id sid tid token lemma pos cord-309914-1lpl26eo 1 1 key key JJ cord-309914-1lpl26eo 1 2 : : : cord-309914-1lpl26eo 1 3 cord-309914 cord-309914 NNP cord-309914-1lpl26eo 1 4 - - HYPH cord-309914-1lpl26eo 1 5 1lpl26eo 1lpl26eo CD cord-309914-1lpl26eo 1 6 authors author NNS cord-309914-1lpl26eo 1 7 : : : cord-309914-1lpl26eo 1 8 Peterson Peterson NNP cord-309914-1lpl26eo 1 9 , , , cord-309914-1lpl26eo 1 10 Danielle Danielle NNP cord-309914-1lpl26eo 1 11 ; ; : cord-309914-1lpl26eo 1 12 Damsky Damsky NNP cord-309914-1lpl26eo 1 13 , , , cord-309914-1lpl26eo 1 14 William William NNP cord-309914-1lpl26eo 1 15 ; ; : cord-309914-1lpl26eo 1 16 King King NNP cord-309914-1lpl26eo 1 17 , , , cord-309914-1lpl26eo 1 18 Brett Brett NNP cord-309914-1lpl26eo 1 19 title title NN cord-309914-1lpl26eo 1 20 : : : cord-309914-1lpl26eo 1 21 The the DT cord-309914-1lpl26eo 1 22 use use NN cord-309914-1lpl26eo 1 23 of of IN cord-309914-1lpl26eo 1 24 Janus Janus NNP cord-309914-1lpl26eo 1 25 kinase kinase NN cord-309914-1lpl26eo 1 26 inhibitors inhibitor NNS cord-309914-1lpl26eo 1 27 in in IN cord-309914-1lpl26eo 1 28 the the DT cord-309914-1lpl26eo 1 29 time time NN cord-309914-1lpl26eo 1 30 of of IN cord-309914-1lpl26eo 1 31 SARS SARS NNP cord-309914-1lpl26eo 1 32 - - HYPH cord-309914-1lpl26eo 1 33 CoV-2 CoV-2 NNP cord-309914-1lpl26eo 1 34 date date NN cord-309914-1lpl26eo 1 35 : : : cord-309914-1lpl26eo 1 36 2020 2020 CD cord-309914-1lpl26eo 1 37 - - HYPH cord-309914-1lpl26eo 1 38 04 04 CD cord-309914-1lpl26eo 1 39 - - HYPH cord-309914-1lpl26eo 1 40 09 09 CD cord-309914-1lpl26eo 1 41 journal journal NN cord-309914-1lpl26eo 1 42 : : : cord-309914-1lpl26eo 2 1 J J NNP cord-309914-1lpl26eo 2 2 Am be VBP cord-309914-1lpl26eo 3 1 Acad Acad NNP cord-309914-1lpl26eo 3 2 Dermatol Dermatol NNP cord-309914-1lpl26eo 4 1 DOI DOI NNP cord-309914-1lpl26eo 4 2 : : : cord-309914-1lpl26eo 5 1 10.1016 10.1016 CD cord-309914-1lpl26eo 5 2 / / SYM cord-309914-1lpl26eo 5 3 j.jaad.2020.03.099 j.jaad.2020.03.099 CD cord-309914-1lpl26eo 5 4 sha sha NN cord-309914-1lpl26eo 5 5 : : : cord-309914-1lpl26eo 5 6 ad5dd2193095b5ede55e2968d10c5c2541a5ccf7 ad5dd2193095b5ede55e2968d10c5c2541a5ccf7 NNP cord-309914-1lpl26eo 5 7 doc_id doc_id NNPS cord-309914-1lpl26eo 5 8 : : : cord-309914-1lpl26eo 5 9 309914 309914 CD cord-309914-1lpl26eo 5 10 cord_uid cord_uid FW cord-309914-1lpl26eo 5 11 : : : cord-309914-1lpl26eo 6 1 1lpl26eo 1lpl26eo CD cord-309914-1lpl26eo 6 2 nan nan NNP cord-309914-1lpl26eo 7 1 During during IN cord-309914-1lpl26eo 7 2 the the DT cord-309914-1lpl26eo 7 3 time time NN cord-309914-1lpl26eo 7 4 of of IN cord-309914-1lpl26eo 7 5 the the DT cord-309914-1lpl26eo 7 6 SARS SARS NNP cord-309914-1lpl26eo 7 7 - - HYPH cord-309914-1lpl26eo 7 8 CoV-2 CoV-2 NNP cord-309914-1lpl26eo 7 9 pandemic pandemic NN cord-309914-1lpl26eo 7 10 , , , cord-309914-1lpl26eo 7 11 questions question NNS cord-309914-1lpl26eo 7 12 arise arise VBP cord-309914-1lpl26eo 7 13 regarding regard VBG cord-309914-1lpl26eo 7 14 patients patient NNS cord-309914-1lpl26eo 7 15 being be VBG cord-309914-1lpl26eo 7 16 treated treat VBN cord-309914-1lpl26eo 7 17 with with IN