id sid tid token lemma pos cord-286132-ag2l1xa7 1 1 key key NNP cord-286132-ag2l1xa7 1 2 : : : cord-286132-ag2l1xa7 1 3 cord-286132-ag2l1xa7 cord-286132-ag2l1xa7 NNS cord-286132-ag2l1xa7 1 4 authors author NNS cord-286132-ag2l1xa7 1 5 : : : cord-286132-ag2l1xa7 1 6 Akiyama Akiyama NNP cord-286132-ag2l1xa7 1 7 , , , cord-286132-ag2l1xa7 1 8 Shintaro Shintaro NNP cord-286132-ag2l1xa7 1 9 ; ; : cord-286132-ag2l1xa7 1 10 Yamada Yamada NNP cord-286132-ag2l1xa7 1 11 , , , cord-286132-ag2l1xa7 1 12 Akihiro Akihiro NNP cord-286132-ag2l1xa7 1 13 ; ; : cord-286132-ag2l1xa7 1 14 Micic Micic NNP cord-286132-ag2l1xa7 1 15 , , , cord-286132-ag2l1xa7 1 16 Dejan Dejan NNP cord-286132-ag2l1xa7 1 17 ; ; : cord-286132-ag2l1xa7 1 18 Sakuraba Sakuraba NNP cord-286132-ag2l1xa7 1 19 , , , cord-286132-ag2l1xa7 2 1 Atsushi Atsushi NNP cord-286132-ag2l1xa7 2 2 title title NN cord-286132-ag2l1xa7 2 3 : : : cord-286132-ag2l1xa7 3 1 The the DT cord-286132-ag2l1xa7 3 2 risk risk NN cord-286132-ag2l1xa7 3 3 of of IN cord-286132-ag2l1xa7 3 4 respiratory respiratory JJ cord-286132-ag2l1xa7 3 5 tract tract NN cord-286132-ag2l1xa7 3 6 infections infection NNS cord-286132-ag2l1xa7 3 7 and and CC cord-286132-ag2l1xa7 3 8 interstitial interstitial JJ cord-286132-ag2l1xa7 3 9 lung lung NN cord-286132-ag2l1xa7 3 10 disease disease NN cord-286132-ag2l1xa7 3 11 with with IN cord-286132-ag2l1xa7 3 12 IL-12/23 IL-12/23 NNP cord-286132-ag2l1xa7 3 13 and and CC cord-286132-ag2l1xa7 3 14 IL-23 IL-23 NNP cord-286132-ag2l1xa7 3 15 antagonists antagonist NNS cord-286132-ag2l1xa7 3 16 in in IN cord-286132-ag2l1xa7 3 17 patients patient NNS cord-286132-ag2l1xa7 3 18 with with IN cord-286132-ag2l1xa7 3 19 autoimmune autoimmune JJ cord-286132-ag2l1xa7 3 20 diseases disease NNS cord-286132-ag2l1xa7 3 21 : : : cord-286132-ag2l1xa7 3 22 a a DT cord-286132-ag2l1xa7 3 23 systematic systematic JJ cord-286132-ag2l1xa7 3 24 review review NN cord-286132-ag2l1xa7 3 25 and and CC cord-286132-ag2l1xa7 3 26 meta meta NN cord-286132-ag2l1xa7 3 27 - - HYPH cord-286132-ag2l1xa7 3 28 analysis analysis NN cord-286132-ag2l1xa7 3 29 date date NN cord-286132-ag2l1xa7 3 30 : : : cord-286132-ag2l1xa7 3 31 2020 2020 CD cord-286132-ag2l1xa7 3 32 - - HYPH cord-286132-ag2l1xa7 3 33 08 08 CD cord-286132-ag2l1xa7 3 34 - - HYPH cord-286132-ag2l1xa7 3 35 11 11 CD cord-286132-ag2l1xa7 3 36 journal journal NN cord-286132-ag2l1xa7 3 37 : : : cord-286132-ag2l1xa7 3 38 J J NNP cord-286132-ag2l1xa7 3 39 Am Am NNP cord-286132-ag2l1xa7 3 40 Acad Acad NNP cord-286132-ag2l1xa7 3 41 Dermatol Dermatol NNP cord-286132-ag2l1xa7 4 1 DOI DOI NNP cord-286132-ag2l1xa7 4 2 : : : cord-286132-ag2l1xa7 5 1 10.1016 10.1016 CD cord-286132-ag2l1xa7 5 2 / / SYM cord-286132-ag2l1xa7 5 3 j.jaad.2020.08.026 j.jaad.2020.08.026 NNP cord-286132-ag2l1xa7 5 4 sha sha NNP cord-286132-ag2l1xa7 5 5 : : : cord-286132-ag2l1xa7 6 1 83897f590cb4747442ca2dbc4274f37425dbd352 83897f590cb4747442ca2dbc4274f37425dbd352 NFP cord-286132-ag2l1xa7 6 2 doc_id doc_id CD cord-286132-ag2l1xa7 6 3 : : : cord-286132-ag2l1xa7 6 4 286132 286132 CD cord-286132-ag2l1xa7 6 5 cord_uid cord_uid NNS cord-286132-ag2l1xa7 6 6 : : : cord-286132-ag2l1xa7 7 1 ag2l1xa7 ag2l1xa7 UH cord-286132-ag2l1xa7 7 2 Abstract Abstract NNP cord-286132-ag2l1xa7 7 3 Background Background NNP cord-286132-ag2l1xa7 7 4 Respiratory respiratory JJ cord-286132-ag2l1xa7 7 5 tract tract NN cord-286132-ag2l1xa7 7 6 infections infection NNS cord-286132-ag2l1xa7 7 7 ( ( -LRB- cord-286132-ag2l1xa7 7 8 RTIs rti NNS cord-286132-ag2l1xa7 7 9 ) ) -RRB- cord-286132-ag2l1xa7 7 10 and and CC cord-286132-ag2l1xa7 7 11 interstitial interstitial JJ cord-286132-ag2l1xa7 7 12 lung lung NN cord-286132-ag2l1xa7 7 13 disease disease NN cord-286132-ag2l1xa7 7 14 ( ( -LRB- cord-286132-ag2l1xa7 7 15 ILD ILD NNP cord-286132-ag2l1xa7 7 16 ) ) -RRB- cord-286132-ag2l1xa7 7 17 secondary secondary JJ cord-286132-ag2l1xa7 7 18 to to IN cord-286132-ag2l1xa7 7 19 interleukin interleukin NN cord-286132-ag2l1xa7 7 20 ( ( -LRB- cord-286132-ag2l1xa7 7 21 IL)-12/23 IL)-12/23 NNP cord-286132-ag2l1xa7 7 22 or or CC cord-286132-ag2l1xa7 7 23 IL-23 IL-23 NNP cord-286132-ag2l1xa7 7 24 antagonists antagonist NNS cord-286132-ag2l1xa7 7 25 have have VBP cord-286132-ag2l1xa7 7 26 been be VBN cord-286132-ag2l1xa7 7 27 reported report VBN cord-286132-ag2l1xa7 7 28 in in IN cord-286132-ag2l1xa7 7 29 autoimmune autoimmune JJ cord-286132-ag2l1xa7 7 30 diseases disease NNS cord-286132-ag2l1xa7 7 31 . . . cord-286132-ag2l1xa7 8 1 Objective objective JJ cord-286132-ag2l1xa7 9 1 To to TO cord-286132-ag2l1xa7 9 2 assess assess VB cord-286132-ag2l1xa7 9 3 the the DT cord-286132-ag2l1xa7 9 4 risk risk NN cord-286132-ag2l1xa7 9 5 of of IN cord-286132-ag2l1xa7 9 6 RTIs rti NNS cord-286132-ag2l1xa7 9 7 and and CC cord-286132-ag2l1xa7 9 8 non non JJ cord-286132-ag2l1xa7 9 9 - - JJ cord-286132-ag2l1xa7 9 10 infectious infectious JJ cord-286132-ag2l1xa7 9 11 ILD ild NN cord-286132-ag2l1xa7 9 12 with with IN cord-286132-ag2l1xa7 9 13 these these DT cord-286132-ag2l1xa7 9 14 drugs drug NNS cord-286132-ag2l1xa7 9 15 . . . cord-286132-ag2l1xa7 10 1 Methods method NNS cord-286132-ag2l1xa7 11 1 We -PRON- PRP cord-286132-ag2l1xa7 11 2 conducted conduct VBD cord-286132-ag2l1xa7 11 3 a a DT cord-286132-ag2l1xa7 11 4 systematic systematic JJ cord-286132-ag2l1xa7 11 5 review review NN cord-286132-ag2l1xa7 11 6 and and CC cord-286132-ag2l1xa7 11 7 meta meta NNP cord-286132-ag2l1xa7 11 8 - - HYPH cord-286132-ag2l1xa7 11 9 analysis analysis NN cord-286132-ag2l1xa7 11 10 of of IN cord-286132-ag2l1xa7 11 11 randomized randomized JJ cord-286132-ag2l1xa7 11 12 controlled control VBN cord-286132-ag2l1xa7 11 13 trials trial NNS cord-286132-ag2l1xa7 11 14 ( ( -LRB- cord-286132-ag2l1xa7 11 15 RCTs RCTs NNP cord-286132-ag2l1xa7 11 16 ) ) -RRB- cord-286132-ag2l1xa7 11 17 . . . cord-286132-ag2l1xa7 12 1 Risk risk NN cord-286132-ag2l1xa7 12 2 of of IN cord-286132-ag2l1xa7 12 3 RTIs rti NNS cord-286132-ag2l1xa7 12 4 and and CC cord-286132-ag2l1xa7 12 5 non non JJ cord-286132-ag2l1xa7 12 6 - - JJ cord-286132-ag2l1xa7 12 7 infectious infectious JJ cord-286132-ag2l1xa7 12 8 ILD ILD NNP cord-286132-ag2l1xa7 12 9 was be VBD cord-286132-ag2l1xa7 12 10 compared compare VBN cord-286132-ag2l1xa7 12 11 to to IN cord-286132-ag2l1xa7 12 12 placebo placebo NN cord-286132-ag2l1xa7 12 13 by by IN cord-286132-ag2l1xa7 12 14 Mantel Mantel NNP cord-286132-ag2l1xa7 12 15 - - HYPH cord-286132-ag2l1xa7 12 16 Haenszel Haenszel NNP cord-286132-ag2l1xa7 12 17 ( ( -LRB- cord-286132-ag2l1xa7 12 18 MH MH NNP cord-286132-ag2l1xa7 12 19 ) ) -RRB- cord-286132-ag2l1xa7 12 20 risk risk NN cord-286132-ag2l1xa7 12 21 difference difference NN cord-286132-ag2l1xa7 12 22 ( ( -LRB- cord-286132-ag2l1xa7 12 23 RD RD NNP cord-286132-ag2l1xa7 12 24 ) ) -RRB- cord-286132-ag2l1xa7 12 25 . . . cord-286132-ag2l1xa7 13 1 We -PRON- PRP cord-286132-ag2l1xa7 13 2 divided divide VBD cord-286132-ag2l1xa7 13 3 RTIs rti NNS cord-286132-ag2l1xa7 13 4 into into IN cord-286132-ag2l1xa7 13 5 upper upper JJ cord-286132-ag2l1xa7 13 6 RTIs rti NNS cord-286132-ag2l1xa7 13 7 ( ( -LRB- cord-286132-ag2l1xa7 13 8 URTI URTI NNP cord-286132-ag2l1xa7 13 9 ) ) -RRB- cord-286132-ag2l1xa7 13 10 , , , cord-286132-ag2l1xa7 13 11 viral viral JJ cord-286132-ag2l1xa7 13 12 URTIs urti NNS cord-286132-ag2l1xa7 13 13 , , , cord-286132-ag2l1xa7 13 14 and and CC cord-286132-ag2l1xa7 13 15 lower low JJR cord-286132-ag2l1xa7 13 16 RTIs rti NNS cord-286132-ag2l1xa7 13 17 ( ( -LRB- cord-286132-ag2l1xa7 13 18 LRTIs LRTIs NNP cord-286132-ag2l1xa7 13 19 ) ) -RRB- cord-286132-ag2l1xa7 13 20 including include VBG cord-286132-ag2l1xa7 13 21 infectious infectious JJ cord-286132-ag2l1xa7 13 22 pneumonia pneumonia NN cord-286132-ag2l1xa7 13 23 . . . cord-286132-ag2l1xa7 14 1 Non non JJ cord-286132-ag2l1xa7 14 2 - - JJ cord-286132-ag2l1xa7 14 3 infectious infectious JJ cord-286132-ag2l1xa7 14 4 ILD ILD NNP cord-286132-ag2l1xa7 14 5 included include VBD cord-286132-ag2l1xa7 14 6 ILD ILD NNP cord-286132-ag2l1xa7 14 7 , , , cord-286132-ag2l1xa7 14 8 eosinophilic eosinophilic JJ cord-286132-ag2l1xa7 14 9 pneumonia pneumonia NN cord-286132-ag2l1xa7 14 10 , , , cord-286132-ag2l1xa7 14 11 and and CC cord-286132-ag2l1xa7 14 12 pneumonitis pneumonitis NN cord-286132-ag2l1xa7 14 13 . . . cord-286132-ag2l1xa7 15 1 Results result NNS cord-286132-ag2l1xa7 16 1 We -PRON- PRP cord-286132-ag2l1xa7 16 2 identified identify VBD cord-286132-ag2l1xa7 16 3 54 54 CD cord-286132-ag2l1xa7 16 4 RCTs rct NNS cord-286132-ag2l1xa7 16 5 including include VBG cord-286132-ag2l1xa7 16 6 10,907 10,907 CD cord-286132-ag2l1xa7 16 7 patients patient NNS cord-286132-ag2l1xa7 16 8 with with IN cord-286132-ag2l1xa7 16 9 six six CD cord-286132-ag2l1xa7 16 10 IL-12/23 il-12/23 NN cord-286132-ag2l1xa7 16 11 or or CC cord-286132-ag2l1xa7 16 12 IL-23 IL-23 NNP cord-286132-ag2l1xa7 16 13 antagonists antagonist NNS cord-286132-ag2l1xa7 16 14 and and CC cord-286132-ag2l1xa7 16 15 5,175 5,175 CD cord-286132-ag2l1xa7 16 16 patients patient NNS cord-286132-ag2l1xa7 16 17 with with IN cord-286132-ag2l1xa7 16 18 placebo placebo NN cord-286132-ag2l1xa7 16 19 . . . cord-286132-ag2l1xa7 17 1 These these DT cord-286132-ag2l1xa7 17 2 drugs drug NNS cord-286132-ag2l1xa7 17 3 significantly significantly RB cord-286132-ag2l1xa7 17 4 increased increase VBD cord-286132-ag2l1xa7 17 5 the the DT cord-286132-ag2l1xa7 17 6 risk risk NN cord-286132-ag2l1xa7 17 7 of of IN cord-286132-ag2l1xa7 17 8 RTIs rti NNS cord-286132-ag2l1xa7 17 9 ( ( -LRB- cord-286132-ag2l1xa7 17 10 MH MH NNP cord-286132-ag2l1xa7 17 11 RD RD NNP cord-286132-ag2l1xa7 17 12 0.019 0.019 CD cord-286132-ag2l1xa7 17 13 , , , cord-286132-ag2l1xa7 17 14 95 95 CD cord-286132-ag2l1xa7 17 15 % % NN cord-286132-ag2l1xa7 17 16 confidence confidence NN cord-286132-ag2l1xa7 17 17 interval interval NN cord-286132-ag2l1xa7 17 18 0.005 0.005 CD cord-286132-ag2l1xa7 17 19 - - HYPH cord-286132-ag2l1xa7 17 20 0.033 0.033 CD cord-286132-ag2l1xa7 17 21 , , , cord-286132-ag2l1xa7 17 22 P p NN cord-286132-ag2l1xa7 17 23 = = SYM cord-286132-ag2l1xa7 17 24 0.007 0.007 CD cord-286132-ag2l1xa7 17 25 ) ) -RRB- cord-286132-ag2l1xa7 17 26 which which WDT cord-286132-ag2l1xa7 17 27 was be VBD cord-286132-ag2l1xa7 17 28 attributed attribute VBN cord-286132-ag2l1xa7 17 29 to to IN cord-286132-ag2l1xa7 17 30 URTIs urti NNS cord-286132-ag2l1xa7 17 31 , , , cord-286132-ag2l1xa7 17 32 but but CC cord-286132-ag2l1xa7 17 33 not not RB cord-286132-ag2l1xa7 17 34 viral viral JJ cord-286132-ag2l1xa7 17 35 URTIs urti NNS cord-286132-ag2l1xa7 17 36 or or CC cord-286132-ag2l1xa7 17 37 LRTIs lrti NNS cord-286132-ag2l1xa7 17 38 . . . cord-286132-ag2l1xa7 18 1 There there EX cord-286132-ag2l1xa7 18 2 was be VBD cord-286132-ag2l1xa7 18 3 no no DT cord-286132-ag2l1xa7 18 4 significant significant JJ cord-286132-ag2l1xa7 18 5 difference difference NN cord-286132-ag2l1xa7 18 6 in in IN cord-286132-ag2l1xa7 18 7 infectious infectious JJ cord-286132-ag2l1xa7 18 8 pneumonia pneumonia NN cord-286132-ag2l1xa7 18 9 and and CC cord-286132-ag2l1xa7 18 10 non non JJ cord-286132-ag2l1xa7 18 11 - - JJ cord-286132-ag2l1xa7 18 12 infectious infectious JJ cord-286132-ag2l1xa7 18 13 ILD ild NN cord-286132-ag2l1xa7 18 14 between between IN cord-286132-ag2l1xa7 18 15 two two CD cord-286132-ag2l1xa7 18 16 groups group NNS cord-286132-ag2l1xa7 18 17 . . . cord-286132-ag2l1xa7 19 1 Limitations limitation NNS cord-286132-ag2l1xa7 20 1 Due due IN cord-286132-ag2l1xa7 20 2 to to IN cord-286132-ag2l1xa7 20 3 the the DT cord-286132-ag2l1xa7 20 4 rarity rarity NN cord-286132-ag2l1xa7 20 5 of of IN cord-286132-ag2l1xa7 20 6 infectious infectious JJ cord-286132-ag2l1xa7 20 7 pneumonia pneumonia NN cord-286132-ag2l1xa7 20 8 and and CC cord-286132-ag2l1xa7 20 9 ILD ILD NNP cord-286132-ag2l1xa7 20 10 , , , cord-286132-ag2l1xa7 20 11 sensitivity sensitivity NN cord-286132-ag2l1xa7 20 12 analysis analysis NN cord-286132-ag2l1xa7 20 13 was be VBD cord-286132-ag2l1xa7 20 14 required require VBN cord-286132-ag2l1xa7 20 15 . . . cord-286132-ag2l1xa7 21 1 Conclusion conclusion NN cord-286132-ag2l1xa7 22 1 The the DT cord-286132-ag2l1xa7 22 2 use use NN cord-286132-ag2l1xa7 22 3 of of IN cord-286132-ag2l1xa7 22 4 IL-12/23 il-12/23 NN cord-286132-ag2l1xa7 22 5 or or CC cord-286132-ag2l1xa7 22 6 IL-23 IL-23 NNP cord-286132-ag2l1xa7 22 7 antagonists antagonist NNS cord-286132-ag2l1xa7 22 8 for for IN cord-286132-ag2l1xa7 22 9 autoimmune autoimmune JJ cord-286132-ag2l1xa7 22 10 diseases disease NNS cord-286132-ag2l1xa7 22 11 increased increase VBD cord-286132-ag2l1xa7 22 12 the the DT cord-286132-ag2l1xa7 22 13 risk risk NN cord-286132-ag2l1xa7 22 14 of of IN cord-286132-ag2l1xa7 22 15 URTIs urti NNS cord-286132-ag2l1xa7 22 16 , , , cord-286132-ag2l1xa7 22 17 but but CC cord-286132-ag2l1xa7 22 18 not not RB cord-286132-ag2l1xa7 22 19 viral viral JJ cord-286132-ag2l1xa7 22 20 URTIs urti NNS cord-286132-ag2l1xa7 22 21 , , , cord-286132-ag2l1xa7 22 22 LRTIs lrti NNS cord-286132-ag2l1xa7 22 23 , , , cord-286132-ag2l1xa7 22 24 and and CC cord-286132-ag2l1xa7 22 25 non non JJ cord-286132-ag2l1xa7 22 26 - - JJ cord-286132-ag2l1xa7 22 27 infectious infectious JJ cord-286132-ag2l1xa7 22 28 ILD ILD NNP cord-286132-ag2l1xa7 22 29 . . . cord-286132-ag2l1xa7 23 1 The the DT cord-286132-ag2l1xa7 23 2 clinical clinical JJ cord-286132-ag2l1xa7 23 3 benefit benefit NN cord-286132-ag2l1xa7 23 4 of of IN cord-286132-ag2l1xa7 23 5 interleukin interleukin NN cord-286132-ag2l1xa7 23 6 ( ( -LRB- cord-286132-ag2l1xa7 23 7 IL)-12 il)-12 NN cord-286132-ag2l1xa7 23 8 and and CC cord-286132-ag2l1xa7 23 9 IL-23 IL-23 NNP cord-286132-ag2l1xa7 23 10 inhibition inhibition NN cord-286132-ag2l1xa7 23 11 has have VBZ cord-286132-ag2l1xa7 23 12 been be VBN cord-286132-ag2l1xa7 23 13 demonstrated demonstrate VBN cord-286132-ag2l1xa7 23 14 in in IN cord-286132-ag2l1xa7 23 15 psoriasis psoriasis NN cord-286132-ag2l1xa7 23 16 2 2 CD cord-286132-ag2l1xa7 23 17 and and CC cord-286132-ag2l1xa7 23 18 Crohn Crohn NNP cord-286132-ag2l1xa7 23 19 's 's POS cord-286132-ag2l1xa7 23 20 disease disease NN cord-286132-ag2l1xa7 23 21 ( ( -LRB- cord-286132-ag2l1xa7 23 22 CD CD NNP cord-286132-ag2l1xa7 23 23 ) ) -RRB- cord-286132-ag2l1xa7 23 24 by by IN cord-286132-ag2l1xa7 23 25 briakinumab briakinumab NN cord-286132-ag2l1xa7 23 26 1 1 CD cord-286132-ag2l1xa7 23 27 , , , cord-286132-ag2l1xa7 23 28 2 2 CD cord-286132-ag2l1xa7 23 29 or or CC cord-286132-ag2l1xa7 23 30 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 23 31 . . . cord-286132-ag2l1xa7 24 1 3 3 CD cord-286132-ag2l1xa7 24 2 , , , cord-286132-ag2l1xa7 24 3 4 4 CD cord-286132-ag2l1xa7 25 1 Furthermore furthermore RB cord-286132-ag2l1xa7 25 2 , , , cord-286132-ag2l1xa7 25 3 IL-23-specific IL-23-specific NNP cord-286132-ag2l1xa7 25 4 antagonists antagonist NNS cord-286132-ag2l1xa7 25 5 , , , cord-286132-ag2l1xa7 25 6 such such JJ cord-286132-ag2l1xa7 25 7 3 3 CD cord-286132-ag2l1xa7 25 8 as as IN cord-286132-ag2l1xa7 25 9 tildrakizumab tildrakizumab NNP cord-286132-ag2l1xa7 25 10 , , , cord-286132-ag2l1xa7 25 11 5 5 CD cord-286132-ag2l1xa7 25 12 , , , cord-286132-ag2l1xa7 25 13 6 6 CD cord-286132-ag2l1xa7 25 14 risankizumab risankizumab NNS cord-286132-ag2l1xa7 25 15 , , , cord-286132-ag2l1xa7 25 16 7 7 CD cord-286132-ag2l1xa7 25 17 , , , cord-286132-ag2l1xa7 25 18 8 8 CD cord-286132-ag2l1xa7 25 19 guselkumab guselkumab NNS cord-286132-ag2l1xa7 25 20 , , , cord-286132-ag2l1xa7 25 21 9 9 CD cord-286132-ag2l1xa7 25 22 , , , cord-286132-ag2l1xa7 25 23 10 10 CD cord-286132-ag2l1xa7 25 24 and and CC cord-286132-ag2l1xa7 25 25 brazikumab brazikumab NNP cord-286132-ag2l1xa7 25 26 , , , cord-286132-ag2l1xa7 25 27 11 11 CD cord-286132-ag2l1xa7 25 28 have have VBP cord-286132-ag2l1xa7 25 29 completed complete VBN cord-286132-ag2l1xa7 25 30 phase phase NN cord-286132-ag2l1xa7 25 31 2 2 CD cord-286132-ag2l1xa7 25 32 or or CC cord-286132-ag2l1xa7 25 33 3 3 CD cord-286132-ag2l1xa7 25 34 trials trial NNS cord-286132-ag2l1xa7 25 35 . . . cord-286132-ag2l1xa7 26 1 4 4 LS cord-286132-ag2l1xa7 27 1 Currently currently RB cord-286132-ag2l1xa7 27 2 , , , cord-286132-ag2l1xa7 27 3 IL-12/23 IL-12/23 NNP cord-286132-ag2l1xa7 27 4 or or CC cord-286132-ag2l1xa7 27 5 IL-23 IL-23 NNP cord-286132-ag2l1xa7 27 6 antagonists antagonist NNS cord-286132-ag2l1xa7 27 7 are be VBP cord-286132-ag2l1xa7 27 8 the the DT cord-286132-ag2l1xa7 27 9 second second JJ cord-286132-ag2l1xa7 27 10 most most RBS cord-286132-ag2l1xa7 27 11 commonly commonly RB cord-286132-ag2l1xa7 27 12 prescribed prescribe VBN cord-286132-ag2l1xa7 27 13 category category NN cord-286132-ag2l1xa7 27 14 of of IN cord-286132-ag2l1xa7 27 15 biologics biologic NNS cord-286132-ag2l1xa7 27 16 for for IN cord-286132-ag2l1xa7 27 17 5 5 CD cord-286132-ag2l1xa7 27 18 psoriasis psoriasis NN cord-286132-ag2l1xa7 27 19 and and CC cord-286132-ag2l1xa7 27 20 CD CD NNP cord-286132-ag2l1xa7 27 21 , , , cord-286132-ag2l1xa7 27 22 behind behind IN cord-286132-ag2l1xa7 27 23 anti anti JJ cord-286132-ag2l1xa7 27 24 - - JJ cord-286132-ag2l1xa7 27 25 tumor tumor JJ cord-286132-ag2l1xa7 27 26 necrosis necrosis NN cord-286132-ag2l1xa7 27 27 factor factor NN cord-286132-ag2l1xa7 27 28 agents agent NNS cord-286132-ag2l1xa7 27 29 . . . cord-286132-ag2l1xa7 28 1 12 12 CD cord-286132-ag2l1xa7 28 2 6 6 CD cord-286132-ag2l1xa7 28 3 However however RB cord-286132-ag2l1xa7 28 4 , , , cord-286132-ag2l1xa7 28 5 randomized randomized JJ cord-286132-ag2l1xa7 28 6 controlled control VBN cord-286132-ag2l1xa7 28 7 trials trial NNS cord-286132-ag2l1xa7 28 8 ( ( -LRB- cord-286132-ag2l1xa7 28 9 RCTs RCTs NNP cord-286132-ag2l1xa7 28 10 ) ) -RRB- cord-286132-ag2l1xa7 28 11 of of IN cord-286132-ag2l1xa7 28 12 these these DT cord-286132-ag2l1xa7 28 13 drugs drug NNS cord-286132-ag2l1xa7 28 14 reported report VBD cord-286132-ag2l1xa7 28 15 respiratory respiratory JJ cord-286132-ag2l1xa7 28 16 tract tract NN cord-286132-ag2l1xa7 28 17 infections infection NNS cord-286132-ag2l1xa7 28 18 7 7 CD cord-286132-ag2l1xa7 29 1 ( ( -LRB- cord-286132-ag2l1xa7 29 2 RTIs RTIs NNP cord-286132-ag2l1xa7 29 3 ) ) -RRB- cord-286132-ag2l1xa7 29 4 as as IN cord-286132-ag2l1xa7 29 5 the the DT cord-286132-ag2l1xa7 29 6 most most RBS cord-286132-ag2l1xa7 29 7 common common JJ cord-286132-ag2l1xa7 29 8 adverse adverse JJ cord-286132-ag2l1xa7 29 9 events event NNS cord-286132-ag2l1xa7 29 10 . . . cord-286132-ag2l1xa7 30 1 13 13 CD cord-286132-ag2l1xa7 31 1 Furthermore furthermore RB cord-286132-ag2l1xa7 31 2 , , , cord-286132-ag2l1xa7 31 3 the the DT cord-286132-ag2l1xa7 31 4 surveillance surveillance NN cord-286132-ag2l1xa7 31 5 conducted conduct VBN cord-286132-ag2l1xa7 31 6 by by IN cord-286132-ag2l1xa7 31 7 Food Food NNP cord-286132-ag2l1xa7 31 8 and and CC cord-286132-ag2l1xa7 31 9 Drug Drug NNP cord-286132-ag2l1xa7 31 10 8 8 NNP cord-286132-ag2l1xa7 31 11 Administration Administration NNP cord-286132-ag2l1xa7 31 12 ( ( -LRB- cord-286132-ag2l1xa7 31 13 FDA FDA NNP cord-286132-ag2l1xa7 31 14 ) ) -RRB- cord-286132-ag2l1xa7 31 15 reported report VBD cord-286132-ag2l1xa7 31 16 the the DT cord-286132-ag2l1xa7 31 17 development development NN cord-286132-ag2l1xa7 31 18 of of IN cord-286132-ag2l1xa7 31 19 non non JJ cord-286132-ag2l1xa7 31 20 - - JJ cord-286132-ag2l1xa7 31 21 infectious infectious JJ cord-286132-ag2l1xa7 31 22 interstitial interstitial JJ cord-286132-ag2l1xa7 31 23 lung lung NN cord-286132-ag2l1xa7 31 24 disease disease NN cord-286132-ag2l1xa7 31 25 ( ( -LRB- cord-286132-ag2l1xa7 31 26 ILD ILD NNP cord-286132-ag2l1xa7 31 27 ) ) -RRB- cord-286132-ag2l1xa7 31 28 following follow VBG cord-286132-ag2l1xa7 31 29 9 9 CD cord-286132-ag2l1xa7 31 30 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 31 31 . . . cord-286132-ag2l1xa7 32 1 14 14 CD cord-286132-ag2l1xa7 33 1 