id sid tid token lemma pos cord-261058-yu2qw02l 1 1 key key JJ cord-261058-yu2qw02l 2 1 : : : cord-261058-yu2qw02l 2 2 cord-261058-yu2qw02l cord-261058-yu2qw02l NNP cord-261058-yu2qw02l 2 3 authors author NNS cord-261058-yu2qw02l 2 4 : : : cord-261058-yu2qw02l 2 5 Burgner Burgner NNP cord-261058-yu2qw02l 2 6 , , , cord-261058-yu2qw02l 2 7 David David NNP cord-261058-yu2qw02l 2 8 ; ; : cord-261058-yu2qw02l 2 9 Harnden Harnden NNP cord-261058-yu2qw02l 2 10 , , , cord-261058-yu2qw02l 2 11 Anthony Anthony NNP cord-261058-yu2qw02l 2 12 title title NN cord-261058-yu2qw02l 2 13 : : : cord-261058-yu2qw02l 2 14 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 2 15 disease disease NN cord-261058-yu2qw02l 2 16 : : : cord-261058-yu2qw02l 3 1 What what WP cord-261058-yu2qw02l 3 2 is be VBZ cord-261058-yu2qw02l 3 3 the the DT cord-261058-yu2qw02l 3 4 epidemiology epidemiology NN cord-261058-yu2qw02l 3 5 telling tell VBG cord-261058-yu2qw02l 3 6 us -PRON- PRP cord-261058-yu2qw02l 3 7 about about IN cord-261058-yu2qw02l 3 8 the the DT cord-261058-yu2qw02l 3 9 etiology etiology NN cord-261058-yu2qw02l 3 10 ? ? . cord-261058-yu2qw02l 4 1 date date NN cord-261058-yu2qw02l 4 2 : : : cord-261058-yu2qw02l 4 3 2005 2005 CD cord-261058-yu2qw02l 4 4 - - HYPH cord-261058-yu2qw02l 4 5 06 06 CD cord-261058-yu2qw02l 4 6 - - HYPH cord-261058-yu2qw02l 4 7 03 03 CD cord-261058-yu2qw02l 4 8 journal journal NN cord-261058-yu2qw02l 4 9 : : : cord-261058-yu2qw02l 5 1 Int Int NNP cord-261058-yu2qw02l 5 2 J J NNP cord-261058-yu2qw02l 5 3 Infect infect VB cord-261058-yu2qw02l 5 4 Dis Dis NNP cord-261058-yu2qw02l 5 5 DOI doi NN cord-261058-yu2qw02l 5 6 : : : cord-261058-yu2qw02l 5 7 10.1016/ 10.1016/ CD cord-261058-yu2qw02l 6 1 j.ijid.2005.03.002 j.ijid.2005.03.002 NNP cord-261058-yu2qw02l 6 2 sha sha NNP cord-261058-yu2qw02l 6 3 : : : cord-261058-yu2qw02l 6 4 b58a690b4fdad93fa4964ef11183145b6107f9b5 b58a690b4fdad93fa4964ef11183145b6107f9b5 LS cord-261058-yu2qw02l 6 5 doc_id doc_id CD cord-261058-yu2qw02l 6 6 : : : cord-261058-yu2qw02l 6 7 261058 261058 CD cord-261058-yu2qw02l 6 8 cord_uid cord_uid NNS cord-261058-yu2qw02l 6 9 : : : cord-261058-yu2qw02l 7 1 yu2qw02l yu2qw02l NNP cord-261058-yu2qw02l 7 2 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 7 3 disease disease NN cord-261058-yu2qw02l 7 4 ( ( -LRB- cord-261058-yu2qw02l 7 5 KD KD NNP cord-261058-yu2qw02l 7 6 ) ) -RRB- cord-261058-yu2qw02l 7 7 is be VBZ cord-261058-yu2qw02l 7 8 an an DT cord-261058-yu2qw02l 7 9 important important JJ cord-261058-yu2qw02l 7 10 and and CC cord-261058-yu2qw02l 7 11 common common JJ cord-261058-yu2qw02l 7 12 inflammatory inflammatory JJ cord-261058-yu2qw02l 7 13 vasculitis vasculitis NN cord-261058-yu2qw02l 7 14 of of IN cord-261058-yu2qw02l 7 15 early early JJ cord-261058-yu2qw02l 7 16 childhood childhood NN cord-261058-yu2qw02l 7 17 with with IN cord-261058-yu2qw02l 7 18 a a DT cord-261058-yu2qw02l 7 19 striking striking JJ cord-261058-yu2qw02l 7 20 predilection predilection NN cord-261058-yu2qw02l 7 21 for for IN cord-261058-yu2qw02l 7 22 the the DT cord-261058-yu2qw02l 7 23 coronary coronary JJ cord-261058-yu2qw02l 7 24 arteries artery NNS cord-261058-yu2qw02l 7 25 . . . cord-261058-yu2qw02l 8 1 It -PRON- PRP cord-261058-yu2qw02l 8 2 is be VBZ cord-261058-yu2qw02l 8 3 the the DT cord-261058-yu2qw02l 8 4 predominant predominant JJ cord-261058-yu2qw02l 8 5 cause cause NN cord-261058-yu2qw02l 8 6 of of IN cord-261058-yu2qw02l 8 7 paediatric paediatric JJ cord-261058-yu2qw02l 8 8 acquired acquire VBN cord-261058-yu2qw02l 8 9 heart heart NN cord-261058-yu2qw02l 8 10 disease disease NN cord-261058-yu2qw02l 8 11 in in IN cord-261058-yu2qw02l 8 12 developed develop VBN cord-261058-yu2qw02l 8 13 countries country NNS cord-261058-yu2qw02l 8 14 . . . cord-261058-yu2qw02l 9 1 Despite despite IN cord-261058-yu2qw02l 9 2 40 40 CD cord-261058-yu2qw02l 9 3 years year NNS cord-261058-yu2qw02l 9 4 of of IN cord-261058-yu2qw02l 9 5 research research NN cord-261058-yu2qw02l 9 6 , , , cord-261058-yu2qw02l 9 7 the the DT cord-261058-yu2qw02l 9 8 aetiology aetiology NN cord-261058-yu2qw02l 9 9 of of IN cord-261058-yu2qw02l 9 10 KD KD NNP cord-261058-yu2qw02l 9 11 remains remain VBZ cord-261058-yu2qw02l 9 12 unknown unknown JJ cord-261058-yu2qw02l 9 13 and and CC cord-261058-yu2qw02l 9 14 consequently consequently RB cord-261058-yu2qw02l 9 15 there there EX cord-261058-yu2qw02l 9 16 is be VBZ cord-261058-yu2qw02l 9 17 no no DT cord-261058-yu2qw02l 9 18 diagnostic diagnostic JJ cord-261058-yu2qw02l 9 19 test test NN cord-261058-yu2qw02l 9 20 and and CC cord-261058-yu2qw02l 9 21 treatment treatment NN cord-261058-yu2qw02l 9 22 is be VBZ cord-261058-yu2qw02l 9 23 non non JJ cord-261058-yu2qw02l 9 24 - - JJ cord-261058-yu2qw02l 9 25 specific specific JJ cord-261058-yu2qw02l 9 26 and and CC cord-261058-yu2qw02l 9 27 sub sub JJ cord-261058-yu2qw02l 9 28 - - JJ cord-261058-yu2qw02l 9 29 optimal optimal JJ cord-261058-yu2qw02l 9 30 . . . cord-261058-yu2qw02l 10 1 The the DT cord-261058-yu2qw02l 10 2 consensus consensus NN cord-261058-yu2qw02l 10 3 is be VBZ cord-261058-yu2qw02l 10 4 that that IN cord-261058-yu2qw02l 10 5 KD KD NNP cord-261058-yu2qw02l 10 6 is be VBZ cord-261058-yu2qw02l 10 7 due due JJ cord-261058-yu2qw02l 10 8 to to IN cord-261058-yu2qw02l 10 9 one one CD cord-261058-yu2qw02l 10 10 or or CC cord-261058-yu2qw02l 10 11 more more RBR cord-261058-yu2qw02l 10 12 widely widely RB cord-261058-yu2qw02l 10 13 distributed distribute VBN cord-261058-yu2qw02l 10 14 infectious infectious JJ cord-261058-yu2qw02l 10 15 agent(s agent(s NNP cord-261058-yu2qw02l 10 16 ) ) -RRB- cord-261058-yu2qw02l 10 17 , , , cord-261058-yu2qw02l 10 18 which which WDT cord-261058-yu2qw02l 10 19 evoke evoke VBP cord-261058-yu2qw02l 10 20 an an DT cord-261058-yu2qw02l 10 21 abnormal abnormal JJ cord-261058-yu2qw02l 10 22 immunological immunological JJ cord-261058-yu2qw02l 10 23 response response NN cord-261058-yu2qw02l 10 24 in in IN cord-261058-yu2qw02l 10 25 genetically genetically RB cord-261058-yu2qw02l 10 26 susceptible susceptible JJ cord-261058-yu2qw02l 10 27 individuals individual NNS cord-261058-yu2qw02l 10 28 . . . cord-261058-yu2qw02l 11 1 The the DT cord-261058-yu2qw02l 11 2 epidemiology epidemiology NN cord-261058-yu2qw02l 11 3 of of IN cord-261058-yu2qw02l 11 4 KD KD NNP cord-261058-yu2qw02l 11 5 has have VBZ cord-261058-yu2qw02l 11 6 been be VBN cord-261058-yu2qw02l 11 7 extensively extensively RB cord-261058-yu2qw02l 11 8 investigated investigate VBN cord-261058-yu2qw02l 11 9 in in IN cord-261058-yu2qw02l 11 10 many many JJ cord-261058-yu2qw02l 11 11 populations population NNS cord-261058-yu2qw02l 11 12 and and CC cord-261058-yu2qw02l 11 13 provides provide VBZ cord-261058-yu2qw02l 11 14 much much JJ cord-261058-yu2qw02l 11 15 of of IN cord-261058-yu2qw02l 11 16 the the DT cord-261058-yu2qw02l 11 17 supporting support VBG cord-261058-yu2qw02l 11 18 evidence evidence NN cord-261058-yu2qw02l 11 19 for for IN cord-261058-yu2qw02l 11 20 the the DT cord-261058-yu2qw02l 11 21 consensus consensus NN cord-261058-yu2qw02l 11 22 regarding regard VBG cord-261058-yu2qw02l 11 23 etiology etiology NN cord-261058-yu2qw02l 11 24 . . . cord-261058-yu2qw02l 12 1 These these DT cord-261058-yu2qw02l 12 2 epidemiological epidemiological JJ cord-261058-yu2qw02l 12 3 data datum NNS cord-261058-yu2qw02l 12 4 are be VBP cord-261058-yu2qw02l 12 5 reviewed review VBN cord-261058-yu2qw02l 12 6 here here RB cord-261058-yu2qw02l 12 7 , , , cord-261058-yu2qw02l 12 8 in in IN cord-261058-yu2qw02l 12 9 the the DT cord-261058-yu2qw02l 12 10 context context NN cord-261058-yu2qw02l 12 11 of of IN cord-261058-yu2qw02l 12 12 the the DT cord-261058-yu2qw02l 12 13 etiopathogenesis etiopathogenesis NN cord-261058-yu2qw02l 12 14 . . . cord-261058-yu2qw02l 13 1 It -PRON- PRP cord-261058-yu2qw02l 13 2 is be VBZ cord-261058-yu2qw02l 13 3 suggested suggest VBN cord-261058-yu2qw02l 13 4 that that IN cord-261058-yu2qw02l 13 5 these these DT cord-261058-yu2qw02l 13 6 data datum NNS cord-261058-yu2qw02l 13 7 provide provide VBP cord-261058-yu2qw02l 13 8 additional additional JJ cord-261058-yu2qw02l 13 9 clues clue NNS cord-261058-yu2qw02l 13 10 regarding regard VBG cord-261058-yu2qw02l 13 11 the the DT cord-261058-yu2qw02l 13 12 cause cause NN cord-261058-yu2qw02l 13 13 of of IN cord-261058-yu2qw02l 13 14 KD KD NNP cord-261058-yu2qw02l 13 15 and and CC cord-261058-yu2qw02l 13 16 may may MD cord-261058-yu2qw02l 13 17 account account VB cord-261058-yu2qw02l 13 18 for for IN cord-261058-yu2qw02l 13 19 some some DT cord-261058-yu2qw02l 13 20 of of IN cord-261058-yu2qw02l 13 21 the the DT cord-261058-yu2qw02l 13 22 continuing continue VBG cord-261058-yu2qw02l 13 23 controversies controversy NNS cord-261058-yu2qw02l 13 24 in in IN cord-261058-yu2qw02l 13 25 the the DT cord-261058-yu2qw02l 13 26 field field NN cord-261058-yu2qw02l 13 27 . . . cord-261058-yu2qw02l 14 1 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 14 2 disease disease NN cord-261058-yu2qw02l 14 3 ; ; : cord-261058-yu2qw02l 14 4 Vasculitis vasculitis NN cord-261058-yu2qw02l 14 5 ; ; : cord-261058-yu2qw02l 14 6 Genetics genetic NNS cord-261058-yu2qw02l 14 7 ; ; : cord-261058-yu2qw02l 14 8 Epidemiology epidemiology NN cord-261058-yu2qw02l 14 9 ; ; : cord-261058-yu2qw02l 14 10 Inflammation inflammation NN cord-261058-yu2qw02l 14 11 Summary Summary NNP cord-261058-yu2qw02l 14 12 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 14 13 disease disease NN cord-261058-yu2qw02l 14 14 ( ( -LRB- cord-261058-yu2qw02l 14 15 KD KD NNP cord-261058-yu2qw02l 14 16 ) ) -RRB- cord-261058-yu2qw02l 14 17 is be VBZ cord-261058-yu2qw02l 14 18 an an DT cord-261058-yu2qw02l 14 19 important important JJ cord-261058-yu2qw02l 14 20 and and CC cord-261058-yu2qw02l 14 21 common common JJ cord-261058-yu2qw02l 14 22 inflammatory inflammatory JJ cord-261058-yu2qw02l 14 23 vasculitis vasculitis NN cord-261058-yu2qw02l 14 24 of of IN cord-261058-yu2qw02l 14 25 early early JJ cord-261058-yu2qw02l 14 26 childhood childhood NN cord-261058-yu2qw02l 14 27 with with IN cord-261058-yu2qw02l 14 28 a a DT cord-261058-yu2qw02l 14 29 striking striking JJ cord-261058-yu2qw02l 14 30 predilection predilection NN cord-261058-yu2qw02l 14 31 for for IN cord-261058-yu2qw02l 14 32 the the DT cord-261058-yu2qw02l 14 33 coronary coronary JJ cord-261058-yu2qw02l 14 34 arteries artery NNS cord-261058-yu2qw02l 14 35 . . . cord-261058-yu2qw02l 15 1 It -PRON- PRP cord-261058-yu2qw02l 15 2 is be VBZ cord-261058-yu2qw02l 15 3 the the DT cord-261058-yu2qw02l 15 4 predominant predominant JJ cord-261058-yu2qw02l 15 5 cause cause NN cord-261058-yu2qw02l 15 6 of of IN cord-261058-yu2qw02l 15 7 paediatric paediatric JJ cord-261058-yu2qw02l 15 8 acquired acquire VBN cord-261058-yu2qw02l 15 9 heart heart NN cord-261058-yu2qw02l 15 10 disease disease NN cord-261058-yu2qw02l 15 11 in in IN cord-261058-yu2qw02l 15 12 developed develop VBN cord-261058-yu2qw02l 15 13 countries country NNS cord-261058-yu2qw02l 15 14 . . . cord-261058-yu2qw02l 16 1 Despite despite IN cord-261058-yu2qw02l 16 2 40 40 CD cord-261058-yu2qw02l 16 3 years year NNS cord-261058-yu2qw02l 16 4 of of IN cord-261058-yu2qw02l 16 5 research research NN cord-261058-yu2qw02l 16 6 , , , cord-261058-yu2qw02l 16 7 the the DT cord-261058-yu2qw02l 16 8 aetiology aetiology NN cord-261058-yu2qw02l 16 9 of of IN cord-261058-yu2qw02l 16 10 KD KD NNP cord-261058-yu2qw02l 16 11 remains remain VBZ cord-261058-yu2qw02l 16 12 unknown unknown JJ cord-261058-yu2qw02l 16 13 and and CC cord-261058-yu2qw02l 16 14 consequently consequently RB cord-261058-yu2qw02l 16 15 there there EX cord-261058-yu2qw02l 16 16 is be VBZ cord-261058-yu2qw02l 16 17 no no DT cord-261058-yu2qw02l 16 18 diagnostic diagnostic JJ cord-261058-yu2qw02l 16 19 test test NN cord-261058-yu2qw02l 16 20 and and CC cord-261058-yu2qw02l 16 21 treatment treatment NN cord-261058-yu2qw02l 16 22 is be VBZ cord-261058-yu2qw02l 16 23 non non JJ cord-261058-yu2qw02l 16 24 - - JJ cord-261058-yu2qw02l 16 25 specific specific JJ cord-261058-yu2qw02l 16 26 and and CC cord-261058-yu2qw02l 16 27 sub sub JJ cord-261058-yu2qw02l 16 28 - - JJ cord-261058-yu2qw02l 16 29 optimal optimal JJ cord-261058-yu2qw02l 16 30 . . . cord-261058-yu2qw02l 17 1 The the DT cord-261058-yu2qw02l 17 2 consensus consensus NN cord-261058-yu2qw02l 17 3 is be VBZ cord-261058-yu2qw02l 17 4 that that IN cord-261058-yu2qw02l 17 5 KD KD NNP cord-261058-yu2qw02l 17 6 is be VBZ cord-261058-yu2qw02l 17 7 due due JJ cord-261058-yu2qw02l 17 8 to to IN cord-261058-yu2qw02l 17 9 one one CD cord-261058-yu2qw02l 17 10 or or CC cord-261058-yu2qw02l 17 11 more more RBR cord-261058-yu2qw02l 17 12 widely widely RB cord-261058-yu2qw02l 17 13 distributed distribute VBN cord-261058-yu2qw02l 17 14 infectious infectious JJ cord-261058-yu2qw02l 17 15 agent(s agent(s NNP cord-261058-yu2qw02l 17 16 ) ) -RRB- cord-261058-yu2qw02l 17 17 , , , cord-261058-yu2qw02l 17 18 which which WDT cord-261058-yu2qw02l 17 19 evoke evoke VBP cord-261058-yu2qw02l 17 20 an an DT cord-261058-yu2qw02l 17 21 abnormal abnormal JJ cord-261058-yu2qw02l 17 22 immunological immunological JJ cord-261058-yu2qw02l 17 23 response response NN cord-261058-yu2qw02l 17 24 in in IN cord-261058-yu2qw02l 17 25 genetically genetically RB cord-261058-yu2qw02l 17 26 susceptible susceptible JJ cord-261058-yu2qw02l 17 27 individuals individual NNS cord-261058-yu2qw02l 17 28 . . . cord-261058-yu2qw02l 18 1 The the DT cord-261058-yu2qw02l 18 2 epidemiology epidemiology NN cord-261058-yu2qw02l 18 3 of of IN cord-261058-yu2qw02l 18 4 KD KD NNP cord-261058-yu2qw02l 18 5 has have VBZ cord-261058-yu2qw02l 18 6 been be VBN cord-261058-yu2qw02l 18 7 extensively extensively RB cord-261058-yu2qw02l 18 8 investigated investigate VBN cord-261058-yu2qw02l 18 9 in in IN cord-261058-yu2qw02l 18 10 many many JJ cord-261058-yu2qw02l 18 11 populations population NNS cord-261058-yu2qw02l 18 12 and and CC cord-261058-yu2qw02l 18 13 provides provide VBZ cord-261058-yu2qw02l 18 14 much much JJ cord-261058-yu2qw02l 18 15 of of IN cord-261058-yu2qw02l 18 16 the the DT cord-261058-yu2qw02l 18 17 supporting support VBG cord-261058-yu2qw02l 18 18 evidence evidence NN cord-261058-yu2qw02l 18 19 for for IN cord-261058-yu2qw02l 18 20 the the DT cord-261058-yu2qw02l 18 21 consensus consensus NN cord-261058-yu2qw02l 18 22 regarding regard VBG cord-261058-yu2qw02l 18 23 etiology etiology NN cord-261058-yu2qw02l 18 24 . . . cord-261058-yu2qw02l 19 1 These these DT cord-261058-yu2qw02l 19 2 epidemiological epidemiological JJ cord-261058-yu2qw02l 19 3 data datum NNS cord-261058-yu2qw02l 19 4 are be VBP cord-261058-yu2qw02l 19 5 reviewed review VBN cord-261058-yu2qw02l 19 6 here here RB cord-261058-yu2qw02l 19 7 , , , cord-261058-yu2qw02l 19 8 in in IN cord-261058-yu2qw02l 19 9 the the DT cord-261058-yu2qw02l 19 10 context context NN cord-261058-yu2qw02l 19 11 of of IN cord-261058-yu2qw02l 19 12 the the DT cord-261058-yu2qw02l 19 13 etiopathogenesis etiopathogenesis NN cord-261058-yu2qw02l 19 14 . . . cord-261058-yu2qw02l 20 1 It -PRON- PRP cord-261058-yu2qw02l 20 2 is be VBZ cord-261058-yu2qw02l 20 3 suggested suggest VBN cord-261058-yu2qw02l 20 4 that that IN cord-261058-yu2qw02l 20 5 these these DT cord-261058-yu2qw02l 20 6 data datum NNS cord-261058-yu2qw02l 20 7 provide provide VBP cord-261058-yu2qw02l 20 8 additional additional JJ cord-261058-yu2qw02l 20 9 clues clue NNS cord-261058-yu2qw02l 20 10 regarding regard VBG cord-261058-yu2qw02l 20 11 the the DT cord-261058-yu2qw02l 20 12 cause cause NN cord-261058-yu2qw02l 20 13 of of IN cord-261058-yu2qw02l 20 14 KD KD NNP cord-261058-yu2qw02l 20 15 and and CC cord-261058-yu2qw02l 20 16 may may MD cord-261058-yu2qw02l 20 17 account account VB cord-261058-yu2qw02l 20 18 for for IN cord-261058-yu2qw02l 20 19 some some DT cord-261058-yu2qw02l 20 20 of of IN cord-261058-yu2qw02l 20 21 the the DT cord-261058-yu2qw02l 20 22 continuing continue VBG cord-261058-yu2qw02l 20 23 controversies controversy NNS cord-261058-yu2qw02l 20 24 in in IN cord-261058-yu2qw02l 20 25 the the DT cord-261058-yu2qw02l 20 26 field field NN cord-261058-yu2qw02l 20 27 . . . cord-261058-yu2qw02l 21 1 # # $ cord-261058-yu2qw02l 21 2 2005 2005 CD cord-261058-yu2qw02l 21 3 International International NNP cord-261058-yu2qw02l 21 4 Society Society NNP cord-261058-yu2qw02l 21 5 for for IN cord-261058-yu2qw02l 21 6 Infectious Infectious NNP cord-261058-yu2qw02l 21 7 Diseases Diseases NNPS cord-261058-yu2qw02l 21 8 . . . cord-261058-yu2qw02l 22 1 Published publish VBN cord-261058-yu2qw02l 22 2 by by IN cord-261058-yu2qw02l 23 1 Elsevier Elsevier NNP cord-261058-yu2qw02l 23 2 Ltd. Ltd. NNP cord-261058-yu2qw02l 23 3 All all DT cord-261058-yu2qw02l 23 4 rights right NNS cord-261058-yu2qw02l 23 5 reserved reserve VBN cord-261058-yu2qw02l 23 6 . . . cord-261058-yu2qw02l 24 1 no no DT cord-261058-yu2qw02l 24 2 predefined predefined JJ cord-261058-yu2qw02l 24 3 order order NN cord-261058-yu2qw02l 24 4 and and CC cord-261058-yu2qw02l 24 5 some some DT cord-261058-yu2qw02l 24 6 may may MD cord-261058-yu2qw02l 24 7 even even RB cord-261058-yu2qw02l 24 8 be be VB cord-261058-yu2qw02l 24 9 absent absent JJ cord-261058-yu2qw02l 24 10 on on IN cord-261058-yu2qw02l 24 11 presentation presentation NN cord-261058-yu2qw02l 24 12 . . . cord-261058-yu2qw02l 25 1 In in IN cord-261058-yu2qw02l 25 2 many many JJ cord-261058-yu2qw02l 25 3 children child NNS cord-261058-yu2qw02l 25 4 the the DT cord-261058-yu2qw02l 25 5 clinical clinical JJ cord-261058-yu2qw02l 25 6 presentation presentation NN cord-261058-yu2qw02l 25 7 is be VBZ cord-261058-yu2qw02l 25 8 striking strike VBG cord-261058-yu2qw02l 25 9 and and CC cord-261058-yu2qw02l 25 10 KD KD NNP cord-261058-yu2qw02l 25 11 patients patient NNS cord-261058-yu2qw02l 25 12 are be VBP cord-261058-yu2qw02l 25 13 often often RB cord-261058-yu2qw02l 25 14 misdiagnosed misdiagnose VBN cord-261058-yu2qw02l 25 15 with with IN cord-261058-yu2qw02l 25 16 severe severe JJ cord-261058-yu2qw02l 25 17 sepsis sepsis NN cord-261058-yu2qw02l 25 18 . . . cord-261058-yu2qw02l 26 1 However however RB cord-261058-yu2qw02l 26 2 , , , cord-261058-yu2qw02l 26 3 KD KD NNP cord-261058-yu2qw02l 26 4 can can MD cord-261058-yu2qw02l 26 5 have have VB cord-261058-yu2qw02l 26 6 similar similar JJ cord-261058-yu2qw02l 26 7 clinical clinical JJ cord-261058-yu2qw02l 26 8 features feature NNS cord-261058-yu2qw02l 26 9 to to IN cord-261058-yu2qw02l 26 10 other other JJ cord-261058-yu2qw02l 26 11 common common JJ cord-261058-yu2qw02l 26 12 childhood childhood NN cord-261058-yu2qw02l 26 13 illnesses illness NNS cord-261058-yu2qw02l 26 14 , , , cord-261058-yu2qw02l 26 15 such such JJ cord-261058-yu2qw02l 26 16 as as IN cord-261058-yu2qw02l 26 17 measles measle NNS cord-261058-yu2qw02l 26 18 , , , cord-261058-yu2qw02l 26 19 rubella rubella NN cord-261058-yu2qw02l 26 20 and and CC cord-261058-yu2qw02l 26 21 scarlet scarlet JJ cord-261058-yu2qw02l 26 22 fever fever NN cord-261058-yu2qw02l 26 23 . . . cord-261058-yu2qw02l 27 1 These these DT cord-261058-yu2qw02l 27 2 children child NNS cord-261058-yu2qw02l 27 3 may may MD cord-261058-yu2qw02l 27 4 present present VB cord-261058-yu2qw02l 27 5 a a DT cord-261058-yu2qw02l 27 6 diagnostic diagnostic JJ cord-261058-yu2qw02l 27 7 challenge challenge NN cord-261058-yu2qw02l 27 8 6 6 CD cord-261058-yu2qw02l 27 9 and and CC cord-261058-yu2qw02l 27 10 the the DT cord-261058-yu2qw02l 27 11 lack lack NN cord-261058-yu2qw02l 27 12 of of IN cord-261058-yu2qw02l 27 13 a a DT cord-261058-yu2qw02l 27 14 specific specific JJ cord-261058-yu2qw02l 27 15 diagnostic diagnostic JJ cord-261058-yu2qw02l 27 16 test test NN cord-261058-yu2qw02l 27 17 may may MD cord-261058-yu2qw02l 27 18 delay delay VB cord-261058-yu2qw02l 27 19 treatment treatment NN cord-261058-yu2qw02l 27 20 and and CC cord-261058-yu2qw02l 27 21 thus thus RB cord-261058-yu2qw02l 27 22 worsen worsen VB cord-261058-yu2qw02l 27 23 prognosis prognosis NN cord-261058-yu2qw02l 27 24 . . . cord-261058-yu2qw02l 28 1 7 7 CD cord-261058-yu2qw02l 29 1 Moreover moreover RB cord-261058-yu2qw02l 29 2 , , , cord-261058-yu2qw02l 29 3 to to TO cord-261058-yu2qw02l 29 4 confuse confuse VB cord-261058-yu2qw02l 29 5 the the DT cord-261058-yu2qw02l 29 6 clinical clinical JJ cord-261058-yu2qw02l 29 7 picture picture NN cord-261058-yu2qw02l 29 8 further far RBR cord-261058-yu2qw02l 29 9 , , , cord-261058-yu2qw02l 29 10 there there EX cord-261058-yu2qw02l 29 11 is be VBZ cord-261058-yu2qw02l 29 12 increasing increase VBG cord-261058-yu2qw02l 29 13 concern concern NN cord-261058-yu2qw02l 29 14 that that IN cord-261058-yu2qw02l 29 15 the the DT cord-261058-yu2qw02l 29 16 diagnostic diagnostic JJ cord-261058-yu2qw02l 29 17 criteria criterion NNS cord-261058-yu2qw02l 29 18 are be VBP cord-261058-yu2qw02l 29 19 too too RB cord-261058-yu2qw02l 29 20 narrow narrow JJ cord-261058-yu2qw02l 29 21 . . . cord-261058-yu2qw02l 29 22 ' ' '' cord-261058-yu2qw02l 30 1 Atypical atypical JJ cord-261058-yu2qw02l 30 2 ' ' '' cord-261058-yu2qw02l 30 3 or or CC cord-261058-yu2qw02l 30 4 ' ' `` cord-261058-yu2qw02l 30 5 incomplete incomplete JJ cord-261058-yu2qw02l 30 6 ' ' '' cord-261058-yu2qw02l 30 7 KD KD NNP cord-261058-yu2qw02l 30 8 is be VBZ cord-261058-yu2qw02l 30 9 a a DT cord-261058-yu2qw02l 30 10 description description NN cord-261058-yu2qw02l 30 11 used use VBN cord-261058-yu2qw02l 30 12 for for IN cord-261058-yu2qw02l 30 13 children child NNS cord-261058-yu2qw02l 30 14 presenting present VBG cord-261058-yu2qw02l 30 15 with with IN cord-261058-yu2qw02l 30 16 the the DT cord-261058-yu2qw02l 30 17 characteristic characteristic JJ cord-261058-yu2qw02l 30 18 fever fever NN cord-261058-yu2qw02l 30 19 but but CC cord-261058-yu2qw02l 30 20 fewer few JJR cord-261058-yu2qw02l 30 21 than than IN cord-261058-yu2qw02l 30 22 four four CD cord-261058-yu2qw02l 30 23 classical classical JJ cord-261058-yu2qw02l 30 24 signs sign NNS cord-261058-yu2qw02l 30 25 . . . cord-261058-yu2qw02l 31 1 A a DT cord-261058-yu2qw02l 31 2 better well RBR cord-261058-yu2qw02l 31 3 descriptive descriptive JJ cord-261058-yu2qw02l 31 4 term term NN cord-261058-yu2qw02l 31 5 is be VBZ cord-261058-yu2qw02l 31 6 ' ' `` cord-261058-yu2qw02l 31 7 incomplete incomplete JJ cord-261058-yu2qw02l 31 8 KD KD NNP cord-261058-yu2qw02l 31 9 ' ' '' cord-261058-yu2qw02l 31 10 because because IN cord-261058-yu2qw02l 31 11 these these DT cord-261058-yu2qw02l 31 12 children child NNS cord-261058-yu2qw02l 31 13 do do VBP cord-261058-yu2qw02l 31 14 not not RB cord-261058-yu2qw02l 31 15 demonstrate demonstrate VB cord-261058-yu2qw02l 31 16 atypical atypical JJ cord-261058-yu2qw02l 31 17 signs sign NNS cord-261058-yu2qw02l 31 18 , , , cord-261058-yu2qw02l 31 19 just just RB cord-261058-yu2qw02l 31 20 fewer few JJR cord-261058-yu2qw02l 31 21 of of IN cord-261058-yu2qw02l 31 22 them -PRON- PRP cord-261058-yu2qw02l 31 23 . . . cord-261058-yu2qw02l 32 1 Cervical cervical JJ cord-261058-yu2qw02l 32 2 lymphadenopathy lymphadenopathy NN cord-261058-yu2qw02l 32 3 is be VBZ cord-261058-yu2qw02l 32 4 the the DT cord-261058-yu2qw02l 32 5 least least JJS cord-261058-yu2qw02l 32 6 commonly commonly RB cord-261058-yu2qw02l 32 7 observed observe VBN cord-261058-yu2qw02l 32 8 of of IN cord-261058-yu2qw02l 32 9 the the DT cord-261058-yu2qw02l 32 10 diagnostic diagnostic JJ cord-261058-yu2qw02l 32 11 criteria criterion NNS cord-261058-yu2qw02l 32 12 , , , cord-261058-yu2qw02l 32 13 occurring occur VBG cord-261058-yu2qw02l 32 14 in in IN cord-261058-yu2qw02l 32 15 about about RB cord-261058-yu2qw02l 32 16 three three CD cord-261058-yu2qw02l 32 17 quarters quarter NNS cord-261058-yu2qw02l 32 18 of of IN cord-261058-yu2qw02l 32 19 usually usually RB cord-261058-yu2qw02l 32 20 older old JJR cord-261058-yu2qw02l 32 21 children child NNS cord-261058-yu2qw02l 32 22 , , , cord-261058-yu2qw02l 32 23 whilst whilst IN cord-261058-yu2qw02l 32 24 prolonged prolong VBN cord-261058-yu2qw02l 32 25 fever fever NN cord-261058-yu2qw02l 32 26 and and CC cord-261058-yu2qw02l 32 27 peripheral peripheral JJ cord-261058-yu2qw02l 32 28 desquamation desquamation NN cord-261058-yu2qw02l 32 29 have have VBP cord-261058-yu2qw02l 32 30 been be VBN cord-261058-yu2qw02l 32 31 reported report VBN cord-261058-yu2qw02l 32 32 as as IN cord-261058-yu2qw02l 32 33 the the DT cord-261058-yu2qw02l 32 34 commonest common JJS cord-261058-yu2qw02l 32 35 diagnostic diagnostic JJ cord-261058-yu2qw02l 32 36 features feature NNS cord-261058-yu2qw02l 32 37 . . . cord-261058-yu2qw02l 33 1 Incomplete incomplete JJ cord-261058-yu2qw02l 33 2 KD KD NNP cord-261058-yu2qw02l 33 3 may may MD cord-261058-yu2qw02l 33 4 be be VB cord-261058-yu2qw02l 33 5 poorly poorly RB cord-261058-yu2qw02l 33 6 recognised recognise VBN cord-261058-yu2qw02l 33 7 and and CC cord-261058-yu2qw02l 33 8 occurs occur VBZ cord-261058-yu2qw02l 33 9 more more RBR cord-261058-yu2qw02l 33 10 often often RB cord-261058-yu2qw02l 33 11 in in IN cord-261058-yu2qw02l 33 12 infants infant NNS cord-261058-yu2qw02l 33 13 . . . cord-261058-yu2qw02l 34 1 8 8 CD cord-261058-yu2qw02l 34 2 Children child NNS cord-261058-yu2qw02l 34 3 presenting present VBG cord-261058-yu2qw02l 34 4 with with IN cord-261058-yu2qw02l 34 5 incomplete incomplete JJ cord-261058-yu2qw02l 34 6 KD KD NNP cord-261058-yu2qw02l 34 7 are be VBP cord-261058-yu2qw02l 34 8 at at IN cord-261058-yu2qw02l 34 9 higher high JJR cord-261058-yu2qw02l 34 10 risk risk NN cord-261058-yu2qw02l 34 11 of of IN cord-261058-yu2qw02l 34 12 developing develop VBG cord-261058-yu2qw02l 34 13 coronary coronary JJ cord-261058-yu2qw02l 34 14 artery artery NN cord-261058-yu2qw02l 34 15 lesions lesion NNS cord-261058-yu2qw02l 34 16 both both DT cord-261058-yu2qw02l 34 17 because because IN cord-261058-yu2qw02l 34 18 of of IN cord-261058-yu2qw02l 34 19 their -PRON- PRP$ cord-261058-yu2qw02l 34 20 young young JJ cord-261058-yu2qw02l 34 21 age age NN cord-261058-yu2qw02l 34 22 and and CC cord-261058-yu2qw02l 34 23 their -PRON- PRP$ cord-261058-yu2qw02l 34 24 potential potential NN cord-261058-yu2qw02l 34 25 for for IN cord-261058-yu2qw02l 34 26 not not RB cord-261058-yu2qw02l 34 27 receiving receive VBG cord-261058-yu2qw02l 34 28 timely timely JJ cord-261058-yu2qw02l 34 29 immunoglobulin immunoglobulin NN cord-261058-yu2qw02l 34 30 treatment treatment NN cord-261058-yu2qw02l 34 31 . . . cord-261058-yu2qw02l 35 1 8 8 CD cord-261058-yu2qw02l 36 1 Interestingly interestingly RB cord-261058-yu2qw02l 36 2 , , , cord-261058-yu2qw02l 36 3 as as RB cord-261058-yu2qw02l 36 4 many many JJ cord-261058-yu2qw02l 36 5 as as IN cord-261058-yu2qw02l 36 6 10 10 CD cord-261058-yu2qw02l 36 7 % % NN cord-261058-yu2qw02l 36 8 of of IN cord-261058-yu2qw02l 36 9 the the DT cord-261058-yu2qw02l 36 10 children child NNS cord-261058-yu2qw02l 36 11 reported report VBN cord-261058-yu2qw02l 36 12 in in IN cord-261058-yu2qw02l 36 13 the the DT cord-261058-yu2qw02l 36 14 original original JJ cord-261058-yu2qw02l 36 15 report report NN cord-261058-yu2qw02l 36 16 of of IN cord-261058-yu2qw02l 36 17 the the DT cord-261058-yu2qw02l 36 18 syndrome syndrome NN cord-261058-yu2qw02l 36 19 2 2 CD cord-261058-yu2qw02l 36 20 would would MD cord-261058-yu2qw02l 36 21 not not RB cord-261058-yu2qw02l 36 22 fulfil fulfil VB cord-261058-yu2qw02l 36 23 the the DT cord-261058-yu2qw02l 36 24 current current JJ cord-261058-yu2qw02l 36 25 case case NN cord-261058-yu2qw02l 36 26 definition definition NN cord-261058-yu2qw02l 36 27 . . . cord-261058-yu2qw02l 37 1 3 3 LS cord-261058-yu2qw02l 38 1 The the DT cord-261058-yu2qw02l 38 2 clinical clinical JJ cord-261058-yu2qw02l 38 3 diagnostic diagnostic JJ cord-261058-yu2qw02l 38 4 criteria criterion NNS cord-261058-yu2qw02l 38 5 need need VBP cord-261058-yu2qw02l 38 6 refinement refinement NN cord-261058-yu2qw02l 38 7 to to TO cord-261058-yu2qw02l 38 8 increase increase VB cord-261058-yu2qw02l 38 9 their -PRON- PRP$ cord-261058-yu2qw02l 38 10 positive positive JJ cord-261058-yu2qw02l 38 11 predictive predictive JJ cord-261058-yu2qw02l 38 12 value value NN cord-261058-yu2qw02l 38 13 and and CC cord-261058-yu2qw02l 38 14 recent recent JJ cord-261058-yu2qw02l 38 15 guidelines guideline NNS cord-261058-yu2qw02l 38 16 have have VBP cord-261058-yu2qw02l 38 17 been be VBN cord-261058-yu2qw02l 38 18 developed develop VBN cord-261058-yu2qw02l 38 19 in in IN cord-261058-yu2qw02l 38 20 an an DT cord-261058-yu2qw02l 38 21 attempt attempt NN cord-261058-yu2qw02l 38 22 to to TO cord-261058-yu2qw02l 38 23 increase increase VB cord-261058-yu2qw02l 38 24 the the DT cord-261058-yu2qw02l 38 25 sensitivity sensitivity NN cord-261058-yu2qw02l 38 26 of of IN cord-261058-yu2qw02l 38 27 the the DT cord-261058-yu2qw02l 38 28 clinical clinical JJ cord-261058-yu2qw02l 38 29 diagnosis diagnosis NN cord-261058-yu2qw02l 38 30 . . . cord-261058-yu2qw02l 39 1 5 5 LS cord-261058-yu2qw02l 40 1 It -PRON- PRP cord-261058-yu2qw02l 40 2 is be VBZ cord-261058-yu2qw02l 40 3 unclear unclear JJ cord-261058-yu2qw02l 40 4 how how WRB cord-261058-yu2qw02l 40 5 these these DT cord-261058-yu2qw02l 40 6 will will MD cord-261058-yu2qw02l 40 7 perform perform VB cord-261058-yu2qw02l 40 8 in in IN cord-261058-yu2qw02l 40 9 clinical clinical JJ cord-261058-yu2qw02l 40 10 practice practice NN cord-261058-yu2qw02l 40 11 . . . cord-261058-yu2qw02l 41 1 Although although IN cord-261058-yu2qw02l 41 2 these these DT cord-261058-yu2qw02l 41 3 guidelines guideline NNS cord-261058-yu2qw02l 41 4 are be VBP cord-261058-yu2qw02l 41 5 intended intend VBN cord-261058-yu2qw02l 41 6 only only RB cord-261058-yu2qw02l 41 7 as as IN cord-261058-yu2qw02l 41 8 a a DT cord-261058-yu2qw02l 41 9 clinical clinical JJ cord-261058-yu2qw02l 41 10 tool tool NN cord-261058-yu2qw02l 41 11 , , , cord-261058-yu2qw02l 41 12 they -PRON- PRP cord-261058-yu2qw02l 41 13 are be VBP cord-261058-yu2qw02l 41 14 likely likely JJ cord-261058-yu2qw02l 41 15 to to TO cord-261058-yu2qw02l 41 16 have have VB cord-261058-yu2qw02l 41 17 an an DT cord-261058-yu2qw02l 41 18 impact impact NN cord-261058-yu2qw02l 41 19 on on IN cord-261058-yu2qw02l 41 20 the the DT cord-261058-yu2qw02l 41 21 reported reported JJ cord-261058-yu2qw02l 41 22 epidemiology epidemiology NN cord-261058-yu2qw02l 41 23 of of IN cord-261058-yu2qw02l 41 24 KD KD NNP cord-261058-yu2qw02l 41 25 . . . cord-261058-yu2qw02l 42 1 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 42 2 disease disease NN cord-261058-yu2qw02l 42 3 is be VBZ cord-261058-yu2qw02l 42 4 clearly clearly RB cord-261058-yu2qw02l 42 5 not not RB cord-261058-yu2qw02l 42 6 the the DT cord-261058-yu2qw02l 42 7 benign benign JJ cord-261058-yu2qw02l 42 8 childhood childhood NN cord-261058-yu2qw02l 42 9 exanthem exanthem NNP cord-261058-yu2qw02l 42 10 initially initially RB cord-261058-yu2qw02l 42 11 proposed propose VBD cord-261058-yu2qw02l 42 12 1,2 1,2 CD