id author title date pages extension mime words sentences flesch summary cache txt cord-308080-1heu9vuv Simulundu, Edgar First COVID-19 Case in Zambia – Comparative phylogenomic analyses of SARS-CoV-2 detected in African countries 2020-10-06 .txt text/plain 1714 99 52 title: First COVID-19 Case in Zambia – Comparative phylogenomic analyses of SARS-CoV-2 detected in African countries Contact tracing showed that SARS-CoV-2 infection was contained within the patient's household, with no further spread to attending health care workers or community members. Whole genome sequence analysis should be part of all surveillance and case detection activities in order to monitor the origin and evolution of SARS-CoV-2 lineages across Africa. We report the identification and clinical management of the first COVID-19 case from Zambia, and present the phylogenetic analyses of the patient's SARS-CoV-2 isolate, comparing it to other SARS-CoV-2 lineages reported from other African countries. Phylogenomic analysis showed that the detected SARS-CoV-2 belonged to lineage B.1.1, sharing the most common recent ancestor with viruses detected in South Africa (Figure 2) Wuhan-Hu-1, which included the D614G mutation which has been observed to correlate with increased case fatality rates. ./cache/cord-308080-1heu9vuv.txt ./txt/cord-308080-1heu9vuv.txt