id sid tid token lemma pos cord-274750-fynxciwg 1 1 key key JJ cord-274750-fynxciwg 1 2 : : : cord-274750-fynxciwg 1 3 cord-274750-fynxciwg cord-274750-fynxciwg NNP cord-274750-fynxciwg 2 1 authors author NNS cord-274750-fynxciwg 2 2 : : : cord-274750-fynxciwg 2 3 Peterson Peterson NNP cord-274750-fynxciwg 2 4 , , , cord-274750-fynxciwg 2 5 Danielle Danielle NNP cord-274750-fynxciwg 2 6 ; ; : cord-274750-fynxciwg 2 7 Damsky Damsky NNP cord-274750-fynxciwg 2 8 , , , cord-274750-fynxciwg 2 9 William William NNP cord-274750-fynxciwg 2 10 ; ; : cord-274750-fynxciwg 2 11 King King NNP cord-274750-fynxciwg 2 12 , , , cord-274750-fynxciwg 2 13 Brett Brett NNP cord-274750-fynxciwg 2 14 title title NN cord-274750-fynxciwg 2 15 : : : cord-274750-fynxciwg 3 1 Calm calm JJ cord-274750-fynxciwg 3 2 before before IN cord-274750-fynxciwg 3 3 the the DT cord-274750-fynxciwg 3 4 storm storm NN cord-274750-fynxciwg 3 5 : : : cord-274750-fynxciwg 3 6 understanding understand VBG cord-274750-fynxciwg 3 7 the the DT cord-274750-fynxciwg 3 8 role role NN cord-274750-fynxciwg 3 9 of of IN cord-274750-fynxciwg 3 10 JAK JAK NNP cord-274750-fynxciwg 3 11 inhibitors inhibitor NNS cord-274750-fynxciwg 3 12 in in IN cord-274750-fynxciwg 3 13 COVID-19 covid-19 CD cord-274750-fynxciwg 3 14 date date NN cord-274750-fynxciwg 4 1 : : : cord-274750-fynxciwg 4 2 2020 2020 CD cord-274750-fynxciwg 4 3 - - HYPH cord-274750-fynxciwg 4 4 04 04 CD cord-274750-fynxciwg 4 5 - - SYM cord-274750-fynxciwg 4 6 25 25 CD cord-274750-fynxciwg 4 7 journal journal NN cord-274750-fynxciwg 4 8 : : : cord-274750-fynxciwg 5 1 J J NNP cord-274750-fynxciwg 5 2 Am be VBP cord-274750-fynxciwg 6 1 Acad Acad NNP cord-274750-fynxciwg 6 2 Dermatol Dermatol NNP cord-274750-fynxciwg 7 1 DOI DOI NNP cord-274750-fynxciwg 7 2 : : : cord-274750-fynxciwg 8 1 10.1016 10.1016 CD cord-274750-fynxciwg 8 2 / / SYM cord-274750-fynxciwg 8 3 j.jaad.2020.04.097 j.jaad.2020.04.097 NN cord-274750-fynxciwg 8 4 sha sha NN cord-274750-fynxciwg 8 5 : : : cord-274750-fynxciwg 8 6 7bea0dd1b3112fbe7be23439955f7d0c5271b451 7bea0dd1b3112fbe7be23439955f7d0c5271b451 CD cord-274750-fynxciwg 8 7 doc_id doc_id CD cord-274750-fynxciwg 8 8 : : : cord-274750-fynxciwg 8 9 274750 274750 CD cord-274750-fynxciwg 8 10 cord_uid cord_uid NNS cord-274750-fynxciwg 8 11 : : : cord-274750-fynxciwg 9 1 fynxciwg fynxciwg NNP cord-274750-fynxciwg 9 2 nan nan NNP cord-274750-fynxciwg 9 3 inhibit inhibit VBP cord-274750-fynxciwg 9 4 proteins protein NNS cord-274750-fynxciwg 9 5 potentially potentially RB cord-274750-fynxciwg 9 6 involved involve VBN cord-274750-fynxciwg 9 7 in in IN cord-274750-fynxciwg 9 8 SARS SARS NNP cord-274750-fynxciwg 9 9 - - HYPH cord-274750-fynxciwg 9 10 CoV-2 CoV-2 NNP cord-274750-fynxciwg 