cord-261058-yu2qw02l 42 13 and and CC cord-261058-yu2qw02l 42 14 has have VBZ cord-261058-yu2qw02l 42 15 significant significant JJ cord-261058-yu2qw02l 42 16 long long JJ cord-261058-yu2qw02l 42 17 - - HYPH cord-261058-yu2qw02l 42 18 term term NN cord-261058-yu2qw02l 42 19 implications implication NNS cord-261058-yu2qw02l 42 20 . . . cord-261058-yu2qw02l 43 1 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 43 2 disease disease NN cord-261058-yu2qw02l 43 3 is be VBZ cord-261058-yu2qw02l 43 4 the the DT cord-261058-yu2qw02l 43 5 most most RBS cord-261058-yu2qw02l 43 6 common common JJ cord-261058-yu2qw02l 43 7 cause cause NN cord-261058-yu2qw02l 43 8 of of IN cord-261058-yu2qw02l 43 9 paediatric paediatric JJ cord-261058-yu2qw02l 43 10 acquired acquire VBN cord-261058-yu2qw02l 43 11 heart heart NN cord-261058-yu2qw02l 43 12 disease disease NN cord-261058-yu2qw02l 43 13 in in IN cord-261058-yu2qw02l 43 14 the the DT cord-261058-yu2qw02l 43 15 world world NN cord-261058-yu2qw02l 43 16 . . . cord-261058-yu2qw02l 44 1 3 3 CD cord-261058-yu2qw02l 44 2 Coronary coronary JJ cord-261058-yu2qw02l 44 3 artery artery NN cord-261058-yu2qw02l 44 4 lesions lesion NNS cord-261058-yu2qw02l 44 5 ( ( -LRB- cord-261058-yu2qw02l 44 6 predominantly predominantly RB cord-261058-yu2qw02l 44 7 aneurysms aneurysm NNS cord-261058-yu2qw02l 44 8 ) ) -RRB- cord-261058-yu2qw02l 44 9 occur occur VBP cord-261058-yu2qw02l 44 10 in in IN cord-261058-yu2qw02l 44 11 up up IN cord-261058-yu2qw02l 44 12 to to TO cord-261058-yu2qw02l 44 13 30 30 CD cord-261058-yu2qw02l 44 14 % % NN cord-261058-yu2qw02l 44 15 of of IN cord-261058-yu2qw02l 44 16 untreated untreated JJ cord-261058-yu2qw02l 44 17 and and CC cord-261058-yu2qw02l 44 18 5 5 CD cord-261058-yu2qw02l 44 19 - - SYM cord-261058-yu2qw02l 44 20 10 10 CD cord-261058-yu2qw02l 44 21 % % NN cord-261058-yu2qw02l 44 22 of of IN cord-261058-yu2qw02l 44 23 treated treat VBN cord-261058-yu2qw02l 44 24 children child NNS cord-261058-yu2qw02l 44 25 ; ; . cord-261058-yu2qw02l 45 1 1 1 CD cord-261058-yu2qw02l 45 2 , , , cord-261058-yu2qw02l 45 3 9 9 CD cord-261058-yu2qw02l 45 4 , , , cord-261058-yu2qw02l 45 5 10 10 CD cord-261058-yu2qw02l 45 6 the the DT cord-261058-yu2qw02l 45 7 poor poor JJ cord-261058-yu2qw02l 45 8 outcome outcome NN cord-261058-yu2qw02l 45 9 despite despite IN cord-261058-yu2qw02l 45 10 adequate adequate JJ cord-261058-yu2qw02l 45 11 treatment treatment NN cord-261058-yu2qw02l 45 12 reflects reflect VBZ cord-261058-yu2qw02l 45 13 an an DT cord-261058-yu2qw02l 45 14 incomplete incomplete JJ cord-261058-yu2qw02l 45 15 understanding understanding NN cord-261058-yu2qw02l 45 16 of of IN cord-261058-yu2qw02l 45 17 the the DT cord-261058-yu2qw02l 45 18 etiopathogenesis etiopathogenesis NN cord-261058-yu2qw02l 45 19 . . . cord-261058-yu2qw02l 46 1 Acute acute JJ cord-261058-yu2qw02l 46 2 mortality mortality NN cord-261058-yu2qw02l 46 3 in in IN cord-261058-yu2qw02l 46 4 KD KD NNP cord-261058-yu2qw02l 46 5 is be VBZ cord-261058-yu2qw02l 46 6 increased increase VBN cord-261058-yu2qw02l 46 7 significantly significantly RB cord-261058-yu2qw02l 46 8 , , , cord-261058-yu2qw02l 46 9 with with IN cord-261058-yu2qw02l 46 10 deaths death NNS cord-261058-yu2qw02l 46 11 predominantly predominantly RB cord-261058-yu2qw02l 46 12 occurring occur VBG cord-261058-yu2qw02l 46 13 from from IN cord-261058-yu2qw02l 46 14 myocardial myocardial JJ cord-261058-yu2qw02l 46 15 infarction infarction NN cord-261058-yu2qw02l 46 16 following follow VBG cord-261058-yu2qw02l 46 17 occlusion occlusion NN cord-261058-yu2qw02l 46 18 of of IN cord-261058-yu2qw02l 46 19 giant giant JJ cord-261058-yu2qw02l 46 20 coronary coronary JJ cord-261058-yu2qw02l 46 21 aneurysms aneurysm NNS cord-261058-yu2qw02l 46 22 . . . cord-261058-yu2qw02l 47 1 11 11 CD cord-261058-yu2qw02l 47 2 , , , cord-261058-yu2qw02l 47 3 12 12 CD cord-261058-yu2qw02l 48 1 Overall overall RB cord-261058-yu2qw02l 48 2 , , , cord-261058-yu2qw02l 48 3 myocardial myocardial JJ cord-261058-yu2qw02l 48 4 infarction infarction NN cord-261058-yu2qw02l 48 5 occurs occur VBZ cord-261058-yu2qw02l 48 6 in in IN cord-261058-yu2qw02l 48 7 2 2 CD cord-261058-yu2qw02l 48 8 % % NN cord-261058-yu2qw02l 48 9 of of IN cord-261058-yu2qw02l 48 10 those those DT cord-261058-yu2qw02l 48 11 with with IN cord-261058-yu2qw02l 48 12 coronary coronary JJ cord-261058-yu2qw02l 48 13 artery artery NN cord-261058-yu2qw02l 48 14 lesions lesion NNS cord-261058-yu2qw02l 48 15 . . . cord-261058-yu2qw02l 49 1 13 13 CD cord-261058-yu2qw02l 49 2 Lifelong lifelong JJ cord-261058-yu2qw02l 49 3 medical medical JJ cord-261058-yu2qw02l 49 4 therapy therapy NN cord-261058-yu2qw02l 49 5 , , , cord-261058-yu2qw02l 49 6 coronary coronary JJ cord-261058-yu2qw02l 49 7 artery artery NN cord-261058-yu2qw02l 49 8 grafting grafting NN cord-261058-yu2qw02l 49 9 and and CC cord-261058-yu2qw02l 49 10 even even RB cord-261058-yu2qw02l 49 11 heart heart NN cord-261058-yu2qw02l 49 12 transplantation transplantation NN cord-261058-yu2qw02l 49 13 may may MD cord-261058-yu2qw02l 49 14 be be VB cord-261058-yu2qw02l 49 15 required require VBN cord-261058-yu2qw02l 49 16 . . . cord-261058-yu2qw02l 50 1 1 1 LS cord-261058-yu2qw02l 51 1 Crucially crucially RB cord-261058-yu2qw02l 51 2 , , , cord-261058-yu2qw02l 51 3 in in IN cord-261058-yu2qw02l 51 4 children child NNS cord-261058-yu2qw02l 51 5 without without IN cord-261058-yu2qw02l 51 6 coronary coronary JJ cord-261058-yu2qw02l 51 7 artery artery NN cord-261058-yu2qw02l 51 8 lesions lesion NNS cord-261058-yu2qw02l 51 9 who who WP cord-261058-yu2qw02l 51 10 die die VBP cord-261058-yu2qw02l 51 11 of of IN cord-261058-yu2qw02l 51 12 other other JJ cord-261058-yu2qw02l 51 13 causes cause NNS cord-261058-yu2qw02l 51 14 , , , cord-261058-yu2qw02l 51 15 the the DT cord-261058-yu2qw02l 51 16 coronary coronary JJ cord-261058-yu2qw02l 51 17 arteries artery NNS cord-261058-yu2qw02l 51 18 are be VBP cord-261058-yu2qw02l 51 19 almost almost RB cord-261058-yu2qw02l 51 20 invariably invariably RB cord-261058-yu2qw02l 51 21 markedly markedly RB cord-261058-yu2qw02l 51 22 abnormal abnormal JJ cord-261058-yu2qw02l 51 23 , , , cord-261058-yu2qw02l 51 24 with with IN cord-261058-yu2qw02l 51 25 striking strike VBG cord-261058-yu2qw02l 51 26 pro pro JJ cord-261058-yu2qw02l 51 27 - - JJ cord-261058-yu2qw02l 51 28 atherosclerotic atherosclerotic JJ cord-261058-yu2qw02l 51 29 changes change NNS cord-261058-yu2qw02l 51 30 . . . cord-261058-yu2qw02l 52 1 14 14 CD cord-261058-yu2qw02l 52 2 , , , cord-261058-yu2qw02l 52 3 15 15 CD cord-261058-yu2qw02l 52 4 Abnormal abnormal JJ cord-261058-yu2qw02l 52 5 in in IN cord-261058-yu2qw02l 52 6 vivo vivo NN cord-261058-yu2qw02l 52 7 function function NN cord-261058-yu2qw02l 52 8 in in IN cord-261058-yu2qw02l 52 9 non non JJ cord-261058-yu2qw02l 52 10 - - JJ cord-261058-yu2qw02l 52 11 coronary coronary JJ cord-261058-yu2qw02l 52 12 arteries artery NNS cord-261058-yu2qw02l 53 1 16 16 CD cord-261058-yu2qw02l 53 2 suggests suggest VBZ cord-261058-yu2qw02l 53 3 that that IN cord-261058-yu2qw02l 53 4 cardiovascular cardiovascular JJ cord-261058-yu2qw02l 53 5 damage damage NN cord-261058-yu2qw02l 53 6 post post NN cord-261058-yu2qw02l 53 7 - - NN cord-261058-yu2qw02l 53 8 KD KD NNP cord-261058-yu2qw02l 53 9 is be VBZ cord-261058-yu2qw02l 53 10 both both CC cord-261058-yu2qw02l 53 11 pervasive pervasive JJ cord-261058-yu2qw02l 53 12 and and CC cord-261058-yu2qw02l 53 13 persistent persistent JJ cord-261058-yu2qw02l 53 14 , , , cord-261058-yu2qw02l 53 15 even even RB cord-261058-yu2qw02l 53 16 in in IN cord-261058-yu2qw02l 53 17 the the DT cord-261058-yu2qw02l 53 18 absence absence NN cord-261058-yu2qw02l 53 19 of of IN cord-261058-yu2qw02l 53 20 acute acute JJ cord-261058-yu2qw02l 53 21 coronary coronary JJ cord-261058-yu2qw02l 53 22 artery artery NN cord-261058-yu2qw02l 53 23 lesions lesion NNS cord-261058-yu2qw02l 53 24 . . . cord-261058-yu2qw02l 54 1 Thus thus RB cord-261058-yu2qw02l 54 2 , , , cord-261058-yu2qw02l 54 3 there there EX cord-261058-yu2qw02l 54 4 is be VBZ cord-261058-yu2qw02l 54 5 intense intense JJ cord-261058-yu2qw02l 54 6 speculation speculation NN cord-261058-yu2qw02l 54 7 that that IN cord-261058-yu2qw02l 54 8 KD KD NNP cord-261058-yu2qw02l 54 9 is be VBZ cord-261058-yu2qw02l 54 10 pro pro JJ cord-261058-yu2qw02l 54 11 - - JJ cord-261058-yu2qw02l 54 12 atherosclerotic atherosclerotic JJ cord-261058-yu2qw02l 54 13 , , , cord-261058-yu2qw02l 54 14 but but CC cord-261058-yu2qw02l 54 15 definitive definitive JJ cord-261058-yu2qw02l 54 16 long long JJ cord-261058-yu2qw02l 54 17 - - HYPH cord-261058-yu2qw02l 54 18 term term NN cord-261058-yu2qw02l 54 19 data datum NNS cord-261058-yu2qw02l 54 20 are be VBP cord-261058-yu2qw02l 54 21 lacking lack VBG cord-261058-yu2qw02l 54 22 . . . cord-261058-yu2qw02l 55 1 Regressed regress VBN cord-261058-yu2qw02l 55 2 coronary coronary JJ cord-261058-yu2qw02l 55 3 artery artery NN cord-261058-yu2qw02l 55 4 lesions lesion NNS cord-261058-yu2qw02l 55 5 result result VBP cord-261058-yu2qw02l 55 6 in in IN cord-261058-yu2qw02l 55 7 abnormal abnormal JJ cord-261058-yu2qw02l 55 8 coronary coronary JJ cord-261058-yu2qw02l 55 9 artery artery NN cord-261058-yu2qw02l 55 10 function function NN cord-261058-yu2qw02l 55 11 17 17 CD cord-261058-yu2qw02l 55 12 and and CC cord-261058-yu2qw02l 55 13 histological histological JJ cord-261058-yu2qw02l 55 14 changes change NNS cord-261058-yu2qw02l 55 15 that that WDT cord-261058-yu2qw02l 55 16 are be VBP cord-261058-yu2qw02l 55 17 pro pro JJ cord-261058-yu2qw02l 55 18 - - JJ cord-261058-yu2qw02l 55 19 atherosclerotic atherosclerotic JJ cord-261058-yu2qw02l 55 20 . . . cord-261058-yu2qw02l 56 1 15 15 CD cord-261058-yu2qw02l 56 2 , , , cord-261058-yu2qw02l 56 3 18 18 CD cord-261058-yu2qw02l 57 1 The the DT cord-261058-yu2qw02l 57 2 similarities similarity NNS cord-261058-yu2qw02l 57 3 between between IN cord-261058-yu2qw02l 57 4 KD kd NN cord-261058-yu2qw02l 57 5 and and CC cord-261058-yu2qw02l 57 6 adult adult NN cord-261058-yu2qw02l 57 7 cardiovascular cardiovascular JJ cord-261058-yu2qw02l 57 8 pathology pathology NN cord-261058-yu2qw02l 57 9 suggest suggest VBP cord-261058-yu2qw02l 57 10 that that IN cord-261058-yu2qw02l 57 11 KD KD NNP cord-261058-yu2qw02l 57 12 may may MD cord-261058-yu2qw02l 57 13 be be VB cord-261058-yu2qw02l 57 14 a a DT cord-261058-yu2qw02l 57 15 useful useful JJ cord-261058-yu2qw02l 57 16 paradigm paradigm NN cord-261058-yu2qw02l 57 17 for for IN cord-261058-yu2qw02l 57 18 investigating investigate VBG cord-261058-yu2qw02l 57 19 the the DT cord-261058-yu2qw02l 57 20 etiopathogenesis etiopathogenesis NN cord-261058-yu2qw02l 57 21 of of IN cord-261058-yu2qw02l 57 22 atherosclerosis atherosclerosis NN cord-261058-yu2qw02l 57 23 . . . cord-261058-yu2qw02l 58 1 19 19 CD cord-261058-yu2qw02l 59 1 Does do VBZ cord-261058-yu2qw02l 59 2 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 59 3 disease disease NN cord-261058-yu2qw02l 59 4 represent represent VB cord-261058-yu2qw02l 59 5 an an DT cord-261058-yu2qw02l 59 6 extreme extreme JJ cord-261058-yu2qw02l 59 7 phenotype phenotype NN cord-261058-yu2qw02l 59 8 of of IN cord-261058-yu2qw02l 59 9 a a DT cord-261058-yu2qw02l 59 10 more more RBR cord-261058-yu2qw02l 59 11 pervasive pervasive JJ cord-261058-yu2qw02l 59 12 phenomenon phenomenon NN cord-261058-yu2qw02l 59 13 ? ? . cord-261058-yu2qw02l 60 1 It -PRON- PRP cord-261058-yu2qw02l 60 2 is be VBZ cord-261058-yu2qw02l 60 3 possible possible JJ cord-261058-yu2qw02l 60 4 that that IN cord-261058-yu2qw02l 60 5 KD KD NNP cord-261058-yu2qw02l 60 6 is be VBZ cord-261058-yu2qw02l 60 7 not not RB cord-261058-yu2qw02l 60 8 a a DT cord-261058-yu2qw02l 60 9 distinct distinct JJ cord-261058-yu2qw02l 60 10 entity entity NN cord-261058-yu2qw02l 60 11 , , , cord-261058-yu2qw02l 60 12 but but CC cord-261058-yu2qw02l 60 13 the the DT cord-261058-yu2qw02l 60 14 more more RBR cord-261058-yu2qw02l 60 15 clinically clinically RB cord-261058-yu2qw02l 60 16 obvious obvious JJ cord-261058-yu2qw02l 60 17 end end NN cord-261058-yu2qw02l 60 18 of of IN cord-261058-yu2qw02l 60 19 a a DT cord-261058-yu2qw02l 60 20 spectrum spectrum NN cord-261058-yu2qw02l 60 21 of of IN cord-261058-yu2qw02l 60 22 pathogenic pathogenic JJ cord-261058-yu2qw02l 60 23 processes process NNS cord-261058-yu2qw02l 60 24 . . . cord-261058-yu2qw02l 61 1 KD KD NNP cord-261058-yu2qw02l 61 2 may may MD cord-261058-yu2qw02l 61 3 therefore therefore RB cord-261058-yu2qw02l 61 4 reflect reflect VB cord-261058-yu2qw02l 61 5 an an DT cord-261058-yu2qw02l 61 6 extreme extreme JJ cord-261058-yu2qw02l 61 7 clinical clinical JJ cord-261058-yu2qw02l 61 8 phenotype phenotype NN cord-261058-yu2qw02l 61 9 where where WRB cord-261058-yu2qw02l 61 10 childhood childhood NN cord-261058-yu2qw02l 61 11 infections infection NNS cord-261058-yu2qw02l 61 12 predispose predispose VBP cord-261058-yu2qw02l 61 13 to to IN cord-261058-yu2qw02l 61 14 subsequent subsequent JJ cord-261058-yu2qw02l 61 15 endothelial endothelial JJ cord-261058-yu2qw02l 61 16 damage damage NN cord-261058-yu2qw02l 61 17 and and CC cord-261058-yu2qw02l 61 18 cardiovascular cardiovascular JJ cord-261058-yu2qw02l 61 19 pathology pathology NN cord-261058-yu2qw02l 61 20 . . . cord-261058-yu2qw02l 62 1 Thus thus RB cord-261058-yu2qw02l 62 2 in in IN cord-261058-yu2qw02l 62 3 genetically genetically RB cord-261058-yu2qw02l 62 4 susceptible susceptible JJ cord-261058-yu2qw02l 62 5 children child NNS cord-261058-yu2qw02l 62 6 , , , cord-261058-yu2qw02l 62 7 acute acute JJ cord-261058-yu2qw02l 62 8 infections infection NNS cord-261058-yu2qw02l 62 9 such such JJ cord-261058-yu2qw02l 62 10 as as IN cord-261058-yu2qw02l 62 11 those those DT cord-261058-yu2qw02l 62 12 causing cause VBG cord-261058-yu2qw02l 62 13 fever fever NN cord-261058-yu2qw02l 62 14 and and CC cord-261058-yu2qw02l 62 15 rash rash NN cord-261058-yu2qw02l 62 16 , , , cord-261058-yu2qw02l 62 17 may may MD cord-261058-yu2qw02l 62 18 result result VB cord-261058-yu2qw02l 62 19 in in IN cord-261058-yu2qw02l 62 20 unrecognised unrecognised JJ cord-261058-yu2qw02l 62 21 damage damage NN cord-261058-yu2qw02l 62 22 to to IN cord-261058-yu2qw02l 62 23 the the DT cord-261058-yu2qw02l 62 24 cardiovascular cardiovascular JJ cord-261058-yu2qw02l 62 25 system system NN cord-261058-yu2qw02l 62 26 that that WDT cord-261058-yu2qw02l 62 27 later later RB cord-261058-yu2qw02l 62 28 manifests manifest VBZ cord-261058-yu2qw02l 62 29 itself -PRON- PRP cord-261058-yu2qw02l 62 30 as as IN cord-261058-yu2qw02l 62 31 adult adult NN cord-261058-yu2qw02l 62 32 cardiovascular cardiovascular JJ cord-261058-yu2qw02l 62 33 disease disease NN cord-261058-yu2qw02l 62 34 . . . cord-261058-yu2qw02l 63 1 Adult adult JJ cord-261058-yu2qw02l 63 2 atherosclerotic atherosclerotic JJ cord-261058-yu2qw02l 63 3 disease disease NN cord-261058-yu2qw02l 63 4 ( ( -LRB- cord-261058-yu2qw02l 63 5 like like IN cord-261058-yu2qw02l 63 6 KD KD NNP cord-261058-yu2qw02l 63 7 ) ) -RRB- cord-261058-yu2qw02l 63 8 has have VBZ cord-261058-yu2qw02l 63 9 not not RB cord-261058-yu2qw02l 63 10 been be VBN cord-261058-yu2qw02l 63 11 reliably reliably RB cord-261058-yu2qw02l 63 12 associated associate VBN cord-261058-yu2qw02l 63 13 with with IN cord-261058-yu2qw02l 63 14 a a DT cord-261058-yu2qw02l 63 15 single single JJ cord-261058-yu2qw02l 63 16 infectious infectious JJ cord-261058-yu2qw02l 63 17 etiology etiology NN cord-261058-yu2qw02l 63 18 , , , cord-261058-yu2qw02l 63 19 but but CC cord-261058-yu2qw02l 63 20 correlates correlate VBZ cord-261058-yu2qw02l 63 21 with with IN cord-261058-yu2qw02l 63 22 overall overall JJ cord-261058-yu2qw02l 63 23 infectious infectious JJ cord-261058-yu2qw02l 63 24 burden burden NN cord-261058-yu2qw02l 63 25 . . . cord-261058-yu2qw02l 64 1 20 20 CD cord-261058-yu2qw02l 65 1 Furthermore furthermore RB cord-261058-yu2qw02l 65 2 , , , cord-261058-yu2qw02l 65 3 acute acute JJ cord-261058-yu2qw02l 65 4 childhood childhood NN cord-261058-yu2qw02l 65 5 infections infection NNS cord-261058-yu2qw02l 65 6 are be VBP cord-261058-yu2qw02l 65 7 accompanied accompany VBN cord-261058-yu2qw02l 65 8 by by IN cord-261058-yu2qw02l 65 9 pro pro JJ cord-261058-yu2qw02l 65 10 - - JJ cord-261058-yu2qw02l 65 11 atherosclerotic atherosclerotic JJ cord-261058-yu2qw02l 65 12 phenomena phenomenon NNS cord-261058-yu2qw02l 65 13 and and CC cord-261058-yu2qw02l 65 14 subsequent subsequent JJ cord-261058-yu2qw02l 65 15 thickening thickening NN cord-261058-yu2qw02l 65 16 of of IN cord-261058-yu2qw02l 65 17 the the DT cord-261058-yu2qw02l 65 18 arterial arterial JJ cord-261058-yu2qw02l 65 19 intima intima NN cord-261058-yu2qw02l 65 20 . . . cord-261058-yu2qw02l 66 1 21 21 CD cord-261058-yu2qw02l 67 1 Understanding understand VBG cord-261058-yu2qw02l 67 2 the the DT cord-261058-yu2qw02l 67 3 etiopathogenesis etiopathogenesis NN cord-261058-yu2qw02l 67 4 of of IN cord-261058-yu2qw02l 67 5 KD KD NNP cord-261058-yu2qw02l 67 6 may may MD cord-261058-yu2qw02l 67 7 therefore therefore RB cord-261058-yu2qw02l 67 8 identify identify VB cord-261058-yu2qw02l 67 9 common common JJ cord-261058-yu2qw02l 67 10 gene gene NN cord-261058-yu2qw02l 67 11 - - HYPH cord-261058-yu2qw02l 67 12 environment environment NN cord-261058-yu2qw02l 67 13 interactions interaction NNS cord-261058-yu2qw02l 67 14 that that WDT cord-261058-yu2qw02l 67 15 are be VBP cord-261058-yu2qw02l 67 16 involved involve VBN cord-261058-yu2qw02l 67 17 in in IN cord-261058-yu2qw02l 67 18 adult adult NN cord-261058-yu2qw02l 67 19 cardiovascular cardiovascular JJ cord-261058-yu2qw02l 67 20 disease disease NN cord-261058-yu2qw02l 67 21 . . . cord-261058-yu2qw02l 68 1 Why why WRB cord-261058-yu2qw02l 68 2 is be VBZ cord-261058-yu2qw02l 68 3 it -PRON- PRP cord-261058-yu2qw02l 68 4 important important JJ cord-261058-yu2qw02l 68 5 to to TO cord-261058-yu2qw02l 68 6 understand understand VB cord-261058-yu2qw02l 68 7 the the DT cord-261058-yu2qw02l 68 8 etiology etiology NN cord-261058-yu2qw02l 68 9 and and CC cord-261058-yu2qw02l 68 10 pathogenesis pathogenesis NN cord-261058-yu2qw02l 68 11 of of IN cord-261058-yu2qw02l 68 12 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 68 13 disease disease NN cord-261058-yu2qw02l 68 14 ? ? . cord-261058-yu2qw02l 69 1 The the DT cord-261058-yu2qw02l 69 2 timely timely JJ cord-261058-yu2qw02l 69 3 diagnosis diagnosis NN cord-261058-yu2qw02l 69 4 of of IN cord-261058-yu2qw02l 69 5 KD KD NNP cord-261058-yu2qw02l 69 6 is be VBZ cord-261058-yu2qw02l 69 7 essential essential JJ cord-261058-yu2qw02l 69 8 in in IN cord-261058-yu2qw02l 69 9 maximising maximise VBG cord-261058-yu2qw02l 69 10 the the DT cord-261058-yu2qw02l 69 11 prevention prevention NN cord-261058-yu2qw02l 69 12 of of IN cord-261058-yu2qw02l 69 13 overt overt JJ cord-261058-yu2qw02l 69 14 coronary coronary JJ cord-261058-yu2qw02l 69 15 damage damage NN cord-261058-yu2qw02l 69 16 ; ; : cord-261058-yu2qw02l 69 17 treatment treatment NN cord-261058-yu2qw02l 69 18 beyond beyond IN cord-261058-yu2qw02l 69 19 ten ten CD cord-261058-yu2qw02l 69 20 days day NNS cord-261058-yu2qw02l 69 21 of of IN cord-261058-yu2qw02l 69 22 onset onset NN cord-261058-yu2qw02l 69 23 is be VBZ cord-261058-yu2qw02l 69 24 associated associate VBN cord-261058-yu2qw02l 69 25 with with IN cord-261058-yu2qw02l 69 26 a a DT cord-261058-yu2qw02l 69 27 worse bad JJR cord-261058-yu2qw02l 69 28 outcome outcome NN cord-261058-yu2qw02l 69 29 and and CC cord-261058-yu2qw02l 69 30 an an DT cord-261058-yu2qw02l 69 31 increased increase VBN cord-261058-yu2qw02l 69 32 incidence incidence NN cord-261058-yu2qw02l 69 33 of of IN cord-261058-yu2qw02l 69 34 coronary coronary JJ cord-261058-yu2qw02l 69 35 abnormalities abnormality NNS cord-261058-yu2qw02l 69 36 . . . cord-261058-yu2qw02l 70 1 22 22 CD cord-261058-yu2qw02l 70 2 , , , cord-261058-yu2qw02l 70 3 23 23 CD cord-261058-yu2qw02l 71 1 The the DT cord-261058-yu2qw02l 71 2 lack lack NN cord-261058-yu2qw02l 71 3 of of IN cord-261058-yu2qw02l 71 4 a a DT cord-261058-yu2qw02l 71 5 specific specific JJ cord-261058-yu2qw02l 71 6 diagnostic diagnostic JJ cord-261058-yu2qw02l 71 7 test test NN cord-261058-yu2qw02l 71 8 and and CC cord-261058-yu2qw02l 71 9 the the DT cord-261058-yu2qw02l 71 10 limited limited JJ cord-261058-yu2qw02l 71 11 clinical clinical JJ cord-261058-yu2qw02l 71 12 utility utility NN cord-261058-yu2qw02l 71 13 of of IN cord-261058-yu2qw02l 71 14 the the DT cord-261058-yu2qw02l 71 15 current current JJ cord-261058-yu2qw02l 71 16 clinical clinical JJ cord-261058-yu2qw02l 71 17 diagnostic diagnostic JJ cord-261058-yu2qw02l 71 18 criteria criterion NNS cord-261058-yu2qw02l 71 19 mean mean VBP cord-261058-yu2qw02l 71 20 that that IN cord-261058-yu2qw02l 71 21 the the DT cord-261058-yu2qw02l 71 22 diagnosis diagnosis NN cord-261058-yu2qw02l 71 23 is be VBZ cord-261058-yu2qw02l 71 24 often often RB cord-261058-yu2qw02l 71 25 delayed delay VBN cord-261058-yu2qw02l 71 26 , , , cord-261058-yu2qw02l 71 27 even even RB cord-261058-yu2qw02l 71 28 in in IN cord-261058-yu2qw02l 71 29 populations population NNS cord-261058-yu2qw02l 71 30 where where WRB cord-261058-yu2qw02l 71 31 the the DT cord-261058-yu2qw02l 71 32 condition condition NN cord-261058-yu2qw02l 71 33 is be VBZ cord-261058-yu2qw02l 71 34 well well RB cord-261058-yu2qw02l 71 35 recognised recognise VBN cord-261058-yu2qw02l 71 36 . . . cord-261058-yu2qw02l 72 1 24 24 CD cord-261058-yu2qw02l 73 1 The the DT cord-261058-yu2qw02l 73 2 currently currently RB cord-261058-yu2qw02l 73 3 accepted accept VBN cord-261058-yu2qw02l 73 4 best good JJS cord-261058-yu2qw02l 73 5 treatment treatment NN cord-261058-yu2qw02l 73 6 ( ( -LRB- cord-261058-yu2qw02l 73 7 intravenous intravenous JJ cord-261058-yu2qw02l 73 8 immunoglobulin immunoglobulin NN cord-261058-yu2qw02l 73 9 and and CC cord-261058-yu2qw02l 73 10 aspirin aspirin NN cord-261058-yu2qw02l 73 11 ( ( -LRB- cord-261058-yu2qw02l 73 12 Table Table NNP cord-261058-yu2qw02l 73 13 2 2 CD cord-261058-yu2qw02l 73 14 ) ) -RRB- cord-261058-yu2qw02l 73 15 6 6 CD cord-261058-yu2qw02l 73 16 fails fail VBZ cord-261058-yu2qw02l 73 17 to to TO cord-261058-yu2qw02l 73 18 prevent prevent VB cord-261058-yu2qw02l 73 19 coronary coronary JJ cord-261058-yu2qw02l 73 20 artery artery NN cord-261058-yu2qw02l 73 21 abnormalities abnormality NNS cord-261058-yu2qw02l 73 22 ( ( -LRB- cord-261058-yu2qw02l 73 23 identifiable identifiable JJ cord-261058-yu2qw02l 73 24 by by IN cord-261058-yu2qw02l 73 25 imaging image VBG cord-261058-yu2qw02l 73 26 ) ) -RRB- cord-261058-yu2qw02l 73 27 in in IN cord-261058-yu2qw02l 73 28 up up IN cord-261058-yu2qw02l 73 29 to to TO cord-261058-yu2qw02l 73 30 10 10 CD cord-261058-yu2qw02l 73 31 % % NN cord-261058-yu2qw02l 73 32 of of IN cord-261058-yu2qw02l 73 33 cases case NNS cord-261058-yu2qw02l 73 34 . . . cord-261058-yu2qw02l 74 1 25 25 CD cord-261058-yu2qw02l 74 2 Specific specific JJ cord-261058-yu2qw02l 74 3 diagnostic diagnostic JJ cord-261058-yu2qw02l 74 4 test(s test(s NN cord-261058-yu2qw02l 74 5 ) ) -RRB- cord-261058-yu2qw02l 74 6 and and CC cord-261058-yu2qw02l 74 7 rational rational JJ cord-261058-yu2qw02l 74 8 interventions intervention NNS cord-261058-yu2qw02l 74 9 could could MD cord-261058-yu2qw02l 74 10 be be VB cord-261058-yu2qw02l 74 11 readily readily RB cord-261058-yu2qw02l 74 12 developed develop VBN cord-261058-yu2qw02l 74 13 if if IN cord-261058-yu2qw02l 74 14 the the DT cord-261058-yu2qw02l 74 15 etiopathogenesis etiopathogenesis NN cord-261058-yu2qw02l 74 16 of of IN cord-261058-yu2qw02l 74 17 KD KD NNP cord-261058-yu2qw02l 74 18 was be VBD cord-261058-yu2qw02l 74 19 fully fully RB cord-261058-yu2qw02l 74 20 understood understand VBN cord-261058-yu2qw02l 74 21 . . . cord-261058-yu2qw02l 75 1 Moreover moreover RB cord-261058-yu2qw02l 75 2 , , , cord-261058-yu2qw02l 75 3 preventative preventative JJ cord-261058-yu2qw02l 75 4 treatments treatment NNS cord-261058-yu2qw02l 75 5 such such JJ cord-261058-yu2qw02l 75 6 as as IN cord-261058-yu2qw02l 75 7 vaccines vaccine NNS cord-261058-yu2qw02l 75 8 would would MD cord-261058-yu2qw02l 75 9 be be VB cord-261058-yu2qw02l 75 10 justified justify VBN cord-261058-yu2qw02l 75 11 in in IN cord-261058-yu2qw02l 75 12 populations population NNS cord-261058-yu2qw02l 75 13 with with IN cord-261058-yu2qw02l 75 14 the the DT cord-261058-yu2qw02l 75 15 highest high JJS cord-261058-yu2qw02l 75 16 KD KD NNP cord-261058-yu2qw02l 75 17 incidence incidence NN cord-261058-yu2qw02l 75 18 , , , cord-261058-yu2qw02l 75 19 where where WRB cord-261058-yu2qw02l 75 20 KD KD NNP cord-261058-yu2qw02l 75 21 affects affect VBZ cord-261058-yu2qw02l 75 22 1 1 CD cord-261058-yu2qw02l 75 23 - - SYM cord-261058-yu2qw02l 75 24 2 2 CD cord-261058-yu2qw02l 75 25 % % NN cord-261058-yu2qw02l 75 26 of of IN cord-261058-yu2qw02l 75 27 all all DT cord-261058-yu2qw02l 75 28 children child NNS cord-261058-yu2qw02l 75 29 , , , cord-261058-yu2qw02l 75 30 such such JJ cord-261058-yu2qw02l 75 31 as as IN cord-261058-yu2qw02l 75 32 Korea Korea NNP cord-261058-yu2qw02l 75 33 and and CC cord-261058-yu2qw02l 75 34 Japan Japan NNP cord-261058-yu2qw02l 75 35 . . . cord-261058-yu2qw02l 76 1 3 3 LS cord-261058-yu2qw02l 77 1 The the DT cord-261058-yu2qw02l 77 2 consensus consensus NN cord-261058-yu2qw02l 77 3 view view NN cord-261058-yu2qw02l 77 4 is be VBZ cord-261058-yu2qw02l 77 5 that that IN cord-261058-yu2qw02l 77 6 KD KD NNP cord-261058-yu2qw02l 77 7 results result VBZ cord-261058-yu2qw02l 77 8 from from IN cord-261058-yu2qw02l 77 9 a a DT cord-261058-yu2qw02l 77 10 widely widely RB cord-261058-yu2qw02l 77 11 distributed distribute VBN cord-261058-yu2qw02l 77 12 infectious infectious JJ cord-261058-yu2qw02l 77 13 agent agent NN cord-261058-yu2qw02l 77 14 ( ( -LRB- cord-261058-yu2qw02l 77 15 or or CC cord-261058-yu2qw02l 77 16 possibly possibly RB cord-261058-yu2qw02l 77 17 agents agent NNS cord-261058-yu2qw02l 77 18 ) ) -RRB- cord-261058-yu2qw02l 77 19 that that WDT cord-261058-yu2qw02l 77 20 causes cause VBZ cord-261058-yu2qw02l 77 21 the the DT cord-261058-yu2qw02l 77 22 clinical clinical JJ cord-261058-yu2qw02l 77 23 syndrome syndrome NN cord-261058-yu2qw02l 77 24 in in IN cord-261058-yu2qw02l 77 25 genetically genetically RB cord-261058-yu2qw02l 77 26 susceptible susceptible JJ cord-261058-yu2qw02l 77 27 children child NNS cord-261058-yu2qw02l 77 28 . . . cord-261058-yu2qw02l 78 1 Much much JJ cord-261058-yu2qw02l 78 2 of of IN cord-261058-yu2qw02l 78 3 the the DT cord-261058-yu2qw02l 78 4 supporting support VBG cord-261058-yu2qw02l 78 5 data datum NNS cord-261058-yu2qw02l 78 6 for for IN cord-261058-yu2qw02l 78 7 this this DT cord-261058-yu2qw02l 78 8 viewpoint viewpoint NN cord-261058-yu2qw02l 78 9 is be VBZ cord-261058-yu2qw02l 78 10 provided provide VBN cord-261058-yu2qw02l 78 11 by by IN cord-261058-yu2qw02l 78 12 epidemiological epidemiological JJ cord-261058-yu2qw02l 78 13 studies study NNS cord-261058-yu2qw02l 78 14 in in IN cord-261058-yu2qw02l 78 15 a a DT cord-261058-yu2qw02l 78 16 variety variety NN cord-261058-yu2qw02l 78 17 of of IN cord-261058-yu2qw02l 78 18 populations population NNS cord-261058-yu2qw02l 78 19 . . . cord-261058-yu2qw02l 79 1 KD KD NNP cord-261058-yu2qw02l 79 2 is be VBZ cord-261058-yu2qw02l 79 3 described describe VBN cord-261058-yu2qw02l 79 4 in in IN cord-261058-yu2qw02l 79 5 all all DT cord-261058-yu2qw02l 79 6 ethnic ethnic JJ cord-261058-yu2qw02l 79 7 groups group NNS cord-261058-yu2qw02l 79 8 , , , cord-261058-yu2qw02l 79 9 but but CC cord-261058-yu2qw02l 79 10 the the DT cord-261058-yu2qw02l 79 11 incidence incidence NN cord-261058-yu2qw02l 79 12 varies vary VBZ cord-261058-yu2qw02l 79 13 dramatically dramatically RB cord-261058-yu2qw02l 79 14 ( ( -LRB- cord-261058-yu2qw02l 79 15 see see VB cord-261058-yu2qw02l 79 16 below below RB cord-261058-yu2qw02l 79 17 ) ) -RRB- cord-261058-yu2qw02l 79 18 . . . cord-261058-yu2qw02l 80 1 The the DT cord-261058-yu2qw02l 80 2 homogeneity homogeneity NN cord-261058-yu2qw02l 80 3 of of IN cord-261058-yu2qw02l 80 4 the the DT cord-261058-yu2qw02l 80 5 clinical clinical JJ cord-261058-yu2qw02l 80 6 phenotype phenotype NN cord-261058-yu2qw02l 80 7 and and CC cord-261058-yu2qw02l 80 8 epidemiology epidemiology NN cord-261058-yu2qw02l 80 9 suggest suggest VBP cord-261058-yu2qw02l 80 10 that that IN cord-261058-yu2qw02l 80 11 KD KD NNP cord-261058-yu2qw02l 80 12 arises arise VBZ cord-261058-yu2qw02l 80 13 from from IN cord-261058-yu2qw02l 80 14 common common JJ cord-261058-yu2qw02l 80 15 disease disease NN cord-261058-yu2qw02l 80 16 processes process NNS cord-261058-yu2qw02l 80 17 , , , cord-261058-yu2qw02l 80 18 although although IN cord-261058-yu2qw02l 80 19 the the DT cord-261058-yu2qw02l 80 20 antigenic antigenic JJ cord-261058-yu2qw02l 80 21 trigger(s trigger(s NN cord-261058-yu2qw02l 80 22 ) ) -RRB- cord-261058-yu2qw02l 80 23 and/or and/or CC cord-261058-yu2qw02l 80 24 the the DT cord-261058-yu2qw02l 80 25 genetic genetic JJ cord-261058-yu2qw02l 80 26 determinants determinant NNS cord-261058-yu2qw02l 80 27 may may MD cord-261058-yu2qw02l 80 28 differ differ VB cord-261058-yu2qw02l 80 29 between between IN cord-261058-yu2qw02l 80 30 populations population NNS cord-261058-yu2qw02l 80 31 . . . cord-261058-yu2qw02l 81 1 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 81 2 disease disease NN cord-261058-yu2qw02l 81 3 shows show VBZ cord-261058-yu2qw02l 81 4 a a DT cord-261058-yu2qw02l 81 5 striking striking JJ cord-261058-yu2qw02l 81 6 age age NN cord-261058-yu2qw02l 81 7 distribution distribution NN cord-261058-yu2qw02l 81 8 reminiscent reminiscent JJ cord-261058-yu2qw02l 81 9 of of IN cord-261058-yu2qw02l 81 10 other other JJ cord-261058-yu2qw02l 81 11 childhood childhood NN cord-261058-yu2qw02l 81 12 infections infection NNS cord-261058-yu2qw02l 81 13 . . . cord-261058-yu2qw02l 82 1 Over over IN cord-261058-yu2qw02l 82 2 80 80 CD cord-261058-yu2qw02l 82 3 % % NN cord-261058-yu2qw02l 82 4 of of IN cord-261058-yu2qw02l 82 5 cases case NNS cord-261058-yu2qw02l 82 6 occur occur VBP cord-261058-yu2qw02l 82 7 between between IN cord-261058-yu2qw02l 82 8 the the DT cord-261058-yu2qw02l 82 9 ages age NNS cord-261058-yu2qw02l 82 10 of of IN cord-261058-yu2qw02l 82 11 six six CD cord-261058-yu2qw02l 82 12 months month NNS cord-261058-yu2qw02l 82 13 and and CC cord-261058-yu2qw02l 82 14 four four CD cord-261058-yu2qw02l 82 15 years year NNS cord-261058-yu2qw02l 82 16 , , , cord-261058-yu2qw02l 82 17 26 26 CD cord-261058-yu2qw02l 82 18 although although IN cord-261058-yu2qw02l 82 19 the the DT cord-261058-yu2qw02l 82 20 condition condition NN cord-261058-yu2qw02l 82 21 occurs occur VBZ cord-261058-yu2qw02l 82 22 rarely rarely RB cord-261058-yu2qw02l 82 23 both both DT cord-261058-yu2qw02l 82 24 earlier early JJR cord-261058-yu2qw02l 82 25 27 27 CD cord-261058-yu2qw02l 82 26 and and CC cord-261058-yu2qw02l 