Hence hence RB cord-286132-ag2l1xa7 33 2 , , , cord-286132-ag2l1xa7 33 3 physicians physician NNS cord-286132-ag2l1xa7 33 4 need need VBP cord-286132-ag2l1xa7 33 5 evidences evidence NNS cord-286132-ag2l1xa7 33 6 to to TO cord-286132-ag2l1xa7 33 7 decide decide VB cord-286132-ag2l1xa7 33 8 whether whether IN cord-286132-ag2l1xa7 33 9 to to TO cord-286132-ag2l1xa7 33 10 continue continue VB cord-286132-ag2l1xa7 33 11 or or CC cord-286132-ag2l1xa7 33 12 hold hold VB cord-286132-ag2l1xa7 33 13 these these DT cord-286132-ag2l1xa7 33 14 drugs drug NNS cord-286132-ag2l1xa7 33 15 10 10 CD cord-286132-ag2l1xa7 33 16 particularly particularly RB cord-286132-ag2l1xa7 33 17 during during IN cord-286132-ag2l1xa7 33 18 the the DT cord-286132-ag2l1xa7 33 19 current current JJ cord-286132-ag2l1xa7 33 20 COVID-19 COVID-19 NNP cord-286132-ag2l1xa7 33 21 pandemic pandemic NN cord-286132-ag2l1xa7 33 22 . . . cord-286132-ag2l1xa7 34 1 15 15 CD cord-286132-ag2l1xa7 34 2 - - SYM cord-286132-ag2l1xa7 34 3 17 17 CD cord-286132-ag2l1xa7 34 4 11 11 CD cord-286132-ag2l1xa7 34 5 This this DT cord-286132-ag2l1xa7 34 6 systematic systematic JJ cord-286132-ag2l1xa7 34 7 review review NN cord-286132-ag2l1xa7 34 8 and and CC cord-286132-ag2l1xa7 34 9 meta meta NNP cord-286132-ag2l1xa7 34 10 - - HYPH cord-286132-ag2l1xa7 34 11 analysis analysis NN cord-286132-ag2l1xa7 34 12 aimed aim VBN cord-286132-ag2l1xa7 34 13 to to TO cord-286132-ag2l1xa7 34 14 determine determine VB cord-286132-ag2l1xa7 34 15 the the DT cord-286132-ag2l1xa7 34 16 risk risk NN cord-286132-ag2l1xa7 34 17 of of IN cord-286132-ag2l1xa7 34 18 RTIs rti NNS cord-286132-ag2l1xa7 34 19 and and CC cord-286132-ag2l1xa7 34 20 non non JJ cord-286132-ag2l1xa7 34 21 - - JJ cord-286132-ag2l1xa7 34 22 infectious infectious JJ cord-286132-ag2l1xa7 34 23 12 12 CD cord-286132-ag2l1xa7 35 1 We -PRON- PRP cord-286132-ag2l1xa7 35 2 evaluated evaluate VBD cord-286132-ag2l1xa7 35 3 the the DT cord-286132-ag2l1xa7 35 4 presence presence NN cord-286132-ag2l1xa7 35 5 of of IN cord-286132-ag2l1xa7 35 6 heterogeneity heterogeneity NN cord-286132-ag2l1xa7 35 7 across across IN cord-286132-ag2l1xa7 35 8 trials trial NNS cord-286132-ag2l1xa7 35 9 by by IN cord-286132-ag2l1xa7 35 10 using use VBG cord-286132-ag2l1xa7 35 11 the the DT cord-286132-ag2l1xa7 35 12 I I NNP cord-286132-ag2l1xa7 35 13 2 2 CD cord-286132-ag2l1xa7 35 14 statistic statistic NN cord-286132-ag2l1xa7 35 15 . . . cord-286132-ag2l1xa7 36 1 An an DT cord-286132-ag2l1xa7 36 2 I i NN cord-286132-ag2l1xa7 36 3 2 2 CD cord-286132-ag2l1xa7 36 4 value value NN cord-286132-ag2l1xa7 36 5 of of IN cord-286132-ag2l1xa7 36 6 < < $ cord-286132-ag2l1xa7 36 7 25 25 CD cord-286132-ag2l1xa7 36 8 % % NN cord-286132-ag2l1xa7 36 9 1 1 CD cord-286132-ag2l1xa7 36 10 indicated indicate VBD cord-286132-ag2l1xa7 36 11 low low JJ cord-286132-ag2l1xa7 36 12 heterogeneity heterogeneity NN cord-286132-ag2l1xa7 36 13 , , , cord-286132-ag2l1xa7 36 14 25 25 CD cord-286132-ag2l1xa7 36 15 - - SYM cord-286132-ag2l1xa7 36 16 75 75 CD cord-286132-ag2l1xa7 36 17 % % NN cord-286132-ag2l1xa7 36 18 as as IN cord-286132-ag2l1xa7 36 19 moderate moderate JJ cord-286132-ag2l1xa7 36 20 heterogeneity heterogeneity NN cord-286132-ag2l1xa7 36 21 and and CC cord-286132-ag2l1xa7 36 22 > > XX cord-286132-ag2l1xa7 36 23 75 75 CD cord-286132-ag2l1xa7 36 24 % % NN cord-286132-ag2l1xa7 36 25 as as IN cord-286132-ag2l1xa7 36 26 considerable considerable JJ cord-286132-ag2l1xa7 36 27 heterogeneity heterogeneity NN cord-286132-ag2l1xa7 36 28 , , , cord-286132-ag2l1xa7 36 29 2 2 CD cord-286132-ag2l1xa7 36 30 respectively respectively RB cord-286132-ag2l1xa7 36 31 . . . cord-286132-ag2l1xa7 37 1 29 29 CD cord-286132-ag2l1xa7 37 2 Heterogeneity heterogeneity NN cord-286132-ag2l1xa7 37 3 was be VBD cord-286132-ag2l1xa7 37 4 evaluated evaluate VBN cord-286132-ag2l1xa7 37 5 by by IN cord-286132-ag2l1xa7 37 6 using use VBG cord-286132-ag2l1xa7 37 7 Cochran Cochran NNP cord-286132-ag2l1xa7 37 8 's 's POS cord-286132-ag2l1xa7 37 9 Q q NN cord-286132-ag2l1xa7 37 10 - - HYPH cord-286132-ag2l1xa7 37 11 statistics statistic NNS cord-286132-ag2l1xa7 37 12 with with IN cord-286132-ag2l1xa7 37 13 a a DT cord-286132-ag2l1xa7 37 14 significance significance NN cord-286132-ag2l1xa7 37 15 level level NN cord-286132-ag2l1xa7 37 16 of of IN cord-286132-ag2l1xa7 37 17 3 3 CD cord-286132-ag2l1xa7 37 18 P<0 P<0 NNP cord-286132-ag2l1xa7 37 19 . . . cord-286132-ag2l1xa7 38 1 10 10 CD cord-286132-ag2l1xa7 38 2 . . . cord-286132-ag2l1xa7 38 3 30 30 CD cord-286132-ag2l1xa7 39 1 Begg Begg NNP cord-286132-ag2l1xa7 39 2 's 's POS cord-286132-ag2l1xa7 39 3 and and CC cord-286132-ag2l1xa7 39 4 Egger Egger NNP cord-286132-ag2l1xa7 39 5 's 's POS cord-286132-ag2l1xa7 39 6 tests test NNS cord-286132-ag2l1xa7 39 7 were be VBD cord-286132-ag2l1xa7 39 8 performed perform VBN cord-286132-ag2l1xa7 39 9 to to TO cord-286132-ag2l1xa7 39 10 access access VB cord-286132-ag2l1xa7 39 11 publication publication NN cord-286132-ag2l1xa7 39 12 bias bias NN cord-286132-ag2l1xa7 39 13 and and CC cord-286132-ag2l1xa7 39 14 funnel funnel VB cord-286132-ag2l1xa7 39 15 plots plot NNS cord-286132-ag2l1xa7 39 16 were be VBD cord-286132-ag2l1xa7 39 17 4 4 CD cord-286132-ag2l1xa7 39 18 constructed construct VBN cord-286132-ag2l1xa7 39 19 to to TO cord-286132-ag2l1xa7 39 20 visualize visualize VB cord-286132-ag2l1xa7 39 21 possible possible JJ cord-286132-ag2l1xa7 39 22 asymmetry asymmetry NN cord-286132-ag2l1xa7 39 23 when when WRB cord-286132-ag2l1xa7 39 24 three three CD cord-286132-ag2l1xa7 39 25 or or CC cord-286132-ag2l1xa7 39 26 more more JJR cord-286132-ag2l1xa7 39 27 studies study NNS cord-286132-ag2l1xa7 39 28 were be VBD cord-286132-ag2l1xa7 39 29 available available JJ cord-286132-ag2l1xa7 39 30 . . . cord-286132-ag2l1xa7 40 1 31 31 CD cord-286132-ag2l1xa7 40 2 , , , cord-286132-ag2l1xa7 40 3 32 32 CD cord-286132-ag2l1xa7 40 4 5 5 CD cord-286132-ag2l1xa7 40 5 Statistical statistical JJ cord-286132-ag2l1xa7 40 6 analyses analysis NNS cord-286132-ag2l1xa7 40 7 were be VBD cord-286132-ag2l1xa7 40 8 performed perform VBN cord-286132-ag2l1xa7 40 9 using use VBG cord-286132-ag2l1xa7 40 10 the the DT cord-286132-ag2l1xa7 40 11 Comprehensive Comprehensive NNP cord-286132-ag2l1xa7 40 12 Meta Meta NNP cord-286132-ag2l1xa7 40 13 - - HYPH cord-286132-ag2l1xa7 40 14 Analysis Analysis NNP cord-286132-ag2l1xa7 40 15 Software Software NNP cord-286132-ag2l1xa7 40 16 ( ( -LRB- cord-286132-ag2l1xa7 40 17 version version NN cord-286132-ag2l1xa7 40 18 2.0 2.0 CD cord-286132-ag2l1xa7 40 19 ; ; : cord-286132-ag2l1xa7 40 20 6 6 CD cord-286132-ag2l1xa7 40 21 Biostat Biostat NNP cord-286132-ag2l1xa7 40 22 , , , cord-286132-ag2l1xa7 40 23 Englewood Englewood NNP cord-286132-ag2l1xa7 40 24 , , , cord-286132-ag2l1xa7 40 25 NJ NJ NNP cord-286132-ag2l1xa7 40 26 , , , cord-286132-ag2l1xa7 40 27 USA USA NNP cord-286132-ag2l1xa7 40 28 ) ) -RRB- cord-286132-ag2l1xa7 40 29 . . . cord-286132-ag2l1xa7 41 1 All all DT cord-286132-ag2l1xa7 41 2 statistical statistical JJ cord-286132-ag2l1xa7 41 3 tests test NNS cord-286132-ag2l1xa7 41 4 used use VBD cord-286132-ag2l1xa7 41 5 a a DT cord-286132-ag2l1xa7 41 6 two two CD cord-286132-ag2l1xa7 41 7 - - HYPH cord-286132-ag2l1xa7 41 8 sided sided JJ cord-286132-ag2l1xa7 41 9 a a DT cord-286132-ag2l1xa7 41 10 value value NN cord-286132-ag2l1xa7 41 11 of of IN cord-286132-ag2l1xa7 41 12 0.05 0.05 CD cord-286132-ag2l1xa7 41 13 for for IN cord-286132-ag2l1xa7 41 14 significance significance NN cord-286132-ag2l1xa7 41 15 . . . cord-286132-ag2l1xa7 42 1 characteristics characteristic NNS cord-286132-ag2l1xa7 42 2 and and CC cord-286132-ag2l1xa7 42 3 outcomes outcome NNS cord-286132-ag2l1xa7 42 4 of of IN cord-286132-ag2l1xa7 42 5 the the DT cord-286132-ag2l1xa7 42 6 included include VBN cord-286132-ag2l1xa7 42 7 studies study NNS cord-286132-ag2l1xa7 42 8 are be VBP cord-286132-ag2l1xa7 42 9 summarized summarize VBN cord-286132-ag2l1xa7 42 10 in in IN cord-286132-ag2l1xa7 42 11 Table Table NNP cord-286132-ag2l1xa7 42 12 1 1 CD cord-286132-ag2l1xa7 42 13 The the DT cord-286132-ag2l1xa7 42 14 percentage percentage NN cord-286132-ag2l1xa7 42 15 of of IN cord-286132-ag2l1xa7 42 16 studies study NNS cord-286132-ag2l1xa7 42 17 which which WDT cord-286132-ag2l1xa7 42 18 permitted permit VBD cord-286132-ag2l1xa7 42 19 to to TO cord-286132-ag2l1xa7 42 20 use use VB cord-286132-ag2l1xa7 42 21 concomitant concomitant JJ cord-286132-ag2l1xa7 42 22 drugs drug NNS cord-286132-ag2l1xa7 42 23 ( ( -LRB- cord-286132-ag2l1xa7 42 24 e.g. e.g. IN cord-286132-ag2l1xa7 42 25 corticosteroids corticosteroid NNS cord-286132-ag2l1xa7 42 26 , , , cord-286132-ag2l1xa7 42 27 budesonide budesonide NN cord-286132-ag2l1xa7 42 28 , , , cord-286132-ag2l1xa7 42 29 13 13 CD cord-286132-ag2l1xa7 42 30 thiopurines thiopurine NNS cord-286132-ag2l1xa7 42 31 , , , cord-286132-ag2l1xa7 42 32 methotrexate methotrexate NNP cord-286132-ag2l1xa7 42 33 , , , cord-286132-ag2l1xa7 42 34 calcineurin calcineurin NNP cord-286132-ag2l1xa7 42 35 inhibitors inhibitor NNS cord-286132-ag2l1xa7 42 36 , , , cord-286132-ag2l1xa7 42 37 or or CC cord-286132-ag2l1xa7 42 38 aminosalicylates aminosalicylates NNP cord-286132-ag2l1xa7 42 39 ) ) -RRB- cord-286132-ag2l1xa7 42 40 during during IN cord-286132-ag2l1xa7 42 41 the the DT cord-286132-ag2l1xa7 42 42 trials trial NNS cord-286132-ag2l1xa7 42 43 was be VBD cord-286132-ag2l1xa7 42 44 40.0 40.0 CD cord-286132-ag2l1xa7 42 45 % % NN cord-286132-ag2l1xa7 42 46 for for IN cord-286132-ag2l1xa7 42 47 14 14 CD cord-286132-ag2l1xa7 42 48 risankizumab risankizumab NNS cord-286132-ag2l1xa7 42 49 , , , cord-286132-ag2l1xa7 42 50 38.5 38.5 CD cord-286132-ag2l1xa7 42 51 % % NN cord-286132-ag2l1xa7 42 52 for for IN cord-286132-ag2l1xa7 42 53 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 42 54 , , , cord-286132-ag2l1xa7 42 55 37.5 37.5 CD cord-286132-ag2l1xa7 42 56 % % NN cord-286132-ag2l1xa7 42 57 for for IN cord-286132-ag2l1xa7 42 58 briakinumab briakinumab NN cord-286132-ag2l1xa7 42 59 , , , cord-286132-ag2l1xa7 42 60 0 0 CD cord-286132-ag2l1xa7 42 61 % % NN cord-286132-ag2l1xa7 42 62 for for IN cord-286132-ag2l1xa7 42 63 guselkumab guselkumab NNS cord-286132-ag2l1xa7 42 64 , , , cord-286132-ag2l1xa7 42 65 and and CC cord-286132-ag2l1xa7 42 66 0 0 CD cord-286132-ag2l1xa7 42 67 % % NN cord-286132-ag2l1xa7 42 68 for for IN cord-286132-ag2l1xa7 42 69 tildrakizumab tildrakizumab NNS cord-286132-ag2l1xa7 42 70 . . . cord-286132-ag2l1xa7 43 1 15 15 CD cord-286132-ag2l1xa7 44 1 As as IN cord-286132-ag2l1xa7 44 2 for for IN cord-286132-ag2l1xa7 44 3 brazikumab brazikumab NNP cord-286132-ag2l1xa7 44 4 , , , cord-286132-ag2l1xa7 44 5 one one CD cord-286132-ag2l1xa7 44 6 study study NN cord-286132-ag2l1xa7 44 7 for for IN cord-286132-ag2l1xa7 44 8 CD CD NNP cord-286132-ag2l1xa7 44 9 was be VBD cord-286132-ag2l1xa7 44 10 included include VBN cord-286132-ag2l1xa7 44 11 in in IN cord-286132-ag2l1xa7 44 12 this this DT cord-286132-ag2l1xa7 44 13 analysis analysis NN cord-286132-ag2l1xa7 44 14 and and CC cord-286132-ag2l1xa7 44 15 permitted permit VBD cord-286132-ag2l1xa7 44 16 concomitant concomitant JJ cord-286132-ag2l1xa7 44 17 drugs drug NNS cord-286132-ag2l1xa7 44 18 ( ( -LRB- cord-286132-ag2l1xa7 44 19 Table table NN cord-286132-ag2l1xa7 44 20 1 1 CD cord-286132-ag2l1xa7 44 21 ) ) -RRB- cord-286132-ag2l1xa7 44 22 . . . cord-286132-ag2l1xa7 45 1 16 16 CD cord-286132-ag2l1xa7 45 2 Meta Meta NNP cord-286132-ag2l1xa7 45 3 - - HYPH cord-286132-ag2l1xa7 45 4 analysis analysis NN cord-286132-ag2l1xa7 45 5 with with IN cord-286132-ag2l1xa7 45 6 a a DT cord-286132-ag2l1xa7 45 7 random random JJ cord-286132-ag2l1xa7 45 8 - - HYPH cord-286132-ag2l1xa7 45 9 effects effect NNS cord-286132-ag2l1xa7 45 10 model model NN cord-286132-ag2l1xa7 45 11 showed show VBD cord-286132-ag2l1xa7 45 12 that that IN cord-286132-ag2l1xa7 45 13 the the DT cord-286132-ag2l1xa7 45 14 overall overall JJ cord-286132-ag2l1xa7 45 15 risk risk NN cord-286132-ag2l1xa7 45 16 of of IN cord-286132-ag2l1xa7 45 17 RTIs rti NNS cord-286132-ag2l1xa7 45 18 with with IN cord-286132-ag2l1xa7 45 19 1 1 CD cord-286132-ag2l1xa7 45 20 anti anti JJ cord-286132-ag2l1xa7 45 21 - - JJ cord-286132-ag2l1xa7 45 22 IL-12 IL-12 NNP cord-286132-ag2l1xa7 45 23 / / SYM cord-286132-ag2l1xa7 45 24 IL-23 IL-23 NNP cord-286132-ag2l1xa7 45 25 or or CC cord-286132-ag2l1xa7 45 26 anti anti NNP cord-286132-ag2l1xa7 45 27 - - JJ cord-286132-ag2l1xa7 45 28 IL-23 IL-23 NNP cord-286132-ag2l1xa7 45 29 agents agent NNS cord-286132-ag2l1xa7 45 30 was be VBD cord-286132-ag2l1xa7 45 31 significantly significantly RB cord-286132-ag2l1xa7 45 32 higher high JJR cord-286132-ag2l1xa7 45 33 than than IN cord-286132-ag2l1xa7 45 34 that that DT cord-286132-ag2l1xa7 45 35 of of IN cord-286132-ag2l1xa7 45 36 placebo placebo NN cord-286132-ag2l1xa7 45 37 ( ( -LRB- cord-286132-ag2l1xa7 45 38 MH MH NNP cord-286132-ag2l1xa7 45 39 RD RD NNP cord-286132-ag2l1xa7 45 40 0.019 0.019 CD cord-286132-ag2l1xa7 45 41 , , , cord-286132-ag2l1xa7 45 42 95 95 CD cord-286132-ag2l1xa7 45 43 % % NN cord-286132-ag2l1xa7 45 44 2 2 CD cord-286132-ag2l1xa7 45 45 confidence confidence NN cord-286132-ag2l1xa7 45 46 interval interval NN cord-286132-ag2l1xa7 45 47 [ [ -LRB- cord-286132-ag2l1xa7 45 48 CI CI NNP cord-286132-ag2l1xa7 45 49 ] ] -RRB- cord-286132-ag2l1xa7 45 50 0.005 0.005 CD cord-286132-ag2l1xa7 45 51 - - HYPH cord-286132-ag2l1xa7 45 52 0.033 0.033 CD cord-286132-ag2l1xa7 45 53 , , , cord-286132-ag2l1xa7 45 54 P p NN cord-286132-ag2l1xa7 45 55 = = SYM cord-286132-ag2l1xa7 45 56 0.007 0.007 CD cord-286132-ag2l1xa7 45 57 ) ) -RRB- cord-286132-ag2l1xa7 46 1 ( ( -LRB- cord-286132-ag2l1xa7 46 2 Figure figure NN cord-286132-ag2l1xa7 46 3 2 2 CD cord-286132-ag2l1xa7 46 4 ) ) -RRB- cord-286132-ag2l1xa7 46 5 . . . cord-286132-ag2l1xa7 47 1 The the DT cord-286132-ag2l1xa7 47 2 number number NN cord-286132-ag2l1xa7 47 3 needed need VBN cord-286132-ag2l1xa7 47 4 to to TO cord-286132-ag2l1xa7 47 5 harm harm NN cord-286132-ag2l1xa7 47 6 of of IN cord-286132-ag2l1xa7 47 7 RTIs rti NNS cord-286132-ag2l1xa7 47 8 was be VBD cord-286132-ag2l1xa7 47 9 58.8 58.8 CD cord-286132-ag2l1xa7 47 10 . . . cord-286132-ag2l1xa7 48 1 3 3 LS cord-286132-ag2l1xa7 49 1 Subgroup Subgroup NNP cord-286132-ag2l1xa7 49 2 analysis analysis NN cord-286132-ag2l1xa7 49 3 revealed reveal VBD cord-286132-ag2l1xa7 49 4 a a DT cord-286132-ag2l1xa7 49 5 significantly significantly RB cord-286132-ag2l1xa7 49 6 increased increase VBN cord-286132-ag2l1xa7 49 7 risk risk NN cord-286132-ag2l1xa7 49 8 of of IN cord-286132-ag2l1xa7 49 9 RTIs rti NNS cord-286132-ag2l1xa7 49 10 with with IN cord-286132-ag2l1xa7 49 11 briakinumab briakinumab NNP cord-286132-ag2l1xa7 49 12 ( ( -LRB- cord-286132-ag2l1xa7 49 13 MH MH NNP cord-286132-ag2l1xa7 49 14 RD RD NNP cord-286132-ag2l1xa7 49 15 0.021 0.021 CD cord-286132-ag2l1xa7 49 16 , , , cord-286132-ag2l1xa7 49 17 95 95 CD cord-286132-ag2l1xa7 49 18 % % NN cord-286132-ag2l1xa7 49 19 CI CI NNP cord-286132-ag2l1xa7 49 20 4 4 CD cord-286132-ag2l1xa7 49 21 0.001 0.001 CD cord-286132-ag2l1xa7 49 22 - - HYPH cord-286132-ag2l1xa7 49 23 0.041 0.041 CD cord-286132-ag2l1xa7 49 24 , , , cord-286132-ag2l1xa7 49 25 P p NN cord-286132-ag2l1xa7 49 26 = = SYM cord-286132-ag2l1xa7 49 27 0.036 0.036 CD cord-286132-ag2l1xa7 49 28 ) ) -RRB- cord-286132-ag2l1xa7 49 29 and and CC cord-286132-ag2l1xa7 49 30 risankizumab risankizumab NNP cord-286132-ag2l1xa7 49 31 ( ( -LRB- cord-286132-ag2l1xa7 49 32 MH MH NNP cord-286132-ag2l1xa7 49 33 RD RD NNP cord-286132-ag2l1xa7 49 34 0.040 0.040 CD cord-286132-ag2l1xa7 49 35 , , , cord-286132-ag2l1xa7 49 36 95 95 CD cord-286132-ag2l1xa7 49 37 % % NN cord-286132-ag2l1xa7 49 38 CI CI NNP cord-286132-ag2l1xa7 49 39 0.005 0.005 CD cord-286132-ag2l1xa7 49 40 - - HYPH cord-286132-ag2l1xa7 49 41 0.076 0.076 CD cord-286132-ag2l1xa7 49 42 , , , cord-286132-ag2l1xa7 49 43 P p NN cord-286132-ag2l1xa7 49 44 = = SYM cord-286132-ag2l1xa7 49 45 0.026 0.026 CD cord-286132-ag2l1xa7 49 46 ) ) -RRB- cord-286132-ag2l1xa7 49 47 . . . cord-286132-ag2l1xa7 50 1 Heterogeneity heterogeneity NN cord-286132-ag2l1xa7 50 2 5 5 CD cord-286132-ag2l1xa7 50 3 was be VBD cord-286132-ag2l1xa7 50 4 absent absent JJ cord-286132-ag2l1xa7 51 1 ( ( -LRB- cord-286132-ag2l1xa7 51 2 I i NN cord-286132-ag2l1xa7 51 3 2 2 CD cord-286132-ag2l1xa7 51 4 = = SYM cord-286132-ag2l1xa7 51 5 0 0 CD cord-286132-ag2l1xa7 51 6 % % NN cord-286132-ag2l1xa7 51 7 ) ) -RRB- cord-286132-ag2l1xa7 51 8 in in IN cord-286132-ag2l1xa7 51 9 overall overall JJ cord-286132-ag2l1xa7 51 10 and and CC cord-286132-ag2l1xa7 51 11 subgroup subgroup NN cord-286132-ag2l1xa7 51 12 analyses analysis NNS cord-286132-ag2l1xa7 51 13 except except IN cord-286132-ag2l1xa7 51 14 for for IN cord-286132-ag2l1xa7 51 15 briakinumab briakinumab NN cord-286132-ag2l1xa7 51 16 ( ( -LRB- cord-286132-ag2l1xa7 51 17 I i NN cord-286132-ag2l1xa7 51 18 2 2 CD cord-286132-ag2l1xa7 51 19 = = SYM cord-286132-ag2l1xa7 51 20 31 31 CD cord-286132-ag2l1xa7 51 21 % % NN cord-286132-ag2l1xa7 51 22 ) ) -RRB- cord-286132-ag2l1xa7 51 23 . . . cord-286132-ag2l1xa7 52 1 Funnel funnel VB cord-286132-ag2l1xa7 52 2 plot plot NN cord-286132-ag2l1xa7 52 3 6 6 CD cord-286132-ag2l1xa7 52 4 demonstrated demonstrate VBD cord-286132-ag2l1xa7 52 5 no no DT cord-286132-ag2l1xa7 52 6 asymmetry asymmetry NN cord-286132-ag2l1xa7 52 7 , , , cord-286132-ag2l1xa7 52 8 therefore therefore RB cord-286132-ag2l1xa7 52 9 suggesting suggest VBG cord-286132-ag2l1xa7 52 10 there there EX cord-286132-ag2l1xa7 52 11 was be VBD cord-286132-ag2l1xa7 52 12 no no DT cord-286132-ag2l1xa7 52 13 small small JJ cord-286132-ag2l1xa7 52 14 - - HYPH cord-286132-ag2l1xa7 52 15 study study NN cord-286132-ag2l1xa7 52 16 effects effect NNS cord-286132-ag2l1xa7 52 17 or or CC cord-286132-ag2l1xa7 52 18 publication publication NN cord-286132-ag2l1xa7 52 19 bias bias NN cord-286132-ag2l1xa7 52 20 , , , cord-286132-ag2l1xa7 52 21 which which WDT cord-286132-ag2l1xa7 52 22 7 7 CD cord-286132-ag2l1xa7 52 23 was be VBD cord-286132-ag2l1xa7 52 24 supported support VBN cord-286132-ag2l1xa7 52 25 by by IN cord-286132-ag2l1xa7 52 26 Begg Begg NNP cord-286132-ag2l1xa7 52 27 's 's POS cord-286132-ag2l1xa7 52 28 and and CC cord-286132-ag2l1xa7 52 29 Egger Egger NNP cord-286132-ag2l1xa7 52 30 's 's POS cord-286132-ag2l1xa7 52 31 tests test NNS cord-286132-ag2l1xa7 52 32 ( ( -LRB- cord-286132-ag2l1xa7 52 33 Figure Figure NNP cord-286132-ag2l1xa7 52 34 S1 S1 NNP cord-286132-ag2l1xa7 52 35 ) ) -RRB- cord-286132-ag2l1xa7 52 36 . . . cord-286132-ag2l1xa7 53 1 We -PRON- PRP cord-286132-ag2l1xa7 53 2 also also RB cord-286132-ag2l1xa7 53 3 assessed assess VBD cord-286132-ag2l1xa7 53 4 the the DT cord-286132-ag2l1xa7 53 5 differential differential JJ cord-286132-ag2l1xa7 53 6 risk risk NN cord-286132-ag2l1xa7 53 7 of of IN cord-286132-ag2l1xa7 53 8 RTIs rti NNS cord-286132-ag2l1xa7 53 9 by by IN cord-286132-ag2l1xa7 53 10 8 8 CD cord-286132-ag2l1xa7 53 11 underlying underlie VBG cord-286132-ag2l1xa7 53 12 disease disease NN cord-286132-ag2l1xa7 53 13 and and CC cord-286132-ag2l1xa7 53 14 showed show VBD cord-286132-ag2l1xa7 53 15 a a DT cord-286132-ag2l1xa7 53 16 significantly significantly RB cord-286132-ag2l1xa7 53 17 increased increase VBN cord-286132-ag2l1xa7 53 18 risk risk NN cord-286132-ag2l1xa7 53 19 of of IN cord-286132-ag2l1xa7 53 20 RTIs rti NNS cord-286132-ag2l1xa7 53 21 in in IN cord-286132-ag2l1xa7 53 22 psoriasis psoriasis NN cord-286132-ag2l1xa7 53 23 ( ( -LRB- cord-286132-ag2l1xa7 53 24 MH MH NNP cord-286132-ag2l1xa7 53 25 RD RD NNP cord-286132-ag2l1xa7 53 26 0.023 0.023 CD cord-286132-ag2l1xa7 53 27 , , , cord-286132-ag2l1xa7 53 28 95 95 CD cord-286132-ag2l1xa7 53 29 % % NN cord-286132-ag2l1xa7 54 1 CI CI NNP cord-286132-ag2l1xa7 54 