IN
cord-289034-yl3emjef	9	20	the	the	DT
cord-289034-yl3emjef	9	21	cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	9	22	and	and	CC
cord-289034-yl3emjef	9	23	central	central	JJ
cord-289034-yl3emjef	9	24	nervous	nervous	JJ
cord-289034-yl3emjef	9	25	system	system	NN
cord-289034-yl3emjef	9	26	.	.	.
cord-289034-yl3emjef	10	1	In	in	IN
cord-289034-yl3emjef	10	2	addition	addition	NN
cord-289034-yl3emjef	10	3	,	,	,
cord-289034-yl3emjef	10	4	mutations	mutation	NNS
cord-289034-yl3emjef	10	5	in	in	IN
cord-289034-yl3emjef	10	6	some	some	DT
cord-289034-yl3emjef	10	7	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	10	8	proteins	protein	NNS
cord-289034-yl3emjef	10	9	are	be	VBP
cord-289034-yl3emjef	10	10	bona	bona	JJ
cord-289034-yl3emjef	10	11	fide	fide	JJ
cord-289034-yl3emjef	10	12	cancer	cancer	NN
cord-289034-yl3emjef	10	13	drivers	driver	NNS
cord-289034-yl3emjef	10	14	.	.	.
cord-289034-yl3emjef	11	1	Better	well	JJR
cord-289034-yl3emjef	11	2	understanding	understanding	NN
cord-289034-yl3emjef	11	3	of	of	IN
cord-289034-yl3emjef	11	4	the	the	DT
cord-289034-yl3emjef	11	5	functions	function	NNS
cord-289034-yl3emjef	11	6	of	of	IN
cord-289034-yl3emjef	11	7	these	these	DT
cord-289034-yl3emjef	11	8	multifaceted	multifaceted	JJ
cord-289034-yl3emjef	11	9	organelles	organelle	NNS
cord-289034-yl3emjef	11	10	and	and	CC
cord-289034-yl3emjef	11	11	their	-PRON-	PRP$
cord-289034-yl3emjef	11	12	components	component	NNS
cord-289034-yl3emjef	11	13	may	may	MD
cord-289034-yl3emjef	11	14	finetune	finetune	VB
cord-289034-yl3emjef	11	15	our	-PRON-	PRP$
cord-289034-yl3emjef	11	16	knowledge	knowledge	NN
cord-289034-yl3emjef	11	17	on	on	IN
cord-289034-yl3emjef	11	18	the	the	DT
cord-289034-yl3emjef	11	19	molecular	molecular	JJ
cord-289034-yl3emjef	11	20	bases	basis	NNS
cord-289034-yl3emjef	11	21	of	of	IN
cord-289034-yl3emjef	11	22	certain	certain	JJ
cord-289034-yl3emjef	11	23	diseases	disease	NNS
cord-289034-yl3emjef	11	24	and	and	CC
cord-289034-yl3emjef	11	25	suggest	suggest	VBP
cord-289034-yl3emjef	11	26	new	new	JJ
cord-289034-yl3emjef	11	27	therapeutic	therapeutic	JJ
cord-289034-yl3emjef	11	28	avenues	avenue	NNS
cord-289034-yl3emjef	11	29	.	.	.
cord-289034-yl3emjef	12	1	Mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	12	2	are	be	VBP
cord-289034-yl3emjef	12	3	semi	semi	JJ
cord-289034-yl3emjef	12	4	-	-	JJ
cord-289034-yl3emjef	12	5	autonomous	autonomous	JJ
cord-289034-yl3emjef	12	6	organelles	organelle	NNS
cord-289034-yl3emjef	12	7	with	with	IN
cord-289034-yl3emjef	12	8	a	a	DT
cord-289034-yl3emjef	12	9	double	double	JJ
cord-289034-yl3emjef	12	10	membrane	membrane	NN
cord-289034-yl3emjef	12	11	system	system	NN
cord-289034-yl3emjef	12	12	,	,	,
cord-289034-yl3emjef	12	13	namely	namely	RB
cord-289034-yl3emjef	12	14	the	the	DT
cord-289034-yl3emjef	12	15	inner	inner	NN
cord-289034-yl3emjef	12	16	and	and	CC
cord-289034-yl3emjef	12	17	the	the	DT
cord-289034-yl3emjef	12	18	outer	outer	JJ
cord-289034-yl3emjef	12	19	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	12	20	membrane	membrane	NN
cord-289034-yl3emjef	12	21	that	that	WDT
cord-289034-yl3emjef	12	22	delimit	delimit	VBP
cord-289034-yl3emjef	12	23	the	the	DT
cord-289034-yl3emjef	12	24	intermembrane	intermembrane	NN
cord-289034-yl3emjef	12	25	space	space	NN
cord-289034-yl3emjef	12	26	.	.	.
cord-289034-yl3emjef	13	1	The	the	DT
cord-289034-yl3emjef	13	2	inner	inner	JJ
cord-289034-yl3emjef	13	3	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	13	4	membrane	membrane	NN
cord-289034-yl3emjef	13	5	demarcates	demarcate	VBZ
cord-289034-yl3emjef	13	6	the	the	DT
cord-289034-yl3emjef	13	7	matrix	matrix	NN
cord-289034-yl3emjef	13	8	,	,	,
cord-289034-yl3emjef	13	9	a	a	DT
cord-289034-yl3emjef	13	10	viscous	viscous	JJ
cord-289034-yl3emjef	13	11	microenvironment	microenvironment	NN
cord-289034-yl3emjef	13	12	that	that	WDT
cord-289034-yl3emjef	13	13	contains	contain	VBZ
cord-289034-yl3emjef	13	14	several	several	JJ
cord-289034-yl3emjef	13	15	enzymes	enzyme	NNS
cord-289034-yl3emjef	13	16	catalyzing	catalyze	VBG
cord-289034-yl3emjef	13	17	a	a	DT
cord-289034-yl3emjef	13	18	plethora	plethora	NN
cord-289034-yl3emjef	13	19	of	of	IN
cord-289034-yl3emjef	13	20	anabolic	anabolic	JJ
cord-289034-yl3emjef	13	21	and	and	CC
cord-289034-yl3emjef	13	22	catabolic	catabolic	JJ
cord-289034-yl3emjef	13	23	reactions	reaction	NNS
cord-289034-yl3emjef	13	24	.	.	.
cord-289034-yl3emjef	14	1	Mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	14	2	contain	contain	VBP
cord-289034-yl3emjef	14	3	their	-PRON-	PRP$
cord-289034-yl3emjef	14	4	own	own	JJ
cord-289034-yl3emjef	14	5	genome	genome	NN
cord-289034-yl3emjef	14	6	,	,	,
cord-289034-yl3emjef	14	7	the	the	DT
cord-289034-yl3emjef	14	8	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	14	9	DNA	dna	NN
cord-289034-yl3emjef	14	10	(	(	-LRB-
cord-289034-yl3emjef	14	11	mtDNA	mtDNA	NNP
cord-289034-yl3emjef	14	12	)	)	-RRB-
cord-289034-yl3emjef	14	13	,	,	,
cord-289034-yl3emjef	14	14	a	a	DT
cord-289034-yl3emjef	14	15	circular	circular	JJ
cord-289034-yl3emjef	14	16	double	double	RB
cord-289034-yl3emjef	14	17	-	-	HYPH
cord-289034-yl3emjef	14	18	stranded	strand	VBN
cord-289034-yl3emjef	14	19	DNA	dna	NN
cord-289034-yl3emjef	14	20	molecule	molecule	NN
cord-289034-yl3emjef	14	21	of	of	IN
cord-289034-yl3emjef	14	22	16,569	16,569	CD
cord-289034-yl3emjef	14	23	bp	bp	NNS
cord-289034-yl3emjef	14	24	in	in	IN
cord-289034-yl3emjef	14	25	humans	human	NNS
cord-289034-yl3emjef	14	26	,	,	,
cord-289034-yl3emjef	14	27	which	which	WDT
cord-289034-yl3emjef	14	28	encodes	encode	VBZ
cord-289034-yl3emjef	14	29	only	only	RB
cord-289034-yl3emjef	14	30	13	13	CD
cord-289034-yl3emjef	14	31	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	14	32	proteins	protein	NNS
cord-289034-yl3emjef	14	33	belonging	belong	VBG
cord-289034-yl3emjef	14	34	to	to	IN
cord-289034-yl3emjef	14	35	the	the	DT
cord-289034-yl3emjef	14	36	electron	electron	NN
cord-289034-yl3emjef	14	37	transport	transport	NN
cord-289034-yl3emjef	14	38	chain	chain	NN
cord-289034-yl3emjef	14	39	(	(	-LRB-
cord-289034-yl3emjef	14	40	ETC	etc	NN
cord-289034-yl3emjef	14	41	)	)	-RRB-
cord-289034-yl3emjef	14	42	,	,	,
cord-289034-yl3emjef	14	43	22	22	CD
cord-289034-yl3emjef	14	44	transfer	transfer	NN
cord-289034-yl3emjef	14	45	RNAs	rna	NNS
cord-289034-yl3emjef	14	46	and	and	CC
cord-289034-yl3emjef	14	47	2	2	CD
cord-289034-yl3emjef	14	48	ribosomal	ribosomal	JJ
cord-289034-yl3emjef	14	49	RNAs	rna	NNS
cord-289034-yl3emjef	14	50	needed	need	VBD
cord-289034-yl3emjef	14	51	to	to	TO
cord-289034-yl3emjef	14	52	carry	carry	VB
cord-289034-yl3emjef	14	53	out	out	RP
cord-289034-yl3emjef	14	54	the	the	DT
cord-289034-yl3emjef	14	55	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	14	56	protein	protein	NN
cord-289034-yl3emjef	14	57	synthesis	synthesis	NN
cord-289034-yl3emjef	14	58	.	.	.
cord-289034-yl3emjef	15	1	All	all	PDT
cord-289034-yl3emjef	15	2	the	the	DT
cord-289034-yl3emjef	15	3	other	other	JJ
cord-289034-yl3emjef	15	4	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	15	5	components	component	NNS
cord-289034-yl3emjef	15	6	are	be	VBP
cord-289034-yl3emjef	15	7	encoded	encode	VBN
cord-289034-yl3emjef	15	8	by	by	IN
cord-289034-yl3emjef	15	9	the	the	DT
cord-289034-yl3emjef	15	10	nuclear	nuclear	JJ
cord-289034-yl3emjef	15	11	genome	genome	NN
cord-289034-yl3emjef	15	12	.	.	.
cord-289034-yl3emjef	16	1	Mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	16	2	are	be	VBP
cord-289034-yl3emjef	16	3	the	the	DT
cord-289034-yl3emjef	16	4	energy	energy	NN
cord-289034-yl3emjef	16	5	powerhouses	powerhouse	NNS
cord-289034-yl3emjef	16	6	of	of	IN
cord-289034-yl3emjef	16	7	the	the	DT
cord-289034-yl3emjef	16	8	cell	cell	NN
cord-289034-yl3emjef	16	9	,	,	,
cord-289034-yl3emjef	16	10	being	be	VBG
cord-289034-yl3emjef	16	11	responsible	responsible	JJ
cord-289034-yl3emjef	16	12	for	for	IN
cord-289034-yl3emjef	16	13	90	90	CD
cord-289034-yl3emjef	16	14	%	%	NN
cord-289034-yl3emjef	16	15	of	of	IN
cord-289034-yl3emjef	16	16	energy	energy	NN
cord-289034-yl3emjef	16	17	production	production	NN
cord-289034-yl3emjef	16	18	in	in	IN
cord-289034-yl3emjef	16	19	the	the	DT
cord-289034-yl3emjef	16	20	form	form	NN
cord-289034-yl3emjef	16	21	of	of	IN
cord-289034-yl3emjef	16	22	ATP	ATP	NNP
cord-289034-yl3emjef	16	23	by	by	IN
cord-289034-yl3emjef	16	24	coupling	couple	VBG
cord-289034-yl3emjef	16	25	the	the	DT
cord-289034-yl3emjef	16	26	flux	flux	NN
cord-289034-yl3emjef	16	27	of	of	IN
cord-289034-yl3emjef	16	28	electrons	electron	NNS
cord-289034-yl3emjef	16	29	throughout	throughout	IN
cord-289034-yl3emjef	16	30	the	the	DT
cord-289034-yl3emjef	16	31	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	16	32	respiratory	respiratory	JJ
cord-289034-yl3emjef	16	33	complexes	complex	NNS
cord-289034-yl3emjef	16	34	I	I	NNP
cord-289034-yl3emjef	16	35	-	-	HYPH
cord-289034-yl3emjef	16	36	IV	IV	NNP
cord-289034-yl3emjef	16	37	with	with	IN
cord-289034-yl3emjef	16	38	oxidative	oxidative	JJ
cord-289034-yl3emjef	16	39	phosphorylation	phosphorylation	NN
cord-289034-yl3emjef	16	40	(	(	-LRB-
cord-289034-yl3emjef	16	41	OXPHOS	OXPHOS	NNP
cord-289034-yl3emjef	16	42	)	)	-RRB-
cord-289034-yl3emjef	16	43	.	.	.
cord-289034-yl3emjef	17	1	In	in	IN
cord-289034-yl3emjef	17	2	brief	brief	JJ
cord-289034-yl3emjef	17	3	,	,	,
cord-289034-yl3emjef	17	4	complete	complete	JJ
cord-289034-yl3emjef	17	5	oxidation	oxidation	NN
cord-289034-yl3emjef	17	6	of	of	IN
cord-289034-yl3emjef	17	7	nutrients	nutrient	NNS
cord-289034-yl3emjef	17	8	through	through	IN
cord-289034-yl3emjef	17	9	the	the	DT
cord-289034-yl3emjef	17	10	tricarboxylic	tricarboxylic	JJ
cord-289034-yl3emjef	17	11	acid	acid	NN
cord-289034-yl3emjef	17	12	cycle	cycle	NN
cord-289034-yl3emjef	17	13	(	(	-LRB-
cord-289034-yl3emjef	17	14	TCA	TCA	NNP
cord-289034-yl3emjef	17	15	)	)	-RRB-
cord-289034-yl3emjef	17	16	within	within	IN
cord-289034-yl3emjef	17	17	mitochondria	mitochondria	NN
cord-289034-yl3emjef	17	18	produces	produce	VBZ
cord-289034-yl3emjef	17	19	reduced	reduce	VBN
cord-289034-yl3emjef	17	20	coenzymes	coenzyme	NNS
cord-289034-yl3emjef	17	21	(	(	-LRB-
cord-289034-yl3emjef	17	22	NADH	NADH	NNP
cord-289034-yl3emjef	17	23	,	,	,
cord-289034-yl3emjef	17	24	FADH2	FADH2	NNP
cord-289034-yl3emjef	17	25	)	)	-RRB-
cord-289034-yl3emjef	18	1	that	that	DT
cord-289034-yl3emjef	18	2	act	act	NN
cord-289034-yl3emjef	18	3	as	as	IN
cord-289034-yl3emjef	18	4	electron	electron	NN
cord-289034-yl3emjef	18	5	donors	donor	NNS
cord-289034-yl3emjef	18	6	.	.	.
cord-289034-yl3emjef	19	1	The	the	DT
cord-289034-yl3emjef	19	2	flux	flux	NN
cord-289034-yl3emjef	19	3	of	of	IN
cord-289034-yl3emjef	19	4	electrons	electron	NNS
cord-289034-yl3emjef	19	5	through	through	IN
cord-289034-yl3emjef	19	6	the	the	DT
cord-289034-yl3emjef	19	7	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	19	8	respiratory	respiratory	JJ
cord-289034-yl3emjef	19	9	chain	chain	NN
cord-289034-yl3emjef	19	10	complexes	complex	NNS
cord-289034-yl3emjef	19	11	produces	produce	VBZ
cord-289034-yl3emjef	19	12	an	an	DT
cord-289034-yl3emjef	19	13	electrochemical	electrochemical	JJ
cord-289034-yl3emjef	19	14	gradient	gradient	NN
cord-289034-yl3emjef	19	15	used	use	VBN
cord-289034-yl3emjef	19	16	by	by	IN
cord-289034-yl3emjef	19	17	the	the	DT
cord-289034-yl3emjef	19	18	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	19	19	respiratory	respiratory	JJ
cord-289034-yl3emjef	19	20	Complex	complex	NN
cord-289034-yl3emjef	19	21	V	v	NN
cord-289034-yl3emjef	19	22	to	to	TO
cord-289034-yl3emjef	19	23	generate	generate	VB
cord-289034-yl3emjef	19	24	ATP	ATP	NNP
cord-289034-yl3emjef	19	25	.	.	.
cord-289034-yl3emjef	20	1	Notably	notably	RB
cord-289034-yl3emjef	20	2	,	,	,
cord-289034-yl3emjef	20	3	the	the	DT
cord-289034-yl3emjef	20	4	function	function	NN
cord-289034-yl3emjef	20	5	of	of	IN
cord-289034-yl3emjef	20	6	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	20	7	in	in	IN
cord-289034-yl3emjef	20	8	cell	cell	NN
cord-289034-yl3emjef	20	9	physiology	physiology	NN
cord-289034-yl3emjef	20	10	goes	go	VBZ
cord-289034-yl3emjef	20	11	beyond	beyond	IN
cord-289034-yl3emjef	20	12	their	-PRON-	PRP$
cord-289034-yl3emjef	20	13	role	role	NN
cord-289034-yl3emjef	20	14	as	as	IN
cord-289034-yl3emjef	20	15	energy	energy	NN
cord-289034-yl3emjef	20	16	producers	producer	NNS
cord-289034-yl3emjef	20	17	and	and	CC
cord-289034-yl3emjef	20	18	metabolic	metabolic	JJ
cord-289034-yl3emjef	20	19	regulators	regulator	NNS
cord-289034-yl3emjef	20	20	.	.	.
cord-289034-yl3emjef	21	1	Indeed	indeed	RB
cord-289034-yl3emjef	21	2	,	,	,
cord-289034-yl3emjef	21	3	these	these	DT
cord-289034-yl3emjef	21	4	multifaceted	multifaceted	JJ
cord-289034-yl3emjef	21	5	organelles	organelle	NNS
cord-289034-yl3emjef	21	6	play	play	VBP
cord-289034-yl3emjef	21	7	a	a	DT
cord-289034-yl3emjef	21	8	pivotal	pivotal	JJ
cord-289034-yl3emjef	21	9	role	role	NN
cord-289034-yl3emjef	21	10	in	in	IN
cord-289034-yl3emjef	21	11	the	the	DT
cord-289034-yl3emjef	21	12	modulation	modulation	NN
cord-289034-yl3emjef	21	13	of	of	IN
cord-289034-yl3emjef	21	14	cell	cell	NN
cord-289034-yl3emjef	21	15	death	death	NN
cord-289034-yl3emjef	21	16	pathways	pathway	NNS
cord-289034-yl3emjef	21	17	and	and	CC
cord-289034-yl3emjef	21	18	intracellular	intracellular	JJ
cord-289034-yl3emjef	21	19	signaling	signal	VBG
cord-289034-yl3emjef	21	20	[	[	-LRB-
cord-289034-yl3emjef	21	21	1	1	CD
cord-289034-yl3emjef	21	22	]	]	-RRB-
cord-289034-yl3emjef	21	23	.	.	.
cord-289034-yl3emjef	22	1	The	the	DT
cord-289034-yl3emjef	22	2	ETC	ETC	NNP
cord-289034-yl3emjef	22	3	is	be	VBZ
cord-289034-yl3emjef	22	4	also	also	RB
cord-289034-yl3emjef	22	5	the	the	DT
cord-289034-yl3emjef	22	6	main	main	JJ
cord-289034-yl3emjef	22	7	cellular	cellular	JJ
cord-289034-yl3emjef	22	8	source	source	NN
cord-289034-yl3emjef	22	9	of	of	IN
cord-289034-yl3emjef	22	10	reactive	reactive	JJ
cord-289034-yl3emjef	22	11	oxygen	oxygen	NN
cord-289034-yl3emjef	22	12	species	specie	NNS
cord-289034-yl3emjef	22	13	(	(	-LRB-
cord-289034-yl3emjef	22	14	ROS	ROS	NNP
cord-289034-yl3emjef	22	15	)	)	-RRB-
cord-289034-yl3emjef	22	16	,	,	,
cord-289034-yl3emjef	22	17	owing	owe	VBG
cord-289034-yl3emjef	22	18	to	to	IN
cord-289034-yl3emjef	22	19	an	an	DT
cord-289034-yl3emjef	22	20	incomplete	incomplete	JJ
cord-289034-yl3emjef	22	21	reduction	reduction	NN
cord-289034-yl3emjef	22	22	of	of	IN
cord-289034-yl3emjef	22	23	oxygen	oxygen	NN
cord-289034-yl3emjef	22	24	by	by	IN
cord-289034-yl3emjef	22	25	Complex	Complex	NNP
cord-289034-yl3emjef	22	26	I	I	NNP
cord-289034-yl3emjef	22	27	and	and	CC
cord-289034-yl3emjef	22	28	Complex	Complex	NNP
cord-289034-yl3emjef	22	29	III	III	NNP
cord-289034-yl3emjef	22	30	.	.	.
cord-289034-yl3emjef	23	1	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	23	2	ROS	ROS	NNP
cord-289034-yl3emjef	23	3	production	production	NN
cord-289034-yl3emjef	23	4	can	can	MD
cord-289034-yl3emjef	23	5	lead	lead	VB
cord-289034-yl3emjef	23	6	to	to	IN
cord-289034-yl3emjef	23	7	oxidative	oxidative	JJ
cord-289034-yl3emjef	23	8	damage	damage	NN
cord-289034-yl3emjef	23	9	to	to	IN
cord-289034-yl3emjef	23	10	proteins	protein	NNS
cord-289034-yl3emjef	23	11	,	,	,
cord-289034-yl3emjef	23	12	membranes	membrane	NNS
cord-289034-yl3emjef	23	13	and	and	CC
cord-289034-yl3emjef	23	14	DNA	dna	NN
cord-289034-yl3emjef	23	15	,	,	,
cord-289034-yl3emjef	23	16	thus	thus	RB
cord-289034-yl3emjef	23	17	impairing	impair	VBG
cord-289034-yl3emjef	23	18	the	the	DT
cord-289034-yl3emjef	23	19	ability	ability	NN
cord-289034-yl3emjef	23	20	of	of	IN
cord-289034-yl3emjef	23	21	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	23	22	to	to	TO
cord-289034-yl3emjef	23	23	carry	carry	VB
cord-289034-yl3emjef	23	24	out	out	RP
cord-289034-yl3emjef	23	25	their	-PRON-	PRP$
cord-289034-yl3emjef	23	26	biosynthetic	biosynthetic	JJ
cord-289034-yl3emjef	23	27	and	and	CC
cord-289034-yl3emjef	23	28	catabolic	catabolic	JJ
cord-289034-yl3emjef	23	29	reactions	reaction	NNS
cord-289034-yl3emjef	23	30	,	,	,
cord-289034-yl3emjef	23	31	including	include	VBG
cord-289034-yl3emjef	23	32	the	the	DT
cord-289034-yl3emjef	23	33	TCA	TCA	NNP
cord-289034-yl3emjef	23	34	cycle	cycle	NN
cord-289034-yl3emjef	23	35	,	,	,
cord-289034-yl3emjef	23	36	heme	heme	NN
cord-289034-yl3emjef	23	37	synthesis	synthesis	NN
cord-289034-yl3emjef	23	38	,	,	,
cord-289034-yl3emjef	23	39	fatty	fatty	JJ
cord-289034-yl3emjef	23	40	acid	acid	NN
cord-289034-yl3emjef	23	41	oxidation	oxidation	NN
cord-289034-yl3emjef	23	42	,	,	,
cord-289034-yl3emjef	23	43	the	the	DT
cord-289034-yl3emjef	23	44	urea	urea	NN
cord-289034-yl3emjef	23	45	cycle	cycle	NN
cord-289034-yl3emjef	23	46	and	and	CC
cord-289034-yl3emjef	23	47	amino	amino	NN
cord-289034-yl3emjef	23	48	acid	acid	NN
cord-289034-yl3emjef	23	49	metabolism	metabolism	NN
cord-289034-yl3emjef	23	50	[	[	-LRB-
cord-289034-yl3emjef	23	51	2	2	CD
cord-289034-yl3emjef	23	52	]	]	-RRB-
cord-289034-yl3emjef	23	53	.	.	.
cord-289034-yl3emjef	24	1	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	24	2	oxidative	oxidative	JJ
cord-289034-yl3emjef	24	3	damage	damage	NN
cord-289034-yl3emjef	24	4	can	can	MD
cord-289034-yl3emjef	24	5	also	also	RB
cord-289034-yl3emjef	24	6	promote	promote	VB
cord-289034-yl3emjef	24	7	permeabilization	permeabilization	NN
cord-289034-yl3emjef	24	8	of	of	IN
cord-289034-yl3emjef	24	9	the	the	DT
cord-289034-yl3emjef	24	10	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	24	11	outer	outer	JJ
cord-289034-yl3emjef	24	12	membrane	membrane	NN
cord-289034-yl3emjef	24	13	(	(	-LRB-
cord-289034-yl3emjef	24	14	MOMP	MOMP	NNP
cord-289034-yl3emjef	24	15	)	)	-RRB-
cord-289034-yl3emjef	24	16	,	,	,
cord-289034-yl3emjef	24	17	resulting	result	VBG
cord-289034-yl3emjef	24	18	in	in	IN
cord-289034-yl3emjef	24	19	release	release	NN
cord-289034-yl3emjef	24	20	of	of	IN
cord-289034-yl3emjef	24	21	intermembrane	intermembrane	NNP
cord-289034-yl3emjef	24	22	space	space	NN
cord-289034-yl3emjef	24	23	proteins	protein	NNS
cord-289034-yl3emjef	24	24	,	,	,
cord-289034-yl3emjef	24	25	such	such	JJ
cord-289034-yl3emjef	24	26	as	as	IN
cord-289034-yl3emjef	24	27	cytochrome	cytochrome	NN
cord-289034-yl3emjef	24	28	c	c	NN
cord-289034-yl3emjef	24	29	,	,	,
cord-289034-yl3emjef	24	30	and	and	CC
cord-289034-yl3emjef	24	31	activation	activation	NN
cord-289034-yl3emjef	24	32	of	of	IN
cord-289034-yl3emjef	24	33	the	the	DT
cord-289034-yl3emjef	24	34	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	24	35	apoptotic	apoptotic	JJ
cord-289034-yl3emjef	24	36	pathway	pathway	NN
cord-289034-yl3emjef	24	37	.	.	.
cord-289034-yl3emjef	25	1	Furthermore	furthermore	RB
cord-289034-yl3emjef	25	2	,	,	,
cord-289034-yl3emjef	25	3	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	25	4	ROS	ROS	NNP
cord-289034-yl3emjef	25	5	production	production	NN
cord-289034-yl3emjef	25	6	promotes	promote	VBZ
cord-289034-yl3emjef	25	7	the	the	DT
cord-289034-yl3emjef	25	8	opening	opening	NN
cord-289034-yl3emjef	25	9	of	of	IN
cord-289034-yl3emjef	25	10	the	the	DT
cord-289034-yl3emjef	25	11	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	25	12	permeability	permeability	NN
cord-289034-yl3emjef	25	13	transition	transition	NN
cord-289034-yl3emjef	25	14	pore	pore	NN
cord-289034-yl3emjef	25	15	(	(	-LRB-
cord-289034-yl3emjef	25	16	mPTP	mPTP	NNP
cord-289034-yl3emjef	25	17	)	)	-RRB-
cord-289034-yl3emjef	25	18	,	,	,
cord-289034-yl3emjef	25	19	leading	lead	VBG
cord-289034-yl3emjef	25	20	to	to	IN
cord-289034-yl3emjef	25	21	permeabilization	permeabilization	NN
cord-289034-yl3emjef	25	22	of	of	IN
cord-289034-yl3emjef	25	23	the	the	DT
cord-289034-yl3emjef	25	24	inner	inner	JJ
cord-289034-yl3emjef	25	25	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	25	26	membrane	membrane	NN
cord-289034-yl3emjef	25	27	to	to	IN
cord-289034-yl3emjef	25	28	small	small	JJ
cord-289034-yl3emjef	25	29	molecules	molecule	NNS
cord-289034-yl3emjef	25	30	in	in	IN
cord-289034-yl3emjef	25	31	pathological	pathological	JJ
cord-289034-yl3emjef	25	32	conditions	condition	NNS
cord-289034-yl3emjef	25	33	,	,	,
cord-289034-yl3emjef	25	34	such	such	JJ
cord-289034-yl3emjef	25	35	as	as	IN
cord-289034-yl3emjef	25	36	during	during	IN
cord-289034-yl3emjef	25	37	ischaemia	ischaemia	NN
cord-289034-yl3emjef	25	38	(	(	-LRB-
cord-289034-yl3emjef	25	39	loss	loss	NN
cord-289034-yl3emjef	25	40	of	of	IN
cord-289034-yl3emjef	25	41	blood	blood	NN
cord-289034-yl3emjef	25	42	flow	flow	NN
cord-289034-yl3emjef	25	43	)	)	-RRB-
cord-289034-yl3emjef	25	44	and	and	CC
cord-289034-yl3emjef	25	45	subsequent	subsequent	JJ
cord-289034-yl3emjef	25	46	reperfusion	reperfusion	NN
cord-289034-yl3emjef	25	47	[	[	-LRB-
cord-289034-yl3emjef	25	48	3	3	CD
cord-289034-yl3emjef	25	49	]	]	-RRB-
cord-289034-yl3emjef	25	50	.	.	.
cord-289034-yl3emjef	26	1	Two	two	CD
cord-289034-yl3emjef	26	2	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	26	3	quality	quality	NN
cord-289034-yl3emjef	26	4	control	control	NN
cord-289034-yl3emjef	26	5	mechanisms	mechanism	NNS
cord-289034-yl3emjef	26	6	are	be	VBP
cord-289034-yl3emjef	26	7	in	in	IN
cord-289034-yl3emjef	26	8	place	place	NN
cord-289034-yl3emjef	26	9	to	to	TO
cord-289034-yl3emjef	26	10	meet	meet	VB
cord-289034-yl3emjef	26	11	the	the	DT
cord-289034-yl3emjef	26	12	functional	functional	JJ
cord-289034-yl3emjef	26	13	needs	need	NNS
cord-289034-yl3emjef	26	14	of	of	IN
cord-289034-yl3emjef	26	15	any	any	DT
cord-289034-yl3emjef	26	16	given	give	VBN
cord-289034-yl3emjef	26	17	cell	cell	NN
cord-289034-yl3emjef	26	18	under	under	IN
cord-289034-yl3emjef	26	19	different	different	JJ
cord-289034-yl3emjef	26	20	physiological	physiological	JJ
cord-289034-yl3emjef	26	21	and	and	CC
cord-289034-yl3emjef	26	22	pathological	pathological	JJ
cord-289034-yl3emjef	26	23	conditions	condition	NNS
cord-289034-yl3emjef	26	24	:	:	:
cord-289034-yl3emjef	26	25	(	(	-LRB-
cord-289034-yl3emjef	26	26	a	a	LS
cord-289034-yl3emjef	26	27	)	)	-RRB-
cord-289034-yl3emjef	27	1	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	27	2	biogenesis	biogenesis	NN
cord-289034-yl3emjef	27	3	,	,	,
cord-289034-yl3emjef	27	4	fusion	fusion	NN
cord-289034-yl3emjef	27	5	and	and	CC
cord-289034-yl3emjef	27	6	fission	fission	NN
cord-289034-yl3emjef	27	7	[	[	-LRB-
cord-289034-yl3emjef	27	8	4	4	CD
cord-289034-yl3emjef	27	9	]	]	-RRB-
cord-289034-yl3emjef	27	10	[	[	-LRB-
cord-289034-yl3emjef	27	11	5	5	CD
cord-289034-yl3emjef	27	12	]	]	-RRB-
cord-289034-yl3emjef	27	13	[	[	-LRB-
cord-289034-yl3emjef	27	14	6	6	CD
cord-289034-yl3emjef	27	15	]	]	-RRB-
cord-289034-yl3emjef	27	16	;	;	.
cord-289034-yl3emjef	28	1	(	(	-LRB-
cord-289034-yl3emjef	28	2	b	b	LS
cord-289034-yl3emjef	28	3	)	)	-RRB-
cord-289034-yl3emjef	28	4	mitophagy	mitophagy	NNP
cord-289034-yl3emjef	28	5	[	[	-LRB-
cord-289034-yl3emjef	28	6	7	7	CD
cord-289034-yl3emjef	28	7	,	,	,
cord-289034-yl3emjef	28	8	8	8	CD
cord-289034-yl3emjef	28	9	]	]	-RRB-
cord-289034-yl3emjef	28	10	.	.	.
cord-289034-yl3emjef	29	1	The	the	DT
cord-289034-yl3emjef	29	2	first	first	JJ
cord-289034-yl3emjef	29	3	mechanism	mechanism	NN
cord-289034-yl3emjef	29	4	is	be	VBZ
cord-289034-yl3emjef	29	5	a	a	DT
cord-289034-yl3emjef	29	6	balanced	balanced	JJ
cord-289034-yl3emjef	29	7	process	process	NN
cord-289034-yl3emjef	29	8	that	that	WDT
cord-289034-yl3emjef	29	9	allows	allow	VBZ
cord-289034-yl3emjef	29	10	maintenance	maintenance	NN
cord-289034-yl3emjef	29	11	of	of	IN
cord-289034-yl3emjef	29	12	the	the	DT
cord-289034-yl3emjef	29	13	physiological	physiological	JJ
cord-289034-yl3emjef	29	14	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	29	15	homeostasis	homeostasis	NN
cord-289034-yl3emjef	29	16	when	when	WRB
cord-289034-yl3emjef	29	17	cells	cell	NNS
cord-289034-yl3emjef	29	18	face	face	VBP
cord-289034-yl3emjef	29	19	metabolic	metabolic	JJ
cord-289034-yl3emjef	29	20	or	or	CC
cord-289034-yl3emjef	29	21	microenvironmental	microenvironmental	JJ
cord-289034-yl3emjef	29	22	stresses	stress	NNS
cord-289034-yl3emjef	29	23	[	[	-LRB-
cord-289034-yl3emjef	29	24	9	9	CD
cord-289034-yl3emjef	29	25	]	]	-RRB-
cord-289034-yl3emjef	29	26	.	.	.