82 27 later later RB cord-261058-yu2qw02l 82 28 28 28 CD cord-261058-yu2qw02l 82 29 in in IN cord-261058-yu2qw02l 82 30 life life NN cord-261058-yu2qw02l 82 31 . . . cord-261058-yu2qw02l 83 1 The the DT cord-261058-yu2qw02l 83 2 low low JJ cord-261058-yu2qw02l 83 3 incidence incidence NN cord-261058-yu2qw02l 83 4 of of IN cord-261058-yu2qw02l 83 5 KD KD NNP cord-261058-yu2qw02l 83 6 in in IN cord-261058-yu2qw02l 83 7 both both CC cord-261058-yu2qw02l 83 8 the the DT cord-261058-yu2qw02l 83 9 first first JJ cord-261058-yu2qw02l 83 10 six six CD cord-261058-yu2qw02l 83 11 months month NNS cord-261058-yu2qw02l 83 12 suggests suggest VBZ cord-261058-yu2qw02l 83 13 that that IN cord-261058-yu2qw02l 83 14 most most JJS cord-261058-yu2qw02l 83 15 infants infant NNS cord-261058-yu2qw02l 83 16 are be VBP cord-261058-yu2qw02l 83 17 protected protect VBN cord-261058-yu2qw02l 83 18 by by IN cord-261058-yu2qw02l 83 19 passively passively RB cord-261058-yu2qw02l 83 20 acquired acquire VBN cord-261058-yu2qw02l 83 21 maternal maternal JJ cord-261058-yu2qw02l 83 22 antibody antibody NN cord-261058-yu2qw02l 83 23 against against IN cord-261058-yu2qw02l 83 24 the the DT cord-261058-yu2qw02l 83 25 causative causative JJ cord-261058-yu2qw02l 83 26 agent(s agent(s NNP cord-261058-yu2qw02l 83 27 ) ) -RRB- cord-261058-yu2qw02l 83 28 . . . cord-261058-yu2qw02l 84 1 A a DT cord-261058-yu2qw02l 84 2 transient transient JJ cord-261058-yu2qw02l 84 3 immunological immunological JJ cord-261058-yu2qw02l 84 4 immaturity immaturity NN cord-261058-yu2qw02l 84 5 may may MD cord-261058-yu2qw02l 84 6 also also RB cord-261058-yu2qw02l 84 7 account account VB cord-261058-yu2qw02l 84 8 for for IN cord-261058-yu2qw02l 84 9 the the DT cord-261058-yu2qw02l 84 10 low low JJ cord-261058-yu2qw02l 84 11 incidence incidence NN cord-261058-yu2qw02l 84 12 in in IN cord-261058-yu2qw02l 84 13 the the DT cord-261058-yu2qw02l 84 14 first first JJ cord-261058-yu2qw02l 84 15 few few JJ cord-261058-yu2qw02l 84 16 months month NNS cord-261058-yu2qw02l 84 17 postnatally postnatally RB cord-261058-yu2qw02l 84 18 . . . cord-261058-yu2qw02l 85 1 29 29 CD cord-261058-yu2qw02l 86 1 The the DT cord-261058-yu2qw02l 86 2 low low JJ cord-261058-yu2qw02l 86 3 incidence incidence NN cord-261058-yu2qw02l 86 4 of of IN cord-261058-yu2qw02l 86 5 KD KD NNP cord-261058-yu2qw02l 86 6 beyond beyond IN cord-261058-yu2qw02l 86 7 mid mid NN cord-261058-yu2qw02l 86 8 - - NN cord-261058-yu2qw02l 86 9 childhood childhood NN cord-261058-yu2qw02l 86 10 suggest suggest VBP cord-261058-yu2qw02l 86 11 a a DT cord-261058-yu2qw02l 86 12 ubiquitous ubiquitous JJ cord-261058-yu2qw02l 86 13 antigen(s antigen(s NNP cord-261058-yu2qw02l 86 14 ) ) -RRB- cord-261058-yu2qw02l 87 1 that that IN cord-261058-yu2qw02l 87 2 most most JJS cord-261058-yu2qw02l 87 3 children child NNS cord-261058-yu2qw02l 87 4 encounter encounter VBP cord-261058-yu2qw02l 87 5 uneventfully uneventfully RB cord-261058-yu2qw02l 87 6 in in IN cord-261058-yu2qw02l 87 7 early early JJ cord-261058-yu2qw02l 87 8 childhood childhood NN cord-261058-yu2qw02l 87 9 and and CC cord-261058-yu2qw02l 88 1 to to TO cord-261058-yu2qw02l 88 2 which which WDT cord-261058-yu2qw02l 88 3 they -PRON- PRP cord-261058-yu2qw02l 88 4 mount mount VBP cord-261058-yu2qw02l 88 5 an an DT cord-261058-yu2qw02l 88 6 appropriate appropriate JJ cord-261058-yu2qw02l 88 7 and and CC cord-261058-yu2qw02l 88 8 protective protective JJ cord-261058-yu2qw02l 88 9 immune immune JJ cord-261058-yu2qw02l 88 10 response response NN cord-261058-yu2qw02l 88 11 . . . cord-261058-yu2qw02l 89 1 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 89 2 disease disease NN cord-261058-yu2qw02l 89 3 is be VBZ cord-261058-yu2qw02l 89 4 more more RBR cord-261058-yu2qw02l 89 5 common common JJ cord-261058-yu2qw02l 89 6 in in IN cord-261058-yu2qw02l 89 7 boys boy NNS cord-261058-yu2qw02l 89 8 ( ( -LRB- cord-261058-yu2qw02l 89 9 male male JJ cord-261058-yu2qw02l 89 10 : : : cord-261058-yu2qw02l 89 11 female female JJ cord-261058-yu2qw02l 89 12 ratio ratio NN cord-261058-yu2qw02l 89 13 1.6:1 1.6:1 CD cord-261058-yu2qw02l 89 14 ) ) -RRB- cord-261058-yu2qw02l 89 15 1 1 CD cord-261058-yu2qw02l 89 16 a a DT cord-261058-yu2qw02l 89 17 feature feature NN cord-261058-yu2qw02l 89 18 observed observe VBN cord-261058-yu2qw02l 89 19 in in IN cord-261058-yu2qw02l 89 20 many many JJ cord-261058-yu2qw02l 89 21 infectious infectious JJ cord-261058-yu2qw02l 89 22 diseases disease NNS cord-261058-yu2qw02l 89 23 30 30 CD cord-261058-yu2qw02l 89 24 , , , cord-261058-yu2qw02l 89 25 31 31 CD cord-261058-yu2qw02l 89 26 and and CC cord-261058-yu2qw02l 89 27 also also RB cord-261058-yu2qw02l 89 28 in in IN cord-261058-yu2qw02l 89 29 coronary coronary JJ cord-261058-yu2qw02l 89 30 atherosclerosis atherosclerosis NN cord-261058-yu2qw02l 89 31 , , , cord-261058-yu2qw02l 89 32 where where WRB cord-261058-yu2qw02l 89 33 sex sex NN cord-261058-yu2qw02l 89 34 differences difference NNS cord-261058-yu2qw02l 89 35 in in IN cord-261058-yu2qw02l 89 36 immune immune JJ cord-261058-yu2qw02l 89 37 responses response NNS cord-261058-yu2qw02l 89 38 are be VBP cord-261058-yu2qw02l 89 39 suggested suggest VBN cord-261058-yu2qw02l 89 40 to to TO cord-261058-yu2qw02l 89 41 mediate mediate VB cord-261058-yu2qw02l 89 42 susceptibility susceptibility NN cord-261058-yu2qw02l 89 43 . . . cord-261058-yu2qw02l 90 1 32 32 CD cord-261058-yu2qw02l 90 2 Seasonal seasonal JJ cord-261058-yu2qw02l 90 3 variation variation NN cord-261058-yu2qw02l 90 4 in in IN cord-261058-yu2qw02l 90 5 KD KD NNP cord-261058-yu2qw02l 90 6 incidence incidence NN cord-261058-yu2qw02l 90 7 is be VBZ cord-261058-yu2qw02l 90 8 well well RB cord-261058-yu2qw02l 90 9 recognised recognise VBN cord-261058-yu2qw02l 90 10 , , , cord-261058-yu2qw02l 90 11 but but CC cord-261058-yu2qw02l 90 12 the the DT cord-261058-yu2qw02l 90 13 predominant predominant JJ cord-261058-yu2qw02l 90 14 season season NN cord-261058-yu2qw02l 90 15 varies vary VBZ cord-261058-yu2qw02l 90 16 in in IN cord-261058-yu2qw02l 90 17 different different JJ cord-261058-yu2qw02l 90 18 countries country NNS cord-261058-yu2qw02l 90 19 . . . cord-261058-yu2qw02l 91 1 In in IN cord-261058-yu2qw02l 91 2 the the DT cord-261058-yu2qw02l 91 3 UK UK NNP cord-261058-yu2qw02l 91 4 , , , cord-261058-yu2qw02l 91 5 33 33 CD cord-261058-yu2qw02l 91 6 Australia Australia NNP cord-261058-yu2qw02l 91 7 24 24 CD cord-261058-yu2qw02l 91 8 and and CC cord-261058-yu2qw02l 91 9 the the DT cord-261058-yu2qw02l 91 10 USA USA NNP cord-261058-yu2qw02l 91 11 34,35 34,35 CD cord-261058-yu2qw02l 91 12 KD KD NNP cord-261058-yu2qw02l 91 13 is be VBZ cord-261058-yu2qw02l 91 14 most most RBS cord-261058-yu2qw02l 91 15 common common JJ cord-261058-yu2qw02l 91 16 in in IN cord-261058-yu2qw02l 91 17 winter winter NN cord-261058-yu2qw02l 91 18 and and CC cord-261058-yu2qw02l 91 19 spring spring NN cord-261058-yu2qw02l 91 20 . . . cord-261058-yu2qw02l 92 1 In in IN cord-261058-yu2qw02l 92 2 China China NNP cord-261058-yu2qw02l 92 3 , , , cord-261058-yu2qw02l 92 4 spring spring NN cord-261058-yu2qw02l 92 5 and and CC cord-261058-yu2qw02l 92 6 summer summer NN cord-261058-yu2qw02l 92 7 predominate predominate VBP cord-261058-yu2qw02l 92 8 36 36 CD cord-261058-yu2qw02l 92 9 and and CC cord-261058-yu2qw02l 92 10 in in IN cord-261058-yu2qw02l 92 11 Korea Korea NNP cord-261058-yu2qw02l 92 12 KD KD NNP cord-261058-yu2qw02l 92 13 incidence incidence NN cord-261058-yu2qw02l 92 14 is be VBZ cord-261058-yu2qw02l 92 15 highest high JJS cord-261058-yu2qw02l 92 16 in in IN cord-261058-yu2qw02l 92 17 summer summer NN cord-261058-yu2qw02l 92 18 months month NNS cord-261058-yu2qw02l 92 19 . . . cord-261058-yu2qw02l 93 1 37 37 CD cord-261058-yu2qw02l 94 1 In in IN cord-261058-yu2qw02l 94 2 Japan Japan NNP cord-261058-yu2qw02l 94 3 , , , cord-261058-yu2qw02l 94 4 which which WDT cord-261058-yu2qw02l 94 5 reports report VBZ cord-261058-yu2qw02l 94 6 the the DT cord-261058-yu2qw02l 94 7 highest high JJS cord-261058-yu2qw02l 94 8 KD KD NNP cord-261058-yu2qw02l 94 9 incidence incidence NN cord-261058-yu2qw02l 94 10 , , , cord-261058-yu2qw02l 94 11 Table Table NNP cord-261058-yu2qw02l 94 12 2 2 CD cord-261058-yu2qw02l 94 13 Treatment Treatment NNP cord-261058-yu2qw02l 94 14 of of IN cord-261058-yu2qw02l 94 15 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 94 16 disease disease NN cord-261058-yu2qw02l 94 17 ( ( -LRB- cord-261058-yu2qw02l 94 18 for for IN cord-261058-yu2qw02l 94 19 detailed detailed JJ cord-261058-yu2qw02l 94 20 discussion discussion NN cord-261058-yu2qw02l 94 21 of of IN cord-261058-yu2qw02l 94 22 the the DT cord-261058-yu2qw02l 94 23 treatment treatment NN cord-261058-yu2qw02l 94 24 of of IN cord-261058-yu2qw02l 94 25 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 94 26 disease disease NN cord-261058-yu2qw02l 94 27 see see VBP cord-261058-yu2qw02l 94 28 references reference NNS cord-261058-yu2qw02l 94 29 5,6,97 5,6,97 VBG cord-261058-yu2qw02l 94 30 ) ) -RRB- cord-261058-yu2qw02l 94 31 . . . cord-261058-yu2qw02l 95 1 At at IN cord-261058-yu2qw02l 95 2 a a DT cord-261058-yu2qw02l 95 3 dose dose NN cord-261058-yu2qw02l 95 4 of of IN cord-261058-yu2qw02l 95 5 2 2 CD cord-261058-yu2qw02l 95 6 g g NN cord-261058-yu2qw02l 95 7 / / SYM cord-261058-yu2qw02l 95 8 kg kg NN cord-261058-yu2qw02l 95 9 given give VBN cord-261058-yu2qw02l 95 10 as as IN cord-261058-yu2qw02l 95 11 a a DT cord-261058-yu2qw02l 95 12 single single JJ cord-261058-yu2qw02l 95 13 infusion infusion NN cord-261058-yu2qw02l 95 14 over over IN cord-261058-yu2qw02l 95 15 10 10 CD cord-261058-yu2qw02l 95 16 - - SYM cord-261058-yu2qw02l 95 17 12 12 CD cord-261058-yu2qw02l 95 18 hours hour NNS cord-261058-yu2qw02l 95 19 ( ( -LRB- cord-261058-yu2qw02l 95 20 unless unless IN cord-261058-yu2qw02l 95 21 cardiac cardiac JJ cord-261058-yu2qw02l 95 22 status status NN cord-261058-yu2qw02l 95 23 necessitates necessitate VBZ cord-261058-yu2qw02l 95 24 infusing infuse VBG cord-261058-yu2qw02l 95 25 the the DT cord-261058-yu2qw02l 95 26 dose dose NN cord-261058-yu2qw02l 95 27 more more RBR cord-261058-yu2qw02l 95 28 slowly slowly RB cord-261058-yu2qw02l 95 29 or or CC cord-261058-yu2qw02l 95 30 in in IN cord-261058-yu2qw02l 95 31 divided divide VBN cord-261058-yu2qw02l 95 32 doses dose NNS cord-261058-yu2qw02l 95 33 ) ) -RRB- cord-261058-yu2qw02l 95 34 . . . cord-261058-yu2qw02l 96 1 Failure failure NN cord-261058-yu2qw02l 96 2 to to TO cord-261058-yu2qw02l 96 3 respond respond VB cord-261058-yu2qw02l 96 4 to to IN cord-261058-yu2qw02l 96 5 this this DT cord-261058-yu2qw02l 96 6 initial initial JJ cord-261058-yu2qw02l 96 7 IVIG IVIG NNP cord-261058-yu2qw02l 96 8 dose dose NN cord-261058-yu2qw02l 96 9 is be VBZ cord-261058-yu2qw02l 96 10 usually usually RB cord-261058-yu2qw02l 96 11 treated treat VBN cord-261058-yu2qw02l 96 12 with with IN cord-261058-yu2qw02l 96 13 a a DT cord-261058-yu2qw02l 96 14 second second JJ cord-261058-yu2qw02l 96 15 dose dose NN cord-261058-yu2qw02l 96 16 ( ( -LRB- cord-261058-yu2qw02l 96 17 usually usually RB cord-261058-yu2qw02l 96 18 2 2 CD cord-261058-yu2qw02l 96 19 g g NN cord-261058-yu2qw02l 96 20 / / SYM cord-261058-yu2qw02l 96 21 kg kg NN cord-261058-yu2qw02l 96 22 as as IN cord-261058-yu2qw02l 96 23 a a DT cord-261058-yu2qw02l 96 24 single single JJ cord-261058-yu2qw02l 96 25 infusion infusion NN cord-261058-yu2qw02l 96 26 ) ) -RRB- cord-261058-yu2qw02l 96 27 . . . cord-261058-yu2qw02l 97 1 Failure failure NN cord-261058-yu2qw02l 97 2 to to TO cord-261058-yu2qw02l 97 3 respond respond VB cord-261058-yu2qw02l 97 4 to to IN cord-261058-yu2qw02l 97 5 the the DT cord-261058-yu2qw02l 97 6 second second JJ cord-261058-yu2qw02l 97 7 IVIG IVIG NNP cord-261058-yu2qw02l 97 8 dose dose NN cord-261058-yu2qw02l 97 9 is be VBZ cord-261058-yu2qw02l 97 10 often often RB cord-261058-yu2qw02l 97 11 treated treat VBN cord-261058-yu2qw02l 97 12 with with IN cord-261058-yu2qw02l 97 13 intravenous intravenous JJ cord-261058-yu2qw02l 97 14 methylprednisolone methylprednisolone NN cord-261058-yu2qw02l 97 15 under under IN cord-261058-yu2qw02l 97 16 expert expert JJ cord-261058-yu2qw02l 97 17 supervision supervision NN cord-261058-yu2qw02l 98 1 The the DT cord-261058-yu2qw02l 98 2 dose dose NN cord-261058-yu2qw02l 98 3 of of IN cord-261058-yu2qw02l 98 4 aspirin aspirin NN cord-261058-yu2qw02l 98 5 is be VBZ cord-261058-yu2qw02l 98 6 controversial controversial JJ cord-261058-yu2qw02l 98 7 and and CC cord-261058-yu2qw02l 98 8 its -PRON- PRP$ cord-261058-yu2qw02l 98 9 utility utility NN cord-261058-yu2qw02l 98 10 has have VBZ cord-261058-yu2qw02l 98 11 never never RB cord-261058-yu2qw02l 98 12 been be VBN cord-261058-yu2qw02l 98 13 proven prove VBN cord-261058-yu2qw02l 98 14 in in IN cord-261058-yu2qw02l 98 15 a a DT cord-261058-yu2qw02l 98 16 randomised randomised JJ cord-261058-yu2qw02l 98 17 controlled control VBN cord-261058-yu2qw02l 98 18 trial trial NN cord-261058-yu2qw02l 98 19 . . . cord-261058-yu2qw02l 99 1 It -PRON- PRP cord-261058-yu2qw02l 99 2 remains remain VBZ cord-261058-yu2qw02l 99 3 , , , cord-261058-yu2qw02l 99 4 however however RB cord-261058-yu2qw02l 99 5 , , , cord-261058-yu2qw02l 99 6 part part NN cord-261058-yu2qw02l 99 7 of of IN cord-261058-yu2qw02l 99 8 the the DT cord-261058-yu2qw02l 99 9 standard standard JJ cord-261058-yu2qw02l 99 10 management management NN cord-261058-yu2qw02l 99 11 of of IN cord-261058-yu2qw02l 99 12 KD KD NNP cord-261058-yu2qw02l 99 13 . . . cord-261058-yu2qw02l 100 1 Generally generally RB cord-261058-yu2qw02l 100 2 ' ' `` cord-261058-yu2qw02l 100 3 high high JJ cord-261058-yu2qw02l 100 4 dose dose NN cord-261058-yu2qw02l 100 5 ' ' '' cord-261058-yu2qw02l 100 6 aspirin aspirin NN cord-261058-yu2qw02l 100 7 ( ( -LRB- cord-261058-yu2qw02l 100 8 50 50 CD cord-261058-yu2qw02l 100 9 - - SYM cord-261058-yu2qw02l 100 10 100 100 CD cord-261058-yu2qw02l 100 11 mg mg NNP cord-261058-yu2qw02l 100 12 / / SYM cord-261058-yu2qw02l 100 13 kg kg NNP cord-261058-yu2qw02l 100 14 / / SYM cord-261058-yu2qw02l 100 15 day day NN cord-261058-yu2qw02l 100 16 in in IN cord-261058-yu2qw02l 100 17 divided divide VBN cord-261058-yu2qw02l 100 18 doses dose NNS cord-261058-yu2qw02l 100 19 ) ) -RRB- cord-261058-yu2qw02l 100 20 is be VBZ cord-261058-yu2qw02l 100 21 given give VBN cord-261058-yu2qw02l 100 22 acutely acutely RB cord-261058-yu2qw02l 100 23 until until IN cord-261058-yu2qw02l 100 24 the the DT cord-261058-yu2qw02l 100 25 fever fever NN cord-261058-yu2qw02l 100 26 defervesces defervesce NNS cord-261058-yu2qw02l 100 27 , , , cord-261058-yu2qw02l 100 28 when when WRB cord-261058-yu2qw02l 100 29 ' ' `` cord-261058-yu2qw02l 100 30 low low JJ cord-261058-yu2qw02l 100 31 dose dose NN cord-261058-yu2qw02l 100 32 ' ' '' cord-261058-yu2qw02l 100 33 aspirin aspirin NN cord-261058-yu2qw02l 100 34 ( ( -LRB- cord-261058-yu2qw02l 100 35 2 2 CD cord-261058-yu2qw02l 100 36 - - SYM cord-261058-yu2qw02l 100 37 5 5 CD cord-261058-yu2qw02l 100 38 mg mg NNP cord-261058-yu2qw02l 100 39 / / SYM cord-261058-yu2qw02l 100 40 kg kg NNP cord-261058-yu2qw02l 100 41 / / SYM cord-261058-yu2qw02l 100 42 day day NN cord-261058-yu2qw02l 100 43 ) ) -RRB- cord-261058-yu2qw02l 100 44 is be VBZ cord-261058-yu2qw02l 100 45 given give VBN cord-261058-yu2qw02l 100 46 until until IN cord-261058-yu2qw02l 100 47 an an DT cord-261058-yu2qw02l 100 48 echocardiogram echocardiogram NN cord-261058-yu2qw02l 100 49 at at IN cord-261058-yu2qw02l 100 50 six six CD cord-261058-yu2qw02l 100 51 weeks week NNS cord-261058-yu2qw02l 100 52 after after IN cord-261058-yu2qw02l 100 53 the the DT cord-261058-yu2qw02l 100 54 KD KD NNP cord-261058-yu2qw02l 100 55 diagnosis diagnosis NN cord-261058-yu2qw02l 100 56 is be VBZ cord-261058-yu2qw02l 100 57 normal normal JJ cord-261058-yu2qw02l 100 58 . . . cord-261058-yu2qw02l 101 1 If if IN cord-261058-yu2qw02l 101 2 the the DT cord-261058-yu2qw02l 101 3 six six CD cord-261058-yu2qw02l 101 4 week week NN cord-261058-yu2qw02l 101 5 echocardiogram echocardiogram NN cord-261058-yu2qw02l 101 6 is be VBZ cord-261058-yu2qw02l 101 7 abnormal abnormal JJ cord-261058-yu2qw02l 101 8 , , , cord-261058-yu2qw02l 101 9 aspirin aspirin NN cord-261058-yu2qw02l 101 10 is be VBZ cord-261058-yu2qw02l 101 11 usually usually RB cord-261058-yu2qw02l 101 12 continued continue VBN cord-261058-yu2qw02l 101 13 under under IN cord-261058-yu2qw02l 101 14 cardiological cardiological JJ cord-261058-yu2qw02l 101 15 supervision supervision NN cord-261058-yu2qw02l 101 16 Anti anti JJ cord-261058-yu2qw02l 101 17 - - JJ cord-261058-yu2qw02l 101 18 cytokine cytokine JJ cord-261058-yu2qw02l 101 19 therapies therapy NNS cord-261058-yu2qw02l 101 20 and and CC cord-261058-yu2qw02l 101 21 other other JJ cord-261058-yu2qw02l 101 22 interventions intervention NNS cord-261058-yu2qw02l 101 23 are be VBP cord-261058-yu2qw02l 101 24 generally generally RB cord-261058-yu2qw02l 101 25 unproven unproven JJ cord-261058-yu2qw02l 101 26 but but CC cord-261058-yu2qw02l 101 27 have have VBP cord-261058-yu2qw02l 101 28 occasionally occasionally RB cord-261058-yu2qw02l 101 29 been be VBN cord-261058-yu2qw02l 101 30 used use VBN cord-261058-yu2qw02l 101 31 . . . cord-261058-yu2qw02l 102 1 For for IN cord-261058-yu2qw02l 102 2 a a DT cord-261058-yu2qw02l 102 3 review review NN cord-261058-yu2qw02l 102 4 see see VB cord-261058-yu2qw02l 102 5 Newburger Newburger NNP cord-261058-yu2qw02l 102 6 and and CC cord-261058-yu2qw02l 102 7 Fullton Fullton NNP cord-261058-yu2qw02l 102 8 5 5 CD cord-261058-yu2qw02l 102 9 the the DT cord-261058-yu2qw02l 102 10 seasonal seasonal JJ cord-261058-yu2qw02l 102 11 variation variation NN cord-261058-yu2qw02l 102 12 is be VBZ cord-261058-yu2qw02l 102 13 less less RBR cord-261058-yu2qw02l 102 14 marked marked JJ cord-261058-yu2qw02l 102 15 . . . cord-261058-yu2qw02l 103 1 38 38 CD cord-261058-yu2qw02l 104 1 One one CD cord-261058-yu2qw02l 104 2 possible possible JJ cord-261058-yu2qw02l 104 3 explanation explanation NN cord-261058-yu2qw02l 104 4 for for IN cord-261058-yu2qw02l 104 5 these these DT cord-261058-yu2qw02l 104 6 divergent divergent JJ cord-261058-yu2qw02l 104 7 data datum NNS cord-261058-yu2qw02l 104 8 is be VBZ cord-261058-yu2qw02l 104 9 that that DT cord-261058-yu2qw02l 104 10 season season NN cord-261058-yu2qw02l 104 11 is be VBZ cord-261058-yu2qw02l 104 12 a a DT cord-261058-yu2qw02l 104 13 marker marker NN cord-261058-yu2qw02l 104 14 for for IN cord-261058-yu2qw02l 104 15 weather weather NN cord-261058-yu2qw02l 104 16 conditions condition NNS cord-261058-yu2qw02l 104 17 that that WDT cord-261058-yu2qw02l 104 18 have have VBP cord-261058-yu2qw02l 104 19 a a DT cord-261058-yu2qw02l 104 20 more more RBR cord-261058-yu2qw02l 104 21 direct direct JJ cord-261058-yu2qw02l 104 22 role role NN cord-261058-yu2qw02l 104 23 in in IN cord-261058-yu2qw02l 104 24 determining determine VBG cord-261058-yu2qw02l 104 25 the the DT cord-261058-yu2qw02l 104 26 incidence incidence NN cord-261058-yu2qw02l 104 27 . . . cord-261058-yu2qw02l 105 1 In in IN cord-261058-yu2qw02l 105 2 the the DT cord-261058-yu2qw02l 105 3 US US NNP cord-261058-yu2qw02l 105 4 , , , cord-261058-yu2qw02l 105 5 KD KD NNP cord-261058-yu2qw02l 105 6 incidence incidence NN cord-261058-yu2qw02l 105 7 clearly clearly RB cord-261058-yu2qw02l 105 8 correlates correlate VBZ cord-261058-yu2qw02l 105 9 negatively negatively RB cord-261058-yu2qw02l 105 10 with with IN cord-261058-yu2qw02l 105 11 average average JJ cord-261058-yu2qw02l 105 12 ambient ambient JJ cord-261058-yu2qw02l 105 13 temperature temperature NN cord-261058-yu2qw02l 105 14 and and CC cord-261058-yu2qw02l 105 15 positively positively RB cord-261058-yu2qw02l 105 16 with with IN cord-261058-yu2qw02l 105 17 average average JJ cord-261058-yu2qw02l 105 18 rainfall rainfall NN cord-261058-yu2qw02l 105 19 in in IN cord-261058-yu2qw02l 105 20 the the DT cord-261058-yu2qw02l 105 21 preceding precede VBG cord-261058-yu2qw02l 105 22 month month NN cord-261058-yu2qw02l 105 23 . . . cord-261058-yu2qw02l 106 1 39 39 CD cord-261058-yu2qw02l 106 2 Studies study NNS cord-261058-yu2qw02l 106 3 are be VBP cord-261058-yu2qw02l 106 4 underway underway RB cord-261058-yu2qw02l 106 5 investigating investigate VBG cord-261058-yu2qw02l 106 6 similar similar JJ cord-261058-yu2qw02l 106 7 parameters parameter NNS cord-261058-yu2qw02l 106 8 in in IN cord-261058-yu2qw02l 106 9 the the DT cord-261058-yu2qw02l 106 10 UK UK NNP cord-261058-yu2qw02l 106 11 . . . cord-261058-yu2qw02l 107 1 It -PRON- PRP cord-261058-yu2qw02l 107 2 is be VBZ cord-261058-yu2qw02l 107 3 unknown unknown JJ cord-261058-yu2qw02l 107 4 whether whether IN cord-261058-yu2qw02l 107 5 the the DT cord-261058-yu2qw02l 107 6 meteorological meteorological JJ cord-261058-yu2qw02l 107 7 conditions condition NNS cord-261058-yu2qw02l 107 8 themselves -PRON- PRP cord-261058-yu2qw02l 107 9 predispose predispose VBP cord-261058-yu2qw02l 107 10 to to IN cord-261058-yu2qw02l 107 11 KD KD NNP cord-261058-yu2qw02l 107 12 , , , cord-261058-yu2qw02l 107 13 or or CC cord-261058-yu2qw02l 107 14 , , , cord-261058-yu2qw02l 107 15 more more RBR cord-261058-yu2qw02l 107 16 plausibly plausibly RB cord-261058-yu2qw02l 107 17 , , , cord-261058-yu2qw02l 107 18 if if IN cord-261058-yu2qw02l 107 19 they -PRON- PRP cord-261058-yu2qw02l 107 20 alter alter VBP cord-261058-yu2qw02l 107 21 the the DT cord-261058-yu2qw02l 107 22 epidemiology epidemiology NN cord-261058-yu2qw02l 107 23 of of IN cord-261058-yu2qw02l 107 24 etiological etiological JJ cord-261058-yu2qw02l 107 25 agents agent NNS cord-261058-yu2qw02l 107 26 . . . cord-261058-yu2qw02l 108 1 The the DT cord-261058-yu2qw02l 108 2 lack lack NN cord-261058-yu2qw02l 108 3 of of IN cord-261058-yu2qw02l 108 4 consistent consistent JJ cord-261058-yu2qw02l 108 5 seasonal seasonal JJ cord-261058-yu2qw02l 108 6 associations association NNS cord-261058-yu2qw02l 108 7 in in IN cord-261058-yu2qw02l 108 8 different different JJ cord-261058-yu2qw02l 108 9 countries country NNS cord-261058-yu2qw02l 108 10 raises raise VBZ cord-261058-yu2qw02l 108 11 the the DT cord-261058-yu2qw02l 108 12 possibility possibility NN cord-261058-yu2qw02l 108 13 that that IN cord-261058-yu2qw02l 108 14 various various JJ cord-261058-yu2qw02l 108 15 etiological etiological JJ cord-261058-yu2qw02l 108 16 agents agent NNS cord-261058-yu2qw02l 108 17 may may MD cord-261058-yu2qw02l 108 18 be be VB cord-261058-yu2qw02l 108 19 involved involve VBN cord-261058-yu2qw02l 108 20 in in IN cord-261058-yu2qw02l 108 21 the the DT cord-261058-yu2qw02l 108 22 etiology etiology NN cord-261058-yu2qw02l 108 23 of of IN cord-261058-yu2qw02l 108 24 KD KD NNP cord-261058-yu2qw02l 108 25 . . . cord-261058-yu2qw02l 109 1 Geographical geographical JJ cord-261058-yu2qw02l 109 2 clustering clustering NN cord-261058-yu2qw02l 109 3 of of IN cord-261058-yu2qw02l 109 4 KD KD NNP cord-261058-yu2qw02l 109 5 cases case NNS cord-261058-yu2qw02l 109 6 and and CC cord-261058-yu2qw02l 109 7 epidemics epidemic NNS cord-261058-yu2qw02l 109 8 have have VBP cord-261058-yu2qw02l 109 9 been be VBN cord-261058-yu2qw02l 109 10 reported report VBN cord-261058-yu2qw02l 109 11 from from IN cord-261058-yu2qw02l 109 12 a a DT cord-261058-yu2qw02l 109 13 number number NN cord-261058-yu2qw02l 109 14 of of IN cord-261058-yu2qw02l 109 15 countries country NNS cord-261058-yu2qw02l 109 16 , , , cord-261058-yu2qw02l 109 17 40 40 CD cord-261058-yu2qw02l 109 18 - - SYM cord-261058-yu2qw02l 109 19 44 44 CD cord-261058-yu2qw02l 109 20 although although IN cord-261058-yu2qw02l 109 21 they -PRON- PRP cord-261058-yu2qw02l 109 22 have have VBP cord-261058-yu2qw02l 109 23 been be VBN cord-261058-yu2qw02l 109 24 much much RB cord-261058-yu2qw02l 109 25 less less RBR cord-261058-yu2qw02l 109 26 frequently frequently RB cord-261058-yu2qw02l 109 27 reported report VBN cord-261058-yu2qw02l 109 28 in in IN cord-261058-yu2qw02l 109 29 the the DT cord-261058-yu2qw02l 109 30 past past JJ cord-261058-yu2qw02l 109 31 decade decade NN cord-261058-yu2qw02l 109 32 , , , cord-261058-yu2qw02l 109 33 possibly possibly RB cord-261058-yu2qw02l 109 34 suggesting suggest VBG cord-261058-yu2qw02l 109 35 a a DT cord-261058-yu2qw02l 109 36 changing change VBG cord-261058-yu2qw02l 109 37 epidemiology epidemiology NN cord-261058-yu2qw02l 109 38 . . . cord-261058-yu2qw02l 110 1 In in IN cord-261058-yu2qw02l 110 2 Japan Japan NNP cord-261058-yu2qw02l 110 3 , , , cord-261058-yu2qw02l 110 4 which which WDT cord-261058-yu2qw02l 110 5 has have VBZ cord-261058-yu2qw02l 110 6 provided provide VBN cord-261058-yu2qw02l 110 7 the the DT cord-261058-yu2qw02l 110 8 most most RBS cord-261058-yu2qw02l 110 9 comprehensive comprehensive JJ cord-261058-yu2qw02l 110 10 epidemiological epidemiological JJ cord-261058-yu2qw02l 110 11 data datum NNS cord-261058-yu2qw02l 110 12 , , , cord-261058-yu2qw02l 110 13 epidemics epidemic NNS cord-261058-yu2qw02l 110 14 of of IN cord-261058-yu2qw02l 110 15 KD KD NNP cord-261058-yu2qw02l 110 16 have have VBP cord-261058-yu2qw02l 110 17 been be VBN cord-261058-yu2qw02l 110 18 described describe VBN cord-261058-yu2qw02l 110 19 with with IN cord-261058-yu2qw02l 110 20 a a DT cord-261058-yu2qw02l 110 21 clear clear JJ cord-261058-yu2qw02l 110 22 epicentre epicentre NN cord-261058-yu2qw02l 110 23 and and CC cord-261058-yu2qw02l 110 24 documented document VBD cord-261058-yu2qw02l 110 25 geographical geographical JJ cord-261058-yu2qw02l 110 26 spread spread NN cord-261058-yu2qw02l 110 27 across across IN cord-261058-yu2qw02l 110 28 the the DT cord-261058-yu2qw02l 110 29 whole whole JJ cord-261058-yu2qw02l 110 30 nation nation NN cord-261058-yu2qw02l 110 31 within within IN cord-261058-yu2qw02l 110 32 six six CD cord-261058-yu2qw02l 110 33 months month NNS cord-261058-yu2qw02l 110 34 . . . cord-261058-yu2qw02l 111 1 42 42 CD cord-261058-yu2qw02l 112 1 These these DT cord-261058-yu2qw02l 112 2 epidemiological epidemiological JJ cord-261058-yu2qw02l 112 3 data datum NNS cord-261058-yu2qw02l 112 4 clearly clearly RB cord-261058-yu2qw02l 112 5 indicate indicate VBP cord-261058-yu2qw02l 112 6 an an DT cord-261058-yu2qw02l 112 7 infectious infectious JJ cord-261058-yu2qw02l 112 8 etiology etiology NN cord-261058-yu2qw02l 112 9 for for IN cord-261058-yu2qw02l 112 10 KD KD NNP cord-261058-yu2qw02l 112 11 . . . cord-261058-yu2qw02l 113 1 The the DT cord-261058-yu2qw02l 113 2 clinical clinical JJ cord-261058-yu2qw02l 113 3 features feature NNS cord-261058-yu2qw02l 113 4 of of IN cord-261058-yu2qw02l 113 5 the the DT cord-261058-yu2qw02l 113 6 disease disease NN cord-261058-yu2qw02l 113 7 are be VBP cord-261058-yu2qw02l 113 8 also also RB cord-261058-yu2qw02l 113 9 characteristic characteristic JJ cord-261058-yu2qw02l 113 10 of of IN cord-261058-yu2qw02l 113 11 a a DT cord-261058-yu2qw02l 113 12 severe severe JJ cord-261058-yu2qw02l 113 13 acute acute JJ cord-261058-yu2qw02l 113 14 childhood childhood NN cord-261058-yu2qw02l 113 15 infection infection NN cord-261058-yu2qw02l 113 16 . . . cord-261058-yu2qw02l 114 1 It -PRON- PRP cord-261058-yu2qw02l 114 2 seems seem VBZ cord-261058-yu2qw02l 114 3 likely likely JJ cord-261058-yu2qw02l 114 4 that that IN cord-261058-yu2qw02l 114 5 the the DT cord-261058-yu2qw02l 114 6 causative causative JJ cord-261058-yu2qw02l 114 7 agents agent NNS cord-261058-yu2qw02l 114 8 are be VBP cord-261058-yu2qw02l 114 9 widely widely RB cord-261058-yu2qw02l 114 10 distributed distribute VBN cord-261058-yu2qw02l 114 11 and and CC cord-261058-yu2qw02l 114 12 are be VBP cord-261058-yu2qw02l 114 13 also also RB cord-261058-yu2qw02l 114 14 highly highly RB cord-261058-yu2qw02l 114 15 immunogenic immunogenic JJ cord-261058-yu2qw02l 114 16 , , , cord-261058-yu2qw02l 114 17 at at IN cord-261058-yu2qw02l 114 18 least least JJS cord-261058-yu2qw02l 114 19 in in IN cord-261058-yu2qw02l 114 20 most most JJS cord-261058-yu2qw02l 114 21 children child NNS cord-261058-yu2qw02l 114 22 , , , cord-261058-yu2qw02l 114 23 as as IN cord-261058-yu2qw02l 114 24 more more JJR cord-261058-yu2qw02l 114 25 than than IN cord-261058-yu2qw02l 114 26 one one CD cord-261058-yu2qw02l 114 27 episode episode NN cord-261058-yu2qw02l 114 28 of of IN cord-261058-yu2qw02l 114 29 KD KD NNP cord-261058-yu2qw02l 114 30 is be VBZ cord-261058-yu2qw02l 114 31 rare rare JJ cord-261058-yu2qw02l 114 32 . . . cord-261058-yu2qw02l 115 1 Recurrent recurrent JJ cord-261058-yu2qw02l 115 2 KD KD NNP cord-261058-yu2qw02l 115 3 is be VBZ cord-261058-yu2qw02l 115 4 reported report VBN cord-261058-yu2qw02l 115 5 in in IN cord-261058-yu2qw02l 115 6 1 1 CD cord-261058-yu2qw02l 115 7 - - SYM cord-261058-yu2qw02l 115 8 3 3 CD cord-261058-yu2qw02l 115 9 % % NN cord-261058-yu2qw02l 115 10 of of IN cord-261058-yu2qw02l 115 11 children child NNS cord-261058-yu2qw02l 115 12 , , , cord-261058-yu2qw02l 115 13 45 45 CD cord-261058-yu2qw02l 115 14 although although IN cord-261058-yu2qw02l 115 15 it -PRON- PRP cord-261058-yu2qw02l 115 16 appears appear VBZ cord-261058-yu2qw02l 115 17 less less RBR cord-261058-yu2qw02l 115 18 common common JJ cord-261058-yu2qw02l 115 19 in in IN cord-261058-yu2qw02l 115 20 Caucasians Caucasians NNPS cord-261058-yu2qw02l 115 21 . . . cord-261058-yu2qw02l 116 1 46 46 CD cord-261058-yu2qw02l 117 1 It -PRON- PRP cord-261058-yu2qw02l 117 2 may may MD cord-261058-yu2qw02l 117 3 reflect reflect VB cord-261058-yu2qw02l 117 4 a a DT cord-261058-yu2qw02l 117 5 specific specific JJ cord-261058-yu2qw02l 117 6 immunological immunological JJ cord-261058-yu2qw02l 117 7 deficiency deficiency NN cord-261058-yu2qw02l 117 8 in in IN cord-261058-yu2qw02l 117 9 these these DT cord-261058-yu2qw02l 117 10 children child NNS cord-261058-yu2qw02l 117 11 or or CC cord-261058-yu2qw02l 117 12 exposure exposure NN cord-261058-yu2qw02l 117 13 to to IN cord-261058-yu2qw02l 117 14 more more JJR cord-261058-yu2qw02l 117 15 than than IN cord-261058-yu2qw02l 117 16 one one CD cord-261058-yu2qw02l 117 17 causative causative JJ cord-261058-yu2qw02l 117 18 agent agent NN cord-261058-yu2qw02l 117 19 . . . cord-261058-yu2qw02l 118 1 3 3 CD cord-261058-yu2qw02l 118 2 Various various JJ cord-261058-yu2qw02l 118 3 environmental environmental JJ cord-261058-yu2qw02l 118 4 causes cause NNS cord-261058-yu2qw02l 118 5 of of IN cord-261058-yu2qw02l 118 6 KD KD NNP cord-261058-yu2qw02l 118 7 have have VBP cord-261058-yu2qw02l 118 8 been be VBN cord-261058-yu2qw02l 118 9 repeatedly repeatedly RB cord-261058-yu2qw02l 118 10 suggested suggest VBN cord-261058-yu2qw02l 118 11 ( ( -LRB- cord-261058-yu2qw02l 118 12 Table Table NNP cord-261058-yu2qw02l 118 13 3 3 CD cord-261058-yu2qw02l 118 14 ) ) -RRB- cord-261058-yu2qw02l 118 15 , , , cord-261058-yu2qw02l 118 16 but but CC cord-261058-yu2qw02l 118 17 none none NN cord-261058-yu2qw02l 118 18 has have VBZ cord-261058-yu2qw02l 118 19 been be VBN cord-261058-yu2qw02l 118 20 consistently consistently RB cord-261058-yu2qw02l 