2 We -PRON- PRP cord-286132-ag2l1xa7 54 3 divided divide VBD cord-286132-ag2l1xa7 54 4 RTIs rti NNS cord-286132-ag2l1xa7 54 5 into into IN cord-286132-ag2l1xa7 54 6 URTIs urti NNS cord-286132-ag2l1xa7 54 7 , , , cord-286132-ag2l1xa7 54 8 viral viral JJ cord-286132-ag2l1xa7 54 9 URTIs urti NNS cord-286132-ag2l1xa7 54 10 , , , cord-286132-ag2l1xa7 54 11 and and CC cord-286132-ag2l1xa7 54 12 LRTIs lrti NNS cord-286132-ag2l1xa7 54 13 and and CC cord-286132-ag2l1xa7 54 14 investigated investigate VBD cord-286132-ag2l1xa7 54 15 each each DT cord-286132-ag2l1xa7 54 16 risk risk NN cord-286132-ag2l1xa7 54 17 with with IN cord-286132-ag2l1xa7 54 18 IL-12/23 il-12/23 NN cord-286132-ag2l1xa7 54 19 or or CC cord-286132-ag2l1xa7 54 20 12 12 CD cord-286132-ag2l1xa7 54 21 IL-23 IL-23 NNP cord-286132-ag2l1xa7 54 22 inhibitors inhibitor NNS cord-286132-ag2l1xa7 54 23 . . . cord-286132-ag2l1xa7 55 1 The the DT cord-286132-ag2l1xa7 55 2 overall overall JJ cord-286132-ag2l1xa7 55 3 risk risk NN cord-286132-ag2l1xa7 55 4 of of IN cord-286132-ag2l1xa7 55 5 URTIs urti NNS cord-286132-ag2l1xa7 55 6 was be VBD cord-286132-ag2l1xa7 55 7 significantly significantly RB cord-286132-ag2l1xa7 55 8 higher high JJR cord-286132-ag2l1xa7 55 9 in in IN cord-286132-ag2l1xa7 55 10 the the DT cord-286132-ag2l1xa7 55 11 treatment treatment NN cord-286132-ag2l1xa7 55 12 group group NN cord-286132-ag2l1xa7 55 13 compared compare VBN cord-286132-ag2l1xa7 55 14 to to IN cord-286132-ag2l1xa7 55 15 Anti Anti NNP cord-286132-ag2l1xa7 55 16 - - JJ cord-286132-ag2l1xa7 55 17 IL-12 IL-12 NNP cord-286132-ag2l1xa7 55 18 / / SYM cord-286132-ag2l1xa7 55 19 IL-23 IL-23 NNP cord-286132-ag2l1xa7 55 20 or or CC cord-286132-ag2l1xa7 55 21 anti anti NNP cord-286132-ag2l1xa7 55 22 - - JJ cord-286132-ag2l1xa7 55 23 IL-23 IL-23 NNP cord-286132-ag2l1xa7 55 24 agents agent NNS cord-286132-ag2l1xa7 55 25 did do VBD cord-286132-ag2l1xa7 55 26 not not RB cord-286132-ag2l1xa7 55 27 increase increase VB cord-286132-ag2l1xa7 55 28 the the DT cord-286132-ag2l1xa7 55 29 overall overall JJ cord-286132-ag2l1xa7 55 30 risks risk NNS cord-286132-ag2l1xa7 55 31 of of IN cord-286132-ag2l1xa7 55 32 viral viral JJ cord-286132-ag2l1xa7 55 33 URTIs urti NNS cord-286132-ag2l1xa7 55 34 ( ( -LRB- cord-286132-ag2l1xa7 55 35 MH MH NNP cord-286132-ag2l1xa7 55 36 RD RD NNP cord-286132-ag2l1xa7 55 37 17 17 CD cord-286132-ag2l1xa7 55 38 0.001 0.001 CD cord-286132-ag2l1xa7 55 39 , , , cord-286132-ag2l1xa7 55 40 95 95 CD cord-286132-ag2l1xa7 55 41 % % NN cord-286132-ag2l1xa7 56 1 CI CI NNP cord-286132-ag2l1xa7 56 2 -0.002 -0.002 NNP cord-286132-ag2l1xa7 56 3 - - HYPH cord-286132-ag2l1xa7 56 4 0.003 0.003 CD cord-286132-ag2l1xa7 56 5 , , , cord-286132-ag2l1xa7 56 6 P p NN cord-286132-ag2l1xa7 56 7 = = SYM cord-286132-ag2l1xa7 56 8 0.60 0.60 CD cord-286132-ag2l1xa7 56 9 ) ) -RRB- cord-286132-ag2l1xa7 56 10 and and CC cord-286132-ag2l1xa7 56 11 LRTIs LRTIs NNP cord-286132-ag2l1xa7 56 12 ( ( -LRB- cord-286132-ag2l1xa7 56 13 MH MH NNP cord-286132-ag2l1xa7 56 14 RD RD NNP cord-286132-ag2l1xa7 56 15 0 0 CD cord-286132-ag2l1xa7 56 16 , , , cord-286132-ag2l1xa7 56 17 95 95 CD cord-286132-ag2l1xa7 56 18 % % NN cord-286132-ag2l1xa7 57 1 CI CI NNP cord-286132-ag2l1xa7 57 2 -0.002 -0.002 NNP cord-286132-ag2l1xa7 57 3 - - HYPH cord-286132-ag2l1xa7 57 4 0.002 0.002 NNP cord-286132-ag2l1xa7 57 5 , , , cord-286132-ag2l1xa7 57 6 P p NN cord-286132-ag2l1xa7 57 7 = = SYM cord-286132-ag2l1xa7 57 8 0.71 0.71 CD cord-286132-ag2l1xa7 57 9 ) ) -RRB- cord-286132-ag2l1xa7 58 1 ( ( -LRB- cord-286132-ag2l1xa7 58 2 Figure figure NN cord-286132-ag2l1xa7 58 3 S4A s4a NN cord-286132-ag2l1xa7 58 4 , , , cord-286132-ag2l1xa7 58 5 18 18 CD cord-286132-ag2l1xa7 58 6 S5A s5a CD cord-286132-ag2l1xa7 58 7 ) ) -RRB- cord-286132-ag2l1xa7 58 8 . . . cord-286132-ag2l1xa7 59 1 Heterogeneity heterogeneity NN cord-286132-ag2l1xa7 59 2 was be VBD cord-286132-ag2l1xa7 59 3 absent absent JJ cord-286132-ag2l1xa7 60 1 ( ( -LRB- cord-286132-ag2l1xa7 60 2 I i NN cord-286132-ag2l1xa7 60 3 2 2 CD cord-286132-ag2l1xa7 60 4 = = SYM cord-286132-ag2l1xa7 60 5 0 0 CD cord-286132-ag2l1xa7 60 6 % % NN cord-286132-ag2l1xa7 60 7 ) ) -RRB- cord-286132-ag2l1xa7 60 8 in in IN cord-286132-ag2l1xa7 60 9 these these DT cord-286132-ag2l1xa7 60 10 analyses analysis NNS cord-286132-ag2l1xa7 60 11 . . . cord-286132-ag2l1xa7 61 1 Publication publication NN cord-286132-ag2l1xa7 61 2 bias bias NN cord-286132-ag2l1xa7 61 3 was be VBD cord-286132-ag2l1xa7 61 4 indicated indicate VBN cord-286132-ag2l1xa7 61 5 in in IN cord-286132-ag2l1xa7 61 6 the the DT cord-286132-ag2l1xa7 61 7 analysis analysis NN cord-286132-ag2l1xa7 61 8 of of IN cord-286132-ag2l1xa7 61 9 19 19 CD cord-286132-ag2l1xa7 61 10 viral viral JJ cord-286132-ag2l1xa7 61 11 URTIs urti NNS cord-286132-ag2l1xa7 61 12 ( ( -LRB- cord-286132-ag2l1xa7 61 13 Begg Begg NNP cord-286132-ag2l1xa7 61 14 : : : cord-286132-ag2l1xa7 61 15 P p NN cord-286132-ag2l1xa7 61 16 < < XX cord-286132-ag2l1xa7 61 17 0.001 0.001 CD cord-286132-ag2l1xa7 61 18 , , , cord-286132-ag2l1xa7 61 19 Egger Egger NNP cord-286132-ag2l1xa7 61 20 : : : cord-286132-ag2l1xa7 61 21 P p NN cord-286132-ag2l1xa7 61 22 = = SYM cord-286132-ag2l1xa7 61 23 0.019 0.019 CD cord-286132-ag2l1xa7 61 24 ) ) -RRB- cord-286132-ag2l1xa7 62 1 ( ( -LRB- cord-286132-ag2l1xa7 62 2 Figure figure NN cord-286132-ag2l1xa7 62 3 S4B s4b CD cord-286132-ag2l1xa7 62 4 ) ) -RRB- cord-286132-ag2l1xa7 62 5 and and CC cord-286132-ag2l1xa7 62 6 LRTIs lrtis ADD cord-286132-ag2l1xa7 63 1 ( ( -LRB- cord-286132-ag2l1xa7 63 2 Begg Begg NNP cord-286132-ag2l1xa7 63 3 : : : cord-286132-ag2l1xa7 63 4 P p NN cord-286132-ag2l1xa7 63 5 < < XX cord-286132-ag2l1xa7 63 6 0.001 0.001 CD cord-286132-ag2l1xa7 63 7 , , , cord-286132-ag2l1xa7 63 8 Egger Egger NNP cord-286132-ag2l1xa7 63 9 : : : cord-286132-ag2l1xa7 63 10 P p NN cord-286132-ag2l1xa7 63 11 = = SYM cord-286132-ag2l1xa7 63 12 0.55 0.55 CD cord-286132-ag2l1xa7 63 13 ) ) -RRB- cord-286132-ag2l1xa7 63 14 1 1 CD cord-286132-ag2l1xa7 64 1 ( ( -LRB- cord-286132-ag2l1xa7 64 2 Figure figure NN cord-286132-ag2l1xa7 64 3 S5B S5B NNP cord-286132-ag2l1xa7 64 4 ) ) -RRB- cord-286132-ag2l1xa7 64 5 , , . cord-286132-ag2l1xa7 65 1 but but CC cord-286132-ag2l1xa7 65 2 the the DT cord-286132-ag2l1xa7 65 3 funnel funnel NN cord-286132-ag2l1xa7 65 4 plots plot NNS cord-286132-ag2l1xa7 65 5 did do VBD cord-286132-ag2l1xa7 65 6 not not RB cord-286132-ag2l1xa7 65 7 appear appear VB cord-286132-ag2l1xa7 65 8 asymmetric asymmetric JJ cord-286132-ag2l1xa7 65 9 on on IN cord-286132-ag2l1xa7 65 10 visual visual JJ cord-286132-ag2l1xa7 65 11 inspection inspection NN cord-286132-ag2l1xa7 65 12 . . . cord-286132-ag2l1xa7 66 1 2 2 LS cord-286132-ag2l1xa7 66 2 3 3 CD cord-286132-ag2l1xa7 66 3 The the DT cord-286132-ag2l1xa7 66 4 total total JJ cord-286132-ag2l1xa7 66 5 numbers number NNS cord-286132-ag2l1xa7 66 6 of of IN cord-286132-ag2l1xa7 66 7 infectious infectious JJ cord-286132-ag2l1xa7 66 8 pneumonia pneumonia NN cord-286132-ag2l1xa7 66 9 were be VBD cord-286132-ag2l1xa7 66 10 9 9 CD cord-286132-ag2l1xa7 66 11 and and CC cord-286132-ag2l1xa7 66 12 4 4 CD cord-286132-ag2l1xa7 66 13 cases case NNS cord-286132-ag2l1xa7 66 14 in in IN cord-286132-ag2l1xa7 66 15 the the DT cord-286132-ag2l1xa7 66 16 treatment treatment NN cord-286132-ag2l1xa7 66 17 group group NN cord-286132-ag2l1xa7 66 18 and and CC cord-286132-ag2l1xa7 66 19 placebo placebo NN cord-286132-ag2l1xa7 66 20 , , , cord-286132-ag2l1xa7 66 21 5 5 CD cord-286132-ag2l1xa7 66 22 respectively respectively RB cord-286132-ag2l1xa7 66 23 . . . cord-286132-ag2l1xa7 67 1 Mycobacterium Mycobacterium NNP cord-286132-ag2l1xa7 67 2 tuberculosis tuberculosis NN cord-286132-ag2l1xa7 67 3 and and CC cord-286132-ag2l1xa7 67 4 viral viral JJ cord-286132-ag2l1xa7 67 5 pneumonia pneumonia NN cord-286132-ag2l1xa7 67 6 were be VBD cord-286132-ag2l1xa7 67 7 not not RB cord-286132-ag2l1xa7 67 8 reported report VBN cord-286132-ag2l1xa7 67 9 . . . cord-286132-ag2l1xa7 68 1 The the DT cord-286132-ag2l1xa7 68 2 overall overall JJ cord-286132-ag2l1xa7 68 3 risk risk NN cord-286132-ag2l1xa7 68 4 of of IN cord-286132-ag2l1xa7 68 5 6 6 CD cord-286132-ag2l1xa7 68 6 infectious infectious JJ cord-286132-ag2l1xa7 68 7 pneumonia pneumonia NN cord-286132-ag2l1xa7 68 8 was be VBD cord-286132-ag2l1xa7 68 9 not not RB cord-286132-ag2l1xa7 68 10 significantly significantly RB cord-286132-ag2l1xa7 68 11 increased increase VBN cord-286132-ag2l1xa7 68 12 in in IN cord-286132-ag2l1xa7 68 13 the the DT cord-286132-ag2l1xa7 68 14 treatment treatment NN cord-286132-ag2l1xa7 68 15 group group NN cord-286132-ag2l1xa7 68 16 compared compare VBN cord-286132-ag2l1xa7 68 17 to to IN cord-286132-ag2l1xa7 68 18 placebo placebo NN cord-286132-ag2l1xa7 68 19 ( ( -LRB- cord-286132-ag2l1xa7 68 20 MH MH NNP cord-286132-ag2l1xa7 68 21 RD RD NNP cord-286132-ag2l1xa7 68 22 0 0 CD cord-286132-ag2l1xa7 68 23 , , , cord-286132-ag2l1xa7 68 24 7 7 CD cord-286132-ag2l1xa7 68 25 95 95 CD cord-286132-ag2l1xa7 68 26 % % NN cord-286132-ag2l1xa7 68 27 CI CI NNP cord-286132-ag2l1xa7 68 28 -0.002 -0.002 NNP cord-286132-ag2l1xa7 68 29 - - HYPH cord-286132-ag2l1xa7 68 30 0.002 0.002 NNP cord-286132-ag2l1xa7 68 31 , , , cord-286132-ag2l1xa7 68 32 P p NN cord-286132-ag2l1xa7 68 33 = = SYM cord-286132-ag2l1xa7 68 34 0.87 0.87 CD cord-286132-ag2l1xa7 68 35 ) ) -RRB- cord-286132-ag2l1xa7 69 1 ( ( -LRB- cord-286132-ag2l1xa7 69 2 Figure figure NN cord-286132-ag2l1xa7 69 3 3 3 CD cord-286132-ag2l1xa7 69 4 ) ) -RRB- cord-286132-ag2l1xa7 69 5 . . . cord-286132-ag2l1xa7 70 1 Heterogeneity heterogeneity NN cord-286132-ag2l1xa7 70 2 was be VBD cord-286132-ag2l1xa7 70 3 absent absent JJ cord-286132-ag2l1xa7 71 1 ( ( -LRB- cord-286132-ag2l1xa7 71 2 I i NN cord-286132-ag2l1xa7 71 3 2 2 CD cord-286132-ag2l1xa7 71 4 = = SYM cord-286132-ag2l1xa7 71 5 0 0 CD cord-286132-ag2l1xa7 71 6 % % NN cord-286132-ag2l1xa7 71 7 ) ) -RRB- cord-286132-ag2l1xa7 71 8 . . . cord-286132-ag2l1xa7 72 1 The the DT cord-286132-ag2l1xa7 72 2 funnel funnel NN cord-286132-ag2l1xa7 72 3 plot plot NN cord-286132-ag2l1xa7 72 4 was be VBD cord-286132-ag2l1xa7 72 5 not not RB cord-286132-ag2l1xa7 72 6 8 8 CD cord-286132-ag2l1xa7 72 7 asymmetric asymmetric JJ cord-286132-ag2l1xa7 72 8 , , , cord-286132-ag2l1xa7 72 9 indicating indicate VBG cord-286132-ag2l1xa7 72 10 no no DT cord-286132-ag2l1xa7 72 11 publication publication NN cord-286132-ag2l1xa7 72 12 bias bias NN cord-286132-ag2l1xa7 72 13 , , , cord-286132-ag2l1xa7 72 14 which which WDT cord-286132-ag2l1xa7 72 15 was be VBD cord-286132-ag2l1xa7 72 16 supported support VBN cord-286132-ag2l1xa7 72 17 by by IN cord-286132-ag2l1xa7 72 18 Egger Egger NNP cord-286132-ag2l1xa7 72 19 's 's POS cord-286132-ag2l1xa7 72 20 test test NN cord-286132-ag2l1xa7 72 21 ( ( -LRB- cord-286132-ag2l1xa7 72 22 P p NN cord-286132-ag2l1xa7 72 23 = = SYM cord-286132-ag2l1xa7 72 24 0.93 0.93 CD cord-286132-ag2l1xa7 72 25 ) ) -RRB- cord-286132-ag2l1xa7 72 26 but but CC cord-286132-ag2l1xa7 72 27 not not RB cord-286132-ag2l1xa7 72 28 Begg Begg NNP cord-286132-ag2l1xa7 72 29 's 's POS cord-286132-ag2l1xa7 72 30 test test NN cord-286132-ag2l1xa7 72 31 9 9 CD cord-286132-ag2l1xa7 72 32 ( ( -LRB- cord-286132-ag2l1xa7 72 33 P p NN cord-286132-ag2l1xa7 72 34 < < XX cord-286132-ag2l1xa7 72 35 0.001 0.001 CD cord-286132-ag2l1xa7 72 36 ) ) -RRB- cord-286132-ag2l1xa7 72 37 ( ( -LRB- cord-286132-ag2l1xa7 72 38 Figure figure NN cord-286132-ag2l1xa7 72 39 S6 S6 NNP cord-286132-ag2l1xa7 72 40 ) ) -RRB- cord-286132-ag2l1xa7 72 41 . . . cord-286132-ag2l1xa7 73 1 10 10 CD cord-286132-ag2l1xa7 74 1 In in IN cord-286132-ag2l1xa7 74 2 terms term NNS cord-286132-ag2l1xa7 74 3 of of IN cord-286132-ag2l1xa7 74 4 non non JJ cord-286132-ag2l1xa7 74 5 - - JJ cord-286132-ag2l1xa7 74 6 infectious infectious JJ cord-286132-ag2l1xa7 74 7 ILD ILD NNP cord-286132-ag2l1xa7 74 8 , , , cord-286132-ag2l1xa7 74 9 2 2 CD cord-286132-ag2l1xa7 74 10 and and CC cord-286132-ag2l1xa7 74 11 1 1 CD cord-286132-ag2l1xa7 74 12 cases case NNS cord-286132-ag2l1xa7 74 13 were be VBD cord-286132-ag2l1xa7 74 14 identified identify VBN cord-286132-ag2l1xa7 74 15 in in IN cord-286132-ag2l1xa7 74 16 the the DT cord-286132-ag2l1xa7 74 17 treatment treatment NN cord-286132-ag2l1xa7 74 18 group group NN cord-286132-ag2l1xa7 74 19 and and CC cord-286132-ag2l1xa7 74 20 placebo placebo NN cord-286132-ag2l1xa7 74 21 , , , cord-286132-ag2l1xa7 74 22 11 11 CD cord-286132-ag2l1xa7 74 23 respectively respectively RB cord-286132-ag2l1xa7 74 24 . . . cord-286132-ag2l1xa7 75 1 All all DT cord-286132-ag2l1xa7 75 2 3 3 CD cord-286132-ag2l1xa7 75 3 cases case NNS cord-286132-ag2l1xa7 75 4 were be VBD cord-286132-ag2l1xa7 75 5 reported report VBN cord-286132-ag2l1xa7 75 6 in in IN cord-286132-ag2l1xa7 75 7 the the DT cord-286132-ag2l1xa7 75 8 trials trial NNS cord-286132-ag2l1xa7 75 9 of of IN cord-286132-ag2l1xa7 75 10 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 75 11 and and CC cord-286132-ag2l1xa7 75 12 occurred occur VBD cord-286132-ag2l1xa7 75 13 within within IN cord-286132-ag2l1xa7 75 14 16 16 CD cord-286132-ag2l1xa7 75 15 weeks week NNS cord-286132-ag2l1xa7 75 16 after after IN cord-286132-ag2l1xa7 75 17 12 12 CD cord-286132-ag2l1xa7 75 18 initiation initiation NN cord-286132-ag2l1xa7 75 19 of of IN cord-286132-ag2l1xa7 75 20 the the DT cord-286132-ag2l1xa7 75 21 trial trial NN cord-286132-ag2l1xa7 75 22 . . . cord-286132-ag2l1xa7 76 1 [ [ -LRB- cord-286132-ag2l1xa7 76 2 33 33 CD cord-286132-ag2l1xa7 76 3 ] ] -RRB- cord-286132-ag2l1xa7 76 4 [ [ -LRB- cord-286132-ag2l1xa7 76 5 34 34 CD cord-286132-ag2l1xa7 76 6 ] ] -RRB- cord-286132-ag2l1xa7 76 7 [ [ -LRB- cord-286132-ag2l1xa7 76 8 35 35 CD cord-286132-ag2l1xa7 76 9 ] ] -RRB- cord-286132-ag2l1xa7 77 1 The the DT cord-286132-ag2l1xa7 77 2 overall overall JJ cord-286132-ag2l1xa7 77 3 risk risk NN cord-286132-ag2l1xa7 77 4 of of IN cord-286132-ag2l1xa7 77 5 ILD ILD NNP cord-286132-ag2l1xa7 77 6 was be VBD cord-286132-ag2l1xa7 77 7 not not RB cord-286132-ag2l1xa7 77 8 significantly significantly RB cord-286132-ag2l1xa7 77 9 increased increase VBN cord-286132-ag2l1xa7 77 10 in in IN cord-286132-ag2l1xa7 77 11 the the DT cord-286132-ag2l1xa7 77 12 treatment treatment NN cord-286132-ag2l1xa7 77 13 group group NN cord-286132-ag2l1xa7 77 14 ( ( -LRB- cord-286132-ag2l1xa7 77 15 MH MH NNP cord-286132-ag2l1xa7 77 16 13 13 CD cord-286132-ag2l1xa7 77 17 RD RD NNP cord-286132-ag2l1xa7 77 18 0 0 CD cord-286132-ag2l1xa7 77 19 , , , cord-286132-ag2l1xa7 77 20 95 95 CD cord-286132-ag2l1xa7 77 21 % % NN cord-286132-ag2l1xa7 78 1 CI CI NNP cord-286132-ag2l1xa7 78 2 -0.002 -0.002 NNP cord-286132-ag2l1xa7 78 3 - - HYPH cord-286132-ag2l1xa7 78 4 0.002 0.002 NNP cord-286132-ag2l1xa7 78 5 , , , cord-286132-ag2l1xa7 78 6 P p NN cord-286132-ag2l1xa7 78 7 = = SYM cord-286132-ag2l1xa7 78 8 0.99 0.99 CD cord-286132-ag2l1xa7 78 9 ) ) -RRB- cord-286132-ag2l1xa7 79 1 ( ( -LRB- cord-286132-ag2l1xa7 79 2 Figure figure NN cord-286132-ag2l1xa7 79 3 4 4 CD cord-286132-ag2l1xa7 79 4 ) ) -RRB- cord-286132-ag2l1xa7 79 5 . . . cord-286132-ag2l1xa7 80 1 Heterogeneity heterogeneity NN cord-286132-ag2l1xa7 80 2 was be VBD cord-286132-ag2l1xa7 80 3 absent absent JJ cord-286132-ag2l1xa7 81 1 ( ( -LRB- cord-286132-ag2l1xa7 81 2 I i NN cord-286132-ag2l1xa7 81 3 2 2 CD cord-286132-ag2l1xa7 81 4 = = SYM cord-286132-ag2l1xa7 81 5 0 0 CD cord-286132-ag2l1xa7 81 6 % % NN cord-286132-ag2l1xa7 81 7 ) ) -RRB- cord-286132-ag2l1xa7 81 8 . . . cord-286132-ag2l1xa7 82 1 Begg Begg NNP cord-286132-ag2l1xa7 82 2 's 's POS cord-286132-ag2l1xa7 82 3 ( ( -LRB- cord-286132-ag2l1xa7 82 4 P p NN cord-286132-ag2l1xa7 82 5 < < XX cord-286132-ag2l1xa7 82 6 0.001 0.001 CD cord-286132-ag2l1xa7 82 7 ) ) -RRB- cord-286132-ag2l1xa7 82 8 , , , cord-286132-ag2l1xa7 82 9 but but CC cord-286132-ag2l1xa7 82 10 14 14 CD cord-286132-ag2l1xa7 82 11 not not RB cord-286132-ag2l1xa7 82 12 Egger Egger NNP cord-286132-ag2l1xa7 82 13 's 's POS cord-286132-ag2l1xa7 82 14 ( ( -LRB- cord-286132-ag2l1xa7 82 15 P p NN cord-286132-ag2l1xa7 82 16 = = SYM cord-286132-ag2l1xa7 82 17 0.69 0.69 CD cord-286132-ag2l1xa7 82 18 ) ) -RRB- cord-286132-ag2l1xa7 82 19 , , , cord-286132-ag2l1xa7 82 20 test test NN cord-286132-ag2l1xa7 82 21 was be VBD cord-286132-ag2l1xa7 82 22 suggestive suggestive JJ cord-286132-ag2l1xa7 82 23 of of IN cord-286132-ag2l1xa7 82 24 publication publication NN cord-286132-ag2l1xa7 82 25 bias bias NN cord-286132-ag2l1xa7 82 26 , , , cord-286132-ag2l1xa7 82 27 but but CC cord-286132-ag2l1xa7 82 28 the the DT cord-286132-ag2l1xa7 82 29 funnel funnel NN cord-286132-ag2l1xa7 82 30 plot plot NN cord-286132-ag2l1xa7 82 31 was be VBD cord-286132-ag2l1xa7 82 32 not not RB cord-286132-ag2l1xa7 82 33 asymmetric asymmetric JJ cord-286132-ag2l1xa7 83 1 ( ( -LRB- cord-286132-ag2l1xa7 83 2 The the DT cord-286132-ag2l1xa7 83 3 sensitivity sensitivity NN cord-286132-ag2l1xa7 83 4 analysis analysis NN cord-286132-ag2l1xa7 83 5 revealed reveal VBD cord-286132-ag2l1xa7 83 6 consistent consistent JJ cord-286132-ag2l1xa7 83 7 results result NNS cord-286132-ag2l1xa7 83 8 ( ( -LRB- cord-286132-ag2l1xa7 83 9 Table Table NNP cord-286132-ag2l1xa7 83 10 S1 S1 NNP cord-286132-ag2l1xa7 83 11 - - HYPH cord-286132-ag2l1xa7 83 12 2 2 CD cord-286132-ag2l1xa7 83 13 , , , cord-286132-ag2l1xa7 83 14 S4 S4 NNP cord-286132-ag2l1xa7 83 15 - - HYPH cord-286132-ag2l1xa7 83 16 5 5 CD cord-286132-ag2l1xa7 83 17 , , , cord-286132-ag2l1xa7 83 18 S6 S6 NNP cord-286132-ag2l1xa7 83 19 , , , cord-286132-ag2l1xa7 83 20 S8 S8 NNP cord-286132-ag2l1xa7 83 21 ) ) -RRB- cord-286132-ag2l1xa7 83 22 except except IN cord-286132-ag2l1xa7 83 23 the the DT cord-286132-ag2l1xa7 83 24 analysis analysis NN cord-286132-ag2l1xa7 83 25 17 17 CD cord-286132-ag2l1xa7 83 26 with with IN cord-286132-ag2l1xa7 83 27 0.5 0.5 CD cord-286132-ag2l1xa7 83 28 constant constant JJ cord-286132-ag2l1xa7 83 29 correction correction NN cord-286132-ag2l1xa7 83 30 of of IN cord-286132-ag2l1xa7 83 31 zero zero CD cord-286132-ag2l1xa7 83 32 - - HYPH cord-286132-ag2l1xa7 83 33 event event NN cord-286132-ag2l1xa7 83 34 studies study NNS cord-286132-ag2l1xa7 83 35 showed show VBD cord-286132-ag2l1xa7 83 36 a a DT cord-286132-ag2l1xa7 83 37 lower low JJR cord-286132-ag2l1xa7 83 38 risk risk NN cord-286132-ag2l1xa7 83 39 of of IN cord-286132-ag2l1xa7 83 40 infectious infectious JJ cord-286132-ag2l1xa7 83 41 pneumonia pneumonia NN cord-286132-ag2l1xa7 83 42 ( ( -LRB- cord-286132-ag2l1xa7 83 43 Table Table NNP cord-286132-ag2l1xa7 83 44 S3 S3 NNP cord-286132-ag2l1xa7 83 45 ) ) -RRB- cord-286132-ag2l1xa7 83 46 and and CC cord-286132-ag2l1xa7 83 47 Based base VBN cord-286132-ag2l1xa7 83 48 on on IN cord-286132-ag2l1xa7 83 49 the the DT cord-286132-ag2l1xa7 83 50 GRADE grade NN cord-286132-ag2l1xa7 83 51 , , , cord-286132-ag2l1xa7 83 52 an an DT cord-286132-ag2l1xa7 83 53 overall overall JJ cord-286132-ag2l1xa7 83 54 quality quality NN cord-286132-ag2l1xa7 83 55 of of IN cord-286132-ag2l1xa7 83 56 evidence evidence NN cord-286132-ag2l1xa7 83 57 for for IN cord-286132-ag2l1xa7 83 58 this this DT cord-286132-ag2l1xa7 83 59 analysis analysis NN cord-286132-ag2l1xa7 83 60 was be VBD cord-286132-ag2l1xa7 83 61 moderate moderate JJ cord-286132-ag2l1xa7 83 62 as as RB cord-286132-ag2l1xa7 83 63 infectious infectious JJ cord-286132-ag2l1xa7 83 64 3 3 CD cord-286132-ag2l1xa7 83 65 pneumonia pneumonia NN cord-286132-ag2l1xa7 83 66 and and CC cord-286132-ag2l1xa7 83 67 ILD ILD NNP cord-286132-ag2l1xa7 83 68 were be VBD cord-286132-ag2l1xa7 83 69 rare rare JJ cord-286132-ag2l1xa7 83 70 events event NNS cord-286132-ag2l1xa7 83 71 ( ( -LRB- cord-286132-ag2l1xa7 84 1 Tables Tables NNPS cord-286132-ag2l1xa7 84 2 S9 S9 NNP cord-286132-ag2l1xa7 84 3 and and CC cord-286132-ag2l1xa7 84 4 S10 S10 NNP cord-286132-ag2l1xa7 