9 11 entry entry NN cord-274750-fynxciwg 9 12 into into IN cord-274750-fynxciwg 9 13 cells cell NNS cord-274750-fynxciwg 9 14 . . . cord-274750-fynxciwg 10 1 1 1 LS cord-274750-fynxciwg 11 1 Not not RB cord-274750-fynxciwg 11 2 only only RB cord-274750-fynxciwg 11 3 is be VBZ cord-274750-fynxciwg 11 4 that that IN cord-274750-fynxciwg 11 5 work work NN cord-274750-fynxciwg 11 6 theoretical theoretical JJ cord-274750-fynxciwg 11 7 , , , cord-274750-fynxciwg 11 8 46 46 CD cord-274750-fynxciwg 11 9 that that IN cord-274750-fynxciwg 11 10 this this DT cord-274750-fynxciwg 11 11 potential potential JJ cord-274750-fynxciwg 11 12 inhibition inhibition NN cord-274750-fynxciwg 11 13 might may MD cord-274750-fynxciwg 11 14 provide provide VB cord-274750-fynxciwg 11 15 clinical clinical JJ cord-274750-fynxciwg 11 16 benefit benefit NN cord-274750-fynxciwg 11 17 to to IN cord-274750-fynxciwg 11 18 patients patient NNS cord-274750-fynxciwg 11 19 infected infect VBN cord-274750-fynxciwg 11 20 with with IN cord-274750-fynxciwg 11 21 SARS SARS NNP cord-274750-fynxciwg 11 22 - - HYPH cord-274750-fynxciwg 11 23 CoV-2 CoV-2 NNP cord-274750-fynxciwg 11 24 is be VBZ cord-274750-fynxciwg 11 25 even even RB cord-274750-fynxciwg 11 26 47 47 CD cord-274750-fynxciwg 11 27 further further JJ cord-274750-fynxciwg 11 28 unknown unknown JJ cord-274750-fynxciwg 11 29 . . . cord-274750-fynxciwg 12 1 Also also RB cord-274750-fynxciwg 12 2 , , , cord-274750-fynxciwg 12 3 based base VBN cord-274750-fynxciwg 12 4 on on IN cord-274750-fynxciwg 12 5 in in IN cord-274750-fynxciwg 12 6 vitro vitro FW cord-274750-fynxciwg 12 7 assays assay NNS cord-274750-fynxciwg 12 8 , , , cord-274750-fynxciwg 12 9 the the DT cord-274750-fynxciwg 12 10 concentration concentration NN cord-274750-fynxciwg 12 11 of of IN cord-274750-fynxciwg 12 12 baricitinib baricitinib NNP cord-274750-fynxciwg 12 13 needed need VBD cord-274750-fynxciwg 12 14 to to TO cord-274750-fynxciwg 12 15 inhibit inhibit VB cord-274750-fynxciwg 12 16 48 48 CD cord-274750-fynxciwg 12 17 AAK1 aak1 JJ cord-274750-fynxciwg 12 18 and and CC cord-274750-fynxciwg 12 19 clathrin clathrin NN cord-274750-fynxciwg 12 20 - - HYPH cord-274750-fynxciwg 12 21 mediated mediate VBN cord-274750-fynxciwg 12 22 endocytosis endocytosis NN cord-274750-fynxciwg 12 23 would would MD cord-274750-fynxciwg 12 24 likely likely RB cord-274750-fynxciwg 12 25 require require VB cord-274750-fynxciwg 12 26 doses dose NNS cord-274750-fynxciwg 12 27 far far RB cord-274750-fynxciwg 12 28 above above IN cord-274750-fynxciwg 12 29 the the DT cord-274750-fynxciwg 12 30 FDA FDA NNP cord-274750-fynxciwg 12 31 approved approve VBD cord-274750-fynxciwg 12 32 dose dose NN cord-274750-fynxciwg 12 33 49 49 CD cord-274750-fynxciwg 