118 21 replicated replicate VBN cord-261058-yu2qw02l 118 22 . . . cord-261058-yu2qw02l 119 1 However however RB cord-261058-yu2qw02l 119 2 , , , cord-261058-yu2qw02l 119 3 the the DT cord-261058-yu2qw02l 119 4 possibility possibility NN cord-261058-yu2qw02l 119 5 of of IN cord-261058-yu2qw02l 119 6 environmental environmental JJ cord-261058-yu2qw02l 119 7 factors factor NNS cord-261058-yu2qw02l 119 8 influencing influence VBG cord-261058-yu2qw02l 119 9 etiology etiology NN cord-261058-yu2qw02l 119 10 , , , cord-261058-yu2qw02l 119 11 possibly possibly RB cord-261058-yu2qw02l 119 12 by by IN cord-261058-yu2qw02l 119 13 modulating modulate VBG cord-261058-yu2qw02l 119 14 infection infection NN cord-261058-yu2qw02l 119 15 risk risk NN cord-261058-yu2qw02l 119 16 , , , cord-261058-yu2qw02l 119 17 remains remain VBZ cord-261058-yu2qw02l 119 18 a a DT cord-261058-yu2qw02l 119 19 possibility possibility NN cord-261058-yu2qw02l 119 20 . . . cord-261058-yu2qw02l 120 1 The the DT cord-261058-yu2qw02l 120 2 search search NN cord-261058-yu2qw02l 120 3 for for IN cord-261058-yu2qw02l 120 4 a a DT cord-261058-yu2qw02l 120 5 single single JJ cord-261058-yu2qw02l 120 6 unifying unifying JJ cord-261058-yu2qw02l 120 7 microbiological microbiological JJ cord-261058-yu2qw02l 120 8 cause cause NN cord-261058-yu2qw02l 120 9 has have VBZ cord-261058-yu2qw02l 120 10 been be VBN cord-261058-yu2qw02l 120 11 unrelenting unrelenting JJ cord-261058-yu2qw02l 120 12 but but CC cord-261058-yu2qw02l 120 13 , , , cord-261058-yu2qw02l 120 14 to to IN cord-261058-yu2qw02l 120 15 date date NN cord-261058-yu2qw02l 120 16 , , , cord-261058-yu2qw02l 120 17 fruitless fruitless JJ cord-261058-yu2qw02l 120 18 . . . cord-261058-yu2qw02l 121 1 Standard standard JJ cord-261058-yu2qw02l 121 2 microbiological microbiological JJ cord-261058-yu2qw02l 121 3 techniques technique NNS cord-261058-yu2qw02l 121 4 , , , cord-261058-yu2qw02l 121 5 molecular molecular JJ cord-261058-yu2qw02l 121 6 methods method NNS cord-261058-yu2qw02l 121 7 and and CC cord-261058-yu2qw02l 121 8 serological serological JJ cord-261058-yu2qw02l 121 9 investigations investigation NNS cord-261058-yu2qw02l 121 10 have have VBP cord-261058-yu2qw02l 121 11 so so RB cord-261058-yu2qw02l 121 12 far far RB cord-261058-yu2qw02l 121 13 failed fail VBN cord-261058-yu2qw02l 121 14 to to TO cord-261058-yu2qw02l 121 15 identify identify VB cord-261058-yu2qw02l 121 16 an an DT cord-261058-yu2qw02l 121 17 etiological etiological JJ cord-261058-yu2qw02l 121 18 agent agent NN cord-261058-yu2qw02l 121 19 . . . cord-261058-yu2qw02l 122 1 Molecular molecular JJ cord-261058-yu2qw02l 122 2 techniques technique NNS cord-261058-yu2qw02l 122 3 fail fail VBP cord-261058-yu2qw02l 122 4 to to TO cord-261058-yu2qw02l 122 5 detect detect VB cord-261058-yu2qw02l 122 6 circulating circulate VBG cord-261058-yu2qw02l 122 7 conserved conserve VBN cord-261058-yu2qw02l 122 8 microbial microbial JJ cord-261058-yu2qw02l 122 9 sequences sequence NNS cord-261058-yu2qw02l 122 10 in in IN cord-261058-yu2qw02l 122 11 KD KD NNP cord-261058-yu2qw02l 122 12 , , , cord-261058-yu2qw02l 122 13 47 47 CD cord-261058-yu2qw02l 122 14 indicating indicate VBG cord-261058-yu2qw02l 122 15 that that IN cord-261058-yu2qw02l 122 16 the the DT cord-261058-yu2qw02l 122 17 antigenic antigenic JJ cord-261058-yu2qw02l 122 18 stimulus stimulus NN cord-261058-yu2qw02l 122 19 may may MD cord-261058-yu2qw02l 122 20 arise arise VB cord-261058-yu2qw02l 122 21 from from IN cord-261058-yu2qw02l 122 22 a a DT cord-261058-yu2qw02l 122 23 distant distant JJ cord-261058-yu2qw02l 122 24 site site NN cord-261058-yu2qw02l 122 25 ( ( -LRB- cord-261058-yu2qw02l 122 26 e.g. e.g. RB cord-261058-yu2qw02l 122 27 colonising colonise VBG cord-261058-yu2qw02l 122 28 pathogens pathogen NNS cord-261058-yu2qw02l 122 29 in in IN cord-261058-yu2qw02l 122 30 the the DT cord-261058-yu2qw02l 122 31 nasopharynx nasopharynx NN cord-261058-yu2qw02l 122 32 ) ) -RRB- cord-261058-yu2qw02l 123 1 and/or and/or CC cord-261058-yu2qw02l 123 2 may may MD cord-261058-yu2qw02l 123 3 represent represent VB cord-261058-yu2qw02l 123 4 host host NN cord-261058-yu2qw02l 123 5 - - HYPH cord-261058-yu2qw02l 123 6 derived derive VBN cord-261058-yu2qw02l 123 7 factor(s factor(s NNP cord-261058-yu2qw02l 123 8 ) ) -RRB- cord-261058-yu2qw02l 123 9 that that WDT cord-261058-yu2qw02l 123 10 induce induce VBP cord-261058-yu2qw02l 123 11 or or CC cord-261058-yu2qw02l 123 12 promote promote VB cord-261058-yu2qw02l 123 13 the the DT cord-261058-yu2qw02l 123 14 pro pro JJ cord-261058-yu2qw02l 123 15 - - JJ cord-261058-yu2qw02l 123 16 inflammatory inflammatory JJ cord-261058-yu2qw02l 123 17 cascade cascade NN cord-261058-yu2qw02l 123 18 . . . cord-261058-yu2qw02l 124 1 The the DT cord-261058-yu2qw02l 124 2 list list NN cord-261058-yu2qw02l 124 3 of of IN cord-261058-yu2qw02l 124 4 discarded discard VBN cord-261058-yu2qw02l 124 5 and/or and/or CC cord-261058-yu2qw02l 124 6 unproven unproven JJ cord-261058-yu2qw02l 124 7 etiological etiological JJ cord-261058-yu2qw02l 124 8 agents agent NNS cord-261058-yu2qw02l 124 9 in in IN cord-261058-yu2qw02l 124 10 KD KD NNP cord-261058-yu2qw02l 124 11 is be VBZ cord-261058-yu2qw02l 124 12 long long JJ cord-261058-yu2qw02l 124 13 ( ( -LRB- cord-261058-yu2qw02l 124 14 Table Table NNP cord-261058-yu2qw02l 124 15 3 3 CD cord-261058-yu2qw02l 124 16 ) ) -RRB- cord-261058-yu2qw02l 124 17 . . . cord-261058-yu2qw02l 125 1 A a DT cord-261058-yu2qw02l 125 2 recent recent JJ cord-261058-yu2qw02l 125 3 report report NN cord-261058-yu2qw02l 125 4 of of IN cord-261058-yu2qw02l 125 5 an an DT cord-261058-yu2qw02l 125 6 association association NN cord-261058-yu2qw02l 125 7 between between IN cord-261058-yu2qw02l 125 8 the the DT cord-261058-yu2qw02l 125 9 presence presence NN cord-261058-yu2qw02l 125 10 of of IN cord-261058-yu2qw02l 125 11 genetic genetic JJ cord-261058-yu2qw02l 125 12 material material NN cord-261058-yu2qw02l 125 13 from from IN cord-261058-yu2qw02l 125 14 a a DT cord-261058-yu2qw02l 125 15 novel novel JJ cord-261058-yu2qw02l 125 16 coronavirus coronavirus NN cord-261058-yu2qw02l 125 17 and and CC cord-261058-yu2qw02l 125 18 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 125 19 disease disease NN cord-261058-yu2qw02l 125 20 in in IN cord-261058-yu2qw02l 125 21 a a DT cord-261058-yu2qw02l 125 22 handful handful NN cord-261058-yu2qw02l 125 23 of of IN cord-261058-yu2qw02l 125 24 cases case NNS cord-261058-yu2qw02l 125 25 48 48 CD cord-261058-yu2qw02l 125 26 remains remain VBZ cord-261058-yu2qw02l 125 27 unproven unproven JJ cord-261058-yu2qw02l 125 28 and and CC cord-261058-yu2qw02l 125 29 may may MD cord-261058-yu2qw02l 125 30 reflect reflect VB cord-261058-yu2qw02l 125 31 an an DT cord-261058-yu2qw02l 125 32 epiphenomenon epiphenomenon NN cord-261058-yu2qw02l 125 33 ; ; : cord-261058-yu2qw02l 125 34 the the DT cord-261058-yu2qw02l 125 35 putative putative JJ cord-261058-yu2qw02l 125 36 etiological etiological JJ cord-261058-yu2qw02l 125 37 agent agent NN cord-261058-yu2qw02l 125 38 is be VBZ cord-261058-yu2qw02l 125 39 a a DT cord-261058-yu2qw02l 125 40 relatively relatively RB cord-261058-yu2qw02l 125 41 common common JJ cord-261058-yu2qw02l 125 42 viral viral JJ cord-261058-yu2qw02l 125 43 pathogen pathogen NN cord-261058-yu2qw02l 125 44 in in IN cord-261058-yu2qw02l 125 45 young young JJ cord-261058-yu2qw02l 125 46 children child NNS cord-261058-yu2qw02l 125 47 and and CC cord-261058-yu2qw02l 125 48 it -PRON- PRP cord-261058-yu2qw02l 125 49 is be VBZ cord-261058-yu2qw02l 125 50 unclear unclear JJ cord-261058-yu2qw02l 125 51 how how WRB cord-261058-yu2qw02l 125 52 long long JJ cord-261058-yu2qw02l 125 53 the the DT cord-261058-yu2qw02l 125 54 DNA dna NN cord-261058-yu2qw02l 125 55 persists persist VBZ cord-261058-yu2qw02l 125 56 . . . cord-261058-yu2qw02l 126 1 The the DT cord-261058-yu2qw02l 126 2 lack lack NN cord-261058-yu2qw02l 126 3 of of IN cord-261058-yu2qw02l 126 4 a a DT cord-261058-yu2qw02l 126 5 unifying unifying JJ cord-261058-yu2qw02l 126 6 etiological etiological JJ cord-261058-yu2qw02l 126 7 agent agent NN cord-261058-yu2qw02l 126 8 despite despite IN cord-261058-yu2qw02l 126 9 a a DT cord-261058-yu2qw02l 126 10 significant significant JJ cord-261058-yu2qw02l 126 11 research research NN cord-261058-yu2qw02l 126 12 effort effort NN cord-261058-yu2qw02l 126 13 suggests suggest VBZ cord-261058-yu2qw02l 126 14 that that IN cord-261058-yu2qw02l 126 15 KD KD NNP cord-261058-yu2qw02l 126 16 can can MD cord-261058-yu2qw02l 126 17 follow follow VB cord-261058-yu2qw02l 126 18 exposure exposure NN cord-261058-yu2qw02l 126 19 to to IN cord-261058-yu2qw02l 126 20 more more JJR cord-261058-yu2qw02l 126 21 than than IN cord-261058-yu2qw02l 126 22 one one CD cord-261058-yu2qw02l 126 23 infectious infectious JJ cord-261058-yu2qw02l 126 24 agent agent NN cord-261058-yu2qw02l 126 25 , , , cord-261058-yu2qw02l 126 26 or or CC cord-261058-yu2qw02l 126 27 that that IN cord-261058-yu2qw02l 126 28 a a DT cord-261058-yu2qw02l 126 29 novel novel JJ cord-261058-yu2qw02l 126 30 infectious infectious JJ cord-261058-yu2qw02l 126 31 agent agent NN cord-261058-yu2qw02l 126 32 is be VBZ cord-261058-yu2qw02l 126 33 involved involve VBN cord-261058-yu2qw02l 126 34 . . . cord-261058-yu2qw02l 127 1 Alternatively alternatively RB cord-261058-yu2qw02l 127 2 the the DT cord-261058-yu2qw02l 127 3 clinical clinical JJ cord-261058-yu2qw02l 127 4 phenotype phenotype NN cord-261058-yu2qw02l 127 5 may may MD cord-261058-yu2qw02l 127 6 reflect reflect VB cord-261058-yu2qw02l 127 7 a a DT cord-261058-yu2qw02l 127 8 stereotyped stereotyped JJ cord-261058-yu2qw02l 127 9 response response NN cord-261058-yu2qw02l 127 10 in in IN cord-261058-yu2qw02l 127 11 a a DT cord-261058-yu2qw02l 127 12 genetically genetically RB cord-261058-yu2qw02l 127 13 - - HYPH cord-261058-yu2qw02l 127 14 susceptible susceptible JJ cord-261058-yu2qw02l 127 15 host host NN cord-261058-yu2qw02l 127 16 to to IN cord-261058-yu2qw02l 127 17 one one CD cord-261058-yu2qw02l 127 18 of of IN cord-261058-yu2qw02l 127 19 a a DT cord-261058-yu2qw02l 127 20 variety variety NN cord-261058-yu2qw02l 127 21 of of IN cord-261058-yu2qw02l 127 22 infectious infectious JJ cord-261058-yu2qw02l 127 23 agents agent NNS cord-261058-yu2qw02l 127 24 . . . cord-261058-yu2qw02l 128 1 Much much JJ cord-261058-yu2qw02l 128 2 of of IN cord-261058-yu2qw02l 128 3 the the DT cord-261058-yu2qw02l 128 4 continuing continue VBG cord-261058-yu2qw02l 128 5 debate debate NN cord-261058-yu2qw02l 128 6 in in IN cord-261058-yu2qw02l 128 7 the the DT cord-261058-yu2qw02l 128 8 literature literature NN cord-261058-yu2qw02l 128 9 concerns concern NNS cord-261058-yu2qw02l 128 10 whether whether IN cord-261058-yu2qw02l 128 11 KD KD NNP cord-261058-yu2qw02l 128 12 is be VBZ cord-261058-yu2qw02l 128 13 caused cause VBN cord-261058-yu2qw02l 128 14 by by IN cord-261058-yu2qw02l 128 15 a a DT cord-261058-yu2qw02l 128 16 superantigen superantigen NN cord-261058-yu2qw02l 128 17 49 49 CD cord-261058-yu2qw02l 128 18 or or CC cord-261058-yu2qw02l 128 19 a a DT cord-261058-yu2qw02l 128 20 conventional conventional JJ cord-261058-yu2qw02l 128 21 antigen antigen NN cord-261058-yu2qw02l 128 22 . . . cord-261058-yu2qw02l 129 1 50 50 CD cord-261058-yu2qw02l 129 2 KD KD NNP cord-261058-yu2qw02l 129 3 shares share VBZ cord-261058-yu2qw02l 129 4 many many JJ cord-261058-yu2qw02l 129 5 clinical clinical JJ cord-261058-yu2qw02l 129 6 features feature NNS cord-261058-yu2qw02l 129 7 with with IN cord-261058-yu2qw02l 129 8 superantigen superantigen NN cord-261058-yu2qw02l 129 9 - - HYPH cord-261058-yu2qw02l 129 10 mediated mediate VBN cord-261058-yu2qw02l 129 11 diseases disease NNS cord-261058-yu2qw02l 129 12 ( ( -LRB- cord-261058-yu2qw02l 129 13 for for IN cord-261058-yu2qw02l 129 14 example example NN cord-261058-yu2qw02l 129 15 , , , cord-261058-yu2qw02l 129 16 rash rash JJ cord-261058-yu2qw02l 129 17 , , , cord-261058-yu2qw02l 129 18 conjunctivitis conjunctivitis NN cord-261058-yu2qw02l 129 19 and and CC cord-261058-yu2qw02l 129 20 skin skin NN cord-261058-yu2qw02l 129 21 peeling peeling NN cord-261058-yu2qw02l 129 22 ) ) -RRB- cord-261058-yu2qw02l 129 23 and and CC cord-261058-yu2qw02l 129 24 KD KD NNP cord-261058-yu2qw02l 129 25 has have VBZ cord-261058-yu2qw02l 129 26 occasionally occasionally RB cord-261058-yu2qw02l 129 27 been be VBN cord-261058-yu2qw02l 129 28 reported report VBN cord-261058-yu2qw02l 129 29 concurrently concurrently RB cord-261058-yu2qw02l 129 30 in in IN cord-261058-yu2qw02l 129 31 children child NNS cord-261058-yu2qw02l 129 32 with with IN cord-261058-yu2qw02l 129 33 toxic toxic JJ cord-261058-yu2qw02l 129 34 - - HYPH cord-261058-yu2qw02l 129 35 shock shock NN cord-261058-yu2qw02l 129 36 syndrome syndrome NN cord-261058-yu2qw02l 129 37 , , , cord-261058-yu2qw02l 129 38 which which WDT cord-261058-yu2qw02l 129 39 is be VBZ cord-261058-yu2qw02l 129 40 caused cause VBN cord-261058-yu2qw02l 129 41 by by IN cord-261058-yu2qw02l 129 42 superantigens superantigens NNP cord-261058-yu2qw02l 129 43 . . . cord-261058-yu2qw02l 130 1 51 51 CD cord-261058-yu2qw02l 131 1 However however RB cord-261058-yu2qw02l 131 2 , , , cord-261058-yu2qw02l 131 3 unequivocal unequivocal JJ cord-261058-yu2qw02l 131 4 epidemiological epidemiological JJ cord-261058-yu2qw02l 131 5 and and CC cord-261058-yu2qw02l 131 6 laboratory laboratory NN cord-261058-yu2qw02l 131 7 support support NN cord-261058-yu2qw02l 131 8 for for IN cord-261058-yu2qw02l 131 9 a a DT cord-261058-yu2qw02l 131 10 role role NN cord-261058-yu2qw02l 131 11 for for IN cord-261058-yu2qw02l 131 12 superantigens superantigen NNS cord-261058-yu2qw02l 131 13 in in IN cord-261058-yu2qw02l 131 14 KD KD NNP cord-261058-yu2qw02l 131 15 is be VBZ cord-261058-yu2qw02l 131 16 lacking lack VBG cord-261058-yu2qw02l 131 17 . . . cord-261058-yu2qw02l 132 1 In in IN cord-261058-yu2qw02l 132 2 one one CD cord-261058-yu2qw02l 132 3 small small JJ cord-261058-yu2qw02l 132 4 study study NN cord-261058-yu2qw02l 132 5 , , , cord-261058-yu2qw02l 132 6 maternal maternal JJ cord-261058-yu2qw02l 132 7 antibodies antibody NNS cord-261058-yu2qw02l 132 8 against against IN cord-261058-yu2qw02l 132 9 toxic toxic JJ cord-261058-yu2qw02l 132 10 shock shock NN cord-261058-yu2qw02l 132 11 syndrome syndrome NN cord-261058-yu2qw02l 132 12 toxin-1 toxin-1 NNP cord-261058-yu2qw02l 132 13 appeared appear VBD cord-261058-yu2qw02l 132 14 protective protective JJ cord-261058-yu2qw02l 132 15 against against IN cord-261058-yu2qw02l 132 16 early early JJ cord-261058-yu2qw02l 132 17 - - HYPH cord-261058-yu2qw02l 132 18 onset onset NN cord-261058-yu2qw02l 132 19 KD KD NNP cord-261058-yu2qw02l 132 20 . . . cord-261058-yu2qw02l 133 1 52 52 CD cord-261058-yu2qw02l 134 1 However however RB cord-261058-yu2qw02l 134 2 , , , cord-261058-yu2qw02l 134 3 the the DT cord-261058-yu2qw02l 134 4 carriage carriage NN cord-261058-yu2qw02l 134 5 rates rate NNS cord-261058-yu2qw02l 134 6 of of IN cord-261058-yu2qw02l 134 7 superantigen superantigen NN cord-261058-yu2qw02l 134 8 - - HYPH cord-261058-yu2qw02l 134 9 producing produce VBG cord-261058-yu2qw02l 134 10 bacteria bacteria NNS cord-261058-yu2qw02l 134 11 by by IN cord-261058-yu2qw02l 134 12 children child NNS cord-261058-yu2qw02l 134 13 with with IN cord-261058-yu2qw02l 134 14 KD KD NNP cord-261058-yu2qw02l 134 15 are be VBP cord-261058-yu2qw02l 134 16 not not RB cord-261058-yu2qw02l 134 17 consistently consistently RB cord-261058-yu2qw02l 134 18 increased increase VBN cord-261058-yu2qw02l 134 19 , , , cord-261058-yu2qw02l 134 20 53 53 CD cord-261058-yu2qw02l 134 21 , , , cord-261058-yu2qw02l 134 22 54 54 CD cord-261058-yu2qw02l 134 23 although although IN cord-261058-yu2qw02l 134 24 these these DT cord-261058-yu2qw02l 134 25 data datum NNS cord-261058-yu2qw02l 134 26 may may MD cord-261058-yu2qw02l 134 27 reflect reflect VB cord-261058-yu2qw02l 134 28 the the DT cord-261058-yu2qw02l 134 29 involvement involvement NN cord-261058-yu2qw02l 134 30 of of IN cord-261058-yu2qw02l 134 31 as as RB cord-261058-yu2qw02l 134 32 yet yet RB cord-261058-yu2qw02l 134 33 unidentified unidentified JJ cord-261058-yu2qw02l 134 34 188 188 CD cord-261058-yu2qw02l 134 35 D. D. NNP cord-261058-yu2qw02l 134 36 Burgner Burgner NNP cord-261058-yu2qw02l 134 37 , , , cord-261058-yu2qw02l 134 38 A. A. NNP cord-261058-yu2qw02l 134 39 Harnden Harnden NNP cord-261058-yu2qw02l 134 40 superantigens superantigen NNS cord-261058-yu2qw02l 134 41 , , , cord-261058-yu2qw02l 134 42 with with IN cord-261058-yu2qw02l 134 43 more more JJR cord-261058-yu2qw02l 134 44 than than IN cord-261058-yu2qw02l 134 45 one one CD cord-261058-yu2qw02l 134 46 superantigen superantigen NN cord-261058-yu2qw02l 134 47 capable capable JJ cord-261058-yu2qw02l 134 48 of of IN cord-261058-yu2qw02l 134 49 causing cause VBG cord-261058-yu2qw02l 134 50 KD KD NNP cord-261058-yu2qw02l 134 51 . . . cord-261058-yu2qw02l 135 1 Superantigens Superantigens NNP cord-261058-yu2qw02l 135 2 bind bind NN cord-261058-yu2qw02l 135 3 to to IN cord-261058-yu2qw02l 135 4 the the DT cord-261058-yu2qw02l 135 5 Vb Vb NNP cord-261058-yu2qw02l 135 6 region region NN cord-261058-yu2qw02l 135 7 of of IN cord-261058-yu2qw02l 135 8 the the DT cord-261058-yu2qw02l 135 9 T t NN cord-261058-yu2qw02l 135 10 - - HYPH cord-261058-yu2qw02l 135 11 cell cell NN cord-261058-yu2qw02l 135 12 receptor receptor NN cord-261058-yu2qw02l 135 13 and and CC cord-261058-yu2qw02l 135 14 clonal clonal JJ cord-261058-yu2qw02l 135 15 expansion expansion NN cord-261058-yu2qw02l 135 16 of of IN cord-261058-yu2qw02l 135 17 Vb2-expressing Vb2-expressing NNP cord-261058-yu2qw02l 135 18 T T NNP cord-261058-yu2qw02l 135 19 - - HYPH cord-261058-yu2qw02l 135 20 cells cell NNS cord-261058-yu2qw02l 135 21 has have VBZ cord-261058-yu2qw02l 135 22 been be VBN cord-261058-yu2qw02l 135 23 reported report VBN cord-261058-yu2qw02l 135 24 in in IN cord-261058-yu2qw02l 135 25 some some DT cord-261058-yu2qw02l 135 26 studies study NNS cord-261058-yu2qw02l 135 27 of of IN cord-261058-yu2qw02l 135 28 KD KD NNP cord-261058-yu2qw02l 135 29 , , , cord-261058-yu2qw02l 135 30 55 55 CD cord-261058-yu2qw02l 135 31 but but CC cord-261058-yu2qw02l 135 32 again again RB cord-261058-yu2qw02l 135 33 the the DT cord-261058-yu2qw02l 135 34 finding finding NN cord-261058-yu2qw02l 135 35 is be VBZ cord-261058-yu2qw02l 135 36 inconsistent inconsistent JJ cord-261058-yu2qw02l 135 37 . . . cord-261058-yu2qw02l 136 1 56 56 CD cord-261058-yu2qw02l 136 2 Other other JJ cord-261058-yu2qw02l 136 3 studies study NNS cord-261058-yu2qw02l 136 4 have have VBP cord-261058-yu2qw02l 136 5 reported report VBN cord-261058-yu2qw02l 136 6 oligoclonal oligoclonal JJ cord-261058-yu2qw02l 136 7 IgAproducing IgAproducing NNP cord-261058-yu2qw02l 136 8 plasma plasma NN cord-261058-yu2qw02l 136 9 cells cell NNS cord-261058-yu2qw02l 136 10 infiltrating infiltrate VBG cord-261058-yu2qw02l 136 11 bronchial bronchial JJ cord-261058-yu2qw02l 136 12 and and CC cord-261058-yu2qw02l 136 13 intestinal intestinal JJ cord-261058-yu2qw02l 136 14 tissues tissue NNS cord-261058-yu2qw02l 136 15 in in IN cord-261058-yu2qw02l 136 16 fatal fatal JJ cord-261058-yu2qw02l 136 17 KD KD NNP cord-261058-yu2qw02l 136 18 , , , cord-261058-yu2qw02l 136 19 57 57 CD cord-261058-yu2qw02l 136 20 which which WDT cord-261058-yu2qw02l 136 21 suggests suggest VBZ cord-261058-yu2qw02l 136 22 the the DT cord-261058-yu2qw02l 136 23 involvement involvement NN cord-261058-yu2qw02l 136 24 of of IN cord-261058-yu2qw02l 136 25 a a DT cord-261058-yu2qw02l 136 26 conventional conventional JJ cord-261058-yu2qw02l 136 27 antigen antigen NN cord-261058-yu2qw02l 136 28 . . . cord-261058-yu2qw02l 137 1 Much much JJ cord-261058-yu2qw02l 137 2 of of IN cord-261058-yu2qw02l 137 3 the the DT cord-261058-yu2qw02l 137 4 controversy controversy NN cord-261058-yu2qw02l 137 5 and and CC cord-261058-yu2qw02l 137 6 inconsistency inconsistency NN cord-261058-yu2qw02l 137 7 surrounding surround VBG cord-261058-yu2qw02l 137 8 the the DT cord-261058-yu2qw02l 137 9 nature nature NN cord-261058-yu2qw02l 137 10 of of IN cord-261058-yu2qw02l 137 11 the the DT cord-261058-yu2qw02l 137 12 infectious infectious JJ cord-261058-yu2qw02l 137 13 trigger trigger NN cord-261058-yu2qw02l 137 14 in in IN cord-261058-yu2qw02l 137 15 KD KD NNP cord-261058-yu2qw02l 137 16 might may MD cord-261058-yu2qw02l 137 17 reflect reflect VB cord-261058-yu2qw02l 137 18 multiple multiple JJ cord-261058-yu2qw02l 137 19 etiological etiological JJ cord-261058-yu2qw02l 137 20 agents agent NNS cord-261058-yu2qw02l 137 21 resulting result VBG cord-261058-yu2qw02l 137 22 in in IN cord-261058-yu2qw02l 137 23 the the DT cord-261058-yu2qw02l 137 24 same same JJ cord-261058-yu2qw02l 137 25 clinical clinical JJ cord-261058-yu2qw02l 137 26 phenotype phenotype NN cord-261058-yu2qw02l 137 27 . . . cord-261058-yu2qw02l 138 1 It -PRON- PRP cord-261058-yu2qw02l 138 2 is be VBZ cord-261058-yu2qw02l 138 3 possible possible JJ cord-261058-yu2qw02l 138 4 , , , cord-261058-yu2qw02l 138 5 for for IN cord-261058-yu2qw02l 138 6 example example NN cord-261058-yu2qw02l 138 7 , , , cord-261058-yu2qw02l 138 8 that that IN cord-261058-yu2qw02l 138 9 a a DT cord-261058-yu2qw02l 138 10 viral viral JJ cord-261058-yu2qw02l 138 11 upper upper JJ cord-261058-yu2qw02l 138 12 respiratory respiratory JJ cord-261058-yu2qw02l 138 13 tract tract NN cord-261058-yu2qw02l 138 14 infection infection NN cord-261058-yu2qw02l 138 15 may may MD cord-261058-yu2qw02l 138 16 alter alter VB cord-261058-yu2qw02l 138 17 local local JJ cord-261058-yu2qw02l 138 18 immunity immunity NN cord-261058-yu2qw02l 138 19 and and CC cord-261058-yu2qw02l 138 20 allow allow VB cord-261058-yu2qw02l 138 21 elaboration elaboration NN cord-261058-yu2qw02l 138 22 of of IN cord-261058-yu2qw02l 138 23 superantigens superantigen NNS cord-261058-yu2qw02l 138 24 by by IN cord-261058-yu2qw02l 138 25 colonising colonise VBG cord-261058-yu2qw02l 138 26 bacteria bacteria NNS cord-261058-yu2qw02l 138 27 in in IN cord-261058-yu2qw02l 138 28 the the DT cord-261058-yu2qw02l 138 29 nasopharynx nasopharynx NN cord-261058-yu2qw02l 138 30 . . . cord-261058-yu2qw02l 139 1 Certainly certainly RB cord-261058-yu2qw02l 139 2 the the DT cord-261058-yu2qw02l 139 3 epidemiology epidemiology NN cord-261058-yu2qw02l 139 4 of of IN cord-261058-yu2qw02l 139 5 KD KD NNP cord-261058-yu2qw02l 139 6 , , , cord-261058-yu2qw02l 139 7 with with IN cord-261058-yu2qw02l 139 8 rapid rapid JJ cord-261058-yu2qw02l 139 9 changes change NNS cord-261058-yu2qw02l 139 10 in in IN cord-261058-yu2qw02l 139 11 incidence incidence NN cord-261058-yu2qw02l 139 12 , , , cord-261058-yu2qw02l 139 13 seasonal seasonal JJ cord-261058-yu2qw02l 139 14 variation variation NN cord-261058-yu2qw02l 139 15 and and CC cord-261058-yu2qw02l 139 16 the the DT cord-261058-yu2qw02l 139 17 relationship relationship NN cord-261058-yu2qw02l 139 18 between between IN cord-261058-yu2qw02l 139 19 incidence incidence NN cord-261058-yu2qw02l 139 20 and and CC cord-261058-yu2qw02l 139 21 weather weather NN cord-261058-yu2qw02l 139 22 conditions condition NNS cord-261058-yu2qw02l 139 23 is be VBZ cord-261058-yu2qw02l 139 24 more more RBR cord-261058-yu2qw02l 139 25 redolent redolent JJ cord-261058-yu2qw02l 139 26 of of IN cord-261058-yu2qw02l 139 27 acute acute JJ cord-261058-yu2qw02l 139 28 viral viral JJ cord-261058-yu2qw02l 139 29 infections infection NNS cord-261058-yu2qw02l 139 30 58,59 58,59 CD cord-261058-yu2qw02l 139 31 than than IN cord-261058-yu2qw02l 139 32 bacterial bacterial JJ cord-261058-yu2qw02l 139 33 colonisation colonisation NN cord-261058-yu2qw02l 139 34 , , , cord-261058-yu2qw02l 139 35 which which WDT cord-261058-yu2qw02l 139 36 alters alter VBZ cord-261058-yu2qw02l 139 37 more more RBR cord-261058-yu2qw02l 139 38 slowly slowly RB cord-261058-yu2qw02l 139 39 . . . cord-261058-yu2qw02l 140 1 60 60 CD cord-261058-yu2qw02l 141 1 In in IN cord-261058-yu2qw02l 141 2 meningococcal meningococcal JJ cord-261058-yu2qw02l 141 3 disease disease NN cord-261058-yu2qw02l 141 4 , , , cord-261058-yu2qw02l 141 5 influenza influenza NN cord-261058-yu2qw02l 141 6 infection infection NN cord-261058-yu2qw02l 141 7 acts act VBZ cord-261058-yu2qw02l 141 8 in in IN cord-261058-yu2qw02l 141 9 an an DT cord-261058-yu2qw02l 141 10 analogous analogous JJ cord-261058-yu2qw02l 141 11 way way NN cord-261058-yu2qw02l 141 12 , , , cord-261058-yu2qw02l 141 13 and and CC cord-261058-yu2qw02l 141 14 meningococcal meningococcal JJ cord-261058-yu2qw02l 141 15 epidemics epidemic NNS cord-261058-yu2qw02l 141 16 often often RB cord-261058-yu2qw02l 141 17 follow follow VBP cord-261058-yu2qw02l 141 18 influenza influenza NN cord-261058-yu2qw02l 141 19 outbreaks outbreak NNS cord-261058-yu2qw02l 141 20 . . . cord-261058-yu2qw02l 142 1 61 61 CD cord-261058-yu2qw02l 142 2 , , , cord-261058-yu2qw02l 142 3 62 62 CD cord-261058-yu2qw02l 143 1 This this DT cord-261058-yu2qw02l 143 2 hypothesis hypothesis NN cord-261058-yu2qw02l 143 3 could could MD cord-261058-yu2qw02l 143 4 be be VB cord-261058-yu2qw02l 143 5 addressed address VBN cord-261058-yu2qw02l 143 6 through through IN cord-261058-yu2qw02l 143 7 large large JJ cord-261058-yu2qw02l 143 8 detailed detailed JJ cord-261058-yu2qw02l 143 9 prospective prospective JJ cord-261058-yu2qw02l 143 10 epidemiological epidemiological JJ cord-261058-yu2qw02l 143 11 studies study NNS cord-261058-yu2qw02l 143 12 . . . cord-261058-yu2qw02l 144 1 Another another DT cord-261058-yu2qw02l 144 2 possibility possibility NN cord-261058-yu2qw02l 144 3 is be VBZ cord-261058-yu2qw02l 144 4 that that IN cord-261058-yu2qw02l 144 5 either either CC cord-261058-yu2qw02l 144 6 pathogen pathogen NN cord-261058-yu2qw02l 144 7 or or CC cord-261058-yu2qw02l 144 8 host host NN cord-261058-yu2qw02l 144 9 factors factor NNS cord-261058-yu2qw02l 144 10 modulate modulate VBP cord-261058-yu2qw02l 144 11 the the DT cord-261058-yu2qw02l 144 12 behaviour behaviour NN cord-261058-yu2qw02l 144 13 of of IN cord-261058-yu2qw02l 144 14 an an DT cord-261058-yu2qw02l 144 15 antigen antigen NN cord-261058-yu2qw02l 144 16 , , , cord-261058-yu2qw02l 144 17 so so IN cord-261058-yu2qw02l 144 18 that that IN cord-261058-yu2qw02l 144 19 it -PRON- PRP cord-261058-yu2qw02l 144 20 behaves behave VBZ cord-261058-yu2qw02l 144 21 both both DT cord-261058-yu2qw02l 144 22 as as IN cord-261058-yu2qw02l 144 23 a a DT cord-261058-yu2qw02l 144 24 conventional conventional JJ cord-261058-yu2qw02l 144 25 antigen antigen NN cord-261058-yu2qw02l 144 26 and and CC cord-261058-yu2qw02l 144 27 as as IN cord-261058-yu2qw02l 144 28 a a DT cord-261058-yu2qw02l 144 29 superantigen superantigen NN cord-261058-yu2qw02l 144 30 . . . cord-261058-yu2qw02l 145 1 Heat heat NN cord-261058-yu2qw02l 145 2 shock shock NN cord-261058-yu2qw02l 145 3 proteins protein NNS cord-261058-yu2qw02l 145 4 are be VBP cord-261058-yu2qw02l 145 5 increased increase VBN cord-261058-yu2qw02l 145 6 in in IN cord-261058-yu2qw02l 145 7 acute acute JJ cord-261058-yu2qw02l 145 8 inflammatory inflammatory JJ cord-261058-yu2qw02l 145 9 conditions condition NNS cord-261058-yu2qw02l 145 10 , , , cord-261058-yu2qw02l 145 11 including include VBG cord-261058-yu2qw02l 145 12 KD KD NNP cord-261058-yu2qw02l 145 13 63 63 CD cord-261058-yu2qw02l 145 14 and and CC cord-261058-yu2qw02l 145 15 cross cross NN cord-261058-yu2qw02l 145 16 - - NN cord-261058-yu2qw02l 145 17 reactivity reactivity NN cord-261058-yu2qw02l 145 18 with with IN cord-261058-yu2qw02l 145 19 certain certain JJ cord-261058-yu2qw02l 145 20 heat heat NN cord-261058-yu2qw02l 145 21 shock shock NN cord-261058-yu2qw02l 145 22 proteins protein NNS cord-261058-yu2qw02l 145 23 is be VBZ cord-261058-yu2qw02l 145 24 thought think VBN cord-261058-yu2qw02l 145 25 to to TO cord-261058-yu2qw02l 145 26 be be VB cord-261058-yu2qw02l 145 27 responsible responsible JJ cord-261058-yu2qw02l 145 28 for for IN cord-261058-yu2qw02l 145 29 the the DT cord-261058-yu2qw02l 145 30 inflammation inflammation NN cord-261058-yu2qw02l 145 31 of of IN cord-261058-yu2qw02l 145 32 the the DT cord-261058-yu2qw02l 145 33 BCG BCG NNP cord-261058-yu2qw02l 145 34 scar scar NN cord-261058-yu2qw02l 145 35 in in IN cord-261058-yu2qw02l 145 36 KD KD NNP cord-261058-yu2qw02l 145 37 . . . cord-261058-yu2qw02l 146 1 64 64 CD cord-261058-yu2qw02l 146 2 Heat heat NN cord-261058-yu2qw02l 146 3 shock shock NN cord-261058-yu2qw02l 146 4 proteins protein NNS cord-261058-yu2qw02l 146 5 have have VBP cord-261058-yu2qw02l 146 6 been be VBN cord-261058-yu2qw02l 146 7 reported report VBN cord-261058-yu2qw02l 146 8 to to TO cord-261058-yu2qw02l 146 9 alter alter VB cord-261058-yu2qw02l 146 10 the the DT cord-261058-yu2qw02l 146 11 behaviour behaviour NN cord-261058-yu2qw02l 146 12 of of IN cord-261058-yu2qw02l 146 13 superantigens superantigens NNP cord-261058-yu2qw02l 146 14 , , , cord-261058-yu2qw02l 146 15 so so IN cord-261058-yu2qw02l 146 16 that that IN cord-261058-yu2qw02l 146 17 the the DT cord-261058-yu2qw02l 146 18 immune immune JJ cord-261058-yu2qw02l 146 19 system system NN cord-261058-yu2qw02l 146 20 recognises recognise VBZ cord-261058-yu2qw02l 146 21 them -PRON- PRP cord-261058-yu2qw02l 146 22 as as IN cord-261058-yu2qw02l 146 23 conventional conventional JJ cord-261058-yu2qw02l 146 24 antigens antigen NNS cord-261058-yu2qw02l 146 25 65 65 CD cord-261058-yu2qw02l 146 26 and and CC cord-261058-yu2qw02l 146 27 also also RB cord-261058-yu2qw02l 146 28 can can MD cord-261058-yu2qw02l 146 29 greatly greatly RB cord-261058-yu2qw02l 146 30 up up RB cord-261058-yu2qw02l 146 31 - - HYPH cord-261058-yu2qw02l 146 32 regulate regulate VB cord-261058-yu2qw02l 146 33 pro pro JJ cord-261058-yu2qw02l 146 34 - - JJ cord-261058-yu2qw02l 146 35 inflammatory inflammatory JJ cord-261058-yu2qw02l 146 36 responses response NNS cord-261058-yu2qw02l 146 37 to to IN cord-261058-yu2qw02l 146 38 conventional conventional JJ cord-261058-yu2qw02l 146 39 antigens antigen NNS cord-261058-yu2qw02l 146 40 . . . cord-261058-yu2qw02l 147 1 66 66 CD cord-261058-yu2qw02l 148 1 The the DT cord-261058-yu2qw02l 148 2 possibility possibility NN cord-261058-yu2qw02l 148 3 of of IN cord-261058-yu2qw02l 148 4 endogenous endogenous JJ cord-261058-yu2qw02l 148 5 stimuli stimulus NNS cord-261058-yu2qw02l 148 6 that that WDT cord-261058-yu2qw02l 148 7 profoundly profoundly RB cord-261058-yu2qw02l 148 8 suppress suppress VBP cord-261058-yu2qw02l 148 9 or or CC cord-261058-yu2qw02l 148 10 enhance enhance VB cord-261058-yu2qw02l 148 11 antigenic antigenic JJ cord-261058-yu2qw02l 148 12 effects effect NNS cord-261058-yu2qw02l 148 13 has have VBZ cord-261058-yu2qw02l 148 14 not not RB cord-261058-yu2qw02l 148 15 previously previously RB cord-261058-yu2qw02l 148 16 been be VBN cord-261058-yu2qw02l 148 17 considered consider VBN