cord-289034-yl3emjef	30	1	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	30	2	fission	fission	NN
cord-289034-yl3emjef	30	3	guarantees	guarantee	VBZ
cord-289034-yl3emjef	30	4	an	an	DT
cord-289034-yl3emjef	30	5	adequate	adequate	JJ
cord-289034-yl3emjef	30	6	distribution	distribution	NN
cord-289034-yl3emjef	30	7	of	of	IN
cord-289034-yl3emjef	30	8	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	30	9	in	in	IN
cord-289034-yl3emjef	30	10	dividing	divide	VBG
cord-289034-yl3emjef	30	11	cells	cell	NNS
cord-289034-yl3emjef	30	12	.	.	.
cord-289034-yl3emjef	31	1	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	31	2	fusion	fusion	NN
cord-289034-yl3emjef	31	3	allows	allow	VBZ
cord-289034-yl3emjef	31	4	complementation	complementation	NN
cord-289034-yl3emjef	31	5	between	between	IN
cord-289034-yl3emjef	31	6	dysfunctional	dysfunctional	JJ
cord-289034-yl3emjef	31	7	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	31	8	within	within	IN
cord-289034-yl3emjef	31	9	the	the	DT
cord-289034-yl3emjef	31	10	cell	cell	NN
cord-289034-yl3emjef	31	11	to	to	TO
cord-289034-yl3emjef	31	12	maximize	maximize	VB
cord-289034-yl3emjef	31	13	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	31	14	performance	performance	NN
cord-289034-yl3emjef	31	15	in	in	IN
cord-289034-yl3emjef	31	16	response	response	NN
cord-289034-yl3emjef	31	17	to	to	IN
cord-289034-yl3emjef	31	18	stress	stress	NN
cord-289034-yl3emjef	31	19	.	.	.
cord-289034-yl3emjef	32	1	Three	three	CD
cord-289034-yl3emjef	32	2	GTPases	gtpase	NNS
cord-289034-yl3emjef	32	3	,	,	,
cord-289034-yl3emjef	32	4	mitofusin	mitofusin	NNP
cord-289034-yl3emjef	32	5	1	1	CD
cord-289034-yl3emjef	32	6	(	(	-LRB-
cord-289034-yl3emjef	32	7	Mfn1	Mfn1	NNP
cord-289034-yl3emjef	32	8	)	)	-RRB-
cord-289034-yl3emjef	32	9	,	,	,
cord-289034-yl3emjef	32	10	Mfn2	Mfn2	NNP
cord-289034-yl3emjef	32	11	,	,	,
cord-289034-yl3emjef	32	12	and	and	CC
cord-289034-yl3emjef	32	13	optic	optic	JJ
cord-289034-yl3emjef	32	14	atrophy	atrophy	NN
cord-289034-yl3emjef	32	15	1	1	CD
cord-289034-yl3emjef	33	1	(	(	-LRB-
cord-289034-yl3emjef	33	2	Opa1	Opa1	NNP
cord-289034-yl3emjef	33	3	)	)	-RRB-
cord-289034-yl3emjef	33	4	,	,	,
cord-289034-yl3emjef	33	5	are	be	VBP
cord-289034-yl3emjef	33	6	primarily	primarily	RB
cord-289034-yl3emjef	33	7	involved	involve	VBN
cord-289034-yl3emjef	33	8	in	in	IN
cord-289034-yl3emjef	33	9	the	the	DT
cord-289034-yl3emjef	33	10	regulation	regulation	NN
cord-289034-yl3emjef	33	11	of	of	IN
cord-289034-yl3emjef	33	12	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	33	13	fusion	fusion	NN
cord-289034-yl3emjef	33	14	.	.	.
cord-289034-yl3emjef	34	1	Instead	instead	RB
cord-289034-yl3emjef	34	2	,	,	,
cord-289034-yl3emjef	34	3	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	34	4	fission	fission	NN
cord-289034-yl3emjef	34	5	is	be	VBZ
cord-289034-yl3emjef	34	6	mainly	mainly	RB
cord-289034-yl3emjef	34	7	controlled	control	VBN
cord-289034-yl3emjef	34	8	by	by	IN
cord-289034-yl3emjef	34	9	the	the	DT
cord-289034-yl3emjef	34	10	GTPase	GTPase	NNP
cord-289034-yl3emjef	34	11	dynamin	dynamin	NN
cord-289034-yl3emjef	34	12	-	-	HYPH
cord-289034-yl3emjef	34	13	related	relate	VBN
cord-289034-yl3emjef	34	14	protein	protein	NN
cord-289034-yl3emjef	34	15	1	1	CD
cord-289034-yl3emjef	34	16	(	(	-LRB-
cord-289034-yl3emjef	34	17	Drp1	Drp1	NNP
cord-289034-yl3emjef	34	18	)	)	-RRB-
cord-289034-yl3emjef	34	19	[	[	-LRB-
cord-289034-yl3emjef	34	20	10	10	CD
cord-289034-yl3emjef	34	21	]	]	-RRB-
cord-289034-yl3emjef	34	22	.	.	.
cord-289034-yl3emjef	35	1	Disruption	disruption	NN
cord-289034-yl3emjef	35	2	of	of	IN
cord-289034-yl3emjef	35	3	the	the	DT
cord-289034-yl3emjef	35	4	balance	balance	NN
cord-289034-yl3emjef	35	5	between	between	IN
cord-289034-yl3emjef	35	6	fusion	fusion	NN
cord-289034-yl3emjef	35	7	and	and	CC
cord-289034-yl3emjef	35	8	fission	fission	NN
cord-289034-yl3emjef	35	9	is	be	VBZ
cord-289034-yl3emjef	35	10	associated	associate	VBN
cord-289034-yl3emjef	35	11	with	with	IN
cord-289034-yl3emjef	35	12	neurodegenerative	neurodegenerative	JJ
cord-289034-yl3emjef	35	13	diseases	disease	NNS
cord-289034-yl3emjef	35	14	,	,	,
cord-289034-yl3emjef	35	15	such	such	JJ
cord-289034-yl3emjef	35	16	as	as	IN
cord-289034-yl3emjef	35	17	Parkinson	Parkinson	NNP
cord-289034-yl3emjef	35	18	's	's	POS
cord-289034-yl3emjef	35	19	,	,	,
cord-289034-yl3emjef	35	20	and	and	CC
cord-289034-yl3emjef	35	21	cancer	cancer	NN
cord-289034-yl3emjef	35	22	[	[	-LRB-
cord-289034-yl3emjef	35	23	9	9	CD
cord-289034-yl3emjef	35	24	,	,	,
cord-289034-yl3emjef	35	25	10	10	CD
cord-289034-yl3emjef	35	26	]	]	-RRB-
cord-289034-yl3emjef	35	27	.	.	.
cord-289034-yl3emjef	36	1	The	the	DT
cord-289034-yl3emjef	36	2	second	second	JJ
cord-289034-yl3emjef	36	3	mechanism	mechanism	NN
cord-289034-yl3emjef	36	4	,	,	,
cord-289034-yl3emjef	36	5	mitophagy	mitophagy	NNP
cord-289034-yl3emjef	36	6	,	,	,
cord-289034-yl3emjef	36	7	is	be	VBZ
cord-289034-yl3emjef	36	8	a	a	DT
cord-289034-yl3emjef	36	9	specific	specific	JJ
cord-289034-yl3emjef	36	10	form	form	NN
cord-289034-yl3emjef	36	11	of	of	IN
cord-289034-yl3emjef	36	12	autophagy	autophagy	NN
cord-289034-yl3emjef	36	13	that	that	WDT
cord-289034-yl3emjef	36	14	removes	remove	VBZ
cord-289034-yl3emjef	36	15	damaged	damaged	JJ
cord-289034-yl3emjef	36	16	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	36	17	and	and	CC
cord-289034-yl3emjef	36	18	reduces	reduce	VBZ
cord-289034-yl3emjef	36	19	the	the	DT
cord-289034-yl3emjef	36	20	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	36	21	mass	mass	NN
cord-289034-yl3emjef	36	22	upon	upon	IN
cord-289034-yl3emjef	36	23	microenvironmental	microenvironmental	NNP
cord-289034-yl3emjef	36	24	stresses	stress	NNS
cord-289034-yl3emjef	36	25	,	,	,
cord-289034-yl3emjef	36	26	such	such	JJ
cord-289034-yl3emjef	36	27	as	as	IN
cord-289034-yl3emjef	36	28	hypoxia	hypoxia	NN
cord-289034-yl3emjef	36	29	and	and	CC
cord-289034-yl3emjef	36	30	nutrient	nutrient	NN
cord-289034-yl3emjef	36	31	starvation	starvation	NN
cord-289034-yl3emjef	36	32	,	,	,
cord-289034-yl3emjef	36	33	promoting	promote	VBG
cord-289034-yl3emjef	36	34	cell	cell	NN
cord-289034-yl3emjef	36	35	survival	survival	NN
cord-289034-yl3emjef	36	36	[	[	-LRB-
cord-289034-yl3emjef	36	37	11	11	CD
cord-289034-yl3emjef	36	38	]	]	-RRB-
cord-289034-yl3emjef	36	39	.	.	.
cord-289034-yl3emjef	37	1	Mitophagy	Mitophagy	NNP
cord-289034-yl3emjef	37	2	dysregulation	dysregulation	NN
cord-289034-yl3emjef	37	3	has	have	VBZ
cord-289034-yl3emjef	37	4	been	be	VBN
cord-289034-yl3emjef	37	5	implicated	implicate	VBN
cord-289034-yl3emjef	37	6	in	in	IN
cord-289034-yl3emjef	37	7	cancer	cancer	NN
cord-289034-yl3emjef	37	8	development	development	NN
cord-289034-yl3emjef	37	9	and	and	CC
cord-289034-yl3emjef	37	10	progression	progression	NN
cord-289034-yl3emjef	37	11	[	[	-LRB-
cord-289034-yl3emjef	37	12	12	12	CD
cord-289034-yl3emjef	37	13	]	]	-RRB-
cord-289034-yl3emjef	37	14	,	,	,
cord-289034-yl3emjef	37	15	neurodegeneration	neurodegeneration	NN
cord-289034-yl3emjef	37	16	[	[	-LRB-
cord-289034-yl3emjef	37	17	13	13	CD
cord-289034-yl3emjef	37	18	]	]	-RRB-
cord-289034-yl3emjef	37	19	and	and	CC
cord-289034-yl3emjef	37	20	cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	37	21	diseases	disease	NNS
cord-289034-yl3emjef	37	22	[	[	-LRB-
cord-289034-yl3emjef	37	23	7	7	CD
cord-289034-yl3emjef	37	24	]	]	-RRB-
cord-289034-yl3emjef	37	25	.	.	.
cord-289034-yl3emjef	38	1	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	38	2	dysfunction	dysfunction	NN
cord-289034-yl3emjef	38	3	can	can	MD
cord-289034-yl3emjef	38	4	lead	lead	VB
cord-289034-yl3emjef	38	5	to	to	IN
cord-289034-yl3emjef	38	6	an	an	DT
cord-289034-yl3emjef	38	7	array	array	NN
cord-289034-yl3emjef	38	8	of	of	IN
cord-289034-yl3emjef	38	9	diseases	disease	NNS
cord-289034-yl3emjef	38	10	.	.	.
cord-289034-yl3emjef	39	1	Depending	depend	VBG
cord-289034-yl3emjef	39	2	on	on	IN
cord-289034-yl3emjef	39	3	the	the	DT
cord-289034-yl3emjef	39	4	nature	nature	NN
cord-289034-yl3emjef	39	5	of	of	IN
cord-289034-yl3emjef	39	6	the	the	DT
cord-289034-yl3emjef	39	7	defect	defect	NN
cord-289034-yl3emjef	39	8	leading	lead	VBG
cord-289034-yl3emjef	39	9	to	to	IN
cord-289034-yl3emjef	39	10	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	39	11	dysfunction	dysfunction	NN
cord-289034-yl3emjef	39	12	,	,	,
cord-289034-yl3emjef	40	1	primary	primary	JJ
cord-289034-yl3emjef	40	2	and	and	CC
cord-289034-yl3emjef	40	3	secondary	secondary	JJ
cord-289034-yl3emjef	40	4	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	40	5	diseases	disease	NNS
cord-289034-yl3emjef	40	6	can	can	MD
cord-289034-yl3emjef	40	7	be	be	VB
cord-289034-yl3emjef	40	8	distinguished	distinguish	VBN
cord-289034-yl3emjef	40	9	.	.	.
cord-289034-yl3emjef	41	1	Primary	primary	JJ
cord-289034-yl3emjef	41	2	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	41	3	diseases	disease	NNS
cord-289034-yl3emjef	41	4	develop	develop	VBP
cord-289034-yl3emjef	41	5	as	as	IN
cord-289034-yl3emjef	41	6	a	a	DT
cord-289034-yl3emjef	41	7	consequence	consequence	NN
cord-289034-yl3emjef	41	8	of	of	IN
cord-289034-yl3emjef	41	9	germline	germline	JJ
cord-289034-yl3emjef	41	10	mutations	mutation	NNS
cord-289034-yl3emjef	41	11	in	in	IN
cord-289034-yl3emjef	41	12	mtDNA	mtDNA	NNP
cord-289034-yl3emjef	42	1	and/or	and/or	CC
cord-289034-yl3emjef	42	2	nuclear	nuclear	JJ
cord-289034-yl3emjef	42	3	DNA	dna	NN
cord-289034-yl3emjef	42	4	genes	gene	NNS
cord-289034-yl3emjef	42	5	that	that	WDT
cord-289034-yl3emjef	42	6	encode	encode	VBP
cord-289034-yl3emjef	42	7	proteins	protein	NNS
cord-289034-yl3emjef	42	8	affecting	affect	VBG
cord-289034-yl3emjef	42	9	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	42	10	functionality	functionality	NN
cord-289034-yl3emjef	42	11	and	and	CC
cord-289034-yl3emjef	42	12	energy	energy	NN
cord-289034-yl3emjef	42	13	production	production	NN
cord-289034-yl3emjef	42	14	,	,	,
cord-289034-yl3emjef	42	15	including	include	VBG
cord-289034-yl3emjef	42	16	ETC	etc	NN
cord-289034-yl3emjef	42	17	proteins	protein	NNS
cord-289034-yl3emjef	42	18	and	and	CC
cord-289034-yl3emjef	42	19	proteins	protein	NNS
cord-289034-yl3emjef	42	20	involved	involve	VBN
cord-289034-yl3emjef	42	21	in	in	IN
cord-289034-yl3emjef	42	22	mtDNA	mtdna	NN
cord-289034-yl3emjef	42	23	replication	replication	NN
cord-289034-yl3emjef	42	24	,	,	,
cord-289034-yl3emjef	42	25	such	such	JJ
cord-289034-yl3emjef	42	26	as	as	IN
cord-289034-yl3emjef	42	27	POLG	POLG	NNP
cord-289034-yl3emjef	42	28	.	.	.
cord-289034-yl3emjef	43	1	The	the	DT
cord-289034-yl3emjef	43	2	first	first	JJ
cord-289034-yl3emjef	43	3	primary	primary	JJ
cord-289034-yl3emjef	43	4	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	43	5	disease	disease	NN
cord-289034-yl3emjef	43	6	was	be	VBD
cord-289034-yl3emjef	43	7	described	describe	VBN
cord-289034-yl3emjef	43	8	in	in	IN
cord-289034-yl3emjef	43	9	1962	1962	CD
cord-289034-yl3emjef	43	10	[	[	-LRB-
cord-289034-yl3emjef	43	11	14	14	CD
cord-289034-yl3emjef	43	12	]	]	-RRB-
cord-289034-yl3emjef	43	13	and	and	CC
cord-289034-yl3emjef	43	14	involved	involve	VBD
cord-289034-yl3emjef	43	15	a	a	DT
cord-289034-yl3emjef	43	16	35-year	35-year	JJ
cord-289034-yl3emjef	43	17	-	-	HYPH
cord-289034-yl3emjef	43	18	old	old	JJ
cord-289034-yl3emjef	43	19	woman	woman	NN
cord-289034-yl3emjef	43	20	displaying	display	VBG
cord-289034-yl3emjef	43	21	excessive	excessive	JJ
cord-289034-yl3emjef	43	22	perspiration	perspiration	NN
cord-289034-yl3emjef	43	23	,	,	,
cord-289034-yl3emjef	43	24	polyphagia	polyphagia	NNP
cord-289034-yl3emjef	43	25	,	,	,
cord-289034-yl3emjef	43	26	polydipsia	polydipsia	NN
cord-289034-yl3emjef	43	27	without	without	IN
cord-289034-yl3emjef	43	28	polyuria	polyuria	NN
cord-289034-yl3emjef	43	29	,	,	,
cord-289034-yl3emjef	43	30	asthenia	asthenia	NN
cord-289034-yl3emjef	43	31	and	and	CC
cord-289034-yl3emjef	43	32	decreased	decrease	VBD
cord-289034-yl3emjef	43	33	body	body	NN
cord-289034-yl3emjef	43	34	weight	weight	NN
cord-289034-yl3emjef	43	35	,	,	,
cord-289034-yl3emjef	43	36	symptoms	symptom	NNS
cord-289034-yl3emjef	43	37	that	that	WDT
cord-289034-yl3emjef	43	38	started	start	VBD
cord-289034-yl3emjef	43	39	when	when	WRB
cord-289034-yl3emjef	43	40	she	-PRON-	PRP
cord-289034-yl3emjef	43	41	was	be	VBD
cord-289034-yl3emjef	43	42	seven	seven	CD
cord-289034-yl3emjef	43	43	years	year	NNS
cord-289034-yl3emjef	43	44	old	old	JJ
cord-289034-yl3emjef	43	45	.	.	.
cord-289034-yl3emjef	44	1	In	in	IN
cord-289034-yl3emjef	44	2	addition	addition	NN
cord-289034-yl3emjef	44	3	,	,	,
cord-289034-yl3emjef	44	4	her	-PRON-	PRP$
cord-289034-yl3emjef	44	5	basal	basal	JJ
cord-289034-yl3emjef	44	6	metabolic	metabolic	JJ
cord-289034-yl3emjef	44	7	rate	rate	NN
cord-289034-yl3emjef	44	8	was	be	VBD
cord-289034-yl3emjef	44	9	+172	+172	NNP
cord-289034-yl3emjef	44	10	%	%	NN
cord-289034-yl3emjef	44	11	,	,	,
cord-289034-yl3emjef	44	12	and	and	CC
cord-289034-yl3emjef	44	13	she	-PRON-	PRP
cord-289034-yl3emjef	44	14	presented	present	VBD
cord-289034-yl3emjef	44	15	with	with	IN
cord-289034-yl3emjef	44	16	creatinuria	creatinuria	NNP
cord-289034-yl3emjef	44	17	,	,	,
cord-289034-yl3emjef	44	18	myopathy	myopathy	NN
cord-289034-yl3emjef	44	19	and	and	CC
cord-289034-yl3emjef	44	20	pathological	pathological	JJ
cord-289034-yl3emjef	44	21	cardiomyogram	cardiomyogram	NN
cord-289034-yl3emjef	44	22	.	.	.
cord-289034-yl3emjef	45	1	She	-PRON-	PRP
cord-289034-yl3emjef	45	2	was	be	VBD
cord-289034-yl3emjef	45	3	diagnosed	diagnose	VBN
cord-289034-yl3emjef	45	4	with	with	IN
cord-289034-yl3emjef	45	5	a	a	DT
cord-289034-yl3emjef	45	6	disorder	disorder	NN
cord-289034-yl3emjef	45	7	of	of	IN
cord-289034-yl3emjef	45	8	the	the	DT
cord-289034-yl3emjef	45	9	enzymatic	enzymatic	JJ
cord-289034-yl3emjef	45	10	organization	organization	NN
cord-289034-yl3emjef	45	11	of	of	IN
cord-289034-yl3emjef	45	12	the	the	DT
cord-289034-yl3emjef	45	13	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	45	14	.	.	.
cord-289034-yl3emjef	46	1	Studies	study	NNS
cord-289034-yl3emjef	46	2	with	with	IN
cord-289034-yl3emjef	46	3	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	46	4	isolated	isolate	VBN
cord-289034-yl3emjef	46	5	from	from	IN
cord-289034-yl3emjef	46	6	the	the	DT
cord-289034-yl3emjef	46	7	skeletal	skeletal	JJ
cord-289034-yl3emjef	46	8	muscle	muscle	NN
cord-289034-yl3emjef	46	9	of	of	IN
cord-289034-yl3emjef	46	10	this	this	DT
cord-289034-yl3emjef	46	11	hypermetabolic	hypermetabolic	NN
cord-289034-yl3emjef	46	12	patient	patient	JJ
cord-289034-yl3emjef	47	1	revealed	reveal	VBD
cord-289034-yl3emjef	47	2	OXPHOS	OXPHOS	NNP
cord-289034-yl3emjef	47	3	uncoupling	uncouple	VBG
cord-289034-yl3emjef	47	4	[	[	-LRB-
cord-289034-yl3emjef	47	5	14	14	CD
cord-289034-yl3emjef	47	6	]	]	-RRB-
cord-289034-yl3emjef	47	7	.	.	.
cord-289034-yl3emjef	48	1	Since	since	IN
cord-289034-yl3emjef	48	2	then	then	RB
cord-289034-yl3emjef	48	3	,	,	,
cord-289034-yl3emjef	48	4	a	a	DT
cord-289034-yl3emjef	48	5	range	range	NN
cord-289034-yl3emjef	48	6	of	of	IN
cord-289034-yl3emjef	48	7	primary	primary	JJ
cord-289034-yl3emjef	48	8	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	48	9	diseases	disease	NNS
cord-289034-yl3emjef	48	10	has	have	VBZ
cord-289034-yl3emjef	48	11	been	be	VBN
cord-289034-yl3emjef	48	12	described	describe	VBN
cord-289034-yl3emjef	48	13	(	(	-LRB-
cord-289034-yl3emjef	48	14	reviewed	review	VBN
cord-289034-yl3emjef	48	15	in	in	IN
cord-289034-yl3emjef	48	16	[	[	-LRB-
cord-289034-yl3emjef	48	17	15	15	CD
cord-289034-yl3emjef	48	18	]	]	-RRB-
cord-289034-yl3emjef	48	19	)	)	-RRB-
cord-289034-yl3emjef	48	20	.	.	.
cord-289034-yl3emjef	49	1	Secondary	secondary	JJ
cord-289034-yl3emjef	49	2	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	49	3	defects	defect	NNS
cord-289034-yl3emjef	49	4	can	can	MD
cord-289034-yl3emjef	49	5	be	be	VB
cord-289034-yl3emjef	49	6	caused	cause	VBN
cord-289034-yl3emjef	49	7	by	by	IN
cord-289034-yl3emjef	49	8	germline	germline	JJ
cord-289034-yl3emjef	49	9	mutations	mutation	NNS
cord-289034-yl3emjef	49	10	in	in	IN
cord-289034-yl3emjef	49	11	genes	gene	NNS
cord-289034-yl3emjef	49	12	not	not	RB
cord-289034-yl3emjef	49	13	involved	involve	VBN
cord-289034-yl3emjef	49	14	in	in	IN
cord-289034-yl3emjef	49	15	respiration	respiration	NN
cord-289034-yl3emjef	49	16	/	/	SYM
cord-289034-yl3emjef	49	17	oxidative	oxidative	JJ
cord-289034-yl3emjef	49	18	phosphorylation	phosphorylation	NN
cord-289034-yl3emjef	49	19	or	or	CC
cord-289034-yl3emjef	49	20	can	can	MD
cord-289034-yl3emjef	49	21	be	be	VB
cord-289034-yl3emjef	49	22	acquired	acquire	VBN
cord-289034-yl3emjef	49	23	during	during	IN
cord-289034-yl3emjef	49	24	the	the	DT
cord-289034-yl3emjef	49	25	lifetime	lifetime	NN
cord-289034-yl3emjef	49	26	upon	upon	IN
cord-289034-yl3emjef	49	27	environmental	environmental	JJ
cord-289034-yl3emjef	49	28	insults	insult	NNS
cord-289034-yl3emjef	49	29	.	.	.
cord-289034-yl3emjef	50	1	Notably	notably	RB
cord-289034-yl3emjef	50	2	,	,	,
cord-289034-yl3emjef	50	3	environmental	environmental	JJ
cord-289034-yl3emjef	50	4	stress	stress	NN
cord-289034-yl3emjef	50	5	can	can	MD
cord-289034-yl3emjef	50	6	induce	induce	VB
cord-289034-yl3emjef	50	7	mtDNA	mtdna	NN
cord-289034-yl3emjef	50	8	alterations	alteration	NNS
cord-289034-yl3emjef	50	9	leading	lead	VBG
cord-289034-yl3emjef	50	10	to	to	IN
cord-289034-yl3emjef	50	11	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	50	12	dysfunction	dysfunction	NN
cord-289034-yl3emjef	50	13	during	during	IN
cord-289034-yl3emjef	50	14	aging	age	VBG
cord-289034-yl3emjef	50	15	,	,	,
cord-289034-yl3emjef	50	16	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	50	17	response	response	NN
cord-289034-yl3emjef	50	18	,	,	,
cord-289034-yl3emjef	50	19	etc	etc	FW
cord-289034-yl3emjef	50	20	.	.	.
cord-289034-yl3emjef	51	1	[	[	-LRB-
cord-289034-yl3emjef	51	2	16	16	CD
cord-289034-yl3emjef	51	3	,	,	,
cord-289034-yl3emjef	51	4	17	17	CD
cord-289034-yl3emjef	51	5	]	]	-RRB-
cord-289034-yl3emjef	51	6	.	.	.
cord-289034-yl3emjef	52	1	From	from	IN
cord-289034-yl3emjef	52	2	a	a	DT
cord-289034-yl3emjef	52	3	pathological	pathological	JJ
cord-289034-yl3emjef	52	4	point	point	NN
cord-289034-yl3emjef	52	5	of	of	IN
cord-289034-yl3emjef	52	6	view	view	NN
cord-289034-yl3emjef	52	7	,	,	,
cord-289034-yl3emjef	52	8	primary	primary	JJ
cord-289034-yl3emjef	52	9	and	and	CC
cord-289034-yl3emjef	52	10	secondary	secondary	JJ
cord-289034-yl3emjef	52	11	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	52	12	diseases	disease	NNS
cord-289034-yl3emjef	52	13	can	can	MD
cord-289034-yl3emjef	52	14	cause	cause	VB
cord-289034-yl3emjef	52	15	very	very	RB
cord-289034-yl3emjef	52	16	similar	similar	JJ
cord-289034-yl3emjef	52	17	symptoms	symptom	NNS
cord-289034-yl3emjef	52	18	,	,	,
cord-289034-yl3emjef	52	19	sometimes	sometimes	RB
cord-289034-yl3emjef	52	20	making	make	VBG
cord-289034-yl3emjef	52	21	diagnosis	diagnosis	NN
cord-289034-yl3emjef	52	22	difficult	difficult	JJ
cord-289034-yl3emjef	52	23	.	.	.
cord-289034-yl3emjef	53	1	At	at	IN
cord-289034-yl3emjef	53	2	the	the	DT
cord-289034-yl3emjef	53	3	molecular	molecular	JJ
cord-289034-yl3emjef	53	4	level	level	NN
cord-289034-yl3emjef	53	5	,	,	,
cord-289034-yl3emjef	53	6	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	53	7	dysfunction	dysfunction	NN
cord-289034-yl3emjef	53	8	can	can	MD
cord-289034-yl3emjef	53	9	affect	affect	VB
cord-289034-yl3emjef	53	10	the	the	DT
cord-289034-yl3emjef	53	11	levels	level	NNS
cord-289034-yl3emjef	53	12	of	of	IN
cord-289034-yl3emjef	53	13	key	key	JJ
cord-289034-yl3emjef	53	14	intracellular	intracellular	JJ
cord-289034-yl3emjef	53	15	signaling	signal	VBG
cord-289034-yl3emjef	53	16	regulators	regulator	NNS
cord-289034-yl3emjef	53	17	,	,	,
cord-289034-yl3emjef	53	18	such	such	JJ
cord-289034-yl3emjef	53	19	as	as	IN
cord-289034-yl3emjef	53	20	ROS	ROS	NNP
cord-289034-yl3emjef	53	21	and	and	CC
cord-289034-yl3emjef	53	22	Ca	Ca	NNP
cord-289034-yl3emjef	53	23	2	2	CD
cord-289034-yl3emjef	54	1	+	+	UH
cord-289034-yl3emjef	54	2	,	,	,
cord-289034-yl3emjef	54	3	that	that	DT
cord-289034-yl3emjef	54	4	can	can	MD
cord-289034-yl3emjef	54	5	be	be	VB
cord-289034-yl3emjef	54	6	transmitted	transmit	VBN
cord-289034-yl3emjef	54	7	to	to	IN
cord-289034-yl3emjef	54	8	the	the	DT
cord-289034-yl3emjef	54	9	nucleus	nucleus	NN
cord-289034-yl3emjef	54	10	(	(	-LRB-
cord-289034-yl3emjef	54	11	mitochondria	mitochondria	NN
cord-289034-yl3emjef	54	12	-	-	HYPH
cord-289034-yl3emjef	54	13	to	to	IN
cord-289034-yl3emjef	54	14	-	-	HYPH
cord-289034-yl3emjef	54	15	nucleus	nucleus	NN
cord-289034-yl3emjef	54	16	signaling	signaling	NN
cord-289034-yl3emjef	54	17	or	or	CC
cord-289034-yl3emjef	54	18	retrograde	retrograde	JJ
cord-289034-yl3emjef	54	19	signaling	signaling	NN
cord-289034-yl3emjef	54	20	)	)	-RRB-
cord-289034-yl3emjef	54	21	resulting	result	VBG
cord-289034-yl3emjef	54	22	in	in	IN
cord-289034-yl3emjef	54	23	changes	change	NNS
cord-289034-yl3emjef	54	24	in	in	IN
cord-289034-yl3emjef	54	25	gene	gene	NN
cord-289034-yl3emjef	54	26	expression	expression	NN
cord-289034-yl3emjef	54	27	and	and	CC
cord-289034-yl3emjef	54	28	modulation	modulation	NN
cord-289034-yl3emjef	54	29	of	of	IN
cord-289034-yl3emjef	54	30	a	a	DT
cord-289034-yl3emjef	54	31	range	range	NN
cord-289034-yl3emjef	54	32	of	of	IN
cord-289034-yl3emjef	54	33	cellular	cellular	JJ
cord-289034-yl3emjef	54	34	functions	function	NNS
cord-289034-yl3emjef	54	35	[	[	-LRB-
cord-289034-yl3emjef	54	36	1	1	CD
cord-289034-yl3emjef	54	37	,	,	,
cord-289034-yl3emjef	54	38	[	[	-LRB-
cord-289034-yl3emjef	54	39	18	18	CD
cord-289034-yl3emjef	54	40	]	]	-RRB-
cord-289034-yl3emjef	54	41	[	[	-LRB-
cord-289034-yl3emjef	54	42	19	19	CD
cord-289034-yl3emjef	54	43	]	]	-RRB-
cord-289034-yl3emjef	54	44	[	[	-LRB-
cord-289034-yl3emjef	54	45	20	20	CD
cord-289034-yl3emjef	54	46	]	]	-RRB-
cord-289034-yl3emjef	54	47	.	.	.
cord-289034-yl3emjef	55	1	In	in	IN
cord-289034-yl3emjef	55	2	addition	addition	NN
cord-289034-yl3emjef	55	3	,	,	,
cord-289034-yl3emjef	55	4	the	the	DT
cord-289034-yl3emjef	55	5	release	release	NN
cord-289034-yl3emjef	55	6	of	of	IN
cord-289034-yl3emjef	55	7	mtDNA	mtdna	NN
cord-289034-yl3emjef	55	8	and	and	CC
cord-289034-yl3emjef	55	9	peptides	peptide	NNS
cord-289034-yl3emjef	55	10	from	from	IN
cord-289034-yl3emjef	55	11	the	the	DT
cord-289034-yl3emjef	55	12	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	55	13	matrix	matrix	NN
cord-289034-yl3emjef	55	14	can	can	MD
cord-289034-yl3emjef	55	15	activate	activate	VB
cord-289034-yl3emjef	55	16	an	an	DT
cord-289034-yl3emjef	55	17	immune	immune	JJ
cord-289034-yl3emjef	55	18	response	response	NN
cord-289034-yl3emjef	55	19	that	that	WDT
cord-289034-yl3emjef	55	20	promotes	promote	VBZ
cord-289034-yl3emjef	55	21	a	a	DT
cord-289034-yl3emjef	55	22	pro	pro	JJ
cord-289034-yl3emjef	55	23	-	-	JJ
cord-289034-yl3emjef	55	24	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	55	25	cascade	cascade	NN
cord-289034-yl3emjef	55	26	[	[	-LRB-
cord-289034-yl3emjef	55	27	21	21	CD
cord-289034-yl3emjef	55	28	]	]	-RRB-
cord-289034-yl3emjef	55	29	.	.	.
cord-289034-yl3emjef	56	1	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	56	2	metabolites	metabolite	NNS
cord-289034-yl3emjef	56	3	can	can	MD
cord-289034-yl3emjef	56	4	also	also	RB
cord-289034-yl3emjef	56	5	act	act	VB
cord-289034-yl3emjef	56	6	as	as	IN
cord-289034-yl3emjef	56	7	signaling	signal	VBG
cord-289034-yl3emjef	56	8	molecules	molecule	NNS
cord-289034-yl3emjef	56	9	and	and	CC
cord-289034-yl3emjef	56	10	epigenetic	epigenetic	JJ
cord-289034-yl3emjef	56	11	modulators	modulator	NNS
cord-289034-yl3emjef	56	12	.	.	.