84 5 ) ) -RRB- cord-286132-ag2l1xa7 84 6 . . . cord-286132-ag2l1xa7 85 1 4 4 LS cord-286132-ag2l1xa7 86 1 Our -PRON- PRP$ cord-286132-ag2l1xa7 86 2 meta meta JJ cord-286132-ag2l1xa7 86 3 - - HYPH cord-286132-ag2l1xa7 86 4 analysis analysis NN cord-286132-ag2l1xa7 86 5 showed show VBD cord-286132-ag2l1xa7 86 6 that that IN cord-286132-ag2l1xa7 86 7 IL-12/23 il-12/23 NN cord-286132-ag2l1xa7 86 8 or or CC cord-286132-ag2l1xa7 86 9 IL-23 IL-23 NNP cord-286132-ag2l1xa7 86 10 inhibitors inhibitor NNS cord-286132-ag2l1xa7 86 11 increased increase VBD cord-286132-ag2l1xa7 86 12 the the DT cord-286132-ag2l1xa7 86 13 risk risk NN cord-286132-ag2l1xa7 86 14 of of IN cord-286132-ag2l1xa7 86 15 RTIs rti NNS cord-286132-ag2l1xa7 86 16 , , , cord-286132-ag2l1xa7 86 17 especially especially RB cord-286132-ag2l1xa7 86 18 2 2 CD cord-286132-ag2l1xa7 86 19 URTIs urti NNS cord-286132-ag2l1xa7 86 20 , , , cord-286132-ag2l1xa7 86 21 but but CC cord-286132-ag2l1xa7 86 22 not not RB cord-286132-ag2l1xa7 86 23 viral viral JJ cord-286132-ag2l1xa7 86 24 URTIs urti NNS cord-286132-ag2l1xa7 86 25 and and CC cord-286132-ag2l1xa7 86 26 LRTIs lrti NNS cord-286132-ag2l1xa7 86 27 , , , cord-286132-ag2l1xa7 86 28 and and CC cord-286132-ag2l1xa7 86 29 non non JJ cord-286132-ag2l1xa7 86 30 - - JJ cord-286132-ag2l1xa7 86 31 infectious infectious JJ cord-286132-ag2l1xa7 86 32 ILD ILD NNP cord-286132-ag2l1xa7 86 33 in in IN cord-286132-ag2l1xa7 86 34 autoimmune autoimmune JJ cord-286132-ag2l1xa7 86 35 diseases disease NNS cord-286132-ag2l1xa7 86 36 . . . cord-286132-ag2l1xa7 87 1 3 3 LS cord-286132-ag2l1xa7 88 1 We -PRON- PRP cord-286132-ag2l1xa7 88 2 found find VBD cord-286132-ag2l1xa7 88 3 that that IN cord-286132-ag2l1xa7 88 4 risankizumab risankizumab NN cord-286132-ag2l1xa7 88 5 and and CC cord-286132-ag2l1xa7 88 6 briakinumab briakinumab NN cord-286132-ag2l1xa7 88 7 particularly particularly RB cord-286132-ag2l1xa7 88 8 enhanced enhance VBD cord-286132-ag2l1xa7 88 9 the the DT cord-286132-ag2l1xa7 88 10 risk risk NN cord-286132-ag2l1xa7 88 11 of of IN cord-286132-ag2l1xa7 88 12 RTIs rti NNS cord-286132-ag2l1xa7 88 13 and and CC cord-286132-ag2l1xa7 88 14 4 4 CD cord-286132-ag2l1xa7 88 15 hypothesized hypothesize VBD cord-286132-ag2l1xa7 88 16 that that IN cord-286132-ag2l1xa7 88 17 concomitant concomitant JJ cord-286132-ag2l1xa7 88 18 therapies therapy NNS cord-286132-ag2l1xa7 88 19 during during IN cord-286132-ag2l1xa7 88 20 the the DT cord-286132-ag2l1xa7 88 21 trials trial NNS cord-286132-ag2l1xa7 88 22 might may MD cord-286132-ag2l1xa7 88 23 differentiate differentiate VB cord-286132-ag2l1xa7 88 24 the the DT cord-286132-ag2l1xa7 88 25 risk risk NN cord-286132-ag2l1xa7 88 26 of of IN cord-286132-ag2l1xa7 88 27 RTIs rti NNS cord-286132-ag2l1xa7 88 28 . . . cord-286132-ag2l1xa7 89 1 In in IN cord-286132-ag2l1xa7 89 2 terms term NNS cord-286132-ag2l1xa7 89 3 of of IN cord-286132-ag2l1xa7 89 4 5 5 CD cord-286132-ag2l1xa7 89 5 anti anti NNP cord-286132-ag2l1xa7 89 6 - - JJ cord-286132-ag2l1xa7 89 7 IL-23 IL-23 NNP cord-286132-ag2l1xa7 89 8 agents agent NNS cord-286132-ag2l1xa7 89 9 , , , cord-286132-ag2l1xa7 89 10 risankizumab risankizumab NNS cord-286132-ag2l1xa7 89 11 showed show VBD cord-286132-ag2l1xa7 89 12 a a DT cord-286132-ag2l1xa7 89 13 higher high JJR cord-286132-ag2l1xa7 89 14 rate rate NN cord-286132-ag2l1xa7 89 15 of of IN cord-286132-ag2l1xa7 89 16 RCTs rct NNS cord-286132-ag2l1xa7 89 17 which which WDT cord-286132-ag2l1xa7 89 18 permitted permit VBD cord-286132-ag2l1xa7 89 19 concomitant concomitant JJ cord-286132-ag2l1xa7 89 20 therapies therapy NNS cord-286132-ag2l1xa7 89 21 ( ( -LRB- cord-286132-ag2l1xa7 89 22 40.0 40.0 CD cord-286132-ag2l1xa7 89 23 % % NN cord-286132-ag2l1xa7 89 24 ) ) -RRB- cord-286132-ag2l1xa7 89 25 6 6 CD cord-286132-ag2l1xa7 89 26 compared compare VBN cord-286132-ag2l1xa7 89 27 with with IN cord-286132-ag2l1xa7 89 28 guselkumab guselkumab NNS cord-286132-ag2l1xa7 89 29 ( ( -LRB- cord-286132-ag2l1xa7 89 30 0 0 CD cord-286132-ag2l1xa7 89 31 % % NN cord-286132-ag2l1xa7 89 32 ) ) -RRB- cord-286132-ag2l1xa7 89 33 and and CC cord-286132-ag2l1xa7 89 34 tildrakizumab tildrakizumab NNP cord-286132-ag2l1xa7 89 35 ( ( -LRB- cord-286132-ag2l1xa7 89 36 0 0 CD cord-286132-ag2l1xa7 89 37 % % NN cord-286132-ag2l1xa7 89 38 ) ) -RRB- cord-286132-ag2l1xa7 89 39 . . . cord-286132-ag2l1xa7 90 1 Among among IN cord-286132-ag2l1xa7 90 2 RCTs rct NNS cord-286132-ag2l1xa7 90 3 of of IN cord-286132-ag2l1xa7 90 4 risankizumab risankizumab NNP cord-286132-ag2l1xa7 90 5 , , , cord-286132-ag2l1xa7 90 6 the the DT cord-286132-ag2l1xa7 90 7 only only JJ cord-286132-ag2l1xa7 90 8 study study NN cord-286132-ag2l1xa7 90 9 7 7 CD cord-286132-ag2l1xa7 90 10 reporting report VBG cord-286132-ag2l1xa7 90 11 an an DT cord-286132-ag2l1xa7 90 12 increased increase VBN cord-286132-ag2l1xa7 90 13 risk risk NN cord-286132-ag2l1xa7 90 14 of of IN cord-286132-ag2l1xa7 90 15 RTIs rti NNS cord-286132-ag2l1xa7 90 16 was be VBD cord-286132-ag2l1xa7 90 17 performed perform VBN cord-286132-ag2l1xa7 90 18 in in IN cord-286132-ag2l1xa7 90 19 patients patient NNS cord-286132-ag2l1xa7 90 20 with with IN cord-286132-ag2l1xa7 90 21 ankylosing ankylosing NNP cord-286132-ag2l1xa7 90 22 spondylitis spondylitis NN cord-286132-ag2l1xa7 90 23 who who WP cord-286132-ag2l1xa7 90 24 were be VBD cord-286132-ag2l1xa7 90 25 permitted permit VBN cord-286132-ag2l1xa7 90 26 8 8 CD cord-286132-ag2l1xa7 90 27 to to TO cord-286132-ag2l1xa7 90 28 use use VB cord-286132-ag2l1xa7 90 29 conventional conventional JJ cord-286132-ag2l1xa7 90 30 disease disease NN cord-286132-ag2l1xa7 90 31 - - HYPH cord-286132-ag2l1xa7 90 32 modifying modify VBG cord-286132-ag2l1xa7 90 33 antirheumatic antirheumatic JJ cord-286132-ag2l1xa7 90 34 drugs drug NNS cord-286132-ag2l1xa7 90 35 or or CC cord-286132-ag2l1xa7 90 36 low low JJ cord-286132-ag2l1xa7 90 37 - - HYPH cord-286132-ag2l1xa7 90 38 dose dose NN cord-286132-ag2l1xa7 90 39 systemic systemic JJ cord-286132-ag2l1xa7 90 40 steroids steroid NNS cord-286132-ag2l1xa7 90 41 . . . cord-286132-ag2l1xa7 91 1 36 36 CD cord-286132-ag2l1xa7 92 1 This this DT cord-286132-ag2l1xa7 92 2 suggests suggest VBZ cord-286132-ag2l1xa7 92 3 that that IN cord-286132-ag2l1xa7 92 4 9 9 CD cord-286132-ag2l1xa7 92 5 combination combination NN cord-286132-ag2l1xa7 92 6 therapy therapy NN cord-286132-ag2l1xa7 92 7 of of IN cord-286132-ag2l1xa7 92 8 anti anti NNP cord-286132-ag2l1xa7 92 9 - - JJ cord-286132-ag2l1xa7 92 10 IL-23 IL-23 NNP cord-286132-ag2l1xa7 92 11 agents agent NNS cord-286132-ag2l1xa7 92 12 with with IN cord-286132-ag2l1xa7 92 13 immunosuppressants immunosuppressant NNS cord-286132-ag2l1xa7 92 14 might may MD cord-286132-ag2l1xa7 92 15 work work VB cord-286132-ag2l1xa7 92 16 synergistically synergistically RB cord-286132-ag2l1xa7 92 17 to to TO cord-286132-ag2l1xa7 92 18 surface surface VB cord-286132-ag2l1xa7 92 19 the the DT cord-286132-ag2l1xa7 92 20 10 10 CD cord-286132-ag2l1xa7 92 21 risk risk NN cord-286132-ag2l1xa7 92 22 of of IN cord-286132-ag2l1xa7 92 23 RTIs rti NNS cord-286132-ag2l1xa7 92 24 . . . cord-286132-ag2l1xa7 93 1 As as IN cord-286132-ag2l1xa7 93 2 for for IN cord-286132-ag2l1xa7 93 3 anti anti JJ cord-286132-ag2l1xa7 93 4 - - JJ cord-286132-ag2l1xa7 93 5 IL-12 IL-12 NNP cord-286132-ag2l1xa7 93 6 / / SYM cord-286132-ag2l1xa7 93 7 IL-23 IL-23 NNP cord-286132-ag2l1xa7 93 8 agents agent NNS cord-286132-ag2l1xa7 93 9 , , , cord-286132-ag2l1xa7 93 10 each each DT cord-286132-ag2l1xa7 93 11 of of IN cord-286132-ag2l1xa7 93 12 briakinumab briakinumab NN cord-286132-ag2l1xa7 93 13 and and CC cord-286132-ag2l1xa7 93 14 ustekinumab ustekinumab NNP cord-286132-ag2l1xa7 93 15 has have VBZ cord-286132-ag2l1xa7 93 16 a a DT cord-286132-ag2l1xa7 93 17 similar similar JJ cord-286132-ag2l1xa7 93 18 percentage percentage NN cord-286132-ag2l1xa7 93 19 of of IN cord-286132-ag2l1xa7 93 20 11 11 CD cord-286132-ag2l1xa7 93 21 RCTs rct NNS cord-286132-ag2l1xa7 93 22 which which WDT cord-286132-ag2l1xa7 93 23 permitted permit VBD cord-286132-ag2l1xa7 93 24 concomitant concomitant JJ cord-286132-ag2l1xa7 93 25 drugs drug NNS cord-286132-ag2l1xa7 93 26 ( ( -LRB- cord-286132-ag2l1xa7 93 27 37.5 37.5 CD cord-286132-ag2l1xa7 93 28 % % NN cord-286132-ag2l1xa7 93 29 for for IN cord-286132-ag2l1xa7 93 30 briakinumab briakinumab NN cord-286132-ag2l1xa7 93 31 and and CC cord-286132-ag2l1xa7 93 32 38.5 38.5 CD cord-286132-ag2l1xa7 93 33 % % NN cord-286132-ag2l1xa7 93 34 for for IN cord-286132-ag2l1xa7 93 35 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 93 36 ) ) -RRB- cord-286132-ag2l1xa7 93 37 . . . cord-286132-ag2l1xa7 94 1 Other other JJ cord-286132-ag2l1xa7 94 2 12 12 CD cord-286132-ag2l1xa7 94 3 potential potential JJ cord-286132-ag2l1xa7 94 4 risk risk NN cord-286132-ag2l1xa7 94 5 factors factor NNS cord-286132-ag2l1xa7 94 6 such such JJ cord-286132-ag2l1xa7 94 7 as as IN cord-286132-ag2l1xa7 94 8 age age NN cord-286132-ag2l1xa7 94 9 and and CC cord-286132-ag2l1xa7 94 10 sex sex NN cord-286132-ag2l1xa7 94 11 were be VBD cord-286132-ag2l1xa7 94 12 not not RB cord-286132-ag2l1xa7 94 13 different different JJ cord-286132-ag2l1xa7 94 14 among among IN cord-286132-ag2l1xa7 94 15 the the DT cord-286132-ag2l1xa7 94 16 drugs drug NNS cord-286132-ag2l1xa7 94 17 . . . cord-286132-ag2l1xa7 95 1 Given give VBN cord-286132-ag2l1xa7 95 2 that that DT cord-286132-ag2l1xa7 95 3 briakinumab briakinumab NN cord-286132-ag2l1xa7 95 4 has have VBZ cord-286132-ag2l1xa7 95 5 13 13 CD cord-286132-ag2l1xa7 95 6 been be VBN cord-286132-ag2l1xa7 95 7 withdrawn withdraw VBN cord-286132-ag2l1xa7 95 8 from from IN cord-286132-ag2l1xa7 95 9 the the DT cord-286132-ag2l1xa7 95 10 application application NN cord-286132-ag2l1xa7 95 11 with with IN cord-286132-ag2l1xa7 95 12 FDA FDA NNP cord-286132-ag2l1xa7 95 13 due due JJ cord-286132-ag2l1xa7 95 14 to to IN cord-286132-ag2l1xa7 95 15 severe severe JJ cord-286132-ag2l1xa7 95 16 adverse adverse JJ cord-286132-ag2l1xa7 95 17 events event NNS cord-286132-ag2l1xa7 95 18 , , , cord-286132-ag2l1xa7 95 19 1 1 CD cord-286132-ag2l1xa7 95 20 the the DT cord-286132-ag2l1xa7 95 21 difference difference NN cord-286132-ag2l1xa7 95 22 in in IN cord-286132-ag2l1xa7 95 23 risk risk NN cord-286132-ag2l1xa7 95 24 of of IN cord-286132-ag2l1xa7 95 25 RTIs rti NNS cord-286132-ag2l1xa7 95 26 14 14 CD cord-286132-ag2l1xa7 95 27 among among IN cord-286132-ag2l1xa7 95 28 two two CD cord-286132-ag2l1xa7 95 29 drugs drug NNS cord-286132-ag2l1xa7 95 30 would would MD cord-286132-ag2l1xa7 95 31 be be VB cord-286132-ag2l1xa7 95 32 explained explain VBN cord-286132-ag2l1xa7 95 33 by by IN cord-286132-ag2l1xa7 95 34 different different JJ cord-286132-ag2l1xa7 95 35 properties property NNS cord-286132-ag2l1xa7 95 36 of of IN cord-286132-ag2l1xa7 95 37 these these DT cord-286132-ag2l1xa7 95 38 drugs drug NNS cord-286132-ag2l1xa7 95 39 . . . cord-286132-ag2l1xa7 96 1 15 15 CD cord-286132-ag2l1xa7 97 1 Our -PRON- PRP$ cord-286132-ag2l1xa7 97 2 study study NN cord-286132-ag2l1xa7 97 3 might may MD cord-286132-ag2l1xa7 97 4 support support VB cord-286132-ag2l1xa7 97 5 that that IN cord-286132-ag2l1xa7 97 6 anti anti NNS cord-286132-ag2l1xa7 97 7 - - JJ cord-286132-ag2l1xa7 97 8 IL-12/23 il-12/23 JJ cord-286132-ag2l1xa7 97 9 and and CC cord-286132-ag2l1xa7 97 10 anti anti JJ cord-286132-ag2l1xa7 97 11 - - JJ cord-286132-ag2l1xa7 97 12 IL-23 il-23 JJ cord-286132-ag2l1xa7 97 13 therapies therapy NNS cord-286132-ag2l1xa7 97 14 can can MD cord-286132-ag2l1xa7 97 15 be be VB cord-286132-ag2l1xa7 97 16 safely safely RB cord-286132-ag2l1xa7 97 17 used use VBN cord-286132-ag2l1xa7 97 18 for for IN cord-286132-ag2l1xa7 97 19 16 16 CD cord-286132-ag2l1xa7 97 20 autoimmune autoimmune JJ cord-286132-ag2l1xa7 97 21 diseases disease NNS cord-286132-ag2l1xa7 97 22 even even RB cord-286132-ag2l1xa7 97 23 during during IN cord-286132-ag2l1xa7 97 24 the the DT cord-286132-ag2l1xa7 97 25 current current JJ cord-286132-ag2l1xa7 97 26 COVID-19 COVID-19 NNP cord-286132-ag2l1xa7 97 27 pandemic pandemic NN cord-286132-ag2l1xa7 97 28 . . . cord-286132-ag2l1xa7 98 1 However however RB cord-286132-ag2l1xa7 98 2 , , , cord-286132-ag2l1xa7 98 3 given give VBN cord-286132-ag2l1xa7 98 4 that that IN cord-286132-ag2l1xa7 98 5 influenza influenza NN cord-286132-ag2l1xa7 98 6 Respiratory Respiratory NNP cord-286132-ag2l1xa7 98 7 Syndrome Syndrome NNP cord-286132-ag2l1xa7 98 8 coronavirus coronavirus NN cord-286132-ag2l1xa7 98 9 showed show VBD cord-286132-ag2l1xa7 98 10 that that IN cord-286132-ag2l1xa7 98 11 a a DT cord-286132-ag2l1xa7 98 12 patient patient NN cord-286132-ag2l1xa7 98 13 with with IN cord-286132-ag2l1xa7 98 14 a a DT cord-286132-ag2l1xa7 98 15 poor poor JJ cord-286132-ag2l1xa7 98 16 outcome outcome NN cord-286132-ag2l1xa7 98 17 had have VBD cord-286132-ag2l1xa7 98 18 an an DT cord-286132-ag2l1xa7 98 19 increased increase VBN cord-286132-ag2l1xa7 98 20 level level NN cord-286132-ag2l1xa7 98 21 of of IN cord-286132-ag2l1xa7 98 22 IL- il- CD cord-286132-ag2l1xa7 98 23 17 17 CD cord-286132-ag2l1xa7 98 24 15 15 CD cord-286132-ag2l1xa7 98 25 expression expression NN cord-286132-ag2l1xa7 98 26 in in IN cord-286132-ag2l1xa7 98 27 the the DT cord-286132-ag2l1xa7 98 28 lung lung NN cord-286132-ag2l1xa7 98 29 . . . cord-286132-ag2l1xa7 99 1 41 41 CD cord-286132-ag2l1xa7 100 1 These these DT cord-286132-ag2l1xa7 100 2 data datum NNS cord-286132-ag2l1xa7 100 3 suggest suggest VBP cord-286132-ag2l1xa7 100 4 that that IN cord-286132-ag2l1xa7 100 5 IL-12/23 il-12/23 NN cord-286132-ag2l1xa7 100 6 or or CC cord-286132-ag2l1xa7 100 7 IL-23 IL-23 NNP cord-286132-ag2l1xa7 100 8 inhibitors inhibitor NNS cord-286132-ag2l1xa7 100 9 might may MD cord-286132-ag2l1xa7 100 10 theoretically theoretically RB cord-286132-ag2l1xa7 100 11 be be VB cord-286132-ag2l1xa7 100 12 preventive preventive JJ cord-286132-ag2l1xa7 100 13 16 16 CD cord-286132-ag2l1xa7 100 14 for for IN cord-286132-ag2l1xa7 100 15 SARS SARS NNP cord-286132-ag2l1xa7 100 16 - - HYPH cord-286132-ag2l1xa7 100 17 CoV-2-induced cov-2-induce VBN cord-286132-ag2l1xa7 100 18 pneumonia pneumonia NN cord-286132-ag2l1xa7 100 19 rather rather RB cord-286132-ag2l1xa7 100 20 than than IN cord-286132-ag2l1xa7 100 21 detrimental detrimental JJ cord-286132-ag2l1xa7 100 22 in in IN cord-286132-ag2l1xa7 100 23 autoimmune autoimmune JJ cord-286132-ag2l1xa7 100 24 diseases disease NNS cord-286132-ag2l1xa7 100 25 during during IN cord-286132-ag2l1xa7 100 26 the the DT cord-286132-ag2l1xa7 100 27 COVID- covid- NN cord-286132-ag2l1xa7 100 28 19 19 CD cord-286132-ag2l1xa7 100 29 17 17 CD cord-286132-ag2l1xa7 100 30 pandemic pandemic NN cord-286132-ag2l1xa7 100 31 . . . cord-286132-ag2l1xa7 101 1 18 18 CD cord-286132-ag2l1xa7 102 1 First first RB cord-286132-ag2l1xa7 102 2 , , , cord-286132-ag2l1xa7 102 3 this this DT cord-286132-ag2l1xa7 102 4 study study NN cord-286132-ag2l1xa7 102 5 did do VBD cord-286132-ag2l1xa7 102 6 not not RB cord-286132-ag2l1xa7 102 7 assess assess VB cord-286132-ag2l1xa7 102 8 the the DT cord-286132-ag2l1xa7 102 9 long long JJ cord-286132-ag2l1xa7 102 10 - - HYPH cord-286132-ag2l1xa7 102 11 term term NN cord-286132-ag2l1xa7 102 12 effect effect NN cord-286132-ag2l1xa7 102 13 of of IN cord-286132-ag2l1xa7 102 14 IL-12/23 il-12/23 NN cord-286132-ag2l1xa7 102 15 or or CC cord-286132-ag2l1xa7 102 16 IL-23 IL-23 NNP cord-286132-ag2l1xa7 102 17 antagonists antagonist NNS cord-286132-ag2l1xa7 102 18 on on IN cord-286132-ag2l1xa7 102 19 RTIs rti NNS cord-286132-ag2l1xa7 102 20 and and CC cord-286132-ag2l1xa7 102 21 2 2 CD cord-286132-ag2l1xa7 102 22 ILD ILD NNP cord-286132-ag2l1xa7 102 23 . . . cord-286132-ag2l1xa7 103 1 However however RB cord-286132-ag2l1xa7 103 2 , , , cord-286132-ag2l1xa7 103 3 92.6 92.6 CD cord-286132-ag2l1xa7 103 4 % % NN cord-286132-ag2l1xa7 103 5 ( ( -LRB- cord-286132-ag2l1xa7 103 6 50/54 50/54 CD cord-286132-ag2l1xa7 103 7 ) ) -RRB- cord-286132-ag2l1xa7 103 8 of of IN cord-286132-ag2l1xa7 103 9 included include VBN cord-286132-ag2l1xa7 103 10 studies study NNS cord-286132-ag2l1xa7 103 11 reported report VBD cord-286132-ag2l1xa7 103 12 RTIs rti NNS cord-286132-ag2l1xa7 103 13 during during IN cord-286132-ag2l1xa7 103 14 placebo placebo NN cord-286132-ag2l1xa7 103 15 - - HYPH cord-286132-ag2l1xa7 103 16 controlled control VBN cord-286132-ag2l1xa7 103 17 phases phase NNS cord-286132-ag2l1xa7 103 18 . . . cord-286132-ag2l1xa7 104 1 FDA FDA NNP cord-286132-ag2l1xa7 104 2 3 3 CD cord-286132-ag2l1xa7 104 3 reported report VBD cord-286132-ag2l1xa7 104 4 the the DT cord-286132-ag2l1xa7 104 5 onset onset NN cord-286132-ag2l1xa7 104 6 of of IN cord-286132-ag2l1xa7 104 7 ILD ILD NNP cord-286132-ag2l1xa7 104 8 was be VBD cord-286132-ag2l1xa7 104 9 acute acute JJ cord-286132-ag2l1xa7 104 10 or or CC cord-286132-ag2l1xa7 104 11 subacute subacute JJ cord-286132-ag2l1xa7 104 12 , , , cord-286132-ag2l1xa7 105 1 14 14 CD cord-286132-ag2l1xa7 105 2 so so RB cord-286132-ag2l1xa7 105 3 our -PRON- PRP$ cord-286132-ag2l1xa7 105 4 data datum NNS cord-286132-ag2l1xa7 105 5 would would MD cord-286132-ag2l1xa7 105 6 most most RBS cord-286132-ag2l1xa7 105 7 likely likely RB cord-286132-ag2l1xa7 105 8 include include VB cord-286132-ag2l1xa7 105 9 the the DT cord-286132-ag2l1xa7 105 10 incidence incidence NN cord-286132-ag2l1xa7 105 11 of of IN cord-286132-ag2l1xa7 105 12 these these DT cord-286132-ag2l1xa7 105 13 4 4 CD cord-286132-ag2l1xa7 105 14 events event NNS cord-286132-ag2l1xa7 105 15 . . . cord-286132-ag2l1xa7 106 1 Second second RB cord-286132-ag2l1xa7 106 2 , , , cord-286132-ag2l1xa7 106 3 regarding regard VBG cord-286132-ag2l1xa7 106 4 infectious infectious JJ cord-286132-ag2l1xa7 106 5 pneumonia pneumonia NN cord-286132-ag2l1xa7 106 6 and and CC cord-286132-ag2l1xa7 106 7 ILD ILD NNP cord-286132-ag2l1xa7 106 8 , , , cord-286132-ag2l1xa7 106 9 many many JJ cord-286132-ag2l1xa7 106 10 studies study NNS cord-286132-ag2l1xa7 106 11 had have VBD cord-286132-ag2l1xa7 106 12 both both DT cord-286132-ag2l1xa7 106 13 - - HYPH cord-286132-ag2l1xa7 106 14 armed armed JJ cord-286132-ag2l1xa7 106 15 zero zero CD cord-286132-ag2l1xa7 106 16 - - HYPH cord-286132-ag2l1xa7 106 17 event event NN cord-286132-ag2l1xa7 106 18 ( ( -LRB- cord-286132-ag2l1xa7 106 19 87 87 CD cord-286132-ag2l1xa7 106 20 % % NN cord-286132-ag2l1xa7 106 21 5 5 CD cord-286132-ag2l1xa7 106 22 ( ( -LRB- cord-286132-ag2l1xa7 106 23 47/54 47/54 CD cord-286132-ag2l1xa7 106 24 ) ) -RRB- cord-286132-ag2l1xa7 106 25 and and CC cord-286132-ag2l1xa7 106 26 94 94 CD cord-286132-ag2l1xa7 106 27 % % NN cord-286132-ag2l1xa7 106 28 ( ( -LRB- cord-286132-ag2l1xa7 106 29 51/54 51/54 CD cord-286132-ag2l1xa7 106 30 ) ) -RRB- cord-286132-ag2l1xa7 106 31 , , , cord-286132-ag2l1xa7 106 32 respectively respectively RB cord-286132-ag2l1xa7 106 33 ) ) -RRB- cord-286132-ag2l1xa7 106 34 . . . cord-286132-ag2l1xa7 107 1 Thus thus RB cord-286132-ag2l1xa7 107 2 , , , cord-286132-ag2l1xa7 107 3 we -PRON- PRP cord-286132-ag2l1xa7 107 4 undertook undertake VBD cord-286132-ag2l1xa7 107 5 comprehensive comprehensive JJ cord-286132-ag2l1xa7 107 6 analyses analysis NNS cord-286132-ag2l1xa7 107 7 that that WDT cord-286132-ag2l1xa7 107 8 either either CC cord-286132-ag2l1xa7 107 9 included include VBD cord-286132-ag2l1xa7 107 10 or or CC cord-286132-ag2l1xa7 107 11 6 6 CD cord-286132-ag2l1xa7 107 12 excluded exclude VBN cord-286132-ag2l1xa7 107 13 double double JJ cord-286132-ag2l1xa7 107 14 - - HYPH cord-286132-ag2l1xa7 107 15 zero zero CD cord-286132-ag2l1xa7 107 16 - - HYPH cord-286132-ag2l1xa7 107 17 event event NN cord-286132-ag2l1xa7 107 18 studies study NNS cord-286132-ag2l1xa7 107 19 . . . cord-286132-ag2l1xa7 108 1 The the DT cord-286132-ag2l1xa7 108 2 analysis analysis NN cord-286132-ag2l1xa7 108 3 with with IN