id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-308212-l8flyso7	Kong, Ha Eun	Applying the ethical principles of resource allocation to drugs in limited supply during a public health crisis	2020-04-21		.txt	text/plain	565	51	52	title: Applying the ethical principles of resource allocation to drugs in limited supply during a public health crisis Applying this principle to antimalarials, severe 47 COVID-19 patients as well as patients with malaria or severe rheumatologic disease, for whom 48 other effective treatments are unavailable, should be favored. In contrast, for systemic lupus erythematosus (SLE) 58 patients, a RCT showed that discontinuing hydroxychloroquine leads to a 2.5x increased 59 relative risk of clinically-relevant flares and a 6x increased relative risk of severe exacerbation 60 compared to placebo 4 . Under normal 63 circumstances, if a reasonable patient prefers antimalarials for skin disease, and the treatment 64 is indicated, then the drugs should be prescribed. However, patient autonomy is diminished in 65 public health emergencies, as healthcare ethics shifts priority to populations over individuals 5 . "Application of ethical principles of resource allocation in the COVID-19 pandemic" 107 (adapted from Emanuel et al. Hydroxychloroquine and azithromycin as a 86 treatment of COVID-19: results of an open-label non-randomized clinical trial	./cache/cord-308212-l8flyso7.txt	./txt/cord-308212-l8flyso7.txt