cord-289034-yl3emjef	57	1	In	in	IN
cord-289034-yl3emjef	57	2	this	this	DT
cord-289034-yl3emjef	57	3	context	context	NN
cord-289034-yl3emjef	57	4	,	,	,
cord-289034-yl3emjef	57	5	citrate	citrate	NNP
cord-289034-yl3emjef	57	6	,	,	,
cord-289034-yl3emjef	57	7	an	an	DT
cord-289034-yl3emjef	57	8	intermediate	intermediate	NN
cord-289034-yl3emjef	57	9	of	of	IN
cord-289034-yl3emjef	57	10	the	the	DT
cord-289034-yl3emjef	57	11	TCA	TCA	NNP
cord-289034-yl3emjef	57	12	cycle	cycle	NN
cord-289034-yl3emjef	57	13	,	,	,
cord-289034-yl3emjef	57	14	represents	represent	VBZ
cord-289034-yl3emjef	57	15	the	the	DT
cord-289034-yl3emjef	57	16	major	major	JJ
cord-289034-yl3emjef	57	17	source	source	NN
cord-289034-yl3emjef	57	18	of	of	IN
cord-289034-yl3emjef	57	19	acetyl	acetyl	NN
cord-289034-yl3emjef	57	20	-	-	HYPH
cord-289034-yl3emjef	57	21	CoA	CoA	NNP
cord-289034-yl3emjef	57	22	for	for	IN
cord-289034-yl3emjef	57	23	protein	protein	NN
cord-289034-yl3emjef	57	24	acetylation	acetylation	NNP
cord-289034-yl3emjef	57	25	,	,	,
cord-289034-yl3emjef	57	26	a	a	DT
cord-289034-yl3emjef	57	27	co	co	NN
cord-289034-yl3emjef	57	28	-	-	NN
cord-289034-yl3emjef	57	29	and	and	CC
cord-289034-yl3emjef	57	30	post	post	JJ
cord-289034-yl3emjef	57	31	-	-	JJ
cord-289034-yl3emjef	57	32	translational	translational	JJ
cord-289034-yl3emjef	57	33	modification	modification	NN
cord-289034-yl3emjef	57	34	that	that	WDT
cord-289034-yl3emjef	57	35	regulates	regulate	VBZ
cord-289034-yl3emjef	57	36	protein	protein	NN
cord-289034-yl3emjef	57	37	levels	level	NNS
cord-289034-yl3emjef	57	38	and	and	CC
cord-289034-yl3emjef	57	39	intracellular	intracellular	JJ
cord-289034-yl3emjef	57	40	signaling	signaling	NN
cord-289034-yl3emjef	57	41	in	in	IN
cord-289034-yl3emjef	57	42	physiological	physiological	JJ
cord-289034-yl3emjef	57	43	and	and	CC
cord-289034-yl3emjef	57	44	pathological	pathological	JJ
cord-289034-yl3emjef	57	45	conditions	condition	NNS
cord-289034-yl3emjef	57	46	[	[	-LRB-
cord-289034-yl3emjef	57	47	22	22	CD
cord-289034-yl3emjef	57	48	]	]	-RRB-
cord-289034-yl3emjef	57	49	.	.	.
cord-289034-yl3emjef	58	1	Emerging	emerge	VBG
cord-289034-yl3emjef	58	2	data	datum	NNS
cord-289034-yl3emjef	58	3	have	have	VBP
cord-289034-yl3emjef	58	4	also	also	RB
cord-289034-yl3emjef	58	5	provided	provide	VBN
cord-289034-yl3emjef	58	6	new	new	JJ
cord-289034-yl3emjef	58	7	evidences	evidence	NNS
cord-289034-yl3emjef	58	8	of	of	IN
cord-289034-yl3emjef	58	9	connections	connection	NNS
cord-289034-yl3emjef	58	10	between	between	IN
cord-289034-yl3emjef	58	11	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	58	12	dynamics	dynamic	NNS
cord-289034-yl3emjef	58	13	and	and	CC
cord-289034-yl3emjef	58	14	physical	physical	JJ
cord-289034-yl3emjef	58	15	contacts	contact	NNS
cord-289034-yl3emjef	58	16	among	among	IN
cord-289034-yl3emjef	58	17	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	58	18	and	and	CC
cord-289034-yl3emjef	58	19	the	the	DT
cord-289034-yl3emjef	58	20	endoplasmic	endoplasmic	NN
cord-289034-yl3emjef	58	21	reticulum	reticulum	NN
cord-289034-yl3emjef	58	22	(	(	-LRB-
cord-289034-yl3emjef	58	23	ER	ER	NNP
cord-289034-yl3emjef	58	24	)	)	-RRB-
cord-289034-yl3emjef	58	25	,	,	,
cord-289034-yl3emjef	58	26	known	know	VBN
cord-289034-yl3emjef	58	27	as	as	IN
cord-289034-yl3emjef	58	28	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	58	29	-	-	HYPH
cord-289034-yl3emjef	58	30	associated	associate	VBN
cord-289034-yl3emjef	58	31	ER	ER	NNP
cord-289034-yl3emjef	58	32	membranes	membrane	NNS
cord-289034-yl3emjef	58	33	(	(	-LRB-
cord-289034-yl3emjef	58	34	MAMs	MAMs	NNP
cord-289034-yl3emjef	58	35	)	)	-RRB-
cord-289034-yl3emjef	58	36	,	,	,
cord-289034-yl3emjef	58	37	which	which	WDT
cord-289034-yl3emjef	58	38	can	can	MD
cord-289034-yl3emjef	58	39	finetune	finetune	VB
cord-289034-yl3emjef	58	40	the	the	DT
cord-289034-yl3emjef	58	41	mechanisms	mechanism	NNS
cord-289034-yl3emjef	58	42	of	of	IN
cord-289034-yl3emjef	58	43	regulation	regulation	NN
cord-289034-yl3emjef	58	44	of	of	IN
cord-289034-yl3emjef	58	45	energy	energy	NN
cord-289034-yl3emjef	58	46	production	production	NN
cord-289034-yl3emjef	58	47	,	,	,
cord-289034-yl3emjef	59	1	Ca	ca	NN
cord-289034-yl3emjef	59	2	2	2	CD
cord-289034-yl3emjef	59	3	+	+	CC
cord-289034-yl3emjef	59	4	homeostasis	homeostasis	NN
cord-289034-yl3emjef	59	5	,	,	,
cord-289034-yl3emjef	59	6	survival	survival	NN
cord-289034-yl3emjef	59	7	and	and	CC
cord-289034-yl3emjef	59	8	apoptosis	apoptosis	NN
cord-289034-yl3emjef	59	9	[	[	-LRB-
cord-289034-yl3emjef	59	10	23	23	CD
cord-289034-yl3emjef	59	11	]	]	-RRB-
cord-289034-yl3emjef	59	12	.	.	.
cord-289034-yl3emjef	60	1	Here	here	RB
cord-289034-yl3emjef	60	2	,	,	,
cord-289034-yl3emjef	60	3	a	a	DT
cord-289034-yl3emjef	60	4	synthetic	synthetic	JJ
cord-289034-yl3emjef	60	5	overview	overview	NN
cord-289034-yl3emjef	60	6	of	of	IN
cord-289034-yl3emjef	60	7	the	the	DT
cord-289034-yl3emjef	60	8	role	role	NN
cord-289034-yl3emjef	60	9	of	of	IN
cord-289034-yl3emjef	60	10	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	60	11	in	in	IN
cord-289034-yl3emjef	60	12	specific	specific	JJ
cord-289034-yl3emjef	60	13	physiopathological	physiopathological	JJ
cord-289034-yl3emjef	60	14	conditions	condition	NNS
cord-289034-yl3emjef	60	15	is	be	VBZ
cord-289034-yl3emjef	60	16	provided	provide	VBN
cord-289034-yl3emjef	60	17	(	(	-LRB-
cord-289034-yl3emjef	60	18	Figure	figure	NN
cord-289034-yl3emjef	60	19	1	1	CD
cord-289034-yl3emjef	60	20	)	)	-RRB-
cord-289034-yl3emjef	60	21	.	.	.
cord-289034-yl3emjef	60	22	 	 	_SP
cord-289034-yl3emjef	61	1	Cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	61	2	diseases	disease	NNS
cord-289034-yl3emjef	61	3	are	be	VBP
cord-289034-yl3emjef	61	4	a	a	DT
cord-289034-yl3emjef	61	5	leading	leading	JJ
cord-289034-yl3emjef	61	6	cause	cause	NN
cord-289034-yl3emjef	61	7	of	of	IN
cord-289034-yl3emjef	61	8	death	death	NN
cord-289034-yl3emjef	61	9	worldwide	worldwide	RB
cord-289034-yl3emjef	61	10	.	.	.
cord-289034-yl3emjef	62	1	This	this	DT
cord-289034-yl3emjef	62	2	class	class	NN
cord-289034-yl3emjef	62	3	of	of	IN
cord-289034-yl3emjef	62	4	diseases	disease	NNS
cord-289034-yl3emjef	62	5	comprises	comprise	VBZ
cord-289034-yl3emjef	62	6	several	several	JJ
cord-289034-yl3emjef	62	7	pathologies	pathology	NNS
cord-289034-yl3emjef	62	8	,	,	,
cord-289034-yl3emjef	62	9	including	include	VBG
cord-289034-yl3emjef	62	10	ischemic	ischemic	JJ
cord-289034-yl3emjef	62	11	heart	heart	NN
cord-289034-yl3emjef	62	12	disease	disease	NN
cord-289034-yl3emjef	62	13	,	,	,
cord-289034-yl3emjef	62	14	peripheral	peripheral	JJ
cord-289034-yl3emjef	62	15	vascular	vascular	JJ
cord-289034-yl3emjef	62	16	disease	disease	NN
cord-289034-yl3emjef	62	17	,	,	,
cord-289034-yl3emjef	62	18	cardiac	cardiac	JJ
cord-289034-yl3emjef	62	19	arrest	arrest	NN
cord-289034-yl3emjef	62	20	,	,	,
cord-289034-yl3emjef	62	21	heart	heart	NN
cord-289034-yl3emjef	62	22	failure	failure	NN
cord-289034-yl3emjef	62	23	,	,	,
cord-289034-yl3emjef	62	24	cardiomyopathies	cardiomyopathy	NNS
cord-289034-yl3emjef	62	25	,	,	,
cord-289034-yl3emjef	62	26	hypertension	hypertension	NN
cord-289034-yl3emjef	62	27	,	,	,
cord-289034-yl3emjef	62	28	atherosclerosis	atherosclerosis	NN
cord-289034-yl3emjef	62	29	,	,	,
cord-289034-yl3emjef	62	30	and	and	CC
cord-289034-yl3emjef	62	31	arrhythmia	arrhythmia	NN
cord-289034-yl3emjef	62	32	.	.	.
cord-289034-yl3emjef	63	1	Mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	63	2	have	have	VBP
cord-289034-yl3emjef	63	3	been	be	VBN
cord-289034-yl3emjef	63	4	involved	involve	VBN
cord-289034-yl3emjef	63	5	at	at	IN
cord-289034-yl3emjef	63	6	various	various	JJ
cord-289034-yl3emjef	63	7	degrees	degree	NNS
cord-289034-yl3emjef	63	8	in	in	IN
cord-289034-yl3emjef	63	9	the	the	DT
cord-289034-yl3emjef	63	10	pathological	pathological	JJ
cord-289034-yl3emjef	63	11	aspects	aspect	NNS
cord-289034-yl3emjef	63	12	of	of	IN
cord-289034-yl3emjef	63	13	these	these	DT
cord-289034-yl3emjef	63	14	diseases	disease	NNS
cord-289034-yl3emjef	63	15	.	.	.
cord-289034-yl3emjef	64	1	Notably	notably	RB
cord-289034-yl3emjef	64	2	,	,	,
cord-289034-yl3emjef	64	3	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	64	4	dysfunction	dysfunction	NN
cord-289034-yl3emjef	64	5	of	of	IN
cord-289034-yl3emjef	64	6	muscle	muscle	NN
cord-289034-yl3emjef	64	7	cells	cell	NNS
cord-289034-yl3emjef	64	8	represents	represent	VBZ
cord-289034-yl3emjef	64	9	a	a	DT
cord-289034-yl3emjef	64	10	key	key	JJ
cord-289034-yl3emjef	64	11	event	event	NN
cord-289034-yl3emjef	64	12	in	in	IN
cord-289034-yl3emjef	64	13	the	the	DT
cord-289034-yl3emjef	64	14	prognosis	prognosis	NN
cord-289034-yl3emjef	64	15	of	of	IN
cord-289034-yl3emjef	64	16	peripheral	peripheral	JJ
cord-289034-yl3emjef	64	17	arterial	arterial	JJ
cord-289034-yl3emjef	64	18	disease	disease	NN
cord-289034-yl3emjef	64	19	.	.	.
cord-289034-yl3emjef	65	1	Reduced	reduce	VBN
cord-289034-yl3emjef	65	2	OXPHOS	OXPHOS	NNP
cord-289034-yl3emjef	65	3	activity	activity	NN
cord-289034-yl3emjef	65	4	due	due	IN
cord-289034-yl3emjef	65	5	to	to	IN
cord-289034-yl3emjef	65	6	ETC	etc	FW
cord-289034-yl3emjef	65	7	impairment	impairment	NN
cord-289034-yl3emjef	65	8	increases	increase	VBZ
cord-289034-yl3emjef	65	9	ROS	ROS	NNP
cord-289034-yl3emjef	65	10	levels	level	NNS
cord-289034-yl3emjef	65	11	and	and	CC
cord-289034-yl3emjef	66	1	Ca	ca	NN
cord-289034-yl3emjef	66	2	2	2	CD
cord-289034-yl3emjef	66	3	+	+	CC
cord-289034-yl3emjef	66	4	release	release	NN
cord-289034-yl3emjef	66	5	from	from	IN
cord-289034-yl3emjef	66	6	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	66	7	,	,	.
cord-289034-yl3emjef	67	1	causing	cause	VBG
cord-289034-yl3emjef	67	2	apoptosis	apoptosis	NN
cord-289034-yl3emjef	67	3	[	[	-LRB-
cord-289034-yl3emjef	67	4	24	24	CD
cord-289034-yl3emjef	67	5	]	]	-RRB-
cord-289034-yl3emjef	67	6	.	.	.
cord-289034-yl3emjef	68	1	However	however	RB
cord-289034-yl3emjef	68	2	,	,	,
cord-289034-yl3emjef	68	3	if	if	IN
cord-289034-yl3emjef	68	4	ROS	ROS	NNP
cord-289034-yl3emjef	68	5	levels	level	NNS
cord-289034-yl3emjef	68	6	remain	remain	VBP
cord-289034-yl3emjef	68	7	below	below	IN
cord-289034-yl3emjef	68	8	a	a	DT
cord-289034-yl3emjef	68	9	threshold	threshold	NN
cord-289034-yl3emjef	68	10	,	,	,
cord-289034-yl3emjef	68	11	the	the	DT
cord-289034-yl3emjef	68	12	cells	cell	NNS
cord-289034-yl3emjef	68	13	activate	activate	VBP
cord-289034-yl3emjef	68	14	a	a	DT
cord-289034-yl3emjef	68	15	defense	defense	NN
cord-289034-yl3emjef	68	16	program	program	NN
cord-289034-yl3emjef	68	17	involving	involve	VBG
cord-289034-yl3emjef	68	18	production	production	NN
cord-289034-yl3emjef	68	19	of	of	IN
cord-289034-yl3emjef	68	20	antioxidants	antioxidant	NNS
cord-289034-yl3emjef	68	21	and	and	CC
cord-289034-yl3emjef	68	22	increased	increase	VBN
cord-289034-yl3emjef	68	23	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	68	24	biogenesis	biogenesis	NN
cord-289034-yl3emjef	68	25	.	.	.
cord-289034-yl3emjef	69	1	These	these	DT
cord-289034-yl3emjef	69	2	mechanisms	mechanism	NNS
cord-289034-yl3emjef	69	3	,	,	,
cord-289034-yl3emjef	69	4	known	know	VBN
cord-289034-yl3emjef	69	5	as	as	IN
cord-289034-yl3emjef	69	6	mitohormesis	mitohormesis	NN
cord-289034-yl3emjef	69	7	,	,	,
cord-289034-yl3emjef	69	8	can	can	MD
cord-289034-yl3emjef	69	9	limit	limit	VB
cord-289034-yl3emjef	69	10	the	the	DT
cord-289034-yl3emjef	69	11	damage	damage	NN
cord-289034-yl3emjef	69	12	caused	cause	VBN
cord-289034-yl3emjef	69	13	by	by	IN
cord-289034-yl3emjef	69	14	repeated	repeat	VBN
cord-289034-yl3emjef	69	15	cycles	cycle	NNS
cord-289034-yl3emjef	69	16	of	of	IN
cord-289034-yl3emjef	69	17	ischemia	ischemia	NN
cord-289034-yl3emjef	69	18	-	-	HYPH
cord-289034-yl3emjef	69	19	reperfusion	reperfusion	NN
cord-289034-yl3emjef	69	20	in	in	IN
cord-289034-yl3emjef	69	21	peripheral	peripheral	JJ
cord-289034-yl3emjef	69	22	arterial	arterial	JJ
cord-289034-yl3emjef	69	23	disease	disease	NN
cord-289034-yl3emjef	69	24	[	[	-LRB-
cord-289034-yl3emjef	69	25	24	24	CD
cord-289034-yl3emjef	69	26	]	]	-RRB-
cord-289034-yl3emjef	69	27	.	.	.
cord-289034-yl3emjef	70	1	Pharmacological	pharmacological	JJ
cord-289034-yl3emjef	70	2	treatments	treatment	NNS
cord-289034-yl3emjef	70	3	that	that	WDT
cord-289034-yl3emjef	70	4	can	can	MD
cord-289034-yl3emjef	70	5	improve	improve	VB
cord-289034-yl3emjef	70	6	mitohormesis	mitohormesis	NN
cord-289034-yl3emjef	70	7	might	may	MD
cord-289034-yl3emjef	70	8	be	be	VB
cord-289034-yl3emjef	70	9	a	a	DT
cord-289034-yl3emjef	70	10	promising	promising	JJ
cord-289034-yl3emjef	70	11	therapeutic	therapeutic	JJ
cord-289034-yl3emjef	70	12	approach	approach	NN
cord-289034-yl3emjef	70	13	for	for	IN
cord-289034-yl3emjef	70	14	peripheral	peripheral	JJ
cord-289034-yl3emjef	70	15	arterial	arterial	JJ
cord-289034-yl3emjef	70	16	disease	disease	NN
cord-289034-yl3emjef	70	17	and	and	CC
cord-289034-yl3emjef	70	18	other	other	JJ
cord-289034-yl3emjef	70	19	cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	70	20	diseases	disease	NNS
cord-289034-yl3emjef	70	21	.	.	.
cord-289034-yl3emjef	71	1	Disruption	disruption	NN
cord-289034-yl3emjef	71	2	of	of	IN
cord-289034-yl3emjef	71	3	mitophagy	mitophagy	NNP
cord-289034-yl3emjef	71	4	also	also	RB
cord-289034-yl3emjef	71	5	exacerbates	exacerbate	VBZ
cord-289034-yl3emjef	71	6	the	the	DT
cord-289034-yl3emjef	71	7	development	development	NN
cord-289034-yl3emjef	71	8	of	of	IN
cord-289034-yl3emjef	71	9	cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	71	10	diseases	disease	NNS
cord-289034-yl3emjef	71	11	[	[	-LRB-
cord-289034-yl3emjef	71	12	7	7	CD
cord-289034-yl3emjef	71	13	]	]	-RRB-
cord-289034-yl3emjef	71	14	.	.	.
cord-289034-yl3emjef	72	1	Growing	grow	VBG
cord-289034-yl3emjef	72	2	evidence	evidence	NN
cord-289034-yl3emjef	72	3	indicates	indicate	VBZ
cord-289034-yl3emjef	72	4	that	that	IN
cord-289034-yl3emjef	72	5	the	the	DT
cord-289034-yl3emjef	72	6	pharmacological	pharmacological	JJ
cord-289034-yl3emjef	72	7	targeting	targeting	NN
cord-289034-yl3emjef	72	8	of	of	IN
cord-289034-yl3emjef	72	9	the	the	DT
cord-289034-yl3emjef	72	10	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	72	11	with	with	IN
cord-289034-yl3emjef	72	12	drugs	drug	NNS
cord-289034-yl3emjef	72	13	/	/	SYM
cord-289034-yl3emjef	72	14	natural	natural	JJ
cord-289034-yl3emjef	72	15	compounds	compound	NNS
cord-289034-yl3emjef	72	16	able	able	JJ
cord-289034-yl3emjef	72	17	to	to	TO
cord-289034-yl3emjef	72	18	modulate	modulate	VB
cord-289034-yl3emjef	72	19	mitophagy	mitophagy	NN
cord-289034-yl3emjef	72	20	can	can	MD
cord-289034-yl3emjef	72	21	ameliorate	ameliorate	VB
cord-289034-yl3emjef	72	22	cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	72	23	disorders	disorder	NNS
cord-289034-yl3emjef	72	24	in	in	IN
cord-289034-yl3emjef	72	25	patients	patient	NNS
cord-289034-yl3emjef	72	26	and	and	CC
cord-289034-yl3emjef	72	27	be	be	VB
cord-289034-yl3emjef	72	28	cardioprotective	cardioprotective	JJ
cord-289034-yl3emjef	72	29	[	[	-LRB-
cord-289034-yl3emjef	72	30	7	7	CD
cord-289034-yl3emjef	72	31	,	,	,
cord-289034-yl3emjef	72	32	25	25	CD
cord-289034-yl3emjef	72	33	]	]	-RRB-
cord-289034-yl3emjef	72	34	.	.	.
cord-289034-yl3emjef	73	1	Future	future	JJ
cord-289034-yl3emjef	73	2	studies	study	NNS
cord-289034-yl3emjef	73	3	that	that	WDT
cord-289034-yl3emjef	73	4	aim	aim	VBP
cord-289034-yl3emjef	73	5	at	at	IN
cord-289034-yl3emjef	73	6	a	a	DT
cord-289034-yl3emjef	73	7	better	well	JJR
cord-289034-yl3emjef	73	8	understanding	understanding	NN
cord-289034-yl3emjef	73	9	the	the	DT
cord-289034-yl3emjef	73	10	pathogenesis	pathogenesis	NN
cord-289034-yl3emjef	73	11	of	of	IN
cord-289034-yl3emjef	73	12	some	some	DT
cord-289034-yl3emjef	73	13	cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	73	14	diseases	disease	NNS
cord-289034-yl3emjef	73	15	are	be	VBP
cord-289034-yl3emjef	73	16	crucial	crucial	JJ
cord-289034-yl3emjef	73	17	to	to	TO
cord-289034-yl3emjef	73	18	develop	develop	VB
cord-289034-yl3emjef	73	19	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	73	20	-	-	HYPH
cord-289034-yl3emjef	73	21	targeting	target	VBG
cord-289034-yl3emjef	73	22	drugs	drug	NNS
cord-289034-yl3emjef	73	23	in	in	IN
cord-289034-yl3emjef	73	24	the	the	DT
cord-289034-yl3emjef	73	25	clinic	clinic	NN
cord-289034-yl3emjef	73	26	.	.	.
cord-289034-yl3emjef	74	1	Inflammation	inflammation	NN
cord-289034-yl3emjef	74	2	is	be	VBZ
cord-289034-yl3emjef	74	3	a	a	DT
cord-289034-yl3emjef	74	4	complex	complex	JJ
cord-289034-yl3emjef	74	5	,	,	,
cord-289034-yl3emjef	74	6	protective	protective	JJ
cord-289034-yl3emjef	74	7	body	body	NN
cord-289034-yl3emjef	74	8	response	response	NN
cord-289034-yl3emjef	74	9	to	to	IN
cord-289034-yl3emjef	74	10	infections	infection	NNS
cord-289034-yl3emjef	74	11	and	and	CC
cord-289034-yl3emjef	74	12	tissue	tissue	NN
cord-289034-yl3emjef	74	13	damage	damage	NN
cord-289034-yl3emjef	74	14	.	.	.
cord-289034-yl3emjef	75	1	The	the	DT
cord-289034-yl3emjef	75	2	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	75	3	response	response	NN
cord-289034-yl3emjef	75	4	signals	signal	VBZ
cord-289034-yl3emjef	75	5	the	the	DT
cord-289034-yl3emjef	75	6	immune	immune	JJ
cord-289034-yl3emjef	75	7	system	system	NN
cord-289034-yl3emjef	75	8	to	to	TO
cord-289034-yl3emjef	75	9	repair	repair	VB
cord-289034-yl3emjef	75	10	damaged	damage	VBN
cord-289034-yl3emjef	75	11	tissue	tissue	NN
cord-289034-yl3emjef	75	12	and	and	CC
cord-289034-yl3emjef	75	13	defend	defend	VB
cord-289034-yl3emjef	75	14	against	against	IN
cord-289034-yl3emjef	75	15	pathogens	pathogen	NNS
cord-289034-yl3emjef	75	16	(	(	-LRB-
cord-289034-yl3emjef	75	17	viruses	virus	NNS
cord-289034-yl3emjef	75	18	,	,	,
cord-289034-yl3emjef	75	19	bacteria	bacteria	NNS
cord-289034-yl3emjef	75	20	,	,	,
cord-289034-yl3emjef	75	21	etc	etc	FW
cord-289034-yl3emjef	75	22	.	.	.
cord-289034-yl3emjef	75	23	)	)	-RRB-
cord-289034-yl3emjef	75	24	or	or	CC
cord-289034-yl3emjef	75	25	other	other	JJ
cord-289034-yl3emjef	75	26	harmful	harmful	JJ
cord-289034-yl3emjef	75	27	stimuli	stimulus	NNS
cord-289034-yl3emjef	75	28	through	through	IN
cord-289034-yl3emjef	75	29	secretion	secretion	NN
cord-289034-yl3emjef	75	30	of	of	IN
cord-289034-yl3emjef	75	31	specific	specific	JJ
cord-289034-yl3emjef	75	32	mediators	mediator	NNS
cord-289034-yl3emjef	75	33	.	.	.
cord-289034-yl3emjef	76	1	However	however	RB
cord-289034-yl3emjef	76	2	,	,	,
cord-289034-yl3emjef	76	3	when	when	WRB
cord-289034-yl3emjef	76	4	inflammation	inflammation	NN
cord-289034-yl3emjef	76	5	persists	persist	VBZ
cord-289034-yl3emjef	76	6	,	,	,
cord-289034-yl3emjef	76	7	it	-PRON-	PRP
cord-289034-yl3emjef	76	8	may	may	MD
cord-289034-yl3emjef	76	9	drive	drive	VB
cord-289034-yl3emjef	76	10	various	various	JJ
cord-289034-yl3emjef	76	11	diseases	disease	NNS
cord-289034-yl3emjef	76	12	and	and	CC
cord-289034-yl3emjef	76	13	tissue	tissue	NN
cord-289034-yl3emjef	76	14	damage	damage	NN
cord-289034-yl3emjef	76	15	.	.	.
cord-289034-yl3emjef	77	1	Mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	77	2	-	-	HYPH
cord-289034-yl3emjef	77	3	derived	derive	VBN
cord-289034-yl3emjef	77	4	ROS	ROS	NNP
cord-289034-yl3emjef	77	5	play	play	VB
cord-289034-yl3emjef	77	6	a	a	DT
cord-289034-yl3emjef	77	7	key	key	JJ
cord-289034-yl3emjef	77	8	role	role	NN
cord-289034-yl3emjef	77	9	in	in	IN
cord-289034-yl3emjef	77	10	the	the	DT
cord-289034-yl3emjef	77	11	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	77	12	response	response	NN
cord-289034-yl3emjef	77	13	.	.	.
cord-289034-yl3emjef	78	1	Notably	notably	RB
cord-289034-yl3emjef	78	2	,	,	,
cord-289034-yl3emjef	78	3	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	78	4	are	be	VBP
cord-289034-yl3emjef	78	5	considered	consider	VBN
cord-289034-yl3emjef	78	6	the	the	DT
cord-289034-yl3emjef	78	7	main	main	JJ
cord-289034-yl3emjef	78	8	drivers	driver	NNS
cord-289034-yl3emjef	78	9	of	of	IN
cord-289034-yl3emjef	78	10	the	the	DT
cord-289034-yl3emjef	78	11	NLRP3	nlrp3	NN
cord-289034-yl3emjef	78	12	(	(	-LRB-
cord-289034-yl3emjef	78	13	NOD-	NOD-	NNP
cord-289034-yl3emjef	78	14	,	,	,
cord-289034-yl3emjef	78	15	LRR	LRR	NNP
cord-289034-yl3emjef	78	16	-	-	HYPH
cord-289034-yl3emjef	78	17	and	and	CC
cord-289034-yl3emjef	78	18	pyrin	pyrin	NNP
cord-289034-yl3emjef	78	19	domain	domain	NN
cord-289034-yl3emjef	78	20	-	-	:
cord-289034-yl3emjef	78	21	containing	contain	VBG
cord-289034-yl3emjef	78	22	3	3	CD
cord-289034-yl3emjef	78	23	)	)	-RRB-
cord-289034-yl3emjef	78	24	inflammasome	inflammasome	NNP
cord-289034-yl3emjef	78	25	[	[	-LRB-
cord-289034-yl3emjef	78	26	26	26	CD
cord-289034-yl3emjef	78	27	]	]	-RRB-
cord-289034-yl3emjef	78	28	[	[	-LRB-
cord-289034-yl3emjef	78	29	27	27	CD
cord-289034-yl3emjef	78	30	]	]	-RRB-
cord-289034-yl3emjef	78	31	[	[	-LRB-
cord-289034-yl3emjef	78	32	28	28	CD
cord-289034-yl3emjef	78	33	]	]	-RRB-
cord-289034-yl3emjef	78	34	[	[	-LRB-
cord-289034-yl3emjef	78	35	29	29	CD
cord-289034-yl3emjef	78	36	]	]	-RRB-
cord-289034-yl3emjef	78	37	,	,	,
cord-289034-yl3emjef	78	38	representing	represent	VBG
cord-289034-yl3emjef	78	39	a	a	DT
cord-289034-yl3emjef	78	40	central	central	JJ
cord-289034-yl3emjef	78	41	hub	hub	NN
cord-289034-yl3emjef	78	42	that	that	WDT
cord-289034-yl3emjef	78	43	controls	control	VBZ
cord-289034-yl3emjef	78	44	innate	innate	JJ
cord-289034-yl3emjef	78	45	immunity	immunity	NN
cord-289034-yl3emjef	78	46	and	and	CC
cord-289034-yl3emjef	78	47	response	response	NN
cord-289034-yl3emjef	78	48	to	to	IN
cord-289034-yl3emjef	78	49	inflammation	inflammation	NN
cord-289034-yl3emjef	78	50	.	.	.
cord-289034-yl3emjef	79	1	Among	among	IN
cord-289034-yl3emjef	79	2	various	various	JJ
cord-289034-yl3emjef	79	3	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	79	4	conditions	condition	NNS
cord-289034-yl3emjef	79	5	,	,	,
cord-289034-yl3emjef	79	6	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	79	7	are	be	VBP
cord-289034-yl3emjef	79	8	involved	involve	VBN
cord-289034-yl3emjef	79	9	in	in	IN
cord-289034-yl3emjef	79	10	the	the	DT
cord-289034-yl3emjef	79	11	hyper	hyper	JJ
cord-289034-yl3emjef	79	12	-	-	JJ
cord-289034-yl3emjef	79	13	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	79	14	response	response	NN
cord-289034-yl3emjef	79	15	,	,	,
cord-289034-yl3emjef	79	16	also	also	RB
cord-289034-yl3emjef	79	17	reported	report	VBD
cord-289034-yl3emjef	79	18	as	as	IN
cord-289034-yl3emjef	79	19	cytokine	cytokine	NN
cord-289034-yl3emjef	79	20	storm	storm	NN
cord-289034-yl3emjef	79	21	,	,	,
cord-289034-yl3emjef	79	22	caused	cause	VBN
cord-289034-yl3emjef	79	23	by	by	IN
cord-289034-yl3emjef	79	24	the	the	DT
cord-289034-yl3emjef	79	25	SARS	SARS	NNP
cord-289034-yl3emjef	79	26	-	-	HYPH
cord-289034-yl3emjef	79	27	CoV-2	CoV-2	NNP
cord-289034-yl3emjef	79	28	(	(	-LRB-
cord-289034-yl3emjef	79	29	COVID-19	covid-19	VB
cord-289034-yl3emjef	79	30	)	)	-RRB-
cord-289034-yl3emjef	79	31	respiratory	respiratory	NN
cord-289034-yl3emjef	79	32	 	 	_SP
cord-289034-yl3emjef	79	33	Cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	79	34	diseases	disease	NNS
cord-289034-yl3emjef	79	35	are	be	VBP
cord-289034-yl3emjef	79	36	a	a	DT
cord-289034-yl3emjef	79	37	leading	leading	JJ
cord-289034-yl3emjef	79	38	cause	cause	NN
cord-289034-yl3emjef	79	39	of	of	IN
cord-289034-yl3emjef	79	40	death	death	NN
cord-289034-yl3emjef	79	41	worldwide	worldwide	RB
cord-289034-yl3emjef	79	42	.	.	.
cord-289034-yl3emjef	80	1	This	this	DT
cord-289034-yl3emjef	80	2	class	class	NN
cord-289034-yl3emjef	80	3	of	of	IN
cord-289034-yl3emjef	80	4	diseases	disease	NNS
cord-289034-yl3emjef	80	5	comprises	comprise	VBZ
cord-289034-yl3emjef	80	6	several	several	JJ
cord-289034-yl3emjef	80	7	pathologies	pathology	NNS
cord-289034-yl3emjef	80	8	,	,	,
cord-289034-yl3emjef	80	9	including	include	VBG
cord-289034-yl3emjef	80	10	ischemic	ischemic	JJ
cord-289034-yl3emjef	80	11	heart	heart	NN
cord-289034-yl3emjef	80	12	disease	disease	NN
cord-289034-yl3emjef	80	13	,	,	,
cord-289034-yl3emjef	80	14	peripheral	peripheral	JJ
cord-289034-yl3emjef	80	15	vascular	vascular	JJ
cord-289034-yl3emjef	80	16	disease	disease	NN
cord-289034-yl3emjef	80	17	,	,	,
cord-289034-yl3emjef	80	18	cardiac	cardiac	JJ
cord-289034-yl3emjef	80	19	arrest	arrest	NN
cord-289034-yl3emjef	80	20	,	,	,
cord-289034-yl3emjef	80	21	heart	heart	NN
cord-289034-yl3emjef	80	22	failure	failure	NN
cord-289034-yl3emjef	80	23	,	,	,
cord-289034-yl3emjef	80	24	cardiomyopathies	cardiomyopathy	NNS
cord-289034-yl3emjef	80	25	,	,	,
cord-289034-yl3emjef	80	26	hypertension	hypertension	NN
cord-289034-yl3emjef	80	27	,	,	,
cord-289034-yl3emjef	80	28	atherosclerosis	atherosclerosis	NN
cord-289034-yl3emjef	80	29	,	,	,
cord-289034-yl3emjef	80	30	and	and	CC
cord-289034-yl3emjef	80	31	arrhythmia	arrhythmia	NN
cord-289034-yl3emjef	80	32	.	.	.