cord-309914-1lpl26eo 7 18 37 37 CD cord-309914-1lpl26eo 7 19 immunomodulatory immunomodulatory JJ cord-309914-1lpl26eo 7 20 therapies therapy NNS cord-309914-1lpl26eo 7 21 . . . cord-309914-1lpl26eo 8 1 In in IN cord-309914-1lpl26eo 8 2 particular particular JJ cord-309914-1lpl26eo 8 3 , , , cord-309914-1lpl26eo 8 4 is be VBZ cord-309914-1lpl26eo 8 5 there there EX cord-309914-1lpl26eo 8 6 an an DT cord-309914-1lpl26eo 8 7 increased increase VBN cord-309914-1lpl26eo 8 8 risk risk NN cord-309914-1lpl26eo 8 9 of of IN cord-309914-1lpl26eo 8 10 acquiring acquire VBG cord-309914-1lpl26eo 8 11 the the DT cord-309914-1lpl26eo 8 12 infection infection NN cord-309914-1lpl26eo 8 13 or or CC cord-309914-1lpl26eo 8 14 38 38 CD cord-309914-1lpl26eo 8 15 experiencing experience VBG cord-309914-1lpl26eo 8 16 a a DT cord-309914-1lpl26eo 8 17 worse bad JJR cord-309914-1lpl26eo 8 18 outcome outcome NN cord-309914-1lpl26eo 8 19 from from IN cord-309914-1lpl26eo 8 20 SARS SARS NNP cord-309914-1lpl26eo 8 21 - - HYPH cord-309914-1lpl26eo 8 22 CoV-2 CoV-2 NNP cord-309914-1lpl26eo 8 23 ? ? . cord-309914-1lpl26eo 9 1 While while IN cord-309914-1lpl26eo 9 2 this this DT cord-309914-1lpl26eo 9 3 exact exact JJ cord-309914-1lpl26eo 9 4 question question NN cord-309914-1lpl26eo 9 5 is be VBZ cord-309914-1lpl26eo 9 6 presently presently RB cord-309914-1lpl26eo 9 7 unanswerable unanswerable JJ cord-309914-1lpl26eo 9 8 , , , cord-309914-1lpl26eo 9 9 39 39 CD cord-309914-1lpl26eo 9 10 we -PRON- PRP cord-309914-1lpl26eo 9 11 can can MD cord-309914-1lpl26eo 9 12 look look VB cord-309914-1lpl26eo 9 13 at at IN cord-309914-1lpl26eo 9 14 safety safety NN cord-309914-1lpl26eo 9 15 data datum NNS cord-309914-1lpl26eo 9 16 from from IN cord-309914-1lpl26eo 9 17 clinical clinical JJ cord-309914-1lpl26eo 9 18 trials trial NNS cord-309914-1lpl26eo 9 19 to to TO cord-309914-1lpl26eo 9 20 try try VB cord-309914-1lpl26eo 9 21 to to TO cord-309914-1lpl26eo 9 22 understand understand VB cord-309914-1lpl26eo 9 23 patient patient JJ cord-309914-1lpl26eo 9 24 susceptibility susceptibility NN cord-309914-1lpl26eo 9 25 to to IN cord-309914-1lpl26eo 9 26 different different JJ cord-309914-1lpl26eo 9 27 40 40 CD cord-309914-1lpl26eo 9 28 infections infection NNS cord-309914-1lpl26eo 9 29 . . . cord-309914-1lpl26eo 10 1 While while IN cord-309914-1lpl26eo 10 2 others other NNS cord-309914-1lpl26eo 10 3 have have VBP cord-309914-1lpl26eo 10 4 addressed address VBN cord-309914-1lpl26eo 10 5 this this DT cord-309914-1lpl26eo 10 6 in in IN cord-309914-1lpl26eo 10 7 the the DT cord-309914-1lpl26eo 10 8 context context NN cord-309914-1lpl26eo 10 9 of of IN cord-309914-1lpl26eo 10 10 biologic biologic JJ cord-309914-1lpl26eo 10 11 1 1 CD cord-309914-1lpl26eo 10 12 or or CC cord-309914-1lpl26eo 10 13 classical classical JJ cord-309914-1lpl26eo 10 14 small small JJ cord-309914-1lpl26eo 10 15 molecule molecule NN cord-309914-1lpl26eo 10 16 41 41 CD cord-309914-1lpl26eo 10 17 therapy therapy NN cord-309914-1lpl26eo 10 18 2 2 CD cord-309914-1lpl26eo 10 19 , , , cord-309914-1lpl26eo 10 20 the the DT cord-309914-1lpl26eo 10 21 risk risk NN cord-309914-1lpl26eo 10 22 of