12 34 of of IN cord-274750-fynxciwg 12 35 baricitinib baricitinib NNP cord-274750-fynxciwg 12 36 2 2 CD cord-274750-fynxciwg 12 37 mg mg NNP cord-274750-fynxciwg 12 38 daily daily RB cord-274750-fynxciwg 12 39 . . . cord-274750-fynxciwg 13 1 2 2 LS cord-274750-fynxciwg 14 1 Lastly lastly RB cord-274750-fynxciwg 14 2 , , , cord-274750-fynxciwg 14 3 the the DT cord-274750-fynxciwg 14 4 theoretical theoretical JJ cord-274750-fynxciwg 14 5 effect effect NN cord-274750-fynxciwg 14 6 against against IN cord-274750-fynxciwg 14 7 viral viral JJ cord-274750-fynxciwg 14 8 endocytosis endocytosis NN cord-274750-fynxciwg 14 9 only only RB cord-274750-fynxciwg 14 10 applies apply VBZ cord-274750-fynxciwg 14 11 to to IN cord-274750-fynxciwg 14 12 50 50 CD cord-274750-fynxciwg 14 13 baricitinib baricitinib NN cord-274750-fynxciwg 14 14 ; ; : cord-274750-fynxciwg 14 15 this this DT cord-274750-fynxciwg 14 16 is be VBZ cord-274750-fynxciwg 14 17 not not RB cord-274750-fynxciwg 14 18 a a DT cord-274750-fynxciwg 14 19 known know VBN cord-274750-fynxciwg 14 20 property property NN cord-274750-fynxciwg 14 21 of of IN cord-274750-fynxciwg 14 22 other other JJ cord-274750-fynxciwg 14 23 JAK JAK NNP cord-274750-fynxciwg 14 24 inhibitors inhibitor NNS cord-274750-fynxciwg 14 25 , , , cord-274750-fynxciwg 14 26 including include VBG cord-274750-fynxciwg 14 27 upadacitinib upadacitinib NN cord-274750-fynxciwg 14 28 . . . cord-274750-fynxciwg 15 1 Based base VBN cord-274750-fynxciwg 15 2 on on IN cord-274750-fynxciwg 15 3 these these DT cord-274750-fynxciwg 15 4 51 51 CD cord-274750-fynxciwg 15 5 considerations consideration NNS cord-274750-fynxciwg 15 6 , , , cord-274750-fynxciwg 15 7 we -PRON- PRP cord-274750-fynxciwg 15 8 believe believe VBP cord-274750-fynxciwg 15 9 there there EX cord-274750-fynxciwg 15 10 is be VBZ cord-274750-fynxciwg 15 11 insufficient insufficient JJ cord-274750-fynxciwg 15 12 evidence evidence NN cord-274750-fynxciwg 15 13 to to TO cord-274750-fynxciwg 15 14 recommend recommend VB cord-274750-fynxciwg 15 15 continuing continue VBG cord-274750-fynxciwg 15 16 JAK JAK NNP cord-274750-fynxciwg 15 17 inhibitors inhibitor NNS cord-274750-fynxciwg 15 18 in in IN cord-274750-fynxciwg 15 19 52 52 CD cord-274750-fynxciwg 15 20 patients patient NNS cord-274750-fynxciwg 15 21 who who WP cord-274750-fynxciwg 15 22 are be VBP cord-274750-fynxciwg 15 23 acutely acutely RB cord-274750-fynxciwg 15 24 infected infect VBN cord-274750-fynxciwg 15 25 with with IN cord-274750-fynxciwg 15 26 SARS SARS NNP cord-274750-fynxciwg 15 27 - - HYPH cord-274750-fynxciwg 15 28 CoV-2 CoV-2 NNP cord-274750-fynxciwg 15 29 . . . cord-274750-fynxciwg 16 1 53 53 CD cord-274750-fynxciwg 16 2 54 54 CD cord-274750-fynxciwg 17 1 Napolitano