cord-289034-yl3emjef	81	1	Mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	81	2	have	have	VBP
cord-289034-yl3emjef	81	3	been	be	VBN
cord-289034-yl3emjef	81	4	involved	involve	VBN
cord-289034-yl3emjef	81	5	at	at	IN
cord-289034-yl3emjef	81	6	various	various	JJ
cord-289034-yl3emjef	81	7	degrees	degree	NNS
cord-289034-yl3emjef	81	8	in	in	IN
cord-289034-yl3emjef	81	9	the	the	DT
cord-289034-yl3emjef	81	10	pathological	pathological	JJ
cord-289034-yl3emjef	81	11	aspects	aspect	NNS
cord-289034-yl3emjef	81	12	of	of	IN
cord-289034-yl3emjef	81	13	these	these	DT
cord-289034-yl3emjef	81	14	diseases	disease	NNS
cord-289034-yl3emjef	81	15	.	.	.
cord-289034-yl3emjef	82	1	Notably	notably	RB
cord-289034-yl3emjef	82	2	,	,	,
cord-289034-yl3emjef	82	3	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	82	4	dysfunction	dysfunction	NN
cord-289034-yl3emjef	82	5	of	of	IN
cord-289034-yl3emjef	82	6	muscle	muscle	NN
cord-289034-yl3emjef	82	7	cells	cell	NNS
cord-289034-yl3emjef	82	8	represents	represent	VBZ
cord-289034-yl3emjef	82	9	a	a	DT
cord-289034-yl3emjef	82	10	key	key	JJ
cord-289034-yl3emjef	82	11	event	event	NN
cord-289034-yl3emjef	82	12	in	in	IN
cord-289034-yl3emjef	82	13	the	the	DT
cord-289034-yl3emjef	82	14	prognosis	prognosis	NN
cord-289034-yl3emjef	82	15	of	of	IN
cord-289034-yl3emjef	82	16	peripheral	peripheral	JJ
cord-289034-yl3emjef	82	17	arterial	arterial	JJ
cord-289034-yl3emjef	82	18	disease	disease	NN
cord-289034-yl3emjef	82	19	.	.	.
cord-289034-yl3emjef	83	1	Reduced	reduce	VBN
cord-289034-yl3emjef	83	2	OXPHOS	OXPHOS	NNP
cord-289034-yl3emjef	83	3	activity	activity	NN
cord-289034-yl3emjef	83	4	due	due	IN
cord-289034-yl3emjef	83	5	to	to	IN
cord-289034-yl3emjef	83	6	ETC	etc	FW
cord-289034-yl3emjef	83	7	impairment	impairment	NN
cord-289034-yl3emjef	83	8	increases	increase	VBZ
cord-289034-yl3emjef	83	9	ROS	ROS	NNP
cord-289034-yl3emjef	83	10	levels	level	NNS
cord-289034-yl3emjef	83	11	and	and	CC
cord-289034-yl3emjef	84	1	Ca	ca	NN
cord-289034-yl3emjef	84	2	2	2	CD
cord-289034-yl3emjef	84	3	+	+	CC
cord-289034-yl3emjef	84	4	release	release	NN
cord-289034-yl3emjef	84	5	from	from	IN
cord-289034-yl3emjef	84	6	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	84	7	,	,	.
cord-289034-yl3emjef	85	1	causing	cause	VBG
cord-289034-yl3emjef	85	2	apoptosis	apoptosis	NN
cord-289034-yl3emjef	85	3	[	[	-LRB-
cord-289034-yl3emjef	85	4	24	24	CD
cord-289034-yl3emjef	85	5	]	]	-RRB-
cord-289034-yl3emjef	85	6	.	.	.
cord-289034-yl3emjef	86	1	However	however	RB
cord-289034-yl3emjef	86	2	,	,	,
cord-289034-yl3emjef	86	3	if	if	IN
cord-289034-yl3emjef	86	4	ROS	ROS	NNP
cord-289034-yl3emjef	86	5	levels	level	NNS
cord-289034-yl3emjef	86	6	remain	remain	VBP
cord-289034-yl3emjef	86	7	below	below	IN
cord-289034-yl3emjef	86	8	a	a	DT
cord-289034-yl3emjef	86	9	threshold	threshold	NN
cord-289034-yl3emjef	86	10	,	,	,
cord-289034-yl3emjef	86	11	the	the	DT
cord-289034-yl3emjef	86	12	cells	cell	NNS
cord-289034-yl3emjef	86	13	activate	activate	VBP
cord-289034-yl3emjef	86	14	a	a	DT
cord-289034-yl3emjef	86	15	defense	defense	NN
cord-289034-yl3emjef	86	16	program	program	NN
cord-289034-yl3emjef	86	17	involving	involve	VBG
cord-289034-yl3emjef	86	18	production	production	NN
cord-289034-yl3emjef	86	19	of	of	IN
cord-289034-yl3emjef	86	20	antioxidants	antioxidant	NNS
cord-289034-yl3emjef	86	21	and	and	CC
cord-289034-yl3emjef	86	22	increased	increase	VBN
cord-289034-yl3emjef	86	23	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	86	24	biogenesis	biogenesis	NN
cord-289034-yl3emjef	86	25	.	.	.
cord-289034-yl3emjef	87	1	These	these	DT
cord-289034-yl3emjef	87	2	mechanisms	mechanism	NNS
cord-289034-yl3emjef	87	3	,	,	,
cord-289034-yl3emjef	87	4	known	know	VBN
cord-289034-yl3emjef	87	5	as	as	IN
cord-289034-yl3emjef	87	6	mitohormesis	mitohormesis	NN
cord-289034-yl3emjef	87	7	,	,	,
cord-289034-yl3emjef	87	8	can	can	MD
cord-289034-yl3emjef	87	9	limit	limit	VB
cord-289034-yl3emjef	87	10	the	the	DT
cord-289034-yl3emjef	87	11	damage	damage	NN
cord-289034-yl3emjef	87	12	caused	cause	VBN
cord-289034-yl3emjef	87	13	by	by	IN
cord-289034-yl3emjef	87	14	repeated	repeat	VBN
cord-289034-yl3emjef	87	15	cycles	cycle	NNS
cord-289034-yl3emjef	87	16	of	of	IN
cord-289034-yl3emjef	87	17	ischemia	ischemia	NN
cord-289034-yl3emjef	87	18	-	-	HYPH
cord-289034-yl3emjef	87	19	reperfusion	reperfusion	NN
cord-289034-yl3emjef	87	20	in	in	IN
cord-289034-yl3emjef	87	21	peripheral	peripheral	JJ
cord-289034-yl3emjef	87	22	arterial	arterial	JJ
cord-289034-yl3emjef	87	23	disease	disease	NN
cord-289034-yl3emjef	87	24	[	[	-LRB-
cord-289034-yl3emjef	87	25	24	24	CD
cord-289034-yl3emjef	87	26	]	]	-RRB-
cord-289034-yl3emjef	87	27	.	.	.
cord-289034-yl3emjef	88	1	Pharmacological	pharmacological	JJ
cord-289034-yl3emjef	88	2	treatments	treatment	NNS
cord-289034-yl3emjef	88	3	that	that	WDT
cord-289034-yl3emjef	88	4	can	can	MD
cord-289034-yl3emjef	88	5	improve	improve	VB
cord-289034-yl3emjef	88	6	mitohormesis	mitohormesis	NN
cord-289034-yl3emjef	88	7	might	may	MD
cord-289034-yl3emjef	88	8	be	be	VB
cord-289034-yl3emjef	88	9	a	a	DT
cord-289034-yl3emjef	88	10	promising	promising	JJ
cord-289034-yl3emjef	88	11	therapeutic	therapeutic	JJ
cord-289034-yl3emjef	88	12	approach	approach	NN
cord-289034-yl3emjef	88	13	for	for	IN
cord-289034-yl3emjef	88	14	peripheral	peripheral	JJ
cord-289034-yl3emjef	88	15	arterial	arterial	JJ
cord-289034-yl3emjef	88	16	disease	disease	NN
cord-289034-yl3emjef	88	17	and	and	CC
cord-289034-yl3emjef	88	18	other	other	JJ
cord-289034-yl3emjef	88	19	cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	88	20	diseases	disease	NNS
cord-289034-yl3emjef	88	21	.	.	.
cord-289034-yl3emjef	89	1	Disruption	disruption	NN
cord-289034-yl3emjef	89	2	of	of	IN
cord-289034-yl3emjef	89	3	mitophagy	mitophagy	NNP
cord-289034-yl3emjef	89	4	also	also	RB
cord-289034-yl3emjef	89	5	exacerbates	exacerbate	VBZ
cord-289034-yl3emjef	89	6	the	the	DT
cord-289034-yl3emjef	89	7	development	development	NN
cord-289034-yl3emjef	89	8	of	of	IN
cord-289034-yl3emjef	89	9	cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	89	10	diseases	disease	NNS
cord-289034-yl3emjef	89	11	[	[	-LRB-
cord-289034-yl3emjef	89	12	7	7	CD
cord-289034-yl3emjef	89	13	]	]	-RRB-
cord-289034-yl3emjef	89	14	.	.	.
cord-289034-yl3emjef	90	1	Growing	grow	VBG
cord-289034-yl3emjef	90	2	evidence	evidence	NN
cord-289034-yl3emjef	90	3	indicates	indicate	VBZ
cord-289034-yl3emjef	90	4	that	that	IN
cord-289034-yl3emjef	90	5	the	the	DT
cord-289034-yl3emjef	90	6	pharmacological	pharmacological	JJ
cord-289034-yl3emjef	90	7	targeting	targeting	NN
cord-289034-yl3emjef	90	8	of	of	IN
cord-289034-yl3emjef	90	9	the	the	DT
cord-289034-yl3emjef	90	10	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	90	11	with	with	IN
cord-289034-yl3emjef	90	12	drugs	drug	NNS
cord-289034-yl3emjef	90	13	/	/	SYM
cord-289034-yl3emjef	90	14	natural	natural	JJ
cord-289034-yl3emjef	90	15	compounds	compound	NNS
cord-289034-yl3emjef	90	16	able	able	JJ
cord-289034-yl3emjef	90	17	to	to	TO
cord-289034-yl3emjef	90	18	modulate	modulate	VB
cord-289034-yl3emjef	90	19	mitophagy	mitophagy	NN
cord-289034-yl3emjef	90	20	can	can	MD
cord-289034-yl3emjef	90	21	ameliorate	ameliorate	VB
cord-289034-yl3emjef	90	22	cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	90	23	disorders	disorder	NNS
cord-289034-yl3emjef	90	24	in	in	IN
cord-289034-yl3emjef	90	25	patients	patient	NNS
cord-289034-yl3emjef	90	26	and	and	CC
cord-289034-yl3emjef	90	27	be	be	VB
cord-289034-yl3emjef	90	28	cardioprotective	cardioprotective	JJ
cord-289034-yl3emjef	90	29	[	[	-LRB-
cord-289034-yl3emjef	90	30	7	7	CD
cord-289034-yl3emjef	90	31	,	,	,
cord-289034-yl3emjef	90	32	25	25	CD
cord-289034-yl3emjef	90	33	]	]	-RRB-
cord-289034-yl3emjef	90	34	.	.	.
cord-289034-yl3emjef	91	1	Future	future	JJ
cord-289034-yl3emjef	91	2	studies	study	NNS
cord-289034-yl3emjef	91	3	that	that	WDT
cord-289034-yl3emjef	91	4	aim	aim	VBP
cord-289034-yl3emjef	91	5	at	at	IN
cord-289034-yl3emjef	91	6	a	a	DT
cord-289034-yl3emjef	91	7	better	well	JJR
cord-289034-yl3emjef	91	8	understanding	understanding	NN
cord-289034-yl3emjef	91	9	the	the	DT
cord-289034-yl3emjef	91	10	pathogenesis	pathogenesis	NN
cord-289034-yl3emjef	91	11	of	of	IN
cord-289034-yl3emjef	91	12	some	some	DT
cord-289034-yl3emjef	91	13	cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	91	14	diseases	disease	NNS
cord-289034-yl3emjef	91	15	are	be	VBP
cord-289034-yl3emjef	91	16	crucial	crucial	JJ
cord-289034-yl3emjef	91	17	to	to	TO
cord-289034-yl3emjef	91	18	develop	develop	VB
cord-289034-yl3emjef	91	19	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	91	20	-	-	HYPH
cord-289034-yl3emjef	91	21	targeting	target	VBG
cord-289034-yl3emjef	91	22	drugs	drug	NNS
cord-289034-yl3emjef	91	23	in	in	IN
cord-289034-yl3emjef	91	24	the	the	DT
cord-289034-yl3emjef	91	25	clinic	clinic	NN
cord-289034-yl3emjef	91	26	.	.	.
cord-289034-yl3emjef	92	1	Inflammation	inflammation	NN
cord-289034-yl3emjef	92	2	is	be	VBZ
cord-289034-yl3emjef	92	3	a	a	DT
cord-289034-yl3emjef	92	4	complex	complex	JJ
cord-289034-yl3emjef	92	5	,	,	,
cord-289034-yl3emjef	92	6	protective	protective	JJ
cord-289034-yl3emjef	92	7	body	body	NN
cord-289034-yl3emjef	92	8	response	response	NN
cord-289034-yl3emjef	92	9	to	to	IN
cord-289034-yl3emjef	92	10	infections	infection	NNS
cord-289034-yl3emjef	92	11	and	and	CC
cord-289034-yl3emjef	92	12	tissue	tissue	NN
cord-289034-yl3emjef	92	13	damage	damage	NN
cord-289034-yl3emjef	92	14	.	.	.
cord-289034-yl3emjef	93	1	The	the	DT
cord-289034-yl3emjef	93	2	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	93	3	response	response	NN
cord-289034-yl3emjef	93	4	signals	signal	VBZ
cord-289034-yl3emjef	93	5	the	the	DT
cord-289034-yl3emjef	93	6	immune	immune	JJ
cord-289034-yl3emjef	93	7	system	system	NN
cord-289034-yl3emjef	93	8	to	to	TO
cord-289034-yl3emjef	93	9	repair	repair	VB
cord-289034-yl3emjef	93	10	damaged	damage	VBN
cord-289034-yl3emjef	93	11	tissue	tissue	NN
cord-289034-yl3emjef	93	12	and	and	CC
cord-289034-yl3emjef	93	13	defend	defend	VB
cord-289034-yl3emjef	93	14	against	against	IN
cord-289034-yl3emjef	93	15	pathogens	pathogen	NNS
cord-289034-yl3emjef	93	16	(	(	-LRB-
cord-289034-yl3emjef	93	17	viruses	virus	NNS
cord-289034-yl3emjef	93	18	,	,	,
cord-289034-yl3emjef	93	19	bacteria	bacteria	NNS
cord-289034-yl3emjef	93	20	,	,	,
cord-289034-yl3emjef	93	21	etc	etc	FW
cord-289034-yl3emjef	93	22	.	.	.
cord-289034-yl3emjef	93	23	)	)	-RRB-
cord-289034-yl3emjef	93	24	or	or	CC
cord-289034-yl3emjef	93	25	other	other	JJ
cord-289034-yl3emjef	93	26	harmful	harmful	JJ
cord-289034-yl3emjef	93	27	stimuli	stimulus	NNS
cord-289034-yl3emjef	93	28	through	through	IN
cord-289034-yl3emjef	93	29	secretion	secretion	NN
cord-289034-yl3emjef	93	30	of	of	IN
cord-289034-yl3emjef	93	31	specific	specific	JJ
cord-289034-yl3emjef	93	32	mediators	mediator	NNS
cord-289034-yl3emjef	93	33	.	.	.
cord-289034-yl3emjef	94	1	However	however	RB
cord-289034-yl3emjef	94	2	,	,	,
cord-289034-yl3emjef	94	3	when	when	WRB
cord-289034-yl3emjef	94	4	inflammation	inflammation	NN
cord-289034-yl3emjef	94	5	persists	persist	VBZ
cord-289034-yl3emjef	94	6	,	,	,
cord-289034-yl3emjef	94	7	it	-PRON-	PRP
cord-289034-yl3emjef	94	8	may	may	MD
cord-289034-yl3emjef	94	9	drive	drive	VB
cord-289034-yl3emjef	94	10	various	various	JJ
cord-289034-yl3emjef	94	11	diseases	disease	NNS
cord-289034-yl3emjef	94	12	and	and	CC
cord-289034-yl3emjef	94	13	tissue	tissue	NN
cord-289034-yl3emjef	94	14	damage	damage	NN
cord-289034-yl3emjef	94	15	.	.	.
cord-289034-yl3emjef	95	1	Mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	95	2	-	-	HYPH
cord-289034-yl3emjef	95	3	derived	derive	VBN
cord-289034-yl3emjef	95	4	ROS	ROS	NNP
cord-289034-yl3emjef	95	5	play	play	VB
cord-289034-yl3emjef	95	6	a	a	DT
cord-289034-yl3emjef	95	7	key	key	JJ
cord-289034-yl3emjef	95	8	role	role	NN
cord-289034-yl3emjef	95	9	in	in	IN
cord-289034-yl3emjef	95	10	the	the	DT
cord-289034-yl3emjef	95	11	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	95	12	response	response	NN
cord-289034-yl3emjef	95	13	.	.	.
cord-289034-yl3emjef	96	1	Notably	notably	RB
cord-289034-yl3emjef	96	2	,	,	,
cord-289034-yl3emjef	96	3	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	96	4	are	be	VBP
cord-289034-yl3emjef	96	5	considered	consider	VBN
cord-289034-yl3emjef	96	6	the	the	DT
cord-289034-yl3emjef	96	7	main	main	JJ
cord-289034-yl3emjef	96	8	drivers	driver	NNS
cord-289034-yl3emjef	96	9	of	of	IN
cord-289034-yl3emjef	96	10	the	the	DT
cord-289034-yl3emjef	96	11	NLRP3	nlrp3	NN
cord-289034-yl3emjef	96	12	(	(	-LRB-
cord-289034-yl3emjef	96	13	NOD-	NOD-	NNP
cord-289034-yl3emjef	96	14	,	,	,
cord-289034-yl3emjef	96	15	LRR	LRR	NNP
cord-289034-yl3emjef	96	16	-	-	HYPH
cord-289034-yl3emjef	96	17	and	and	CC
cord-289034-yl3emjef	96	18	pyrin	pyrin	NNP
cord-289034-yl3emjef	96	19	domain	domain	NN
cord-289034-yl3emjef	96	20	-	-	:
cord-289034-yl3emjef	96	21	containing	contain	VBG
cord-289034-yl3emjef	96	22	3	3	CD
cord-289034-yl3emjef	96	23	)	)	-RRB-
cord-289034-yl3emjef	96	24	inflammasome	inflammasome	NNP
cord-289034-yl3emjef	96	25	[	[	-LRB-
cord-289034-yl3emjef	96	26	26	26	CD
cord-289034-yl3emjef	96	27	]	]	-RRB-
cord-289034-yl3emjef	96	28	[	[	-LRB-
cord-289034-yl3emjef	96	29	27	27	CD
cord-289034-yl3emjef	96	30	]	]	-RRB-
cord-289034-yl3emjef	96	31	[	[	-LRB-
cord-289034-yl3emjef	96	32	28	28	CD
cord-289034-yl3emjef	96	33	]	]	-RRB-
cord-289034-yl3emjef	96	34	[	[	-LRB-
cord-289034-yl3emjef	96	35	29	29	CD
cord-289034-yl3emjef	96	36	]	]	-RRB-
cord-289034-yl3emjef	96	37	,	,	,
cord-289034-yl3emjef	96	38	representing	represent	VBG
cord-289034-yl3emjef	96	39	a	a	DT
cord-289034-yl3emjef	96	40	central	central	JJ
cord-289034-yl3emjef	96	41	hub	hub	NN
cord-289034-yl3emjef	96	42	that	that	WDT
cord-289034-yl3emjef	96	43	controls	control	VBZ
cord-289034-yl3emjef	96	44	innate	innate	JJ
cord-289034-yl3emjef	96	45	immunity	immunity	NN
cord-289034-yl3emjef	96	46	and	and	CC
cord-289034-yl3emjef	96	47	response	response	NN
cord-289034-yl3emjef	96	48	to	to	IN
cord-289034-yl3emjef	96	49	inflammation	inflammation	NN
cord-289034-yl3emjef	96	50	.	.	.
cord-289034-yl3emjef	97	1	Among	among	IN
cord-289034-yl3emjef	97	2	various	various	JJ
cord-289034-yl3emjef	97	3	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	97	4	conditions	condition	NNS
cord-289034-yl3emjef	97	5	,	,	,
cord-289034-yl3emjef	97	6	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	97	7	are	be	VBP
cord-289034-yl3emjef	97	8	involved	involve	VBN
cord-289034-yl3emjef	97	9	in	in	IN
cord-289034-yl3emjef	97	10	the	the	DT
cord-289034-yl3emjef	97	11	hyper	hyper	JJ
cord-289034-yl3emjef	97	12	-	-	JJ
cord-289034-yl3emjef	97	13	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	97	14	response	response	NN
cord-289034-yl3emjef	97	15	,	,	,
cord-289034-yl3emjef	97	16	also	also	RB
cord-289034-yl3emjef	97	17	reported	report	VBD
cord-289034-yl3emjef	97	18	as	as	IN
cord-289034-yl3emjef	97	19	cytokine	cytokine	NN
cord-289034-yl3emjef	97	20	storm	storm	NN
cord-289034-yl3emjef	97	21	,	,	,
cord-289034-yl3emjef	97	22	caused	cause	VBN
cord-289034-yl3emjef	97	23	by	by	IN
cord-289034-yl3emjef	97	24	the	the	DT
cord-289034-yl3emjef	97	25	SARS	SARS	NNP
cord-289034-yl3emjef	97	26	-	-	HYPH
cord-289034-yl3emjef	97	27	CoV-2	CoV-2	NNP
cord-289034-yl3emjef	97	28	(	(	-LRB-
cord-289034-yl3emjef	97	29	COVID-19	covid-19	VB
cord-289034-yl3emjef	97	30	)	)	-RRB-
cord-289034-yl3emjef	97	31	respiratory	respiratory	JJ
cord-289034-yl3emjef	97	32	infection	infection	NN
cord-289034-yl3emjef	97	33	(	(	-LRB-
cord-289034-yl3emjef	97	34	[	[	-LRB-
cord-289034-yl3emjef	97	35	30	30	CD
cord-289034-yl3emjef	97	36	]	]	-RRB-
cord-289034-yl3emjef	97	37	and	and	CC
cord-289034-yl3emjef	97	38	references	reference	NNS
cord-289034-yl3emjef	97	39	therein	therein	RB
cord-289034-yl3emjef	97	40	)	)	-RRB-
cord-289034-yl3emjef	97	41	.	.	.
cord-289034-yl3emjef	98	1	When	when	WRB
cord-289034-yl3emjef	98	2	macrophages	macrophage	NNS
cord-289034-yl3emjef	98	3	and	and	CC
cord-289034-yl3emjef	98	4	other	other	JJ
cord-289034-yl3emjef	98	5	immune	immune	JJ
cord-289034-yl3emjef	98	6	cells	cell	NNS
cord-289034-yl3emjef	98	7	detect	detect	VBP
cord-289034-yl3emjef	98	8	viruses	virus	NNS
cord-289034-yl3emjef	98	9	,	,	,
cord-289034-yl3emjef	98	10	they	-PRON-	PRP
cord-289034-yl3emjef	98	11	start	start	VBP
cord-289034-yl3emjef	98	12	secreting	secrete	VBG
cord-289034-yl3emjef	98	13	cytokines	cytokine	NNS
cord-289034-yl3emjef	98	14	and	and	CC
cord-289034-yl3emjef	98	15	chemokines	chemokine	NNS
cord-289034-yl3emjef	98	16	to	to	TO
cord-289034-yl3emjef	98	17	communicate	communicate	VB
cord-289034-yl3emjef	98	18	with	with	IN
cord-289034-yl3emjef	98	19	other	other	JJ
cord-289034-yl3emjef	98	20	immune	immune	JJ
cord-289034-yl3emjef	98	21	cells	cell	NNS
cord-289034-yl3emjef	98	22	[	[	-LRB-
cord-289034-yl3emjef	98	23	31	31	CD
cord-289034-yl3emjef	98	24	]	]	-RRB-
cord-289034-yl3emjef	98	25	.	.	.
cord-289034-yl3emjef	99	1	Strikingly	strikingly	RB
cord-289034-yl3emjef	99	2	,	,	,
cord-289034-yl3emjef	99	3	Wuhan	Wuhan	NNP
cord-289034-yl3emjef	99	4	's	's	POS
cord-289034-yl3emjef	99	5	Covid-19	covid-19	NN
cord-289034-yl3emjef	99	6	patients	patient	NNS
cord-289034-yl3emjef	99	7	with	with	IN
cord-289034-yl3emjef	99	8	severe	severe	JJ
cord-289034-yl3emjef	99	9	clinical	clinical	JJ
cord-289034-yl3emjef	99	10	symptoms	symptom	NNS
cord-289034-yl3emjef	99	11	requiring	require	VBG
cord-289034-yl3emjef	99	12	ICU	ICU	NNP
cord-289034-yl3emjef	99	13	admission	admission	NN
cord-289034-yl3emjef	99	14	displayed	display	VBD
cord-289034-yl3emjef	99	15	higher	high	JJR
cord-289034-yl3emjef	99	16	levels	level	NNS
cord-289034-yl3emjef	99	17	of	of	IN
cord-289034-yl3emjef	99	18	the	the	DT
cord-289034-yl3emjef	99	19	cytokines	cytokine	NNS
cord-289034-yl3emjef	99	20	/	/	SYM
cord-289034-yl3emjef	99	21	chemokines	chemokine	NNS
cord-289034-yl3emjef	99	22	CCL2	CCL2	NNP
cord-289034-yl3emjef	99	23	,	,	,
cord-289034-yl3emjef	99	24	TNF	TNF	NNP
cord-289034-yl3emjef	99	25	-	-	HYPH
cord-289034-yl3emjef	99	26	α	α	NNP
cord-289034-yl3emjef	99	27	and	and	CC
cord-289034-yl3emjef	99	28	CXCL10	CXCL10	NNP
cord-289034-yl3emjef	99	29	compared	compare	VBN
cord-289034-yl3emjef	99	30	to	to	IN
cord-289034-yl3emjef	99	31	individuals	individual	NNS
cord-289034-yl3emjef	99	32	with	with	IN
cord-289034-yl3emjef	99	33	less	less	RBR
cord-289034-yl3emjef	99	34	severe	severe	JJ
cord-289034-yl3emjef	99	35	symptoms	symptom	NNS
cord-289034-yl3emjef	99	36	[	[	-LRB-
cord-289034-yl3emjef	99	37	32	32	CD
cord-289034-yl3emjef	99	38	]	]	-RRB-
cord-289034-yl3emjef	99	39	.	.	.
cord-289034-yl3emjef	100	1	The	the	DT
cord-289034-yl3emjef	100	2	release	release	NN
cord-289034-yl3emjef	100	3	of	of	IN
cord-289034-yl3emjef	100	4	large	large	JJ
cord-289034-yl3emjef	100	5	quantities	quantity	NNS
cord-289034-yl3emjef	100	6	of	of	IN
cord-289034-yl3emjef	100	7	pro	pro	JJ
cord-289034-yl3emjef	100	8	-	-	JJ
cord-289034-yl3emjef	100	9	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	100	10	cytokines	cytokine	NNS
cord-289034-yl3emjef	100	11	and	and	CC
cord-289034-yl3emjef	100	12	chemokines	chemokine	NNS
cord-289034-yl3emjef	100	13	by	by	IN
cord-289034-yl3emjef	100	14	overdriven	overdriven	JJ
cord-289034-yl3emjef	100	15	immune	immune	JJ
cord-289034-yl3emjef	100	16	effector	effector	NN
cord-289034-yl3emjef	100	17	cells	cell	NNS
cord-289034-yl3emjef	100	18	sustains	sustain	VBZ
cord-289034-yl3emjef	100	19	an	an	DT
cord-289034-yl3emjef	100	20	aberrant	aberrant	JJ
cord-289034-yl3emjef	100	21	systemic	systemic	JJ
cord-289034-yl3emjef	100	22	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	100	23	response	response	NN
cord-289034-yl3emjef	100	24	that	that	WDT
cord-289034-yl3emjef	100	25	results	result	VBZ
cord-289034-yl3emjef	100	26	in	in	IN
cord-289034-yl3emjef	100	27	the	the	DT
cord-289034-yl3emjef	100	28	immune	immune	JJ
cord-289034-yl3emjef	100	29	system	system	NN
cord-289034-yl3emjef	100	30	attacking	attack	VBG
cord-289034-yl3emjef	100	31	the	the	DT
cord-289034-yl3emjef	100	32	body	body	NN
cord-289034-yl3emjef	100	33	,	,	,
cord-289034-yl3emjef	100	34	which	which	WDT
cord-289034-yl3emjef	100	35	in	in	IN
cord-289034-yl3emjef	100	36	turn	turn	NN
cord-289034-yl3emjef	100	37	causes	cause	VBZ
cord-289034-yl3emjef	100	38	the	the	DT
cord-289034-yl3emjef	100	39	acute	acute	JJ
cord-289034-yl3emjef	100	40	respiratory	respiratory	JJ
cord-289034-yl3emjef	100	41	distress	distress	NN
cord-289034-yl3emjef	100	42	syndrome	syndrome	NN
cord-289034-yl3emjef	100	43	[	[	-LRB-
cord-289034-yl3emjef	100	44	33	33	CD
cord-289034-yl3emjef	100	45	]	]	-RRB-
cord-289034-yl3emjef	100	46	.	.	.
cord-289034-yl3emjef	101	1	Immune	immune	JJ
cord-289034-yl3emjef	101	2	cells	cell	NNS
cord-289034-yl3emjef	101	3	under	under	IN
cord-289034-yl3emjef	101	4	a	a	DT
cord-289034-yl3emjef	101	5	hyper	hyper	JJ
cord-289034-yl3emjef	101	6	-	-	JJ
cord-289034-yl3emjef	101	7	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	101	8	state	state	NN
cord-289034-yl3emjef	101	9	metabolically	metabolically	RB
cord-289034-yl3emjef	101	10	adapt	adapt	VBP
cord-289034-yl3emjef	101	11	to	to	IN
cord-289034-yl3emjef	101	12	this	this	DT
cord-289034-yl3emjef	101	13	stress	stress	NN
cord-289034-yl3emjef	101	14	condition	condition	NN
cord-289034-yl3emjef	101	15	by	by	IN
cord-289034-yl3emjef	101	16	favoring	favor	VBG
cord-289034-yl3emjef	101	17	aerobic	aerobic	JJ
cord-289034-yl3emjef	101	18	glycolysis	glycolysis	NN
cord-289034-yl3emjef	101	19	over	over	IN
cord-289034-yl3emjef	101	20	OXPHOS	OXPHOS	NNP
cord-289034-yl3emjef	101	21	for	for	IN
cord-289034-yl3emjef	101	22	energy	energy	NN
cord-289034-yl3emjef	101	23	production	production	NN
cord-289034-yl3emjef	101	24	.	.	.
cord-289034-yl3emjef	102	1	This	this	DT
cord-289034-yl3emjef	102	2	metabolic	metabolic	JJ
cord-289034-yl3emjef	102	3	rewiring	rewiring	NN
cord-289034-yl3emjef	102	4	allows	allow	VBZ
cord-289034-yl3emjef	102	5	macrophages	macrophage	NNS
cord-289034-yl3emjef	102	6	to	to	TO
cord-289034-yl3emjef	102	7	become	become	VB
cord-289034-yl3emjef	102	8	more	more	RBR
cord-289034-yl3emjef	102	9	phagocytic	phagocytic	JJ
cord-289034-yl3emjef	102	10	and	and	CC
cord-289034-yl3emjef	102	11	favors	favor	VBZ
cord-289034-yl3emjef	102	12	anabolic	anabolic	JJ
cord-289034-yl3emjef	102	13	reactions	reaction	NNS
cord-289034-yl3emjef	102	14	for	for	IN
cord-289034-yl3emjef	102	15	the	the	DT
cord-289034-yl3emjef	102	16	synthesis	synthesis	NN
cord-289034-yl3emjef	102	17	and	and	CC
cord-289034-yl3emjef	102	18	secretion	secretion	NN
cord-289034-yl3emjef	102	19	of	of	IN
cord-289034-yl3emjef	102	20	cytokines	cytokine	NNS
cord-289034-yl3emjef	102	21	and	and	CC
cord-289034-yl3emjef	102	22	chemokines	chemokine	NNS
cord-289034-yl3emjef	102	23	in	in	IN
cord-289034-yl3emjef	102	24	a	a	DT
cord-289034-yl3emjef	102	25	vicious	vicious	JJ
cord-289034-yl3emjef	102	26	cycle	cycle	NN
cord-289034-yl3emjef	102	27	(	(	-LRB-
cord-289034-yl3emjef	102	28	[	[	-LRB-
cord-289034-yl3emjef	102	29	30	30	CD
cord-289034-yl3emjef	102	30	]	]	-RRB-
cord-289034-yl3emjef	102	31	and	and	CC
cord-289034-yl3emjef	102	32	references	reference	NNS
cord-289034-yl3emjef	102	33	therein	therein	RB
cord-289034-yl3emjef	102	34	)	)	-RRB-
cord-289034-yl3emjef	102	35	.	.	.