of IN cord-309914-1lpl26eo 10 23 Janus Janus NNP cord-309914-1lpl26eo 10 24 kinase kinase NN cord-309914-1lpl26eo 10 25 inhibitor inhibitor NN cord-309914-1lpl26eo 10 26 ( ( -LRB- cord-309914-1lpl26eo 10 27 JAKi JAKi NNS cord-309914-1lpl26eo 10 28 ) ) -RRB- cord-309914-1lpl26eo 10 29 treatment treatment NN cord-309914-1lpl26eo 10 30 has have VBZ cord-309914-1lpl26eo 10 31 not not RB cord-309914-1lpl26eo 10 32 been be VBN cord-309914-1lpl26eo 10 33 addressed address VBN cord-309914-1lpl26eo 10 34 . . . cord-309914-1lpl26eo 11 1 In in IN cord-309914-1lpl26eo 11 2 light light NN cord-309914-1lpl26eo 11 3 of of IN cord-309914-1lpl26eo 11 4 the the DT cord-309914-1lpl26eo 11 5 42 42 CD cord-309914-1lpl26eo 11 6 growing grow VBG cord-309914-1lpl26eo 11 7 off off IN cord-309914-1lpl26eo 11 8 - - HYPH cord-309914-1lpl26eo 11 9 label label NN cord-309914-1lpl26eo 11 10 use use NN cord-309914-1lpl26eo 11 11 of of IN cord-309914-1lpl26eo 11 12 JAKi JAKi NNS cord-309914-1lpl26eo 11 13 in in IN cord-309914-1lpl26eo 11 14 dermatology dermatology NN cord-309914-1lpl26eo 11 15 in in IN cord-309914-1lpl26eo 11 16 addition addition NN cord-309914-1lpl26eo 11 17 to to IN cord-309914-1lpl26eo 11 18 pharmaceutical pharmaceutical NN cord-309914-1lpl26eo 11 19 industry industry NN cord-309914-1lpl26eo 11 20 sponsored sponsor VBD cord-309914-1lpl26eo 11 21 clinical clinical JJ cord-309914-1lpl26eo 11 22 43 43 CD cord-309914-1lpl26eo 11 23 trials trial NNS cord-309914-1lpl26eo 11 24 of of IN cord-309914-1lpl26eo 11 25 JAKi JAKi NNS cord-309914-1lpl26eo 11 26 for for IN cord-309914-1lpl26eo 11 27 alopecia alopecia NNP cord-309914-1lpl26eo 11 28 areata areata NNP cord-309914-1lpl26eo 11 29 , , , cord-309914-1lpl26eo 11 30 atopic atopic JJ cord-309914-1lpl26eo 11 31 dermatitis dermatitis NN cord-309914-1lpl26eo 11 32 , , , cord-309914-1lpl26eo 11 33 vitiligo vitiligo NN cord-309914-1lpl26eo 11 34 , , , cord-309914-1lpl26eo 11 35 etc etc FW cord-309914-1lpl26eo 11 36 , , , cord-309914-1lpl26eo 11 37 dermatologists dermatologist NNS cord-309914-1lpl26eo 11 38 need need VBP cord-309914-1lpl26eo 11 39 data datum NNS cord-309914-1lpl26eo 11 40 to to IN cord-309914-1lpl26eo 11 41 better well JJR cord-309914-1lpl26eo 11 42 44 44 CD cord-309914-1lpl26eo 11 43 understand understand VB cord-309914-1lpl26eo 11 44 the the DT cord-309914-1lpl26eo 11 45 risks risk NNS cord-309914-1lpl26eo 11 46 of of IN cord-309914-1lpl26eo 11 47 JAKi JAKi NNS cord-309914-1lpl26eo 11 48 treatment treatment NN cord-309914-1lpl26eo 11 49 in in IN cord-309914-1lpl26eo 11 50 order order NN cord-309914-1lpl26eo 11 51 to to TO cord-309914-1lpl26eo 11 52 best good JJS cord-309914-1lpl26eo 11 53 manage manage VB cord-309914-1lpl26eo 11 54 and and CC cord-309914-1lpl26eo 11 55 counsel counsel VB cord-309914-1lpl26eo 11 56 our -PRON- PRP$ cord-309914-1lpl26eo 11 57 patients patient NNS cord-309914-1lpl26eo 11 58 during during IN cord-309914-1lpl26eo 11 59 this this DT cord-309914-1lpl26eo 11 60 45 45 CD cord-309914-1lpl26eo 11 61 unique unique JJ cord-309914-1lpl26eo 11 62 time time NN cord-309914-1lpl26eo 11 63 . . . cord-309914-1lpl26eo 12 1 46 46 CD