cord-286132-ag2l1xa7 108 4 0.5 0.5 CD cord-286132-ag2l1xa7 108 5 constant constant JJ cord-286132-ag2l1xa7 108 6 correction correction NN cord-286132-ag2l1xa7 108 7 showed show VBD cord-286132-ag2l1xa7 108 8 a a DT cord-286132-ag2l1xa7 108 9 lower low JJR cord-286132-ag2l1xa7 108 10 risk risk NN cord-286132-ag2l1xa7 108 11 of of IN cord-286132-ag2l1xa7 108 12 these these DT cord-286132-ag2l1xa7 108 13 7 7 CD cord-286132-ag2l1xa7 108 14 events event NNS cord-286132-ag2l1xa7 108 15 in in IN cord-286132-ag2l1xa7 108 16 the the DT cord-286132-ag2l1xa7 108 17 treatment treatment NN cord-286132-ag2l1xa7 108 18 group group NN cord-286132-ag2l1xa7 108 19 . . . cord-286132-ag2l1xa7 109 1 We -PRON- PRP cord-286132-ag2l1xa7 109 2 also also RB cord-286132-ag2l1xa7 109 3 used use VBD cord-286132-ag2l1xa7 109 4 treatment treatment NN cord-286132-ag2l1xa7 109 5 arm arm NN cord-286132-ag2l1xa7 109 6 correction correction NN cord-286132-ag2l1xa7 109 7 because because IN cord-286132-ag2l1xa7 109 8 this this DT cord-286132-ag2l1xa7 109 9 method method NN cord-286132-ag2l1xa7 109 10 performed perform VBN cord-286132-ag2l1xa7 109 11 better well JJR cord-286132-ag2l1xa7 109 12 8 8 CD cord-286132-ag2l1xa7 109 13 than than IN cord-286132-ag2l1xa7 109 14 0.5 0.5 CD cord-286132-ag2l1xa7 109 15 constant constant JJ cord-286132-ag2l1xa7 109 16 correction correction NN cord-286132-ag2l1xa7 109 17 to to TO cord-286132-ag2l1xa7 109 18 examine examine VB cord-286132-ag2l1xa7 109 19 rare rare JJ cord-286132-ag2l1xa7 109 20 events event NNS cord-286132-ag2l1xa7 109 21 . . . cord-286132-ag2l1xa7 110 1 46 46 CD cord-286132-ag2l1xa7 110 2 Third Third NNP cord-286132-ag2l1xa7 110 3 , , , cord-286132-ag2l1xa7 110 4 our -PRON- PRP$ cord-286132-ag2l1xa7 110 5 study study NN cord-286132-ag2l1xa7 110 6 may may MD cord-286132-ag2l1xa7 110 7 not not RB cord-286132-ag2l1xa7 110 8 reflect reflect VB cord-286132-ag2l1xa7 110 9 the the DT cord-286132-ag2l1xa7 110 10 risk risk NN cord-286132-ag2l1xa7 110 11 in in IN cord-286132-ag2l1xa7 110 12 patients patient NNS cord-286132-ag2l1xa7 110 13 at at IN cord-286132-ag2l1xa7 110 14 9 9 CD cord-286132-ag2l1xa7 110 15 high high JJ cord-286132-ag2l1xa7 110 16 risk risk NN cord-286132-ag2l1xa7 110 17 for for IN cord-286132-ag2l1xa7 110 18 RTIs rti NNS cord-286132-ag2l1xa7 110 19 due due IN cord-286132-ag2l1xa7 110 20 to to IN cord-286132-ag2l1xa7 110 21 the the DT cord-286132-ag2l1xa7 110 22 possible possible JJ cord-286132-ag2l1xa7 110 23 exclusion exclusion NN cord-286132-ag2l1xa7 110 24 of of IN cord-286132-ag2l1xa7 110 25 patients patient NNS cord-286132-ag2l1xa7 110 26 with with IN cord-286132-ag2l1xa7 110 27 recent recent JJ cord-286132-ag2l1xa7 110 28 RTIs rti NNS cord-286132-ag2l1xa7 110 29 or or CC cord-286132-ag2l1xa7 110 30 chronic chronic JJ cord-286132-ag2l1xa7 110 31 lung lung NN cord-286132-ag2l1xa7 110 32 disease disease NN cord-286132-ag2l1xa7 110 33 in in IN cord-286132-ag2l1xa7 110 34 clinical clinical JJ cord-286132-ag2l1xa7 110 35 10 10 CD cord-286132-ag2l1xa7 110 36 trials trial NNS cord-286132-ag2l1xa7 110 37 . . . cord-286132-ag2l1xa7 111 1 Fourth fourth RB cord-286132-ag2l1xa7 111 2 , , , cord-286132-ag2l1xa7 111 3 we -PRON- PRP cord-286132-ag2l1xa7 111 4 categorized categorize VBD cord-286132-ag2l1xa7 111 5 RTIs rti NNS cord-286132-ag2l1xa7 111 6 into into IN cord-286132-ag2l1xa7 111 7 URTIs urti NNS cord-286132-ag2l1xa7 111 8 , , , cord-286132-ag2l1xa7 111 9 viral viral JJ cord-286132-ag2l1xa7 111 10 URTIs urti NNS cord-286132-ag2l1xa7 111 11 , , , cord-286132-ag2l1xa7 111 12 and and CC cord-286132-ag2l1xa7 111 13 LRTIs LRTIs NNP cord-286132-ag2l1xa7 111 14 based base VBN cord-286132-ag2l1xa7 111 15 on on IN cord-286132-ag2l1xa7 111 16 MedDRA MedDRA NNS cord-286132-ag2l1xa7 111 17 which which WDT cord-286132-ag2l1xa7 111 18 is be VBZ cord-286132-ag2l1xa7 111 19 widely widely RB cord-286132-ag2l1xa7 111 20 11 11 CD cord-286132-ag2l1xa7 111 21 used use VBN cord-286132-ag2l1xa7 111 22 in in IN cord-286132-ag2l1xa7 111 23 clinical clinical JJ cord-286132-ag2l1xa7 111 24 trials trial NNS cord-286132-ag2l1xa7 111 25 , , , cord-286132-ag2l1xa7 111 26 but but CC cord-286132-ag2l1xa7 111 27 not not RB cord-286132-ag2l1xa7 111 28 so so RB cord-286132-ag2l1xa7 111 29 much much RB cord-286132-ag2l1xa7 111 30 in in IN cord-286132-ag2l1xa7 111 31 clinical clinical JJ cord-286132-ag2l1xa7 111 32 research research NN cord-286132-ag2l1xa7 111 33 . . . cord-286132-ag2l1xa7 112 1 Furthermore furthermore RB cord-286132-ag2l1xa7 112 2 , , , cord-286132-ag2l1xa7 112 3 the the DT cord-286132-ag2l1xa7 112 4 included include VBN cord-286132-ag2l1xa7 112 5 studies study NNS cord-286132-ag2l1xa7 112 6 have have VBP cord-286132-ag2l1xa7 112 7 been be VBN cord-286132-ag2l1xa7 112 8 12 12 CD cord-286132-ag2l1xa7 112 9 conducted conduct VBN cord-286132-ag2l1xa7 112 10 before before IN cord-286132-ag2l1xa7 112 11 the the DT cord-286132-ag2l1xa7 112 12 pandemic pandemic NN cord-286132-ag2l1xa7 112 13 . . . cord-286132-ag2l1xa7 113 1 Hence hence RB cord-286132-ag2l1xa7 113 2 , , , cord-286132-ag2l1xa7 113 3 it -PRON- PRP cord-286132-ag2l1xa7 113 4 does do VBZ cord-286132-ag2l1xa7 113 5 not not RB cord-286132-ag2l1xa7 113 6 provide provide VB cord-286132-ag2l1xa7 113 7 evidences evidence NNS cord-286132-ag2l1xa7 113 8 whether whether IN cord-286132-ag2l1xa7 113 9 there there EX cord-286132-ag2l1xa7 113 10 is be VBZ cord-286132-ag2l1xa7 113 11 an an DT cord-286132-ag2l1xa7 113 12 increase increase NN cord-286132-ag2l1xa7 113 13 in in IN cord-286132-ag2l1xa7 113 14 RTIs rti NNS cord-286132-ag2l1xa7 113 15 or or CC cord-286132-ag2l1xa7 113 16 13 13 CD cord-286132-ag2l1xa7 113 17 ILD ILD NNP cord-286132-ag2l1xa7 113 18 during during IN cord-286132-ag2l1xa7 113 19 the the DT cord-286132-ag2l1xa7 113 20 pandemic pandemic NN cord-286132-ag2l1xa7 113 21 in in IN cord-286132-ag2l1xa7 113 22 patients patient NNS cord-286132-ag2l1xa7 113 23 receiving receive VBG cord-286132-ag2l1xa7 113 24 IL-12/23 il-12/23 NN cord-286132-ag2l1xa7 113 25 or or CC cord-286132-ag2l1xa7 113 26 IL-23 IL-23 NNP cord-286132-ag2l1xa7 113 27 antagonists antagonist NNS cord-286132-ag2l1xa7 113 28 , , , cord-286132-ag2l1xa7 113 29 nor nor CC cord-286132-ag2l1xa7 113 30 whether whether IN cord-286132-ag2l1xa7 113 31 these these DT cord-286132-ag2l1xa7 113 32 agents agent NNS cord-286132-ag2l1xa7 113 33 can can MD cord-286132-ag2l1xa7 113 34 be be VB cord-286132-ag2l1xa7 113 35 14 14 CD cord-286132-ag2l1xa7 113 36 autoimmune autoimmune JJ cord-286132-ag2l1xa7 113 37 diseases disease NNS cord-286132-ag2l1xa7 113 38 is be VBZ cord-286132-ag2l1xa7 113 39 needed need VBN cord-286132-ag2l1xa7 113 40 . . . cord-286132-ag2l1xa7 114 1 20 20 CD cord-286132-ag2l1xa7 115 1 Nemoto Nemoto NNP cord-286132-ag2l1xa7 115 2 et et NNP cord-286132-ag2l1xa7 115 3 al al NNP cord-286132-ag2l1xa7 115 4 2018 2018 CD cord-286132-ag2l1xa7 115 5 48 48 CD cord-286132-ag2l1xa7 115 6 Blauvelt Blauvelt NNP cord-286132-ag2l1xa7 115 7 et et NNP cord-286132-ag2l1xa7 115 8 al al NNP cord-286132-ag2l1xa7 115 9 2017 2017 CD cord-286132-ag2l1xa7 115 10 49 49 CD cord-286132-ag2l1xa7 115 11 Reich Reich NNP cord-286132-ag2l1xa7 115 12 et et NNP cord-286132-ag2l1xa7 115 13 al al NNP cord-286132-ag2l1xa7 115 14 2017 2017 CD cord-286132-ag2l1xa7 115 15 10 10 CD cord-286132-ag2l1xa7 115 16 Gordon Gordon NNP cord-286132-ag2l1xa7 115 17 et et NNP cord-286132-ag2l1xa7 115 18 al al NNP cord-286132-ag2l1xa7 115 19 2015 2015 CD cord-286132-ag2l1xa7 115 20 9 9 CD cord-286132-ag2l1xa7 115 21 Sofen Sofen NNP cord-286132-ag2l1xa7 115 22 et et FW cord-286132-ag2l1xa7 115 23 al al NNP cord-286132-ag2l1xa7 116 1 2014 2014 CD cord-286132-ag2l1xa7 116 2 50 50 CD cord-286132-ag2l1xa7 116 3 Terui Terui NNP cord-286132-ag2l1xa7 116 4 et et NNP cord-286132-ag2l1xa7 116 5 al al NNP cord-286132-ag2l1xa7 116 6 2018 2018 CD cord-286132-ag2l1xa7 116 7 51 51 CD cord-286132-ag2l1xa7 116 8 [ [ -LRB- cord-286132-ag2l1xa7 116 9 wt>100 wt>100 NNP cord-286132-ag2l1xa7 116 10 kg kg NNP cord-286132-ag2l1xa7 116 11 ] ] -RRB- cord-286132-ag2l1xa7 117 1 at at IN cord-286132-ag2l1xa7 117 2 wk wk NN cord-286132-ag2l1xa7 117 3 0,4 0,4 CD cord-286132-ag2l1xa7 117 4 45 45 CD cord-286132-ag2l1xa7 117 5 s.c.at s.c.at NN cord-286132-ag2l1xa7 117 6 wk wk XX cord-286132-ag2l1xa7 117 7 0,4 0,4 CD cord-286132-ag2l1xa7 118 1 33 33 CD cord-286132-ag2l1xa7 118 2 Tsai Tsai NNP cord-286132-ag2l1xa7 118 3 et et NNP cord-286132-ag2l1xa7 118 4 al al NNP cord-286132-ag2l1xa7 118 5 2011 2011 CD cord-286132-ag2l1xa7 119 1 63 63 CD cord-286132-ag2l1xa7 119 2 Papp Papp NNP cord-286132-ag2l1xa7 119 3 et et NNP cord-286132-ag2l1xa7 119 4 al al NNP cord-286132-ag2l1xa7 119 5 2008 2008 CD cord-286132-ag2l1xa7 119 6 3 3 CD cord-286132-ag2l1xa7 119 7 Leonardi Leonardi NNP cord-286132-ag2l1xa7 119 8 et et NNP cord-286132-ag2l1xa7 119 9 al al NNP cord-286132-ag2l1xa7 119 10 2008 2008 CD cord-286132-ag2l1xa7 119 11 64 64 CD cord-286132-ag2l1xa7 119 12 Krueger Krueger NNP cord-286132-ag2l1xa7 119 13 et et NNP cord-286132-ag2l1xa7 119 14 al al NNP cord-286132-ag2l1xa7 119 15 2007 2007 CD cord-286132-ag2l1xa7 120 1 65 65 CD cord-286132-ag2l1xa7 120 2 Ritchlin Ritchlin NNP cord-286132-ag2l1xa7 120 3 et et NNP cord-286132-ag2l1xa7 120 4 al al NNP cord-286132-ag2l1xa7 120 5 2014 2014 CD cord-286132-ag2l1xa7 121 1 34 34 CD cord-286132-ag2l1xa7 121 2 Mclnne Mclnne NNP cord-286132-ag2l1xa7 121 3 et et NNP cord-286132-ag2l1xa7 121 4 al al NNP cord-286132-ag2l1xa7 121 5 2013 2013 CD cord-286132-ag2l1xa7 121 6 66 66 CD cord-286132-ag2l1xa7 121 7 Gottlieb Gottlieb NNP cord-286132-ag2l1xa7 121 8 et et NNP cord-286132-ag2l1xa7 121 9 al al NNP cord-286132-ag2l1xa7 121 10 2009 2009 CD cord-286132-ag2l1xa7 121 11 67 67 CD cord-286132-ag2l1xa7 122 1 Feagan Feagan NNP cord-286132-ag2l1xa7 122 2 et et FW cord-286132-ag2l1xa7 122 3 al al NNP cord-286132-ag2l1xa7 122 4 2016 2016 CD cord-286132-ag2l1xa7 123 1 68 68 CD cord-286132-ag2l1xa7 123 2 Feagan Feagan NNP cord-286132-ag2l1xa7 123 3 et et NNP cord-286132-ag2l1xa7 123 4 al al NNP cord-286132-ag2l1xa7 123 5 2016 2016 CD cord-286132-ag2l1xa7 124 1 68 68 CD cord-286132-ag2l1xa7 124 2 Sandborn Sandborn NNP cord-286132-ag2l1xa7 124 3 et et NNP cord-286132-ag2l1xa7 124 4 al al NNP cord-286132-ag2l1xa7 124 5 2012 2012 CD cord-286132-ag2l1xa7 124 6 4 4 CD cord-286132-ag2l1xa7 124 7 Sandborn Sandborn NNP cord-286132-ag2l1xa7 124 8 et et NNP cord-286132-ag2l1xa7 124 9 al al NNP cord-286132-ag2l1xa7 124 10 2008 2008 CD cord-286132-ag2l1xa7 124 11 69 69 CD cord-286132-ag2l1xa7 124 12 Khattri Khattri NNP cord-286132-ag2l1xa7 124 13 et et FW cord-286132-ag2l1xa7 124 14 al al NNP cord-286132-ag2l1xa7 125 1 2017 2017 CD cord-286132-ag2l1xa7 125 2 70 70 CD cord-286132-ag2l1xa7 125 3 Saeki Saeki NNP cord-286132-ag2l1xa7 125 4 _SP cord-286132-ag2l1xa7 125 5 ( ( -LRB- cord-286132-ag2l1xa7 125 6 s s NN cord-286132-ag2l1xa7 125 7 ) ) -RRB- cord-286132-ag2l1xa7 125 8 130 130 CD cord-286132-ag2l1xa7 125 9 , , , cord-286132-ag2l1xa7 126 1 6mg 6mg NN cord-286132-ag2l1xa7 126 2 / / SYM cord-286132-ag2l1xa7 126 3 kg kg NNP cord-286132-ag2l1xa7 126 4 i.v i.v NNP cord-286132-ag2l1xa7 126 5 . . . cord-286132-ag2l1xa7 127 1 ( ( -LRB- cord-286132-ag2l1xa7 127 2 s s NN cord-286132-ag2l1xa7 127 3 ) ) -RRB- cord-286132-ag2l1xa7 127 4 1 1 CD cord-286132-ag2l1xa7 127 5 , , , cord-286132-ag2l1xa7 127 6 3 3 CD cord-286132-ag2l1xa7 127 7 , , , cord-286132-ag2l1xa7 128 1 6mg 6mg NN cord-286132-ag2l1xa7 128 2 / / SYM cord-286132-ag2l1xa7 128 3 kg kg NNP cord-286132-ag2l1xa7 128 4 i.v i.v NNP cord-286132-ag2l1xa7 128 5 . . . cord-286132-ag2l1xa7 129 1 ( ( -LRB- cord-286132-ag2l1xa7 129 2 s s NN cord-286132-ag2l1xa7 129 3 ) ) -RRB- cord-286132-ag2l1xa7 130 1 90 90 CD cord-286132-ag2l1xa7 130 2 s.c s.c NNP cord-286132-ag2l1xa7 130 3 A A NNP cord-286132-ag2l1xa7 130 4 phase phase NN cord-286132-ag2l1xa7 130 5 III iii CD cord-286132-ag2l1xa7 130 6 , , , cord-286132-ag2l1xa7 130 7 randomized randomized JJ cord-286132-ag2l1xa7 130 8 mAb mab NN cord-286132-ag2l1xa7 130 9 briakinumab briakinumab NNS cord-286132-ag2l1xa7 130 10 in in IN cord-286132-ag2l1xa7 130 11 moderate moderate JJ cord-286132-ag2l1xa7 130 12 - - HYPH cord-286132-ag2l1xa7 130 13 to to IN cord-286132-ag2l1xa7 130 14 - - HYPH cord-286132-ag2l1xa7 130 15 severe severe JJ cord-286132-ag2l1xa7 130 16 psoriasis psoriasis NN cord-286132-ag2l1xa7 130 17 Briakinumab Briakinumab NNP cord-286132-ag2l1xa7 130 18 for for IN cord-286132-ag2l1xa7 130 19 treatment treatment NN cord-286132-ag2l1xa7 130 20 of of IN cord-286132-ag2l1xa7 130 21 Crohn Crohn NNP cord-286132-ag2l1xa7 130 22 's 's POS cord-286132-ag2l1xa7 130 23 disease disease NN cord-286132-ag2l1xa7 130 24 : : : cord-286132-ag2l1xa7 130 25 results result NNS cord-286132-ag2l1xa7 130 26 of of IN cord-286132-ag2l1xa7 130 27 a a DT cord-286132-ag2l1xa7 130 28 randomized randomized JJ cord-286132-ag2l1xa7 130 29 trial trial NN cord-286132-ag2l1xa7 130 30 Efficacy Efficacy NNP cord-286132-ag2l1xa7 130 31 and and CC cord-286132-ag2l1xa7 130 32 safety safety NN cord-286132-ag2l1xa7 130 33 of of IN cord-286132-ag2l1xa7 130 34 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 130 35 , , , cord-286132-ag2l1xa7 130 36 a a DT cord-286132-ag2l1xa7 130 37 human human JJ cord-286132-ag2l1xa7 130 38 interleukin-12/23 interleukin-12/23 NNP cord-286132-ag2l1xa7 130 39 monoclonal monoclonal JJ cord-286132-ag2l1xa7 130 40 antibody antibody NN cord-286132-ag2l1xa7 130 41 , , , cord-286132-ag2l1xa7 130 42 in in IN cord-286132-ag2l1xa7 130 43 patients patient NNS cord-286132-ag2l1xa7 130 44 with with IN cord-286132-ag2l1xa7 130 45 psoriasis psoriasis NN cord-286132-ag2l1xa7 130 46 : : : cord-286132-ag2l1xa7 130 47 52-week 52-week CD cord-286132-ag2l1xa7 130 48 results result NNS cord-286132-ag2l1xa7 130 49 from from IN cord-286132-ag2l1xa7 130 50 a a DT cord-286132-ag2l1xa7 130 51 randomised randomised JJ cord-286132-ag2l1xa7 130 52 , , , cord-286132-ag2l1xa7 130 53 double double JJ cord-286132-ag2l1xa7 130 54 - - HYPH cord-286132-ag2l1xa7 130 55 blind blind JJ cord-286132-ag2l1xa7 130 56 , , , cord-286132-ag2l1xa7 130 57 placebo placebo NN cord-286132-ag2l1xa7 130 58 - - HYPH cord-286132-ag2l1xa7 130 59 controlled control VBN cord-286132-ag2l1xa7 130 60 trial trial NN cord-286132-ag2l1xa7 130 61 ( ( -LRB- cord-286132-ag2l1xa7 130 62 PHOENIX PHOENIX NNP cord-286132-ag2l1xa7 130 63 2 2 CD cord-286132-ag2l1xa7 130 64 ) ) -RRB- cord-286132-ag2l1xa7 130 65 Ustekinumab Ustekinumab NNP cord-286132-ag2l1xa7 130 66 induction induction NN cord-286132-ag2l1xa7 130 67 and and CC cord-286132-ag2l1xa7 130 68 maintenance maintenance NN cord-286132-ag2l1xa7 130 69 therapy therapy NN cord-286132-ag2l1xa7 130 70 in in IN cord-286132-ag2l1xa7 130 71 refractory refractory JJ cord-286132-ag2l1xa7 130 72 Crohn Crohn NNP cord-286132-ag2l1xa7 130 73 's 's POS cord-286132-ag2l1xa7 130 74 disease disease NN cord-286132-ag2l1xa7 130 75 Tildrakizumab Tildrakizumab NNP cord-286132-ag2l1xa7 130 76 versus versus IN cord-286132-ag2l1xa7 130 77 placebo placebo NN cord-286132-ag2l1xa7 130 78 or or CC cord-286132-ag2l1xa7 130 79 etanercept etanercept VBN cord-286132-ag2l1xa7 130 80 for for IN cord-286132-ag2l1xa7 130 81 chronic chronic JJ cord-286132-ag2l1xa7 130 82 plaque plaque NN cord-286132-ag2l1xa7 130 83 psoriasis psoriasis NN cord-286132-ag2l1xa7 131 1 ( ( -LRB- cord-286132-ag2l1xa7 131 2 reSURFACE reSURFACE NNP cord-286132-ag2l1xa7 131 3 1 1 CD cord-286132-ag2l1xa7 131 4 and and CC cord-286132-ag2l1xa7 131 5 reSURFACE reSURFACE NNP cord-286132-ag2l1xa7 131 6 2 2 CD cord-286132-ag2l1xa7 131 7 ) ) -RRB- cord-286132-ag2l1xa7 132 1 : : : cord-286132-ag2l1xa7 132 2 results result NNS cord-286132-ag2l1xa7 132 3 from from IN cord-286132-ag2l1xa7 132 4 two two CD cord-286132-ag2l1xa7 132 5 randomised randomised JJ cord-286132-ag2l1xa7 132 6 controlled control VBN cord-286132-ag2l1xa7 132 7 , , , cord-286132-ag2l1xa7 132 8 phase phase NN cord-286132-ag2l1xa7 132 9 3 3 CD cord-286132-ag2l1xa7 132 10 trials trial NNS cord-286132-ag2l1xa7 132 11 MK-3222 MK-3222 NNP cord-286132-ag2l1xa7 132 12 ) ) -RRB- cord-286132-ag2l1xa7 132 13 , , , cord-286132-ag2l1xa7 132 14 an an DT cord-286132-ag2l1xa7 132 15 anti anti NN cord-286132-ag2l1xa7 132 16 - - JJ cord-286132-ag2l1xa7 132 17 interleukin-23p19 interleukin-23p19 JJ cord-286132-ag2l1xa7 132 18 monoclonal monoclonal JJ cord-286132-ag2l1xa7 132 19 antibody antibody NN cord-286132-ag2l1xa7 132 20 , , , cord-286132-ag2l1xa7 132 21 improves improve VBZ cord-286132-ag2l1xa7 132 22 psoriasis psoriasis NN cord-286132-ag2l1xa7 132 23 in in IN cord-286132-ag2l1xa7 132 24 a a DT cord-286132-ag2l1xa7 132 25 phase phase NN cord-286132-ag2l1xa7 133 1 IIb IIb NNP cord-286132-ag2l1xa7 133 2 randomized randomize VBD cord-286132-ag2l1xa7 133 3 placebo placebo NN cord-286132-ag2l1xa7 133 4 - - HYPH cord-286132-ag2l1xa7 133 5 controlled control VBN cord-286132-ag2l1xa7 133 6 trial trial NN cord-286132-ag2l1xa7 133 7 Efficacy Efficacy NNP cord-286132-ag2l1xa7 133 8 and and CC cord-286132-ag2l1xa7 133 9 safety safety NN cord-286132-ag2l1xa7 133 10 of of IN cord-286132-ag2l1xa7 133 11 risankizumab risankizumab NNS cord-286132-ag2l1xa7 133 12 in in IN cord-286132-ag2l1xa7 133 13 moderate moderate JJ cord-286132-ag2l1xa7 133 14 - - HYPH cord-286132-ag2l1xa7 133 15 to to IN cord-286132-ag2l1xa7 133 16 - - HYPH cord-286132-ag2l1xa7 133 17 severe severe JJ cord-286132-ag2l1xa7 133 18 plaque plaque NN cord-286132-ag2l1xa7 133 19 psoriasis psoriasis NN cord-286132-ag2l1xa7 133 20 ( ( -LRB- cord-286132-ag2l1xa7 133 21 UltIMMa-1 ultimma-1 NN cord-286132-ag2l1xa7 133 22 and and CC cord-286132-ag2l1xa7 133 23 UltIMMa-2 ultimma-2 NN cord-286132-ag2l1xa7 133 24 ) ) -RRB- cord-286132-ag2l1xa7 134 1 : : : cord-286132-ag2l1xa7 134 2 results result NNS cord-286132-ag2l1xa7 134 3 from from IN cord-286132-ag2l1xa7 134 4 two two CD cord-286132-ag2l1xa7 134 5 double double JJ cord-286132-ag2l1xa7 134 6 - - HYPH cord-286132-ag2l1xa7 134 7 blind blind JJ cord-286132-ag2l1xa7 134 8 , , , cord-286132-ag2l1xa7 134 9 randomised randomised JJ cord-286132-ag2l1xa7 134 10 , , , cord-286132-ag2l1xa7 134 11 placebo placebo NN cord-286132-ag2l1xa7 134 12 - - HYPH cord-286132-ag2l1xa7 134 13 controlled control VBN cord-286132-ag2l1xa7 134 14 and and CC cord-286132-ag2l1xa7 134 15 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 134 16 - - HYPH cord-286132-ag2l1xa7 134 17 controlled control VBN cord-286132-ag2l1xa7 134 18 phase phase NN cord-286132-ag2l1xa7 134 19 3 3 CD cord-286132-ag2l1xa7 134 20 trials trial NNS cord-286132-ag2l1xa7 135 1 Induction induction NN cord-286132-ag2l1xa7 135 2 therapy therapy NN cord-286132-ag2l1xa7 135 3 with with IN cord-286132-ag2l1xa7 135 4 the the DT cord-286132-ag2l1xa7 135 5 selective selective JJ cord-286132-ag2l1xa7 135 6 interleukin-23 interleukin-23 NN cord-286132-ag2l1xa7 135 7 inhibitor inhibitor NN cord-286132-ag2l1xa7 135 8 risankizumab risankizumab NNS cord-286132-ag2l1xa7 135 9 in in IN cord-286132-ag2l1xa7 135 10 patients patient NNS cord-286132-ag2l1xa7 135 11 with with IN cord-286132-ag2l1xa7 135 12 moderate moderate JJ cord-286132-ag2l1xa7 135 13 - - HYPH cord-286132-ag2l1xa7 135 14 to to IN cord-286132-ag2l1xa7 135 15 - - HYPH cord-286132-ag2l1xa7 135 16 severe severe JJ cord-286132-ag2l1xa7 135 17 Crohn Crohn NNP cord-286132-ag2l1xa7 135 18 's 's POS cord-286132-ag2l1xa7 135 19 disease disease NN cord-286132-ag2l1xa7 135 20 : : : cord-286132-ag2l1xa7 135 21 a a DT cord-286132-ag2l1xa7 135 22 randomised randomised JJ cord-286132-ag2l1xa7 135 23 , , , cord-286132-ag2l1xa7 135 24 double double JJ cord-286132-ag2l1xa7 135 25 - - HYPH cord-286132-ag2l1xa7 135 26 blind blind JJ cord-286132-ag2l1xa7 135 27 , , , cord-286132-ag2l1xa7 135 28 placebo placebo NN cord-286132-ag2l1xa7 135 29 - - HYPH