cord-289034-yl3emjef	103	1	Side	side	NN
cord-289034-yl3emjef	103	2	by	by	IN
cord-289034-yl3emjef	103	3	side	side	NN
cord-289034-yl3emjef	103	4	,	,	,
cord-289034-yl3emjef	103	5	many	many	JJ
cord-289034-yl3emjef	103	6	biosynthetic	biosynthetic	JJ
cord-289034-yl3emjef	103	7	reactions	reaction	NNS
cord-289034-yl3emjef	103	8	occurring	occur	VBG
cord-289034-yl3emjef	103	9	in	in	IN
cord-289034-yl3emjef	103	10	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	103	11	of	of	IN
cord-289034-yl3emjef	103	12	hyper	hyper	RB
cord-289034-yl3emjef	103	13	-	-	HYPH
cord-289034-yl3emjef	103	14	activated	activate	VBN
cord-289034-yl3emjef	103	15	macrophages	macrophage	NNS
cord-289034-yl3emjef	103	16	are	be	VBP
cord-289034-yl3emjef	103	17	inhibited	inhibit	VBN
cord-289034-yl3emjef	103	18	as	as	IN
cord-289034-yl3emjef	103	19	a	a	DT
cord-289034-yl3emjef	103	20	consequence	consequence	NN
cord-289034-yl3emjef	103	21	of	of	IN
cord-289034-yl3emjef	103	22	OXPHOS	OXPHOS	NNP
cord-289034-yl3emjef	103	23	and	and	CC
cord-289034-yl3emjef	103	24	TCA	TCA	NNP
cord-289034-yl3emjef	103	25	cycle	cycle	NN
cord-289034-yl3emjef	103	26	inhibition	inhibition	NN
cord-289034-yl3emjef	103	27	.	.	.
cord-289034-yl3emjef	104	1	Melatonin	melatonin	NN
cord-289034-yl3emjef	104	2	's	's	POS
cord-289034-yl3emjef	104	3	synthesis	synthesis	NN
cord-289034-yl3emjef	104	4	is	be	VBZ
cord-289034-yl3emjef	104	5	among	among	IN
cord-289034-yl3emjef	104	6	these	these	DT
cord-289034-yl3emjef	104	7	reactions	reaction	NNS
cord-289034-yl3emjef	104	8	:	:	:
cord-289034-yl3emjef	104	9	acetyl	acetyl	NN
cord-289034-yl3emjef	104	10	-	-	HYPH
cord-289034-yl3emjef	104	11	CoA	CoA	NNP
cord-289034-yl3emjef	104	12	,	,	,
cord-289034-yl3emjef	104	13	a	a	DT
cord-289034-yl3emjef	104	14	cofactor	cofactor	NN
cord-289034-yl3emjef	104	15	in	in	IN
cord-289034-yl3emjef	104	16	the	the	DT
cord-289034-yl3emjef	104	17	rate	rate	NN
cord-289034-yl3emjef	104	18	-	-	HYPH
cord-289034-yl3emjef	104	19	limiting	limit	VBG
cord-289034-yl3emjef	104	20	reaction	reaction	NN
cord-289034-yl3emjef	104	21	for	for	IN
cord-289034-yl3emjef	104	22	melatonin	melatonin	NN
cord-289034-yl3emjef	104	23	synthesis	synthesis	NN
cord-289034-yl3emjef	104	24	,	,	,
cord-289034-yl3emjef	104	25	lacks	lack	VBZ
cord-289034-yl3emjef	104	26	due	due	IN
cord-289034-yl3emjef	104	27	to	to	IN
cord-289034-yl3emjef	104	28	the	the	DT
cord-289034-yl3emjef	104	29	TCA	TCA	NNP
cord-289034-yl3emjef	104	30	cycle	cycle	NN
cord-289034-yl3emjef	104	31	inhibition	inhibition	NN
cord-289034-yl3emjef	104	32	[	[	-LRB-
cord-289034-yl3emjef	104	33	30	30	CD
cord-289034-yl3emjef	104	34	]	]	-RRB-
cord-289034-yl3emjef	104	35	.	.	.
cord-289034-yl3emjef	105	1	Thus	thus	RB
cord-289034-yl3emjef	105	2	,	,	,
cord-289034-yl3emjef	105	3	melatonin	melatonin	NN
cord-289034-yl3emjef	105	4	can	can	MD
cord-289034-yl3emjef	105	5	not	not	RB
cord-289034-yl3emjef	105	6	be	be	VB
cord-289034-yl3emjef	105	7	synthetized	synthetize	VBN
cord-289034-yl3emjef	105	8	.	.	.
cord-289034-yl3emjef	106	1	Notably	notably	RB
cord-289034-yl3emjef	106	2	,	,	,
cord-289034-yl3emjef	106	3	melatonin	melatonin	NN
cord-289034-yl3emjef	106	4	is	be	VBZ
cord-289034-yl3emjef	106	5	a	a	DT
cord-289034-yl3emjef	106	6	potent	potent	JJ
cord-289034-yl3emjef	106	7	anti	anti	JJ
cord-289034-yl3emjef	106	8	-	-	JJ
cord-289034-yl3emjef	106	9	inflammatory	inflammatory	JJ
cord-289034-yl3emjef	106	10	and	and	CC
cord-289034-yl3emjef	106	11	anti	anti	JJ
cord-289034-yl3emjef	106	12	-	-	JJ
cord-289034-yl3emjef	106	13	oxidant	oxidant	JJ
cord-289034-yl3emjef	106	14	and	and	CC
cord-289034-yl3emjef	106	15	its	-PRON-	PRP$
cord-289034-yl3emjef	106	16	administration	administration	NN
cord-289034-yl3emjef	106	17	to	to	IN
cord-289034-yl3emjef	106	18	COVID-19	covid-19	VB
cord-289034-yl3emjef	106	19	patients	patient	NNS
cord-289034-yl3emjef	106	20	has	have	VBZ
cord-289034-yl3emjef	106	21	been	be	VBN
cord-289034-yl3emjef	106	22	recently	recently	RB
cord-289034-yl3emjef	106	23	proposed	propose	VBN
cord-289034-yl3emjef	106	24	as	as	IN
cord-289034-yl3emjef	106	25	potential	potential	JJ
cord-289034-yl3emjef	106	26	adjuvant	adjuvant	NN
cord-289034-yl3emjef	106	27	treatment	treatment	NN
cord-289034-yl3emjef	106	28	strategy	strategy	NN
cord-289034-yl3emjef	106	29	to	to	TO
cord-289034-yl3emjef	106	30	reduce	reduce	VB
cord-289034-yl3emjef	106	31	the	the	DT
cord-289034-yl3emjef	106	32	severity	severity	NN
cord-289034-yl3emjef	106	33	of	of	IN
cord-289034-yl3emjef	106	34	the	the	DT
cord-289034-yl3emjef	106	35	COVID-19	covid-19	JJ
cord-289034-yl3emjef	106	36	pandemic	pandemic	NN
cord-289034-yl3emjef	106	37	[	[	-LRB-
cord-289034-yl3emjef	106	38	34	34	CD
cord-289034-yl3emjef	106	39	]	]	-RRB-
cord-289034-yl3emjef	106	40	[	[	-LRB-
cord-289034-yl3emjef	106	41	35	35	CD
cord-289034-yl3emjef	106	42	]	]	-RRB-
cord-289034-yl3emjef	106	43	[	[	-LRB-
cord-289034-yl3emjef	106	44	36	36	CD
cord-289034-yl3emjef	106	45	]	]	-RRB-
cord-289034-yl3emjef	106	46	.	.	.
cord-289034-yl3emjef	107	1	Though	though	IN
cord-289034-yl3emjef	107	2	clinical	clinical	JJ
cord-289034-yl3emjef	107	3	evidences	evidence	NNS
cord-289034-yl3emjef	107	4	are	be	VBP
cord-289034-yl3emjef	107	5	not	not	RB
cord-289034-yl3emjef	107	6	yet	yet	RB
cord-289034-yl3emjef	107	7	available	available	JJ
cord-289034-yl3emjef	107	8	,	,	,
cord-289034-yl3emjef	107	9	several	several	JJ
cord-289034-yl3emjef	107	10	scientific	scientific	JJ
cord-289034-yl3emjef	107	11	data	data	NN
cord-289034-yl3emjef	107	12	supports	support	VBZ
cord-289034-yl3emjef	107	13	the	the	DT
cord-289034-yl3emjef	107	14	potential	potential	JJ
cord-289034-yl3emjef	107	15	utility	utility	NN
cord-289034-yl3emjef	107	16	of	of	IN
cord-289034-yl3emjef	107	17	melatonin	melatonin	NN
cord-289034-yl3emjef	107	18	to	to	TO
cord-289034-yl3emjef	107	19	attenuate	attenuate	VB
cord-289034-yl3emjef	107	20	the	the	DT
cord-289034-yl3emjef	107	21	worst	bad	JJS
cord-289034-yl3emjef	107	22	symptoms	symptom	NNS
cord-289034-yl3emjef	107	23	of	of	IN
cord-289034-yl3emjef	107	24	COVID-19	covid-19	JJ
cord-289034-yl3emjef	107	25	infection	infection	NN
cord-289034-yl3emjef	107	26	[	[	-LRB-
cord-289034-yl3emjef	107	27	37	37	CD
cord-289034-yl3emjef	107	28	,	,	,
cord-289034-yl3emjef	107	29	38	38	CD
cord-289034-yl3emjef	107	30	]	]	-RRB-
cord-289034-yl3emjef	107	31	.	.	.
cord-289034-yl3emjef	108	1	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	108	2	dysfunction	dysfunction	NN
cord-289034-yl3emjef	108	3	has	have	VBZ
cord-289034-yl3emjef	108	4	long	long	RB
cord-289034-yl3emjef	108	5	been	be	VBN
cord-289034-yl3emjef	108	6	recognized	recognize	VBN
cord-289034-yl3emjef	108	7	as	as	IN
cord-289034-yl3emjef	108	8	a	a	DT
cord-289034-yl3emjef	108	9	driver	driver	NN
cord-289034-yl3emjef	108	10	of	of	IN
cord-289034-yl3emjef	108	11	the	the	DT
cord-289034-yl3emjef	108	12	aging	aging	NN
cord-289034-yl3emjef	108	13	process	process	NN
cord-289034-yl3emjef	108	14	.	.	.
cord-289034-yl3emjef	109	1	Early	early	JJ
cord-289034-yl3emjef	109	2	studies	study	NNS
cord-289034-yl3emjef	109	3	have	have	VBP
cord-289034-yl3emjef	109	4	linked	link	VBN
cord-289034-yl3emjef	109	5	accumulation	accumulation	NN
cord-289034-yl3emjef	109	6	of	of	IN
cord-289034-yl3emjef	109	7	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	109	8	DNA	dna	NN
cord-289034-yl3emjef	109	9	mutations	mutation	NNS
cord-289034-yl3emjef	109	10	and	and	CC
cord-289034-yl3emjef	109	11	the	the	DT
cord-289034-yl3emjef	109	12	concomitant	concomitant	JJ
cord-289034-yl3emjef	109	13	decline	decline	NN
cord-289034-yl3emjef	109	14	in	in	IN
cord-289034-yl3emjef	109	15	ETC	ETC	NNP
cord-289034-yl3emjef	109	16	and	and	CC
cord-289034-yl3emjef	109	17	OXPHOS	OXPHOS	NNP
cord-289034-yl3emjef	109	18	activity	activity	NN
cord-289034-yl3emjef	109	19	to	to	IN
cord-289034-yl3emjef	109	20	aging	age	VBG
cord-289034-yl3emjef	109	21	[	[	-LRB-
cord-289034-yl3emjef	109	22	29	29	CD
cord-289034-yl3emjef	109	23	,	,	,
cord-289034-yl3emjef	109	24	39	39	CD
cord-289034-yl3emjef	109	25	]	]	-RRB-
cord-289034-yl3emjef	109	26	.	.	.
cord-289034-yl3emjef	110	1	Furthermore	furthermore	RB
cord-289034-yl3emjef	110	2	,	,	,
cord-289034-yl3emjef	110	3	genetic	genetic	JJ
cord-289034-yl3emjef	110	4	studies	study	NNS
cord-289034-yl3emjef	110	5	in	in	IN
cord-289034-yl3emjef	110	6	mice	mouse	NNS
cord-289034-yl3emjef	110	7	support	support	VBP
cord-289034-yl3emjef	110	8	a	a	DT
cord-289034-yl3emjef	110	9	causal	causal	JJ
cord-289034-yl3emjef	110	10	relation	relation	NN
cord-289034-yl3emjef	110	11	between	between	IN
cord-289034-yl3emjef	110	12	mtDNA	mtdna	JJ
cord-289034-yl3emjef	110	13	depletion	depletion	NN
cord-289034-yl3emjef	110	14	and	and	CC
cord-289034-yl3emjef	110	15	aging	age	VBG
cord-289034-yl3emjef	110	16	[	[	-LRB-
cord-289034-yl3emjef	110	17	40	40	CD
cord-289034-yl3emjef	110	18	]	]	-RRB-
cord-289034-yl3emjef	110	19	.	.	.
cord-289034-yl3emjef	111	1	Recent	recent	JJ
cord-289034-yl3emjef	111	2	evidences	evidence	NNS
cord-289034-yl3emjef	111	3	have	have	VBP
cord-289034-yl3emjef	111	4	confirmed	confirm	VBN
cord-289034-yl3emjef	111	5	that	that	IN
cord-289034-yl3emjef	111	6	healthy	healthy	JJ
cord-289034-yl3emjef	111	7	centenarians	centenarian	NNS
cord-289034-yl3emjef	111	8	retain	retain	VBP
cord-289034-yl3emjef	111	9	more	more	JJR
cord-289034-yl3emjef	111	10	"	"	``
cord-289034-yl3emjef	111	11	intact	intact	JJ
cord-289034-yl3emjef	111	12	"	"	''
cord-289034-yl3emjef	111	13	mtDNA	mtdna	JJ
cord-289034-yl3emjef	111	14	copies	copy	NNS
cord-289034-yl3emjef	111	15	than	than	IN
cord-289034-yl3emjef	111	16	old	old	JJ
cord-289034-yl3emjef	111	17	people	people	NNS
cord-289034-yl3emjef	111	18	and	and	CC
cord-289034-yl3emjef	111	19	frail	frail	JJ
cord-289034-yl3emjef	111	20	centenarians	centenarian	NNS
cord-289034-yl3emjef	111	21	[	[	-LRB-
cord-289034-yl3emjef	111	22	40	40	CD
cord-289034-yl3emjef	111	23	]	]	-RRB-
cord-289034-yl3emjef	111	24	,	,	,
cord-289034-yl3emjef	111	25	suggesting	suggest	VBG
cord-289034-yl3emjef	111	26	that	that	IN
cord-289034-yl3emjef	111	27	"	"	``
cord-289034-yl3emjef	111	28	healthy	healthy	JJ
cord-289034-yl3emjef	111	29	"	"	''
cord-289034-yl3emjef	111	30	mtDNA	mtdna	NN
cord-289034-yl3emjef	111	31	is	be	VBZ
cord-289034-yl3emjef	111	32	a	a	DT
cord-289034-yl3emjef	111	33	hallmark	hallmark	NN
cord-289034-yl3emjef	111	34	of	of	IN
cord-289034-yl3emjef	111	35	healthy	healthy	JJ
cord-289034-yl3emjef	111	36	aging	aging	NN
cord-289034-yl3emjef	111	37	.	.	.
cord-289034-yl3emjef	112	1	Besides	besides	IN
cord-289034-yl3emjef	112	2	the	the	DT
cord-289034-yl3emjef	112	3	mtDNA	mtdna	JJ
cord-289034-yl3emjef	112	4	status	status	NN
cord-289034-yl3emjef	112	5	,	,	,
cord-289034-yl3emjef	112	6	activation	activation	NN
cord-289034-yl3emjef	112	7	of	of	IN
cord-289034-yl3emjef	112	8	mitochondria	mitochondria	NN
cord-289034-yl3emjef	112	9	-	-	HYPH
cord-289034-yl3emjef	112	10	to	to	IN
cord-289034-yl3emjef	112	11	-	-	HYPH
cord-289034-yl3emjef	112	12	nucleus	nucleus	NN
cord-289034-yl3emjef	112	13	signaling	signal	VBG
cord-289034-yl3emjef	112	14	pathways	pathway	NNS
cord-289034-yl3emjef	112	15	,	,	,
cord-289034-yl3emjef	112	16	particularly	particularly	RB
cord-289034-yl3emjef	112	17	the	the	DT
cord-289034-yl3emjef	112	18	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	112	19	unfolded	unfold	VBD
cord-289034-yl3emjef	112	20	protein	protein	NN
cord-289034-yl3emjef	112	21	response	response	NN
cord-289034-yl3emjef	112	22	(	(	-LRB-
cord-289034-yl3emjef	112	23	UPR	UPR	NNP
cord-289034-yl3emjef	112	24	mt	mt	NNP
cord-289034-yl3emjef	112	25	)	)	-RRB-
cord-289034-yl3emjef	112	26	,	,	,
cord-289034-yl3emjef	112	27	has	have	VBZ
cord-289034-yl3emjef	112	28	been	be	VBN
cord-289034-yl3emjef	112	29	implicated	implicate	VBN
cord-289034-yl3emjef	112	30	in	in	IN
cord-289034-yl3emjef	112	31	aging	age	VBG
cord-289034-yl3emjef	112	32	.	.	.
cord-289034-yl3emjef	113	1	UPR	UPR	NNP
cord-289034-yl3emjef	113	2	mt	mt	NNP
cord-289034-yl3emjef	113	3	activation	activation	NN
cord-289034-yl3emjef	113	4	promotes	promote	VBZ
cord-289034-yl3emjef	113	5	transcription	transcription	NN
cord-289034-yl3emjef	113	6	of	of	IN
cord-289034-yl3emjef	113	7	several	several	JJ
cord-289034-yl3emjef	113	8	nuclear	nuclear	JJ
cord-289034-yl3emjef	113	9	genes	gene	NNS
cord-289034-yl3emjef	113	10	,	,	,
cord-289034-yl3emjef	113	11	such	such	JJ
cord-289034-yl3emjef	113	12	as	as	IN
cord-289034-yl3emjef	113	13	those	those	DT
cord-289034-yl3emjef	113	14	encoding	encode	VBG
cord-289034-yl3emjef	113	15	antioxidant	antioxidant	NN
cord-289034-yl3emjef	113	16	proteins	protein	NNS
cord-289034-yl3emjef	113	17	and	and	CC
cord-289034-yl3emjef	113	18	enzymes	enzyme	NNS
cord-289034-yl3emjef	113	19	,	,	,
cord-289034-yl3emjef	113	20	which	which	WDT
cord-289034-yl3emjef	113	21	support	support	VBP
cord-289034-yl3emjef	113	22	survival	survival	NN
cord-289034-yl3emjef	113	23	,	,	,
cord-289034-yl3emjef	113	24	gain	gain	NN
cord-289034-yl3emjef	113	25	of	of	IN
cord-289034-yl3emjef	113	26	the	the	DT
cord-289034-yl3emjef	113	27	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	113	28	functionality	functionality	NN
cord-289034-yl3emjef	113	29	and	and	CC
cord-289034-yl3emjef	113	30	,	,	,
cord-289034-yl3emjef	113	31	thus	thus	RB
cord-289034-yl3emjef	113	32	,	,	,
cord-289034-yl3emjef	113	33	longevity	longevity	NN
cord-289034-yl3emjef	113	34	and	and	CC
cord-289034-yl3emjef	113	35	lifespan	lifespan	NN
cord-289034-yl3emjef	113	36	[	[	-LRB-
cord-289034-yl3emjef	113	37	41	41	CD
cord-289034-yl3emjef	113	38	]	]	-RRB-
cord-289034-yl3emjef	113	39	.	.	.
cord-289034-yl3emjef	114	1	It	-PRON-	PRP
cord-289034-yl3emjef	114	2	should	should	MD
cord-289034-yl3emjef	114	3	be	be	VB
cord-289034-yl3emjef	114	4	noted	note	VBN
cord-289034-yl3emjef	114	5	that	that	IN
cord-289034-yl3emjef	114	6	if	if	IN
cord-289034-yl3emjef	114	7	a	a	DT
cord-289034-yl3emjef	114	8	heteroplasmic	heteroplasmic	NNP
cord-289034-yl3emjef	114	9	mtDNA	mtdna	JJ
cord-289034-yl3emjef	114	10	pool	pool	NN
cord-289034-yl3emjef	114	11	is	be	VBZ
cord-289034-yl3emjef	114	12	present	present	JJ
cord-289034-yl3emjef	114	13	,	,	,
cord-289034-yl3emjef	114	14	UPR	UPR	NNP
cord-289034-yl3emjef	114	15	mt	mt	NNP
cord-289034-yl3emjef	114	16	activation	activation	NN
cord-289034-yl3emjef	114	17	could	could	MD
cord-289034-yl3emjef	114	18	exacerbate	exacerbate	VB
cord-289034-yl3emjef	114	19	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	114	20	dysfunction	dysfunction	NN
cord-289034-yl3emjef	114	21	as	as	IN
cord-289034-yl3emjef	114	22	it	-PRON-	PRP
cord-289034-yl3emjef	114	23	may	may	MD
cord-289034-yl3emjef	114	24	lead	lead	VB
cord-289034-yl3emjef	114	25	to	to	IN
cord-289034-yl3emjef	114	26	accumulation	accumulation	NN
cord-289034-yl3emjef	114	27	of	of	IN
cord-289034-yl3emjef	114	28	mutant	mutant	JJ
cord-289034-yl3emjef	114	29	mtDNA	mtdna	NN
cord-289034-yl3emjef	114	30	[	[	-LRB-
cord-289034-yl3emjef	114	31	42	42	CD
cord-289034-yl3emjef	114	32	]	]	-RRB-
cord-289034-yl3emjef	114	33	.	.	.
cord-289034-yl3emjef	115	1	Alterations	alteration	NNS
cord-289034-yl3emjef	115	2	in	in	IN
cord-289034-yl3emjef	115	3	the	the	DT
cord-289034-yl3emjef	115	4	removal	removal	NN
cord-289034-yl3emjef	115	5	of	of	IN
cord-289034-yl3emjef	115	6	damaged	damaged	JJ
cord-289034-yl3emjef	115	7	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	115	8	through	through	IN
cord-289034-yl3emjef	115	9	mitophagy	mitophagy	NNS
cord-289034-yl3emjef	115	10	have	have	VBP
cord-289034-yl3emjef	115	11	also	also	RB
cord-289034-yl3emjef	115	12	been	be	VBN
cord-289034-yl3emjef	115	13	implicated	implicate	VBN
cord-289034-yl3emjef	115	14	in	in	IN
cord-289034-yl3emjef	115	15	aging	age	VBG
cord-289034-yl3emjef	115	16	.	.	.
cord-289034-yl3emjef	116	1	Mitophagy	Mitophagy	NNP
cord-289034-yl3emjef	116	2	markedly	markedly	RB
cord-289034-yl3emjef	116	3	decreases	decrease	VBZ
cord-289034-yl3emjef	116	4	during	during	IN
cord-289034-yl3emjef	116	5	aging	age	VBG
cord-289034-yl3emjef	116	6	in	in	IN
cord-289034-yl3emjef	116	7	mammalian	mammalian	JJ
cord-289034-yl3emjef	116	8	tissues	tissue	NNS
cord-289034-yl3emjef	116	9	and	and	CC
cord-289034-yl3emjef	116	10	organs	organ	NNS
cord-289034-yl3emjef	116	11	[	[	-LRB-
cord-289034-yl3emjef	116	12	43	43	CD
cord-289034-yl3emjef	116	13	,	,	,
cord-289034-yl3emjef	116	14	44	44	CD
cord-289034-yl3emjef	116	15	]	]	-RRB-
cord-289034-yl3emjef	116	16	and	and	CC
cord-289034-yl3emjef	116	17	this	this	DT
cord-289034-yl3emjef	116	18	may	may	MD
cord-289034-yl3emjef	116	19	be	be	VB
cord-289034-yl3emjef	116	20	responsible	responsible	JJ
cord-289034-yl3emjef	116	21	for	for	IN
cord-289034-yl3emjef	116	22	the	the	DT
cord-289034-yl3emjef	116	23	known	know	VBN
cord-289034-yl3emjef	116	24	accumulation	accumulation	NN
cord-289034-yl3emjef	116	25	of	of	IN
cord-289034-yl3emjef	116	26	damaged	damaged	JJ
cord-289034-yl3emjef	116	27	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	116	28	in	in	IN
cord-289034-yl3emjef	116	29	aging	age	VBG
cord-289034-yl3emjef	116	30	tissues	tissue	NNS
cord-289034-yl3emjef	116	31	.	.	.
cord-289034-yl3emjef	117	1	Notably	notably	RB
cord-289034-yl3emjef	117	2	,	,	,
cord-289034-yl3emjef	117	3	genetic	genetic	JJ
cord-289034-yl3emjef	117	4	manipulations	manipulation	NNS
cord-289034-yl3emjef	117	5	in	in	IN
cord-289034-yl3emjef	117	6	C.	C.	NNP
cord-289034-yl3emjef	117	7	elegans	elegan	NNS
cord-289034-yl3emjef	117	8	that	that	WDT
cord-289034-yl3emjef	117	9	increase	increase	VBP
cord-289034-yl3emjef	117	10	mitophagy	mitophagy	NN
cord-289034-yl3emjef	117	11	also	also	RB
cord-289034-yl3emjef	117	12	extend	extend	VBP
cord-289034-yl3emjef	117	13	the	the	DT
cord-289034-yl3emjef	117	14	organismal	organismal	JJ
cord-289034-yl3emjef	117	15	lifespan	lifespan	NN
cord-289034-yl3emjef	117	16	[	[	-LRB-
cord-289034-yl3emjef	117	17	45	45	CD
cord-289034-yl3emjef	117	18	]	]	-RRB-
cord-289034-yl3emjef	117	19	,	,	,
cord-289034-yl3emjef	117	20	strengthening	strengthen	VBG
cord-289034-yl3emjef	117	21	the	the	DT
cord-289034-yl3emjef	117	22	connection	connection	NN
cord-289034-yl3emjef	117	23	between	between	IN
cord-289034-yl3emjef	117	24	altered	altered	JJ
cord-289034-yl3emjef	117	25	mitophagy	mitophagy	NN
cord-289034-yl3emjef	117	26	and	and	CC
cord-289034-yl3emjef	117	27	aging	aging	NN
cord-289034-yl3emjef	117	28	.	.	.
cord-289034-yl3emjef	118	1	Neurodegenerative	neurodegenerative	JJ
cord-289034-yl3emjef	118	2	diseases	disease	NNS
cord-289034-yl3emjef	118	3	are	be	VBP
cord-289034-yl3emjef	118	4	characterized	characterize	VBN
cord-289034-yl3emjef	118	5	by	by	IN
cord-289034-yl3emjef	118	6	changes	change	NNS
cord-289034-yl3emjef	118	7	in	in	IN
cord-289034-yl3emjef	118	8	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	118	9	morphology	morphology	NN
cord-289034-yl3emjef	118	10	and	and	CC
cord-289034-yl3emjef	118	11	biochemical	biochemical	JJ
cord-289034-yl3emjef	118	12	activity	activity	NN
cord-289034-yl3emjef	118	13	.	.	.
cord-289034-yl3emjef	119	1	Alzheimer	Alzheimer	NNP
cord-289034-yl3emjef	119	2	's	's	POS
cord-289034-yl3emjef	119	3	(	(	-LRB-
cord-289034-yl3emjef	119	4	AD	ad	NN
cord-289034-yl3emjef	119	5	)	)	-RRB-
cord-289034-yl3emjef	119	6	and	and	CC
cord-289034-yl3emjef	120	1	Parkinson	Parkinson	NNP
cord-289034-yl3emjef	120	2	's	's	POS
cord-289034-yl3emjef	120	3	(	(	-LRB-
cord-289034-yl3emjef	120	4	PD	PD	NNP
cord-289034-yl3emjef	120	5	)	)	-RRB-
cord-289034-yl3emjef	120	6	disease	disease	NN
cord-289034-yl3emjef	120	7	are	be	VBP
cord-289034-yl3emjef	120	8	the	the	DT
cord-289034-yl3emjef	120	9	most	most	RBS
cord-289034-yl3emjef	120	10	diffuse	diffuse	JJ
cord-289034-yl3emjef	120	11	neurodegenerative	neurodegenerative	JJ
cord-289034-yl3emjef	120	12	illnesses	illness	NNS
cord-289034-yl3emjef	120	13	among	among	IN
cord-289034-yl3emjef	120	14	older	old	JJR
cord-289034-yl3emjef	120	15	adults	adult	NNS
cord-289034-yl3emjef	120	16	.	.	.
cord-289034-yl3emjef	121	1	Brain	brain	NN
cord-289034-yl3emjef	121	2	cells	cell	NNS
cord-289034-yl3emjef	121	3	from	from	IN
cord-289034-yl3emjef	121	4	AD	ad	NN
cord-289034-yl3emjef	121	5	and	and	CC
cord-289034-yl3emjef	121	6	PD	PD	NNP
cord-289034-yl3emjef	121	7	patients	patient	NNS
cord-289034-yl3emjef	121	8	show	show	VBP
cord-289034-yl3emjef	121	9	reduced	reduced	JJ
cord-289034-yl3emjef	121	10	respiratory	respiratory	JJ
cord-289034-yl3emjef	121	11	activity	activity	NN
cord-289034-yl3emjef	121	12	and	and	CC
cord-289034-yl3emjef	121	13	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	121	14	biogenesis	biogenesis	NN
cord-289034-yl3emjef	121	15	[	[	-LRB-
cord-289034-yl3emjef	121	16	46	46	CD
cord-289034-yl3emjef	121	17	,	,	,
cord-289034-yl3emjef	121	18	47	47	CD
cord-289034-yl3emjef	121	19	]	]	-RRB-
cord-289034-yl3emjef	121	20	.	.	.
cord-289034-yl3emjef	122	1	A	a	DT
cord-289034-yl3emjef	122	2	prominent	prominent	JJ
cord-289034-yl3emjef	122	3	pathological	pathological	JJ
cord-289034-yl3emjef	122	4	feature	feature	NN
cord-289034-yl3emjef	122	5	of	of	IN
cord-289034-yl3emjef	122	6	AD	ad	NN
cord-289034-yl3emjef	122	7	is	be	VBZ
cord-289034-yl3emjef	122	8	the	the	DT
cord-289034-yl3emjef	122	9	impaired	impaired	JJ
cord-289034-yl3emjef	122	10	cerebral	cerebral	JJ
cord-289034-yl3emjef	122	11	glucose	glucose	NN
cord-289034-yl3emjef	122	12	metabolism	metabolism	NN
cord-289034-yl3emjef	122	13	,	,	,
cord-289034-yl3emjef	122	14	which	which	WDT
cord-289034-yl3emjef	122	15	is	be	VBZ
cord-289034-yl3emjef	122	16	reduced	reduce	VBN
cord-289034-yl3emjef	122	17	by	by	IN
cord-289034-yl3emjef	122	18	45	45	CD
cord-289034-yl3emjef	122	19	%	%	NN
cord-289034-yl3emjef	122	20	in	in	IN
cord-289034-yl3emjef	122	21	the	the	DT
cord-289034-yl3emjef	122	22	early	early	JJ
cord-289034-yl3emjef	122	23	stages	stage	NNS
cord-289034-yl3emjef	122	24	,	,	,
cord-289034-yl3emjef	122	25	preceding	precede	VBG
cord-289034-yl3emjef	122	26	neurological	neurological	JJ
cord-289034-yl3emjef	122	27	impairment	impairment	NN
cord-289034-yl3emjef	122	28	and	and	CC
cord-289034-yl3emjef	122	29	atrophy	atrophy	NN
cord-289034-yl3emjef	122	30	,	,	,
cord-289034-yl3emjef	122	31	and	and	CC
cord-289034-yl3emjef	122	32	further	further	JJ
cord-289034-yl3emjef	122	33	declines	decline	NNS
cord-289034-yl3emjef	122	34	in	in	IN
cord-289034-yl3emjef	122	35	the	the	DT
cord-289034-yl3emjef	122	36	late	late	JJ
cord-289034-yl3emjef	122	37	stages	stage	NNS
cord-289034-yl3emjef	122	38	of	of	IN
cord-289034-yl3emjef	122	39	the	the	DT
cord-289034-yl3emjef	122	40	disease	disease	NN
cord-289034-yl3emjef	122	41	[	[	-LRB-
cord-289034-yl3emjef	122	42	48	48	CD
cord-289034-yl3emjef	122	43	]	]	-RRB-
cord-289034-yl3emjef	122	44	.	.	.
cord-289034-yl3emjef	123	1	The	the	DT
cord-289034-yl3emjef	123	2	decrease	decrease	NN
cord-289034-yl3emjef	123	3	in	in	IN
cord-289034-yl3emjef	123	4	glucose	glucose	NN
cord-289034-yl3emjef	123	5	metabolism	metabolism	NN
cord-289034-yl3emjef	123	6	is	be	VBZ
cord-289034-yl3emjef	123	7	associated	associate	VBN
cord-289034-yl3emjef	123	8	with	with	IN
cord-289034-yl3emjef	123	9	reduced	reduced	JJ
cord-289034-yl3emjef	123	10	expression	expression	NN
cord-289034-yl3emjef	123	11	and	and	CC
cord-289034-yl3emjef	123	12	activity	activity	NN
cord-289034-yl3emjef	123	13	of	of	IN
cord-289034-yl3emjef	123	14	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	123	15	enzymes	enzyme	NNS
cord-289034-yl3emjef	123	16	,	,	,
cord-289034-yl3emjef	123	17	including	include	VBG
cord-289034-yl3emjef	123	18	pyruvate	pyruvate	NN
cord-289034-yl3emjef	123	19	dehydrogenase	dehydrogenase	NN
cord-289034-yl3emjef	123	20	,	,	,
cord-289034-yl3emjef	123	21	isocitrate	isocitrate	JJ
cord-289034-yl3emjef	123	22	dehydrogenase	dehydrogenase	NN
cord-289034-yl3emjef	123	23	and	and	CC
cord-289034-yl3emjef	123	24	α	α	NN
cord-289034-yl3emjef	123	25	-	-	HYPH
cord-289034-yl3emjef	123	26	ketoglutarate	ketoglutarate	NN
cord-289034-yl3emjef	123	27	dehydrogenase	dehydrogenase	NN
cord-289034-yl3emjef	123	28	,	,	,
cord-289034-yl3emjef	123	29	three	three	CD
cord-289034-yl3emjef	123	30	enzymes	enzyme	NNS
cord-289034-yl3emjef	123	31	of	of	IN
cord-289034-yl3emjef	123	32	the	the	DT
cord-289034-yl3emjef	123	33	TCA	TCA	NNP
cord-289034-yl3emjef	123	34	cycle	cycle	NN
cord-289034-yl3emjef	123	35	[	[	-LRB-
cord-289034-yl3emjef	123	36	49	49	CD
cord-289034-yl3emjef	123	37	]	]	-RRB-
cord-289034-yl3emjef	123	38	.	.	.