cord-309914-1lpl26eo 13 1 We -PRON- PRP cord-309914-1lpl26eo 13 2 analyzed analyze VBD cord-309914-1lpl26eo 13 3 and and CC cord-309914-1lpl26eo 13 4 collated collate VBD cord-309914-1lpl26eo 13 5 Adverse adverse JJ cord-309914-1lpl26eo 13 6 Events Events NNPS cord-309914-1lpl26eo 13 7 data datum NNS cord-309914-1lpl26eo 13 8 from from IN cord-309914-1lpl26eo 13 9 JAKi JAKi NNP cord-309914-1lpl26eo 13 10 clinical clinical JJ cord-309914-1lpl26eo 13 11 trials trial NNS cord-309914-1lpl26eo 13 12 . . . cord-309914-1lpl26eo 14 1 In in IN cord-309914-1lpl26eo 14 2 particular particular JJ cord-309914-1lpl26eo 14 3 , , , cord-309914-1lpl26eo 14 4 we -PRON- PRP cord-309914-1lpl26eo 14 5 focused focus VBD cord-309914-1lpl26eo 14 6 on on IN cord-309914-1lpl26eo 14 7 48 48 CD cord-309914-1lpl26eo 14 8 infections infection NNS cord-309914-1lpl26eo 14 9 and and CC cord-309914-1lpl26eo 14 10 pulmonary pulmonary JJ cord-309914-1lpl26eo 14 11 toxicities toxicity NNS cord-309914-1lpl26eo 14 12 observed observe VBN cord-309914-1lpl26eo 14 13 across across IN cord-309914-1lpl26eo 14 14 the the DT cord-309914-1lpl26eo 14 15 different different JJ cord-309914-1lpl26eo 14 16 FDA FDA NNP cord-309914-1lpl26eo 14 17 - - HYPH cord-309914-1lpl26eo 14 18 approved approve VBN cord-309914-1lpl26eo 14 19 JAKi JAKi NNS cord-309914-1lpl26eo 14 20 for for IN cord-309914-1lpl26eo 14 21 their -PRON- PRP$ cord-309914-1lpl26eo 14 22 FDA-49 FDA-49 NNP cord-309914-1lpl26eo 14 23 approved approve VBN cord-309914-1lpl26eo 14 24 indications indication NNS cord-309914-1lpl26eo 14 25 . . . cord-309914-1lpl26eo 15 1 When when WRB cord-309914-1lpl26eo 15 2 available available JJ cord-309914-1lpl26eo 15 3 , , , cord-309914-1lpl26eo 15 4 data datum NNS cord-309914-1lpl26eo 15 5 from from IN cord-309914-1lpl26eo 15 6 phase phase NN cord-309914-1lpl26eo 15 7 II II NNP cord-309914-1lpl26eo 15 8 or or CC cord-309914-1lpl26eo 15 9 III iii CD cord-309914-1lpl26eo 15 10 clinical clinical JJ cord-309914-1lpl26eo 15 11 trials trial NNS cord-309914-1lpl26eo 15 12 for for IN cord-309914-1lpl26eo 15 13 dermatological dermatological JJ cord-309914-1lpl26eo 15 14 50 50 CD cord-309914-1lpl26eo 15 15 indications indication NNS cord-309914-1lpl26eo 15 16 was be VBD cord-309914-1lpl26eo 15 17 included include VBN cord-309914-1lpl26eo 15 18 . . . cord-309914-1lpl26eo 16 1 Table table NN cord-309914-1lpl26eo 16 2 1 1 CD cord-309914-1lpl26eo 16 3 shows show VBZ cord-309914-1lpl26eo 16 4 the the DT cord-309914-1lpl26eo 16 5 rates rate NNS cord-309914-1lpl26eo 16 6 of of IN cord-309914-1lpl26eo 16 7 various various JJ cord-309914-1lpl26eo 16 8 infections infection NNS cord-309914-1lpl26eo 16 9 , , , cord-309914-1lpl26eo 16 10 including include VBG cord-309914-1lpl26eo 16 11 upper upper JJ cord-309914-1lpl26eo 16 12 respiratory respiratory JJ cord-309914-1lpl26eo 16 13 51 51 CD cord-309914-1lpl26eo 16 14 infections infection NNS cord-309914-1lpl26eo 16 15 , , , cord-309914-1lpl26eo 16 16 nasopharyngitis nasopharyngitis NN cord-309914-1lpl26eo 16 17 and and CC cord-309914-1lpl26eo 16 18 influenza influenza NN cord-309914-1lpl26eo 16 19 , , , cord-309914-1lpl26eo 16 20 for