cord-286132-ag2l1xa7 135 30 controlled control VBN cord-286132-ag2l1xa7 135 31 phase phase NN cord-286132-ag2l1xa7 135 32 2 2 CD cord-286132-ag2l1xa7 135 33 study study NN cord-286132-ag2l1xa7 136 1 A a DT cord-286132-ag2l1xa7 136 2 Phase phase NN cord-286132-ag2l1xa7 136 3 2 2 CD cord-286132-ag2l1xa7 136 4 Trial trial NN cord-286132-ag2l1xa7 136 5 of of IN cord-286132-ag2l1xa7 136 6 Guselkumab Guselkumab NNP cord-286132-ag2l1xa7 136 7 versus versus IN cord-286132-ag2l1xa7 136 8 Adalimumab Adalimumab NNP cord-286132-ag2l1xa7 136 9 for for IN cord-286132-ag2l1xa7 136 10 Plaque Plaque NNP cord-286132-ag2l1xa7 136 11 Psoriasis Psoriasis NNP cord-286132-ag2l1xa7 136 12 Efficacy Efficacy NNP cord-286132-ag2l1xa7 136 13 and and CC cord-286132-ag2l1xa7 136 14 safety safety NN cord-286132-ag2l1xa7 136 15 of of IN cord-286132-ag2l1xa7 136 16 guselkumab guselkumab NNS cord-286132-ag2l1xa7 136 17 , , , cord-286132-ag2l1xa7 136 18 an an DT cord-286132-ag2l1xa7 136 19 anti anti JJ cord-286132-ag2l1xa7 136 20 - - JJ cord-286132-ag2l1xa7 136 21 interleukin-23 interleukin-23 JJ cord-286132-ag2l1xa7 136 22 monoclonal monoclonal JJ cord-286132-ag2l1xa7 136 23 antibody antibody NN cord-286132-ag2l1xa7 136 24 , , , cord-286132-ag2l1xa7 136 25 compared compare VBN cord-286132-ag2l1xa7 136 26 with with IN cord-286132-ag2l1xa7 136 27 adalimumab adalimumab NNS cord-286132-ag2l1xa7 136 28 for for IN cord-286132-ag2l1xa7 136 29 the the DT cord-286132-ag2l1xa7 136 30 treatment treatment NN cord-286132-ag2l1xa7 136 31 of of IN cord-286132-ag2l1xa7 136 32 patients patient NNS cord-286132-ag2l1xa7 136 33 with with IN cord-286132-ag2l1xa7 136 34 moderate moderate JJ cord-286132-ag2l1xa7 136 35 to to IN cord-286132-ag2l1xa7 136 36 severe severe JJ cord-286132-ag2l1xa7 136 37 psoriasis psoriasis NN cord-286132-ag2l1xa7 136 38 with with IN cord-286132-ag2l1xa7 136 39 randomized randomized JJ cord-286132-ag2l1xa7 136 40 withdrawal withdrawal NN cord-286132-ag2l1xa7 136 41 and and CC cord-286132-ag2l1xa7 136 42 retreatment retreatment NN cord-286132-ag2l1xa7 136 43 : : : cord-286132-ag2l1xa7 136 44 Results result NNS cord-286132-ag2l1xa7 136 45 from from IN cord-286132-ag2l1xa7 136 46 the the DT cord-286132-ag2l1xa7 136 47 phase phase NN cord-286132-ag2l1xa7 136 48 III iii CD cord-286132-ag2l1xa7 136 49 , , , cord-286132-ag2l1xa7 136 50 double double JJ cord-286132-ag2l1xa7 136 51 - - HYPH cord-286132-ag2l1xa7 136 52 blind blind JJ cord-286132-ag2l1xa7 136 53 , , , cord-286132-ag2l1xa7 136 54 placebo placebo NN cord-286132-ag2l1xa7 136 55 - - HYPH cord-286132-ag2l1xa7 136 56 and and CC cord-286132-ag2l1xa7 136 57 active active JJ cord-286132-ag2l1xa7 136 58 comparator comparator NN cord-286132-ag2l1xa7 136 59 - - HYPH cord-286132-ag2l1xa7 136 60 controlled control VBN cord-286132-ag2l1xa7 136 61 VOYAGE voyage NN cord-286132-ag2l1xa7 136 62 2 2 CD cord-286132-ag2l1xa7 136 63 trial trial NN cord-286132-ag2l1xa7 136 64 Efficacy Efficacy NNP cord-286132-ag2l1xa7 136 65 and and CC cord-286132-ag2l1xa7 136 66 Safety Safety NNP cord-286132-ag2l1xa7 136 67 of of IN cord-286132-ag2l1xa7 136 68 MEDI2070 MEDI2070 NNP cord-286132-ag2l1xa7 136 69 , , , cord-286132-ag2l1xa7 136 70 an an DT cord-286132-ag2l1xa7 136 71 Patients patient NNS cord-286132-ag2l1xa7 136 72 With with IN cord-286132-ag2l1xa7 136 73 Moderate moderate JJ cord-286132-ag2l1xa7 136 74 to to IN cord-286132-ag2l1xa7 136 75 Severe severe JJ cord-286132-ag2l1xa7 136 76 Crohn Crohn NNP cord-286132-ag2l1xa7 136 77 's 's POS cord-286132-ag2l1xa7 136 78 Disease Disease NNP cord-286132-ag2l1xa7 136 79 : : : cord-286132-ag2l1xa7 137 1 A a DT cord-286132-ag2l1xa7 137 2 Phase Phase NNP cord-286132-ag2l1xa7 137 3 2a 2a CD cord-286132-ag2l1xa7 137 4 Study Study NNP cord-286132-ag2l1xa7 137 5 Crohn Crohn NNP cord-286132-ag2l1xa7 137 6 's 's POS cord-286132-ag2l1xa7 137 7 disease disease NN cord-286132-ag2l1xa7 137 8 Disease Disease NNP cord-286132-ag2l1xa7 137 9 Coverage Coverage NNP cord-286132-ag2l1xa7 138 1 The the DT cord-286132-ag2l1xa7 138 2 safety safety NN cord-286132-ag2l1xa7 138 3 of of IN cord-286132-ag2l1xa7 138 4 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 138 5 for for IN cord-286132-ag2l1xa7 138 6 the the DT cord-286132-ag2l1xa7 138 7 treatment treatment NN cord-286132-ag2l1xa7 138 8 of of IN cord-286132-ag2l1xa7 138 9 psoriatic psoriatic JJ cord-286132-ag2l1xa7 138 10 arthritis arthritis NN cord-286132-ag2l1xa7 138 11 Association Association NNP cord-286132-ag2l1xa7 138 12 of of IN cord-286132-ag2l1xa7 138 13 Noninfectious Noninfectious NNP cord-286132-ag2l1xa7 138 14 Pneumonia Pneumonia NNP cord-286132-ag2l1xa7 138 15 With with IN cord-286132-ag2l1xa7 138 16 Ustekinumab Ustekinumab NNP cord-286132-ag2l1xa7 138 17 Use Use NNP cord-286132-ag2l1xa7 138 18 Editorial editorial NN cord-286132-ag2l1xa7 138 19 : : : cord-286132-ag2l1xa7 138 20 The the DT cord-286132-ag2l1xa7 138 21 explosive explosive JJ cord-286132-ag2l1xa7 138 22 epidemic epidemic NN cord-286132-ag2l1xa7 138 23 outbreak outbreak NN cord-286132-ag2l1xa7 138 24 of of IN cord-286132-ag2l1xa7 138 25 novel novel JJ cord-286132-ag2l1xa7 138 26 coronavirus coronavirus NN cord-286132-ag2l1xa7 138 27 disease disease NN cord-286132-ag2l1xa7 138 28 COVID-19 COVID-19 NNP cord-286132-ag2l1xa7 138 29 ) ) -RRB- cord-286132-ag2l1xa7 138 30 and and CC cord-286132-ag2l1xa7 138 31 the the DT cord-286132-ag2l1xa7 138 32 persistent persistent JJ cord-286132-ag2l1xa7 138 33 threat threat NN cord-286132-ag2l1xa7 138 34 of of IN cord-286132-ag2l1xa7 138 35 respiratory respiratory JJ cord-286132-ag2l1xa7 138 36 tract tract NN cord-286132-ag2l1xa7 138 37 infectious infectious JJ cord-286132-ag2l1xa7 138 38 diseases disease NNS cord-286132-ag2l1xa7 138 39 to to IN cord-286132-ag2l1xa7 138 40 global global JJ cord-286132-ag2l1xa7 138 41 health health NN cord-286132-ag2l1xa7 138 42 security security NN cord-286132-ag2l1xa7 138 43 Should Should MD cord-286132-ag2l1xa7 138 44 biologics biologic NNS cord-286132-ag2l1xa7 138 45 for for IN cord-286132-ag2l1xa7 138 46 psoriasis psoriasis NN cord-286132-ag2l1xa7 138 47 be be VB cord-286132-ag2l1xa7 138 48 interrupted interrupt VBN cord-286132-ag2l1xa7 138 49 in in IN cord-286132-ag2l1xa7 138 50 the the DT cord-286132-ag2l1xa7 138 51 era era NN cord-286132-ag2l1xa7 138 52 of of IN cord-286132-ag2l1xa7 138 53 COVID-19 COVID-19 NNP cord-286132-ag2l1xa7 138 54 ? ? . cord-286132-ag2l1xa7 139 1 Are be VBP cord-286132-ag2l1xa7 139 2 patients patient NNS cord-286132-ag2l1xa7 139 3 with with IN cord-286132-ag2l1xa7 139 4 inflammatory inflammatory JJ cord-286132-ag2l1xa7 139 5 bowel bowel NN cord-286132-ag2l1xa7 139 6 disease disease NN cord-286132-ag2l1xa7 139 7 at at IN cord-286132-ag2l1xa7 139 8 increased increase VBN cord-286132-ag2l1xa7 139 9 risk risk NN cord-286132-ag2l1xa7 139 10 for for IN cord-286132-ag2l1xa7 139 11 Covid-19 covid-19 NN cord-286132-ag2l1xa7 139 12 infection infection NN cord-286132-ag2l1xa7 139 13 ? ? . cord-286132-ag2l1xa7 140 1 Preferred preferred JJ cord-286132-ag2l1xa7 140 2 reporting reporting NN cord-286132-ag2l1xa7 140 3 items item NNS cord-286132-ag2l1xa7 140 4 for for IN cord-286132-ag2l1xa7 140 5 systematic systematic JJ cord-286132-ag2l1xa7 140 6 reviews review NNS cord-286132-ag2l1xa7 140 7 and and CC cord-286132-ag2l1xa7 140 8 meta meta NNP cord-286132-ag2l1xa7 140 9 - - HYPH cord-286132-ag2l1xa7 140 10 analyses analysis NNS cord-286132-ag2l1xa7 140 11 : : : cord-286132-ag2l1xa7 141 1 the the DT cord-286132-ag2l1xa7 141 2 PRISMA PRISMA NNP cord-286132-ag2l1xa7 141 3 statement statement NN cord-286132-ag2l1xa7 141 4 PROSPERO PROSPERO NNP cord-286132-ag2l1xa7 141 5 's 's POS cord-286132-ag2l1xa7 141 6 progress progress NN cord-286132-ag2l1xa7 141 7 and and CC cord-286132-ag2l1xa7 141 8 activities activity NNS cord-286132-ag2l1xa7 141 9 2012/13 2012/13 CD cord-286132-ag2l1xa7 141 10 Efficacy Efficacy NNP cord-286132-ag2l1xa7 141 11 and and CC cord-286132-ag2l1xa7 141 12 safety safety NN cord-286132-ag2l1xa7 141 13 of of IN cord-286132-ag2l1xa7 141 14 guselkumab guselkumab NNS cord-286132-ag2l1xa7 141 15 , , , cord-286132-ag2l1xa7 141 16 administered administer VBN cord-286132-ag2l1xa7 141 17 with with IN cord-286132-ag2l1xa7 141 18 a a DT cord-286132-ag2l1xa7 141 19 novel novel JJ cord-286132-ag2l1xa7 141 20 patient patient NN cord-286132-ag2l1xa7 141 21 - - HYPH cord-286132-ag2l1xa7 141 22 controlled control VBN cord-286132-ag2l1xa7 141 23 injector injector NN cord-286132-ag2l1xa7 141 24 ( ( -LRB- cord-286132-ag2l1xa7 141 25 One one CD cord-286132-ag2l1xa7 141 26 - - HYPH cord-286132-ag2l1xa7 141 27 Press Press NNP cord-286132-ag2l1xa7 141 28 ) ) -RRB- cord-286132-ag2l1xa7 141 29 , , , cord-286132-ag2l1xa7 141 30 for for IN cord-286132-ag2l1xa7 141 31 moderate moderate JJ cord-286132-ag2l1xa7 141 32 - - HYPH cord-286132-ag2l1xa7 141 33 to to IN cord-286132-ag2l1xa7 141 34 - - HYPH cord-286132-ag2l1xa7 141 35 severe severe JJ cord-286132-ag2l1xa7 141 36 psoriasis psoriasis NN cord-286132-ag2l1xa7 141 37 : : : cord-286132-ag2l1xa7 141 38 results result NNS cord-286132-ag2l1xa7 141 39 from from IN cord-286132-ag2l1xa7 141 40 the the DT cord-286132-ag2l1xa7 141 41 phase phase NN cord-286132-ag2l1xa7 141 42 3 3 CD cord-286132-ag2l1xa7 141 43 ORION ORION NNP cord-286132-ag2l1xa7 141 44 study study NN cord-286132-ag2l1xa7 142 1 In in IN cord-286132-ag2l1xa7 143 1 vivo vivo NNP cord-286132-ag2l1xa7 143 2 IL-12 IL-12 NNP cord-286132-ag2l1xa7 143 3 / / SYM cord-286132-ag2l1xa7 143 4 IL-23p40 il-23p40 CD cord-286132-ag2l1xa7 143 5 neutralization neutralization NN cord-286132-ag2l1xa7 143 6 blocks block NNS cord-286132-ag2l1xa7 144 1 Th1 Th1 NNP cord-286132-ag2l1xa7 144 2 / / SYM cord-286132-ag2l1xa7 144 3 Th17 th17 CD cord-286132-ag2l1xa7 144 4 response response NN cord-286132-ag2l1xa7 144 5 after after IN cord-286132-ag2l1xa7 144 6 allogeneic allogeneic JJ cord-286132-ag2l1xa7 144 7 hematopoietic hematopoietic JJ cord-286132-ag2l1xa7 144 8 cell cell NN cord-286132-ag2l1xa7 144 9 transplantation transplantation NN cord-286132-ag2l1xa7 144 10 Assessing assess VBG cord-286132-ag2l1xa7 144 11 the the DT cord-286132-ag2l1xa7 144 12 quality quality NN cord-286132-ag2l1xa7 144 13 of of IN cord-286132-ag2l1xa7 144 14 reports report NNS cord-286132-ag2l1xa7 144 15 of of IN cord-286132-ag2l1xa7 144 16 randomized randomized JJ cord-286132-ag2l1xa7 144 17 clinical clinical JJ cord-286132-ag2l1xa7 144 18 trials trial NNS cord-286132-ag2l1xa7 144 19 : : : cord-286132-ag2l1xa7 144 20 is be VBZ cord-286132-ag2l1xa7 144 21 blinding blind VBG cord-286132-ag2l1xa7 144 22 necessary necessary JJ cord-286132-ag2l1xa7 144 23 ? ? . cord-286132-ag2l1xa7 145 1 The the DT cord-286132-ag2l1xa7 145 2 Cochrane Cochrane NNP cord-286132-ag2l1xa7 145 3 Collaboration Collaboration NNP cord-286132-ag2l1xa7 145 4 's 's POS cord-286132-ag2l1xa7 145 5 tool tool NN cord-286132-ag2l1xa7 145 6 for for IN cord-286132-ag2l1xa7 145 7 assessing assess VBG cord-286132-ag2l1xa7 145 8 risk risk NN cord-286132-ag2l1xa7 145 9 of of IN cord-286132-ag2l1xa7 145 10 bias bias NN cord-286132-ag2l1xa7 145 11 in in IN cord-286132-ag2l1xa7 145 12 randomised randomised JJ cord-286132-ag2l1xa7 145 13 trials trial NNS cord-286132-ag2l1xa7 145 14 GRADE grade NN cord-286132-ag2l1xa7 145 15 guidelines guideline NNS cord-286132-ag2l1xa7 145 16 : : : cord-286132-ag2l1xa7 145 17 4 4 CD cord-286132-ag2l1xa7 145 18 . . . cord-286132-ag2l1xa7 146 1 Rating rate VBG cord-286132-ag2l1xa7 146 2 the the DT cord-286132-ag2l1xa7 146 3 quality quality NN cord-286132-ag2l1xa7 146 4 of of IN cord-286132-ag2l1xa7 146 5 evidence evidence NN cord-286132-ag2l1xa7 146 6 -- -- : cord-286132-ag2l1xa7 146 7 study study NN cord-286132-ag2l1xa7 146 8 limitations limitation NNS cord-286132-ag2l1xa7 146 9 ( ( -LRB- cord-286132-ag2l1xa7 146 10 risk risk NN cord-286132-ag2l1xa7 146 11 of of IN cord-286132-ag2l1xa7 146 12 bias bias NN cord-286132-ag2l1xa7 146 13 ) ) -RRB- cord-286132-ag2l1xa7 147 1 Inclusion inclusion NN cord-286132-ag2l1xa7 147 2 of of IN cord-286132-ag2l1xa7 147 3 zero zero CD cord-286132-ag2l1xa7 147 4 total total JJ cord-286132-ag2l1xa7 147 5 event event NN cord-286132-ag2l1xa7 147 6 trials trial NNS cord-286132-ag2l1xa7 147 7 in in IN cord-286132-ag2l1xa7 147 8 meta meta NNP cord-286132-ag2l1xa7 147 9 - - HYPH cord-286132-ag2l1xa7 147 10 analyses analysis NNS cord-286132-ag2l1xa7 147 11 maintains maintain VBZ cord-286132-ag2l1xa7 147 12 analytic analytic JJ cord-286132-ag2l1xa7 147 13 consistency consistency NN cord-286132-ag2l1xa7 147 14 and and CC cord-286132-ag2l1xa7 147 15 incorporates incorporate VBZ cord-286132-ag2l1xa7 147 16 all all DT cord-286132-ag2l1xa7 147 17 available available JJ cord-286132-ag2l1xa7 147 18 data datum NNS cord-286132-ag2l1xa7 147 19 The the DT cord-286132-ag2l1xa7 147 20 Peto Peto NNP cord-286132-ag2l1xa7 147 21 odds odd NNS cord-286132-ag2l1xa7 147 22 ratio ratio NN cord-286132-ag2l1xa7 147 23 viewed view VBN cord-286132-ag2l1xa7 147 24 as as IN cord-286132-ag2l1xa7 147 25 a a DT cord-286132-ag2l1xa7 147 26 new new JJ cord-286132-ag2l1xa7 147 27 effect effect NN cord-286132-ag2l1xa7 147 28 measure measure NN cord-286132-ag2l1xa7 147 29 Methods method NNS cord-286132-ag2l1xa7 147 30 for for IN cord-286132-ag2l1xa7 147 31 pooled pool VBN cord-286132-ag2l1xa7 147 32 analyses analysis NNS cord-286132-ag2l1xa7 147 33 of of IN cord-286132-ag2l1xa7 147 34 epidemiologic epidemiologic JJ cord-286132-ag2l1xa7 147 35 studies study NNS cord-286132-ag2l1xa7 147 36 Anti Anti NNP cord-286132-ag2l1xa7 147 37 - - NNP cord-286132-ag2l1xa7 147 38 TNF TNF NNP cord-286132-ag2l1xa7 147 39 antibody antibody NN cord-286132-ag2l1xa7 147 40 therapy therapy NN cord-286132-ag2l1xa7 147 41 in in IN cord-286132-ag2l1xa7 147 42 rheumatoid rheumatoid JJ cord-286132-ag2l1xa7 147 43 arthritis arthritis NN cord-286132-ag2l1xa7 147 44 and and CC cord-286132-ag2l1xa7 147 45 the the DT cord-286132-ag2l1xa7 147 46 risk risk NN cord-286132-ag2l1xa7 147 47 of of IN cord-286132-ag2l1xa7 147 48 serious serious JJ cord-286132-ag2l1xa7 147 49 infections infection NNS cord-286132-ag2l1xa7 147 50 and and CC cord-286132-ag2l1xa7 147 51 malignancies malignancy NNS cord-286132-ag2l1xa7 147 52 : : : cord-286132-ag2l1xa7 147 53 systematic systematic JJ cord-286132-ag2l1xa7 147 54 review review NN cord-286132-ag2l1xa7 147 55 and and CC cord-286132-ag2l1xa7 147 56 meta meta NNP cord-286132-ag2l1xa7 147 57 - - HYPH cord-286132-ag2l1xa7 147 58 analysis analysis NN cord-286132-ag2l1xa7 147 59 of of IN cord-286132-ag2l1xa7 147 60 rare rare JJ cord-286132-ag2l1xa7 147 61 harmful harmful JJ cord-286132-ag2l1xa7 147 62 effects effect NNS cord-286132-ag2l1xa7 147 63 in in IN cord-286132-ag2l1xa7 147 64 randomized randomized JJ cord-286132-ag2l1xa7 147 65 controlled control VBN cord-286132-ag2l1xa7 147 66 trials trial NNS cord-286132-ag2l1xa7 148 1 Measuring measure VBG cord-286132-ag2l1xa7 148 2 inconsistency inconsistency NN cord-286132-ag2l1xa7 148 3 in in IN cord-286132-ag2l1xa7 148 4 meta meta NNP cord-286132-ag2l1xa7 148 5 - - HYPH cord-286132-ag2l1xa7 148 6 analyses analysis NNS cord-286132-ag2l1xa7 148 7 Cochrane Cochrane NNP cord-286132-ag2l1xa7 148 8 Handbook Handbook NNP cord-286132-ag2l1xa7 148 9 for for IN cord-286132-ag2l1xa7 148 10 Systematic Systematic NNP cord-286132-ag2l1xa7 148 11 Reviews Reviews NNPS cord-286132-ag2l1xa7 148 12 of of IN cord-286132-ag2l1xa7 148 13 Interventions Interventions NNPS cord-286132-ag2l1xa7 148 14 , , , cord-286132-ag2l1xa7 148 15 Version Version NNP cord-286132-ag2l1xa7 148 16 5.1 5.1 CD cord-286132-ag2l1xa7 148 17 . . . cord-286132-ag2l1xa7 148 18 0 0 NFP cord-286132-ag2l1xa7 148 19 . . . cord-286132-ag2l1xa7 149 1 London London NNP cord-286132-ag2l1xa7 149 2 The the DT cord-286132-ag2l1xa7 149 3 Cochrane Cochrane NNP cord-286132-ag2l1xa7 149 4 Collaboration Collaboration NNP cord-286132-ag2l1xa7 149 5 Operating Operating NNP cord-286132-ag2l1xa7 149 6 characteristics characteristic NNS cord-286132-ag2l1xa7 149 7 of of IN cord-286132-ag2l1xa7 149 8 a a DT cord-286132-ag2l1xa7 149 9 rank rank NN cord-286132-ag2l1xa7 149 10 correlation correlation NN cord-286132-ag2l1xa7 149 11 test test NN cord-286132-ag2l1xa7 149 12 for for IN cord-286132-ag2l1xa7 149 13 publication publication NN cord-286132-ag2l1xa7 149 14 bias bias NN cord-286132-ag2l1xa7 149 15 Bias Bias NNP cord-286132-ag2l1xa7 149 16 in in IN cord-286132-ag2l1xa7 149 17 meta meta NNP cord-286132-ag2l1xa7 149 18 - - HYPH cord-286132-ag2l1xa7 149 19 analysis analysis NN cord-286132-ag2l1xa7 149 20 detected detect VBN cord-286132-ag2l1xa7 149 21 by by IN cord-286132-ag2l1xa7 149 22 a a DT cord-286132-ag2l1xa7 149 23 simple simple JJ cord-286132-ag2l1xa7 149 24 , , , cord-286132-ag2l1xa7 149 25 graphical graphical JJ cord-286132-ag2l1xa7 149 26 test test NN cord-286132-ag2l1xa7 149 27 Efficacy Efficacy NNP cord-286132-ag2l1xa7 149 28 and and CC cord-286132-ag2l1xa7 149 29 safety safety NN cord-286132-ag2l1xa7 149 30 of of IN cord-286132-ag2l1xa7 149 31 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 149 32 in in IN cord-286132-ag2l1xa7 149 33 Japanese japanese JJ cord-286132-ag2l1xa7 149 34 patients patient NNS cord-286132-ag2l1xa7 149 35 with with IN cord-286132-ag2l1xa7 149 36 moderate moderate JJ cord-286132-ag2l1xa7 149 37 - - HYPH cord-286132-ag2l1xa7 149 38 to to IN cord-286132-ag2l1xa7 149 39 - - HYPH cord-286132-ag2l1xa7 149 40 severe severe JJ cord-286132-ag2l1xa7 149 41 plaque plaque NN cord-286132-ag2l1xa7 149 42 - - HYPH cord-286132-ag2l1xa7 149 43 type type NN cord-286132-ag2l1xa7 149 44 psoriasis psoriasis NN cord-286132-ag2l1xa7 149 45 : : : cord-286132-ag2l1xa7 149 46 long long JJ cord-286132-ag2l1xa7 149 47 - - HYPH cord-286132-ag2l1xa7 149 48 term term NN cord-286132-ag2l1xa7 149 49 results result NNS cord-286132-ag2l1xa7 149 50 from from IN cord-286132-ag2l1xa7 149 51 a a DT cord-286132-ag2l1xa7 149 52 phase phase NN cord-286132-ag2l1xa7 149 53 2/3 2/3 CD cord-286132-ag2l1xa7 149 54 clinical clinical JJ cord-286132-ag2l1xa7 149 55 trial trial NN cord-286132-ag2l1xa7 149 56 Efficacy Efficacy NNP cord-286132-ag2l1xa7 149 57 and and CC cord-286132-ag2l1xa7 149 58 safety safety NN cord-286132-ag2l1xa7 149 59 of of IN cord-286132-ag2l1xa7 149 60 the the DT cord-286132-ag2l1xa7 149 61 anti anti JJ cord-286132-ag2l1xa7 149 62 - - JJ cord-286132-ag2l1xa7 149 63 IL-12/23 il-12/23 JJ cord-286132-ag2l1xa7 149 64 p40 p40 CD cord-286132-ag2l1xa7 149 65 monoclonal monoclonal JJ cord-286132-ag2l1xa7 149 66 antibody antibody NN cord-286132-ag2l1xa7 149 67 , , , cord-286132-ag2l1xa7 149 68 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 149 69 , , , cord-286132-ag2l1xa7 149 70 in in IN cord-286132-ag2l1xa7 149 71 patients patient NNS cord-286132-ag2l1xa7 149 72 with with IN cord-286132-ag2l1xa7 149 73 active active JJ cord-286132-ag2l1xa7 149 74 psoriatic psoriatic JJ cord-286132-ag2l1xa7 149 75 arthritis arthritis NN cord-286132-ag2l1xa7 149 76 despite despite IN cord-286132-ag2l1xa7 149 77 conventional conventional JJ cord-286132-ag2l1xa7 149 78 non non JJ cord-286132-ag2l1xa7 149 79 - - JJ cord-286132-ag2l1xa7 149 80 biological biological JJ cord-286132-ag2l1xa7 149 81 and and CC cord-286132-ag2l1xa7 149 82 biological biological JJ cord-286132-ag2l1xa7 149 83 anti anti JJ cord-286132-ag2l1xa7 149 84 - - JJ cord-286132-ag2l1xa7 149 85 tumour tumour JJ cord-286132-ag2l1xa7 149 86 necrosis necrosis NN cord-286132-ag2l1xa7 149 87 factor factor NN cord-286132-ag2l1xa7 149 88 therapy therapy NN cord-286132-ag2l1xa7 149 89 : : : cord-286132-ag2l1xa7 149 90 6-month 6-month CD cord-286132-ag2l1xa7 149 91 and and CC cord-286132-ag2l1xa7 149 92 1-year 1-year CD cord-286132-ag2l1xa7 149 93 results result NNS cord-286132-ag2l1xa7 149 94 of of IN cord-286132-ag2l1xa7 149 