cord-289034-yl3emjef	124	1	In	in	IN
cord-289034-yl3emjef	124	2	addition	addition	NN
cord-289034-yl3emjef	124	3	,	,	,
cord-289034-yl3emjef	124	4	reduced	reduced	JJ
cord-289034-yl3emjef	124	5	activity	activity	NN
cord-289034-yl3emjef	124	6	of	of	IN
cord-289034-yl3emjef	124	7	the	the	DT
cord-289034-yl3emjef	124	8	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	124	9	respiratory	respiratory	JJ
cord-289034-yl3emjef	124	10	complexes	complex	NNS
cord-289034-yl3emjef	124	11	I	-PRON-	PRP
cord-289034-yl3emjef	124	12	,	,	,
cord-289034-yl3emjef	124	13	II	II	NNP
cord-289034-yl3emjef	124	14	,	,	,
cord-289034-yl3emjef	124	15	III	III	NNP
cord-289034-yl3emjef	124	16	and	and	CC
cord-289034-yl3emjef	124	17	IV	IV	NNP
cord-289034-yl3emjef	124	18	has	have	VBZ
cord-289034-yl3emjef	124	19	also	also	RB
cord-289034-yl3emjef	124	20	been	be	VBN
cord-289034-yl3emjef	124	21	documented	document	VBN
cord-289034-yl3emjef	124	22	[	[	-LRB-
cord-289034-yl3emjef	124	23	46	46	CD
cord-289034-yl3emjef	124	24	]	]	-RRB-
cord-289034-yl3emjef	124	25	.	.	.
cord-289034-yl3emjef	125	1	Somatic	somatic	JJ
cord-289034-yl3emjef	125	2	mutations	mutation	NNS
cord-289034-yl3emjef	125	3	in	in	IN
cord-289034-yl3emjef	125	4	the	the	DT
cord-289034-yl3emjef	125	5	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	125	6	genome	genome	NN
cord-289034-yl3emjef	125	7	have	have	VBP
cord-289034-yl3emjef	125	8	been	be	VBN
cord-289034-yl3emjef	125	9	detected	detect	VBN
cord-289034-yl3emjef	125	10	in	in	IN
cord-289034-yl3emjef	125	11	postmortem	postmortem	JJ
cord-289034-yl3emjef	125	12	brain	brain	NN
cord-289034-yl3emjef	125	13	tissue	tissue	NN
cord-289034-yl3emjef	125	14	from	from	IN
cord-289034-yl3emjef	125	15	AD	ad	NN
cord-289034-yl3emjef	125	16	patients	patient	NNS
cord-289034-yl3emjef	125	17	,	,	,
cord-289034-yl3emjef	125	18	at	at	IN
cord-289034-yl3emjef	125	19	levels	level	NNS
cord-289034-yl3emjef	125	20	higher	high	JJR
cord-289034-yl3emjef	125	21	than	than	IN
cord-289034-yl3emjef	125	22	in	in	IN
cord-289034-yl3emjef	125	23	healthy	healthy	JJ
cord-289034-yl3emjef	125	24	brains	brain	NNS
cord-289034-yl3emjef	125	25	[	[	-LRB-
cord-289034-yl3emjef	125	26	50	50	CD
cord-289034-yl3emjef	125	27	]	]	-RRB-
cord-289034-yl3emjef	125	28	.	.	.
cord-289034-yl3emjef	126	1	These	these	DT
cord-289034-yl3emjef	126	2	mutations	mutation	NNS
cord-289034-yl3emjef	126	3	may	may	MD
cord-289034-yl3emjef	126	4	not	not	RB
cord-289034-yl3emjef	126	5	only	only	RB
cord-289034-yl3emjef	126	6	affect	affect	VB
cord-289034-yl3emjef	126	7	the	the	DT
cord-289034-yl3emjef	126	8	ETC	ETC	NNS
cord-289034-yl3emjef	126	9	but	but	CC
cord-289034-yl3emjef	126	10	also	also	RB
cord-289034-yl3emjef	126	11	trigger	trigger	VB
cord-289034-yl3emjef	126	12	other	other	JJ
cord-289034-yl3emjef	126	13	neuropathological	neuropathological	JJ
cord-289034-yl3emjef	126	14	consequences	consequence	NNS
cord-289034-yl3emjef	126	15	,	,	,
cord-289034-yl3emjef	126	16	such	such	JJ
cord-289034-yl3emjef	126	17	as	as	IN
cord-289034-yl3emjef	126	18	increased	increase	VBN
cord-289034-yl3emjef	126	19	ROS	ROS	NNP
cord-289034-yl3emjef	126	20	production	production	NN
cord-289034-yl3emjef	126	21	and	and	CC
cord-289034-yl3emjef	126	22	oxidative	oxidative	JJ
cord-289034-yl3emjef	126	23	stress	stress	NN
cord-289034-yl3emjef	126	24	in	in	IN
cord-289034-yl3emjef	126	25	neurons	neuron	NNS
cord-289034-yl3emjef	126	26	and	and	CC
cord-289034-yl3emjef	126	27	promotion	promotion	NN
cord-289034-yl3emjef	126	28	of	of	IN
cord-289034-yl3emjef	126	29	amyloidogenic	amyloidogenic	NNP
cord-289034-yl3emjef	126	30	processing	processing	NN
cord-289034-yl3emjef	126	31	of	of	IN
cord-289034-yl3emjef	126	32	the	the	DT
cord-289034-yl3emjef	126	33	amyloid	amyloid	NN
cord-289034-yl3emjef	126	34	precursor	precursor	NN
cord-289034-yl3emjef	126	35	protein	protein	NN
cord-289034-yl3emjef	126	36	.	.	.
cord-289034-yl3emjef	127	1	Mitophagy	Mitophagy	NNP
cord-289034-yl3emjef	127	2	is	be	VBZ
cord-289034-yl3emjef	127	3	also	also	RB
cord-289034-yl3emjef	127	4	diminished	diminish	VBN
cord-289034-yl3emjef	127	5	in	in	IN
cord-289034-yl3emjef	127	6	AD	ad	NN
cord-289034-yl3emjef	127	7	's	's	POS
cord-289034-yl3emjef	127	8	neurons	neuron	NNS
cord-289034-yl3emjef	127	9	,	,	,
cord-289034-yl3emjef	127	10	and	and	CC
cord-289034-yl3emjef	127	11	this	this	DT
cord-289034-yl3emjef	127	12	may	may	MD
cord-289034-yl3emjef	127	13	contribute	contribute	VB
cord-289034-yl3emjef	127	14	to	to	IN
cord-289034-yl3emjef	127	15	the	the	DT
cord-289034-yl3emjef	127	16	etiopathogenesis	etiopathogenesis	NN
cord-289034-yl3emjef	127	17	of	of	IN
cord-289034-yl3emjef	127	18	AD	AD	NNP
cord-289034-yl3emjef	127	19	.	.	.
cord-289034-yl3emjef	128	1	Indeed	indeed	RB
cord-289034-yl3emjef	128	2	,	,	,
cord-289034-yl3emjef	128	3	mitophagy	mitophagy	NNP
cord-289034-yl3emjef	128	4	was	be	VBD
cord-289034-yl3emjef	128	5	able	able	JJ
cord-289034-yl3emjef	128	6	to	to	TO
cord-289034-yl3emjef	128	7	prevent	prevent	VB
cord-289034-yl3emjef	128	8	or	or	CC
cord-289034-yl3emjef	128	9	reverse	reverse	VB
cord-289034-yl3emjef	128	10	the	the	DT
cord-289034-yl3emjef	128	11	cognitive	cognitive	JJ
cord-289034-yl3emjef	128	12	impairment	impairment	NN
cord-289034-yl3emjef	128	13	in	in	IN
cord-289034-yl3emjef	128	14	several	several	JJ
cord-289034-yl3emjef	128	15	AD	ad	NN
cord-289034-yl3emjef	128	16	models	model	NNS
cord-289034-yl3emjef	128	17	[	[	-LRB-
cord-289034-yl3emjef	128	18	51	51	CD
cord-289034-yl3emjef	128	19	]	]	-RRB-
cord-289034-yl3emjef	128	20	,	,	,
cord-289034-yl3emjef	128	21	confirming	confirm	VBG
cord-289034-yl3emjef	128	22	the	the	DT
cord-289034-yl3emjef	128	23	critical	critical	JJ
cord-289034-yl3emjef	128	24	involvement	involvement	NN
cord-289034-yl3emjef	128	25	of	of	IN
cord-289034-yl3emjef	128	26	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	128	27	in	in	IN
cord-289034-yl3emjef	128	28	AD	ad	NN
cord-289034-yl3emjef	128	29	.	.	.
cord-289034-yl3emjef	129	1	Mutations	mutation	NNS
cord-289034-yl3emjef	129	2	in	in	IN
cord-289034-yl3emjef	129	3	nuclear	nuclear	JJ
cord-289034-yl3emjef	129	4	genes	gene	NNS
cord-289034-yl3emjef	129	5	encoding	encode	VBG
cord-289034-yl3emjef	129	6	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	129	7	proteins	protein	NNS
cord-289034-yl3emjef	129	8	important	important	JJ
cord-289034-yl3emjef	129	9	for	for	IN
cord-289034-yl3emjef	129	10	the	the	DT
cord-289034-yl3emjef	129	11	proper	proper	JJ
cord-289034-yl3emjef	129	12	function	function	NN
cord-289034-yl3emjef	129	13	of	of	IN
cord-289034-yl3emjef	129	14	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	129	15	have	have	VBP
cord-289034-yl3emjef	129	16	been	be	VBN
cord-289034-yl3emjef	129	17	directly	directly	RB
cord-289034-yl3emjef	129	18	linked	link	VBN
cord-289034-yl3emjef	129	19	to	to	IN
cord-289034-yl3emjef	129	20	PD	PD	NNP
cord-289034-yl3emjef	129	21	.	.	.
cord-289034-yl3emjef	130	1	Notably	notably	RB
cord-289034-yl3emjef	130	2	,	,	,
cord-289034-yl3emjef	130	3	mutations	mutation	NNS
cord-289034-yl3emjef	130	4	in	in	IN
cord-289034-yl3emjef	130	5	proteins	protein	NNS
cord-289034-yl3emjef	130	6	involved	involve	VBN
cord-289034-yl3emjef	130	7	in	in	IN
cord-289034-yl3emjef	130	8	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	130	9	quality	quality	NN
cord-289034-yl3emjef	130	10	control	control	NN
cord-289034-yl3emjef	130	11	,	,	,
cord-289034-yl3emjef	130	12	such	such	JJ
cord-289034-yl3emjef	130	13	as	as	IN
cord-289034-yl3emjef	130	14	PINK1	PINK1	NNP
cord-289034-yl3emjef	130	15	,	,	,
cord-289034-yl3emjef	130	16	Parkin	Parkin	NNP
cord-289034-yl3emjef	130	17	and	and	CC
cord-289034-yl3emjef	130	18	LRRK2	LRRK2	NNS
cord-289034-yl3emjef	130	19	,	,	,
cord-289034-yl3emjef	130	20	are	be	VBP
cord-289034-yl3emjef	130	21	a	a	DT
cord-289034-yl3emjef	130	22	frequent	frequent	JJ
cord-289034-yl3emjef	130	23	cause	cause	NN
cord-289034-yl3emjef	130	24	of	of	IN
cord-289034-yl3emjef	130	25	monogenic	monogenic	NNP
cord-289034-yl3emjef	130	26	PD	PD	NNP
cord-289034-yl3emjef	130	27	[	[	-LRB-
cord-289034-yl3emjef	130	28	52	52	CD
cord-289034-yl3emjef	130	29	]	]	-RRB-
cord-289034-yl3emjef	130	30	.	.	.
cord-289034-yl3emjef	131	1	Loss	loss	NN
cord-289034-yl3emjef	131	2	or	or	CC
cord-289034-yl3emjef	131	3	impaired	impaired	JJ
cord-289034-yl3emjef	131	4	functionality	functionality	NN
cord-289034-yl3emjef	131	5	of	of	IN
cord-289034-yl3emjef	131	6	these	these	DT
cord-289034-yl3emjef	131	7	proteins	protein	NNS
cord-289034-yl3emjef	131	8	results	result	NNS
cord-289034-yl3emjef	131	9	in	in	IN
cord-289034-yl3emjef	131	10	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	131	11	fragmentation	fragmentation	NN
cord-289034-yl3emjef	131	12	,	,	,
cord-289034-yl3emjef	131	13	dysregulation	dysregulation	NN
cord-289034-yl3emjef	131	14	of	of	IN
cord-289034-yl3emjef	131	15	calcium	calcium	NN
cord-289034-yl3emjef	131	16	homeostasis	homeostasis	NN
cord-289034-yl3emjef	131	17	and	and	CC
cord-289034-yl3emjef	131	18	changes	change	NNS
cord-289034-yl3emjef	131	19	in	in	IN
cord-289034-yl3emjef	131	20	mitochondria	mitochondria	NN
cord-289034-yl3emjef	131	21	-	-	HYPH
cord-289034-yl3emjef	131	22	endoplasmic	endoplasmic	NN
cord-289034-yl3emjef	131	23	reticulum	reticulum	NN
cord-289034-yl3emjef	131	24	contact	contact	NN
cord-289034-yl3emjef	131	25	sites	site	NNS
cord-289034-yl3emjef	131	26	(	(	-LRB-
cord-289034-yl3emjef	131	27	MERCs	MERCs	NNP
cord-289034-yl3emjef	131	28	)	)	-RRB-
cord-289034-yl3emjef	131	29	.	.	.
cord-289034-yl3emjef	132	1	Recently	recently	RB
cord-289034-yl3emjef	132	2	,	,	,
cord-289034-yl3emjef	132	3	mutations	mutation	NNS
cord-289034-yl3emjef	132	4	in	in	IN
cord-289034-yl3emjef	132	5	Miro1	Miro1	NNP
cord-289034-yl3emjef	132	6	,	,	,
cord-289034-yl3emjef	132	7	a	a	DT
cord-289034-yl3emjef	132	8	protein	protein	NN
cord-289034-yl3emjef	132	9	important	important	JJ
cord-289034-yl3emjef	132	10	for	for	IN
cord-289034-yl3emjef	132	11	the	the	DT
cord-289034-yl3emjef	132	12	regulation	regulation	NN
cord-289034-yl3emjef	132	13	of	of	IN
cord-289034-yl3emjef	132	14	the	the	DT
cord-289034-yl3emjef	132	15	structure	structure	NN
cord-289034-yl3emjef	132	16	and	and	CC
cord-289034-yl3emjef	132	17	function	function	NN
cord-289034-yl3emjef	132	18	of	of	IN
cord-289034-yl3emjef	132	19	MERCs	merc	NNS
cord-289034-yl3emjef	132	20	,	,	,
cord-289034-yl3emjef	132	21	have	have	VBP
cord-289034-yl3emjef	132	22	been	be	VBN
cord-289034-yl3emjef	132	23	causally	causally	RB
cord-289034-yl3emjef	132	24	linked	link	VBN
cord-289034-yl3emjef	132	25	to	to	IN
cord-289034-yl3emjef	132	26	PD	PD	NNP
cord-289034-yl3emjef	132	27	establishing	establish	VBG
cord-289034-yl3emjef	132	28	that	that	IN
cord-289034-yl3emjef	132	29	variants	variant	NNS
cord-289034-yl3emjef	132	30	in	in	IN
cord-289034-yl3emjef	132	31	the	the	DT
cord-289034-yl3emjef	132	32	gene	gene	NN
cord-289034-yl3emjef	132	33	encoding	encoding	NN
cord-289034-yl3emjef	132	34	for	for	IN
cord-289034-yl3emjef	132	35	Miro1	miro1	JJ
cord-289034-yl3emjef	132	36	represent	represent	VBP
cord-289034-yl3emjef	132	37	rare	rare	JJ
cord-289034-yl3emjef	132	38	genetic	genetic	JJ
cord-289034-yl3emjef	132	39	risk	risk	NN
cord-289034-yl3emjef	132	40	factors	factor	NNS
cord-289034-yl3emjef	132	41	for	for	IN
cord-289034-yl3emjef	132	42	neurodegenerative	neurodegenerative	JJ
cord-289034-yl3emjef	132	43	diseases	disease	NNS
cord-289034-yl3emjef	132	44	like	like	IN
cord-289034-yl3emjef	132	45	PD	PD	NNP
cord-289034-yl3emjef	132	46	(	(	-LRB-
cord-289034-yl3emjef	132	47	[	[	-LRB-
cord-289034-yl3emjef	132	48	53	53	CD
cord-289034-yl3emjef	132	49	]	]	-RRB-
cord-289034-yl3emjef	132	50	and	and	CC
cord-289034-yl3emjef	132	51	references	reference	NNS
cord-289034-yl3emjef	132	52	therein	therein	RB
cord-289034-yl3emjef	132	53	)	)	-RRB-
cord-289034-yl3emjef	132	54	.	.	.
cord-289034-yl3emjef	133	1	Although	although	IN
cord-289034-yl3emjef	133	2	there	there	EX
cord-289034-yl3emjef	133	3	is	be	VBZ
cord-289034-yl3emjef	133	4	no	no	DT
cord-289034-yl3emjef	133	5	doubt	doubt	NN
cord-289034-yl3emjef	133	6	about	about	IN
cord-289034-yl3emjef	133	7	the	the	DT
cord-289034-yl3emjef	133	8	involvement	involvement	NN
cord-289034-yl3emjef	133	9	of	of	IN
cord-289034-yl3emjef	133	10	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	133	11	dysfunction	dysfunction	NN
cord-289034-yl3emjef	133	12	in	in	IN
cord-289034-yl3emjef	133	13	AD	ad	NN
cord-289034-yl3emjef	133	14	and	and	CC
cord-289034-yl3emjef	133	15	PD	PD	NNP
cord-289034-yl3emjef	133	16	,	,	,
cord-289034-yl3emjef	133	17	still	still	RB
cord-289034-yl3emjef	133	18	more	more	JJR
cord-289034-yl3emjef	133	19	research	research	NN
cord-289034-yl3emjef	133	20	is	be	VBZ
cord-289034-yl3emjef	133	21	required	require	VBN
cord-289034-yl3emjef	133	22	to	to	TO
cord-289034-yl3emjef	133	23	identify	identify	VB
cord-289034-yl3emjef	133	24	therapeutic	therapeutic	JJ
cord-289034-yl3emjef	133	25	targets	target	NNS
cord-289034-yl3emjef	133	26	that	that	WDT
cord-289034-yl3emjef	133	27	could	could	MD
cord-289034-yl3emjef	133	28	improve	improve	VB
cord-289034-yl3emjef	133	29	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	133	30	activity	activity	NN
cord-289034-yl3emjef	133	31	and	and	CC
cord-289034-yl3emjef	133	32	reduce	reduce	VB
cord-289034-yl3emjef	133	33	oxidative	oxidative	JJ
cord-289034-yl3emjef	133	34	stress	stress	NN
cord-289034-yl3emjef	133	35	in	in	IN
cord-289034-yl3emjef	133	36	neurons	neuron	NNS
cord-289034-yl3emjef	133	37	in	in	IN
cord-289034-yl3emjef	133	38	the	the	DT
cord-289034-yl3emjef	133	39	early	early	JJ
cord-289034-yl3emjef	133	40	stages	stage	NNS
cord-289034-yl3emjef	133	41	of	of	IN
cord-289034-yl3emjef	133	42	these	these	DT
cord-289034-yl3emjef	133	43	neurodegenerative	neurodegenerative	JJ
cord-289034-yl3emjef	133	44	diseases	disease	NNS
cord-289034-yl3emjef	133	45	.	.	.
cord-289034-yl3emjef	134	1	Future	future	JJ
cord-289034-yl3emjef	134	2	studies	study	NNS
cord-289034-yl3emjef	134	3	should	should	MD
cord-289034-yl3emjef	134	4	be	be	VB
cord-289034-yl3emjef	134	5	aimed	aim	VBN
cord-289034-yl3emjef	134	6	at	at	IN
cord-289034-yl3emjef	134	7	investigating	investigate	VBG
cord-289034-yl3emjef	134	8	the	the	DT
cord-289034-yl3emjef	134	9	chronological	chronological	JJ
cord-289034-yl3emjef	134	10	sequence	sequence	NN
cord-289034-yl3emjef	134	11	of	of	IN
cord-289034-yl3emjef	134	12	molecular	molecular	JJ
cord-289034-yl3emjef	134	13	events	event	NNS
cord-289034-yl3emjef	134	14	involved	involve	VBN
cord-289034-yl3emjef	134	15	in	in	IN
cord-289034-yl3emjef	134	16	the	the	DT
cord-289034-yl3emjef	134	17	pathogenesis	pathogenesis	NN
cord-289034-yl3emjef	134	18	of	of	IN
cord-289034-yl3emjef	134	19	these	these	DT
cord-289034-yl3emjef	134	20	diseases	disease	NNS
cord-289034-yl3emjef	134	21	.	.	.
cord-289034-yl3emjef	135	1	Further	further	JJ
cord-289034-yl3emjef	135	2	investigations	investigation	NNS
cord-289034-yl3emjef	135	3	are	be	VBP
cord-289034-yl3emjef	135	4	also	also	RB
cord-289034-yl3emjef	135	5	needed	need	VBN
cord-289034-yl3emjef	135	6	to	to	TO
cord-289034-yl3emjef	135	7	assess	assess	VB
cord-289034-yl3emjef	135	8	whether	whether	IN
cord-289034-yl3emjef	135	9	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	135	10	dysfunction	dysfunction	NN
cord-289034-yl3emjef	135	11	represents	represent	VBZ
cord-289034-yl3emjef	135	12	a	a	DT
cord-289034-yl3emjef	135	13	primary	primary	JJ
cord-289034-yl3emjef	135	14	cause	cause	NN
cord-289034-yl3emjef	135	15	of	of	IN
cord-289034-yl3emjef	135	16	AD	ad	NN
cord-289034-yl3emjef	135	17	or	or	CC
cord-289034-yl3emjef	135	18	a	a	DT
cord-289034-yl3emjef	135	19	consequence	consequence	NN
cord-289034-yl3emjef	135	20	of	of	IN
cord-289034-yl3emjef	135	21	other	other	JJ
cord-289034-yl3emjef	135	22	molecular	molecular	JJ
cord-289034-yl3emjef	135	23	/	/	SYM
cord-289034-yl3emjef	135	24	genetic	genetic	JJ
cord-289034-yl3emjef	135	25	events	event	NNS
cord-289034-yl3emjef	135	26	.	.	.
cord-289034-yl3emjef	136	1	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	136	2	dysfunction	dysfunction	NN
cord-289034-yl3emjef	136	3	has	have	VBZ
cord-289034-yl3emjef	136	4	been	be	VBN
cord-289034-yl3emjef	136	5	involved	involve	VBN
cord-289034-yl3emjef	136	6	in	in	IN
cord-289034-yl3emjef	136	7	different	different	JJ
cord-289034-yl3emjef	136	8	aspects	aspect	NNS
cord-289034-yl3emjef	136	9	of	of	IN
cord-289034-yl3emjef	136	10	the	the	DT
cord-289034-yl3emjef	136	11	pathogenesis	pathogenesis	NN
cord-289034-yl3emjef	136	12	of	of	IN
cord-289034-yl3emjef	136	13	cancer	cancer	NN
cord-289034-yl3emjef	136	14	,	,	,
cord-289034-yl3emjef	136	15	from	from	IN
cord-289034-yl3emjef	136	16	the	the	DT
cord-289034-yl3emjef	136	17	early	early	JJ
cord-289034-yl3emjef	136	18	steps	step	NNS
cord-289034-yl3emjef	136	19	of	of	IN
cord-289034-yl3emjef	136	20	cancer	cancer	NN
cord-289034-yl3emjef	136	21	development	development	NN
cord-289034-yl3emjef	136	22	to	to	IN
cord-289034-yl3emjef	136	23	cancer	cancer	NN
cord-289034-yl3emjef	136	24	progression	progression	NN
cord-289034-yl3emjef	136	25	to	to	IN
cord-289034-yl3emjef	136	26	a	a	DT
cord-289034-yl3emjef	136	27	metastatic	metastatic	JJ
cord-289034-yl3emjef	136	28	phenotype	phenotype	NN
cord-289034-yl3emjef	136	29	,	,	,
cord-289034-yl3emjef	136	30	and	and	CC
cord-289034-yl3emjef	136	31	resistance	resistance	NN
cord-289034-yl3emjef	136	32	to	to	IN
cord-289034-yl3emjef	136	33	anti	anti	JJ
cord-289034-yl3emjef	136	34	-	-	JJ
cord-289034-yl3emjef	136	35	cancer	cancer	JJ
cord-289034-yl3emjef	136	36	drugs	drug	NNS
cord-289034-yl3emjef	136	37	[	[	-LRB-
cord-289034-yl3emjef	136	38	1	1	CD
cord-289034-yl3emjef	136	39	,	,	,
cord-289034-yl3emjef	136	40	19	19	CD
cord-289034-yl3emjef	136	41	,	,	,
cord-289034-yl3emjef	136	42	29	29	CD
cord-289034-yl3emjef	136	43	]	]	-RRB-
cord-289034-yl3emjef	136	44	.	.	.
cord-289034-yl3emjef	137	1	In	in	IN
cord-289034-yl3emjef	137	2	this	this	DT
cord-289034-yl3emjef	137	3	context	context	NN
cord-289034-yl3emjef	137	4	,	,	,
cord-289034-yl3emjef	137	5	mutations	mutation	NNS
cord-289034-yl3emjef	137	6	in	in	IN
cord-289034-yl3emjef	137	7	three	three	CD
cord-289034-yl3emjef	137	8	TCA	TCA	NNP
cord-289034-yl3emjef	137	9	cycle	cycle	NN
cord-289034-yl3emjef	137	10	enzymes	enzyme	NNS
cord-289034-yl3emjef	137	11	,	,	,
cord-289034-yl3emjef	137	12	namely	namely	RB
cord-289034-yl3emjef	137	13	succinate	succinate	NN
cord-289034-yl3emjef	137	14	dehydrogenase	dehydrogenase	NN
cord-289034-yl3emjef	137	15	,	,	,
cord-289034-yl3emjef	137	16	fumarate	fumarate	NNP
cord-289034-yl3emjef	137	17	hydratase	hydratase	NNP
cord-289034-yl3emjef	137	18	and	and	CC
cord-289034-yl3emjef	137	19	isocitrate	isocitrate	NNP
cord-289034-yl3emjef	137	20	dehydrogenase	dehydrogenase	NN
cord-289034-yl3emjef	137	21	,	,	,
cord-289034-yl3emjef	137	22	have	have	VBP
cord-289034-yl3emjef	137	23	been	be	VBN
cord-289034-yl3emjef	137	24	shown	show	VBN
cord-289034-yl3emjef	137	25	to	to	TO
cord-289034-yl3emjef	137	26	play	play	VB
cord-289034-yl3emjef	137	27	a	a	DT
cord-289034-yl3emjef	137	28	causal	causal	JJ
cord-289034-yl3emjef	137	29	role	role	NN
cord-289034-yl3emjef	137	30	in	in	IN
cord-289034-yl3emjef	137	31	carcinogenesis	carcinogenesis	NN
cord-289034-yl3emjef	137	32	[	[	-LRB-
cord-289034-yl3emjef	137	33	54	54	CD
cord-289034-yl3emjef	137	34	,	,	,
cord-289034-yl3emjef	137	35	55	55	CD
cord-289034-yl3emjef	137	36	]	]	-RRB-
cord-289034-yl3emjef	137	37	,	,	,
cord-289034-yl3emjef	137	38	thus	thus	RB
cord-289034-yl3emjef	137	39	providing	provide	VBG
cord-289034-yl3emjef	137	40	compelling	compelling	JJ
cord-289034-yl3emjef	137	41	evidence	evidence	NN
cord-289034-yl3emjef	137	42	for	for	IN
cord-289034-yl3emjef	137	43	the	the	DT
cord-289034-yl3emjef	137	44	involvement	involvement	NN
cord-289034-yl3emjef	137	45	of	of	IN
cord-289034-yl3emjef	137	46	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	137	47	metabolic	metabolic	JJ
cord-289034-yl3emjef	137	48	alterations	alteration	NNS
cord-289034-yl3emjef	137	49	as	as	IN
cord-289034-yl3emjef	137	50	cancer	cancer	NN
cord-289034-yl3emjef	137	51	drivers	driver	NNS
cord-289034-yl3emjef	137	52	.	.	.
cord-289034-yl3emjef	138	1	Indeed	indeed	RB
cord-289034-yl3emjef	138	2	,	,	,
cord-289034-yl3emjef	138	3	mutations	mutation	NNS
cord-289034-yl3emjef	138	4	in	in	IN
cord-289034-yl3emjef	138	5	succinate	succinate	NN
cord-289034-yl3emjef	138	6	dehydrogenase	dehydrogenase	NN
cord-289034-yl3emjef	138	7	predispose	predispose	VB
cord-289034-yl3emjef	138	8	to	to	IN
cord-289034-yl3emjef	138	9	hereditary	hereditary	JJ
cord-289034-yl3emjef	138	10	paragangliomas	paragangliomas	NN
cord-289034-yl3emjef	138	11	,	,	,
cord-289034-yl3emjef	138	12	pheochromocytomas	pheochromocytomas	NNP
cord-289034-yl3emjef	138	13	,	,	,
cord-289034-yl3emjef	138	14	neuroblastomas	neuroblastomas	NNP
cord-289034-yl3emjef	138	15	,	,	,
cord-289034-yl3emjef	138	16	gastrointestinal	gastrointestinal	JJ
cord-289034-yl3emjef	138	17	tumors	tumor	NNS
cord-289034-yl3emjef	138	18	,	,	,
cord-289034-yl3emjef	138	19	renal	renal	JJ
cord-289034-yl3emjef	138	20	cell	cell	NN
cord-289034-yl3emjef	138	21	cancers	cancer	NNS
cord-289034-yl3emjef	138	22	and	and	CC
cord-289034-yl3emjef	138	23	thyroid	thyroid	NN
cord-289034-yl3emjef	138	24	tumors	tumor	NNS
cord-289034-yl3emjef	138	25	[	[	-LRB-
cord-289034-yl3emjef	138	26	54	54	CD
cord-289034-yl3emjef	138	27	]	]	-RRB-
cord-289034-yl3emjef	138	28	.	.	.
cord-289034-yl3emjef	139	1	Sporadic	sporadic	JJ
cord-289034-yl3emjef	139	2	and	and	CC
cord-289034-yl3emjef	139	3	hereditary	hereditary	JJ
cord-289034-yl3emjef	139	4	mutations	mutation	NNS
cord-289034-yl3emjef	139	5	of	of	IN
cord-289034-yl3emjef	139	6	fumarate	fumarate	NNP
cord-289034-yl3emjef	139	7	hydratase	hydratase	NNP
cord-289034-yl3emjef	139	8	trigger	trigger	NN
cord-289034-yl3emjef	139	9	accumulation	accumulation	NN
cord-289034-yl3emjef	139	10	of	of	IN
cord-289034-yl3emjef	139	11	an	an	DT
cord-289034-yl3emjef	139	12	oncogenic	oncogenic	JJ
cord-289034-yl3emjef	139	13	metabolite	metabolite	NN
cord-289034-yl3emjef	139	14	,	,	,
cord-289034-yl3emjef	139	15	i.e.	i.e.	FW
cord-289034-yl3emjef	139	16	,	,	,
cord-289034-yl3emjef	139	17	fumarate	fumarate	NN
cord-289034-yl3emjef	139	18	,	,	,
cord-289034-yl3emjef	139	19	that	that	WDT
cord-289034-yl3emjef	139	20	favors	favor	VBZ
cord-289034-yl3emjef	139	21	development	development	NN
cord-289034-yl3emjef	139	22	of	of	IN
cord-289034-yl3emjef	139	23	hereditary	hereditary	JJ
cord-289034-yl3emjef	139	24	leiomyomatosis	leiomyomatosis	NN
cord-289034-yl3emjef	139	25	and	and	CC
cord-289034-yl3emjef	139	26	renal	renal	JJ
cord-289034-yl3emjef	139	27	cell	cell	NN
cord-289034-yl3emjef	139	28	carcinoma	carcinoma	NN
cord-289034-yl3emjef	139	29	,	,	,
cord-289034-yl3emjef	139	30	Ewing	Ewing	NNP
cord-289034-yl3emjef	139	31	sarcoma	sarcoma	NN
cord-289034-yl3emjef	139	32	and	and	CC
cord-289034-yl3emjef	139	33	osteosarcoma	osteosarcoma	NN
cord-289034-yl3emjef	139	34	,	,	,
cord-289034-yl3emjef	139	35	adrenocortical	adrenocortical	JJ
cord-289034-yl3emjef	139	36	carcinoma	carcinoma	NN
cord-289034-yl3emjef	139	37	,	,	,
cord-289034-yl3emjef	139	38	pheochromocytoma	pheochromocytoma	NN
cord-289034-yl3emjef	139	39	,	,	,
cord-289034-yl3emjef	139	40	glioma	glioma	NN
cord-289034-yl3emjef	139	41	,	,	,
cord-289034-yl3emjef	139	42	neuroblastoma	neuroblastoma	NN
cord-289034-yl3emjef	139	43	,	,	,
cord-289034-yl3emjef	139	44	paraganglioma	paraganglioma	NN
cord-289034-yl3emjef	139	45	,	,	,
cord-289034-yl3emjef	139	46	and	and	CC
cord-289034-yl3emjef	139	47	ependymoma	ependymoma	NNP
cord-289034-yl3emjef	139	48	[	[	-LRB-
cord-289034-yl3emjef	139	49	55	55	CD
cord-289034-yl3emjef	139	50	]	]	-RRB-
cord-289034-yl3emjef	139	51	.	.	.