for IN cord-309914-1lpl26eo 16 21 JAKi JAKi NNS cord-309914-1lpl26eo 16 22 - - HYPH cord-309914-1lpl26eo 16 23 treated treat VBN cord-309914-1lpl26eo 16 24 groups group NNS cord-309914-1lpl26eo 16 25 versus versus IN cord-309914-1lpl26eo 16 26 placebo placebo NN cord-309914-1lpl26eo 16 27 groups group NNS cord-309914-1lpl26eo 16 28 . . . cord-309914-1lpl26eo 17 1 Overall overall RB cord-309914-1lpl26eo 17 2 , , , cord-309914-1lpl26eo 17 3 rates rate NNS cord-309914-1lpl26eo 17 4 52 52 CD cord-309914-1lpl26eo 17 5 of of IN cord-309914-1lpl26eo 17 6 infectious infectious JJ cord-309914-1lpl26eo 17 7 events event NNS cord-309914-1lpl26eo 17 8 are be VBP cord-309914-1lpl26eo 17 9 only only RB cord-309914-1lpl26eo 17 10 mildly mildly RB cord-309914-1lpl26eo 17 11 increased increase VBN cord-309914-1lpl26eo 17 12 in in IN cord-309914-1lpl26eo 17 13 JAKi JAKi NNS cord-309914-1lpl26eo 17 14 - - HYPH cord-309914-1lpl26eo 17 15 treated treat VBN cord-309914-1lpl26eo 17 16 patients patient NNS cord-309914-1lpl26eo 17 17 . . . cord-309914-1lpl26eo 18 1 We -PRON- PRP cord-309914-1lpl26eo 18 2 also also RB cord-309914-1lpl26eo 18 3 collated collate VBD cord-309914-1lpl26eo 18 4 pulmonary pulmonary JJ cord-309914-1lpl26eo 18 5 53 53 CD cord-309914-1lpl26eo 18 6 toxicities toxicity NNS cord-309914-1lpl26eo 18 7 of of IN cord-309914-1lpl26eo 18 8 JAKi JAKi NNS cord-309914-1lpl26eo 18 9 to to TO cord-309914-1lpl26eo 18 10 identify identify VB cord-309914-1lpl26eo 18 11 potential potential JJ cord-309914-1lpl26eo 18 12 risks risk NNS cord-309914-1lpl26eo 18 13 of of IN cord-309914-1lpl26eo 18 14 worsening worsen VBG cord-309914-1lpl26eo 18 15 severe severe JJ cord-309914-1lpl26eo 18 16 respiratory respiratory JJ cord-309914-1lpl26eo 18 17 disease disease NN cord-309914-1lpl26eo 18 18 from from IN cord-309914-1lpl26eo 18 19 SARS SARS NNP cord-309914-1lpl26eo 18 20 - - HYPH cord-309914-1lpl26eo 18 21 CoV-2 CoV-2 NNP cord-309914-1lpl26eo 18 22 , , , cord-309914-1lpl26eo 18 23 and and CC cord-309914-1lpl26eo 18 24 54 54 CD cord-309914-1lpl26eo 18 25 such such JJ cord-309914-1lpl26eo 18 26 toxicities toxicity NNS cord-309914-1lpl26eo 18 27 are be VBP cord-309914-1lpl26eo 18 28 all all RB cord-309914-1lpl26eo 18 29 but but CC cord-309914-1lpl26eo 18 30 absent absent JJ cord-309914-1lpl26eo 18 31 . . . cord-309914-1lpl26eo 19 1 55 55 CD cord-309914-1lpl26eo 19 2 56 56 CD cord-309914-1lpl26eo 20 1 In in IN cord-309914-1lpl26eo 20 2 order order NN cord-309914-1lpl26eo 20 3 to to TO cord-309914-1lpl26eo 20 4 understand understand VB cord-309914-1lpl26eo 20 5 the the DT cord-309914-1lpl26eo 20 6 infection infection NN cord-309914-1lpl26eo 20 7 data datum NNS cord-309914-1lpl26eo 20 8 , , , cord-309914-1lpl26eo 20 9 it -PRON- PRP cord-309914-1lpl26eo 20 10 is be VBZ cord-309914-1lpl26eo 20 11 helpful helpful JJ cord-309914-1lpl26eo 20 12 to to TO cord-309914-1lpl26eo 20 13 understand understand VB cord-309914-1lpl26eo 20 14 the the DT cord-309914-1lpl26eo 20 15 mechanism mechanism NN cord-309914-1lpl26eo 20 16 and and CC cord-309914-1lpl26eo 20 17 57 57 CD cord-309914-1lpl26eo 20 18 pharmacokinetics pharmacokinetic NNS