id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336810-77wq9laa	Klocperk, Adam	Complex Immunometabolic Profiling Reveals the Activation of Cellular Immunity and Biliary Lesions in Patients with Severe COVID-19	2020-09-17		.txt	text/plain	4679	207	43	Therefore, we observed a gradual increase of CRP, procalcitonin, ferritin, and serum IL-6 corresponding to the severity of the disease; however, these markers displayed a relative failure to upregulate in patients with a fatal course, who instead displayed high sIL2R and D-dimers ( Figure 1C ). Most markers of inflammation, the immune response, and liver damage presented in patients with a fatal course of COVID-19 so far seem mostly on par with those seen in patients with a moderate form of the disease, suggesting a weaker response to the infection compared to severely ill patients, which resulted in the patients' deaths. In contrast, patients with fatal COVID-19 ( Figure 5B ) displayed a negative correlation between leukocytes and lymphocytes, and their inflammatory markers increased with markers of organ failure (liver enzymes, amylase, GGT, urea, and creatinine) and cytotoxic cellular immunity (activated CD38+ HLA-DR+ CD8 T cells) instead.	./cache/cord-336810-77wq9laa.txt	./txt/cord-336810-77wq9laa.txt