cord-289034-yl3emjef	140	1	Mutations	mutation	NNS
cord-289034-yl3emjef	140	2	in	in	IN
cord-289034-yl3emjef	140	3	isocitrate	isocitrate	JJ
cord-289034-yl3emjef	140	4	dehydrogenase	dehydrogenase	NN
cord-289034-yl3emjef	140	5	are	be	VBP
cord-289034-yl3emjef	140	6	only	only	RB
cord-289034-yl3emjef	140	7	somatic	somatic	JJ
cord-289034-yl3emjef	140	8	and	and	CC
cord-289034-yl3emjef	140	9	have	have	VBP
cord-289034-yl3emjef	140	10	been	be	VBN
cord-289034-yl3emjef	140	11	detected	detect	VBN
cord-289034-yl3emjef	140	12	in	in	IN
cord-289034-yl3emjef	140	13	about	about	RB
cord-289034-yl3emjef	140	14	20	20	CD
cord-289034-yl3emjef	140	15	%	%	NN
cord-289034-yl3emjef	140	16	of	of	IN
cord-289034-yl3emjef	140	17	patients	patient	NNS
cord-289034-yl3emjef	140	18	with	with	IN
cord-289034-yl3emjef	140	19	acute	acute	JJ
cord-289034-yl3emjef	140	20	myeloid	myeloid	JJ
cord-289034-yl3emjef	140	21	leukemia	leukemia	NN
cord-289034-yl3emjef	140	22	or	or	CC
cord-289034-yl3emjef	140	23	angioimmunoblastic	angioimmunoblastic	JJ
cord-289034-yl3emjef	140	24	T	t	NN
cord-289034-yl3emjef	140	25	-	-	HYPH
cord-289034-yl3emjef	140	26	cell	cell	NN
cord-289034-yl3emjef	140	27	lymphoma	lymphoma	NN
cord-289034-yl3emjef	140	28	,	,	,
cord-289034-yl3emjef	140	29	and	and	CC
cord-289034-yl3emjef	140	30	at	at	IN
cord-289034-yl3emjef	140	31	lower	low	JJR
cord-289034-yl3emjef	140	32	frequencies	frequency	NNS
cord-289034-yl3emjef	140	33	in	in	IN
cord-289034-yl3emjef	140	34	patients	patient	NNS
cord-289034-yl3emjef	140	35	with	with	IN
cord-289034-yl3emjef	140	36	thyroid	thyroid	NN
cord-289034-yl3emjef	140	37	,	,	,
cord-289034-yl3emjef	140	38	prostate	prostate	NN
cord-289034-yl3emjef	140	39	,	,	,
cord-289034-yl3emjef	140	40	colorectal	colorectal	JJ
cord-289034-yl3emjef	140	41	cancer	cancer	NN
cord-289034-yl3emjef	140	42	and	and	CC
cord-289034-yl3emjef	140	43	B	b	NN
cord-289034-yl3emjef	140	44	-	-	HYPH
cord-289034-yl3emjef	140	45	cell	cell	NN
cord-289034-yl3emjef	140	46	acute	acute	JJ
cord-289034-yl3emjef	140	47	lymphoblastic	lymphoblastic	JJ
cord-289034-yl3emjef	140	48	leukemia	leukemia	NN
cord-289034-yl3emjef	140	49	[	[	-LRB-
cord-289034-yl3emjef	140	50	54	54	CD
cord-289034-yl3emjef	140	51	,	,	,
cord-289034-yl3emjef	140	52	56	56	CD
cord-289034-yl3emjef	140	53	]	]	-RRB-
cord-289034-yl3emjef	140	54	.	.	.
cord-289034-yl3emjef	141	1	Besides	besides	IN
cord-289034-yl3emjef	141	2	mutations	mutation	NNS
cord-289034-yl3emjef	141	3	in	in	IN
cord-289034-yl3emjef	141	4	nuclear	nuclear	NN
cord-289034-yl3emjef	141	5	-	-	HYPH
cord-289034-yl3emjef	141	6	encoded	encode	VBN
cord-289034-yl3emjef	141	7	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	141	8	proteins	protein	NNS
cord-289034-yl3emjef	141	9	,	,	,
cord-289034-yl3emjef	141	10	mutations	mutation	NNS
cord-289034-yl3emjef	141	11	in	in	IN
cord-289034-yl3emjef	141	12	mtDNA	mtdna	NN
cord-289034-yl3emjef	141	13	-	-	HYPH
cord-289034-yl3emjef	141	14	encoded	encode	VBN
cord-289034-yl3emjef	141	15	proteins	protein	NNS
cord-289034-yl3emjef	141	16	have	have	VBP
cord-289034-yl3emjef	141	17	also	also	RB
cord-289034-yl3emjef	141	18	been	be	VBN
cord-289034-yl3emjef	141	19	implicated	implicate	VBN
cord-289034-yl3emjef	141	20	in	in	IN
cord-289034-yl3emjef	141	21	the	the	DT
cord-289034-yl3emjef	141	22	pathogenesis	pathogenesis	NN
cord-289034-yl3emjef	141	23	of	of	IN
cord-289034-yl3emjef	141	24	cancer	cancer	NN
cord-289034-yl3emjef	141	25	.	.	.
cord-289034-yl3emjef	142	1	The	the	DT
cord-289034-yl3emjef	142	2	spectrum	spectrum	NN
cord-289034-yl3emjef	142	3	of	of	IN
cord-289034-yl3emjef	142	4	somatic	somatic	JJ
cord-289034-yl3emjef	142	5	mtDNA	mtdna	NN
cord-289034-yl3emjef	142	6	mutations	mutation	NNS
cord-289034-yl3emjef	142	7	varies	vary	VBZ
cord-289034-yl3emjef	142	8	among	among	IN
cord-289034-yl3emjef	142	9	different	different	JJ
cord-289034-yl3emjef	142	10	tissues	tissue	NNS
cord-289034-yl3emjef	142	11	,	,	,
cord-289034-yl3emjef	142	12	and	and	CC
cord-289034-yl3emjef	142	13	increasing	increase	VBG
cord-289034-yl3emjef	142	14	evidence	evidence	NN
cord-289034-yl3emjef	142	15	shows	show	VBZ
cord-289034-yl3emjef	142	16	that	that	IN
cord-289034-yl3emjef	142	17	the	the	DT
cord-289034-yl3emjef	142	18	load	load	NN
cord-289034-yl3emjef	142	19	of	of	IN
cord-289034-yl3emjef	142	20	mtDNA	mtdna	NN
cord-289034-yl3emjef	142	21	mutations	mutation	NNS
cord-289034-yl3emjef	142	22	could	could	MD
cord-289034-yl3emjef	142	23	have	have	VB
cord-289034-yl3emjef	142	24	prognostic	prognostic	JJ
cord-289034-yl3emjef	142	25	value	value	NN
cord-289034-yl3emjef	142	26	.	.	.
cord-289034-yl3emjef	143	1	The	the	DT
cord-289034-yl3emjef	143	2	majority	majority	NN
cord-289034-yl3emjef	143	3	of	of	IN
cord-289034-yl3emjef	143	4	cancer	cancer	NN
cord-289034-yl3emjef	143	5	-	-	HYPH
cord-289034-yl3emjef	143	6	related	relate	VBN
cord-289034-yl3emjef	143	7	mtDNA	mtdna	NN
cord-289034-yl3emjef	143	8	mutations	mutation	NNS
cord-289034-yl3emjef	143	9	have	have	VBP
cord-289034-yl3emjef	143	10	been	be	VBN
cord-289034-yl3emjef	143	11	found	find	VBN
cord-289034-yl3emjef	143	12	in	in	IN
cord-289034-yl3emjef	143	13	prostate	prostate	NN
cord-289034-yl3emjef	143	14	cancer	cancer	NN
cord-289034-yl3emjef	143	15	,	,	,
cord-289034-yl3emjef	143	16	with	with	IN
cord-289034-yl3emjef	143	17	a	a	DT
cord-289034-yl3emjef	143	18	total	total	NN
cord-289034-yl3emjef	143	19	of	of	IN
cord-289034-yl3emjef	143	20	more	more	JJR
cord-289034-yl3emjef	143	21	than	than	IN
cord-289034-yl3emjef	143	22	700	700	CD
cord-289034-yl3emjef	143	23	unique	unique	JJ
cord-289034-yl3emjef	143	24	somatic	somatic	JJ
cord-289034-yl3emjef	143	25	mtDNA	mtdna	NN
cord-289034-yl3emjef	143	26	mutations	mutation	NNS
cord-289034-yl3emjef	143	27	associated	associate	VBN
cord-289034-yl3emjef	143	28	with	with	IN
cord-289034-yl3emjef	143	29	this	this	DT
cord-289034-yl3emjef	143	30	cancer	cancer	NN
cord-289034-yl3emjef	143	31	[	[	-LRB-
cord-289034-yl3emjef	143	32	57	57	CD
cord-289034-yl3emjef	143	33	]	]	-RRB-
cord-289034-yl3emjef	143	34	.	.	.
cord-289034-yl3emjef	144	1	There	there	EX
cord-289034-yl3emjef	144	2	is	be	VBZ
cord-289034-yl3emjef	144	3	increasing	increase	VBG
cord-289034-yl3emjef	144	4	evidence	evidence	NN
cord-289034-yl3emjef	144	5	that	that	IN
cord-289034-yl3emjef	144	6	mtDNA	mtDNA	NNP
cord-289034-yl3emjef	144	7	mutations	mutation	NNS
cord-289034-yl3emjef	144	8	/	/	SYM
cord-289034-yl3emjef	144	9	depletion	depletion	NN
cord-289034-yl3emjef	144	10	may	may	MD
cord-289034-yl3emjef	144	11	favor	favor	VB
cord-289034-yl3emjef	144	12	cancer	cancer	NN
cord-289034-yl3emjef	144	13	progression	progression	NN
cord-289034-yl3emjef	144	14	to	to	IN
cord-289034-yl3emjef	144	15	a	a	DT
cord-289034-yl3emjef	144	16	metastatic	metastatic	JJ
cord-289034-yl3emjef	144	17	and	and	CC
cord-289034-yl3emjef	144	18	drug	drug	NN
cord-289034-yl3emjef	144	19	-	-	HYPH
cord-289034-yl3emjef	144	20	resistant	resistant	JJ
cord-289034-yl3emjef	144	21	phenotype	phenotype	NN
cord-289034-yl3emjef	144	22	through	through	IN
cord-289034-yl3emjef	144	23	increased	increase	VBN
cord-289034-yl3emjef	144	24	production	production	NN
cord-289034-yl3emjef	144	25	of	of	IN
cord-289034-yl3emjef	144	26	ROS	ROS	NNP
cord-289034-yl3emjef	144	27	and/or	and/or	CC
cord-289034-yl3emjef	144	28	activation	activation	NN
cord-289034-yl3emjef	144	29	of	of	IN
cord-289034-yl3emjef	144	30	a	a	DT
cord-289034-yl3emjef	144	31	mitochondria	mitochondria	NN
cord-289034-yl3emjef	144	32	-	-	HYPH
cord-289034-yl3emjef	144	33	to	to	IN
cord-289034-yl3emjef	144	34	-	-	HYPH
cord-289034-yl3emjef	144	35	nucleus	nucleus	NN
cord-289034-yl3emjef	144	36	signaling	signaling	NN
cord-289034-yl3emjef	144	37	that	that	WDT
cord-289034-yl3emjef	144	38	leads	lead	VBZ
cord-289034-yl3emjef	144	39	to	to	IN
cord-289034-yl3emjef	144	40	expression	expression	NN
cord-289034-yl3emjef	144	41	of	of	IN
cord-289034-yl3emjef	144	42	pro	pro	JJ
cord-289034-yl3emjef	144	43	-	-	JJ
cord-289034-yl3emjef	144	44	metastatic	metastatic	JJ
cord-289034-yl3emjef	144	45	and	and	CC
cord-289034-yl3emjef	144	46	pro	pro	JJ
cord-289034-yl3emjef	144	47	-	-	JJ
cord-289034-yl3emjef	144	48	survival	survival	JJ
cord-289034-yl3emjef	144	49	nuclear	nuclear	JJ
cord-289034-yl3emjef	144	50	genes	gene	NNS
cord-289034-yl3emjef	144	51	[	[	-LRB-
cord-289034-yl3emjef	144	52	20	20	CD
cord-289034-yl3emjef	144	53	,	,	,
cord-289034-yl3emjef	144	54	29	29	CD
cord-289034-yl3emjef	144	55	,	,	,
cord-289034-yl3emjef	144	56	[	[	-LRB-
cord-289034-yl3emjef	144	57	58	58	CD
cord-289034-yl3emjef	144	58	]	]	-RRB-
cord-289034-yl3emjef	144	59	[	[	-LRB-
cord-289034-yl3emjef	144	60	59	59	CD
cord-289034-yl3emjef	144	61	]	]	-RRB-
cord-289034-yl3emjef	144	62	[	[	-LRB-
cord-289034-yl3emjef	144	63	60	60	CD
cord-289034-yl3emjef	144	64	]	]	-RRB-
cord-289034-yl3emjef	144	65	.	.	.
cord-289034-yl3emjef	145	1	Although	although	IN
cord-289034-yl3emjef	145	2	mtDNA	mtdna	JJ
cord-289034-yl3emjef	145	3	damage	damage	NN
cord-289034-yl3emjef	145	4	may	may	MD
cord-289034-yl3emjef	145	5	not	not	RB
cord-289034-yl3emjef	145	6	be	be	VB
cord-289034-yl3emjef	145	7	the	the	DT
cord-289034-yl3emjef	145	8	first	first	JJ
cord-289034-yl3emjef	145	9	driver	driver	NN
cord-289034-yl3emjef	145	10	of	of	IN
cord-289034-yl3emjef	145	11	cancer	cancer	NN
cord-289034-yl3emjef	145	12	progression	progression	NN
cord-289034-yl3emjef	145	13	,	,	,
cord-289034-yl3emjef	145	14	it	-PRON-	PRP
cord-289034-yl3emjef	145	15	is	be	VBZ
cord-289034-yl3emjef	145	16	likely	likely	JJ
cord-289034-yl3emjef	145	17	that	that	IN
cord-289034-yl3emjef	145	18	it	-PRON-	PRP
cord-289034-yl3emjef	145	19	represents	represent	VBZ
cord-289034-yl3emjef	145	20	a	a	DT
cord-289034-yl3emjef	145	21	"	"	``
cord-289034-yl3emjef	145	22	supporter	supporter	NN
cord-289034-yl3emjef	145	23	"	"	''
cord-289034-yl3emjef	145	24	event	event	NN
cord-289034-yl3emjef	145	25	that	that	WDT
cord-289034-yl3emjef	145	26	facilitates	facilitate	VBZ
cord-289034-yl3emjef	145	27	and	and	CC
cord-289034-yl3emjef	145	28	accelerates	accelerate	VBZ
cord-289034-yl3emjef	145	29	different	different	JJ
cord-289034-yl3emjef	145	30	steps	step	NNS
cord-289034-yl3emjef	145	31	of	of	IN
cord-289034-yl3emjef	145	32	the	the	DT
cord-289034-yl3emjef	145	33	metastatic	metastatic	JJ
cord-289034-yl3emjef	145	34	cascade	cascade	NN
cord-289034-yl3emjef	145	35	,	,	,
cord-289034-yl3emjef	145	36	probably	probably	RB
cord-289034-yl3emjef	145	37	within	within	IN
cord-289034-yl3emjef	145	38	a	a	DT
cord-289034-yl3emjef	145	39	precise	precise	JJ
cord-289034-yl3emjef	145	40	time	time	NN
cord-289034-yl3emjef	145	41	window	window	NN
cord-289034-yl3emjef	145	42	that	that	WDT
cord-289034-yl3emjef	145	43	remains	remain	VBZ
cord-289034-yl3emjef	145	44	to	to	TO
cord-289034-yl3emjef	145	45	be	be	VB
cord-289034-yl3emjef	145	46	identified	identify	VBN
cord-289034-yl3emjef	145	47	.	.	.
cord-289034-yl3emjef	146	1	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	146	2	dysfunction	dysfunction	NN
cord-289034-yl3emjef	146	3	is	be	VBZ
cord-289034-yl3emjef	146	4	implicated	implicate	VBN
cord-289034-yl3emjef	146	5	in	in	IN
cord-289034-yl3emjef	146	6	several	several	JJ
cord-289034-yl3emjef	146	7	pathological	pathological	JJ
cord-289034-yl3emjef	146	8	conditions	condition	NNS
cord-289034-yl3emjef	146	9	,	,	,
cord-289034-yl3emjef	146	10	ranging	range	VBG
cord-289034-yl3emjef	146	11	from	from	IN
cord-289034-yl3emjef	146	12	neurodegenerative	neurodegenerative	JJ
cord-289034-yl3emjef	146	13	and	and	CC
cord-289034-yl3emjef	146	14	cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	146	15	diseases	disease	NNS
cord-289034-yl3emjef	146	16	,	,	,
cord-289034-yl3emjef	146	17	to	to	IN
cord-289034-yl3emjef	146	18	aging	age	VBG
cord-289034-yl3emjef	146	19	,	,	,
cord-289034-yl3emjef	146	20	cancer	cancer	NN
cord-289034-yl3emjef	146	21	and	and	CC
cord-289034-yl3emjef	146	22	inflammation	inflammation	NN
cord-289034-yl3emjef	146	23	.	.	.
cord-289034-yl3emjef	147	1	Each	each	DT
cord-289034-yl3emjef	147	2	of	of	IN
cord-289034-yl3emjef	147	3	these	these	DT
cord-289034-yl3emjef	147	4	conditions	condition	NNS
cord-289034-yl3emjef	147	5	shows	show	VBZ
cord-289034-yl3emjef	147	6	a	a	DT
cord-289034-yl3emjef	147	7	peculiar	peculiar	JJ
cord-289034-yl3emjef	147	8	involvement	involvement	NN
cord-289034-yl3emjef	147	9	of	of	IN
cord-289034-yl3emjef	147	10	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	147	11	.	.	.
cord-289034-yl3emjef	148	1	For	for	IN
cord-289034-yl3emjef	148	2	example	example	NN
cord-289034-yl3emjef	148	3	,	,	,
cord-289034-yl3emjef	148	4	up	up	IN
cord-289034-yl3emjef	148	5	to	to	TO
cord-289034-yl3emjef	148	6	94	94	CD
cord-289034-yl3emjef	148	7	%	%	NN
cord-289034-yl3emjef	148	8	of	of	IN
cord-289034-yl3emjef	148	9	PD	PD	NNP
cord-289034-yl3emjef	148	10	patients	patient	NNS
cord-289034-yl3emjef	148	11	show	show	VBP
cord-289034-yl3emjef	148	12	a	a	DT
cord-289034-yl3emjef	148	13	defect	defect	NN
cord-289034-yl3emjef	148	14	in	in	IN
cord-289034-yl3emjef	148	15	Miro1	miro1	JJ
cord-289034-yl3emjef	148	16	function	function	NN
cord-289034-yl3emjef	148	17	,	,	,
cord-289034-yl3emjef	148	18	because	because	IN
cord-289034-yl3emjef	148	19	this	this	DT
cord-289034-yl3emjef	148	20	protein	protein	NN
cord-289034-yl3emjef	148	21	,	,	,
cord-289034-yl3emjef	148	22	located	locate	VBN
cord-289034-yl3emjef	148	23	on	on	IN
cord-289034-yl3emjef	148	24	the	the	DT
cord-289034-yl3emjef	148	25	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	148	26	surface	surface	NN
cord-289034-yl3emjef	148	27	,	,	,
cord-289034-yl3emjef	148	28	fails	fail	VBZ
cord-289034-yl3emjef	148	29	to	to	TO
cord-289034-yl3emjef	148	30	detach	detach	VB
cord-289034-yl3emjef	148	31	from	from	IN
cord-289034-yl3emjef	148	32	depolarized	depolarize	VBN
cord-289034-yl3emjef	148	33	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	148	34	resulting	result	VBG
cord-289034-yl3emjef	148	35	in	in	IN
cord-289034-yl3emjef	148	36	defective	defective	JJ
cord-289034-yl3emjef	148	37	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	148	38	locomotion	locomotion	NN
cord-289034-yl3emjef	148	39	and	and	CC
cord-289034-yl3emjef	148	40	clearance	clearance	NN
cord-289034-yl3emjef	148	41	by	by	IN
cord-289034-yl3emjef	148	42	mitophagy	mitophagy	NNP
cord-289034-yl3emjef	148	43	[	[	-LRB-
cord-289034-yl3emjef	148	44	61	61	CD
cord-289034-yl3emjef	148	45	]	]	-RRB-
cord-289034-yl3emjef	148	46	.	.	.
cord-289034-yl3emjef	149	1	These	these	DT
cord-289034-yl3emjef	149	2	new	new	JJ
cord-289034-yl3emjef	149	3	results	result	NNS
cord-289034-yl3emjef	149	4	suggest	suggest	VBP
cord-289034-yl3emjef	149	5	that	that	IN
cord-289034-yl3emjef	149	6	Miro1-based	Miro1-based	NNP
cord-289034-yl3emjef	149	7	therapeutic	therapeutic	JJ
cord-289034-yl3emjef	149	8	strategies	strategy	NNS
cord-289034-yl3emjef	149	9	may	may	MD
cord-289034-yl3emjef	149	10	provide	provide	VB
cord-289034-yl3emjef	149	11	new	new	JJ
cord-289034-yl3emjef	149	12	avenues	avenue	NNS
cord-289034-yl3emjef	149	13	to	to	IN
cord-289034-yl3emjef	149	14	a	a	DT
cord-289034-yl3emjef	149	15	personalized	personalized	JJ
cord-289034-yl3emjef	149	16	medicine	medicine	NN
cord-289034-yl3emjef	149	17	for	for	IN
cord-289034-yl3emjef	149	18	PD	PD	NNP
cord-289034-yl3emjef	149	19	.	.	.
cord-289034-yl3emjef	150	1	The	the	DT
cord-289034-yl3emjef	150	2	role	role	NN
cord-289034-yl3emjef	150	3	of	of	IN
cord-289034-yl3emjef	150	4	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	150	5	dysfunction	dysfunction	NN
cord-289034-yl3emjef	150	6	in	in	IN
cord-289034-yl3emjef	150	7	other	other	JJ
cord-289034-yl3emjef	150	8	diseases	disease	NNS
cord-289034-yl3emjef	150	9	is	be	VBZ
cord-289034-yl3emjef	150	10	still	still	RB
cord-289034-yl3emjef	150	11	somehow	somehow	RB
cord-289034-yl3emjef	150	12	controversial	controversial	JJ
cord-289034-yl3emjef	150	13	.	.	.
cord-289034-yl3emjef	151	1	In	in	IN
cord-289034-yl3emjef	151	2	some	some	DT
cord-289034-yl3emjef	151	3	cases	case	NNS
cord-289034-yl3emjef	151	4	,	,	,
cord-289034-yl3emjef	151	5	it	-PRON-	PRP
cord-289034-yl3emjef	151	6	may	may	MD
cord-289034-yl3emjef	151	7	represent	represent	VB
cord-289034-yl3emjef	151	8	a	a	DT
cord-289034-yl3emjef	151	9	driver	driver	NN
cord-289034-yl3emjef	151	10	event	event	NN
cord-289034-yl3emjef	151	11	,	,	,
cord-289034-yl3emjef	151	12	like	like	IN
cord-289034-yl3emjef	151	13	for	for	IN
cord-289034-yl3emjef	151	14	mutations	mutation	NNS
cord-289034-yl3emjef	151	15	in	in	IN
cord-289034-yl3emjef	151	16	the	the	DT
cord-289034-yl3emjef	151	17	TCA	TCA	NNP
cord-289034-yl3emjef	151	18	cycle	cycle	NN
cord-289034-yl3emjef	151	19	enzymes	enzyme	NNS
cord-289034-yl3emjef	151	20	succinate	succinate	NN
cord-289034-yl3emjef	151	21	dehydrogenase	dehydrogenase	NN
cord-289034-yl3emjef	151	22	,	,	,
cord-289034-yl3emjef	151	23	fumarate	fumarate	NNP
cord-289034-yl3emjef	151	24	hydratase	hydratase	NNP
cord-289034-yl3emjef	151	25	and	and	CC
cord-289034-yl3emjef	151	26	isocitrate	isocitrate	JJ
cord-289034-yl3emjef	151	27	dehydrogenase	dehydrogenase	NN
cord-289034-yl3emjef	151	28	that	that	WDT
cord-289034-yl3emjef	151	29	predispose	predispose	VBP
cord-289034-yl3emjef	151	30	to	to	IN
cord-289034-yl3emjef	151	31	certain	certain	JJ
cord-289034-yl3emjef	151	32	types	type	NNS
cord-289034-yl3emjef	151	33	of	of	IN
cord-289034-yl3emjef	151	34	tumors	tumor	NNS
cord-289034-yl3emjef	151	35	.	.	.
cord-289034-yl3emjef	152	1	In	in	IN
cord-289034-yl3emjef	152	2	other	other	JJ
cord-289034-yl3emjef	152	3	cases	case	NNS
cord-289034-yl3emjef	152	4	,	,	,
cord-289034-yl3emjef	152	5	a	a	DT
cord-289034-yl3emjef	152	6	transient	transient	JJ
cord-289034-yl3emjef	152	7	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	152	8	dysfunction	dysfunction	NN
cord-289034-yl3emjef	152	9	may	may	MD
cord-289034-yl3emjef	152	10	support	support	VB
cord-289034-yl3emjef	152	11	a	a	DT
cord-289034-yl3emjef	152	12	metabolic	metabolic	JJ
cord-289034-yl3emjef	152	13	rewiring	rewiring	NN
cord-289034-yl3emjef	152	14	needed	need	VBN
cord-289034-yl3emjef	152	15	by	by	IN
cord-289034-yl3emjef	152	16	the	the	DT
cord-289034-yl3emjef	152	17	cells	cell	NNS
cord-289034-yl3emjef	152	18	to	to	TO
cord-289034-yl3emjef	152	19	adapt	adapt	VB
cord-289034-yl3emjef	152	20	and	and	CC
cord-289034-yl3emjef	152	21	survive	survive	VB
cord-289034-yl3emjef	152	22	to	to	TO
cord-289034-yl3emjef	152	23	microenvironmental	microenvironmental	VB
cord-289034-yl3emjef	152	24	stressors	stressor	NNS
cord-289034-yl3emjef	152	25	.	.	.
cord-289034-yl3emjef	153	1	The	the	DT
cord-289034-yl3emjef	153	2	author	author	NN
cord-289034-yl3emjef	153	3	declares	declare	VBZ
cord-289034-yl3emjef	153	4	no	no	DT
cord-289034-yl3emjef	153	5	conflict	conflict	NN
cord-289034-yl3emjef	153	6	of	of	IN
cord-289034-yl3emjef	153	7	interest	interest	NN
cord-289034-yl3emjef	153	8	.	.	.
cord-289034-yl3emjef	154	1	How	how	WRB
cord-289034-yl3emjef	154	2	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	154	3	produce	produce	VBP
cord-289034-yl3emjef	154	4	reactive	reactive	JJ
cord-289034-yl3emjef	154	5	oxygen	oxygen	NN
cord-289034-yl3emjef	154	6	species	specie	NNS
cord-289034-yl3emjef	155	1	The	the	DT
cord-289034-yl3emjef	155	2	role	role	NN
cord-289034-yl3emjef	155	3	of	of	IN
cord-289034-yl3emjef	155	4	the	the	DT
cord-289034-yl3emjef	155	5	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	155	6	permeability	permeability	NN
cord-289034-yl3emjef	155	7	transition	transition	NN
cord-289034-yl3emjef	155	8	pore	pore	NN
cord-289034-yl3emjef	155	9	in	in	IN
cord-289034-yl3emjef	155	10	heart	heart	NN
cord-289034-yl3emjef	155	11	disease	disease	NN
cord-289034-yl3emjef	155	12	Regulation	regulation	NN
cord-289034-yl3emjef	155	13	of	of	IN
cord-289034-yl3emjef	155	14	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	155	15	biogenesis	biogenesis	NN
cord-289034-yl3emjef	155	16	Mitochondrial	mitochondrial	IN
cord-289034-yl3emjef	155	17	quality	quality	NN
cord-289034-yl3emjef	155	18	control	control	NN
cord-289034-yl3emjef	155	19	in	in	IN
cord-289034-yl3emjef	155	20	cardiac	cardiac	JJ
cord-289034-yl3emjef	155	21	cells	cell	NNS
cord-289034-yl3emjef	155	22	:	:	:
cord-289034-yl3emjef	155	23	Mechanisms	mechanism	NNS
cord-289034-yl3emjef	155	24	and	and	CC
cord-289034-yl3emjef	155	25	role	role	NN
cord-289034-yl3emjef	155	26	in	in	IN
cord-289034-yl3emjef	155	27	cardiac	cardiac	JJ
cord-289034-yl3emjef	155	28	cell	cell	NN
cord-289034-yl3emjef	155	29	injury	injury	NN
cord-289034-yl3emjef	155	30	and	and	CC
cord-289034-yl3emjef	155	31	disease	disease	NN
cord-289034-yl3emjef	155	32	Intersection	intersection	NN
cord-289034-yl3emjef	155	33	of	of	IN
cord-289034-yl3emjef	155	34	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	155	35	fission	fission	NN
cord-289034-yl3emjef	155	36	and	and	CC
cord-289034-yl3emjef	155	37	fusion	fusion	NN
cord-289034-yl3emjef	155	38	machinery	machinery	NN
cord-289034-yl3emjef	155	39	with	with	IN
cord-289034-yl3emjef	155	40	apoptotic	apoptotic	JJ
cord-289034-yl3emjef	155	41	pathways	pathway	NNS
cord-289034-yl3emjef	155	42	:	:	:
cord-289034-yl3emjef	155	43	Role	role	NN
cord-289034-yl3emjef	155	44	of	of	IN
cord-289034-yl3emjef	155	45	Mcl-1	Mcl-1	NNP
cord-289034-yl3emjef	155	46	Mitophagy	Mitophagy	NNP
cord-289034-yl3emjef	155	47	in	in	IN
cord-289034-yl3emjef	155	48	Cardiovascular	Cardiovascular	NNP
cord-289034-yl3emjef	155	49	Diseases	Diseases	NNPS
cord-289034-yl3emjef	155	50	Mechanisms	Mechanisms	NNPS
cord-289034-yl3emjef	155	51	,	,	,
cord-289034-yl3emjef	155	52	pathophysiological	pathophysiological	JJ
cord-289034-yl3emjef	155	53	roles	role	NNS
cord-289034-yl3emjef	155	54	,	,	,
cord-289034-yl3emjef	155	55	and	and	CC
cord-289034-yl3emjef	155	56	analysis	analysis	NN
cord-289034-yl3emjef	155	57	Mitochondrial	Mitochondrial	NNP
cord-289034-yl3emjef	155	58	Fission	Fission	NNP
cord-289034-yl3emjef	155	59	,	,	,
cord-289034-yl3emjef	155	60	Fusion	Fusion	NNP
cord-289034-yl3emjef	155	61	,	,	,
cord-289034-yl3emjef	155	62	and	and	CC
cord-289034-yl3emjef	155	63	Stress	Stress	NNP
cord-289034-yl3emjef	155	64	Mitophagy	Mitophagy	NNP
cord-289034-yl3emjef	155	65	and	and	CC
cord-289034-yl3emjef	155	66	cancer	cancer	NN
cord-289034-yl3emjef	155	67	Parkin	Parkin	NNP
cord-289034-yl3emjef	155	68	and	and	CC
cord-289034-yl3emjef	155	69	mitophagy	mitophagy	NN
cord-289034-yl3emjef	155	70	in	in	IN
cord-289034-yl3emjef	155	71	cancer	cancer	NN
cord-289034-yl3emjef	155	72	Mitophagy	Mitophagy	NNP
cord-289034-yl3emjef	155	73	in	in	IN
cord-289034-yl3emjef	155	74	neurodegeneration	neurodegeneration	NN
cord-289034-yl3emjef	155	75	and	and	CC
cord-289034-yl3emjef	155	76	aging	age	VBG
cord-289034-yl3emjef	155	77	A	a	DT
cord-289034-yl3emjef	155	78	Case	case	NN
cord-289034-yl3emjef	155	79	of	of	IN
cord-289034-yl3emjef	155	80	Severe	Severe	NNP
cord-289034-yl3emjef	155	81	Hypermetabolism	Hypermetabolism	NNP
cord-289034-yl3emjef	155	82	Of	of	IN
cord-289034-yl3emjef	155	83	Nonthyroid	Nonthyroid	NNP
cord-289034-yl3emjef	155	84	Origin	Origin	NNP
cord-289034-yl3emjef	155	85	With	with	IN
cord-289034-yl3emjef	155	86	A	a	DT
cord-289034-yl3emjef	155	87	Defect	defect	NN
cord-289034-yl3emjef	155	88	In	in	IN
cord-289034-yl3emjef	155	89	The	the	DT
cord-289034-yl3emjef	155	90	Maintenance	maintenance	NN
cord-289034-yl3emjef	155	91	of	of	IN
cord-289034-yl3emjef	155	92	Mitochondrial	Mitochondrial	NNP
cord-289034-yl3emjef	155	93	Respiratory	Respiratory	NNP
cord-289034-yl3emjef	155	94	Control	Control	NNP
cord-289034-yl3emjef	155	95	:	:	:
cord-289034-yl3emjef	156	1	A	a	DT
cord-289034-yl3emjef	156	2	Correlated	Correlated	NNP
cord-289034-yl3emjef	156	3	Clinical	Clinical	NNP
cord-289034-yl3emjef	156	4	,	,	,
cord-289034-yl3emjef	156	5	Biochemical	biochemical	JJ
cord-289034-yl3emjef	156	6	,	,	,
cord-289034-yl3emjef	156	7	and	and	CC
cord-289034-yl3emjef	156	8	Morphological	Morphological	NNP
cord-289034-yl3emjef	156	9	Study	Study	NNP
cord-289034-yl3emjef	156	10	Mitochondrial	Mitochondrial	NNP
cord-289034-yl3emjef	156	11	diseases	disease	NNS
cord-289034-yl3emjef	156	12	Contribution	Contribution	NNP
cord-289034-yl3emjef	156	13	of	of	IN
cord-289034-yl3emjef	156	14	glutathione	glutathione	NN
cord-289034-yl3emjef	156	15	status	status	NN
cord-289034-yl3emjef	156	16	to	to	IN
cord-289034-yl3emjef	156	17	oxidant	oxidant	JJ
cord-289034-yl3emjef	156	18	-	-	HYPH
cord-289034-yl3emjef	156	19	induced	induce	VBN
cord-289034-yl3emjef	156	20	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	156	21	DNA	dna	NN
cord-289034-yl3emjef	156	22	damage	damage	NN
cord-289034-yl3emjef	156	23	in	in	IN
cord-289034-yl3emjef	156	24	colonic	colonic	JJ
cord-289034-yl3emjef	156	25	epithelial	epithelial	JJ
cord-289034-yl3emjef	156	26	cells	cell	NNS
cord-289034-yl3emjef	156	27	.	.	.