95 the the DT cord-286132-ag2l1xa7 149 96 phase phase NN cord-286132-ag2l1xa7 149 97 3 3 CD cord-286132-ag2l1xa7 149 98 , , , cord-286132-ag2l1xa7 149 99 multicentre multicentre NNP cord-286132-ag2l1xa7 149 100 , , , cord-286132-ag2l1xa7 149 101 double double JJ cord-286132-ag2l1xa7 149 102 - - HYPH cord-286132-ag2l1xa7 149 103 blind blind JJ cord-286132-ag2l1xa7 149 104 , , , cord-286132-ag2l1xa7 149 105 placebo placebo NN cord-286132-ag2l1xa7 149 106 - - HYPH cord-286132-ag2l1xa7 149 107 controlled control VBN cord-286132-ag2l1xa7 149 108 , , , cord-286132-ag2l1xa7 149 109 randomised randomised JJ cord-286132-ag2l1xa7 149 110 PSUMMIT PSUMMIT NNP cord-286132-ag2l1xa7 149 111 2 2 CD cord-286132-ag2l1xa7 149 112 trial trial NN cord-286132-ag2l1xa7 149 113 Safety safety NN cord-286132-ag2l1xa7 149 114 and and CC cord-286132-ag2l1xa7 149 115 efficacy efficacy NN cord-286132-ag2l1xa7 149 116 of of IN cord-286132-ag2l1xa7 149 117 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 149 118 or or CC cord-286132-ag2l1xa7 149 119 golimumab golimumab NNP cord-286132-ag2l1xa7 149 120 in in IN cord-286132-ag2l1xa7 149 121 patients patient NNS cord-286132-ag2l1xa7 149 122 with with IN cord-286132-ag2l1xa7 149 123 chronic chronic JJ cord-286132-ag2l1xa7 149 124 sarcoidosis sarcoidosis NN cord-286132-ag2l1xa7 149 125 Risankizumab Risankizumab NNP cord-286132-ag2l1xa7 149 126 , , , cord-286132-ag2l1xa7 149 127 an an DT cord-286132-ag2l1xa7 149 128 IL-23 IL-23 NNP cord-286132-ag2l1xa7 149 129 inhibitor inhibitor NN cord-286132-ag2l1xa7 149 130 , , , cord-286132-ag2l1xa7 149 131 for for IN cord-286132-ag2l1xa7 149 132 ankylosing ankylosing NN cord-286132-ag2l1xa7 149 133 spondylitis spondylitis NN cord-286132-ag2l1xa7 149 134 : : : cord-286132-ag2l1xa7 149 135 results result NNS cord-286132-ag2l1xa7 149 136 of of IN cord-286132-ag2l1xa7 149 137 a a DT cord-286132-ag2l1xa7 149 138 randomised randomised JJ cord-286132-ag2l1xa7 149 139 , , , cord-286132-ag2l1xa7 149 140 double double JJ cord-286132-ag2l1xa7 149 141 - - HYPH cord-286132-ag2l1xa7 149 142 blind blind JJ cord-286132-ag2l1xa7 149 143 , , , cord-286132-ag2l1xa7 149 144 placebo placebo NN cord-286132-ag2l1xa7 149 145 - - HYPH cord-286132-ag2l1xa7 149 146 controlled control VBN cord-286132-ag2l1xa7 149 147 , , , cord-286132-ag2l1xa7 149 148 proof proof NN cord-286132-ag2l1xa7 149 149 - - HYPH cord-286132-ag2l1xa7 149 150 of of IN cord-286132-ag2l1xa7 149 151 - - HYPH cord-286132-ag2l1xa7 149 152 concept concept NN cord-286132-ag2l1xa7 149 153 , , , cord-286132-ag2l1xa7 149 154 dose dose NN cord-286132-ag2l1xa7 149 155 - - HYPH cord-286132-ag2l1xa7 149 156 finding find VBG cord-286132-ag2l1xa7 149 157 phase phase NN cord-286132-ag2l1xa7 149 158 2 2 CD cord-286132-ag2l1xa7 149 159 study study NN cord-286132-ag2l1xa7 149 160 Vaccination vaccination NN cord-286132-ag2l1xa7 149 161 recommendations recommendation NNS cord-286132-ag2l1xa7 149 162 for for IN cord-286132-ag2l1xa7 149 163 the the DT cord-286132-ag2l1xa7 149 164 adult adult NN cord-286132-ag2l1xa7 149 165 immunosuppressed immunosuppressed JJ cord-286132-ag2l1xa7 149 166 patient patient NN cord-286132-ag2l1xa7 149 167 : : : cord-286132-ag2l1xa7 149 168 A a DT cord-286132-ag2l1xa7 149 169 systematic systematic JJ cord-286132-ag2l1xa7 149 170 review review NN cord-286132-ag2l1xa7 149 171 and and CC cord-286132-ag2l1xa7 149 172 comprehensive comprehensive JJ cord-286132-ag2l1xa7 149 173 field field NN cord-286132-ag2l1xa7 149 174 synopsis synopsis NN cord-286132-ag2l1xa7 149 175 Interstitial Interstitial NNP cord-286132-ag2l1xa7 149 176 Pneumonia Pneumonia NNP cord-286132-ag2l1xa7 149 177 in in IN cord-286132-ag2l1xa7 149 178 Psoriasis Psoriasis NNP cord-286132-ag2l1xa7 149 179 Management Management NNP cord-286132-ag2l1xa7 149 180 of of IN cord-286132-ag2l1xa7 149 181 interstitial interstitial JJ cord-286132-ag2l1xa7 149 182 lung lung NN cord-286132-ag2l1xa7 149 183 disease disease NN cord-286132-ag2l1xa7 149 184 associated associate VBN cord-286132-ag2l1xa7 149 185 with with IN cord-286132-ag2l1xa7 149 186 connective connective JJ cord-286132-ag2l1xa7 149 187 tissue tissue NN cord-286132-ag2l1xa7 149 188 disease disease NN cord-286132-ag2l1xa7 149 189 Thoracic thoracic JJ cord-286132-ag2l1xa7 149 190 manifestations manifestation NNS cord-286132-ag2l1xa7 149 191 of of IN cord-286132-ag2l1xa7 149 192 inflammatory inflammatory JJ cord-286132-ag2l1xa7 149 193 bowel bowel NN cord-286132-ag2l1xa7 149 194 disease disease NN cord-286132-ag2l1xa7 150 1 Distinct distinct JJ cord-286132-ag2l1xa7 150 2 immune immune JJ cord-286132-ag2l1xa7 150 3 response response NN cord-286132-ag2l1xa7 150 4 in in IN cord-286132-ag2l1xa7 150 5 two two CD cord-286132-ag2l1xa7 150 6 MERS MERS NNP cord-286132-ag2l1xa7 150 7 - - HYPH cord-286132-ag2l1xa7 150 8 CoV cov NN cord-286132-ag2l1xa7 150 9 - - HYPH cord-286132-ag2l1xa7 150 10 infected infect VBN cord-286132-ag2l1xa7 150 11 patients patient NNS cord-286132-ag2l1xa7 150 12 : : : cord-286132-ag2l1xa7 150 13 can can MD cord-286132-ag2l1xa7 150 14 we -PRON- PRP cord-286132-ag2l1xa7 150 15 go go VB cord-286132-ag2l1xa7 150 16 from from IN cord-286132-ag2l1xa7 150 17 bench bench NN cord-286132-ag2l1xa7 150 18 to to IN cord-286132-ag2l1xa7 150 19 bedside bedside NN cord-286132-ag2l1xa7 150 20 ? ? . cord-286132-ag2l1xa7 151 1 Immunology Immunology NNP cord-286132-ag2l1xa7 151 2 taught teach VBD cord-286132-ag2l1xa7 151 3 by by IN cord-286132-ag2l1xa7 151 4 human human JJ cord-286132-ag2l1xa7 151 5 genetics genetic NNS cord-286132-ag2l1xa7 151 6 IL-23 IL-23 NNP cord-286132-ag2l1xa7 151 7 is be VBZ cord-286132-ag2l1xa7 151 8 essential essential JJ cord-286132-ag2l1xa7 151 9 for for IN cord-286132-ag2l1xa7 151 10 T T NNP cord-286132-ag2l1xa7 151 11 cell cell NN cord-286132-ag2l1xa7 151 12 - - HYPH cord-286132-ag2l1xa7 151 13 mediated mediate VBN cord-286132-ag2l1xa7 151 14 colitis colitis NN cord-286132-ag2l1xa7 151 15 and and CC cord-286132-ag2l1xa7 151 16 promotes promote VBZ cord-286132-ag2l1xa7 151 17 inflammation inflammation NN cord-286132-ag2l1xa7 151 18 via via IN cord-286132-ag2l1xa7 151 19 IL-17 IL-17 NNP cord-286132-ag2l1xa7 151 20 and and CC cord-286132-ag2l1xa7 151 21 IL-6 IL-6 NNP cord-286132-ag2l1xa7 151 22 IL-12 IL-12 NNP cord-286132-ag2l1xa7 151 23 and and CC cord-286132-ag2l1xa7 151 24 IL-23 IL-23 NNP cord-286132-ag2l1xa7 151 25 cytokines cytokine NNS cord-286132-ag2l1xa7 151 26 : : : cord-286132-ag2l1xa7 151 27 from from IN cord-286132-ag2l1xa7 151 28 discovery discovery NN cord-286132-ag2l1xa7 151 29 to to IN cord-286132-ag2l1xa7 151 30 targeted target VBN cord-286132-ag2l1xa7 151 31 therapies therapy NNS cord-286132-ag2l1xa7 151 32 for for IN cord-286132-ag2l1xa7 151 33 immune immune NN cord-286132-ag2l1xa7 151 34 - - HYPH cord-286132-ag2l1xa7 151 35 mediated mediate VBN cord-286132-ag2l1xa7 151 36 inflammatory inflammatory JJ cord-286132-ag2l1xa7 151 37 diseases disease NNS cord-286132-ag2l1xa7 151 38 Critical critical JJ cord-286132-ag2l1xa7 151 39 role role NN cord-286132-ag2l1xa7 151 40 of of IN cord-286132-ag2l1xa7 151 41 IL-17RA il-17ra NN cord-286132-ag2l1xa7 151 42 in in IN cord-286132-ag2l1xa7 151 43 immunopathology immunopathology NN cord-286132-ag2l1xa7 151 44 of of IN cord-286132-ag2l1xa7 151 45 influenza influenza NN cord-286132-ag2l1xa7 151 46 infection infection NN cord-286132-ag2l1xa7 151 47 What what WP cord-286132-ag2l1xa7 151 48 to to TO cord-286132-ag2l1xa7 151 49 add add VB cord-286132-ag2l1xa7 151 50 to to IN cord-286132-ag2l1xa7 151 51 nothing nothing NN cord-286132-ag2l1xa7 151 52 ? ? . cord-286132-ag2l1xa7 152 1 Use use VB cord-286132-ag2l1xa7 152 2 and and CC cord-286132-ag2l1xa7 152 3 avoidance avoidance NN cord-286132-ag2l1xa7 152 4 of of IN cord-286132-ag2l1xa7 152 5 continuity continuity NN cord-286132-ag2l1xa7 152 6 corrections correction NNS cord-286132-ag2l1xa7 152 7 in in IN cord-286132-ag2l1xa7 152 8 meta meta NNP cord-286132-ag2l1xa7 152 9 - - HYPH cord-286132-ag2l1xa7 152 10 analysis analysis NN cord-286132-ag2l1xa7 152 11 of of IN cord-286132-ag2l1xa7 152 12 sparse sparse JJ cord-286132-ag2l1xa7 152 13 data datum NNS cord-286132-ag2l1xa7 152 14 an an DT cord-286132-ag2l1xa7 152 15 anti anti JJ cord-286132-ag2l1xa7 152 16 - - JJ cord-286132-ag2l1xa7 152 17 interleukin-23 interleukin-23 JJ cord-286132-ag2l1xa7 152 18 monoclonal monoclonal JJ cord-286132-ag2l1xa7 152 19 antibody antibody NN cord-286132-ag2l1xa7 152 20 , , , cord-286132-ag2l1xa7 152 21 for for IN cord-286132-ag2l1xa7 152 22 the the DT cord-286132-ag2l1xa7 152 23 treatment treatment NN cord-286132-ag2l1xa7 152 24 of of IN cord-286132-ag2l1xa7 152 25 moderate moderate JJ cord-286132-ag2l1xa7 152 26 to to IN cord-286132-ag2l1xa7 152 27 severe severe JJ cord-286132-ag2l1xa7 152 28 plaque plaque NN cord-286132-ag2l1xa7 152 29 - - HYPH cord-286132-ag2l1xa7 152 30 type type NN cord-286132-ag2l1xa7 152 31 psoriasis psoriasis NN cord-286132-ag2l1xa7 152 32 in in IN cord-286132-ag2l1xa7 152 33 Japanese japanese JJ cord-286132-ag2l1xa7 152 34 patients patient NNS cord-286132-ag2l1xa7 152 35 : : : cord-286132-ag2l1xa7 153 1 Efficacy efficacy NN cord-286132-ag2l1xa7 153 2 and and CC cord-286132-ag2l1xa7 153 3 safety safety NN cord-286132-ag2l1xa7 153 4 results result NNS cord-286132-ag2l1xa7 153 5 from from IN cord-286132-ag2l1xa7 153 6 a a DT cord-286132-ag2l1xa7 153 7 phase phase NN cord-286132-ag2l1xa7 153 8 3 3 CD cord-286132-ag2l1xa7 153 9 , , , cord-286132-ag2l1xa7 153 10 randomized randomized JJ cord-286132-ag2l1xa7 153 11 , , , cord-286132-ag2l1xa7 153 12 double double JJ cord-286132-ag2l1xa7 153 13 - - HYPH cord-286132-ag2l1xa7 153 14 blind blind JJ cord-286132-ag2l1xa7 153 15 , , , cord-286132-ag2l1xa7 153 16 placebo placebo NN cord-286132-ag2l1xa7 153 17 - - HYPH cord-286132-ag2l1xa7 153 18 controlled control VBN cord-286132-ag2l1xa7 153 19 study study NN cord-286132-ag2l1xa7 153 20 Safety safety NN cord-286132-ag2l1xa7 153 21 and and CC cord-286132-ag2l1xa7 153 22 efficacy efficacy NN cord-286132-ag2l1xa7 153 23 of of IN cord-286132-ag2l1xa7 153 24 guselkumab guselkumab NNS cord-286132-ag2l1xa7 153 25 in in IN cord-286132-ag2l1xa7 153 26 Japanese japanese JJ cord-286132-ag2l1xa7 153 27 patients patient NNS cord-286132-ag2l1xa7 153 28 with with IN cord-286132-ag2l1xa7 153 29 moderate moderate JJ cord-286132-ag2l1xa7 153 30 - - HYPH cord-286132-ag2l1xa7 153 31 to to IN cord-286132-ag2l1xa7 153 32 - - HYPH cord-286132-ag2l1xa7 153 33 severe severe JJ cord-286132-ag2l1xa7 153 34 plaque plaque NN cord-286132-ag2l1xa7 153 35 psoriasis psoriasis NN cord-286132-ag2l1xa7 153 36 : : : cord-286132-ag2l1xa7 153 37 a a DT cord-286132-ag2l1xa7 153 38 randomized randomized JJ cord-286132-ag2l1xa7 153 39 , , , cord-286132-ag2l1xa7 153 40 placebo placebo NN cord-286132-ag2l1xa7 153 41 - - HYPH cord-286132-ag2l1xa7 153 42 controlled control VBN cord-286132-ag2l1xa7 153 43 , , , cord-286132-ag2l1xa7 153 44 ascending ascend VBG cord-286132-ag2l1xa7 153 45 - - HYPH cord-286132-ag2l1xa7 153 46 dose dose NN cord-286132-ag2l1xa7 153 47 study study NN cord-286132-ag2l1xa7 153 48 Efficacy Efficacy NNP cord-286132-ag2l1xa7 153 49 and and CC cord-286132-ag2l1xa7 153 50 safety safety NN cord-286132-ag2l1xa7 153 51 of of IN cord-286132-ag2l1xa7 153 52 guselkumab guselkumab NNS cord-286132-ag2l1xa7 153 53 , , , cord-286132-ag2l1xa7 153 54 an an DT cord-286132-ag2l1xa7 153 55 anti anti JJ cord-286132-ag2l1xa7 153 56 - - JJ cord-286132-ag2l1xa7 153 57 interleukin-23 interleukin-23 JJ cord-286132-ag2l1xa7 153 58 monoclonal monoclonal JJ cord-286132-ag2l1xa7 153 59 antibody antibody NN cord-286132-ag2l1xa7 153 60 , , , cord-286132-ag2l1xa7 153 61 compared compare VBN cord-286132-ag2l1xa7 153 62 with with IN cord-286132-ag2l1xa7 153 63 adalimumab adalimumab NNS cord-286132-ag2l1xa7 153 64 for for IN cord-286132-ag2l1xa7 153 65 the the DT cord-286132-ag2l1xa7 153 66 continuous continuous JJ cord-286132-ag2l1xa7 153 67 treatment treatment NN cord-286132-ag2l1xa7 153 68 of of IN cord-286132-ag2l1xa7 153 69 patients patient NNS cord-286132-ag2l1xa7 153 70 with with IN cord-286132-ag2l1xa7 153 71 moderate moderate JJ cord-286132-ag2l1xa7 153 72 to to IN cord-286132-ag2l1xa7 153 73 severe severe JJ cord-286132-ag2l1xa7 153 74 psoriasis psoriasis NN cord-286132-ag2l1xa7 154 1 : : : cord-286132-ag2l1xa7 154 2 Results result NNS cord-286132-ag2l1xa7 154 3 from from IN cord-286132-ag2l1xa7 154 4 the the DT cord-286132-ag2l1xa7 154 5 phase phase NN cord-286132-ag2l1xa7 154 6 III iii CD cord-286132-ag2l1xa7 154 7 , , , cord-286132-ag2l1xa7 154 8 double double RB cord-286132-ag2l1xa7 154 9 - - HYPH cord-286132-ag2l1xa7 154 10 blinded blinded JJ cord-286132-ag2l1xa7 154 11 , , , cord-286132-ag2l1xa7 154 12 placebo placebo NN cord-286132-ag2l1xa7 154 13 - - HYPH cord-286132-ag2l1xa7 154 14 and and CC cord-286132-ag2l1xa7 154 15 active active JJ cord-286132-ag2l1xa7 154 16 comparator comparator NN cord-286132-ag2l1xa7 154 17 - - HYPH cord-286132-ag2l1xa7 154 18 controlled control VBN cord-286132-ag2l1xa7 154 19 VOYAGE voyage NN cord-286132-ag2l1xa7 154 20 1 1 CD cord-286132-ag2l1xa7 154 21 trial trial NN cord-286132-ag2l1xa7 154 22 Guselkumab Guselkumab NNP cord-286132-ag2l1xa7 154 23 ( ( -LRB- cord-286132-ag2l1xa7 154 24 an an DT cord-286132-ag2l1xa7 154 25 IL-23-specific IL-23-specific NNP cord-286132-ag2l1xa7 154 26 mAb mab NN cord-286132-ag2l1xa7 154 27 ) ) -RRB- cord-286132-ag2l1xa7 154 28 demonstrates demonstrate VBZ cord-286132-ag2l1xa7 154 29 clinical clinical JJ cord-286132-ag2l1xa7 154 30 and and CC cord-286132-ag2l1xa7 154 31 molecular molecular JJ cord-286132-ag2l1xa7 154 32 response response NN cord-286132-ag2l1xa7 154 33 in in IN cord-286132-ag2l1xa7 154 34 patients patient NNS cord-286132-ag2l1xa7 154 35 with with IN cord-286132-ag2l1xa7 154 36 moderate moderate JJ cord-286132-ag2l1xa7 154 37 - - HYPH cord-286132-ag2l1xa7 154 38 to to IN cord-286132-ag2l1xa7 154 39 - - HYPH cord-286132-ag2l1xa7 154 40 severe severe JJ cord-286132-ag2l1xa7 154 41 psoriasis psoriasis NN cord-286132-ag2l1xa7 154 42 Efficacy Efficacy NNP cord-286132-ag2l1xa7 154 43 and and CC cord-286132-ag2l1xa7 154 44 Safety Safety NNP cord-286132-ag2l1xa7 154 45 of of IN cord-286132-ag2l1xa7 154 46 Guselkumab Guselkumab NNP cord-286132-ag2l1xa7 154 47 , , , cord-286132-ag2l1xa7 154 48 an an DT cord-286132-ag2l1xa7 154 49 Anti anti JJ cord-286132-ag2l1xa7 154 50 - - JJ cord-286132-ag2l1xa7 154 51 interleukin interleukin JJ cord-286132-ag2l1xa7 154 52 23 23 CD cord-286132-ag2l1xa7 154 53 Monoclonal Monoclonal NNP cord-286132-ag2l1xa7 154 54 Antibody Antibody NNP cord-286132-ag2l1xa7 154 55 , , , cord-286132-ag2l1xa7 154 56 for for IN cord-286132-ag2l1xa7 154 57 Palmoplantar Palmoplantar NNP cord-286132-ag2l1xa7 154 58 Pustulosis Pustulosis NNP cord-286132-ag2l1xa7 154 59 : : : cord-286132-ag2l1xa7 155 1 A a DT cord-286132-ag2l1xa7 155 2 Randomized Randomized NNP cord-286132-ag2l1xa7 155 3 Clinical Clinical NNP cord-286132-ag2l1xa7 155 4 Trial Trial NNP cord-286132-ag2l1xa7 155 5 First first JJ cord-286132-ag2l1xa7 155 6 - - HYPH cord-286132-ag2l1xa7 155 7 in in IN cord-286132-ag2l1xa7 155 8 - - HYPH cord-286132-ag2l1xa7 155 9 human human JJ cord-286132-ag2l1xa7 155 10 study study NN cord-286132-ag2l1xa7 155 11 to to TO cord-286132-ag2l1xa7 155 12 assess assess VB cord-286132-ag2l1xa7 155 13 guselkumab guselkumab NNS cord-286132-ag2l1xa7 155 14 ( ( -LRB- cord-286132-ag2l1xa7 155 15 anti anti JJ cord-286132-ag2l1xa7 155 16 - - JJ cord-286132-ag2l1xa7 155 17 IL-23 IL-23 NNP cord-286132-ag2l1xa7 155 18 mAb mAb NNP cord-286132-ag2l1xa7 155 19 ) ) -RRB- cord-286132-ag2l1xa7 155 20 pharmacokinetics pharmacokinetic NNS cord-286132-ag2l1xa7 155 21 / / SYM cord-286132-ag2l1xa7 155 22 safety safety NN cord-286132-ag2l1xa7 155 23 in in IN cord-286132-ag2l1xa7 155 24 healthy healthy JJ cord-286132-ag2l1xa7 155 25 subjects subject NNS cord-286132-ag2l1xa7 155 26 and and CC cord-286132-ag2l1xa7 155 27 patients patient NNS cord-286132-ag2l1xa7 155 28 with with IN cord-286132-ag2l1xa7 155 29 moderate moderate JJ cord-286132-ag2l1xa7 155 30 - - HYPH cord-286132-ag2l1xa7 155 31 to to IN cord-286132-ag2l1xa7 155 32 - - HYPH cord-286132-ag2l1xa7 155 33 severe severe JJ cord-286132-ag2l1xa7 155 34 psoriasis psoriasis NN cord-286132-ag2l1xa7 155 35 Anti anti NN cord-286132-ag2l1xa7 155 36 - - NNP cord-286132-ag2l1xa7 155 37 IL-23A IL-23A NNP cord-286132-ag2l1xa7 155 38 mAb mAb HYPH cord-286132-ag2l1xa7 155 39 BI BI NNP cord-286132-ag2l1xa7 155 40 655066 655066 CD cord-286132-ag2l1xa7 155 41 for for IN cord-286132-ag2l1xa7 155 42 treatment treatment NN cord-286132-ag2l1xa7 155 43 of of IN cord-286132-ag2l1xa7 155 44 moderate moderate JJ cord-286132-ag2l1xa7 155 45 - - HYPH cord-286132-ag2l1xa7 155 46 to to IN cord-286132-ag2l1xa7 155 47 - - HYPH cord-286132-ag2l1xa7 155 48 severe severe JJ cord-286132-ag2l1xa7 155 49 psoriasis psoriasis NN cord-286132-ag2l1xa7 155 50 : : : cord-286132-ag2l1xa7 155 51 Safety safety NN cord-286132-ag2l1xa7 155 52 , , , cord-286132-ag2l1xa7 155 53 efficacy efficacy NN cord-286132-ag2l1xa7 155 54 , , , cord-286132-ag2l1xa7 155 55 pharmacokinetics pharmacokinetic NNS cord-286132-ag2l1xa7 155 56 , , , cord-286132-ag2l1xa7 155 57 and and CC cord-286132-ag2l1xa7 155 58 biomarker biomarker NN cord-286132-ag2l1xa7 155 59 results result NNS cord-286132-ag2l1xa7 155 60 of of IN cord-286132-ag2l1xa7 155 61 a a DT cord-286132-ag2l1xa7 155 62 single single RB cord-286132-ag2l1xa7 155 63 - - HYPH cord-286132-ag2l1xa7 155 64 rising rise VBG cord-286132-ag2l1xa7 155 65 - - HYPH cord-286132-ag2l1xa7 155 66 dose dose NN cord-286132-ag2l1xa7 155 67 , , , cord-286132-ag2l1xa7 155 68 randomized randomized JJ cord-286132-ag2l1xa7 155 69 , , , cord-286132-ag2l1xa7 155 70 double double JJ cord-286132-ag2l1xa7 155 71 - - HYPH cord-286132-ag2l1xa7 155 72 blind blind JJ cord-286132-ag2l1xa7 155 73 , , , cord-286132-ag2l1xa7 155 74 placebo placebo NN cord-286132-ag2l1xa7 155 75 - - HYPH cord-286132-ag2l1xa7 155 76 controlled control VBN cord-286132-ag2l1xa7 155 77 trial trial NN cord-286132-ag2l1xa7 155 78 Pharmacokinetics Pharmacokinetics NNP cord-286132-ag2l1xa7 155 79 of of IN cord-286132-ag2l1xa7 155 80 Tildrakizumab Tildrakizumab NNP cord-286132-ag2l1xa7 155 81 ( ( -LRB- cord-286132-ag2l1xa7 155 82 MK-3222 MK-3222 NNP cord-286132-ag2l1xa7 155 83 ) ) -RRB- cord-286132-ag2l1xa7 155 84 , , , cord-286132-ag2l1xa7 155 85 an an DT cord-286132-ag2l1xa7 155 86 Anti Anti NNP cord-286132-ag2l1xa7 155 87 - - NNP cord-286132-ag2l1xa7 155 88 IL-23 IL-23 NNP cord-286132-ag2l1xa7 155 89 Monoclonal Monoclonal NNP cord-286132-ag2l1xa7 155 90 After after IN cord-286132-ag2l1xa7 155 91 Intravenous Intravenous NNP cord-286132-ag2l1xa7 155 92 or or CC cord-286132-ag2l1xa7 155 93 Subcutaneous Subcutaneous NNP cord-286132-ag2l1xa7 155 94 Administration Administration NNP cord-286132-ag2l1xa7 155 95 in in IN cord-286132-ag2l1xa7 155 96 Healthy Healthy NNP cord-286132-ag2l1xa7 155 97 Subjects Subjects NNPS cord-286132-ag2l1xa7 155 98 Efficacy Efficacy NNP cord-286132-ag2l1xa7 155 99 and and CC cord-286132-ag2l1xa7 155 100 safety safety NN cord-286132-ag2l1xa7 155 101 of of IN cord-286132-ag2l1xa7 155 102 briakinumab briakinumab NNP cord-286132-ag2l1xa7 155 103 vs. vs. FW cord-286132-ag2l1xa7 155 104 etanercept etanercept NNP cord-286132-ag2l1xa7 155 105 and and CC cord-286132-ag2l1xa7 155 106 placebo placebo NN cord-286132-ag2l1xa7 155 107 in in IN cord-286132-ag2l1xa7 155 108 patients patient NNS cord-286132-ag2l1xa7 155 109 with with IN cord-286132-ag2l1xa7 155 110 moderate moderate JJ cord-286132-ag2l1xa7 155 111 to to IN cord-286132-ag2l1xa7 155 112 severe severe JJ cord-286132-ag2l1xa7 155 113 chronic chronic JJ cord-286132-ag2l1xa7 155 114 plaque plaque NN cord-286132-ag2l1xa7 