cord-261058-yu2qw02l 148 18 in in IN cord-261058-yu2qw02l 148 19 KD KD NNP cord-261058-yu2qw02l 148 20 , , , cord-261058-yu2qw02l 148 21 but but CC cord-261058-yu2qw02l 148 22 might may MD cord-261058-yu2qw02l 148 23 account account VB cord-261058-yu2qw02l 148 24 for for IN cord-261058-yu2qw02l 148 25 much much JJ cord-261058-yu2qw02l 148 26 of of IN cord-261058-yu2qw02l 148 27 the the DT cord-261058-yu2qw02l 148 28 controversy controversy NN cord-261058-yu2qw02l 148 29 surrounding surround VBG cord-261058-yu2qw02l 148 30 the the DT cord-261058-yu2qw02l 148 31 roles role NNS cord-261058-yu2qw02l 148 32 of of IN cord-261058-yu2qw02l 148 33 conventional conventional JJ cord-261058-yu2qw02l 148 34 or or CC cord-261058-yu2qw02l 148 35 superantigens superantigen NNS cord-261058-yu2qw02l 148 36 . . . cord-261058-yu2qw02l 149 1 Whatever whatever WDT cord-261058-yu2qw02l 149 2 the the DT cord-261058-yu2qw02l 149 3 etiological etiological JJ cord-261058-yu2qw02l 149 4 trigger(s trigger(s NN cord-261058-yu2qw02l 149 5 ) ) -RRB- cord-261058-yu2qw02l 149 6 for for IN cord-261058-yu2qw02l 149 7 KD KD NNP cord-261058-yu2qw02l 149 8 , , , cord-261058-yu2qw02l 149 9 there there EX cord-261058-yu2qw02l 149 10 is be VBZ cord-261058-yu2qw02l 149 11 clear clear JJ cord-261058-yu2qw02l 149 12 evidence evidence NN cord-261058-yu2qw02l 149 13 that that IN cord-261058-yu2qw02l 149 14 host host VBP cord-261058-yu2qw02l 149 15 genetic genetic JJ cord-261058-yu2qw02l 149 16 determinants determinant NNS cord-261058-yu2qw02l 149 17 play play VBP cord-261058-yu2qw02l 149 18 a a DT cord-261058-yu2qw02l 149 19 major major JJ cord-261058-yu2qw02l 149 20 role role NN cord-261058-yu2qw02l 149 21 in in IN cord-261058-yu2qw02l 149 22 both both DT cord-261058-yu2qw02l 149 23 susceptibility susceptibility NN cord-261058-yu2qw02l 149 24 and and CC cord-261058-yu2qw02l 149 25 probably probably RB cord-261058-yu2qw02l 149 26 outcome outcome VBP cord-261058-yu2qw02l 149 27 in in IN cord-261058-yu2qw02l 149 28 KD KD NNP cord-261058-yu2qw02l 149 29 . . . cord-261058-yu2qw02l 150 1 Genetic genetic JJ cord-261058-yu2qw02l 150 2 studies study NNS cord-261058-yu2qw02l 150 3 of of IN cord-261058-yu2qw02l 150 4 KD KD NNP cord-261058-yu2qw02l 150 5 are be VBP cord-261058-yu2qw02l 150 6 therefore therefore RB cord-261058-yu2qw02l 150 7 likely likely JJ cord-261058-yu2qw02l 150 8 to to TO cord-261058-yu2qw02l 150 9 be be VB cord-261058-yu2qw02l 150 10 highly highly RB cord-261058-yu2qw02l 150 11 informative informative JJ cord-261058-yu2qw02l 150 12 about about IN cord-261058-yu2qw02l 150 13 etiology etiology NN cord-261058-yu2qw02l 150 14 and and CC cord-261058-yu2qw02l 150 15 pathogenesis pathogenesis NN cord-261058-yu2qw02l 150 16 . . . cord-261058-yu2qw02l 151 1 Although although IN cord-261058-yu2qw02l 151 2 KD KD NNP cord-261058-yu2qw02l 151 3 is be VBZ cord-261058-yu2qw02l 151 4 reported report VBN cord-261058-yu2qw02l 151 5 in in IN cord-261058-yu2qw02l 151 6 all all DT cord-261058-yu2qw02l 151 7 ethnic ethnic JJ cord-261058-yu2qw02l 151 8 groups group NNS cord-261058-yu2qw02l 151 9 , , , cord-261058-yu2qw02l 151 10 the the DT cord-261058-yu2qw02l 151 11 variation variation NN cord-261058-yu2qw02l 151 12 in in IN cord-261058-yu2qw02l 151 13 incidence incidence NN cord-261058-yu2qw02l 151 14 of of IN cord-261058-yu2qw02l 151 15 KD KD NNP cord-261058-yu2qw02l 151 16 between between IN cord-261058-yu2qw02l 151 17 ( ( -LRB- cord-261058-yu2qw02l 151 18 and and CC cord-261058-yu2qw02l 151 19 to to IN cord-261058-yu2qw02l 151 20 a a DT cord-261058-yu2qw02l 151 21 lesser less JJR cord-261058-yu2qw02l 151 22 extent extent NN cord-261058-yu2qw02l 151 23 within within IN cord-261058-yu2qw02l 151 24 ) ) -RRB- cord-261058-yu2qw02l 151 25 countries country NNS cord-261058-yu2qw02l 151 26 is be VBZ cord-261058-yu2qw02l 151 27 striking striking JJ cord-261058-yu2qw02l 151 28 . . . cord-261058-yu2qw02l 152 1 The the DT cord-261058-yu2qw02l 152 2 annual annual JJ cord-261058-yu2qw02l 152 3 incidence incidence NN cord-261058-yu2qw02l 152 4 varies vary VBZ cord-261058-yu2qw02l 152 5 from from IN cord-261058-yu2qw02l 152 6 approximately approximately RB cord-261058-yu2qw02l 152 7 three three CD cord-261058-yu2qw02l 152 8 ( ( -LRB- cord-261058-yu2qw02l 152 9 per per IN cord-261058-yu2qw02l 152 10 100,000 100,000 CD cord-261058-yu2qw02l 152 11 children child NNS cord-261058-yu2qw02l 152 12 < < XX cord-261058-yu2qw02l 152 13 5 5 CD cord-261058-yu2qw02l 152 14 years year NNS cord-261058-yu2qw02l 152 15 of of IN cord-261058-yu2qw02l 152 16 age age NN cord-261058-yu2qw02l 152 17 ) ) -RRB- cord-261058-yu2qw02l 152 18 in in IN cord-261058-yu2qw02l 152 19 South South NNP cord-261058-yu2qw02l 152 20 America America NNP cord-261058-yu2qw02l 152 21 , , , cord-261058-yu2qw02l 152 22 to to IN cord-261058-yu2qw02l 152 23 four four CD cord-261058-yu2qw02l 152 24 in in IN cord-261058-yu2qw02l 152 25 Australia Australia NNP cord-261058-yu2qw02l 152 26 , , , cord-261058-yu2qw02l 152 27 24 24 CD cord-261058-yu2qw02l 152 28 eight eight CD cord-261058-yu2qw02l 152 29 in in IN cord-261058-yu2qw02l 152 30 the the DT cord-261058-yu2qw02l 152 31 UK UK NNP cord-261058-yu2qw02l 152 32 , , , cord-261058-yu2qw02l 152 33 33 33 CD cord-261058-yu2qw02l 152 34 4 4 CD cord-261058-yu2qw02l 152 35 - - SYM cord-261058-yu2qw02l 152 36 15 15 CD cord-261058-yu2qw02l 152 37 in in IN cord-261058-yu2qw02l 152 38 the the DT cord-261058-yu2qw02l 152 39 US US NNP cord-261058-yu2qw02l 152 40 , , , cord-261058-yu2qw02l 152 41 1 1 CD cord-261058-yu2qw02l 152 42 20 20 CD cord-261058-yu2qw02l 152 43 - - SYM cord-261058-yu2qw02l 152 44 30 30 CD cord-261058-yu2qw02l 152 45 in in IN cord-261058-yu2qw02l 152 46 China China NNP cord-261058-yu2qw02l 152 47 36 36 CD cord-261058-yu2qw02l 152 48 and and CC cord-261058-yu2qw02l 152 49 Hong Hong NNP cord-261058-yu2qw02l 152 50 Kong Kong NNP cord-261058-yu2qw02l 152 51 67 67 CD cord-261058-yu2qw02l 152 52 50 50 CD cord-261058-yu2qw02l 152 53 in in IN cord-261058-yu2qw02l 152 54 Taiwan Taiwan NNP cord-261058-yu2qw02l 152 55 , , , cord-261058-yu2qw02l 152 56 68 68 CD cord-261058-yu2qw02l 152 57 90 90 CD cord-261058-yu2qw02l 152 58 in in IN cord-261058-yu2qw02l 152 59 Korea Korea NNP cord-261058-yu2qw02l 152 60 37 37 CD cord-261058-yu2qw02l 152 61 and and CC cord-261058-yu2qw02l 152 62 > > NFP cord-261058-yu2qw02l 152 63 130 130 CD cord-261058-yu2qw02l 152 64 in in IN cord-261058-yu2qw02l 152 65 Japan Japan NNP cord-261058-yu2qw02l 152 66 69 69 CD cord-261058-yu2qw02l 153 1 The the DT cord-261058-yu2qw02l 153 2 reported report VBN cord-261058-yu2qw02l 153 3 incidence incidence NN cord-261058-yu2qw02l 153 4 is be VBZ cord-261058-yu2qw02l 153 5 probably probably RB cord-261058-yu2qw02l 153 6 underestimated underestimate VBN cord-261058-yu2qw02l 153 7 in in IN cord-261058-yu2qw02l 153 8 many many JJ cord-261058-yu2qw02l 153 9 countries country NNS cord-261058-yu2qw02l 153 10 as as IN cord-261058-yu2qw02l 153 11 atypical atypical JJ cord-261058-yu2qw02l 153 12 cases case NNS cord-261058-yu2qw02l 153 13 are be VBP cord-261058-yu2qw02l 153 14 not not RB cord-261058-yu2qw02l 153 15 included include VBN cord-261058-yu2qw02l 153 16 . . . cord-261058-yu2qw02l 154 1 Australian australian JJ cord-261058-yu2qw02l 154 2 data data NN cord-261058-yu2qw02l 154 3 ( ( -LRB- cord-261058-yu2qw02l 154 4 Burgner Burgner NNP cord-261058-yu2qw02l 154 5 et et NNP cord-261058-yu2qw02l 154 6 al al NNP cord-261058-yu2qw02l 154 7 . . NNP cord-261058-yu2qw02l 154 8 , , , cord-261058-yu2qw02l 154 9 unpublished unpublished JJ cord-261058-yu2qw02l 154 10 ) ) -RRB- cord-261058-yu2qw02l 154 11 suggest suggest VB cord-261058-yu2qw02l 154 12 an an DT cord-261058-yu2qw02l 154 13 incidence incidence NN cord-261058-yu2qw02l 154 14 50 50 CD cord-261058-yu2qw02l 154 15 % % NN cord-261058-yu2qw02l 154 16 higher high JJR cord-261058-yu2qw02l 154 17 than than IN cord-261058-yu2qw02l 154 18 that that DT cord-261058-yu2qw02l 154 19 recorded record VBN cord-261058-yu2qw02l 154 20 through through IN cord-261058-yu2qw02l 154 21 active active JJ cord-261058-yu2qw02l 154 22 surveillance surveillance NN cord-261058-yu2qw02l 154 23 . . . cord-261058-yu2qw02l 155 1 24 24 CD cord-261058-yu2qw02l 156 1 In in IN cord-261058-yu2qw02l 156 2 a a DT cord-261058-yu2qw02l 156 3 number number NN cord-261058-yu2qw02l 156 4 of of IN cord-261058-yu2qw02l 156 5 countries country NNS cord-261058-yu2qw02l 156 6 the the DT cord-261058-yu2qw02l 156 7 incidence incidence NN cord-261058-yu2qw02l 156 8 of of IN cord-261058-yu2qw02l 156 9 KD KD NNP cord-261058-yu2qw02l 156 10 appears appear VBZ cord-261058-yu2qw02l 156 11 to to TO cord-261058-yu2qw02l 156 12 be be VB cord-261058-yu2qw02l 156 13 increasing increase VBG cord-261058-yu2qw02l 156 14 . . . cord-261058-yu2qw02l 157 1 33 33 CD cord-261058-yu2qw02l 157 2 , , , cord-261058-yu2qw02l 157 3 68 68 CD cord-261058-yu2qw02l 157 4 , , , cord-261058-yu2qw02l 157 5 69 69 CD cord-261058-yu2qw02l 157 6 Whilst whilst IN cord-261058-yu2qw02l 157 7 this this DT cord-261058-yu2qw02l 157 8 may may MD cord-261058-yu2qw02l 157 9 be be VB cord-261058-yu2qw02l 157 10 partly partly RB cord-261058-yu2qw02l 157 11 attributable attributable JJ cord-261058-yu2qw02l 157 12 to to IN cord-261058-yu2qw02l 157 13 increased increase VBN cord-261058-yu2qw02l 157 14 awareness awareness NN cord-261058-yu2qw02l 157 15 , , , cord-261058-yu2qw02l 157 16 the the DT cord-261058-yu2qw02l 157 17 increasing increase VBG cord-261058-yu2qw02l 157 18 incidence incidence NN cord-261058-yu2qw02l 157 19 is be VBZ cord-261058-yu2qw02l 157 20 reported report VBN cord-261058-yu2qw02l 157 21 in in IN cord-261058-yu2qw02l 157 22 countries country NNS cord-261058-yu2qw02l 157 23 where where WRB cord-261058-yu2qw02l 157 24 the the DT cord-261058-yu2qw02l 157 25 disease disease NN cord-261058-yu2qw02l 157 26 has have VBZ cord-261058-yu2qw02l 157 27 been be VBN cord-261058-yu2qw02l 157 28 widely widely RB cord-261058-yu2qw02l 157 29 recognised recognise VBN cord-261058-yu2qw02l 157 30 for for IN cord-261058-yu2qw02l 157 31 several several JJ cord-261058-yu2qw02l 157 32 years year NNS cord-261058-yu2qw02l 157 33 and and CC cord-261058-yu2qw02l 157 34 where where WRB cord-261058-yu2qw02l 157 35 a a DT cord-261058-yu2qw02l 157 36 standard standard JJ cord-261058-yu2qw02l 157 37 case case NN cord-261058-yu2qw02l 157 38 definition definition NN cord-261058-yu2qw02l 157 39 is be VBZ cord-261058-yu2qw02l 157 40 employed employ VBN cord-261058-yu2qw02l 157 41 and and CC cord-261058-yu2qw02l 157 42 may may MD cord-261058-yu2qw02l 157 43 therefore therefore RB cord-261058-yu2qw02l 157 44 reflect reflect VB cord-261058-yu2qw02l 157 45 changing change VBG cord-261058-yu2qw02l 157 46 epidemiology epidemiology NN cord-261058-yu2qw02l 157 47 . . . cord-261058-yu2qw02l 158 1 The the DT cord-261058-yu2qw02l 158 2 incidence incidence NN cord-261058-yu2qw02l 158 3 of of IN cord-261058-yu2qw02l 158 4 KD KD NNP cord-261058-yu2qw02l 158 5 is be VBZ cord-261058-yu2qw02l 158 6 therefore therefore RB cord-261058-yu2qw02l 158 7 greatest great JJS cord-261058-yu2qw02l 158 8 in in IN cord-261058-yu2qw02l 158 9 north north NN cord-261058-yu2qw02l 158 10 - - HYPH cord-261058-yu2qw02l 158 11 east east NN cord-261058-yu2qw02l 158 12 Asians Asians NNPS cord-261058-yu2qw02l 158 13 , , , cord-261058-yu2qw02l 158 14 especially especially RB cord-261058-yu2qw02l 158 15 in in IN cord-261058-yu2qw02l 158 16 Koreans Koreans NNPS cord-261058-yu2qw02l 158 17 and and CC cord-261058-yu2qw02l 158 18 Japanese Japanese NNP cord-261058-yu2qw02l 158 19 . . . cord-261058-yu2qw02l 159 1 It -PRON- PRP cord-261058-yu2qw02l 159 2 is be VBZ cord-261058-yu2qw02l 159 3 estimated estimate VBN cord-261058-yu2qw02l 159 4 that that IN cord-261058-yu2qw02l 159 5 1 1 CD cord-261058-yu2qw02l 159 6 - - SYM cord-261058-yu2qw02l 159 7 2 2 CD cord-261058-yu2qw02l 159 8 % % NN cord-261058-yu2qw02l 159 9 of of IN cord-261058-yu2qw02l 159 10 all all DT cord-261058-yu2qw02l 159 11 hospitalised hospitalise VBN cord-261058-yu2qw02l 159 12 Korean korean JJ cord-261058-yu2qw02l 159 13 children child NNS cord-261058-yu2qw02l 159 14 have have VBP cord-261058-yu2qw02l 159 15 KD KD NNP cord-261058-yu2qw02l 159 16 ( ( -LRB- cord-261058-yu2qw02l 159 17 Park Park NNP cord-261058-yu2qw02l 159 18 YW YW NNP cord-261058-yu2qw02l 159 19 , , , cord-261058-yu2qw02l 159 20 personal personal JJ cord-261058-yu2qw02l 159 21 communication communication NN cord-261058-yu2qw02l 159 22 ) ) -RRB- cord-261058-yu2qw02l 159 23 and and CC cord-261058-yu2qw02l 159 24 that that IN cord-261058-yu2qw02l 159 25 KD KD NNP cord-261058-yu2qw02l 159 26 affects affect VBZ cord-261058-yu2qw02l 159 27 one one CD cord-261058-yu2qw02l 159 28 in in IN cord-261058-yu2qw02l 159 29 150 150 CD cord-261058-yu2qw02l 159 30 Japanese japanese JJ cord-261058-yu2qw02l 159 31 children child NNS cord-261058-yu2qw02l 159 32 . . . cord-261058-yu2qw02l 160 1 3 3 LS cord-261058-yu2qw02l 161 1 This this DT cord-261058-yu2qw02l 161 2 indicates indicate VBZ cord-261058-yu2qw02l 161 3 genetic genetic JJ cord-261058-yu2qw02l 161 4 factors factor NNS cord-261058-yu2qw02l 161 5 may may MD cord-261058-yu2qw02l 161 6 be be VB cord-261058-yu2qw02l 161 7 central central JJ cord-261058-yu2qw02l 161 8 in in IN cord-261058-yu2qw02l 161 9 determining determine VBG cord-261058-yu2qw02l 161 10 susceptibility susceptibility NN cord-261058-yu2qw02l 161 11 , , , cord-261058-yu2qw02l 161 12 especially especially RB cord-261058-yu2qw02l 161 13 as as IN cord-261058-yu2qw02l 161 14 the the DT cord-261058-yu2qw02l 161 15 incidence incidence NN cord-261058-yu2qw02l 161 16 rate rate NN cord-261058-yu2qw02l 161 17 remains remain VBZ cord-261058-yu2qw02l 161 18 high high JJ cord-261058-yu2qw02l 161 19 in in IN cord-261058-yu2qw02l 161 20 those those DT cord-261058-yu2qw02l 161 21 migrating migrate VBG cord-261058-yu2qw02l 161 22 to to TO cord-261058-yu2qw02l 161 23 lower lower VB cord-261058-yu2qw02l 161 24 incidence incidence NN cord-261058-yu2qw02l 161 25 countries country NNS cord-261058-yu2qw02l 161 26 . . . cord-261058-yu2qw02l 162 1 For for IN cord-261058-yu2qw02l 162 2 example example NN cord-261058-yu2qw02l 162 3 , , , cord-261058-yu2qw02l 162 4 the the DT cord-261058-yu2qw02l 162 5 incidence incidence NN cord-261058-yu2qw02l 162 6 of of IN cord-261058-yu2qw02l 162 7 KD KD NNP cord-261058-yu2qw02l 162 8 in in IN cord-261058-yu2qw02l 162 9 Japanese japanese JJ cord-261058-yu2qw02l 162 10 Americans Americans NNPS cord-261058-yu2qw02l 162 11 in in IN cord-261058-yu2qw02l 162 12 Hawaii Hawaii NNP cord-261058-yu2qw02l 162 13 ( ( -LRB- cord-261058-yu2qw02l 162 14 135/100,000 135/100,000 CD cord-261058-yu2qw02l 162 15 < < XX cord-261058-yu2qw02l 162 16 5 5 CD cord-261058-yu2qw02l 162 17 years year NNS cord-261058-yu2qw02l 162 18 ) ) -RRB- cord-261058-yu2qw02l 162 19 is be VBZ cord-261058-yu2qw02l 162 20 identical identical JJ cord-261058-yu2qw02l 162 21 to to IN cord-261058-yu2qw02l 162 22 the the DT cord-261058-yu2qw02l 162 23 highest high JJS cord-261058-yu2qw02l 162 24 rates rate NNS cord-261058-yu2qw02l 162 25 reported report VBN cord-261058-yu2qw02l 162 26 from from IN cord-261058-yu2qw02l 162 27 Japanese japanese JJ cord-261058-yu2qw02l 162 28 living live VBG cord-261058-yu2qw02l 162 29 in in IN cord-261058-yu2qw02l 162 30 Japan Japan NNP cord-261058-yu2qw02l 162 31 . . . cord-261058-yu2qw02l 163 1 67 67 CD cord-261058-yu2qw02l 164 1 The the DT cord-261058-yu2qw02l 164 2 incidence incidence NN cord-261058-yu2qw02l 164 3 rate rate NN cord-261058-yu2qw02l 164 4 in in IN cord-261058-yu2qw02l 164 5 siblings sibling NNS cord-261058-yu2qw02l 164 6 of of IN cord-261058-yu2qw02l 164 7 affected affected JJ cord-261058-yu2qw02l 164 8 children child NNS cord-261058-yu2qw02l 164 9 is be VBZ cord-261058-yu2qw02l 164 10 10 10 CD cord-261058-yu2qw02l 164 11 - - SYM cord-261058-yu2qw02l 164 12 15 15 CD cord-261058-yu2qw02l 164 13 fold fold VB cord-261058-yu2qw02l 164 14 higher higher RBR cord-261058-yu2qw02l 164 15 than than IN cord-261058-yu2qw02l 164 16 the the DT cord-261058-yu2qw02l 164 17 population population NN cord-261058-yu2qw02l 164 18 incidence incidence NN cord-261058-yu2qw02l 164 19 in in IN cord-261058-yu2qw02l 164 20 Japan Japan NNP cord-261058-yu2qw02l 164 21 . . . cord-261058-yu2qw02l 165 1 70 70 CD cord-261058-yu2qw02l 166 1 The the DT cord-261058-yu2qw02l 166 2 ratio ratio NN cord-261058-yu2qw02l 166 3 of of IN cord-261058-yu2qw02l 166 4 sibling sibling NN cord-261058-yu2qw02l 166 5 to to IN cord-261058-yu2qw02l 166 6 population population NN cord-261058-yu2qw02l 166 7 incidence incidence NN cord-261058-yu2qw02l 166 8 is be VBZ cord-261058-yu2qw02l 166 9 termed term VBN cord-261058-yu2qw02l 166 10 the the DT cord-261058-yu2qw02l 166 11 ' ' `` cord-261058-yu2qw02l 166 12 heritability heritability NN cord-261058-yu2qw02l 166 13 ' ' '' cord-261058-yu2qw02l 166 14 or or CC cord-261058-yu2qw02l 166 15 ' ' `` cord-261058-yu2qw02l 166 16 l l NNP cord-261058-yu2qw02l 166 17 s s NNP cord-261058-yu2qw02l 166 18 ' ' '' cord-261058-yu2qw02l 166 19 . . . cord-261058-yu2qw02l 167 1 Sibling sibling NN cord-261058-yu2qw02l 167 2 rates rate NNS cord-261058-yu2qw02l 167 3 outside outside IN cord-261058-yu2qw02l 167 4 Japan Japan NNP cord-261058-yu2qw02l 167 5 are be VBP cord-261058-yu2qw02l 167 6 unknown unknown JJ cord-261058-yu2qw02l 167 7 , , , cord-261058-yu2qw02l 167 8 but but CC cord-261058-yu2qw02l 167 9 reports report NNS cord-261058-yu2qw02l 167 10 from from IN cord-261058-yu2qw02l 167 11 Caucasians Caucasians NNPS cord-261058-yu2qw02l 167 12 support support VBP cord-261058-yu2qw02l 167 13 this this DT cord-261058-yu2qw02l 167 14 trend trend NN cord-261058-yu2qw02l 167 15 71 71 CD cord-261058-yu2qw02l 167 16 and and CC cord-261058-yu2qw02l 167 17 sibling sibling NN cord-261058-yu2qw02l 167 18 rates rate NNS cord-261058-yu2qw02l 167 19 in in IN cord-261058-yu2qw02l 167 20 Korea Korea NNP cord-261058-yu2qw02l 167 21 37 37 CD cord-261058-yu2qw02l 168 1 ( ( -LRB- cord-261058-yu2qw02l 168 2 Burgner Burgner NNP cord-261058-yu2qw02l 168 3 , , , cord-261058-yu2qw02l 168 4 unpublished unpublished JJ cord-261058-yu2qw02l 168 5 observations observation NNS cord-261058-yu2qw02l 168 6 ) ) -RRB- cord-261058-yu2qw02l 168 7 also also RB cord-261058-yu2qw02l 168 8 support support VBP cord-261058-yu2qw02l 168 9 this this DT cord-261058-yu2qw02l 168 10 high high JJ cord-261058-yu2qw02l 168 11 heritability heritability NN cord-261058-yu2qw02l 168 12 . . . cord-261058-yu2qw02l 169 1 This this DT cord-261058-yu2qw02l 169 2 figure figure NN cord-261058-yu2qw02l 169 3 is be VBZ cord-261058-yu2qw02l 169 4 slightly slightly RB cord-261058-yu2qw02l 169 5 less less JJR cord-261058-yu2qw02l 169 6 than than IN cord-261058-yu2qw02l 169 7 the the DT cord-261058-yu2qw02l 169 8 heritability heritability NN cord-261058-yu2qw02l 169 9 for for IN cord-261058-yu2qw02l 169 10 insulin insulin NN cord-261058-yu2qw02l 169 11 - - HYPH cord-261058-yu2qw02l 169 12 dependent dependent JJ cord-261058-yu2qw02l 169 13 diabetes diabetes NN cord-261058-yu2qw02l 170 1 ( ( -LRB- cord-261058-yu2qw02l 170 2 l l NNP cord-261058-yu2qw02l 170 3 s s NNP cord-261058-yu2qw02l 170 4 15 15 CD cord-261058-yu2qw02l 170 5 ) ) -RRB- cord-261058-yu2qw02l 170 6 and and CC cord-261058-yu2qw02l 170 7 4 4 CD cord-261058-yu2qw02l 170 8 times time NNS cord-261058-yu2qw02l 170 9 higher high JJR cord-261058-yu2qw02l 170 10 than than IN cord-261058-yu2qw02l 170 11 that that DT cord-261058-yu2qw02l 170 12 of of IN cord-261058-yu2qw02l 170 13 asthma asthma NN cord-261058-yu2qw02l 170 14 , , , cord-261058-yu2qw02l 170 15 72 72 CD cord-261058-yu2qw02l 170 16 suggesting suggest VBG cord-261058-yu2qw02l 170 17 a a DT cord-261058-yu2qw02l 170 18 striking striking JJ cord-261058-yu2qw02l 170 19 genetic genetic JJ cord-261058-yu2qw02l 170 20 predisposition predisposition NN cord-261058-yu2qw02l 170 21 to to TO cord-261058-yu2qw02l 170 22 develop develop VB cord-261058-yu2qw02l 170 23 the the DT cord-261058-yu2qw02l 170 24 disease disease NN cord-261058-yu2qw02l 170 25 in in IN cord-261058-yu2qw02l 170 26 a a DT cord-261058-yu2qw02l 170 27 minority minority NN cord-261058-yu2qw02l 170 28 of of IN cord-261058-yu2qw02l 170 29 children child NNS cord-261058-yu2qw02l 170 30 across across IN cord-261058-yu2qw02l 170 31 different different JJ cord-261058-yu2qw02l 170 32 ethnic ethnic JJ cord-261058-yu2qw02l 170 33 groups group NNS cord-261058-yu2qw02l 170 34 . . . cord-261058-yu2qw02l 171 1 In in IN cord-261058-yu2qw02l 171 2 addition addition NN cord-261058-yu2qw02l 171 3 , , , cord-261058-yu2qw02l 171 4 the the DT cord-261058-yu2qw02l 171 5 incidence incidence NN cord-261058-yu2qw02l 171 6 of of IN cord-261058-yu2qw02l 171 7 previous previous JJ cord-261058-yu2qw02l 171 8 KD KD NNP cord-261058-yu2qw02l 171 9 in in IN cord-261058-yu2qw02l 171 10 parents parent NNS cord-261058-yu2qw02l 171 11 of of IN cord-261058-yu2qw02l 171 12 Japanese japanese JJ cord-261058-yu2qw02l 171 13 children child NNS cord-261058-yu2qw02l 171 14 with with IN cord-261058-yu2qw02l 171 15 KD KD NNP cord-261058-yu2qw02l 171 16 is be VBZ cord-261058-yu2qw02l 171 17 significantly significantly RB cord-261058-yu2qw02l 171 18 increased increase VBN cord-261058-yu2qw02l 171 19 and and CC cord-261058-yu2qw02l 171 20 these these DT cord-261058-yu2qw02l 171 21 families family NNS cord-261058-yu2qw02l 171 22 are be VBP cord-261058-yu2qw02l 171 23 much much RB cord-261058-yu2qw02l 171 24 more more RBR cord-261058-yu2qw02l 171 25 likely likely JJ cord-261058-yu2qw02l 171 26 to to TO cord-261058-yu2qw02l 171 27 have have VB cord-261058-yu2qw02l 171 28 other other JJ cord-261058-yu2qw02l 171 29 affected affected JJ cord-261058-yu2qw02l 171 30 children child NNS cord-261058-yu2qw02l 171 31 and and CC cord-261058-yu2qw02l 171 32 children child NNS cord-261058-yu2qw02l 171 33 with with IN cord-261058-yu2qw02l 171 34 recurrent recurrent JJ cord-261058-yu2qw02l 171 35 disease disease NN cord-261058-yu2qw02l 171 36 . . . cord-261058-yu2qw02l 172 1 73 73 CD cord-261058-yu2qw02l 172 2 Taken take VBN cord-261058-yu2qw02l 172 3 together together RB cord-261058-yu2qw02l 172 4 , , , cord-261058-yu2qw02l 172 5 these these DT cord-261058-yu2qw02l 172 6 epidemiological epidemiological JJ cord-261058-yu2qw02l 172 7 data datum NNS cord-261058-yu2qw02l 172 8 provide provide VBP cord-261058-yu2qw02l 172 9 convincing convincing JJ cord-261058-yu2qw02l 172 10 evidence evidence NN cord-261058-yu2qw02l 172 11 for for IN cord-261058-yu2qw02l 172 12 a a DT cord-261058-yu2qw02l 172 13 major major JJ cord-261058-yu2qw02l 172 14 role role NN cord-261058-yu2qw02l 172 15 for for IN cord-261058-yu2qw02l 172 16 host host NN cord-261058-yu2qw02l 172 17 genetics genetic NNS cord-261058-yu2qw02l 172 18 in in IN cord-261058-yu2qw02l 172 19 KD KD NNP cord-261058-yu2qw02l 172 20 susceptibility susceptibility NN cord-261058-yu2qw02l 172 21 . . . cord-261058-yu2qw02l 173 1 Whilst whilst IN cord-261058-yu2qw02l 173 2 there there EX cord-261058-yu2qw02l 173 3 are be VBP cord-261058-yu2qw02l 173 4 concerns concern NNS cord-261058-yu2qw02l 173 5 that that IN cord-261058-yu2qw02l 173 6 cardiovascular cardiovascular JJ cord-261058-yu2qw02l 173 7 damage damage NN cord-261058-yu2qw02l 173 8 may may MD cord-261058-yu2qw02l 173 9 be be VB cord-261058-yu2qw02l 173 10 pervasive pervasive JJ cord-261058-yu2qw02l 173 11 in in IN cord-261058-yu2qw02l 173 12 KD KD NNP cord-261058-yu2qw02l 173 13 , , , cord-261058-yu2qw02l 173 14 overt overt JJ cord-261058-yu2qw02l 173 15 coronary coronary JJ cord-261058-yu2qw02l 173 16 artery artery NN cord-261058-yu2qw02l 173 17 lesions lesion NNS cord-261058-yu2qw02l 173 18 only only RB cord-261058-yu2qw02l 173 19 develop develop VBP cord-261058-yu2qw02l 173 20 in in IN cord-261058-yu2qw02l 173 21 a a DT cord-261058-yu2qw02l 173 22 minority minority NN cord-261058-yu2qw02l 173 23 of of IN cord-261058-yu2qw02l 173 24 children child NNS cord-261058-yu2qw02l 173 25 . . . cord-261058-yu2qw02l 174 1 In in IN cord-261058-yu2qw02l 174 2 acute acute JJ cord-261058-yu2qw02l 174 3 KD KD NNP cord-261058-yu2qw02l 174 4 all all DT cord-261058-yu2qw02l 174 5 arms arm NNS cord-261058-yu2qw02l 174 6 of of IN cord-261058-yu2qw02l 174 7 the the DT cord-261058-yu2qw02l 174 8 innate innate JJ cord-261058-yu2qw02l 174 9 and and CC cord-261058-yu2qw02l 174 10 adaptive adaptive JJ cord-261058-yu2qw02l 174 11 immune immune JJ cord-261058-yu2qw02l 174 12 response response NN cord-261058-yu2qw02l 174 13 are be VBP cord-261058-yu2qw02l 174 14 activated activate VBN cord-261058-yu2qw02l 174 15 , , , cord-261058-yu2qw02l 174 16 but but CC cord-261058-yu2qw02l 174 17 lymphocytes lymphocyte NNS cord-261058-yu2qw02l 174 18 , , , cord-261058-yu2qw02l 174 19 macrophages macrophage NNS cord-261058-yu2qw02l 174 20 and and CC cord-261058-yu2qw02l 174 21 neutrophils neutrophil NNS cord-261058-yu2qw02l 174 22 are be VBP cord-261058-yu2qw02l 174 23 central central JJ cord-261058-yu2qw02l 174 24 . . . cord-261058-yu2qw02l 175 1 74 74 CD cord-261058-yu2qw02l 176 1 The the DT cord-261058-yu2qw02l 176 2 extent extent NN cord-261058-yu2qw02l 176 3 and and CC cord-261058-yu2qw02l 176 4 kinetics kinetic NNS cord-261058-yu2qw02l 176 5 of of IN cord-261058-yu2qw02l 176 6 host host NN cord-261058-yu2qw02l 176 7 inflammation inflammation NN cord-261058-yu2qw02l 176 8 strongly strongly RB cord-261058-yu2qw02l 176 9 correlates correlate VBZ cord-261058-yu2qw02l 176 10 with with IN cord-261058-yu2qw02l 176 11 the the DT cord-261058-yu2qw02l 176 12 risk risk NN cord-261058-yu2qw02l 176 13 of of IN cord-261058-yu2qw02l 176 14 coronary coronary JJ cord-261058-yu2qw02l 176 15 damage damage NN cord-261058-yu2qw02l 176 16 . . . cord-261058-yu2qw02l 177 1 The the DT cord-261058-yu2qw02l 177 2 duration duration NN cord-261058-yu2qw02l 177 3 of of IN cord-261058-yu2qw02l 177 4 fever fever NN cord-261058-yu2qw02l 177 5 prior prior RB cord-261058-yu2qw02l 177 6 to to IN cord-261058-yu2qw02l 177 7 treatment treatment NN cord-261058-yu2qw02l 177 8 , , , cord-261058-yu2qw02l 177 9 75 75 CD cord-261058-yu2qw02l 177 10 - - SYM cord-261058-yu2qw02l 177 11 77 77 CD cord-261058-yu2qw02l 177 12 the the DT cord-261058-yu2qw02l 177 13 maximal maximal JJ cord-261058-yu2qw02l 177 14 erythrocyte erythrocyte NN cord-261058-yu2qw02l 177 15 sedimentation sedimentation NN cord-261058-yu2qw02l 177 16 rate rate NN cord-261058-yu2qw02l 177 17 , , , cord-261058-yu2qw02l 177 18 78 78 CD cord-261058-yu2qw02l 177 19 the the DT cord-261058-yu2qw02l 177 20 extent extent NN cord-261058-yu2qw02l 177 21 of of IN cord-261058-yu2qw02l 177 22 pro pro JJ cord-261058-yu2qw02l 177 23 - - JJ cord-261058-yu2qw02l 177 24 inflammatory inflammatory JJ cord-261058-yu2qw02l 177 25 cytokine cytokine NN cord-261058-yu2qw02l 177 26 production production NN cord-261058-yu2qw02l 177 27 79 79 CD cord-261058-yu2qw02l 177 28 , , , cord-261058-yu2qw02l 177 29 80 80 CD cord-261058-yu2qw02l 177 30 and and CC cord-261058-yu2qw02l 177 31 the the DT cord-261058-yu2qw02l 177 32 degree degree NN cord-261058-yu2qw02l 177 33 of of IN cord-261058-yu2qw02l 177 34 neutrophil neutrophil NN cord-261058-yu2qw02l 177 35 activation activation NN cord-261058-yu2qw02l 177 36 81 81 CD cord-261058-yu2qw02l 177 37 have have VBP cord-261058-yu2qw02l 177 38 all all DT cord-261058-yu2qw02l 177 39 been be VBN cord-261058-yu2qw02l 177 40 shown show VBN cord-261058-yu2qw02l 177 41 to to TO cord-261058-yu2qw02l 177 42 be be VB cord-261058-yu2qw02l 177 43 risk risk NN cord-261058-yu2qw02l 177 44 factors factor NNS cord-261058-yu2qw02l 177 45 for for IN cord-261058-yu2qw02l 177 46 coronary coronary JJ cord-261058-yu2qw02l 177 47 damage damage NN cord-261058-yu2qw02l 177 48 . . . cord-261058-yu2qw02l 178 1 The the DT cord-261058-yu2qw02l 178 2 extent extent NN cord-261058-yu2qw02l 178 3 of of IN cord-261058-yu2qw02l 178 4 the the DT cord-261058-yu2qw02l 178 5 host host NN cord-261058-yu2qw02l 178 6 inflammatory inflammatory JJ cord-261058-yu2qw02l 178 7 response response NN cord-261058-yu2qw02l 178 8 is be VBZ cord-261058-yu2qw02l 178 9 partly partly RB cord-261058-yu2qw02l 178 10 genetically genetically RB cord-261058-yu2qw02l 178 11 determined determined JJ cord-261058-yu2qw02l 178 12 . . . cord-261058-yu2qw02l 179 1 82 82 CD cord-261058-yu2qw02l 179 2 Genetic genetic JJ cord-261058-yu2qw02l 179 3 factors factor NNS cord-261058-yu2qw02l 179 4 are be VBP cord-261058-yu2qw02l 179 5 therefore therefore RB cord-261058-yu2qw02l 179 6 likely likely JJ cord-261058-yu2qw02l 179 7 to to TO cord-261058-yu2qw02l 179 8 be be VB cord-261058-yu2qw02l 179 9 important important JJ cord-261058-yu2qw02l 179 10 in in IN cord-261058-yu2qw02l 179 11 determining determine VBG cord-261058-yu2qw02l 179 12 outcome outcome NN cord-261058-yu2qw02l 179 13 in in IN cord-261058-yu2qw02l 179 14 KD KD NNP cord-261058-yu2qw02l 179 15 and and CC cord-261058-yu2qw02l 179 16 genetic genetic JJ cord-261058-yu2qw02l 179 17 studies study NNS cord-261058-yu2qw02l 179 18 may may MD cord-261058-yu2qw02l 179 19 identify identify VB cord-261058-yu2qw02l 179 20 key key JJ cord-261058-yu2qw02l 179 21 pathogenic pathogenic JJ cord-261058-yu2qw02l 179 22 mediators mediator NNS cord-261058-yu2qw02l 179 23 and and CC cord-261058-yu2qw02l 179 24 ultimately ultimately RB cord-261058-yu2qw02l 179 25 guide guide VB cord-261058-yu2qw02l 179 26 the the DT cord-261058-yu2qw02l 179 27 development development NN cord-261058-yu2qw02l 179 28 of of IN cord-261058-yu2qw02l 179 29 new new JJ cord-261058-yu2qw02l 179 30 interventions intervention NNS cord-261058-yu2qw02l 179 31 . . . cord-261058-yu2qw02l 180 1 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 180 2 disease disease NN cord-261058-yu2qw02l 180 3 is be VBZ cord-261058-yu2qw02l 180 4 likely likely JJ cord-261058-yu2qw02l 180 5 to to TO cord-261058-yu2qw02l 180 6 be be VB cord-261058-yu2qw02l 180 7 a a DT cord-261058-yu2qw02l 180 8 genetically genetically RB cord-261058-yu2qw02l 180 9 ' ' `` cord-261058-yu2qw02l 180 10 complex complex JJ cord-261058-yu2qw02l 180 11 disease disease NN cord-261058-yu2qw02l 180 12 ' ' '' cord-261058-yu2qw02l 180 13 , , , cord-261058-yu2qw02l 180 14 with with IN cord-261058-yu2qw02l 180 15 contributions contribution NNS cord-261058-yu2qw02l 180 16 from from IN cord-261058-yu2qw02l 180 17 a a DT cord-261058-yu2qw02l 180 18 number number NN cord-261058-yu2qw02l 180 19 of of IN cord-261058-yu2qw02l 180 20 genetic genetic JJ cord-261058-yu2qw02l 180 21 loci locus NNS cord-261058-yu2qw02l 180 22 to to IN cord-261058-yu2qw02l 180 23 susceptibility susceptibility NN cord-261058-yu2qw02l 180 24 and and CC cord-261058-yu2qw02l 180 25 outcome outcome NN cord-261058-yu2qw02l 180 26 . . . cord-261058-yu2qw02l 181 1 Associations association NNS cord-261058-yu2qw02l 181 2 between between IN cord-261058-yu2qw02l 181 3 genetic genetic JJ cord-261058-yu2qw02l 