id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002138-uywz5nqw	Boëlle, Pierre‐Yves	Transmission parameters of the A/H1N1 (2009) influenza virus pandemic: a review	2011-03-31		.txt	text/plain	4542	293	56	Methods We reviewed all studies presenting estimates of the serial interval or generation time and the reproduction number of the A/H1N1 (2009) virus infection. Accounting for under‐reporting in the early period of the pandemic and limiting variation because of the choice of the generation time interval, the reproduction number was between 1·2 and 2·3 with median 1·5. In the guidance document 'Global surveillance during an influenza pandemic' released by the World Health Organization, three parameters were highlighted that should be documented quickly in this respect: the incubation period (time between infection and symptoms), the serial interval (time between symptoms onset in primary case and secondary case), and the reproduction ratio ⁄ number (average number of secondary cases per primary case). Indeed, before 2009, the two best documented values for the mean SI concerned seasonal influenza, with two estimates obtained in household-based studies: 2AE6 days (CI 95% 2AE1, 3AE0) 6 and 3AE6 days (CI 95% [2AE9, 4AE3]) 5 ; no information was available for past pandemics.	./cache/cord-002138-uywz5nqw.txt	./txt/cord-002138-uywz5nqw.txt