Napolitano NNP cord-274750-fynxciwg 17 2 et et NNP cord-274750-fynxciwg 17 3 al al NNP cord-274750-fynxciwg 17 4 suggest suggest VBP cord-274750-fynxciwg 17 5 that that IN cord-274750-fynxciwg 17 6 baricitinib baricitinib NN cord-274750-fynxciwg 17 7 and and CC cord-274750-fynxciwg 17 8 upadacitinib upadacitinib NN cord-274750-fynxciwg 17 9 might may MD cord-274750-fynxciwg 17 10 be be VB cord-274750-fynxciwg 17 11 useful useful JJ cord-274750-fynxciwg 17 12 in in IN cord-274750-fynxciwg 17 13 treating treat VBG cord-274750-fynxciwg 17 14 the the DT cord-274750-fynxciwg 17 15 cytokine cytokine NN cord-274750-fynxciwg 17 16 55 55 CD cord-274750-fynxciwg 17 17 release release NN cord-274750-fynxciwg 17 18 syndrome syndrome NN cord-274750-fynxciwg 17 19 ( ( -LRB- cord-274750-fynxciwg 17 20 CRS CRS NNP cord-274750-fynxciwg 17 21 ) ) -RRB- cord-274750-fynxciwg 17 22 that that WDT cord-274750-fynxciwg 17 23 can can MD cord-274750-fynxciwg 17 24 occur occur VB cord-274750-fynxciwg 17 25 in in IN cord-274750-fynxciwg 17 26 SARS SARS NNP cord-274750-fynxciwg 17 27 - - HYPH cord-274750-fynxciwg 17 28 CoV-2 CoV-2 NNP cord-274750-fynxciwg 17 29 infection infection NN cord-274750-fynxciwg 17 30 . . . cord-274750-fynxciwg 18 1 We -PRON- PRP cord-274750-fynxciwg 18 2 strongly strongly RB cord-274750-fynxciwg 18 3 agree agree VBP cord-274750-fynxciwg 18 4 that that IN cord-274750-fynxciwg 18 5 there there EX cord-274750-fynxciwg 18 6 may may MD cord-274750-fynxciwg 18 7 be be VB cord-274750-fynxciwg 18 8 a a DT cord-274750-fynxciwg 18 9 56 56 CD cord-274750-fynxciwg 18 10 role role NN cord-274750-fynxciwg 18 11 for for IN cord-274750-fynxciwg 18 12 JAK JAK NNP cord-274750-fynxciwg 18 13 inhibitors inhibitor NNS cord-274750-fynxciwg 18 14 in in IN cord-274750-fynxciwg 18 15 treating treat VBG cord-274750-fynxciwg 18 16 SARS SARS NNP cord-274750-fynxciwg 18 17 - - HYPH cord-274750-fynxciwg 18 18 CoV-2-associated cov-2-associate VBN cord-274750-fynxciwg 18 19 CRS CRS NNP cord-274750-fynxciwg 18 20 . . . cord-274750-fynxciwg 19 1 However however RB cord-274750-fynxciwg 19 2 , , , cord-274750-fynxciwg 19 3 it -PRON- PRP cord-274750-fynxciwg 19 4 is be VBZ cord-274750-fynxciwg 19 5 important important JJ cord-274750-fynxciwg 19 6 to to TO cord-274750-fynxciwg 19 7 note note VB cord-274750-fynxciwg 19 8 that that IN cord-274750-fynxciwg 19 9 this this DT cord-274750-fynxciwg 19 10 57 57 CD cord-274750-fynxciwg 19 11 is be VBZ cord-274750-fynxciwg 19 12 typically typically RB cord-274750-fynxciwg 19 13 a a DT cord-274750-fynxciwg 19 14 late late JJ cord-274750-fynxciwg 19 15 manifestation manifestation NN cord-274750-fynxciwg 19 16 of of IN cord-274750-fynxciwg 19 17 disease disease NN cord-274750-fynxciwg 19 18 that that WDT cord-274750-fynxciwg 19 19 occurs occur VBZ cord-274750-fynxciwg 19 20 only only RB cord-274750-fynxciwg 19 21 in in IN cord-274750-fynxciwg 19 22 a a DT cord-274750-fynxciwg 19 23 subset subset NN cord-274750-fynxciwg 19 24 of of IN cord-274750-fynxciwg 19 25 patients patient NNS cord-274750-fynxciwg 19 26 . . . cord-274750-fynxciwg 20 1 Furthermore furthermore RB cord-274750-fynxciwg 20 2 , , , cord-274750-fynxciwg 20 3 there there EX cord-274750-fynxciwg 20 4 is be VBZ cord-274750-fynxciwg 20 5 58 58 CD cord-274750-fynxciwg 20 6 evidence evidence NN cord-274750-fynxciwg 20 7 in in IN cord-274750-fynxciwg 20 8 both both DT cord-274750-fynxciwg 20 9 rhesus rhesus NN cord-274750-fynxciwg 20 10 macaques macaque NNS cord-274750-fynxciwg 20 11 and and CC cord-274750-fynxciwg 20 12 mice mouse NNS cord-274750-fynxciwg 20 13 infected infect VBN cord-274750-fynxciwg 20 14 with with IN cord-274750-fynxciwg 20 15 the the DT cord-274750-fynxciwg 20 16 original original JJ cord-274750-fynxciwg 20 17 SARS SARS NNP cord-274750-fynxciwg 20 18 virus virus NN cord-274750-fynxciwg 20 19 , , , cord-274750-fynxciwg 20 20 SARS SARS NNP cord-274750-fynxciwg 20 21 - - HYPH cord-274750-fynxciwg 20 22 CoV CoV NNP cord-274750-fynxciwg 20 23 , , , cord-274750-fynxciwg 20 24 that that IN cord-274750-fynxciwg 20 25 a a DT cord-274750-fynxciwg 20 26 59 59 CD cord-274750-fynxciwg 20 27 suboptimal suboptimal JJ cord-274750-fynxciwg 20 28 early early JJ cord-274750-fynxciwg 20 29 anti anti JJ cord-274750-fynxciwg 20 30 - - JJ cord-274750-fynxciwg 20 31 viral viral JJ cord-274750-fynxciwg 20 32 type type NN cord-274750-fynxciwg 20 33 I -PRON- PRP cord-274750-fynxciwg 20 34 interferon interferon VBD cord-274750-fynxciwg 20 35 response response NN cord-274750-fynxciwg 20 36 may may MD cord-274750-fynxciwg 20 37 predispose predispose VB cord-274750-fynxciwg 20 38 to to IN cord-274750-fynxciwg 20 39 this this DT cord-274750-fynxciwg 20 40 late late JJ cord-274750-fynxciwg 20 41 manifestation manifestation NN cord-274750-fynxciwg 20 42 . . . cord-274750-fynxciwg 21 1 3,4 3,4 CD cord-274750-fynxciwg 21 2 JAK JAK NNP cord-274750-fynxciwg 21 3 60 60 CD cord-274750-fynxciwg 21 4 cytokines cytokine NNS cord-274750-fynxciwg 21 5 including include VBG cord-274750-fynxciwg 21 6 IL-2 IL-2 NNP cord-274750-fynxciwg 21 7 , , , cord-274750-fynxciwg 21 8 interferon interferon NN cord-274750-fynxciwg 21 9 gamma gamma NN cord-274750-fynxciwg 21 10 , , , cord-274750-fynxciwg 21 11 GM GM NNP cord-274750-fynxciwg 21 12 - - HYPH cord-274750-fynxciwg 21 13 CSF CSF NNP cord-274750-fynxciwg 21 14 , , , cord-274750-fynxciwg 21 15 and and CC cord-274750-fynxciwg 21 16 G G NNP cord-274750-fynxciwg 21 17 - - HYPH cord-274750-fynxciwg 21 18 CSF CSF NNP cord-274750-fynxciwg 