cord-309914-1lpl26eo 20 19 of of IN cord-309914-1lpl26eo 20 20 JAKi JAKi NNS cord-309914-1lpl26eo 20 21 . . . cord-309914-1lpl26eo 21 1 Cytokines cytokine NNS cord-309914-1lpl26eo 21 2 can can MD cord-309914-1lpl26eo 21 3 drive drive VB cord-309914-1lpl26eo 21 4 autoimmunity autoimmunity NN cord-309914-1lpl26eo 21 5 when when WRB cord-309914-1lpl26eo 21 6 their -PRON- PRP$ cord-309914-1lpl26eo 21 7 activity activity NN cord-309914-1lpl26eo 21 8 is be VBZ cord-309914-1lpl26eo 21 9 exaggerated exaggerate VBN cord-309914-1lpl26eo 21 10 ( ( -LRB- cord-309914-1lpl26eo 21 11 Figure figure NN cord-309914-1lpl26eo 21 12 3 3 CD cord-309914-1lpl26eo 21 13 1A 1a CD cord-309914-1lpl26eo 21 14 ) ) -RRB- cord-309914-1lpl26eo 21 15 . . . cord-309914-1lpl26eo 22 1 JAKi JAKi NNP cord-309914-1lpl26eo 22 2 , , , cord-309914-1lpl26eo 22 3 which which WDT cord-309914-1lpl26eo 22 4 are be VBP cord-309914-1lpl26eo 22 5 taken take VBN cord-309914-1lpl26eo 22 6 orally orally RB cord-309914-1lpl26eo 22 7 1 1 CD cord-309914-1lpl26eo 22 8 - - SYM cord-309914-1lpl26eo 22 9 2 2 CD cord-309914-1lpl26eo 22 10 times time NNS cord-309914-1lpl26eo 22 11 per per IN cord-309914-1lpl26eo 22 12 day day NN cord-309914-1lpl26eo 22 13 , , , cord-309914-1lpl26eo 22 14 largely largely RB cord-309914-1lpl26eo 22 15 impact impact NN cord-309914-1lpl26eo 22 16 pathogenically pathogenically RB cord-309914-1lpl26eo 22 17 elevated elevated JJ cord-309914-1lpl26eo 22 18 cytokine cytokine NN cord-309914-1lpl26eo 22 19 59 59 CD cord-309914-1lpl26eo 22 20 activity activity NN cord-309914-1lpl26eo 22 21 , , , cord-309914-1lpl26eo 22 22 with with IN cord-309914-1lpl26eo 22 23 relative relative JJ cord-309914-1lpl26eo 22 24 sparing sparing NN cord-309914-1lpl26eo 22 25 of of IN cord-309914-1lpl26eo 22 26 normal normal JJ cord-309914-1lpl26eo 22 27 cytokine cytokine NN cord-309914-1lpl26eo 22 28 activity activity NN cord-309914-1lpl26eo 22 29 because because IN cord-309914-1lpl26eo 22 30 drug drug NN cord-309914-1lpl26eo 22 31 concentrations concentration NNS cord-309914-1lpl26eo 22 32 are be VBP cord-309914-1lpl26eo 22 33 sub-60 sub-60 NNP cord-309914-1lpl26eo 22 34 therapeutic therapeutic JJ cord-309914-1lpl26eo 22 35 for for IN cord-309914-1lpl26eo 22 36 part part NN cord-309914-1lpl26eo 22 37 of of IN cord-309914-1lpl26eo 22 38 the the DT cord-309914-1lpl26eo 22 39 day day NN cord-309914-1lpl26eo 22 40 ( ( -LRB- cord-309914-1lpl26eo 22 41 Figure figure NN cord-309914-1lpl26eo 22 42 1B 1b CD cord-309914-1lpl26eo 23 1 In in IN cord-309914-1lpl26eo 23 2 this this DT cord-309914-1lpl26eo 23 3 time time NN cord-309914-1lpl26eo 23 4 of of IN cord-309914-1lpl26eo 23 5 the the DT cord-309914-1lpl26eo 23 6 SARS SARS NNP cord-309914-1lpl26eo 23 7 - - HYPH cord-309914-1lpl26eo 23 8 CoV-2 CoV-2 NNP cord-309914-1lpl26eo 23 9 pandemic pandemic NN cord-309914-1lpl26eo 23 10 , , , cord-309914-1lpl26eo 23 11 we -PRON- PRP cord-309914-1lpl26eo 23 12 must must MD cord-309914-1lpl26eo 23 13 be be VB cord-309914-1lpl26eo 23 14 as as RB cord-309914-1lpl26eo 23 15 informed inform VBN cord-309914-1lpl26eo 23 16 as as IN cord-309914-1lpl26eo 23 17 possible possible JJ cord-309914-1lpl26eo 23 18 regarding regard VBG cord-309914-1lpl26eo 23 19 the the DT cord-309914-1lpl26eo 23 20 risks risk NNS cord-309914-1lpl26eo 23 21 of of IN cord-309914-1lpl26eo 23 22 the the DT cord-309914-1lpl26eo 23 23 75 75 CD cord-309914-1lpl26eo 23 24 treatments treatment NNS cord-309914-1lpl26eo 23 25 we -PRON- PRP cord-309914-1lpl26eo 23 26 prescribe prescribe VBP cord-309914-1lpl26eo 23 27 our -PRON- PRP$ cord-309914-1lpl26eo 23 28 patients patient NNS cord-309914-1lpl26eo 23 29 . . . cord-309914-1lpl26eo 24 1 Of of RB cord-309914-1lpl26eo 24 2 course course RB cord-309914-1lpl26eo 24 3 , , , cord-309914-1lpl26eo 24 4 shared share VBN cord-309914-1lpl26eo 24 5 decision decision NN cord-309914-1lpl26eo 24 6 - - HYPH cord-309914-1lpl26eo 24 7 making making NN cord-309914-1lpl26eo 24 8 reigns reign VBZ cord-309914-1lpl26eo 24 9 supreme supreme JJ cord-309914-1lpl26eo 24 10 , , , cord-309914-1lpl26eo 24 11 but but CC cord-309914-1lpl26eo 24 12 without without IN cord-309914-1lpl26eo 24 13 76 76 CD cord-309914-1lpl26eo 24 14 data datum NNS cord-309914-1lpl26eo 24 15 we -PRON- PRP cord-309914-1lpl26eo 24 16 , , , cord-309914-1lpl26eo 24 17 as as IN cord-309914-1lpl26eo 24 18 physicians physician NNS cord-309914-1lpl26eo 24 19 , , , cord-309914-1lpl26eo 24 20 will will MD cord-309914-1lpl26eo 24 21 be be VB cord-309914-1lpl26eo 24 22 unable unable JJ cord-309914-1lpl26eo 24 23 to to TO cord-309914-1lpl26eo 24 24 provide provide VB cord-309914-1lpl26eo 24 25 our -PRON- PRP$ cord-309914-1lpl26eo 24 26 patients patient NNS cord-309914-1lpl26eo 24 27 the the DT cord-309914-1lpl26eo 24 28 guidance guidance NN cord-309914-1lpl26eo 24 29 they -PRON- PRP cord-309914-1lpl26eo 24 30 rely rely VBP cord-309914-1lpl26eo 24 31 on on IN cord-309914-1lpl26eo 24 32 us -PRON- PRP cord-309914-1lpl26eo 24 33 for for IN cord-309914-1lpl26eo 24 34 . . . cord-309914-1lpl26eo 24 35 _SP cord-309914-1lpl26eo 25 1 Should Should NNP cord-309914-1lpl26eo 25 2 biologics biologic NNS cord-309914-1lpl26eo 25 3 for for IN cord-309914-1lpl26eo 25 4 psoriasis psoriasis NN cord-309914-1lpl26eo 25 5 be be VB cord-309914-1lpl26eo 25 6 interrupted interrupt VBN cord-309914-1lpl26eo 25 7 in in IN cord-309914-1lpl26eo 25 8 the the DT cord-309914-1lpl26eo 25 9 era era NN cord-309914-1lpl26eo 25 10 of of IN cord-309914-1lpl26eo 25 11 Inflammatory Inflammatory NNP cord-309914-1lpl26eo 25 12 Diseases Diseases NNPS cord-309914-1lpl26eo 25 13 liver liver NN cord-309914-1lpl26eo 25 14 abscess abscess NN cord-309914-1lpl26eo 25 15 ( ( -LRB- cord-309914-1lpl26eo 25 16 1 1 CD cord-309914-1lpl26eo 25 17 ) ) -RRB- cord-309914-1lpl26eo 25 18 , , , cord-309914-1lpl26eo 25 19 pleural pleural JJ cord-309914-1lpl26eo 25 20 effusion effusion NN cord-309914-1lpl26eo 25 21 ( ( -LRB- cord-309914-1lpl26eo 25 22 1 1 CD cord-309914-1lpl26eo 25 23 ) ) -RRB- cord-309914-1lpl26eo 25 24 , , , cord-309914-1lpl26eo 25 25 pyelonephritis pyelonephritis NN cord-309914-1lpl26eo 25 26 ( ( -LRB- cord-309914-1lpl26eo 25 27 1 1 CD cord-309914-1lpl26eo 25 28 ) ) -RRB- cord-309914-1lpl26eo 25 29 117 117 CD cord-309914-1lpl26eo 25 30 2 2 CD cord-309914-1lpl26eo 25 31 . . . cord-309914-1lpl26eo 26 1 10 10 CD cord-309914-1lpl26eo 26 2 mg mg NNP cord-309914-1lpl26eo 26 3 dose dose NN cord-309914-1lpl26eo 26 4 - - HYPH cord-309914-1lpl26eo 26 5 anal anal JJ cord-309914-1lpl26eo 26 6 abscess abscess NN cord-309914-1lpl26eo 26 7 ( ( -LRB- cord-309914-1lpl26eo 26 8 1 1 CD cord-309914-1lpl26eo 26 9 ) ) -RRB- cord-309914-1lpl26eo 26 10 , , , cord-309914-1lpl26eo 26 11 cellulitis cellulitis NN cord-309914-1lpl26eo 26 12 ( ( -LRB- cord-309914-1lpl26eo 26 13 1 1 CD cord-309914-1lpl26eo 26 14 ) ) -RRB- cord-309914-1lpl26eo 26 15 , , , cord-309914-1lpl26eo 26 16 febrile febrile JJ cord-309914-1lpl26eo 26 17 infection infection NN cord-309914-1lpl26eo 26 18 ( ( -LRB- cord-309914-1lpl26eo 26 19 1 1 CD cord-309914-1lpl26eo 26 20 ) ) -RRB- cord-309914-1lpl26eo 26 21 , , , cord-309914-1lpl26eo 26 22 otitis otitis NN cord-309914-1lpl26eo 26 23 externa externa NNS cord-309914-1lpl26eo 26 24 ( ( -LRB- cord-309914-1lpl26eo 26 25 1 1 CD cord-309914-1lpl26eo 26 26 ) ) -RRB- cord-309914-1lpl26eo 26 27 , , , cord-309914-1lpl26eo 26 28 pneumonia pneumonia NN cord-309914-1lpl26eo 26 29 ( ( -LRB- cord-309914-1lpl26eo 26 30 1 1 CD cord-309914-1lpl26eo 26 31 ) ) -RRB- cord-309914-1lpl26eo 26 32 118 118 CD cord-309914-1lpl26eo 26 33 3 3 CD cord-309914-1lpl26eo 26 34 . . . cord-309914-1lpl26eo 27 1 10 10 CD cord-309914-1lpl26eo 27 2 mg mg NNP cord-309914-1lpl26eo 27 3 dose dose NN cord-309914-1lpl26eo 27 4 -furuncle -furuncle NNP cord-309914-1lpl26eo 27 5 ( ( -LRB- cord-309914-1lpl26eo 27 6 1 1 CD cord-309914-1lpl26eo 27 7 ) ) -RRB- cord-309914-1lpl26eo 27 8 119 119 CD cord-309914-1lpl26eo 27 9 4 4 CD cord-309914-1lpl26eo 27 10 . . . cord-309914-1lpl26eo 28 1 1 1 CD cord-309914-1lpl26eo 28 2 mg mg NN cord-309914-1lpl26eo 28 3 dose dose NN cord-309914-1lpl26eo 28 4 -peri -peri NN cord-309914-1lpl26eo 28 5 - - HYPH cord-309914-1lpl26eo 28 6 tonsillitis tonsillitis NN cord-309914-1lpl26eo 28 7 PNA PNA NNP cord-309914-1lpl26eo 28 8 ( ( -LRB- cord-309914-1lpl26eo 28 9 8) 8) NNP cord-309914-1lpl26eo 28 10 , , , cord-309914-1lpl26eo 28 11 122 122 CD cord-309914-1lpl26eo 28 12 sinusitis sinusitis NN cord-309914-1lpl26eo 28 13 ( ( -LRB- cord-309914-1lpl26eo 28 14 1 1 CD cord-309914-1lpl26eo 28 15 ) ) -RRB- cord-309914-1lpl26eo 28 16 , , , cord-309914-1lpl26eo 28 17 sepsis sepsis NN cord-309914-1lpl26eo 28 18 ( ( -LRB- cord-309914-1lpl26eo 28 19 1 1 CD cord-309914-1lpl26eo 28 20 ) ) -RRB- cord-309914-1lpl26eo 28 21 , , , cord-309914-1lpl26eo 28 22 lower low JJR cord-309914-1lpl26eo 28 23 respiratory respiratory JJ cord-309914-1lpl26eo 28 24 infection infection NN cord-309914-1lpl26eo 28 25 ( ( -LRB- cord-309914-1lpl26eo 28 26 1 1 CD cord-309914-1lpl26eo 28 27 ) ) -RRB- cord-309914-1lpl26eo 28 28 123 123 CD cord-309914-1lpl26eo 28 29 7 7 CD cord-309914-1lpl26eo 28 30 . . . cord-309914-1lpl26eo 29 1 15 15 CD cord-309914-1lpl26eo 29 2 mg mg NN cord-309914-1lpl26eo 29 3 dose dose NN cord-309914-1lpl26eo 29 4 - - HYPH cord-309914-1lpl26eo 29 5 viral viral JJ cord-309914-1lpl26eo 29 6 infection infection NN cord-309914-1lpl26eo 29 7 ( ( -LRB- cord-309914-1lpl26eo 29 8 1 1 CD cord-309914-1lpl26eo 29 9 ) ) -RRB-