id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-320882-cr0ccsnp	Li Volti, Giovanni	Smoking and SARS-CoV-2 Disease (COVID-19): Dangerous Liaisons or Confusing Relationships?	2020-05-02		.txt	text/plain	1235	69	47	Keywords: COVID-19; SARS-Cov-2; smoking; angiotensin-converting enzyme-2 We read with great interest the article by Brake SJ and colleagues [1] investigating the relationship between smoking and angiotensin-converting enzyme-2 (ACE-2) and the potential implication for COVID-19. The authors present findings linking ACE-2 expression to smoking in a variety of experimental models together with observations of their own; immunohistochemistry data showing an increased expression of ACE-2 in a series of biopsies from a group of current smokers with chronic obstructive pulmonary disease when compared to a control group. The authors then venture into reporting existing Chinese case reports to support their hypothesis that smoking could increase the risk of COVID-19 via upregulation of ACE-2 expression, a known cellular entry gateway for SARS-CoV-2 [2] . Smoking upregulates angiotensin-converting enzyme-2 receptor: A potential adhesion site for novel coronavirus SARS-CoV-2 (Covid-19) Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: Molecular mechanisms and potential therapeutic target	./cache/cord-320882-cr0ccsnp.txt	./txt/cord-320882-cr0ccsnp.txt