21 19 . . . cord-274750-fynxciwg 22 1 Important important JJ cord-274750-fynxciwg 22 2 to to TO cord-274750-fynxciwg 22 3 note note VB cord-274750-fynxciwg 22 4 is be VBZ cord-274750-fynxciwg 22 5 that that IN cord-274750-fynxciwg 22 6 the the DT cord-274750-fynxciwg 22 7 64 64 CD cord-274750-fynxciwg 22 8 theoretical theoretical JJ cord-274750-fynxciwg 22 9 benefit benefit NN cord-274750-fynxciwg 22 10 of of IN cord-274750-fynxciwg 22 11 JAK JAK NNP cord-274750-fynxciwg 22 12 inhibitors inhibitor NNS cord-274750-fynxciwg 22 13 in in IN cord-274750-fynxciwg 22 14 this this DT cord-274750-fynxciwg 22 15 setting setting NN cord-274750-fynxciwg 22 16 is be VBZ cord-274750-fynxciwg 22 17 not not RB cord-274750-fynxciwg 22 18 limited limited JJ cord-274750-fynxciwg 22 19 to to IN cord-274750-fynxciwg 22 20 upadacitinib upadacitinib NN cord-274750-fynxciwg 22 21 and and CC cord-274750-fynxciwg 22 22 baricitinib baricitinib NN cord-274750-fynxciwg 22 23 but but CC cord-274750-fynxciwg 22 24 also also RB cord-274750-fynxciwg 22 25 65 65 CD cord-274750-fynxciwg 22 26 applies apply VBZ cord-274750-fynxciwg 22 27 to to IN cord-274750-fynxciwg 22 28 other other JJ cord-274750-fynxciwg 22 29 JAK JAK NNP cord-274750-fynxciwg 22 30 inhibitors inhibitor NNS cord-274750-fynxciwg 22 31 including include VBG cord-274750-fynxciwg 22 32 ruxolitinib ruxolitinib NNP cord-274750-fynxciwg 22 33 and and CC cord-274750-fynxciwg 22 34 tofacitinib tofacitinib NNP cord-274750-fynxciwg 22 35 . . . cord-274750-fynxciwg 23 1 We -PRON- PRP cord-274750-fynxciwg 23 2 and and CC cord-274750-fynxciwg 23 3 others other NNS cord-274750-fynxciwg 23 4 are be VBP cord-274750-fynxciwg 23 5 undertaking undertake VBG cord-274750-fynxciwg 23 6 66 66 CD cord-274750-fynxciwg 23 7 clinical clinical JJ cord-274750-fynxciwg 23 8 trials trial NNS cord-274750-fynxciwg 23 9 to to TO cord-274750-fynxciwg 23 10 evaluate evaluate VB cord-274750-fynxciwg 23 11 JAK JAK NNP cord-274750-fynxciwg 23 12 inhibitors inhibitor NNS cord-274750-fynxciwg 23 13 for for IN cord-274750-fynxciwg 23 14 SARS SARS NNP cord-274750-fynxciwg 23 15 - - HYPH cord-274750-fynxciwg 23 16 CoV-2-associated cov-2-associate VBN cord-274750-fynxciwg 23 17 CRS CRS NNP cord-274750-fynxciwg 23 18 , , , cord-274750-fynxciwg 23 19 and and CC cord-274750-fynxciwg 23 20 it -PRON- PRP cord-274750-fynxciwg 23 21 will will MD cord-274750-fynxciwg 23 22 be be VB cord-274750-fynxciwg 23 23 interesting interesting JJ cord-274750-fynxciwg 23 24 to to TO cord-274750-fynxciwg 23 25 see see VB cord-274750-fynxciwg 23 26 67 67 CD cord-274750-fynxciwg 23 27 what what WP cord-274750-fynxciwg 23 28 they -PRON- PRP cord-274750-fynxciwg 23 29 show show VBP cord-274750-fynxciwg 23 30 . . . cord-274750-fynxciwg 