181 4 variants variant NNS cord-261058-yu2qw02l 181 5 at at IN cord-261058-yu2qw02l 181 6 candidate candidate NN cord-261058-yu2qw02l 181 7 loci locus NNS cord-261058-yu2qw02l 181 8 and and CC cord-261058-yu2qw02l 181 9 KD KD NNP cord-261058-yu2qw02l 181 10 susceptibility susceptibility NN cord-261058-yu2qw02l 181 11 and and CC cord-261058-yu2qw02l 181 12 outcome outcome NN cord-261058-yu2qw02l 181 13 may may MD cord-261058-yu2qw02l 181 14 be be VB cord-261058-yu2qw02l 181 15 extremely extremely RB cord-261058-yu2qw02l 181 16 informative informative JJ cord-261058-yu2qw02l 181 17 about about IN cord-261058-yu2qw02l 181 18 the the DT cord-261058-yu2qw02l 181 19 role role NN cord-261058-yu2qw02l 181 20 of of IN cord-261058-yu2qw02l 181 21 specific specific JJ cord-261058-yu2qw02l 181 22 mediators mediator NNS cord-261058-yu2qw02l 181 23 in in IN cord-261058-yu2qw02l 181 24 etiopathogenesis etiopathogenesis NNP cord-261058-yu2qw02l 181 25 , , , cord-261058-yu2qw02l 181 26 allowing allow VBG cord-261058-yu2qw02l 181 27 investigation investigation NN cord-261058-yu2qw02l 181 28 of of IN cord-261058-yu2qw02l 181 29 hypotheses hypothesis NNS cord-261058-yu2qw02l 181 30 suggested suggest VBN cord-261058-yu2qw02l 181 31 by by IN cord-261058-yu2qw02l 181 32 the the DT cord-261058-yu2qw02l 181 33 clinical clinical JJ cord-261058-yu2qw02l 181 34 data datum NNS cord-261058-yu2qw02l 181 35 , , , cord-261058-yu2qw02l 181 36 but but CC cord-261058-yu2qw02l 181 37 untestable untestable JJ cord-261058-yu2qw02l 181 38 by by IN cord-261058-yu2qw02l 181 39 conventional conventional JJ cord-261058-yu2qw02l 181 40 clinical clinical JJ cord-261058-yu2qw02l 181 41 or or CC cord-261058-yu2qw02l 181 42 laboratory laboratory NN cord-261058-yu2qw02l 181 43 studies study NNS cord-261058-yu2qw02l 181 44 . . . cord-261058-yu2qw02l 182 1 The the DT cord-261058-yu2qw02l 182 2 consensus consensus NN cord-261058-yu2qw02l 182 3 view view NN cord-261058-yu2qw02l 182 4 supports support VBZ cord-261058-yu2qw02l 182 5 the the DT cord-261058-yu2qw02l 182 6 concept concept NN cord-261058-yu2qw02l 182 7 of of IN cord-261058-yu2qw02l 182 8 a a DT cord-261058-yu2qw02l 182 9 genetically genetically RB cord-261058-yu2qw02l 182 10 - - HYPH cord-261058-yu2qw02l 182 11 susceptible susceptible JJ cord-261058-yu2qw02l 182 12 host host NN cord-261058-yu2qw02l 182 13 in in IN cord-261058-yu2qw02l 182 14 KD KD NNP cord-261058-yu2qw02l 182 15 6 6 CD cord-261058-yu2qw02l 182 16 , , , cord-261058-yu2qw02l 182 17 83 83 CD cord-261058-yu2qw02l 182 18 and and CC cord-261058-yu2qw02l 182 19 there there EX cord-261058-yu2qw02l 182 20 is be VBZ cord-261058-yu2qw02l 182 21 growing grow VBG cord-261058-yu2qw02l 182 22 realisation realisation NN cord-261058-yu2qw02l 182 23 that that IN cord-261058-yu2qw02l 182 24 immunogenetic immunogenetic JJ cord-261058-yu2qw02l 182 25 studies study NNS cord-261058-yu2qw02l 182 26 may may MD cord-261058-yu2qw02l 182 27 reveal reveal VB cord-261058-yu2qw02l 182 28 much much JJ cord-261058-yu2qw02l 182 29 about about IN cord-261058-yu2qw02l 182 30 the the DT cord-261058-yu2qw02l 182 31 disease disease NN cord-261058-yu2qw02l 182 32 and and CC cord-261058-yu2qw02l 182 33 improve improve VB cord-261058-yu2qw02l 182 34 diagnosis diagnosis NN cord-261058-yu2qw02l 182 35 , , , cord-261058-yu2qw02l 182 36 treatment treatment NN cord-261058-yu2qw02l 182 37 and and CC cord-261058-yu2qw02l 182 38 prognosis prognosis NN cord-261058-yu2qw02l 182 39 . . . cord-261058-yu2qw02l 183 1 Immunogenetic immunogenetic JJ cord-261058-yu2qw02l 183 2 data datum NNS cord-261058-yu2qw02l 183 3 suggest suggest VBP cord-261058-yu2qw02l 183 4 a a DT cord-261058-yu2qw02l 183 5 number number NN cord-261058-yu2qw02l 183 6 of of IN cord-261058-yu2qw02l 183 7 plausible plausible JJ cord-261058-yu2qw02l 183 8 associations association NNS cord-261058-yu2qw02l 183 9 . . . cord-261058-yu2qw02l 184 1 Many many JJ cord-261058-yu2qw02l 184 2 studies study NNS cord-261058-yu2qw02l 184 3 focus focus VBP cord-261058-yu2qw02l 184 4 on on IN cord-261058-yu2qw02l 184 5 putative putative JJ cord-261058-yu2qw02l 184 6 downstream downstream JJ cord-261058-yu2qw02l 184 7 outcome outcome NN cord-261058-yu2qw02l 184 8 determinants determinant NNS cord-261058-yu2qw02l 184 9 and and CC cord-261058-yu2qw02l 184 10 suggest suggest VBP cord-261058-yu2qw02l 184 11 a a DT cord-261058-yu2qw02l 184 12 role role NN cord-261058-yu2qw02l 184 13 for for IN cord-261058-yu2qw02l 184 14 mediators mediator NNS cord-261058-yu2qw02l 184 15 of of IN cord-261058-yu2qw02l 184 16 innate innate JJ cord-261058-yu2qw02l 184 17 inflammation inflammation NN cord-261058-yu2qw02l 184 18 , , , cord-261058-yu2qw02l 184 19 84 84 CD cord-261058-yu2qw02l 184 20 endothelial endothelial JJ cord-261058-yu2qw02l 184 21 activation activation NN cord-261058-yu2qw02l 184 22 85 85 CD cord-261058-yu2qw02l 184 23 and and CC cord-261058-yu2qw02l 184 24 cardiovascular cardiovascular JJ cord-261058-yu2qw02l 184 25 homeostasis homeostasis NN cord-261058-yu2qw02l 184 26 . . . cord-261058-yu2qw02l 185 1 86 86 CD cord-261058-yu2qw02l 185 2 Studies study NNS cord-261058-yu2qw02l 185 3 of of IN cord-261058-yu2qw02l 185 4 susceptibility susceptibility NN cord-261058-yu2qw02l 185 5 determinants determinant NNS cord-261058-yu2qw02l 185 6 are be VBP cord-261058-yu2qw02l 185 7 more more RBR cord-261058-yu2qw02l 185 8 limited limited JJ cord-261058-yu2qw02l 185 9 . . . cord-261058-yu2qw02l 186 1 There there EX cord-261058-yu2qw02l 186 2 are be VBP cord-261058-yu2qw02l 186 3 associations association NNS cord-261058-yu2qw02l 186 4 with with IN cord-261058-yu2qw02l 186 5 class class NN cord-261058-yu2qw02l 187 1 I -PRON- PRP cord-261058-yu2qw02l 187 2 regions region NNS cord-261058-yu2qw02l 187 3 of of IN cord-261058-yu2qw02l 187 4 the the DT cord-261058-yu2qw02l 187 5 Human Human NNP cord-261058-yu2qw02l 187 6 Leucocyte Leucocyte NNP cord-261058-yu2qw02l 187 7 Antigen Antigen NNP cord-261058-yu2qw02l 187 8 ( ( -LRB- cord-261058-yu2qw02l 187 9 HLA HLA NNP cord-261058-yu2qw02l 187 10 ) ) -RRB- cord-261058-yu2qw02l 187 11 in in IN cord-261058-yu2qw02l 187 12 Japanese Japanese NNP cord-261058-yu2qw02l 187 13 , , , cord-261058-yu2qw02l 187 14 87 87 CD cord-261058-yu2qw02l 187 15 with with IN cord-261058-yu2qw02l 187 16 different different JJ cord-261058-yu2qw02l 187 17 alleles allele NNS cord-261058-yu2qw02l 187 18 associated associate VBN cord-261058-yu2qw02l 187 19 in in IN cord-261058-yu2qw02l 187 20 Caucasians Caucasians NNPS cord-261058-yu2qw02l 187 21 . . . cord-261058-yu2qw02l 188 1 88 88 CD cord-261058-yu2qw02l 189 1 However however RB cord-261058-yu2qw02l 189 2 , , , cord-261058-yu2qw02l 189 3 these these DT cord-261058-yu2qw02l 189 4 HLA HLA NNP cord-261058-yu2qw02l 189 5 studies study NNS cord-261058-yu2qw02l 189 6 are be VBP cord-261058-yu2qw02l 189 7 largely largely RB cord-261058-yu2qw02l 189 8 historical historical JJ cord-261058-yu2qw02l 189 9 and and CC cord-261058-yu2qw02l 189 10 further further JJ cord-261058-yu2qw02l 189 11 work work NN cord-261058-yu2qw02l 189 12 using use VBG cord-261058-yu2qw02l 189 13 modern modern JJ cord-261058-yu2qw02l 189 14 HLA HLA NNP cord-261058-yu2qw02l 189 15 typing typing NN cord-261058-yu2qw02l 189 16 techniques technique NNS cord-261058-yu2qw02l 189 17 are be VBP cord-261058-yu2qw02l 189 18 warranted warrant VBN cord-261058-yu2qw02l 189 19 . . . cord-261058-yu2qw02l 190 1 Unfortunately unfortunately RB cord-261058-yu2qw02l 190 2 , , , cord-261058-yu2qw02l 190 3 genetic genetic JJ cord-261058-yu2qw02l 190 4 studies study NNS cord-261058-yu2qw02l 190 5 of of IN cord-261058-yu2qw02l 190 6 KD KD NNP cord-261058-yu2qw02l 190 7 have have VBP cord-261058-yu2qw02l 190 8 often often RB cord-261058-yu2qw02l 190 9 been be VBN cord-261058-yu2qw02l 190 10 undermined undermine VBN cord-261058-yu2qw02l 190 11 by by IN cord-261058-yu2qw02l 190 12 methodological methodological JJ cord-261058-yu2qw02l 190 13 problems problem NNS cord-261058-yu2qw02l 190 14 89 89 CD cord-261058-yu2qw02l 190 15 that that DT cord-261058-yu2qw02l 190 16 dog dog NN cord-261058-yu2qw02l 190 17 many many JJ cord-261058-yu2qw02l 190 18 such such JJ cord-261058-yu2qw02l 190 19 studies study NNS cord-261058-yu2qw02l 190 20 of of IN cord-261058-yu2qw02l 190 21 human human JJ cord-261058-yu2qw02l 190 22 complex complex JJ cord-261058-yu2qw02l 190 23 disease disease NN cord-261058-yu2qw02l 190 24 . . . cord-261058-yu2qw02l 191 1 Thus thus RB cord-261058-yu2qw02l 191 2 some some DT cord-261058-yu2qw02l 191 3 of of IN cord-261058-yu2qw02l 191 4 the the DT cord-261058-yu2qw02l 191 5 reported report VBN cord-261058-yu2qw02l 191 6 associations association NNS cord-261058-yu2qw02l 191 7 are be VBP cord-261058-yu2qw02l 191 8 likely likely JJ cord-261058-yu2qw02l 191 9 to to TO cord-261058-yu2qw02l 191 10 be be VB cord-261058-yu2qw02l 191 11 false false JJ cord-261058-yu2qw02l 191 12 positive positive JJ cord-261058-yu2qw02l 191 13 results result NNS cord-261058-yu2qw02l 191 14 . . . cord-261058-yu2qw02l 192 1 In in IN cord-261058-yu2qw02l 192 2 particular particular JJ cord-261058-yu2qw02l 192 3 , , , cord-261058-yu2qw02l 192 4 the the DT cord-261058-yu2qw02l 192 5 studies study NNS cord-261058-yu2qw02l 192 6 often often RB cord-261058-yu2qw02l 192 7 lack lack VBP cord-261058-yu2qw02l 192 8 statistical statistical JJ cord-261058-yu2qw02l 192 9 power power NN cord-261058-yu2qw02l 192 10 , , , cord-261058-yu2qw02l 192 11 employ employ VB cord-261058-yu2qw02l 192 12 multiple multiple JJ cord-261058-yu2qw02l 192 13 uncorrected uncorrected JJ cord-261058-yu2qw02l 192 14 statistical statistical JJ cord-261058-yu2qw02l 192 15 comparisons comparison NNS cord-261058-yu2qw02l 192 16 and and CC cord-261058-yu2qw02l 192 17 many many JJ cord-261058-yu2qw02l 192 18 do do VBP cord-261058-yu2qw02l 192 19 not not RB cord-261058-yu2qw02l 192 20 replicate replicate VB cord-261058-yu2qw02l 192 21 findings finding NNS cord-261058-yu2qw02l 192 22 in in IN cord-261058-yu2qw02l 192 23 an an DT cord-261058-yu2qw02l 192 24 independent independent JJ cord-261058-yu2qw02l 192 25 population population NN cord-261058-yu2qw02l 192 26 . . . cord-261058-yu2qw02l 193 1 87 87 CD cord-261058-yu2qw02l 193 2 , , , cord-261058-yu2qw02l 193 3 88 88 CD cord-261058-yu2qw02l 193 4 , , , cord-261058-yu2qw02l 193 5 [ [ -LRB- cord-261058-yu2qw02l 193 6 90 90 CD cord-261058-yu2qw02l 193 7 ] ] -RRB- cord-261058-yu2qw02l 193 8 [ [ -LRB- cord-261058-yu2qw02l 193 9 91 91 CD cord-261058-yu2qw02l 193 10 ] ] -RRB- cord-261058-yu2qw02l 193 11 [ [ -LRB- cord-261058-yu2qw02l 193 12 92 92 CD cord-261058-yu2qw02l 193 13 ] ] -RRB- cord-261058-yu2qw02l 193 14 Case case NN cord-261058-yu2qw02l 193 15 - - HYPH cord-261058-yu2qw02l 193 16 control control NN cord-261058-yu2qw02l 193 17 methodology methodology NN cord-261058-yu2qw02l 193 18 in in IN cord-261058-yu2qw02l 193 19 a a DT cord-261058-yu2qw02l 193 20 multi multi JJ cord-261058-yu2qw02l 193 21 - - JJ cord-261058-yu2qw02l 193 22 ethnic ethnic JJ cord-261058-yu2qw02l 193 23 disease disease NN cord-261058-yu2qw02l 193 24 may may MD cord-261058-yu2qw02l 193 25 yield yield VB cord-261058-yu2qw02l 193 26 spurious spurious JJ cord-261058-yu2qw02l 193 27 disease disease NN cord-261058-yu2qw02l 193 28 associations association NNS cord-261058-yu2qw02l 193 29 ( ( -LRB- cord-261058-yu2qw02l 193 30 type type NN cord-261058-yu2qw02l 193 31 I -PRON- PRP cord-261058-yu2qw02l 193 32 errors error NNS cord-261058-yu2qw02l 193 33 ) ) -RRB- cord-261058-yu2qw02l 193 34 due due IN cord-261058-yu2qw02l 193 35 to to IN cord-261058-yu2qw02l 193 36 population population NN cord-261058-yu2qw02l 193 37 admixture admixture NN cord-261058-yu2qw02l 193 38 , , , cord-261058-yu2qw02l 193 39 93 93 CD cord-261058-yu2qw02l 193 40 unless unless IN cord-261058-yu2qw02l 193 41 this this DT cord-261058-yu2qw02l 193 42 is be VBZ cord-261058-yu2qw02l 193 43 actively actively RB cord-261058-yu2qw02l 193 44 identified identify VBN cord-261058-yu2qw02l 193 45 . . . cord-261058-yu2qw02l 194 1 94 94 CD cord-261058-yu2qw02l 194 2 Inadequate inadequate JJ cord-261058-yu2qw02l 194 3 marker marker NN cord-261058-yu2qw02l 194 4 density density NN cord-261058-yu2qw02l 194 5 in in IN cord-261058-yu2qw02l 194 6 candidate candidate NN cord-261058-yu2qw02l 194 7 loci locus NNS cord-261058-yu2qw02l 194 8 , , , cord-261058-yu2qw02l 194 9 where where WRB cord-261058-yu2qw02l 194 10 the the DT cord-261058-yu2qw02l 194 11 functional functional JJ cord-261058-yu2qw02l 194 12 variants variant NNS cord-261058-yu2qw02l 194 13 are be VBP cord-261058-yu2qw02l 194 14 unknown unknown JJ cord-261058-yu2qw02l 194 15 , , , cord-261058-yu2qw02l 194 16 may may MD cord-261058-yu2qw02l 194 17 increase increase VB cord-261058-yu2qw02l 194 18 type type NN cord-261058-yu2qw02l 194 19 II ii CD cord-261058-yu2qw02l 194 20 errors error NNS cord-261058-yu2qw02l 194 21 . . . cord-261058-yu2qw02l 195 1 89 89 CD cord-261058-yu2qw02l 195 2 _SP cord-261058-yu2qw02l 196 1 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 196 2 disease disease NN cord-261058-yu2qw02l 196 3 is be VBZ cord-261058-yu2qw02l 196 4 a a DT cord-261058-yu2qw02l 196 5 fascinating fascinating JJ cord-261058-yu2qw02l 196 6 and and CC cord-261058-yu2qw02l 196 7 important important JJ cord-261058-yu2qw02l 196 8 paediatric paediatric JJ cord-261058-yu2qw02l 196 9 illness illness NN cord-261058-yu2qw02l 196 10 , , , cord-261058-yu2qw02l 196 11 which which WDT cord-261058-yu2qw02l 196 12 presents present VBZ cord-261058-yu2qw02l 196 13 a a DT cord-261058-yu2qw02l 196 14 significant significant JJ cord-261058-yu2qw02l 196 15 diagnostic diagnostic JJ cord-261058-yu2qw02l 196 16 challenge challenge NN cord-261058-yu2qw02l 196 17 . . . cord-261058-yu2qw02l 197 1 It -PRON- PRP cord-261058-yu2qw02l 197 2 is be VBZ cord-261058-yu2qw02l 197 3 the the DT cord-261058-yu2qw02l 197 4 most most RBS cord-261058-yu2qw02l 197 5 common common JJ cord-261058-yu2qw02l 197 6 cause cause NN cord-261058-yu2qw02l 197 7 of of IN cord-261058-yu2qw02l 197 8 heart heart NN cord-261058-yu2qw02l 197 9 disease disease NN cord-261058-yu2qw02l 197 10 acquired acquire VBN cord-261058-yu2qw02l 197 11 in in IN cord-261058-yu2qw02l 197 12 childhood childhood NN cord-261058-yu2qw02l 197 13 and and CC cord-261058-yu2qw02l 197 14 an an DT cord-261058-yu2qw02l 197 15 important important JJ cord-261058-yu2qw02l 197 16 paradigm paradigm NN cord-261058-yu2qw02l 197 17 for for IN cord-261058-yu2qw02l 197 18 understanding understand VBG cord-261058-yu2qw02l 197 19 the the DT cord-261058-yu2qw02l 197 20 determinants determinant NNS cord-261058-yu2qw02l 197 21 of of IN cord-261058-yu2qw02l 197 22 adult adult NN cord-261058-yu2qw02l 197 23 cardiovascular cardiovascular JJ cord-261058-yu2qw02l 197 24 pathology pathology NN cord-261058-yu2qw02l 197 25 . . . cord-261058-yu2qw02l 198 1 The the DT cord-261058-yu2qw02l 198 2 epidemiology epidemiology NN cord-261058-yu2qw02l 198 3 is be VBZ cord-261058-yu2qw02l 198 4 well well RB cord-261058-yu2qw02l 198 5 characterised characterised JJ cord-261058-yu2qw02l 198 6 and and CC cord-261058-yu2qw02l 198 7 clearly clearly RB cord-261058-yu2qw02l 198 8 supports support VBZ cord-261058-yu2qw02l 198 9 the the DT cord-261058-yu2qw02l 198 10 view view NN cord-261058-yu2qw02l 198 11 that that IN cord-261058-yu2qw02l 198 12 the the DT cord-261058-yu2qw02l 198 13 disease disease NN cord-261058-yu2qw02l 198 14 results result VBZ cord-261058-yu2qw02l 198 15 from from IN cord-261058-yu2qw02l 198 16 an an DT cord-261058-yu2qw02l 198 17 inappropriate inappropriate JJ cord-261058-yu2qw02l 198 18 immunological immunological JJ cord-261058-yu2qw02l 198 19 response response NN cord-261058-yu2qw02l 198 20 to to IN cord-261058-yu2qw02l 198 21 one one CD cord-261058-yu2qw02l 198 22 or or CC cord-261058-yu2qw02l 198 23 more more RBR cord-261058-yu2qw02l 198 24 infectious infectious JJ cord-261058-yu2qw02l 198 25 triggers trigger NNS cord-261058-yu2qw02l 198 26 in in IN cord-261058-yu2qw02l 198 27 genetically genetically RB cord-261058-yu2qw02l 198 28 - - HYPH cord-261058-yu2qw02l 198 29 susceptible susceptible JJ cord-261058-yu2qw02l 198 30 individuals individual NNS cord-261058-yu2qw02l 198 31 . . . cord-261058-yu2qw02l 199 1 The the DT cord-261058-yu2qw02l 199 2 search search NN cord-261058-yu2qw02l 199 3 for for IN cord-261058-yu2qw02l 199 4 the the DT cord-261058-yu2qw02l 199 5 microbial microbial JJ cord-261058-yu2qw02l 199 6 etiology etiology NN cord-261058-yu2qw02l 199 7 has have VBZ cord-261058-yu2qw02l 199 8 been be VBN cord-261058-yu2qw02l 199 9 disappointing disappointing JJ cord-261058-yu2qw02l 199 10 and and CC cord-261058-yu2qw02l 199 11 unsuccessful unsuccessful JJ cord-261058-yu2qw02l 199 12 and and CC cord-261058-yu2qw02l 199 13 all all DT cord-261058-yu2qw02l 199 14 that that WDT cord-261058-yu2qw02l 199 15 remains remain VBZ cord-261058-yu2qw02l 199 16 of of IN cord-261058-yu2qw02l 199 17 over over IN cord-261058-yu2qw02l 199 18 three three CD cord-261058-yu2qw02l 199 19 decades decade NNS cord-261058-yu2qw02l 199 20 of of IN cord-261058-yu2qw02l 199 21 such such JJ cord-261058-yu2qw02l 199 22 studies study NNS cord-261058-yu2qw02l 199 23 is be VBZ cord-261058-yu2qw02l 199 24 a a DT cord-261058-yu2qw02l 199 25 ' ' `` cord-261058-yu2qw02l 199 26 long long JJ cord-261058-yu2qw02l 199 27 list list NN cord-261058-yu2qw02l 199 28 of of IN cord-261058-yu2qw02l 199 29 discarded discard VBN cord-261058-yu2qw02l 199 30 pathogens pathogen NNS cord-261058-yu2qw02l 199 31 ' ' '' cord-261058-yu2qw02l 199 32 . . . cord-261058-yu2qw02l 200 1 3 3 LS cord-261058-yu2qw02l 201 1 Understanding understand VBG cord-261058-yu2qw02l 201 2 the the DT cord-261058-yu2qw02l 201 3 genetic genetic JJ cord-261058-yu2qw02l 201 4 determinants determinant NNS cord-261058-yu2qw02l 201 5 of of IN cord-261058-yu2qw02l 201 6 susceptibility susceptibility NN cord-261058-yu2qw02l 201 7 to to IN cord-261058-yu2qw02l 201 8 KD KD NNP cord-261058-yu2qw02l 201 9 and and CC cord-261058-yu2qw02l 201 10 those those DT cord-261058-yu2qw02l 201 11 involved involve VBN cord-261058-yu2qw02l 201 12 in in IN cord-261058-yu2qw02l 201 13 mediating mediate VBG cord-261058-yu2qw02l 201 14 coronary coronary JJ cord-261058-yu2qw02l 201 15 artery artery NN cord-261058-yu2qw02l 201 16 damage damage NN cord-261058-yu2qw02l 201 17 may may MD cord-261058-yu2qw02l 201 18 be be VB cord-261058-yu2qw02l 201 19 a a DT cord-261058-yu2qw02l 201 20 more more RBR cord-261058-yu2qw02l 201 21 profitable profitable JJ cord-261058-yu2qw02l 201 22 approach approach NN cord-261058-yu2qw02l 201 23 . . . cord-261058-yu2qw02l 202 1 The the DT cord-261058-yu2qw02l 202 2 methodological methodological JJ cord-261058-yu2qw02l 202 3 issues issue NNS cord-261058-yu2qw02l 202 4 that that WDT cord-261058-yu2qw02l 202 5 have have VBP cord-261058-yu2qw02l 202 6 undermined undermine VBN cord-261058-yu2qw02l 202 7 genetic genetic JJ cord-261058-yu2qw02l 202 8 analyses analysis NNS cord-261058-yu2qw02l 202 9 can can MD cord-261058-yu2qw02l 202 10 be be VB cord-261058-yu2qw02l 202 11 largely largely RB cord-261058-yu2qw02l 202 12 overcome overcome VBN cord-261058-yu2qw02l 202 13 by by IN cord-261058-yu2qw02l 202 14 international international JJ cord-261058-yu2qw02l 202 15 collaborative collaborative JJ cord-261058-yu2qw02l 202 16 studies study NNS cord-261058-yu2qw02l 202 17 that that WDT cord-261058-yu2qw02l 202 18 employ employ VBP cord-261058-yu2qw02l 202 19 standardised standardised JJ cord-261058-yu2qw02l 202 20 phenotypic phenotypic JJ cord-261058-yu2qw02l 202 21 definitions definition NNS cord-261058-yu2qw02l 202 22 and and CC cord-261058-yu2qw02l 202 23 large large JJ cord-261058-yu2qw02l 202 24 sample sample NN cord-261058-yu2qw02l 202 25 sizes size NNS cord-261058-yu2qw02l 202 26 derived derive VBN cord-261058-yu2qw02l 202 27 from from IN cord-261058-yu2qw02l 202 28 different different JJ cord-261058-yu2qw02l 202 29 ethnic ethnic JJ cord-261058-yu2qw02l 202 30 groups group NNS cord-261058-yu2qw02l 202 31 . . . cord-261058-yu2qw02l 203 1 The the DT cord-261058-yu2qw02l 203 2 use use NN cord-261058-yu2qw02l 203 3 of of IN cord-261058-yu2qw02l 203 4 familybased familybased JJ cord-261058-yu2qw02l 203 5 genetic genetic JJ cord-261058-yu2qw02l 203 6 association association NNP cord-261058-yu2qw02l 203 7 analyses analyse VBZ cord-261058-yu2qw02l 203 8 95 95 CD cord-261058-yu2qw02l 203 9 circumvents circumvent VBZ cord-261058-yu2qw02l 203 10 the the DT cord-261058-yu2qw02l 203 11 problems problem NNS cord-261058-yu2qw02l 203 12 of of IN cord-261058-yu2qw02l 203 13 population population NN cord-261058-yu2qw02l 203 14 stratification stratification NN cord-261058-yu2qw02l 203 15 and and CC cord-261058-yu2qw02l 203 16 the the DT cord-261058-yu2qw02l 203 17 use use NN cord-261058-yu2qw02l 203 18 of of IN cord-261058-yu2qw02l 203 19 trans trans JJ cord-261058-yu2qw02l 203 20 - - JJ cord-261058-yu2qw02l 203 21 racial racial JJ cord-261058-yu2qw02l 203 22 mapping mapping NN cord-261058-yu2qw02l 203 23 ( ( -LRB- cord-261058-yu2qw02l 203 24 i.e. i.e. FW cord-261058-yu2qw02l 203 25 investigating investigate VBG cord-261058-yu2qw02l 203 26 genetic genetic JJ cord-261058-yu2qw02l 203 27 determinants determinant NNS cord-261058-yu2qw02l 203 28 in in IN cord-261058-yu2qw02l 203 29 different different JJ cord-261058-yu2qw02l 203 30 ethnic ethnic JJ cord-261058-yu2qw02l 203 31 groups group NNS cord-261058-yu2qw02l 203 32 ) ) -RRB- cord-261058-yu2qw02l 204 1 96 96 CD cord-261058-yu2qw02l 204 2 may may MD cord-261058-yu2qw02l 204 3 prove prove VB cord-261058-yu2qw02l 204 4 important important JJ cord-261058-yu2qw02l 204 5 to to IN cord-261058-yu2qw02l 204 6 defining define VBG cord-261058-yu2qw02l 204 7 the the DT cord-261058-yu2qw02l 204 8 critical critical JJ cord-261058-yu2qw02l 204 9 genetic genetic JJ cord-261058-yu2qw02l 204 10 determinants determinant NNS cord-261058-yu2qw02l 204 11 , , , cord-261058-yu2qw02l 204 12 particularly particularly RB cord-261058-yu2qw02l 204 13 in in IN cord-261058-yu2qw02l 204 14 regions region NNS cord-261058-yu2qw02l 204 15 of of IN cord-261058-yu2qw02l 204 16 high high JJ cord-261058-yu2qw02l 204 17 linkage linkage NN cord-261058-yu2qw02l 204 18 disequilibrium disequilibrium NN cord-261058-yu2qw02l 204 19 . . . cord-261058-yu2qw02l 205 1 Newer new JJR cord-261058-yu2qw02l 205 2 molecular molecular JJ cord-261058-yu2qw02l 205 3 techniques technique NNS cord-261058-yu2qw02l 205 4 , , , cord-261058-yu2qw02l 205 5 particularly particularly RB cord-261058-yu2qw02l 205 6 gene gene NN cord-261058-yu2qw02l 205 7 expression expression NN cord-261058-yu2qw02l 205 8 profiling profiling NN cord-261058-yu2qw02l 205 9 and and CC cord-261058-yu2qw02l 205 10 proteomics proteomic NNS cord-261058-yu2qw02l 205 11 may may MD cord-261058-yu2qw02l 205 12 identify identify VB cord-261058-yu2qw02l 205 13 novel novel JJ cord-261058-yu2qw02l 205 14 molecular molecular NN cord-261058-yu2qw02l 205 15 ' ' `` cord-261058-yu2qw02l 205 16 fingerprints fingerprint NNS cord-261058-yu2qw02l 205 17 ' ' '' cord-261058-yu2qw02l 205 18 that that WDT cord-261058-yu2qw02l 205 19 differentiate differentiate VBP cord-261058-yu2qw02l 205 20 KD KD NNP cord-261058-yu2qw02l 205 21 from from IN cord-261058-yu2qw02l 205 22 other other JJ cord-261058-yu2qw02l 205 23 febrile febrile JJ cord-261058-yu2qw02l 205 24 and and CC cord-261058-yu2qw02l 205 25 inflammatory inflammatory JJ cord-261058-yu2qw02l 205 26 illnesses illness NNS cord-261058-yu2qw02l 205 27 . . . cord-261058-yu2qw02l 206 1 3 3 LS cord-261058-yu2qw02l 207 1 The the DT cord-261058-yu2qw02l 207 2 mystery mystery NN cord-261058-yu2qw02l 207 3 of of IN cord-261058-yu2qw02l 207 4 KD KD NNP cord-261058-yu2qw02l 207 5 may may MD cord-261058-yu2qw02l 207 6 ultimately ultimately RB cord-261058-yu2qw02l 207 7 be be VB cord-261058-yu2qw02l 207 8 solved solve VBN cord-261058-yu2qw02l 207 9 by by IN cord-261058-yu2qw02l 207 10 looking look VBG cord-261058-yu2qw02l 207 11 within within IN cord-261058-yu2qw02l 207 12 the the DT cord-261058-yu2qw02l 207 13 host host NN cord-261058-yu2qw02l 207 14 . . . cord-261058-yu2qw02l 208 1 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 208 2 disease disease NN cord-261058-yu2qw02l 208 3 : : : cord-261058-yu2qw02l 208 4 a a DT cord-261058-yu2qw02l 208 5 brief brief JJ cord-261058-yu2qw02l 208 6 history history NN cord-261058-yu2qw02l 208 7 Acute acute NN cord-261058-yu2qw02l 208 8 febrile febrile JJ cord-261058-yu2qw02l 208 9 mucocutaneous mucocutaneous JJ cord-261058-yu2qw02l 208 10 syndrome syndrome NN cord-261058-yu2qw02l 208 11 with with IN cord-261058-yu2qw02l 208 12 lymphoid lymphoid JJ cord-261058-yu2qw02l 208 13 involvement involvement NN cord-261058-yu2qw02l 208 14 with with IN cord-261058-yu2qw02l 208 15 specific specific JJ cord-261058-yu2qw02l 208 16 desquamation desquamation NN cord-261058-yu2qw02l 208 17 of of IN cord-261058-yu2qw02l 208 18 the the DT cord-261058-yu2qw02l 208 19 fingers finger NNS cord-261058-yu2qw02l 208 20 and and CC cord-261058-yu2qw02l 208 21 toes toe NNS cord-261058-yu2qw02l 208 22 in in IN cord-261058-yu2qw02l 208 23 children child NNS cord-261058-yu2qw02l 208 24 ( ( -LRB- cord-261058-yu2qw02l 208 25 Japanese japanese JJ cord-261058-yu2qw02l 208 26 ) ) -RRB- cord-261058-yu2qw02l 208 27 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 208 28 syndrome syndrome NN cord-261058-yu2qw02l 208 29 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 208 30 disease disease NN cord-261058-yu2qw02l 208 31 characterized characterize VBN cord-261058-yu2qw02l 208 32 by by IN cord-261058-yu2qw02l 208 33 erythema erythema NN cord-261058-yu2qw02l 208 34 and and CC cord-261058-yu2qw02l 208 35 induration induration NN cord-261058-yu2qw02l 208 36 at at IN cord-261058-yu2qw02l 208 37 the the DT cord-261058-yu2qw02l 208 38 Bacillus Bacillus NNP cord-261058-yu2qw02l 208 39 Calmette Calmette NNP cord-261058-yu2qw02l 208 40 - - HYPH cord-261058-yu2qw02l 208 41 Guerin Guerin NNP cord-261058-yu2qw02l 208 42 and and CC cord-261058-yu2qw02l 208 43 purified purify VBN cord-261058-yu2qw02l 208 44 protein protein NN cord-261058-yu2qw02l 208 45 derivative derivative JJ cord-261058-yu2qw02l 208 46 inoculation inoculation NN cord-261058-yu2qw02l 208 47 sites site VBZ cord-261058-yu2qw02l 208 48 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 208 49 disease disease NN cord-261058-yu2qw02l 208 50 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 208 51 disease disease NN cord-261058-yu2qw02l 208 52 : : : cord-261058-yu2qw02l 208 53 an an DT cord-261058-yu2qw02l 208 54 evidence evidence NN cord-261058-yu2qw02l 208 55 based base VBN cord-261058-yu2qw02l 208 56 approach approach NN cord-261058-yu2qw02l 208 57 to to IN cord-261058-yu2qw02l 208 58 diagnosis diagnosis NN cord-261058-yu2qw02l 208 59 , , , cord-261058-yu2qw02l 208 60 treatment treatment NN cord-261058-yu2qw02l 208 61 , , , cord-261058-yu2qw02l 208 62 and and CC cord-261058-yu2qw02l 208 63 proposals proposal NNS cord-261058-yu2qw02l 208 64 for for IN cord-261058-yu2qw02l 208 65 future future JJ cord-261058-yu2qw02l 208 66 research research NN cord-261058-yu2qw02l 208 67 Effects effect NNS cord-261058-yu2qw02l 208 68 of of IN cord-261058-yu2qw02l 208 69 gamma gamma NN cord-261058-yu2qw02l 208 70 - - HYPH cord-261058-yu2qw02l 208 71 globulin globulin NN cord-261058-yu2qw02l 208 72 on on IN cord-261058-yu2qw02l 208 73 the the DT cord-261058-yu2qw02l 208 74 cardiac cardiac JJ cord-261058-yu2qw02l 208 75 sequelae sequela NNS cord-261058-yu2qw02l 208 76 of of IN cord-261058-yu2qw02l 208 77 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 208 78 disease disease NN cord-261058-yu2qw02l 208 79 Incomplete Incomplete NNP cord-261058-yu2qw02l 208 80 ( ( -LRB- cord-261058-yu2qw02l 208 81 atypical atypical JJ cord-261058-yu2qw02l 208 82 ) ) -RRB- cord-261058-yu2qw02l 208 83 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 208 84 disease disease NN cord-261058-yu2qw02l 208 85 Fate Fate NNP cord-261058-yu2qw02l 208 86 of of IN cord-261058-yu2qw02l 208 87 coronary coronary JJ cord-261058-yu2qw02l 208 88 aneurysms aneurysm NNS cord-261058-yu2qw02l 208 89 in in IN cord-261058-yu2qw02l 208 90 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 208 91 disease disease NN cord-261058-yu2qw02l 208 92 : : : cord-261058-yu2qw02l 208 93 serial serial JJ cord-261058-yu2qw02l 208 94 coronary coronary NN cord-261058-yu2qw02l 208 95 angiography angiography NN cord-261058-yu2qw02l 208 96 and and CC cord-261058-yu2qw02l 208 97 long long JJ cord-261058-yu2qw02l 208 98 - - HYPH cord-261058-yu2qw02l 208 99 term term NN cord-261058-yu2qw02l 208 100 followup followup JJ cord-261058-yu2qw02l 208 101 study study NN cord-261058-yu2qw02l 208 102 Cardiovascular cardiovascular JJ cord-261058-yu2qw02l 208 103 involvement involvement NN cord-261058-yu2qw02l 208 104 in in IN cord-261058-yu2qw02l 208 105 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 208 106 disease disease NN cord-261058-yu2qw02l 208 107 : : : cord-261058-yu2qw02l 208 108 evaluation evaluation NN cord-261058-yu2qw02l 208 109 and and CC cord-261058-yu2qw02l 208 110 natural natural JJ cord-261058-yu2qw02l 208 111 history history NN cord-261058-yu2qw02l 208 112 Mortality mortality NN cord-261058-yu2qw02l 208 113 among among IN cord-261058-yu2qw02l 208 114 patients patient NNS cord-261058-yu2qw02l 208 115 with with IN cord-261058-yu2qw02l 208 116 a a DT cord-261058-yu2qw02l 208 117 history history NN cord-261058-yu2qw02l 208 118 of of IN cord-261058-yu2qw02l 208 119 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 208 120 disease disease NN cord-261058-yu2qw02l 208 121 : : : cord-261058-yu2qw02l 208 122 the the DT cord-261058-yu2qw02l 208 123 third third JJ cord-261058-yu2qw02l 208 124 look look NN cord-261058-yu2qw02l 208 125 . . . cord-261058-yu2qw02l 209 1 The the DT cord-261058-yu2qw02l 209 2 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 209 3 Disease Disease NNP cord-261058-yu2qw02l 209 4 Follow Follow NNP cord-261058-yu2qw02l 209 5 - - HYPH cord-261058-yu2qw02l 209 6 up up RP cord-261058-yu2qw02l 209 7 Group Group NNP cord-261058-yu2qw02l 209 8 Clinical clinical JJ cord-261058-yu2qw02l 209 9 spectrum spectrum NN cord-261058-yu2qw02l 209 10 of of IN cord-261058-yu2qw02l 209 11 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 209 12 disease disease NN cord-261058-yu2qw02l 209 13 in in IN cord-261058-yu2qw02l 209 14 infants infant NNS cord-261058-yu2qw02l 209 15 younger young JJR cord-261058-yu2qw02l 209 16 than than IN cord-261058-yu2qw02l 209 17 6 6 CD cord-261058-yu2qw02l 209 18 months month NNS cord-261058-yu2qw02l 209 19 of of IN cord-261058-yu2qw02l 209 20 age age NN cord-261058-yu2qw02l 209 21 Long long JJ cord-261058-yu2qw02l 209 22 - - HYPH cord-261058-yu2qw02l 209 23 term term NN cord-261058-yu2qw02l 209 24 consequences consequence