155 115 psoriasis psoriasis NN cord-286132-ag2l1xa7 155 116 Efficacy Efficacy NNP cord-286132-ag2l1xa7 155 117 and and CC cord-286132-ag2l1xa7 155 118 safety safety NN cord-286132-ag2l1xa7 155 119 results result NNS cord-286132-ag2l1xa7 155 120 from from IN cord-286132-ag2l1xa7 155 121 a a DT cord-286132-ag2l1xa7 155 122 phase phase NN cord-286132-ag2l1xa7 155 123 III iii CD cord-286132-ag2l1xa7 155 124 , , , cord-286132-ag2l1xa7 155 125 randomized randomize VBN cord-286132-ag2l1xa7 155 126 controlled control VBN cord-286132-ag2l1xa7 155 127 trial trial NN cord-286132-ag2l1xa7 155 128 comparing compare VBG cord-286132-ag2l1xa7 155 129 the the DT cord-286132-ag2l1xa7 155 130 safety safety NN cord-286132-ag2l1xa7 155 131 and and CC cord-286132-ag2l1xa7 155 132 efficacy efficacy NN cord-286132-ag2l1xa7 155 133 of of IN cord-286132-ag2l1xa7 155 134 briakinumab briakinumab NNP cord-286132-ag2l1xa7 155 135 with with IN cord-286132-ag2l1xa7 155 136 etanercept etanercept NNP cord-286132-ag2l1xa7 155 137 and and CC cord-286132-ag2l1xa7 155 138 placebo placebo NN cord-286132-ag2l1xa7 155 139 in in IN cord-286132-ag2l1xa7 155 140 patients patient NNS cord-286132-ag2l1xa7 155 141 with with IN cord-286132-ag2l1xa7 155 142 moderate moderate JJ cord-286132-ag2l1xa7 155 143 to to IN cord-286132-ag2l1xa7 155 144 severe severe JJ cord-286132-ag2l1xa7 155 145 chronic chronic JJ cord-286132-ag2l1xa7 155 146 plaque plaque NN cord-286132-ag2l1xa7 155 147 psoriasis psoriasis NN cord-286132-ag2l1xa7 155 148 Safety safety NN cord-286132-ag2l1xa7 155 149 and and CC cord-286132-ag2l1xa7 155 150 efficacy efficacy NN cord-286132-ag2l1xa7 155 151 of of IN cord-286132-ag2l1xa7 155 152 ABT-874 abt-874 DT cord-286132-ag2l1xa7 155 153 monoclonal monoclonal JJ cord-286132-ag2l1xa7 155 154 antibody antibody NN cord-286132-ag2l1xa7 155 155 , , , cord-286132-ag2l1xa7 155 156 in in IN cord-286132-ag2l1xa7 155 157 the the DT cord-286132-ag2l1xa7 155 158 treatment treatment NN cord-286132-ag2l1xa7 155 159 of of IN cord-286132-ag2l1xa7 155 160 moderate moderate JJ cord-286132-ag2l1xa7 155 161 to to IN cord-286132-ag2l1xa7 155 162 severe severe JJ cord-286132-ag2l1xa7 155 163 chronic chronic JJ cord-286132-ag2l1xa7 155 164 plaque plaque NN cord-286132-ag2l1xa7 155 165 psoriasis psoriasis NN cord-286132-ag2l1xa7 155 166 : : : cord-286132-ag2l1xa7 155 167 results result NNS cord-286132-ag2l1xa7 155 168 of of IN cord-286132-ag2l1xa7 155 169 a a DT cord-286132-ag2l1xa7 155 170 randomized randomized JJ cord-286132-ag2l1xa7 155 171 , , , cord-286132-ag2l1xa7 155 172 placebo placebo NN cord-286132-ag2l1xa7 155 173 - - HYPH cord-286132-ag2l1xa7 155 174 controlled control VBN cord-286132-ag2l1xa7 155 175 , , , cord-286132-ag2l1xa7 155 176 phase phase NN cord-286132-ag2l1xa7 155 177 2 2 CD cord-286132-ag2l1xa7 155 178 trial trial NN cord-286132-ag2l1xa7 155 179 Anti Anti NNP cord-286132-ag2l1xa7 155 180 - - JJ cord-286132-ag2l1xa7 155 181 interleukin-12 interleukin-12 JJ cord-286132-ag2l1xa7 155 182 antibody antibody NN cord-286132-ag2l1xa7 155 183 for for IN cord-286132-ag2l1xa7 155 184 active active JJ cord-286132-ag2l1xa7 155 185 Crohn Crohn NNP cord-286132-ag2l1xa7 155 186 's 's POS cord-286132-ag2l1xa7 155 187 disease disease NN cord-286132-ag2l1xa7 155 188 A a DT cord-286132-ag2l1xa7 155 189 phase phase NN cord-286132-ag2l1xa7 155 190 2 2 CD cord-286132-ag2l1xa7 155 191 , , , cord-286132-ag2l1xa7 155 192 24-week 24-week JJ cord-286132-ag2l1xa7 155 193 , , , cord-286132-ag2l1xa7 155 194 randomized randomized JJ cord-286132-ag2l1xa7 155 195 , , , cord-286132-ag2l1xa7 155 196 placebo placebo NN cord-286132-ag2l1xa7 155 197 - - HYPH cord-286132-ag2l1xa7 155 198 controlled control VBN cord-286132-ag2l1xa7 155 199 , , , cord-286132-ag2l1xa7 155 200 double double JJ cord-286132-ag2l1xa7 155 201 - - HYPH cord-286132-ag2l1xa7 155 202 blind blind JJ cord-286132-ag2l1xa7 155 203 study study NN cord-286132-ag2l1xa7 155 204 examining examine VBG cord-286132-ag2l1xa7 155 205 the the DT cord-286132-ag2l1xa7 155 206 efficacy efficacy NN cord-286132-ag2l1xa7 155 207 and and CC cord-286132-ag2l1xa7 155 208 safety safety NN cord-286132-ag2l1xa7 155 209 of of IN cord-286132-ag2l1xa7 155 210 an an DT cord-286132-ag2l1xa7 155 211 anti anti JJ cord-286132-ag2l1xa7 155 212 - - JJ cord-286132-ag2l1xa7 155 213 interleukin-12 interleukin-12 JJ cord-286132-ag2l1xa7 155 214 and and CC cord-286132-ag2l1xa7 155 215 -23 -23 NN cord-286132-ag2l1xa7 155 216 monoclonal monoclonal JJ cord-286132-ag2l1xa7 155 217 antibody antibody NN cord-286132-ag2l1xa7 155 218 in in IN cord-286132-ag2l1xa7 155 219 patients patient NNS cord-286132-ag2l1xa7 155 220 with with IN cord-286132-ag2l1xa7 155 221 relapsing relapse VBG cord-286132-ag2l1xa7 155 222 - - HYPH cord-286132-ag2l1xa7 155 223 remitting remit VBG cord-286132-ag2l1xa7 155 224 or or CC cord-286132-ag2l1xa7 155 225 secondary secondary JJ cord-286132-ag2l1xa7 155 226 progressive progressive JJ cord-286132-ag2l1xa7 155 227 multiple multiple JJ cord-286132-ag2l1xa7 155 228 sclerosis sclerosis NN cord-286132-ag2l1xa7 155 229 Ustekinumab Ustekinumab NNP cord-286132-ag2l1xa7 155 230 in in IN cord-286132-ag2l1xa7 155 231 adolescent adolescent JJ cord-286132-ag2l1xa7 155 232 patients patient NNS cord-286132-ag2l1xa7 155 233 age age NN cord-286132-ag2l1xa7 155 234 12 12 CD cord-286132-ag2l1xa7 155 235 to to TO cord-286132-ag2l1xa7 155 236 17 17 CD cord-286132-ag2l1xa7 155 237 years year NNS cord-286132-ag2l1xa7 155 238 with with IN cord-286132-ag2l1xa7 155 239 moderate moderate JJ cord-286132-ag2l1xa7 155 240 - - HYPH cord-286132-ag2l1xa7 155 241 to to IN cord-286132-ag2l1xa7 155 242 - - HYPH cord-286132-ag2l1xa7 155 243 severe severe JJ cord-286132-ag2l1xa7 155 244 plaque plaque NN cord-286132-ag2l1xa7 155 245 psoriasis psoriasis NN cord-286132-ag2l1xa7 155 246 : : : cord-286132-ag2l1xa7 155 247 results result NNS cord-286132-ag2l1xa7 155 248 of of IN cord-286132-ag2l1xa7 155 249 the the DT cord-286132-ag2l1xa7 155 250 randomized randomized JJ cord-286132-ag2l1xa7 155 251 phase phase NN cord-286132-ag2l1xa7 155 252 3 3 CD cord-286132-ag2l1xa7 155 253 CADMUS CADMUS NNP cord-286132-ag2l1xa7 155 254 study study NN cord-286132-ag2l1xa7 155 255 Phase Phase NNP cord-286132-ag2l1xa7 156 1 3 3 LS cord-286132-ag2l1xa7 156 2 Studies study NNS cord-286132-ag2l1xa7 156 3 Comparing compare VBG cord-286132-ag2l1xa7 156 4 Brodalumab Brodalumab NNP cord-286132-ag2l1xa7 156 5 with with IN cord-286132-ag2l1xa7 156 6 Ustekinumab Ustekinumab NNP cord-286132-ag2l1xa7 156 7 in in IN cord-286132-ag2l1xa7 156 8 Psoriasis Psoriasis NNP cord-286132-ag2l1xa7 156 9 Efficacy Efficacy NNP cord-286132-ag2l1xa7 156 10 and and CC cord-286132-ag2l1xa7 156 11 safety safety NN cord-286132-ag2l1xa7 156 12 of of IN cord-286132-ag2l1xa7 156 13 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 156 14 in in IN cord-286132-ag2l1xa7 156 15 Chinese chinese JJ cord-286132-ag2l1xa7 156 16 patients patient NNS cord-286132-ag2l1xa7 156 17 with with IN cord-286132-ag2l1xa7 156 18 moderate moderate JJ cord-286132-ag2l1xa7 156 19 to to IN cord-286132-ag2l1xa7 156 20 severe severe JJ cord-286132-ag2l1xa7 156 21 plaque plaque NN cord-286132-ag2l1xa7 156 22 - - HYPH cord-286132-ag2l1xa7 156 23 type type NN cord-286132-ag2l1xa7 156 24 psoriasis psoriasis NN cord-286132-ag2l1xa7 156 25 : : : cord-286132-ag2l1xa7 156 26 results result NNS cord-286132-ag2l1xa7 156 27 from from IN cord-286132-ag2l1xa7 156 28 a a DT cord-286132-ag2l1xa7 156 29 phase phase NN cord-286132-ag2l1xa7 156 30 3 3 CD cord-286132-ag2l1xa7 156 31 clinical clinical JJ cord-286132-ag2l1xa7 156 32 trial trial NN cord-286132-ag2l1xa7 156 33 ( ( -LRB- cord-286132-ag2l1xa7 156 34 LOTUS LOTUS NNP cord-286132-ag2l1xa7 156 35 ) ) -RRB- cord-286132-ag2l1xa7 156 36 Efficacy Efficacy NNP cord-286132-ag2l1xa7 156 37 and and CC cord-286132-ag2l1xa7 156 38 safety safety NN cord-286132-ag2l1xa7 156 39 of of IN cord-286132-ag2l1xa7 156 40 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 156 41 for for IN cord-286132-ag2l1xa7 156 42 the the DT cord-286132-ag2l1xa7 156 43 treatment treatment NN cord-286132-ag2l1xa7 156 44 of of IN cord-286132-ag2l1xa7 156 45 moderate moderate JJ cord-286132-ag2l1xa7 156 46 - - HYPH cord-286132-ag2l1xa7 156 47 to to IN cord-286132-ag2l1xa7 156 48 - - HYPH cord-286132-ag2l1xa7 156 49 severe severe JJ cord-286132-ag2l1xa7 156 50 psoriasis psoriasis NN cord-286132-ag2l1xa7 156 51 : : : cord-286132-ag2l1xa7 156 52 a a DT cord-286132-ag2l1xa7 156 53 phase phase NN cord-286132-ag2l1xa7 156 54 III iii CD cord-286132-ag2l1xa7 156 55 , , , cord-286132-ag2l1xa7 156 56 randomized randomized JJ cord-286132-ag2l1xa7 156 57 , , , cord-286132-ag2l1xa7 156 58 placebo placebo NN cord-286132-ag2l1xa7 156 59 - - HYPH cord-286132-ag2l1xa7 156 60 controlled control VBN cord-286132-ag2l1xa7 156 61 trial trial NN cord-286132-ag2l1xa7 156 62 in in IN cord-286132-ag2l1xa7 156 63 Taiwanese taiwanese JJ cord-286132-ag2l1xa7 156 64 and and CC cord-286132-ag2l1xa7 156 65 Korean korean JJ cord-286132-ag2l1xa7 156 66 patients patient NNS cord-286132-ag2l1xa7 156 67 ( ( -LRB- cord-286132-ag2l1xa7 156 68 PEARL PEARL NNP cord-286132-ag2l1xa7 156 69 ) ) -RRB- cord-286132-ag2l1xa7 156 70 Efficacy efficacy NN cord-286132-ag2l1xa7 156 71 and and CC cord-286132-ag2l1xa7 156 72 safety safety NN cord-286132-ag2l1xa7 156 73 of of IN cord-286132-ag2l1xa7 156 74 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 156 75 , , , cord-286132-ag2l1xa7 156 76 a a DT cord-286132-ag2l1xa7 156 77 human human JJ cord-286132-ag2l1xa7 156 78 interleukin-12/23 interleukin-12/23 NNP cord-286132-ag2l1xa7 156 79 monoclonal monoclonal JJ cord-286132-ag2l1xa7 156 80 antibody antibody NN cord-286132-ag2l1xa7 156 81 , , , cord-286132-ag2l1xa7 156 82 in in IN cord-286132-ag2l1xa7 156 83 patients patient NNS cord-286132-ag2l1xa7 156 84 with with IN cord-286132-ag2l1xa7 156 85 psoriasis psoriasis NN cord-286132-ag2l1xa7 156 86 : : : cord-286132-ag2l1xa7 156 87 76-week 76-week CD cord-286132-ag2l1xa7 156 88 results result NNS cord-286132-ag2l1xa7 156 89 from from IN cord-286132-ag2l1xa7 156 90 a a DT cord-286132-ag2l1xa7 156 91 randomised randomised JJ cord-286132-ag2l1xa7 156 92 , , , cord-286132-ag2l1xa7 156 93 double double JJ cord-286132-ag2l1xa7 156 94 - - HYPH cord-286132-ag2l1xa7 156 95 blind blind JJ cord-286132-ag2l1xa7 156 96 , , , cord-286132-ag2l1xa7 156 97 placebo placebo NN cord-286132-ag2l1xa7 156 98 - - HYPH cord-286132-ag2l1xa7 156 99 controlled control VBN cord-286132-ag2l1xa7 156 100 trial trial NN cord-286132-ag2l1xa7 156 101 ( ( -LRB- cord-286132-ag2l1xa7 156 102 PHOENIX PHOENIX NNP cord-286132-ag2l1xa7 156 103 1 1 CD cord-286132-ag2l1xa7 156 104 ) ) -RRB- cord-286132-ag2l1xa7 157 1 A a DT cord-286132-ag2l1xa7 157 2 human human JJ cord-286132-ag2l1xa7 157 3 interleukin-12/23 interleukin-12/23 NNP cord-286132-ag2l1xa7 157 4 monoclonal monoclonal JJ cord-286132-ag2l1xa7 157 5 antibody antibody NN cord-286132-ag2l1xa7 157 6 for for IN cord-286132-ag2l1xa7 157 7 the the DT cord-286132-ag2l1xa7 157 8 treatment treatment NN cord-286132-ag2l1xa7 157 9 of of IN cord-286132-ag2l1xa7 157 10 psoriasis psoriasis NN cord-286132-ag2l1xa7 157 11 Efficacy Efficacy NNP cord-286132-ag2l1xa7 157 12 and and CC cord-286132-ag2l1xa7 157 13 safety safety NN cord-286132-ag2l1xa7 157 14 of of IN cord-286132-ag2l1xa7 157 15 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 157 16 in in IN cord-286132-ag2l1xa7 157 17 patients patient NNS cord-286132-ag2l1xa7 157 18 with with IN cord-286132-ag2l1xa7 157 19 active active JJ cord-286132-ag2l1xa7 157 20 psoriatic psoriatic JJ cord-286132-ag2l1xa7 157 21 arthritis arthritis NN cord-286132-ag2l1xa7 157 22 : : : cord-286132-ag2l1xa7 157 23 1 1 CD cord-286132-ag2l1xa7 157 24 year year NN cord-286132-ag2l1xa7 157 25 results result NNS cord-286132-ag2l1xa7 157 26 of of IN cord-286132-ag2l1xa7 157 27 the the DT cord-286132-ag2l1xa7 157 28 phase phase NN cord-286132-ag2l1xa7 157 29 3 3 CD cord-286132-ag2l1xa7 157 30 , , , cord-286132-ag2l1xa7 157 31 multicentre multicentre NNP cord-286132-ag2l1xa7 157 32 , , , cord-286132-ag2l1xa7 157 33 double double JJ cord-286132-ag2l1xa7 157 34 - - HYPH cord-286132-ag2l1xa7 157 35 blind blind JJ cord-286132-ag2l1xa7 157 36 , , , cord-286132-ag2l1xa7 157 37 placebo placebo NN cord-286132-ag2l1xa7 157 38 - - HYPH cord-286132-ag2l1xa7 157 39 controlled control VBN cord-286132-ag2l1xa7 157 40 PSUMMIT PSUMMIT NNP cord-286132-ag2l1xa7 157 41 1 1 CD cord-286132-ag2l1xa7 157 42 trial trial NN cord-286132-ag2l1xa7 157 43 Ustekinumab Ustekinumab NNP cord-286132-ag2l1xa7 157 44 , , , cord-286132-ag2l1xa7 157 45 a a DT cord-286132-ag2l1xa7 157 46 human human JJ cord-286132-ag2l1xa7 157 47 interleukin interleukin NN cord-286132-ag2l1xa7 157 48 12/23 12/23 CD cord-286132-ag2l1xa7 157 49 monoclonal monoclonal JJ cord-286132-ag2l1xa7 157 50 antibody antibody NN cord-286132-ag2l1xa7 157 51 , , , cord-286132-ag2l1xa7 157 52 for for IN cord-286132-ag2l1xa7 157 53 psoriatic psoriatic JJ cord-286132-ag2l1xa7 157 54 arthritis arthritis NN cord-286132-ag2l1xa7 157 55 : : : cord-286132-ag2l1xa7 157 56 randomised randomised JJ cord-286132-ag2l1xa7 157 57 , , , cord-286132-ag2l1xa7 157 58 double double JJ cord-286132-ag2l1xa7 157 59 - - HYPH cord-286132-ag2l1xa7 157 60 blind blind JJ cord-286132-ag2l1xa7 157 61 , , , cord-286132-ag2l1xa7 157 62 placebo placebo NN cord-286132-ag2l1xa7 157 63 - - HYPH cord-286132-ag2l1xa7 157 64 controlled control VBN cord-286132-ag2l1xa7 157 65 , , , cord-286132-ag2l1xa7 157 66 crossover crossover NN cord-286132-ag2l1xa7 157 67 trial trial NN cord-286132-ag2l1xa7 157 68 Ustekinumab Ustekinumab NNP cord-286132-ag2l1xa7 157 69 as as IN cord-286132-ag2l1xa7 157 70 Induction Induction NNP cord-286132-ag2l1xa7 157 71 and and CC cord-286132-ag2l1xa7 157 72 Maintenance Maintenance NNP cord-286132-ag2l1xa7 157 73 Therapy Therapy NNP cord-286132-ag2l1xa7 157 74 for for IN cord-286132-ag2l1xa7 157 75 Crohn Crohn NNP cord-286132-ag2l1xa7 157 76 's 's POS cord-286132-ag2l1xa7 157 77 Disease Disease NNP cord-286132-ag2l1xa7 157 78 A A NNP cord-286132-ag2l1xa7 157 79 randomized randomized JJ cord-286132-ag2l1xa7 157 80 trial trial NN cord-286132-ag2l1xa7 157 81 of of IN cord-286132-ag2l1xa7 157 82 Ustekinumab Ustekinumab NNP cord-286132-ag2l1xa7 157 83 monoclonal monoclonal JJ cord-286132-ag2l1xa7 157 84 antibody antibody NN cord-286132-ag2l1xa7 157 85 , , , cord-286132-ag2l1xa7 157 86 in in IN cord-286132-ag2l1xa7 157 87 patients patient NNS cord-286132-ag2l1xa7 157 88 with with IN cord-286132-ag2l1xa7 157 89 moderate moderate JJ cord-286132-ag2l1xa7 157 90 - - HYPH cord-286132-ag2l1xa7 157 91 to to IN cord-286132-ag2l1xa7 157 92 - - HYPH cord-286132-ag2l1xa7 157 93 severe severe JJ cord-286132-ag2l1xa7 157 94 Crohn Crohn NNP cord-286132-ag2l1xa7 157 95 's 's POS cord-286132-ag2l1xa7 157 96 disease disease NN cord-286132-ag2l1xa7 157 97 Efficacy Efficacy NNP cord-286132-ag2l1xa7 157 98 and and CC cord-286132-ag2l1xa7 157 99 safety safety NN cord-286132-ag2l1xa7 157 100 of of IN cord-286132-ag2l1xa7 157 101 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 157 102 treatment treatment NN cord-286132-ag2l1xa7 157 103 in in IN cord-286132-ag2l1xa7 157 104 adults adult NNS cord-286132-ag2l1xa7 157 105 with with IN cord-286132-ag2l1xa7 157 106 moderate moderate JJ cord-286132-ag2l1xa7 157 107 - - HYPH cord-286132-ag2l1xa7 157 108 to to IN cord-286132-ag2l1xa7 157 109 - - HYPH cord-286132-ag2l1xa7 157 110 severe severe JJ cord-286132-ag2l1xa7 157 111 atopic atopic JJ cord-286132-ag2l1xa7 157 112 dermatitis dermatitis NN cord-286132-ag2l1xa7 157 113 Efficacy Efficacy NNP cord-286132-ag2l1xa7 157 114 and and CC cord-286132-ag2l1xa7 157 115 safety safety NN cord-286132-ag2l1xa7 157 116 of of IN cord-286132-ag2l1xa7 157 117 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 157 118 in in IN cord-286132-ag2l1xa7 157 119 Japanese japanese JJ cord-286132-ag2l1xa7 157 120 patients patient NNS cord-286132-ag2l1xa7 157 121 with with IN cord-286132-ag2l1xa7 157 122 severe severe JJ cord-286132-ag2l1xa7 157 123 atopic atopic JJ cord-286132-ag2l1xa7 157 124 dermatitis dermatitis NN cord-286132-ag2l1xa7 157 125 : : : cord-286132-ag2l1xa7 157 126 a a DT cord-286132-ag2l1xa7 157 127 randomized randomized JJ cord-286132-ag2l1xa7 157 128 , , , cord-286132-ag2l1xa7 157 129 double double JJ cord-286132-ag2l1xa7 157 130 - - HYPH cord-286132-ag2l1xa7 157 131 blind blind JJ cord-286132-ag2l1xa7 157 132 , , , cord-286132-ag2l1xa7 157 133 placebo placebo NN cord-286132-ag2l1xa7 157 134 - - HYPH cord-286132-ag2l1xa7 157 135 controlled control VBN cord-286132-ag2l1xa7 157 136 , , , cord-286132-ag2l1xa7 157 137 phase phase NN cord-286132-ag2l1xa7 157 138 II ii CD cord-286132-ag2l1xa7 157 139 study study NN cord-286132-ag2l1xa7 157 140 Efficacy Efficacy NNP cord-286132-ag2l1xa7 157 141 and and CC cord-286132-ag2l1xa7 157 142 safety safety NN cord-286132-ag2l1xa7 157 143 of of IN cord-286132-ag2l1xa7 157 144 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 157 145 inhibitor inhibitor NN cord-286132-ag2l1xa7 157 146 , , , cord-286132-ag2l1xa7 157 147 in in IN cord-286132-ag2l1xa7 157 148 patients patient NNS cord-286132-ag2l1xa7 157 149 with with IN cord-286132-ag2l1xa7 157 150 active active JJ cord-286132-ag2l1xa7 157 151 systemic systemic JJ cord-286132-ag2l1xa7 157 152 lupus lupus NN cord-286132-ag2l1xa7 157 153 erythematosus erythematosus NN cord-286132-ag2l1xa7 157 154 : : : cord-286132-ag2l1xa7 157 155 results result NNS cord-286132-ag2l1xa7 157 156 of of IN cord-286132-ag2l1xa7 157 157 a a DT cord-286132-ag2l1xa7 157 158 multicentre multicentre NN cord-286132-ag2l1xa7 157 159 , , , cord-286132-ag2l1xa7 158 1 double double JJ cord-286132-ag2l1xa7 158 2 - - HYPH cord-286132-ag2l1xa7 158 3 blind blind JJ cord-286132-ag2l1xa7 158 4 , , , cord-286132-ag2l1xa7 158 5 phase phase NN cord-286132-ag2l1xa7 158 6 2 2 CD cord-286132-ag2l1xa7 158 7 , , , cord-286132-ag2l1xa7 158 8 randomised randomised JJ cord-286132-ag2l1xa7 158 9 , , , cord-286132-ag2l1xa7 158 10 controlled controlled JJ cord-286132-ag2l1xa7 158 11 study study NN cord-286132-ag2l1xa7 158 12 Repeated repeat VBD cord-286132-ag2l1xa7 158 13 subcutaneous subcutaneous JJ cord-286132-ag2l1xa7 158 14 injections injection NNS cord-286132-ag2l1xa7 158 15 of of IN cord-286132-ag2l1xa7 158 16 IL12/23 il12/23 CD cord-286132-ag2l1xa7 158 17 p40 p40 CD cord-286132-ag2l1xa7 158 18 neutralising neutralise VBG cord-286132-ag2l1xa7 158 19 antibody antibody NN cord-286132-ag2l1xa7 158 20 , , , cord-286132-ag2l1xa7 158 21 ustekinumab ustekinumab NN cord-286132-ag2l1xa7 158 22 , , , cord-286132-ag2l1xa7 158 23 in in IN cord-286132-ag2l1xa7 158 24 patients patient NNS cord-286132-ag2l1xa7 158 25 with with IN cord-286132-ag2l1xa7 158 26 relapsing relapse VBG cord-286132-ag2l1xa7 158 27 - - HYPH cord-286132-ag2l1xa7 158 28 remitting remit VBG cord-286132-ag2l1xa7 158 29 multiple multiple JJ cord-286132-ag2l1xa7 158 30 sclerosis sclerosis NN cord-286132-ag2l1xa7 158 31 : : : cord-286132-ag2l1xa7 158 32 a a DT cord-286132-ag2l1xa7 158 33 phase phase NN cord-286132-ag2l1xa7 158 34 II ii CD cord-286132-ag2l1xa7 158 35 , , , cord-286132-ag2l1xa7 158 36 double double JJ cord-286132-ag2l1xa7 158 37 - - HYPH cord-286132-ag2l1xa7 158 38 blind blind JJ cord-286132-ag2l1xa7 158 39 , , , cord-286132-ag2l1xa7 158 40 placebo placebo NN cord-286132-ag2l1xa7 158 41 - - HYPH cord-286132-ag2l1xa7 158 42 controlled control VBN cord-286132-ag2l1xa7 158 43 , , , cord-286132-ag2l1xa7 158 44 randomised randomised JJ cord-286132-ag2l1xa7 158 45 , , , cord-286132-ag2l1xa7 158 46 dose dose NN cord-286132-ag2l1xa7 158 47 - - HYPH cord-286132-ag2l1xa7 158 48 ranging range VBG cord-286132-ag2l1xa7 158 49 study study NN