id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289832-092dtzrd	Villard, Orianne	The Plasmatic Aldosterone and C-Reactive Protein Levels, and the Severity of Covid-19: The Dyhor-19 Study	2020-07-21		.txt	text/plain	3943	207	42	The new coronavirus SARS-CoV-2, responsible for the Covid-19 pandemic, uses the angiotensin converting enzyme type 2 (ACE2), a physiological inhibitor of the renin angiotensin aldosterone system (RAAS), as a cellular receptor to infect cells. In univariate analyses, aldosterone and C-reactive protein (CRP) levels at inclusion were significantly higher in patients with severe clinical course as compared to those with mild or moderate course (p < 0.01 and p = 0.03, respectively). Moreover, aldosterone levels were also gradually and significantly increased when we compared clinical status of patients in the three following categories: mild (OS ≤ 3), moderate (OS = 4) and severe (OS ≥ 5) on Day 2 and at OS max (analysis of variance, p = 0.001 and p = 0.006, respectively) ( Figure 2B) . In the present study, higher plasmatic aldosterone and CRP levels at inclusion are associated with severe clinical course of Covid-19 in hospitalized patients, and both parameters appear to be correlated.	./cache/cord-289832-092dtzrd.txt	./txt/cord-289832-092dtzrd.txt