24 1 68 68 CD cord-274750-fynxciwg 25 1 In in IN cord-274750-fynxciwg 25 2 summary summary NN cord-274750-fynxciwg 25 3 , , , cord-274750-fynxciwg 25 4 we -PRON- PRP cord-274750-fynxciwg 25 5 believe believe VBP cord-274750-fynxciwg 25 6 there there EX cord-274750-fynxciwg 25 7 is be VBZ cord-274750-fynxciwg 25 8 insufficient insufficient JJ cord-274750-fynxciwg 25 9 evidence evidence NN cord-274750-fynxciwg 25 10 to to TO cord-274750-fynxciwg 25 11 recommend recommend VB cord-274750-fynxciwg 25 12 that that IN cord-274750-fynxciwg 25 13 JAK JAK NNP cord-274750-fynxciwg 25 14 inhibitors inhibitor NNS cord-274750-fynxciwg 25 15 be be VB cord-274750-fynxciwg 25 16 continued continue VBN cord-274750-fynxciwg 25 17 in in IN cord-274750-fynxciwg 25 18 70 70 CD cord-274750-fynxciwg 25 19 all all DT cord-274750-fynxciwg 25 20 patients patient NNS cord-274750-fynxciwg 25 21 taking take VBG cord-274750-fynxciwg 25 22 these these DT cord-274750-fynxciwg 25 23 medications medication NNS cord-274750-fynxciwg 25 24 who who WP cord-274750-fynxciwg 25 25 are be VBP cord-274750-fynxciwg 25 26 acutely acutely RB cord-274750-fynxciwg 25 27 infected infect VBN cord-274750-fynxciwg 25 28 with with IN cord-274750-fynxciwg 25 29 SARS SARS NNP cord-274750-fynxciwg 25 30 - - HYPH cord-274750-fynxciwg 25 31 CoV-2 CoV-2 NNP cord-274750-fynxciwg 25 32 . . . cord-274750-fynxciwg 26 1 While while IN cord-274750-fynxciwg 26 2 JAK JAK NNP cord-274750-fynxciwg 26 3 inhibitors inhibitor NNS cord-274750-fynxciwg 26 4 71 71 CD cord-274750-fynxciwg 26 5 may may MD cord-274750-fynxciwg 26 6 prove prove VB cord-274750-fynxciwg 26 7 useful useful JJ cord-274750-fynxciwg 26 8 in in IN cord-274750-fynxciwg 26 9 the the DT cord-274750-fynxciwg 26 10 treatment treatment NN cord-274750-fynxciwg 26 11 of of IN cord-274750-fynxciwg 26 12 SARS SARS NNP cord-274750-fynxciwg 26 13 - - HYPH cord-274750-fynxciwg 26 14 CoV-2-associated cov-2-associate VBN cord-274750-fynxciwg 26 15 CRS CRS NNP cord-274750-fynxciwg 26 16 , , , cord-274750-fynxciwg 26 17 this this DT cord-274750-fynxciwg 26 18 is be VBZ cord-274750-fynxciwg 26 19 a a DT cord-274750-fynxciwg 26 20 separate separate JJ cord-274750-fynxciwg 26 21 consideration consideration NN cord-274750-fynxciwg 26 22 of of IN cord-274750-fynxciwg 26 23 a a DT cord-274750-fynxciwg 26 24 72 72 CD cord-274750-fynxciwg 26 25 relatively relatively RB cord-274750-fynxciwg 26 26 uncommon uncommon JJ cord-274750-fynxciwg 26 27 manifestation manifestation NN cord-274750-fynxciwg 26 28 of of IN cord-274750-fynxciwg 26 29 this this DT cord-274750-fynxciwg 26 30 viral viral JJ cord-274750-fynxciwg 26 31 infection infection NN cord-274750-fynxciwg 26 32 that that WDT cord-274750-fynxciwg 26 33 occurs occur VBZ cord-274750-fynxciwg 26 34 late late RB cord-274750-fynxciwg 26 35 in in IN cord-274750-fynxciwg 26 36 disease disease NN cord-274750-fynxciwg 26 37 course course NN cord-274750-fynxciwg 26 38 . . . cord-274750-fynxciwg 27 1 73 73 CD cord-274750-fynxciwg 27 2 74 74 CD cord-274750-fynxciwg 27 3 75 75 CD cord-274750-fynxciwg 27 4 76 76 CD cord-274750-fynxciwg 27 5 Baricitinib Baricitinib NNP cord-274750-fynxciwg 27 6 as as IN cord-274750-fynxciwg 27 7 potential potential JJ cord-274750-fynxciwg 27 8 treatment treatment NN cord-274750-fynxciwg 27 9 for for IN cord-274750-fynxciwg 27 10 2019-nCoV 2019-ncov CD cord-274750-fynxciwg 27 11 acute acute JJ cord-274750-fynxciwg 27 12 78 78 CD cord-274750-fynxciwg 27 13 respiratory respiratory JJ cord-274750-fynxciwg 27 14 disease disease NN cord-274750-fynxciwg 27 15 COVID-19 covid-19 NN cord-274750-fynxciwg 27 16 : : : cord-274750-fynxciwg 27 17 combining combine VBG cord-274750-fynxciwg 27 18 antiviral antiviral JJ cord-274750-fynxciwg 27 19 and and CC cord-274750-fynxciwg 27 20 anti anti JJ cord-274750-fynxciwg 27 21 - - JJ cord-274750-fynxciwg 27 22 inflammatory inflammatory JJ cord-274750-fynxciwg 27 23 80 80 CD cord-274750-fynxciwg 27 24 treatments treatment NNS cord-274750-fynxciwg 28 1 Dysregulated Dysregulated NNP cord-274750-fynxciwg 28 2 Type Type NNP cord-274750-fynxciwg 29 1 I -PRON- PRP cord-274750-fynxciwg 30 1 Interferon interferon NN cord-274750-fynxciwg 30 2 and and CC cord-274750-fynxciwg 30 3 Inflammatory Inflammatory NNP cord-274750-fynxciwg 30 4 82 82 CD cord-274750-fynxciwg 30 5 Responses response NNS cord-274750-fynxciwg 30 6 Cause cause VBP cord-274750-fynxciwg 30 7 Lethal lethal JJ cord-274750-fynxciwg 30 8 Pneumonia pneumonia NN cord-274750-fynxciwg 30 9 in in IN cord-274750-fynxciwg 31 1 SARS SARS NNP cord-274750-fynxciwg 31 2 - - HYPH cord-274750-fynxciwg 31 3 CoV CoV NNP cord-274750-fynxciwg 31 4 - - HYPH cord-274750-fynxciwg 31 5 Infected infected JJ cord-274750-fynxciwg 31 6 Mice Mice NNP cord-274750-fynxciwg 31 7 Microbe microbe NN cord-274750-fynxciwg 31 8 Exacerbated exacerbate VBN cord-274750-fynxciwg 32 1 Innate Innate NNP cord-274750-fynxciwg 32 2 Host Host NNP cord-274750-fynxciwg 32 3 Response Response NNP cord-274750-fynxciwg 32 4 to to IN cord-274750-fynxciwg 32 5 SARS SARS NNP cord-274750-fynxciwg 32 6 - - HYPH cord-274750-fynxciwg 32 7 CoV CoV NNP cord-274750-fynxciwg 32 8 in in IN cord-274750-fynxciwg 32 9 85 85 CD cord-274750-fynxciwg 32 10 Aged aged JJ cord-274750-fynxciwg 32 11 Non Non NNP cord-274750-fynxciwg 32 12 - - JJ cord-274750-fynxciwg 32 13 Human human JJ cord-274750-fynxciwg 32 14 Primates Primates NNPS cord-274750-fynxciwg 32 15 . . . cord-274750-fynxciwg 33 1 Baric Baric NNP cord-274750-fynxciwg 33 2 RS rs NN