NNS cord-261058-yu2qw02l 209 25 of of IN cord-261058-yu2qw02l 209 26 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 209 27 disease disease NN cord-261058-yu2qw02l 209 28 . . . cord-261058-yu2qw02l 210 1 A a DT cord-261058-yu2qw02l 210 2 10-to 10-to CD cord-261058-yu2qw02l 210 3 21-year 21-year JJ cord-261058-yu2qw02l 210 4 follow follow NN cord-261058-yu2qw02l 210 5 - - HYPH cord-261058-yu2qw02l 210 6 up up NN cord-261058-yu2qw02l 210 7 study study NN cord-261058-yu2qw02l 210 8 of of IN cord-261058-yu2qw02l 210 9 594 594 CD cord-261058-yu2qw02l 210 10 patients patient NNS cord-261058-yu2qw02l 210 11 With with IN cord-261058-yu2qw02l 210 12 special special JJ cord-261058-yu2qw02l 210 13 reference reference NN cord-261058-yu2qw02l 210 14 to to IN cord-261058-yu2qw02l 210 15 the the DT cord-261058-yu2qw02l 210 16 heart heart NN cord-261058-yu2qw02l 210 17 and and CC cord-261058-yu2qw02l 210 18 coronary coronary JJ cord-261058-yu2qw02l 210 19 arterial arterial JJ cord-261058-yu2qw02l 210 20 lesions lesion NNS cord-261058-yu2qw02l 211 1 Pathological pathological JJ cord-261058-yu2qw02l 211 2 study study NN cord-261058-yu2qw02l 211 3 of of IN cord-261058-yu2qw02l 211 4 postcoronary postcoronary JJ cord-261058-yu2qw02l 211 5 arteritis arteritis NN cord-261058-yu2qw02l 211 6 in in IN cord-261058-yu2qw02l 211 7 adolescents adolescent NNS cord-261058-yu2qw02l 211 8 and and CC cord-261058-yu2qw02l 211 9 young young JJ cord-261058-yu2qw02l 211 10 adults adult NNS cord-261058-yu2qw02l 211 11 : : : cord-261058-yu2qw02l 211 12 with with IN cord-261058-yu2qw02l 211 13 reference reference NN cord-261058-yu2qw02l 211 14 to to IN cord-261058-yu2qw02l 211 15 the the DT cord-261058-yu2qw02l 211 16 relationship relationship NN cord-261058-yu2qw02l 211 17 between between IN cord-261058-yu2qw02l 211 18 sequelae sequela NNS cord-261058-yu2qw02l 211 19 of of IN cord-261058-yu2qw02l 211 20 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 211 21 disease disease NN cord-261058-yu2qw02l 211 22 and and CC cord-261058-yu2qw02l 211 23 atherosclerosis atherosclerosis NN cord-261058-yu2qw02l 211 24 Endothelial endothelial JJ cord-261058-yu2qw02l 211 25 dysfunction dysfunction NN cord-261058-yu2qw02l 211 26 late late RB cord-261058-yu2qw02l 211 27 after after IN cord-261058-yu2qw02l 211 28 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 211 29 disease disease NN cord-261058-yu2qw02l 211 30 Long long JJ cord-261058-yu2qw02l 211 31 term term NN cord-261058-yu2qw02l 211 32 consequences consequence NNS cord-261058-yu2qw02l 211 33 of of IN cord-261058-yu2qw02l 211 34 regressed regress VBN cord-261058-yu2qw02l 211 35 coronary coronary JJ cord-261058-yu2qw02l 211 36 aneurysms aneurysm NNS cord-261058-yu2qw02l 211 37 after after IN cord-261058-yu2qw02l 211 38 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 211 39 disease disease NN cord-261058-yu2qw02l 211 40 : : : cord-261058-yu2qw02l 211 41 vascular vascular JJ cord-261058-yu2qw02l 211 42 wall wall NN cord-261058-yu2qw02l 211 43 morphology morphology NN cord-261058-yu2qw02l 211 44 and and CC cord-261058-yu2qw02l 211 45 function function VB cord-261058-yu2qw02l 211 46 Noninvasive noninvasive JJ cord-261058-yu2qw02l 211 47 assessment assessment NN cord-261058-yu2qw02l 211 48 of of IN cord-261058-yu2qw02l 211 49 the the DT cord-261058-yu2qw02l 211 50 early early JJ cord-261058-yu2qw02l 211 51 progression progression NN cord-261058-yu2qw02l 211 52 of of IN cord-261058-yu2qw02l 211 53 atherosclerosis atherosclerosis NN cord-261058-yu2qw02l 211 54 in in IN cord-261058-yu2qw02l 211 55 adolescents adolescent NNS cord-261058-yu2qw02l 211 56 with with IN cord-261058-yu2qw02l 211 57 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 211 58 disease disease NN cord-261058-yu2qw02l 211 59 and and CC cord-261058-yu2qw02l 211 60 coronary coronary JJ cord-261058-yu2qw02l 211 61 artery artery NN cord-261058-yu2qw02l 211 62 lesions lesion NNS cord-261058-yu2qw02l 212 1 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 212 2 disease disease NN cord-261058-yu2qw02l 212 3 - - : cord-261058-yu2qw02l 212 4 from from IN cord-261058-yu2qw02l 212 5 a a DT cord-261058-yu2qw02l 212 6 mystery mystery NN cord-261058-yu2qw02l 212 7 to to IN cord-261058-yu2qw02l 212 8 a a DT cord-261058-yu2qw02l 212 9 paradigm paradigm NN cord-261058-yu2qw02l 212 10 Impact impact NN cord-261058-yu2qw02l 212 11 of of IN cord-261058-yu2qw02l 212 12 infectious infectious JJ cord-261058-yu2qw02l 212 13 burden burden NN cord-261058-yu2qw02l 212 14 on on IN cord-261058-yu2qw02l 212 15 extent extent NN cord-261058-yu2qw02l 212 16 and and CC cord-261058-yu2qw02l 212 17 long long JJ cord-261058-yu2qw02l 212 18 - - HYPH cord-261058-yu2qw02l 212 19 term term NN cord-261058-yu2qw02l 212 20 prognosis prognosis NN cord-261058-yu2qw02l 212 21 of of IN cord-261058-yu2qw02l 212 22 atherosclerosis atherosclerosis NN cord-261058-yu2qw02l 212 23 Acute acute JJ cord-261058-yu2qw02l 212 24 infections infection NNS cord-261058-yu2qw02l 212 25 in in IN cord-261058-yu2qw02l 212 26 children child NNS cord-261058-yu2qw02l 212 27 are be VBP cord-261058-yu2qw02l 212 28 accompanied accompany VBN cord-261058-yu2qw02l 212 29 by by IN cord-261058-yu2qw02l 212 30 oxidative oxidative JJ cord-261058-yu2qw02l 212 31 modification modification NN cord-261058-yu2qw02l 212 32 of of IN cord-261058-yu2qw02l 212 33 LDL ldl NN cord-261058-yu2qw02l 212 34 and and CC cord-261058-yu2qw02l 212 35 decrease decrease NN cord-261058-yu2qw02l 212 36 of of IN cord-261058-yu2qw02l 212 37 HDL HDL NNP cord-261058-yu2qw02l 212 38 cholesterol cholesterol NN cord-261058-yu2qw02l 212 39 , , , cord-261058-yu2qw02l 212 40 and and CC cord-261058-yu2qw02l 212 41 are be VBP cord-261058-yu2qw02l 212 42 followed follow VBN cord-261058-yu2qw02l 212 43 by by IN cord-261058-yu2qw02l 212 44 thickening thickening NN cord-261058-yu2qw02l 212 45 of of IN cord-261058-yu2qw02l 212 46 carotid carotid JJ cord-261058-yu2qw02l 212 47 intima intima NN cord-261058-yu2qw02l 212 48 - - HYPH cord-261058-yu2qw02l 212 49 media medium NNS cord-261058-yu2qw02l 212 50 A a DT cord-261058-yu2qw02l 212 51 single single JJ cord-261058-yu2qw02l 212 52 intravenous intravenous JJ cord-261058-yu2qw02l 212 53 infusion infusion NN cord-261058-yu2qw02l 212 54 of of IN cord-261058-yu2qw02l 212 55 gamma gamma NN cord-261058-yu2qw02l 212 56 globulin globulin NN cord-261058-yu2qw02l 212 57 as as IN cord-261058-yu2qw02l 212 58 compared compare VBN cord-261058-yu2qw02l 212 59 with with IN cord-261058-yu2qw02l 212 60 four four CD cord-261058-yu2qw02l 212 61 infusions infusion NNS cord-261058-yu2qw02l 212 62 in in IN cord-261058-yu2qw02l 212 63 the the DT cord-261058-yu2qw02l 212 64 treatment treatment NN cord-261058-yu2qw02l 212 65 of of IN cord-261058-yu2qw02l 212 66 acute acute JJ cord-261058-yu2qw02l 212 67 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 212 68 syndrome syndrome NN cord-261058-yu2qw02l 213 1 The the DT cord-261058-yu2qw02l 213 2 treatment treatment NN cord-261058-yu2qw02l 213 3 of of IN cord-261058-yu2qw02l 213 4 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 213 5 syndrome syndrome NN cord-261058-yu2qw02l 213 6 with with IN cord-261058-yu2qw02l 213 7 intravenous intravenous JJ cord-261058-yu2qw02l 213 8 gamma gamma NN cord-261058-yu2qw02l 213 9 globulin globulin NN cord-261058-yu2qw02l 213 10 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 213 11 disease disease NN cord-261058-yu2qw02l 213 12 in in IN cord-261058-yu2qw02l 213 13 Australia Australia NNP cord-261058-yu2qw02l 213 14 , , , cord-261058-yu2qw02l 213 15 1993 1993 CD cord-261058-yu2qw02l 213 16 - - SYM cord-261058-yu2qw02l 213 17 95 95 CD cord-261058-yu2qw02l 213 18 Immunoglobulin immunoglobulin NN cord-261058-yu2qw02l 213 19 failure failure NN cord-261058-yu2qw02l 213 20 and and CC cord-261058-yu2qw02l 213 21 retreatment retreatment NN cord-261058-yu2qw02l 213 22 in in IN cord-261058-yu2qw02l 213 23 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 213 24 disease disease NN cord-261058-yu2qw02l 213 25 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 213 26 disease disease NN cord-261058-yu2qw02l 213 27 in in IN cord-261058-yu2qw02l 213 28 children child NNS cord-261058-yu2qw02l 213 29 Classical Classical NNP cord-261058-yu2qw02l 213 30 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 213 31 disease disease NN cord-261058-yu2qw02l 213 32 in in IN cord-261058-yu2qw02l 213 33 a a DT cord-261058-yu2qw02l 213 34 neonate neonate NN cord-261058-yu2qw02l 213 35 Adult adult NN cord-261058-yu2qw02l 213 36 onset onset NN cord-261058-yu2qw02l 213 37 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 213 38 disease disease NN cord-261058-yu2qw02l 213 39 diagnosed diagnose VBN cord-261058-yu2qw02l 213 40 by by IN cord-261058-yu2qw02l 213 41 the the DT cord-261058-yu2qw02l 213 42 echocardiographic echocardiographic JJ cord-261058-yu2qw02l 213 43 demonstration demonstration NN cord-261058-yu2qw02l 213 44 of of IN cord-261058-yu2qw02l 213 45 coronary coronary JJ cord-261058-yu2qw02l 213 46 aneurysms aneurysm NNS cord-261058-yu2qw02l 213 47 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 213 48 disease disease NN cord-261058-yu2qw02l 213 49 : : : cord-261058-yu2qw02l 213 50 a a DT cord-261058-yu2qw02l 213 51 maturational maturational JJ cord-261058-yu2qw02l 213 52 defect defect NN cord-261058-yu2qw02l 213 53 in in IN cord-261058-yu2qw02l 213 54 immune immune JJ cord-261058-yu2qw02l 213 55 responsiveness responsiveness NN cord-261058-yu2qw02l 214 1 The the DT cord-261058-yu2qw02l 214 2 male male JJ cord-261058-yu2qw02l 214 3 predominance predominance NN cord-261058-yu2qw02l 214 4 in in IN cord-261058-yu2qw02l 214 5 the the DT cord-261058-yu2qw02l 214 6 incidence incidence NN cord-261058-yu2qw02l 214 7 of of IN cord-261058-yu2qw02l 214 8 infectious infectious JJ cord-261058-yu2qw02l 214 9 diseases disease NNS cord-261058-yu2qw02l 214 10 in in IN cord-261058-yu2qw02l 214 11 children child NNS cord-261058-yu2qw02l 214 12 : : : cord-261058-yu2qw02l 214 13 a a DT cord-261058-yu2qw02l 214 14 postulated postulate VBN cord-261058-yu2qw02l 214 15 explanation explanation NN cord-261058-yu2qw02l 214 16 for for IN cord-261058-yu2qw02l 214 17 disparities disparity NNS cord-261058-yu2qw02l 214 18 in in IN cord-261058-yu2qw02l 214 19 the the DT cord-261058-yu2qw02l 214 20 literature literature NN cord-261058-yu2qw02l 214 21 Genetic genetic JJ cord-261058-yu2qw02l 214 22 susceptibility susceptibility NN cord-261058-yu2qw02l 214 23 to to IN cord-261058-yu2qw02l 214 24 infectious infectious JJ cord-261058-yu2qw02l 214 25 diseases disease NNS cord-261058-yu2qw02l 215 1 Host host NN cord-261058-yu2qw02l 215 2 response response NN cord-261058-yu2qw02l 215 3 to to IN cord-261058-yu2qw02l 215 4 cytomegalovirus cytomegalovirus JJ cord-261058-yu2qw02l 215 5 infection infection NN cord-261058-yu2qw02l 215 6 as as IN cord-261058-yu2qw02l 215 7 a a DT cord-261058-yu2qw02l 215 8 determinant determinant NN cord-261058-yu2qw02l 215 9 of of IN cord-261058-yu2qw02l 215 10 susceptibility susceptibility NN cord-261058-yu2qw02l 215 11 to to IN cord-261058-yu2qw02l 215 12 coronary coronary JJ cord-261058-yu2qw02l 215 13 artery artery NN cord-261058-yu2qw02l 215 14 disease disease NN cord-261058-yu2qw02l 215 15 : : : cord-261058-yu2qw02l 215 16 sex sex NN cord-261058-yu2qw02l 215 17 - - HYPH cord-261058-yu2qw02l 215 18 based base VBN cord-261058-yu2qw02l 215 19 differences difference NNS cord-261058-yu2qw02l 215 20 in in IN cord-261058-yu2qw02l 215 21 inflammation inflammation NN cord-261058-yu2qw02l 215 22 and and CC cord-261058-yu2qw02l 215 23 type type NN cord-261058-yu2qw02l 215 24 of of IN cord-261058-yu2qw02l 215 25 immune immune JJ cord-261058-yu2qw02l 215 26 response response NN cord-261058-yu2qw02l 216 1 Rising rise VBG cord-261058-yu2qw02l 216 2 incidence incidence NN cord-261058-yu2qw02l 216 3 of of IN cord-261058-yu2qw02l 216 4 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 216 5 disease disease NN cord-261058-yu2qw02l 216 6 in in IN cord-261058-yu2qw02l 216 7 England England NNP cord-261058-yu2qw02l 216 8 : : : cord-261058-yu2qw02l 216 9 analysis analysis NN cord-261058-yu2qw02l 216 10 of of IN cord-261058-yu2qw02l 216 11 hospital hospital NN cord-261058-yu2qw02l 216 12 admission admission NN cord-261058-yu2qw02l 216 13 data datum NNS cord-261058-yu2qw02l 216 14 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 216 15 syndrome syndrome NN cord-261058-yu2qw02l 216 16 in in IN cord-261058-yu2qw02l 216 17 the the DT cord-261058-yu2qw02l 216 18 United United NNP cord-261058-yu2qw02l 216 19 States States NNP cord-261058-yu2qw02l 216 20 1976 1976 CD cord-261058-yu2qw02l 216 21 to to IN cord-261058-yu2qw02l 216 22 1980 1980 CD cord-261058-yu2qw02l 216 23 Hospitalizations hospitalization NNS cord-261058-yu2qw02l 216 24 for for IN cord-261058-yu2qw02l 216 25 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 216 26 disease disease NN cord-261058-yu2qw02l 216 27 among among IN cord-261058-yu2qw02l 216 28 children child NNS cord-261058-yu2qw02l 216 29 in in IN cord-261058-yu2qw02l 216 30 the the DT cord-261058-yu2qw02l 216 31 United United NNP cord-261058-yu2qw02l 216 32 States States NNP cord-261058-yu2qw02l 216 33 Epidemiologic Epidemiologic NNP cord-261058-yu2qw02l 216 34 picture picture NN cord-261058-yu2qw02l 216 35 of of IN cord-261058-yu2qw02l 216 36 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 216 37 disease disease NN cord-261058-yu2qw02l 216 38 in in IN cord-261058-yu2qw02l 216 39 Beijing Beijing NNP cord-261058-yu2qw02l 216 40 from from IN cord-261058-yu2qw02l 216 41 1995 1995 CD cord-261058-yu2qw02l 216 42 through through IN cord-261058-yu2qw02l 216 43 1999 1999 CD cord-261058-yu2qw02l 217 1 Epidemiologic epidemiologic JJ cord-261058-yu2qw02l 217 2 study study NN cord-261058-yu2qw02l 217 3 of of IN cord-261058-yu2qw02l 217 4 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 5 disease disease NN cord-261058-yu2qw02l 217 6 in in IN cord-261058-yu2qw02l 217 7 Korea Korea NNP cord-261058-yu2qw02l 217 8 , , , cord-261058-yu2qw02l 217 9 1997 1997 CD cord-261058-yu2qw02l 217 10 - - SYM cord-261058-yu2qw02l 217 11 1999 1999 CD cord-261058-yu2qw02l 217 12 : : : cord-261058-yu2qw02l 217 13 comparison comparison NN cord-261058-yu2qw02l 217 14 with with IN cord-261058-yu2qw02l 217 15 previous previous JJ cord-261058-yu2qw02l 217 16 studies study NNS cord-261058-yu2qw02l 217 17 during during IN cord-261058-yu2qw02l 217 18 1991 1991 CD cord-261058-yu2qw02l 217 19 - - SYM cord-261058-yu2qw02l 217 20 1996 1996 CD cord-261058-yu2qw02l 217 21 Results result NNS cord-261058-yu2qw02l 217 22 of of IN cord-261058-yu2qw02l 217 23 12 12 CD cord-261058-yu2qw02l 217 24 nationwide nationwide JJ cord-261058-yu2qw02l 217 25 epidemiological epidemiological JJ cord-261058-yu2qw02l 217 26 incidence incidence NN cord-261058-yu2qw02l 217 27 surveys survey NNS cord-261058-yu2qw02l 217 28 of of IN cord-261058-yu2qw02l 217 29 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 30 disease disease NN cord-261058-yu2qw02l 217 31 in in IN cord-261058-yu2qw02l 217 32 Japan Japan NNP cord-261058-yu2qw02l 217 33 Relationship Relationship NNP cord-261058-yu2qw02l 217 34 of of IN cord-261058-yu2qw02l 217 35 climate climate NN cord-261058-yu2qw02l 217 36 , , , cord-261058-yu2qw02l 217 37 ethnicity ethnicity NN cord-261058-yu2qw02l 217 38 and and CC cord-261058-yu2qw02l 217 39 socioeconomic socioeconomic JJ cord-261058-yu2qw02l 217 40 status status NN cord-261058-yu2qw02l 217 41 to to IN cord-261058-yu2qw02l 217 42 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 43 disease disease NN cord-261058-yu2qw02l 217 44 in in IN cord-261058-yu2qw02l 217 45 San San NNP cord-261058-yu2qw02l 217 46 Diego Diego NNP cord-261058-yu2qw02l 217 47 County County NNP cord-261058-yu2qw02l 217 48 Possible Possible NNP cord-261058-yu2qw02l 217 49 ' ' '' cord-261058-yu2qw02l 217 50 ' ' `` cord-261058-yu2qw02l 217 51 outbreak outbreak NN cord-261058-yu2qw02l 217 52 ' ' '' cord-261058-yu2qw02l 217 53 ' ' '' cord-261058-yu2qw02l 217 54 of of IN cord-261058-yu2qw02l 217 55 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 56 disease disease NN cord-261058-yu2qw02l 217 57 in in IN cord-261058-yu2qw02l 217 58 Victoria Victoria NNP cord-261058-yu2qw02l 217 59 Temporal Temporal NNP cord-261058-yu2qw02l 217 60 and and CC cord-261058-yu2qw02l 217 61 geographical geographical JJ cord-261058-yu2qw02l 217 62 clustering clustering NN cord-261058-yu2qw02l 217 63 of of IN cord-261058-yu2qw02l 217 64 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 65 disease disease NN cord-261058-yu2qw02l 217 66 in in IN cord-261058-yu2qw02l 217 67 Japan Japan NNP cord-261058-yu2qw02l 217 68 Nationwide Nationwide NNP cord-261058-yu2qw02l 217 69 epidemic epidemic NN cord-261058-yu2qw02l 217 70 of of IN cord-261058-yu2qw02l 217 71 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 72 disease disease NN cord-261058-yu2qw02l 217 73 in in IN cord-261058-yu2qw02l 217 74 Japan Japan NNP cord-261058-yu2qw02l 217 75 during during IN cord-261058-yu2qw02l 217 76 winter winter NN cord-261058-yu2qw02l 217 77 of of IN cord-261058-yu2qw02l 217 78 1985 1985 CD cord-261058-yu2qw02l 217 79 - - SYM cord-261058-yu2qw02l 217 80 86 86 CD cord-261058-yu2qw02l 217 81 Epidemiologic Epidemiologic NNP cord-261058-yu2qw02l 217 82 study study NN cord-261058-yu2qw02l 217 83 of of IN cord-261058-yu2qw02l 217 84 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 85 disease disease NN cord-261058-yu2qw02l 217 86 in in IN cord-261058-yu2qw02l 217 87 Korea Korea NNP cord-261058-yu2qw02l 217 88 An an DT cord-261058-yu2qw02l 217 89 epidemic epidemic NN cord-261058-yu2qw02l 217 90 of of IN cord-261058-yu2qw02l 217 91 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 92 syndrome syndrome NN cord-261058-yu2qw02l 217 93 in in IN cord-261058-yu2qw02l 217 94 Hawaii Hawaii NNP cord-261058-yu2qw02l 217 95 Cardiac Cardiac NNP cord-261058-yu2qw02l 217 96 sequelae sequela NNS cord-261058-yu2qw02l 217 97 of of IN cord-261058-yu2qw02l 217 98 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 99 disease disease NN cord-261058-yu2qw02l 217 100 among among IN cord-261058-yu2qw02l 217 101 recurrent recurrent JJ cord-261058-yu2qw02l 217 102 cases case NNS cord-261058-yu2qw02l 217 103 Recurrent recurrent JJ cord-261058-yu2qw02l 217 104 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 105 disease disease NN cord-261058-yu2qw02l 217 106 Search search VB cord-261058-yu2qw02l 217 107 for for IN cord-261058-yu2qw02l 217 108 highly highly RB cord-261058-yu2qw02l 217 109 conserved conserve VBN cord-261058-yu2qw02l 217 110 viral viral JJ cord-261058-yu2qw02l 217 111 and and CC cord-261058-yu2qw02l 217 112 bacterial bacterial JJ cord-261058-yu2qw02l 217 113 nucleic nucleic JJ cord-261058-yu2qw02l 217 114 acid acid NN cord-261058-yu2qw02l 217 115 sequences sequence NNS cord-261058-yu2qw02l 217 116 corresponding correspond VBG cord-261058-yu2qw02l 217 117 to to IN cord-261058-yu2qw02l 217 118 an an DT cord-261058-yu2qw02l 217 119 etiologic etiologic JJ cord-261058-yu2qw02l 217 120 agent agent NN cord-261058-yu2qw02l 217 121 of of IN cord-261058-yu2qw02l 217 122 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 123 disease disease NN cord-261058-yu2qw02l 217 124 Association Association NNP cord-261058-yu2qw02l 217 125 between between IN cord-261058-yu2qw02l 217 126 a a DT cord-261058-yu2qw02l 217 127 novel novel JJ cord-261058-yu2qw02l 217 128 human human JJ cord-261058-yu2qw02l 217 129 coronavirus coronavirus NN cord-261058-yu2qw02l 217 130 and and CC cord-261058-yu2qw02l 217 131 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 132 Disease Disease NNP cord-261058-yu2qw02l 217 133 Superantigens Superantigens NNP cord-261058-yu2qw02l 217 134 : : : cord-261058-yu2qw02l 217 135 microbial microbial JJ cord-261058-yu2qw02l 217 136 agents agent NNS cord-261058-yu2qw02l 217 137 that that WDT cord-261058-yu2qw02l 217 138 corrupt corrupt JJ cord-261058-yu2qw02l 217 139 immunity immunity NN cord-261058-yu2qw02l 217 140 Superantigens Superantigens NNP cord-261058-yu2qw02l 217 141 , , , cord-261058-yu2qw02l 217 142 conventional conventional JJ cord-261058-yu2qw02l 217 143 antigens antigen NNS cord-261058-yu2qw02l 217 144 and and CC cord-261058-yu2qw02l 217 145 the the DT cord-261058-yu2qw02l 217 146 etiology etiology NN cord-261058-yu2qw02l 217 147 of of IN cord-261058-yu2qw02l 217 148 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 149 syndrome syndrome NN cord-261058-yu2qw02l 217 150 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 217 151 disease disease NN cord-261058-yu2qw02l 217 152 and and CC cord-261058-yu2qw02l 217 153 toxic toxic JJ cord-261058-yu2qw02l 217 154 shock shock NN cord-261058-yu2qw02l 217 155 syndrome syndrome NN cord-261058-yu2qw02l 217 156 --at --at NN cord-261058-yu2qw02l 218 1 last last JJ cord-261058-yu2qw02l 218 2 the the DT cord-261058-yu2qw02l 218 3 etiology etiology NN cord-261058-yu2qw02l 218 4 is be VBZ cord-261058-yu2qw02l 218 5 clear clear JJ cord-261058-yu2qw02l 218 6 ? ? . cord-261058-yu2qw02l 219 1 Maternal maternal JJ cord-261058-yu2qw02l 219 2 antibody antibody NN cord-261058-yu2qw02l 219 3 against against IN cord-261058-yu2qw02l 219 4 toxic toxic JJ cord-261058-yu2qw02l 219 5 shock shock NN cord-261058-yu2qw02l 219 6 syndrome syndrome NN cord-261058-yu2qw02l 220 1 toxin-1 toxin-1 NNP cord-261058-yu2qw02l 220 2 may may MD cord-261058-yu2qw02l 220 3 protect protect VB cord-261058-yu2qw02l 220 4 infants infant NNS cord-261058-yu2qw02l 220 5 younger young JJR cord-261058-yu2qw02l 220 6 than than IN cord-261058-yu2qw02l 220 7 6 6 CD cord-261058-yu2qw02l 220 8 months month NNS cord-261058-yu2qw02l 220 9 of of IN cord-261058-yu2qw02l 220 10 age age NN cord-261058-yu2qw02l 220 11 from from IN cord-261058-yu2qw02l 220 12 developing develop VBG cord-261058-yu2qw02l 220 13 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 220 14 syndrome syndrome NN cord-261058-yu2qw02l 220 15 Prevalence prevalence NN cord-261058-yu2qw02l 220 16 of of IN cord-261058-yu2qw02l 220 17 superantigen superantigen NN cord-261058-yu2qw02l 220 18 - - HYPH cord-261058-yu2qw02l 220 19 secreting secrete VBG cord-261058-yu2qw02l 220 20 bacteria bacteria NNS cord-261058-yu2qw02l 220 21 in in IN cord-261058-yu2qw02l 220 22 patients patient NNS cord-261058-yu2qw02l 220 23 with with IN cord-261058-yu2qw02l 220 24 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 220 25 disease disease NN cord-261058-yu2qw02l 220 26 Chips chip NNS cord-261058-yu2qw02l 220 27 with with IN cord-261058-yu2qw02l 220 28 everything everything NN cord-261058-yu2qw02l 220 29 : : : cord-261058-yu2qw02l 220 30 DNA dna NN cord-261058-yu2qw02l 220 31 microarrays microarray NNS cord-261058-yu2qw02l 220 32 in in IN cord-261058-yu2qw02l 220 33 infectious infectious JJ cord-261058-yu2qw02l 220 34 diseases disease NNS cord-261058-yu2qw02l 220 35 Evidence evidence NN cord-261058-yu2qw02l 220 36 for for IN cord-261058-yu2qw02l 220 37 a a DT cord-261058-yu2qw02l 220 38 superantigen superantigen NN cord-261058-yu2qw02l 220 39 mediated mediate VBN cord-261058-yu2qw02l 220 40 process process NN cord-261058-yu2qw02l 220 41 in in IN cord-261058-yu2qw02l 220 42 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 220 43 disease disease NN cord-261058-yu2qw02l 220 44 Characterization characterization NN cord-261058-yu2qw02l 220 45 of of IN cord-261058-yu2qw02l 220 46 the the DT cord-261058-yu2qw02l 220 47 T t NN cord-261058-yu2qw02l 220 48 - - HYPH cord-261058-yu2qw02l 220 49 cell cell NN cord-261058-yu2qw02l 220 50 receptor receptor NN cord-261058-yu2qw02l 220 51 V v NN cord-261058-yu2qw02l 220 52 - - HYPH cord-261058-yu2qw02l 220 53 beta beta NN cord-261058-yu2qw02l 220 54 repertoire repertoire NN cord-261058-yu2qw02l 220 55 in in IN cord-261058-yu2qw02l 220 56 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 220 57 disease disease NN cord-261058-yu2qw02l 220 58 Detection detection NN cord-261058-yu2qw02l 220 59 of of IN cord-261058-yu2qw02l 220 60 antigen antigen NN cord-261058-yu2qw02l 220 61 in in IN cord-261058-yu2qw02l 220 62 bronchial bronchial JJ cord-261058-yu2qw02l 220 63 epithelium epithelium NN cord-261058-yu2qw02l 220 64 and and CC cord-261058-yu2qw02l 220 65 macrophages macrophage NNS cord-261058-yu2qw02l 220 66 in in IN cord-261058-yu2qw02l 220 67 acute acute JJ cord-261058-yu2qw02l 220 68 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 220 69 disease disease NN cord-261058-yu2qw02l 220 70 by by IN cord-261058-yu2qw02l 220 71 use use NN cord-261058-yu2qw02l 220 72 of of IN cord-261058-yu2qw02l 220 73 synthetic synthetic JJ cord-261058-yu2qw02l 220 74 antibody antibody NN cord-261058-yu2qw02l 220 75 Seasonal seasonal JJ cord-261058-yu2qw02l 220 76 trends trend NNS cord-261058-yu2qw02l 220 77 of of IN cord-261058-yu2qw02l 220 78 viral viral JJ cord-261058-yu2qw02l 220 79 respiratory respiratory JJ cord-261058-yu2qw02l 220 80 tract tract NN cord-261058-yu2qw02l 220 81 infections infection NNS cord-261058-yu2qw02l 220 82 in in IN cord-261058-yu2qw02l 220 83 the the DT cord-261058-yu2qw02l 220 84 tropics tropic NNS cord-261058-yu2qw02l 220 85 Epidemiology epidemiology NN cord-261058-yu2qw02l 220 86 of of IN cord-261058-yu2qw02l 220 87 respiratory respiratory JJ cord-261058-yu2qw02l 220 88 viral viral JJ cord-261058-yu2qw02l 220 89 infection infection NN cord-261058-yu2qw02l 220 90 among among IN cord-261058-yu2qw02l 220 91 paediatric paediatric JJ cord-261058-yu2qw02l 220 92 inpatients inpatient NNS cord-261058-yu2qw02l 220 93 over over IN cord-261058-yu2qw02l 220 94 a a DT cord-261058-yu2qw02l 220 95 six six CD cord-261058-yu2qw02l 220 96 - - HYPH cord-261058-yu2qw02l 220 97 year year NN cord-261058-yu2qw02l 220 98 period period NN cord-261058-yu2qw02l 220 99 in in IN cord-261058-yu2qw02l 220 100 north north NN cord-261058-yu2qw02l 220 101 - - HYPH cord-261058-yu2qw02l 220 102 east east NN cord-261058-yu2qw02l 220 103 England England NNP cord-261058-yu2qw02l 221 1 The the DT cord-261058-yu2qw02l 221 2 nasopharyngeal nasopharyngeal JJ cord-261058-yu2qw02l 221 3 bacterial bacterial JJ cord-261058-yu2qw02l 221 4 flora flora NNS cord-261058-yu2qw02l 221 5 in in IN cord-261058-yu2qw02l 221 6 infancy infancy NN cord-261058-yu2qw02l 221 7 : : : cord-261058-yu2qw02l 221 8 effects effect NNS cord-261058-yu2qw02l 221 9 of of IN cord-261058-yu2qw02l 221 10 age age NN cord-261058-yu2qw02l 221 11 , , , cord-261058-yu2qw02l 221 12 gender gender NN cord-261058-yu2qw02l 221 13 , , , cord-261058-yu2qw02l 221 14 season season NN cord-261058-yu2qw02l 221 15 , , , cord-261058-yu2qw02l 221 16 viral viral JJ cord-261058-yu2qw02l 221 17 upper upper JJ cord-261058-yu2qw02l 221 18 respiratory respiratory JJ cord-261058-yu2qw02l 221 19 tract tract NN cord-261058-yu2qw02l 221 20 infection infection NN cord-261058-yu2qw02l 221 21 and and CC cord-261058-yu2qw02l 221 22 sleeping sleeping NN cord-261058-yu2qw02l 221 23 position position NN cord-261058-yu2qw02l 221 24 Outbreak outbreak NN cord-261058-yu2qw02l 221 25 of of IN cord-261058-yu2qw02l 221 26 meningococcal meningococcal JJ cord-261058-yu2qw02l 221 27 disease disease NN cord-261058-yu2qw02l 221 28 after after IN cord-261058-yu2qw02l 221 29 an an DT cord-261058-yu2qw02l 221 30 influenza influenza NN cord-261058-yu2qw02l 221 31 B b NN cord-261058-yu2qw02l 221 32 epidemic epidemic NN cord-261058-yu2qw02l 221 33 at at IN cord-261058-yu2qw02l 221 34 a a DT cord-261058-yu2qw02l 221 35 Hellenic Hellenic NNP cord-261058-yu2qw02l 221 36 Air Air NNP cord-261058-yu2qw02l 221 37 Force Force NNP cord-261058-yu2qw02l 221 38 recruit recruit VB cord-261058-yu2qw02l 221 39 training training NN cord-261058-yu2qw02l 221 40 center center NN cord-261058-yu2qw02l 221 41 Influenza Influenza NNP cord-261058-yu2qw02l 221 42 A A NNP cord-261058-yu2qw02l 221 43 and and CC cord-261058-yu2qw02l 221 44 meningococcal meningococcal JJ cord-261058-yu2qw02l 221 45 disease disease NN cord-261058-yu2qw02l 221 46 Increased increase VBN cord-261058-yu2qw02l 221 47 expression expression NN cord-261058-yu2qw02l 221 48 of of IN cord-261058-yu2qw02l 221 49 human human JJ cord-261058-yu2qw02l 221 50 63-kD 63-kd CD cord-261058-yu2qw02l 221 51 heat heat NN cord-261058-yu2qw02l 221 52 shock shock NN cord-261058-yu2qw02l 221 53 protein protein NN cord-261058-yu2qw02l 221 54 gene gene NN cord-261058-yu2qw02l 221 55 in in IN cord-261058-yu2qw02l 221 56 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 221 57 disease disease NN cord-261058-yu2qw02l 221 58 determined determine VBN cord-261058-yu2qw02l 221 59 by by IN cord-261058-yu2qw02l 221 60 quantitative quantitative JJ cord-261058-yu2qw02l 221 61 reverse reverse JJ cord-261058-yu2qw02l 221 62 transcription transcription NN cord-261058-yu2qw02l 221 63 - - HYPH cord-261058-yu2qw02l 221 64 polymerase polymerase NN cord-261058-yu2qw02l 221 65 chain chain NN cord-261058-yu2qw02l 221 66 reaction reaction NN cord-261058-yu2qw02l 221 67 T T NNP cord-261058-yu2qw02l 221 68 cells cell NNS cord-261058-yu2qw02l 221 69 recognize recognize VBP cord-261058-yu2qw02l 221 70 an an DT cord-261058-yu2qw02l 221 71 immunodominant immunodominant JJ cord-261058-yu2qw02l 221 72 epitope epitope NN cord-261058-yu2qw02l 221 73 of of IN cord-261058-yu2qw02l 221 74 heat heat NN cord-261058-yu2qw02l 221 75 shock shock NN cord-261058-yu2qw02l 221 76 protein protein NN cord-261058-yu2qw02l 221 77 65 65 CD cord-261058-yu2qw02l 221 78 in in IN cord-261058-yu2qw02l 221 79 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 221 80 disease disease NN cord-261058-yu2qw02l 222 1 A a DT cord-261058-yu2qw02l 222 2 toxic toxic JJ cord-261058-yu2qw02l 222 3 shock shock NN cord-261058-yu2qw02l 222 4 syndrome syndrome NN cord-261058-yu2qw02l 222 5 toxin-1 toxin-1 NNP cord-261058-yu2qw02l 222 6 peptide peptide NN cord-261058-yu2qw02l 222 7 that that WDT cord-261058-yu2qw02l 222 8 shows show VBZ cord-261058-yu2qw02l 222 9 homology homology NN cord-261058-yu2qw02l 222 10 to to IN cord-261058-yu2qw02l 222 11 amino amino JJ cord-261058-yu2qw02l 222 12 acids acid NNS cord-261058-yu2qw02l 222 13 180 180 CD cord-261058-yu2qw02l 222 14 - - SYM cord-261058-yu2qw02l 222 15 193 193 CD cord-261058-yu2qw02l 222 16 of of IN cord-261058-yu2qw02l 222 17 mycobacterial mycobacterial NNP cord-261058-yu2qw02l 222 18 heat heat NNP cord-261058-yu2qw02l 222 19 shock shock NN cord-261058-yu2qw02l 222 20 protein protein NN cord-261058-yu2qw02l 222 21 65 65 CD cord-261058-yu2qw02l 222 22 is be VBZ cord-261058-yu2qw02l 222 23 presented present VBN cord-261058-yu2qw02l 222 24 as as IN cord-261058-yu2qw02l 222 25 conventional conventional JJ cord-261058-yu2qw02l 222 26 antigen antigen NN cord-261058-yu2qw02l 222 27 Human Human NNP cord-261058-yu2qw02l 222 28 heat heat NN cord-261058-yu2qw02l 222 29 shock shock NN cord-261058-yu2qw02l 222 30 