cord-289034-yl3emjef	157	1	Free	free	JJ
cord-289034-yl3emjef	157	2	Radic	Radic	NNP
cord-289034-yl3emjef	157	3	Troglitazone	Troglitazone	NNP
cord-289034-yl3emjef	157	4	,	,	,
cord-289034-yl3emjef	157	5	but	but	CC
cord-289034-yl3emjef	157	6	not	not	RB
cord-289034-yl3emjef	157	7	rosiglitazone	rosiglitazone	NN
cord-289034-yl3emjef	157	8	,	,	,
cord-289034-yl3emjef	157	9	damages	damage	NNS
cord-289034-yl3emjef	157	10	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	157	11	DNA	dna	NN
cord-289034-yl3emjef	157	12	and	and	CC
cord-289034-yl3emjef	157	13	induces	induce	VBZ
cord-289034-yl3emjef	157	14	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	157	15	dysfunction	dysfunction	NN
cord-289034-yl3emjef	157	16	and	and	CC
cord-289034-yl3emjef	157	17	cell	cell	NN
cord-289034-yl3emjef	157	18	death	death	NN
cord-289034-yl3emjef	157	19	in	in	IN
cord-289034-yl3emjef	157	20	human	human	JJ
cord-289034-yl3emjef	157	21	hepatocytes	hepatocyte	NNS
cord-289034-yl3emjef	157	22	Mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	157	23	and	and	CC
cord-289034-yl3emjef	157	24	cell	cell	NN
cord-289034-yl3emjef	157	25	signalling	signal	VBG
cord-289034-yl3emjef	157	26	Mitochondrial	Mitochondrial	NNP
cord-289034-yl3emjef	157	27	Dysfunction	Dysfunction	NNP
cord-289034-yl3emjef	157	28	:	:	:
cord-289034-yl3emjef	157	29	A	a	DT
cord-289034-yl3emjef	157	30	Novel	Novel	NNP
cord-289034-yl3emjef	157	31	Potential	Potential	NNP
cord-289034-yl3emjef	157	32	Driver	driver	NN
cord-289034-yl3emjef	157	33	of	of	IN
cord-289034-yl3emjef	157	34	Epithelial	epithelial	NN
cord-289034-yl3emjef	157	35	-	-	HYPH
cord-289034-yl3emjef	157	36	to	to	IN
cord-289034-yl3emjef	157	37	-	-	HYPH
cord-289034-yl3emjef	157	38	Mesenchymal	Mesenchymal	NNP
cord-289034-yl3emjef	157	39	Transition	Transition	NNP
cord-289034-yl3emjef	157	40	in	in	IN
cord-289034-yl3emjef	157	41	Cancer	Cancer	NNP
cord-289034-yl3emjef	157	42	Mitochondrial	Mitochondrial	NNP
cord-289034-yl3emjef	157	43	dysfunction	dysfunction	NN
cord-289034-yl3emjef	157	44	and	and	CC
cord-289034-yl3emjef	157	45	mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	157	46	dynamics-	dynamics-	XX
cord-289034-yl3emjef	158	1	The	the	DT
cord-289034-yl3emjef	158	2	cancer	cancer	NN
cord-289034-yl3emjef	158	3	connection	connection	NN
cord-289034-yl3emjef	158	4	Evolution	evolution	NN
cord-289034-yl3emjef	158	5	of	of	IN
cord-289034-yl3emjef	158	6	Mitochondria	Mitochondria	NNP
cord-289034-yl3emjef	158	7	as	as	IN
cord-289034-yl3emjef	158	8	Signaling	Signaling	NNP
cord-289034-yl3emjef	158	9	Organelles	Organelles	NNP
cord-289034-yl3emjef	159	1	The	the	DT
cord-289034-yl3emjef	159	2	world	world	NN
cord-289034-yl3emjef	159	3	of	of	IN
cord-289034-yl3emjef	159	4	protein	protein	NN
cord-289034-yl3emjef	159	5	acetylation	acetylation	NN
cord-289034-yl3emjef	160	1	The	the	DT
cord-289034-yl3emjef	160	2	Interface	Interface	NNP
cord-289034-yl3emjef	160	3	Between	between	IN
cord-289034-yl3emjef	160	4	ER	ER	NNP
cord-289034-yl3emjef	160	5	and	and	CC
cord-289034-yl3emjef	160	6	Mitochondria	Mitochondria	NNP
cord-289034-yl3emjef	160	7	:	:	:
cord-289034-yl3emjef	160	8	Molecular	Molecular	NNP
cord-289034-yl3emjef	160	9	Compositions	Compositions	NNPS
cord-289034-yl3emjef	160	10	and	and	CC
cord-289034-yl3emjef	160	11	Functions	function	NNS
cord-289034-yl3emjef	161	1	The	the	DT
cord-289034-yl3emjef	161	2	Rise	rise	NN
cord-289034-yl3emjef	161	3	of	of	IN
cord-289034-yl3emjef	161	4	Mitochondria	Mitochondria	NNP
cord-289034-yl3emjef	161	5	in	in	IN
cord-289034-yl3emjef	161	6	Peripheral	Peripheral	NNP
cord-289034-yl3emjef	161	7	Arterial	Arterial	NNP
cord-289034-yl3emjef	161	8	Disease	Disease	NNP
cord-289034-yl3emjef	161	9	Physiopathology	Physiopathology	NNP
cord-289034-yl3emjef	161	10	:	:	:
cord-289034-yl3emjef	162	1	Experimental	experimental	JJ
cord-289034-yl3emjef	162	2	and	and	CC
cord-289034-yl3emjef	162	3	Clinical	Clinical	NNP
cord-289034-yl3emjef	162	4	Data	Data	NNP
cord-289034-yl3emjef	163	1	Targeting	target	VBG
cord-289034-yl3emjef	163	2	mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	163	3	for	for	IN
cord-289034-yl3emjef	163	4	cardiovascular	cardiovascular	JJ
cord-289034-yl3emjef	163	5	disorders	disorder	NNS
cord-289034-yl3emjef	163	6	:	:	:
cord-289034-yl3emjef	163	7	Therapeutic	therapeutic	JJ
cord-289034-yl3emjef	163	8	potential	potential	NN
cord-289034-yl3emjef	163	9	and	and	CC
cord-289034-yl3emjef	163	10	obstacles	obstacle	NNS
cord-289034-yl3emjef	164	1	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	164	2	reactive	reactive	JJ
cord-289034-yl3emjef	164	3	oxygen	oxygen	NN
cord-289034-yl3emjef	164	4	species	specie	NNS
cord-289034-yl3emjef	164	5	and	and	CC
cord-289034-yl3emjef	164	6	inflammation	inflammation	NN
cord-289034-yl3emjef	164	7	:	:	:
cord-289034-yl3emjef	164	8	Molecular	molecular	JJ
cord-289034-yl3emjef	164	9	mechanisms	mechanism	NNS
cord-289034-yl3emjef	164	10	,	,	,
cord-289034-yl3emjef	164	11	diseases	disease	NNS
cord-289034-yl3emjef	164	12	and	and	CC
cord-289034-yl3emjef	164	13	promising	promising	JJ
cord-289034-yl3emjef	164	14	therapies	therapy	NNS
cord-289034-yl3emjef	164	15	Inflammasomes	Inflammasomes	NNP
cord-289034-yl3emjef	164	16	in	in	IN
cord-289034-yl3emjef	164	17	carcinogenesis	carcinogenesis	NN
cord-289034-yl3emjef	164	18	and	and	CC
cord-289034-yl3emjef	164	19	anticancer	anticancer	JJ
cord-289034-yl3emjef	164	20	immune	immune	JJ
cord-289034-yl3emjef	164	21	responses	response	NNS
cord-289034-yl3emjef	165	1	The	the	DT
cord-289034-yl3emjef	165	2	Role	role	NN
cord-289034-yl3emjef	165	3	of	of	IN
cord-289034-yl3emjef	165	4	Mitochondria	Mitochondria	NNP
cord-289034-yl3emjef	165	5	in	in	IN
cord-289034-yl3emjef	165	6	Inflammation	inflammation	NN
cord-289034-yl3emjef	165	7	:	:	:
cord-289034-yl3emjef	166	1	From	from	IN
cord-289034-yl3emjef	166	2	Cancer	Cancer	NNP
cord-289034-yl3emjef	166	3	to	to	IN
cord-289034-yl3emjef	166	4	Neurodegenerative	Neurodegenerative	NNP
cord-289034-yl3emjef	166	5	Disorders	Disorders	NNPS
cord-289034-yl3emjef	166	6	Mitochondrial	Mitochondrial	NNP
cord-289034-yl3emjef	166	7	Dysfunction	Dysfunction	NNP
cord-289034-yl3emjef	166	8	in	in	IN
cord-289034-yl3emjef	166	9	Aging	age	VBG
cord-289034-yl3emjef	166	10	and	and	CC
cord-289034-yl3emjef	166	11	Cancer	Cancer	NNP
cord-289034-yl3emjef	166	12	Melatonin	Melatonin	NNP
cord-289034-yl3emjef	166	13	Inhibits	inhibit	VBZ
cord-289034-yl3emjef	166	14	COVID-19-induced	covid-19-induce	VBN
cord-289034-yl3emjef	166	15	Cytokine	cytokine	NN
cord-289034-yl3emjef	166	16	Storm	storm	NN
cord-289034-yl3emjef	166	17	by	by	IN
cord-289034-yl3emjef	166	18	Reversing	reverse	VBG
cord-289034-yl3emjef	166	19	Aerobic	Aerobic	NNP
cord-289034-yl3emjef	166	20	Glycolysis	Glycolysis	NNP
cord-289034-yl3emjef	166	21	in	in	IN
cord-289034-yl3emjef	166	22	Immune	Immune	NNP
cord-289034-yl3emjef	166	23	Cells	cell	NNS
cord-289034-yl3emjef	166	24	:	:	:
cord-289034-yl3emjef	167	1	A	a	DT
cord-289034-yl3emjef	167	2	Mechanistic	Mechanistic	NNP
cord-289034-yl3emjef	167	3	Analysis	Analysis	NNP
cord-289034-yl3emjef	167	4	Clinical	clinical	JJ
cord-289034-yl3emjef	167	5	features	feature	NNS
cord-289034-yl3emjef	167	6	of	of	IN
cord-289034-yl3emjef	167	7	patients	patient	NNS
cord-289034-yl3emjef	167	8	infected	infect	VBN
cord-289034-yl3emjef	167	9	with	with	IN
cord-289034-yl3emjef	167	10	2019	2019	CD
cord-289034-yl3emjef	167	11	novel	novel	JJ
cord-289034-yl3emjef	167	12	coronavirus	coronavirus	NN
cord-289034-yl3emjef	167	13	in	in	IN
cord-289034-yl3emjef	167	14	The	the	DT
cord-289034-yl3emjef	167	15	cytokine	cytokine	NN
cord-289034-yl3emjef	167	16	storm	storm	NN
cord-289034-yl3emjef	167	17	in	in	IN
cord-289034-yl3emjef	167	18	COVID-19	COVID-19	NNP
cord-289034-yl3emjef	167	19	:	:	:
cord-289034-yl3emjef	167	20	An	an	DT
cord-289034-yl3emjef	167	21	overview	overview	NN
cord-289034-yl3emjef	167	22	of	of	IN
cord-289034-yl3emjef	167	23	the	the	DT
cord-289034-yl3emjef	167	24	involvement	involvement	NN
cord-289034-yl3emjef	167	25	of	of	IN
cord-289034-yl3emjef	167	26	the	the	DT
cord-289034-yl3emjef	167	27	chemokine	chemokine	NN
cord-289034-yl3emjef	167	28	/	/	SYM
cord-289034-yl3emjef	167	29	chemokine	chemokine	NN
cord-289034-yl3emjef	167	30	-	-	HYPH
cord-289034-yl3emjef	167	31	receptor	receptor	NN
cord-289034-yl3emjef	167	32	system	system	NN
cord-289034-yl3emjef	167	33	Network	network	NN
cord-289034-yl3emjef	167	34	-	-	HYPH
cord-289034-yl3emjef	167	35	Based	Based	NNP
cord-289034-yl3emjef	167	36	Approaches	Approaches	NNPS
cord-289034-yl3emjef	167	37	for	for	IN
cord-289034-yl3emjef	167	38	Multi	multi	JJ
cord-289034-yl3emjef	167	39	-	-	HYPH
cord-289034-yl3emjef	167	40	omics	omics	JJ
cord-289034-yl3emjef	167	41	Integration	integration	NN
cord-289034-yl3emjef	168	1	Can	Can	MD
cord-289034-yl3emjef	168	2	melatonin	melatonin	NN
cord-289034-yl3emjef	168	3	reduce	reduce	VB
cord-289034-yl3emjef	168	4	the	the	DT
cord-289034-yl3emjef	168	5	severity	severity	NN
cord-289034-yl3emjef	168	6	of	of	IN
cord-289034-yl3emjef	168	7	COVID-19	covid-19	JJ
cord-289034-yl3emjef	168	8	pandemic	pandemic	NN
cord-289034-yl3emjef	168	9	?	?	.
cord-289034-yl3emjef	169	1	COVID-19	covid-19	LS
cord-289034-yl3emjef	169	2	:	:	:
cord-289034-yl3emjef	169	3	Melatonin	melatonin	NN
cord-289034-yl3emjef	169	4	as	as	IN
cord-289034-yl3emjef	169	5	a	a	DT
cord-289034-yl3emjef	169	6	potential	potential	JJ
cord-289034-yl3emjef	169	7	adjuvant	adjuvant	NN
cord-289034-yl3emjef	169	8	treatment	treatment	NN
cord-289034-yl3emjef	169	9	Correspondence	Correspondence	NNP
cord-289034-yl3emjef	169	10	COVID-19	COVID-19	NNP
cord-289034-yl3emjef	169	11	:	:	:
cord-289034-yl3emjef	169	12	Melatonin	melatonin	NN
cord-289034-yl3emjef	169	13	as	as	IN
cord-289034-yl3emjef	169	14	a	a	DT
cord-289034-yl3emjef	169	15	potential	potential	JJ
cord-289034-yl3emjef	169	16	adjuvant	adjuvant	NN
cord-289034-yl3emjef	169	17	treatment	treatment	NN
cord-289034-yl3emjef	169	18	Comment	comment	NN
cord-289034-yl3emjef	169	19	on	on	IN
cord-289034-yl3emjef	169	20	Melatonin	Melatonin	NNP
cord-289034-yl3emjef	169	21	as	as	IN
cord-289034-yl3emjef	169	22	a	a	DT
cord-289034-yl3emjef	169	23	potential	potential	JJ
cord-289034-yl3emjef	169	24	adjuvant	adjuvant	NN
cord-289034-yl3emjef	169	25	treatment	treatment	NN
cord-289034-yl3emjef	169	26	for	for	IN
cord-289034-yl3emjef	169	27	COVID-19	COVID-19	NNP
cord-289034-yl3emjef	169	28	The	the	DT
cord-289034-yl3emjef	169	29	Mitochondrial	Mitochondrial	NNP
cord-289034-yl3emjef	169	30	Basis	Basis	NNP
cord-289034-yl3emjef	169	31	of	of	IN
cord-289034-yl3emjef	169	32	Aging	age	VBG
cord-289034-yl3emjef	169	33	Quantitative	quantitative	JJ
cord-289034-yl3emjef	169	34	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	169	35	DNA	dna	NN
cord-289034-yl3emjef	169	36	copy	copy	NN
cord-289034-yl3emjef	169	37	number	number	NN
cord-289034-yl3emjef	169	38	determination	determination	NN
cord-289034-yl3emjef	169	39	using	use	VBG
cord-289034-yl3emjef	169	40	droplet	droplet	NN
cord-289034-yl3emjef	169	41	digital	digital	JJ
cord-289034-yl3emjef	169	42	PCR	PCR	NNP
cord-289034-yl3emjef	169	43	with	with	IN
cord-289034-yl3emjef	169	44	single	single	JJ
cord-289034-yl3emjef	169	45	-	-	HYPH
cord-289034-yl3emjef	169	46	cell	cell	NN
cord-289034-yl3emjef	169	47	resolution	resolution	NN
cord-289034-yl3emjef	169	48	A	a	DT
cord-289034-yl3emjef	169	49	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	169	50	specific	specific	JJ
cord-289034-yl3emjef	169	51	stress	stress	NN
cord-289034-yl3emjef	169	52	response	response	NN
cord-289034-yl3emjef	169	53	in	in	IN
cord-289034-yl3emjef	169	54	mammalian	mammalian	JJ
cord-289034-yl3emjef	169	55	cells	cell	NNS
cord-289034-yl3emjef	170	1	UPRmt	uprmt	LS
cord-289034-yl3emjef	170	2	regulation	regulation	NN
cord-289034-yl3emjef	170	3	and	and	CC
cord-289034-yl3emjef	170	4	output	output	NN
cord-289034-yl3emjef	170	5	:	:	:
cord-289034-yl3emjef	171	1	A	a	DT
cord-289034-yl3emjef	171	2	stress	stress	NN
cord-289034-yl3emjef	171	3	response	response	NN
cord-289034-yl3emjef	171	4	mediated	mediate	VBN
cord-289034-yl3emjef	171	5	by	by	IN
cord-289034-yl3emjef	171	6	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	171	7	-	-	HYPH
cord-289034-yl3emjef	171	8	nuclear	nuclear	JJ
cord-289034-yl3emjef	171	9	communication	communication	NN
cord-289034-yl3emjef	172	1	Autophagy	Autophagy	NNP
cord-289034-yl3emjef	172	2	maintains	maintain	VBZ
cord-289034-yl3emjef	172	3	stemness	stemness	JJ
cord-289034-yl3emjef	172	4	by	by	IN
cord-289034-yl3emjef	172	5	preventing	prevent	VBG
cord-289034-yl3emjef	172	6	senescence	senescence	NN
cord-289034-yl3emjef	172	7	Coordination	Coordination	NNP
cord-289034-yl3emjef	172	8	of	of	IN
cord-289034-yl3emjef	172	9	mitophagy	mitophagy	NNS
cord-289034-yl3emjef	172	10	and	and	CC
cord-289034-yl3emjef	172	11	mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	172	12	biogenesis	biogenesis	NN
cord-289034-yl3emjef	172	13	during	during	IN
cord-289034-yl3emjef	172	14	ageing	age	VBG
cord-289034-yl3emjef	172	15	in	in	IN
cord-289034-yl3emjef	172	16	C.	C.	NNP
cord-289034-yl3emjef	172	17	elegans	elegan	NNS
cord-289034-yl3emjef	172	18	Mitochondria	mitochondrion	NNS
cord-289034-yl3emjef	172	19	in	in	IN
cord-289034-yl3emjef	172	20	the	the	DT
cord-289034-yl3emjef	172	21	pathophysiology	pathophysiology	NN
cord-289034-yl3emjef	172	22	of	of	IN
cord-289034-yl3emjef	172	23	Alzheimer	Alzheimer	NNP
cord-289034-yl3emjef	172	24	s	s	POS
cord-289034-yl3emjef	172	25	and	and	CC
cord-289034-yl3emjef	172	26	Parkinson	Parkinson	NNP
cord-289034-yl3emjef	172	27	s	s	POS
cord-289034-yl3emjef	172	28	diseases	disease	NNS
cord-289034-yl3emjef	173	1	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	173	2	Abnormalities	abnormality	NNS
cord-289034-yl3emjef	173	3	in	in	IN
cord-289034-yl3emjef	173	4	Alzheimer	Alzheimer	NNP
cord-289034-yl3emjef	173	5	's	's	POS
cord-289034-yl3emjef	173	6	Disease	Disease	NNP
cord-289034-yl3emjef	173	7	Decoding	Decoding	NNP
cord-289034-yl3emjef	173	8	Alzheimer	Alzheimer	NNP
cord-289034-yl3emjef	173	9	's	's	POS
cord-289034-yl3emjef	173	10	disease	disease	NN
cord-289034-yl3emjef	173	11	from	from	IN
cord-289034-yl3emjef	173	12	perturbed	perturbed	JJ
cord-289034-yl3emjef	173	13	cerebral	cerebral	JJ
cord-289034-yl3emjef	173	14	glucose	glucose	NN
cord-289034-yl3emjef	173	15	metabolism	metabolism	NN
cord-289034-yl3emjef	173	16	:	:	:
cord-289034-yl3emjef	174	1	Implications	implication	NNS
cord-289034-yl3emjef	174	2	for	for	IN
cord-289034-yl3emjef	174	3	diagnostic	diagnostic	JJ
cord-289034-yl3emjef	174	4	and	and	CC
cord-289034-yl3emjef	174	5	therapeutic	therapeutic	JJ
cord-289034-yl3emjef	174	6	strategies	strategy	NNS
cord-289034-yl3emjef	175	1	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	175	2	biology	biology	NN
cord-289034-yl3emjef	175	3	and	and	CC
cord-289034-yl3emjef	175	4	oxidative	oxidative	JJ
cord-289034-yl3emjef	175	5	stress	stress	NN
cord-289034-yl3emjef	175	6	in	in	IN
cord-289034-yl3emjef	175	7	Parkinson	Parkinson	NNP
cord-289034-yl3emjef	175	8	disease	disease	NN
cord-289034-yl3emjef	175	9	pathogenesis	pathogenesis	NN
cord-289034-yl3emjef	175	10	High	high	JJ
cord-289034-yl3emjef	175	11	aggregate	aggregate	JJ
cord-289034-yl3emjef	175	12	burden	burden	NN
cord-289034-yl3emjef	175	13	of	of	IN
cord-289034-yl3emjef	175	14	somatic	somatic	JJ
cord-289034-yl3emjef	175	15	mtDNA	mtdna	NN
cord-289034-yl3emjef	175	16	point	point	NN
cord-289034-yl3emjef	175	17	mutations	mutation	NNS
cord-289034-yl3emjef	175	18	in	in	IN
cord-289034-yl3emjef	175	19	aging	age	VBG
cord-289034-yl3emjef	175	20	and	and	CC
cord-289034-yl3emjef	175	21	Alzheimer	Alzheimer	NNP
cord-289034-yl3emjef	175	22	's	's	POS
cord-289034-yl3emjef	175	23	disease	disease	NN
cord-289034-yl3emjef	175	24	brain	brain	NN
cord-289034-yl3emjef	175	25	Mitophagy	Mitophagy	NNP
cord-289034-yl3emjef	175	26	and	and	CC
cord-289034-yl3emjef	175	27	NAD+	NAD+	NNP
cord-289034-yl3emjef	175	28	inhibit	inhibit	VBP
cord-289034-yl3emjef	175	29	Alzheimer	Alzheimer	NNP
cord-289034-yl3emjef	175	30	disease	disease	NN
cord-289034-yl3emjef	176	1	What	what	WP
cord-289034-yl3emjef	176	2	can	can	MD
cord-289034-yl3emjef	176	3	we	-PRON-	PRP
cord-289034-yl3emjef	176	4	Learn	learn	VB
cord-289034-yl3emjef	176	5	about	about	IN
cord-289034-yl3emjef	176	6	Parkinson	Parkinson	NNP
cord-289034-yl3emjef	176	7	's	's	POS
cord-289034-yl3emjef	176	8	Disease	Disease	NNP
cord-289034-yl3emjef	176	9	Pathobiology	Pathobiology	NNP
cord-289034-yl3emjef	176	10	?	?	.
cord-289034-yl3emjef	177	1	Variants	variant	NNS
cord-289034-yl3emjef	177	2	in	in	IN
cord-289034-yl3emjef	178	1	Miro1	miro1	JJ
cord-289034-yl3emjef	178	2	Cause	Cause	NNP
cord-289034-yl3emjef	178	3	Alterations	Alterations	NNPS
cord-289034-yl3emjef	178	4	of	of	IN
cord-289034-yl3emjef	178	5	ER	ER	NNP
cord-289034-yl3emjef	178	6	-	-	HYPH
cord-289034-yl3emjef	178	7	Mitochondria	Mitochondria	NNP
cord-289034-yl3emjef	178	8	Contact	Contact	NNP
cord-289034-yl3emjef	178	9	Sites	Sites	NNPS
cord-289034-yl3emjef	178	10	in	in	IN
cord-289034-yl3emjef	178	11	Fibroblasts	Fibroblasts	NNPS
cord-289034-yl3emjef	178	12	from	from	IN
cord-289034-yl3emjef	178	13	Parkinson	Parkinson	NNP
cord-289034-yl3emjef	178	14	's	's	POS
cord-289034-yl3emjef	178	15	Disease	Disease	NNP
cord-289034-yl3emjef	178	16	Patients	Patients	NNP
cord-289034-yl3emjef	178	17	Cycle	Cycle	NNP
cord-289034-yl3emjef	178	18	Defects	Defects	NNPS
cord-289034-yl3emjef	178	19	and	and	CC
cord-289034-yl3emjef	178	20	Cancer	cancer	NN
cord-289034-yl3emjef	178	21	:	:	:
cord-289034-yl3emjef	178	22	When	when	WRB
cord-289034-yl3emjef	178	23	Metabolism	Metabolism	NNP
cord-289034-yl3emjef	178	24	Tunes	Tunes	NNP
cord-289034-yl3emjef	178	25	Redox	Redox	NNP
cord-289034-yl3emjef	178	26	State	State	NNP
cord-289034-yl3emjef	178	27	Fumarate	Fumarate	NNP
cord-289034-yl3emjef	178	28	hydratase	hydratase	NN
cord-289034-yl3emjef	178	29	in	in	IN
cord-289034-yl3emjef	178	30	cancer	cancer	NN
cord-289034-yl3emjef	178	31	:	:	:
cord-289034-yl3emjef	178	32	A	a	DT
cord-289034-yl3emjef	178	33	multifaceted	multifaceted	JJ
cord-289034-yl3emjef	178	34	tumour	tumour	NN
cord-289034-yl3emjef	178	35	suppressor	suppressor	NN
cord-289034-yl3emjef	178	36	Rescue	Rescue	NNP
cord-289034-yl3emjef	178	37	of	of	IN
cord-289034-yl3emjef	178	38	TCA	TCA	NNP
cord-289034-yl3emjef	178	39	Cycle	Cycle	NNP
cord-289034-yl3emjef	178	40	Dysfunction	Dysfunction	NNP
cord-289034-yl3emjef	178	41	for	for	IN
cord-289034-yl3emjef	178	42	Cancer	Cancer	NNP
cord-289034-yl3emjef	178	43	Therapy	Therapy	NNP
cord-289034-yl3emjef	178	44	Mitochondrial	Mitochondrial	NNP
cord-289034-yl3emjef	178	45	genome	genome	NN
cord-289034-yl3emjef	178	46	variation	variation	NN
cord-289034-yl3emjef	178	47	and	and	CC
cord-289034-yl3emjef	178	48	prostate	prostate	NN
cord-289034-yl3emjef	178	49	cancer	cancer	NN
cord-289034-yl3emjef	178	50	:	:	:
cord-289034-yl3emjef	179	1	A	a	DT
cord-289034-yl3emjef	179	2	review	review	NN
cord-289034-yl3emjef	179	3	of	of	IN
cord-289034-yl3emjef	179	4	the	the	DT
cord-289034-yl3emjef	179	5	mutational	mutational	JJ
cord-289034-yl3emjef	179	6	landscape	landscape	NN
cord-289034-yl3emjef	179	7	and	and	CC
cord-289034-yl3emjef	179	8	application	application	NN
cord-289034-yl3emjef	179	9	to	to	IN
cord-289034-yl3emjef	179	10	clinical	clinical	JJ
cord-289034-yl3emjef	179	11	management	management	NN
cord-289034-yl3emjef	180	1	ROS	ROS	NNP
cord-289034-yl3emjef	180	2	-	-	HYPH
cord-289034-yl3emjef	180	3	Generating	generating	NN
cord-289034-yl3emjef	180	4	Mitochondrial	mitochondrial	NN
cord-289034-yl3emjef	181	1	DNA	DNA	NNP
cord-289034-yl3emjef	181	2	Mutations	mutation	NNS
cord-289034-yl3emjef	181	3	Can	Can	MD
cord-289034-yl3emjef	181	4	Regulate	regulate	VB
cord-289034-yl3emjef	181	5	Tumor	tumor	NN
cord-289034-yl3emjef	181	6	Cell	cell	NN
cord-289034-yl3emjef	181	7	Metastasis	metastasis	NN
cord-289034-yl3emjef	181	8	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	181	9	DNA	dna	NN
cord-289034-yl3emjef	181	10	depletion	depletion	NN
cord-289034-yl3emjef	181	11	in	in	IN
cord-289034-yl3emjef	181	12	prostate	prostate	NN
cord-289034-yl3emjef	181	13	epithelial	epithelial	JJ
cord-289034-yl3emjef	181	14	cells	cell	NNS
cord-289034-yl3emjef	181	15	promotes	promote	VBZ
cord-289034-yl3emjef	181	16	anoikis	anoikis	NN
cord-289034-yl3emjef	181	17	resistance	resistance	NN
cord-289034-yl3emjef	181	18	and	and	CC
cord-289034-yl3emjef	181	19	invasion	invasion	NN
cord-289034-yl3emjef	181	20	through	through	IN
cord-289034-yl3emjef	181	21	activation	activation	NN
cord-289034-yl3emjef	181	22	of	of	IN
cord-289034-yl3emjef	181	23	PI3K/	PI3K/	NNP
cord-289034-yl3emjef	182	1	Akt2	Akt2	NNP
cord-289034-yl3emjef	182	2	Mitochondrial	mitochondrial	JJ
cord-289034-yl3emjef	182	3	DNA	dna	NN
cord-289034-yl3emjef	182	4	depletion	depletion	NN
cord-289034-yl3emjef	183	1	sensitizes	sensitize	VBZ
cord-289034-yl3emjef	183	2	cancer	cancer	NN
cord-289034-yl3emjef	183	3	cells	cell	NNS
cord-289034-yl3emjef	183	4	to	to	IN
cord-289034-yl3emjef	183	5	PARP	PARP	NNP
cord-289034-yl3emjef	183	6	inhibitors	inhibitor	NNS
cord-289034-yl3emjef	183	7	by	by	IN
cord-289034-yl3emjef	183	8	translational	translational	JJ
cord-289034-yl3emjef	183	9	and	and	CC
cord-289034-yl3emjef	183	10	post	post	JJ
cord-289034-yl3emjef	183	11	-	-	JJ
cord-289034-yl3emjef	183	12	translational	translational	JJ
cord-289034-yl3emjef	183	13	repression	repression	NN
cord-289034-yl3emjef	183	14	of	of	IN
cord-289034-yl3emjef	183	15	BRCA2	BRCA2	NNP
cord-289034-yl3emjef	183	16	Miro1	Miro1	NNP
cord-289034-yl3emjef	183	17	Marks	Marks	NNP
cord-289034-yl3emjef	183	18	Parkinson	Parkinson	NNP
cord-289034-yl3emjef	183	19	's	's	POS
cord-289034-yl3emjef	183	20	Disease	Disease	NNP
cord-289034-yl3emjef	183	21	Subset	Subset	NNP
cord-289034-yl3emjef	183	22	and	and	CC
cord-289034-yl3emjef	183	23	Miro1	miro1	JJ
cord-289034-yl3emjef	183	24	Reducer	reducer	NN
cord-289034-yl3emjef	183	25	Rescues	rescue	VBZ
cord-289034-yl3emjef	183	26	Neuron	Neuron	NNP
cord-289034-yl3emjef	183	27	Loss	Loss	NNP
cord-289034-yl3emjef	183	28	in	in	IN
cord-289034-yl3emjef	183	29	Parkinson	Parkinson	NNP
cord-289034-yl3emjef	183	30	's	's	POS
cord-289034-yl3emjef	183	31	Models	model	NNS
cord-289034-yl3emjef	184	1	This	this	DT
cord-289034-yl3emjef	184	2	article	article	NN
cord-289034-yl3emjef	184	3	is	be	VBZ
cord-289034-yl3emjef	184	4	an	an	DT
cord-289034-yl3emjef	184	5	open	open	JJ
cord-289034-yl3emjef	184	6	access	access	NN
cord-289034-yl3emjef	184	7	article	article	NN
cord-289034-yl3emjef	184	8	distributed	distribute	VBN
cord-289034-yl3emjef	184	9	under	under	IN
cord-289034-yl3emjef	184	10	the	the	DT
cord-289034-yl3emjef	184	11	terms	term	NNS
cord-289034-yl3emjef	184	12	and	and	CC
cord-289034-yl3emjef	184	13	conditions	condition	NNS
cord-289034-yl3emjef	184	14	of	of	IN
cord-289034-yl3emjef	184	15	the	the	DT
cord-289034-yl3emjef	184	16	Creative	Creative	NNP
cord-289034-yl3emjef	184	17	Commons	Commons	NNP
cord-289034-yl3emjef	184	18	Attribution	Attribution	NNP
cord-289034-yl3emjef	184	19	(	(	-LRB-
cord-289034-yl3emjef	184	20	CC	CC	NNP
cord-289034-yl3emjef	184	21	BY	by	IN
cord-289034-yl3emjef	184	22	)	)	-RRB-
cord-289034-yl3emjef	184	23	license	license	NN