protein protein NN cord-261058-yu2qw02l 222 31 60 60 CD cord-261058-yu2qw02l 222 32 induces induce VBZ cord-261058-yu2qw02l 222 33 maturation maturation NN cord-261058-yu2qw02l 222 34 of of IN cord-261058-yu2qw02l 222 35 dendritic dendritic JJ cord-261058-yu2qw02l 222 36 cells cell NNS cord-261058-yu2qw02l 222 37 versus versus IN cord-261058-yu2qw02l 222 38 a a DT cord-261058-yu2qw02l 222 39 Th1-promoting th1-promoting NN cord-261058-yu2qw02l 222 40 phenotype phenotype NN cord-261058-yu2qw02l 222 41 Summary summary NN cord-261058-yu2qw02l 222 42 and and CC cord-261058-yu2qw02l 222 43 abstracts abstract NNS cord-261058-yu2qw02l 222 44 of of IN cord-261058-yu2qw02l 222 45 the the DT cord-261058-yu2qw02l 222 46 Seventh Seventh NNP cord-261058-yu2qw02l 222 47 International International NNP cord-261058-yu2qw02l 222 48 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 222 49 Disease Disease NNP cord-261058-yu2qw02l 222 50 Symposium Symposium NNP cord-261058-yu2qw02l 222 51 Surveillance Surveillance NNP cord-261058-yu2qw02l 222 52 of of IN cord-261058-yu2qw02l 222 53 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 222 54 disease disease NN cord-261058-yu2qw02l 222 55 in in IN cord-261058-yu2qw02l 222 56 Taiwan Taiwan NNP cord-261058-yu2qw02l 222 57 and and CC cord-261058-yu2qw02l 222 58 review review NN cord-261058-yu2qw02l 222 59 of of IN cord-261058-yu2qw02l 222 60 the the DT cord-261058-yu2qw02l 222 61 literature literature NN cord-261058-yu2qw02l 222 62 Physical physical JJ cord-261058-yu2qw02l 222 63 and and CC cord-261058-yu2qw02l 222 64 psychosocial psychosocial JJ cord-261058-yu2qw02l 222 65 health health NN cord-261058-yu2qw02l 222 66 in in IN cord-261058-yu2qw02l 222 67 children child NNS cord-261058-yu2qw02l 222 68 who who WP cord-261058-yu2qw02l 222 69 have have VBP cord-261058-yu2qw02l 222 70 had have VBN cord-261058-yu2qw02l 222 71 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 222 72 disease disease NN cord-261058-yu2qw02l 222 73 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 222 74 disease disease NN cord-261058-yu2qw02l 222 75 in in IN cord-261058-yu2qw02l 222 76 families family NNS cord-261058-yu2qw02l 222 77 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 222 78 disease disease NN cord-261058-yu2qw02l 222 79 in in IN cord-261058-yu2qw02l 222 80 siblings sibling NNS cord-261058-yu2qw02l 223 1 The the DT cord-261058-yu2qw02l 223 2 value value NN cord-261058-yu2qw02l 223 3 of of IN cord-261058-yu2qw02l 223 4 isolated isolate VBN cord-261058-yu2qw02l 223 5 populations population NNS cord-261058-yu2qw02l 223 6 in in IN cord-261058-yu2qw02l 223 7 genetic genetic JJ cord-261058-yu2qw02l 223 8 studies study NNS cord-261058-yu2qw02l 223 9 of of IN cord-261058-yu2qw02l 223 10 allergic allergic JJ cord-261058-yu2qw02l 223 11 diseases disease NNS cord-261058-yu2qw02l 223 12 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 223 13 disease disease NN cord-261058-yu2qw02l 223 14 in in IN cord-261058-yu2qw02l 223 15 parents parent NNS cord-261058-yu2qw02l 223 16 and and CC cord-261058-yu2qw02l 223 17 children child NNS cord-261058-yu2qw02l 223 18 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 223 19 syndrome syndrome NN cord-261058-yu2qw02l 223 20 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 223 21 disease disease NN cord-261058-yu2qw02l 223 22 : : : cord-261058-yu2qw02l 223 23 review review NN cord-261058-yu2qw02l 223 24 of of IN cord-261058-yu2qw02l 223 25 risk risk NN cord-261058-yu2qw02l 223 26 factors factor NNS cord-261058-yu2qw02l 223 27 for for IN cord-261058-yu2qw02l 223 28 coronary coronary JJ cord-261058-yu2qw02l 223 29 aneurysms aneurysm NNS cord-261058-yu2qw02l 224 1 Coronary coronary JJ cord-261058-yu2qw02l 224 2 risks risk NNS cord-261058-yu2qw02l 224 3 after after IN cord-261058-yu2qw02l 224 4 high high JJ cord-261058-yu2qw02l 224 5 - - HYPH cord-261058-yu2qw02l 224 6 dose dose NN cord-261058-yu2qw02l 224 7 gamma gamma NN cord-261058-yu2qw02l 224 8 - - HYPH cord-261058-yu2qw02l 224 9 globulin globulin NN cord-261058-yu2qw02l 224 10 in in IN cord-261058-yu2qw02l 224 11 children child NNS cord-261058-yu2qw02l 224 12 with with IN cord-261058-yu2qw02l 224 13 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 224 14 disease disease NN cord-261058-yu2qw02l 224 15 Clinical clinical JJ cord-261058-yu2qw02l 224 16 relevance relevance NN cord-261058-yu2qw02l 224 17 of of IN cord-261058-yu2qw02l 224 18 the the DT cord-261058-yu2qw02l 224 19 risk risk NN cord-261058-yu2qw02l 224 20 factors factor NNS cord-261058-yu2qw02l 224 21 for for IN cord-261058-yu2qw02l 224 22 coronary coronary JJ cord-261058-yu2qw02l 224 23 artery artery NN cord-261058-yu2qw02l 224 24 inflammation inflammation NN cord-261058-yu2qw02l 224 25 in in IN cord-261058-yu2qw02l 224 26 kawasaki kawasaki NNP cord-261058-yu2qw02l 224 27 disease disease NNP cord-261058-yu2qw02l 224 28 Coronary Coronary NNP cord-261058-yu2qw02l 224 29 artery artery NN cord-261058-yu2qw02l 224 30 involvement involvement NN cord-261058-yu2qw02l 224 31 in in IN cord-261058-yu2qw02l 224 32 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 224 33 syndrome syndrome NN cord-261058-yu2qw02l 224 34 in in IN cord-261058-yu2qw02l 224 35 Manhattan Manhattan NNP cord-261058-yu2qw02l 224 36 Cytokines Cytokines NNPS cord-261058-yu2qw02l 224 37 predict predict VBP cord-261058-yu2qw02l 224 38 coronary coronary JJ cord-261058-yu2qw02l 224 39 aneurysm aneurysm NN cord-261058-yu2qw02l 224 40 formation formation NN cord-261058-yu2qw02l 224 41 in in IN cord-261058-yu2qw02l 224 42 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 224 43 disease disease NN cord-261058-yu2qw02l 224 44 patients patient NNS cord-261058-yu2qw02l 224 45 Raised raise VBD cord-261058-yu2qw02l 224 46 serum serum NN cord-261058-yu2qw02l 224 47 interleukin interleukin NN cord-261058-yu2qw02l 224 48 15 15 CD cord-261058-yu2qw02l 224 49 levels level NNS cord-261058-yu2qw02l 224 50 in in IN cord-261058-yu2qw02l 224 51 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 224 52 disease disease NN cord-261058-yu2qw02l 224 53 Urinary urinary JJ cord-261058-yu2qw02l 224 54 neopterin neopterin NN cord-261058-yu2qw02l 224 55 as as IN cord-261058-yu2qw02l 224 56 a a DT cord-261058-yu2qw02l 224 57 predictive predictive JJ cord-261058-yu2qw02l 224 58 marker marker NN cord-261058-yu2qw02l 224 59 of of IN cord-261058-yu2qw02l 224 60 coronary coronary JJ cord-261058-yu2qw02l 224 61 artery artery NN cord-261058-yu2qw02l 224 62 abnormalities abnormality NNS cord-261058-yu2qw02l 224 63 in in IN cord-261058-yu2qw02l 224 64 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 224 65 syndrome syndrome NN cord-261058-yu2qw02l 224 66 Genetic genetic JJ cord-261058-yu2qw02l 224 67 influence influence NN cord-261058-yu2qw02l 224 68 on on IN cord-261058-yu2qw02l 224 69 cytokine cytokine NN cord-261058-yu2qw02l 224 70 production production NN cord-261058-yu2qw02l 224 71 and and CC cord-261058-yu2qw02l 224 72 fatal fatal JJ cord-261058-yu2qw02l 224 73 meningococcal meningococcal JJ cord-261058-yu2qw02l 224 74 disease disease NN cord-261058-yu2qw02l 224 75 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 224 76 disease disease NN cord-261058-yu2qw02l 224 77 : : : cord-261058-yu2qw02l 224 78 the the DT cord-261058-yu2qw02l 224 79 mystery mystery NN cord-261058-yu2qw02l 224 80 continues continue VBZ cord-261058-yu2qw02l 224 81 Increased increase VBN cord-261058-yu2qw02l 224 82 frequency frequency NN cord-261058-yu2qw02l 224 83 of of IN cord-261058-yu2qw02l 224 84 alleles allele NNS cord-261058-yu2qw02l 224 85 associated associate VBN cord-261058-yu2qw02l 224 86 with with IN cord-261058-yu2qw02l 224 87 elevated elevated JJ cord-261058-yu2qw02l 224 88 tumor tumor NN cord-261058-yu2qw02l 224 89 necrosis necrosis NN cord-261058-yu2qw02l 224 90 factor factor NN cord-261058-yu2qw02l 224 91 - - HYPH cord-261058-yu2qw02l 224 92 alpha alpha NN cord-261058-yu2qw02l 224 93 levels level NNS cord-261058-yu2qw02l 224 94 in in IN cord-261058-yu2qw02l 224 95 children child NNS cord-261058-yu2qw02l 224 96 with with IN cord-261058-yu2qw02l 224 97 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 224 98 disease disease NN cord-261058-yu2qw02l 224 99 High high JJ cord-261058-yu2qw02l 224 100 incidence incidence NN cord-261058-yu2qw02l 224 101 of of IN cord-261058-yu2qw02l 224 102 angiotensin angiotensin NN cord-261058-yu2qw02l 224 103 I -PRON- PRP cord-261058-yu2qw02l 224 104 converting convert VBG cord-261058-yu2qw02l 224 105 enzyme enzyme NN cord-261058-yu2qw02l 224 106 genotype genotype NN cord-261058-yu2qw02l 224 107 II II NNP cord-261058-yu2qw02l 224 108 in in IN cord-261058-yu2qw02l 224 109 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 224 110 disease disease NN cord-261058-yu2qw02l 224 111 patients patient NNS cord-261058-yu2qw02l 224 112 with with IN cord-261058-yu2qw02l 224 113 coronary coronary JJ cord-261058-yu2qw02l 224 114 aneurysm aneurysm NN cord-261058-yu2qw02l 224 115 Methylenetetrahydrofolate Methylenetetrahydrofolate NNP cord-261058-yu2qw02l 224 116 reductase reductase NN cord-261058-yu2qw02l 224 117 polymorphism polymorphism NN cord-261058-yu2qw02l 224 118 in in IN cord-261058-yu2qw02l 224 119 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 224 120 disease disease NN cord-261058-yu2qw02l 224 121 HLA HLA NNP cord-261058-yu2qw02l 224 122 antigens antigen NNS cord-261058-yu2qw02l 224 123 in in IN cord-261058-yu2qw02l 224 124 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 224 125 disease disease NN cord-261058-yu2qw02l 224 126 HLA HLA NNP cord-261058-yu2qw02l 224 127 antigens antigen NNS cord-261058-yu2qw02l 224 128 in in IN cord-261058-yu2qw02l 224 129 mucocutaneous mucocutaneous JJ cord-261058-yu2qw02l 224 130 lymph lymph NN cord-261058-yu2qw02l 224 131 node node NN cord-261058-yu2qw02l 224 132 syndrome syndrome NN cord-261058-yu2qw02l 224 133 in in IN cord-261058-yu2qw02l 224 134 New New NNP cord-261058-yu2qw02l 224 135 England England NNP cord-261058-yu2qw02l 224 136 Problems Problems NNPS cord-261058-yu2qw02l 224 137 of of IN cord-261058-yu2qw02l 224 138 reporting report VBG cord-261058-yu2qw02l 224 139 genetic genetic JJ cord-261058-yu2qw02l 224 140 associations association NNS cord-261058-yu2qw02l 224 141 with with IN cord-261058-yu2qw02l 224 142 complex complex JJ cord-261058-yu2qw02l 224 143 outcomes outcome NNS cord-261058-yu2qw02l 225 1 The the DT cord-261058-yu2qw02l 225 2 HLA HLA NNP cord-261058-yu2qw02l 225 3 class class NN cord-261058-yu2qw02l 225 4 II II NNP cord-261058-yu2qw02l 225 5 region region NN cord-261058-yu2qw02l 225 6 and and CC cord-261058-yu2qw02l 225 7 susceptibility susceptibility NN cord-261058-yu2qw02l 225 8 to to IN cord-261058-yu2qw02l 225 9 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 225 10 disease disease NN cord-261058-yu2qw02l 225 11 Polymorphism polymorphism NN cord-261058-yu2qw02l 225 12 of of IN cord-261058-yu2qw02l 225 13 transmembrane transmembrane NNP cord-261058-yu2qw02l 225 14 region region NN cord-261058-yu2qw02l 225 15 of of IN cord-261058-yu2qw02l 225 16 MICA MICA NNP cord-261058-yu2qw02l 225 17 gene gene NN cord-261058-yu2qw02l 225 18 and and CC cord-261058-yu2qw02l 225 19 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 225 20 disease disease NN cord-261058-yu2qw02l 225 21 Polymorphism polymorphism NN cord-261058-yu2qw02l 225 22 of of IN cord-261058-yu2qw02l 225 23 SLC11A1 SLC11A1 NNP cord-261058-yu2qw02l 226 1 ( ( -LRB- cord-261058-yu2qw02l 226 2 formerly formerly RB cord-261058-yu2qw02l 226 3 NRAMP1 nramp1 DT cord-261058-yu2qw02l 226 4 ) ) -RRB- cord-261058-yu2qw02l 227 1 gene gene NN cord-261058-yu2qw02l 227 2 confers confer VBZ cord-261058-yu2qw02l 227 3 susceptibility susceptibility NN cord-261058-yu2qw02l 227 4 to to IN cord-261058-yu2qw02l 227 5 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 227 6 disease disease NN cord-261058-yu2qw02l 227 7 Mapping mapping NN cord-261058-yu2qw02l 227 8 disease disease NN cord-261058-yu2qw02l 227 9 genes gene NNS cord-261058-yu2qw02l 227 10 : : : cord-261058-yu2qw02l 227 11 family family NN cord-261058-yu2qw02l 227 12 - - HYPH cord-261058-yu2qw02l 227 13 based base VBN cord-261058-yu2qw02l 227 14 association association NN cord-261058-yu2qw02l 227 15 studies study NNS cord-261058-yu2qw02l 227 16 Control Control NNP cord-261058-yu2qw02l 227 17 of of IN cord-261058-yu2qw02l 227 18 confounding confound VBG cord-261058-yu2qw02l 227 19 of of IN cord-261058-yu2qw02l 227 20 genetic genetic JJ cord-261058-yu2qw02l 227 21 associations association NNS cord-261058-yu2qw02l 227 22 in in IN cord-261058-yu2qw02l 227 23 stratified stratified JJ cord-261058-yu2qw02l 227 24 populations population NNS cord-261058-yu2qw02l 228 1 The the DT cord-261058-yu2qw02l 228 2 TDT TDT NNP cord-261058-yu2qw02l 228 3 and and CC cord-261058-yu2qw02l 228 4 other other JJ cord-261058-yu2qw02l 228 5 family family NN cord-261058-yu2qw02l 228 6 - - HYPH cord-261058-yu2qw02l 228 7 based base VBN cord-261058-yu2qw02l 228 8 tests test NNS cord-261058-yu2qw02l 228 9 for for IN cord-261058-yu2qw02l 228 10 linkage linkage NN cord-261058-yu2qw02l 228 11 disequilibrium disequilibrium NN cord-261058-yu2qw02l 228 12 and and CC cord-261058-yu2qw02l 228 13 association association NN cord-261058-yu2qw02l 228 14 Identification identification NN cord-261058-yu2qw02l 228 15 of of IN cord-261058-yu2qw02l 228 16 susceptibility susceptibility NN cord-261058-yu2qw02l 228 17 loci locus NNS cord-261058-yu2qw02l 228 18 for for IN cord-261058-yu2qw02l 228 19 insulindependent insulindependent JJ cord-261058-yu2qw02l 228 20 diabetes diabetes NN cord-261058-yu2qw02l 228 21 mellitus mellitus NN cord-261058-yu2qw02l 228 22 by by IN cord-261058-yu2qw02l 228 23 trans trans JJ cord-261058-yu2qw02l 228 24 - - JJ cord-261058-yu2qw02l 228 25 racial racial JJ cord-261058-yu2qw02l 228 26 gene gene NN cord-261058-yu2qw02l 228 27 mapping mapping NN cord-261058-yu2qw02l 228 28 The the DT cord-261058-yu2qw02l 228 29 diagnosis diagnosis NN cord-261058-yu2qw02l 228 30 and and CC cord-261058-yu2qw02l 228 31 management management NN cord-261058-yu2qw02l 228 32 of of IN cord-261058-yu2qw02l 228 33 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 228 34 disease disease NN cord-261058-yu2qw02l 228 35 Adenovirus Adenovirus NNP cord-261058-yu2qw02l 228 36 infection infection NN cord-261058-yu2qw02l 228 37 in in IN cord-261058-yu2qw02l 228 38 patients patient NNS cord-261058-yu2qw02l 228 39 with with IN cord-261058-yu2qw02l 228 40 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 228 41 disease disease NN cord-261058-yu2qw02l 229 1 Could Could MD cord-261058-yu2qw02l 229 2 a a DT cord-261058-yu2qw02l 229 3 herpesvirus herpesvirus NN cord-261058-yu2qw02l 229 4 be be VB cord-261058-yu2qw02l 229 5 the the DT cord-261058-yu2qw02l 229 6 cause cause NN cord-261058-yu2qw02l 229 7 of of IN cord-261058-yu2qw02l 229 8 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 229 9 disease disease NN cord-261058-yu2qw02l 229 10 ? ? . cord-261058-yu2qw02l 230 1 Mycoplasma mycoplasma NN cord-261058-yu2qw02l 230 2 infection infection NN cord-261058-yu2qw02l 230 3 and and CC cord-261058-yu2qw02l 230 4 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 230 5 disease disease NN cord-261058-yu2qw02l 230 6 Probable probable JJ cord-261058-yu2qw02l 230 7 role role NN cord-261058-yu2qw02l 230 8 of of IN cord-261058-yu2qw02l 230 9 Streptococcus streptococcus NN cord-261058-yu2qw02l 230 10 pyogenes pyogene NNS cord-261058-yu2qw02l 230 11 in in IN cord-261058-yu2qw02l 230 12 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 230 13 disease disease NN cord-261058-yu2qw02l 230 14 Serologic Serologic NNP cord-261058-yu2qw02l 230 15 evidence evidence NN cord-261058-yu2qw02l 230 16 that that IN cord-261058-yu2qw02l 230 17 streptococcal streptococcal JJ cord-261058-yu2qw02l 230 18 superantigens superantigen NNS cord-261058-yu2qw02l 230 19 are be VBP cord-261058-yu2qw02l 230 20 not not RB cord-261058-yu2qw02l 230 21 involved involve VBN cord-261058-yu2qw02l 230 22 in in IN cord-261058-yu2qw02l 230 23 the the DT cord-261058-yu2qw02l 230 24 pathogenesis pathogenesis NN cord-261058-yu2qw02l 230 25 of of IN cord-261058-yu2qw02l 230 26 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 230 27 disease disease NN cord-261058-yu2qw02l 230 28 Variant variant NN cord-261058-yu2qw02l 230 29 Streptococcus Streptococcus NNP cord-261058-yu2qw02l 230 30 sanguis sanguis NN cord-261058-yu2qw02l 230 31 as as IN cord-261058-yu2qw02l 230 32 an an DT cord-261058-yu2qw02l 230 33 etiological etiological JJ cord-261058-yu2qw02l 230 34 agent agent NN cord-261058-yu2qw02l 230 35 of of IN cord-261058-yu2qw02l 230 36 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 230 37 disease disease NN cord-261058-yu2qw02l 231 1 Toxic toxic JJ cord-261058-yu2qw02l 231 2 shock shock NN cord-261058-yu2qw02l 231 3 syndrome syndrome NN cord-261058-yu2qw02l 231 4 toxin toxin NN cord-261058-yu2qw02l 231 5 - - HYPH cord-261058-yu2qw02l 231 6 secreting secrete VBG cord-261058-yu2qw02l 231 7 Staphylococcus Staphylococcus NNP cord-261058-yu2qw02l 231 8 aureus aureus NN cord-261058-yu2qw02l 231 9 in in IN cord-261058-yu2qw02l 231 10 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 231 11 syndrome syndrome NN cord-261058-yu2qw02l 232 1 The the DT cord-261058-yu2qw02l 232 2 absence absence NN cord-261058-yu2qw02l 232 3 of of IN cord-261058-yu2qw02l 232 4 evidence evidence NN cord-261058-yu2qw02l 232 5 of of IN cord-261058-yu2qw02l 232 6 staphylococcal staphylococcal JJ cord-261058-yu2qw02l 232 7 toxin toxin NN cord-261058-yu2qw02l 232 8 involvement involvement NN cord-261058-yu2qw02l 232 9 in in IN cord-261058-yu2qw02l 232 10 the the DT cord-261058-yu2qw02l 232 11 pathogenesis pathogenesis NN cord-261058-yu2qw02l 232 12 of of IN cord-261058-yu2qw02l 232 13 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 232 14 disease disease NN cord-261058-yu2qw02l 232 15 Variant variant NN cord-261058-yu2qw02l 232 16 strain strain NN cord-261058-yu2qw02l 232 17 of of IN cord-261058-yu2qw02l 232 18 Propionibacterium propionibacterium NN cord-261058-yu2qw02l 232 19 acnes acne NNS cord-261058-yu2qw02l 232 20 : : : cord-261058-yu2qw02l 232 21 a a DT cord-261058-yu2qw02l 232 22 clue clue NN cord-261058-yu2qw02l 232 23 to to IN cord-261058-yu2qw02l 232 24 the the DT cord-261058-yu2qw02l 232 25 etiology etiology NN cord-261058-yu2qw02l 232 26 of of IN cord-261058-yu2qw02l 232 27 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 232 28 disease disease NN cord-261058-yu2qw02l 232 29 Pathogenicity Pathogenicity NNP cord-261058-yu2qw02l 232 30 of of IN cord-261058-yu2qw02l 232 31 Propionibacterium Propionibacterium NNP cord-261058-yu2qw02l 232 32 acnes acne NNS cord-261058-yu2qw02l 232 33 isolated isolate VBN cord-261058-yu2qw02l 232 34 from from IN cord-261058-yu2qw02l 232 35 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 232 36 disease disease NN cord-261058-yu2qw02l 232 37 patients patient NNS cord-261058-yu2qw02l 232 38 - - HYPH cord-261058-yu2qw02l 232 39 cytopathogenic cytopathogenic JJ cord-261058-yu2qw02l 232 40 protein protein NN cord-261058-yu2qw02l 232 41 ( ( -LRB- cord-261058-yu2qw02l 232 42 CPP CPP NNP cord-261058-yu2qw02l 232 43 ) ) -RRB- cord-261058-yu2qw02l 232 44 isolated isolate VBN cord-261058-yu2qw02l 232 45 from from IN cord-261058-yu2qw02l 232 46 P. P. NNP cord-261058-yu2qw02l 232 47 acnes acnes NNP cord-261058-yu2qw02l 232 48 culture culture NN cord-261058-yu2qw02l 232 49 filtrates filtrates NNP cord-261058-yu2qw02l 232 50 and and CC cord-261058-yu2qw02l 232 51 measurement measurement NN cord-261058-yu2qw02l 232 52 of of IN cord-261058-yu2qw02l 232 53 the the DT cord-261058-yu2qw02l 232 54 antibody antibody NN cord-261058-yu2qw02l 232 55 against against IN cord-261058-yu2qw02l 232 56 CPP CPP NNP cord-261058-yu2qw02l 232 57 Positive positive JJ cord-261058-yu2qw02l 232 58 Ehrlichia Ehrlichia NNP cord-261058-yu2qw02l 232 59 canis canis NN cord-261058-yu2qw02l 232 60 serology serology NN cord-261058-yu2qw02l 232 61 in in IN cord-261058-yu2qw02l 232 62 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 232 63 disease disease NN cord-261058-yu2qw02l 232 64 Ehrlichia Ehrlichia NNP cord-261058-yu2qw02l 232 65 chaffeensis chaffeensis NN cord-261058-yu2qw02l 232 66 and and CC cord-261058-yu2qw02l 232 67 Rochalimaea Rochalimaea NNP cord-261058-yu2qw02l 232 68 antibodies antibody NNS cord-261058-yu2qw02l 232 69 in in IN cord-261058-yu2qw02l 232 70 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 232 71 disease disease NN cord-261058-yu2qw02l 232 72 Rickettsia Rickettsia NNP cord-261058-yu2qw02l 232 73 - - HYPH cord-261058-yu2qw02l 232 74 like like JJ cord-261058-yu2qw02l 232 75 bodies body NNS cord-261058-yu2qw02l 232 76 and and CC cord-261058-yu2qw02l 232 77 splenitis splenitis NN cord-261058-yu2qw02l 232 78 in in IN cord-261058-yu2qw02l 232 79 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 232 80 disease disease NN cord-261058-yu2qw02l 232 81 Failure failure NN cord-261058-yu2qw02l 232 82 to to TO cord-261058-yu2qw02l 232 83 confirm confirm VB cord-261058-yu2qw02l 232 84 the the DT cord-261058-yu2qw02l 232 85 rickettsial rickettsial JJ cord-261058-yu2qw02l 232 86 etiology etiology NN cord-261058-yu2qw02l 232 87 of of IN cord-261058-yu2qw02l 232 88 MCLS MCLS NNP cord-261058-yu2qw02l 233 1 ( ( -LRB- cord-261058-yu2qw02l 233 2 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 233 3 disease disease NN cord-261058-yu2qw02l 233 4 ) ) -RRB- cord-261058-yu2qw02l 234 1 Epstein Epstein NNP cord-261058-yu2qw02l 234 2 - - HYPH cord-261058-yu2qw02l 234 3 Barr Barr NNP cord-261058-yu2qw02l 234 4 virus virus NN cord-261058-yu2qw02l 234 5 genome genome NN cord-261058-yu2qw02l 234 6 - - HYPH cord-261058-yu2qw02l 234 7 positive positive JJ cord-261058-yu2qw02l 234 8 tubulointerstitial tubulointerstitial JJ cord-261058-yu2qw02l 234 9 nephritis nephritis NN cord-261058-yu2qw02l 234 10 associated associate VBN cord-261058-yu2qw02l 234 11 with with IN cord-261058-yu2qw02l 234 12 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 234 13 disease disease NN cord-261058-yu2qw02l 234 14 - - HYPH cord-261058-yu2qw02l 234 15 like like JJ cord-261058-yu2qw02l 234 16 coronary coronary JJ cord-261058-yu2qw02l 234 17 aneurysms aneurysm NNS cord-261058-yu2qw02l 235 1 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 235 2 disease disease NN cord-261058-yu2qw02l 235 3 , , , cord-261058-yu2qw02l 235 4 Epstein Epstein NNP cord-261058-yu2qw02l 235 5 - - HYPH cord-261058-yu2qw02l 235 6 Barr Barr NNP cord-261058-yu2qw02l 235 7 virus virus NN cord-261058-yu2qw02l 235 8 and and CC cord-261058-yu2qw02l 235 9 coronary coronary JJ cord-261058-yu2qw02l 235 10 artery artery NN cord-261058-yu2qw02l 235 11 aneurysms aneurysm NNS cord-261058-yu2qw02l 236 1 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 236 2 disease disease NN cord-261058-yu2qw02l 236 3 and and CC cord-261058-yu2qw02l 236 4 Epstein Epstein NNP cord-261058-yu2qw02l 236 5 - - HYPH cord-261058-yu2qw02l 236 6 Barr Barr NNP cord-261058-yu2qw02l 236 7 virus virus NN cord-261058-yu2qw02l 237 1 The the DT cord-261058-yu2qw02l 237 2 etiology etiology NN cord-261058-yu2qw02l 237 3 of of IN cord-261058-yu2qw02l 237 4 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 237 5 disease disease NN cord-261058-yu2qw02l 237 6 : : : cord-261058-yu2qw02l 237 7 retrovirus retrovirus NN cord-261058-yu2qw02l 237 8 ? ? . cord-261058-yu2qw02l 238 1 Polymerase polymerase NN cord-261058-yu2qw02l 238 2 activity activity NN cord-261058-yu2qw02l 238 3 in in IN cord-261058-yu2qw02l 238 4 lymphocyte lymphocyte NN cord-261058-yu2qw02l 238 5 culture culture NN cord-261058-yu2qw02l 238 6 supernatants supernatant NNS cord-261058-yu2qw02l 238 7 from from IN cord-261058-yu2qw02l 238 8 patients patient NNS cord-261058-yu2qw02l 238 9 with with IN cord-261058-yu2qw02l 238 10 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 238 11 disease disease NN cord-261058-yu2qw02l 238 12 Virus virus NN cord-261058-yu2qw02l 238 13 - - HYPH cord-261058-yu2qw02l 238 14 like like JJ cord-261058-yu2qw02l 238 15 particles particle NNS cord-261058-yu2qw02l 238 16 with with IN cord-261058-yu2qw02l 238 17 reverse reverse JJ cord-261058-yu2qw02l 238 18 transcriptase transcriptase NN cord-261058-yu2qw02l 238 19 activity activity NN cord-261058-yu2qw02l 238 20 associated associate VBN cord-261058-yu2qw02l 238 21 with with IN cord-261058-yu2qw02l 238 22 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 238 23 disease disease NN cord-261058-yu2qw02l 239 1 A a DT cord-261058-yu2qw02l 239 2 measles measle NNS cord-261058-yu2qw02l 239 3 virus virus NN cord-261058-yu2qw02l 239 4 isolate isolate VBP cord-261058-yu2qw02l 239 5 from from IN cord-261058-yu2qw02l 239 6 a a DT cord-261058-yu2qw02l 239 7 child child NN cord-261058-yu2qw02l 239 8 with with IN cord-261058-yu2qw02l 239 9 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 239 10 disease disease NN cord-261058-yu2qw02l 239 11 : : : cord-261058-yu2qw02l 240 1 sequence sequence NN cord-261058-yu2qw02l 240 2 comparison comparison NN cord-261058-yu2qw02l 240 3 with with IN cord-261058-yu2qw02l 240 4 contemporaneous contemporaneous JJ cord-261058-yu2qw02l 240 5 isolates isolate NNS cord-261058-yu2qw02l 240 6 from from IN cord-261058-yu2qw02l 240 7 ' ' `` cord-261058-yu2qw02l 240 8 classical classical JJ cord-261058-yu2qw02l 240 9 ' ' '' cord-261058-yu2qw02l 240 10 cases case NNS cord-261058-yu2qw02l 240 11 Isolation isolation NN cord-261058-yu2qw02l 240 12 of of IN cord-261058-yu2qw02l 240 13 measles measle NNS cord-261058-yu2qw02l 240 14 virus virus NN cord-261058-yu2qw02l 240 15 from from IN cord-261058-yu2qw02l 240 16 child child NN cord-261058-yu2qw02l 240 17 with with IN cord-261058-yu2qw02l 240 18 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 240 19 disease disease NN cord-261058-yu2qw02l 240 20 Demonstration demonstration NN cord-261058-yu2qw02l 240 21 of of IN cord-261058-yu2qw02l 240 22 Chlamydia Chlamydia NNP cord-261058-yu2qw02l 240 23 pneumoniae pneumoniae NN cord-261058-yu2qw02l 240 24 in in IN cord-261058-yu2qw02l 240 25 cardiovascular cardiovascular JJ cord-261058-yu2qw02l 240 26 tissues tissue NNS cord-261058-yu2qw02l 240 27 from from IN cord-261058-yu2qw02l 240 28 children child NNS cord-261058-yu2qw02l 240 29 with with IN cord-261058-yu2qw02l 240 30 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 240 31 disease disease NN cord-261058-yu2qw02l 240 32 Is be VBZ cord-261058-yu2qw02l 240 33 there there EX cord-261058-yu2qw02l 240 34 an an DT cord-261058-yu2qw02l 240 35 association association NN cord-261058-yu2qw02l 240 36 between between IN cord-261058-yu2qw02l 240 37 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 240 38 disease disease NN cord-261058-yu2qw02l 240 39 and and CC cord-261058-yu2qw02l 240 40 Chlamydia Chlamydia NNP cord-261058-yu2qw02l 240 41 pneumoniae pneumoniae NN cord-261058-yu2qw02l 240 42 Failure failure NN cord-261058-yu2qw02l 240 43 to to TO cord-261058-yu2qw02l 240 44 demonstrate demonstrate VB cord-261058-yu2qw02l 240 45 Chlamydia Chlamydia NNP cord-261058-yu2qw02l 240 46 pneumoniae pneumoniae NN cord-261058-yu2qw02l 240 47 in in IN cord-261058-yu2qw02l 240 48 cardiovascular cardiovascular JJ cord-261058-yu2qw02l 240 49 tissue tissue NN cord-261058-yu2qw02l 240 50 from from IN cord-261058-yu2qw02l 240 51 children child NNS cord-261058-yu2qw02l 240 52 with with IN cord-261058-yu2qw02l 240 53 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 240 54 disease disease NN cord-261058-yu2qw02l 241 1 Is be VBZ cord-261058-yu2qw02l 241 2 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 241 3 disease disease NN cord-261058-yu2qw02l 241 4 a a DT cord-261058-yu2qw02l 241 5 variant variant NN cord-261058-yu2qw02l 241 6 of of IN cord-261058-yu2qw02l 241 7 Q Q NNP cord-261058-yu2qw02l 241 8 fever fever NN cord-261058-yu2qw02l 241 9 ? ? . cord-261058-yu2qw02l 242 1 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 242 2 disease disease NN cord-261058-yu2qw02l 242 3 in in IN cord-261058-yu2qw02l 242 4 European european JJ cord-261058-yu2qw02l 242 5 adult adult NN cord-261058-yu2qw02l 242 6 associated associate VBN cord-261058-yu2qw02l 242 7 with with IN cord-261058-yu2qw02l 242 8 serological serological JJ cord-261058-yu2qw02l 242 9 response response NN cord-261058-yu2qw02l 242 10 to to IN cord-261058-yu2qw02l 242 11 Coxiella Coxiella NNP cord-261058-yu2qw02l 242 12 burneti burneti NNP cord-261058-yu2qw02l 242 13 Role Role NNP cord-261058-yu2qw02l 242 14 of of IN cord-261058-yu2qw02l 242 15 house house NN cord-261058-yu2qw02l 242 16 dust dust NN cord-261058-yu2qw02l 242 17 mites mite NNS cord-261058-yu2qw02l 242 18 in in IN cord-261058-yu2qw02l 242 19 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 242 20 disease disease NN cord-261058-yu2qw02l 242 21 Urine Urine VBZ cord-261058-yu2qw02l 242 22 mercury mercury NN cord-261058-yu2qw02l 242 23 levels level NNS cord-261058-yu2qw02l 242 24 in in IN cord-261058-yu2qw02l 242 25 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 242 26 disease disease NN cord-261058-yu2qw02l 242 27 Rug rug NN cord-261058-yu2qw02l 242 28 shampoo shampoo NN cord-261058-yu2qw02l 242 29 and and CC cord-261058-yu2qw02l 242 30 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 242 31 disease disease NN cord-261058-yu2qw02l 242 32 Association Association NNP cord-261058-yu2qw02l 242 33 of of IN cord-261058-yu2qw02l 242 34 rug rug NN cord-261058-yu2qw02l 242 35 shampooing shampooing NN cord-261058-yu2qw02l 242 36 and and CC cord-261058-yu2qw02l 242 37 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 242 38 disease disease NN cord-261058-yu2qw02l 242 39 Clinical clinical JJ cord-261058-yu2qw02l 242 40 and and CC cord-261058-yu2qw02l 242 41 epidemiologic epidemiologic JJ cord-261058-yu2qw02l 242 42 characteristics characteristic NNS cord-261058-yu2qw02l 242 43 of of IN cord-261058-yu2qw02l 242 44 patients patient NNS cord-261058-yu2qw02l 242 45 referred refer VBN cord-261058-yu2qw02l 242 46 for for IN cord-261058-yu2qw02l 242 47 evaluation evaluation NN cord-261058-yu2qw02l 242 48 of of IN cord-261058-yu2qw02l 242 49 possible possible JJ cord-261058-yu2qw02l 242 50 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 242 51 disease disease NN cord-261058-yu2qw02l 242 52 . . . cord-261058-yu2qw02l 243 1 United United NNP cord-261058-yu2qw02l 243 2 States States NNP cord-261058-yu2qw02l 243 3 Multicenter Multicenter NNP cord-261058-yu2qw02l 243 4 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 243 5 Disease Disease NNP cord-261058-yu2qw02l 243 6 Study Study NNP cord-261058-yu2qw02l 243 7 Group Group NNP cord-261058-yu2qw02l 244 1 The the DT cord-261058-yu2qw02l 244 2 authors author NNS cord-261058-yu2qw02l 244 3 ' ' POS cord-261058-yu2qw02l 244 4 Kawasaki Kawasaki NNP cord-261058-yu2qw02l 244 5 _SP