id sid tid token lemma pos cord-318625-hf7fgtnp 1 1 key key NN cord-318625-hf7fgtnp 1 2 : : : cord-318625-hf7fgtnp 2 1 cord-318625-hf7fgtnp cord-318625-hf7fgtnp . cord-318625-hf7fgtnp 3 1 authors author NNS cord-318625-hf7fgtnp 3 2 : : : cord-318625-hf7fgtnp 3 3 Vashi Vashi NNP cord-318625-hf7fgtnp 3 4 , , , cord-318625-hf7fgtnp 3 5 Yoya Yoya NNP cord-318625-hf7fgtnp 3 6 ; ; : cord-318625-hf7fgtnp 3 7 Jagrit Jagrit NNP cord-318625-hf7fgtnp 3 8 , , , cord-318625-hf7fgtnp 3 9 Vipin Vipin NNP cord-318625-hf7fgtnp 3 10 ; ; : cord-318625-hf7fgtnp 3 11 Kumar Kumar NNP cord-318625-hf7fgtnp 3 12 , , , cord-318625-hf7fgtnp 4 1 Sachin Sachin NNP cord-318625-hf7fgtnp 4 2 title title NN cord-318625-hf7fgtnp 4 3 : : : cord-318625-hf7fgtnp 5 1 Understanding understand VBG cord-318625-hf7fgtnp 5 2 the the DT cord-318625-hf7fgtnp 5 3 B B NNP cord-318625-hf7fgtnp 5 4 and and CC cord-318625-hf7fgtnp 5 5 T T NNP cord-318625-hf7fgtnp 5 6 cell cell NN cord-318625-hf7fgtnp 5 7 epitopes epitope NNS cord-318625-hf7fgtnp 5 8 of of IN cord-318625-hf7fgtnp 5 9 spike spike NN cord-318625-hf7fgtnp 5 10 protein protein NN cord-318625-hf7fgtnp 5 11 of of IN cord-318625-hf7fgtnp 5 12 severe severe JJ cord-318625-hf7fgtnp 5 13 acute acute JJ cord-318625-hf7fgtnp 5 14 respiratory respiratory JJ cord-318625-hf7fgtnp 5 15 syndrome syndrome NN cord-318625-hf7fgtnp 5 16 coronavirus-2 coronavirus-2 NN cord-318625-hf7fgtnp 5 17 : : : cord-318625-hf7fgtnp 6 1 A a DT cord-318625-hf7fgtnp 6 2 computational computational JJ cord-318625-hf7fgtnp 6 3 way way NN cord-318625-hf7fgtnp 6 4 to to TO cord-318625-hf7fgtnp 6 5 predict predict VB cord-318625-hf7fgtnp 6 6 the the DT cord-318625-hf7fgtnp 6 7 immunogens immunogens JJ cord-318625-hf7fgtnp 6 8 date date NN cord-318625-hf7fgtnp 6 9 : : : cord-318625-hf7fgtnp 6 10 2020 2020 CD cord-318625-hf7fgtnp 6 11 - - HYPH cord-318625-hf7fgtnp 6 12 05 05 CD cord-318625-hf7fgtnp 6 13 - - HYPH cord-318625-hf7fgtnp 6 14 27 27 CD cord-318625-hf7fgtnp 6 15 journal journal NN cord-318625-hf7fgtnp 6 16 : : : cord-318625-hf7fgtnp 7 1 Infect infect VB cord-318625-hf7fgtnp 7 2 Genet Genet NNP cord-318625-hf7fgtnp 7 3 Evol Evol NNP cord-318625-hf7fgtnp 7 4 DOI doi NN cord-318625-hf7fgtnp 7 5 : : : cord-318625-hf7fgtnp 7 6 10.1016/ 10.1016/ CD cord-318625-hf7fgtnp 8 1 j.meegid.2020.104382 j.meegid.2020.104382 NFP cord-318625-hf7fgtnp 8 2 sha sha NNP cord-318625-hf7fgtnp 8 3 : : : cord-318625-hf7fgtnp 8 4 f6f03679898f1ab4fd917301297b8b266360320d f6f03679898f1ab4fd917301297b8b266360320d NFP cord-318625-hf7fgtnp 8 5 doc_id doc_id CD cord-318625-hf7fgtnp 8 6 : : : cord-318625-hf7fgtnp 8 7 318625 318625 CD cord-318625-hf7fgtnp 8 8 cord_uid cord_uid NNS cord-318625-hf7fgtnp 8 9 : : : cord-318625-hf7fgtnp 9 1 hf7fgtnp hf7fgtnp . cord-318625-hf7fgtnp 10 1 The the DT cord-318625-hf7fgtnp 10 2 2019 2019 CD cord-318625-hf7fgtnp 10 3 novel novel NN cord-318625-hf7fgtnp 10 4 severe severe JJ cord-318625-hf7fgtnp 10 5 acute acute JJ cord-318625-hf7fgtnp 10 6 respiratory respiratory JJ cord-318625-hf7fgtnp 10 7 syndrome syndrome NN cord-318625-hf7fgtnp 10 8 coronavirus-2 coronavirus-2 NN cord-318625-hf7fgtnp 11 1 ( ( -LRB- cord-318625-hf7fgtnp 11 2 SARS SARS NNP cord-318625-hf7fgtnp 11 3 - - HYPH cord-318625-hf7fgtnp 11 4 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 11 5 ) ) -RRB- cord-318625-hf7fgtnp 11 6 outbreak outbreak NN cord-318625-hf7fgtnp 11 7 has have VBZ cord-318625-hf7fgtnp 11 8 caused cause VBN cord-318625-hf7fgtnp 11 9 a a DT cord-318625-hf7fgtnp 11 10 large large JJ cord-318625-hf7fgtnp 11 11 number number NN cord-318625-hf7fgtnp 11 12 of of IN cord-318625-hf7fgtnp 11 13 deaths death NNS cord-318625-hf7fgtnp 11 14 , , , cord-318625-hf7fgtnp 11 15 with with IN cord-318625-hf7fgtnp 11 16 thousands thousand NNS cord-318625-hf7fgtnp 11 17 of of IN cord-318625-hf7fgtnp 11 18 confirmed confirm VBN cord-318625-hf7fgtnp 11 19 cases case NNS cord-318625-hf7fgtnp 11 20 worldwide worldwide RB cord-318625-hf7fgtnp 11 21 . . . cord-318625-hf7fgtnp 12 1 The the DT cord-318625-hf7fgtnp 12 2 present present JJ cord-318625-hf7fgtnp 12 3 study study NN cord-318625-hf7fgtnp 12 4 followed follow VBD cord-318625-hf7fgtnp 12 5 computational computational JJ cord-318625-hf7fgtnp 12 6 approaches approach NNS cord-318625-hf7fgtnp 12 7 to to TO cord-318625-hf7fgtnp 12 8 identify identify VB cord-318625-hf7fgtnp 12 9 B- B- NNP cord-318625-hf7fgtnp 12 10 and and CC cord-318625-hf7fgtnp 12 11 T t NN cord-318625-hf7fgtnp 12 12 - - HYPH cord-318625-hf7fgtnp 12 13 cell cell NN cord-318625-hf7fgtnp 12 14 epitopes epitope NNS cord-318625-hf7fgtnp 12 15 for for IN cord-318625-hf7fgtnp 12 16 the the DT cord-318625-hf7fgtnp 12 17 spike spike NN cord-318625-hf7fgtnp 12 18 ( ( -LRB- cord-318625-hf7fgtnp 12 19 S s NN cord-318625-hf7fgtnp 12 20 ) ) -RRB- cord-318625-hf7fgtnp 12 21 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 12 22 of of IN cord-318625-hf7fgtnp 12 23 SARS SARS NNP cord-318625-hf7fgtnp 12 24 - - HYPH cord-318625-hf7fgtnp 12 25 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 12 26 by by IN cord-318625-hf7fgtnp 12 27 its -PRON- PRP$ cord-318625-hf7fgtnp 12 28 interactions interaction NNS cord-318625-hf7fgtnp 12 29 with with IN cord-318625-hf7fgtnp 12 30 the the DT cord-318625-hf7fgtnp 12 31 human human JJ cord-318625-hf7fgtnp 12 32 leukocyte leukocyte NN cord-318625-hf7fgtnp 12 33 antigen antigen NN cord-318625-hf7fgtnp 12 34 alleles allele NNS cord-318625-hf7fgtnp 12 35 . . . cord-318625-hf7fgtnp 13 1 We -PRON- PRP cord-318625-hf7fgtnp 13 2 identified identify VBD cord-318625-hf7fgtnp 13 3 24 24 CD cord-318625-hf7fgtnp 13 4 peptide peptide NN cord-318625-hf7fgtnp 13 5 stretches stretch NNS cord-318625-hf7fgtnp 13 6 on on IN cord-318625-hf7fgtnp 13 7 the the DT cord-318625-hf7fgtnp 13 8 SARS SARS NNP cord-318625-hf7fgtnp 13 9 - - HYPH cord-318625-hf7fgtnp 13 10 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 13 11 S S NNP cord-318625-hf7fgtnp 13 12 protein protein NN cord-318625-hf7fgtnp 13 13 that that WDT cord-318625-hf7fgtnp 13 14 are be VBP cord-318625-hf7fgtnp 13 15 well well RB cord-318625-hf7fgtnp 13 16 conserved conserve VBN cord-318625-hf7fgtnp 13 17 among among IN cord-318625-hf7fgtnp 13 18 the the DT cord-318625-hf7fgtnp 13 19 reported report VBN cord-318625-hf7fgtnp 13 20 strains strain NNS cord-318625-hf7fgtnp 13 21 . . . cord-318625-hf7fgtnp 14 1 The the DT cord-318625-hf7fgtnp 14 2 S S NNP cord-318625-hf7fgtnp 14 3 protein protein NN cord-318625-hf7fgtnp 14 4 structure structure NN cord-318625-hf7fgtnp 14 5 further further RB cord-318625-hf7fgtnp 14 6 validated validate VBD cord-318625-hf7fgtnp 14 7 the the DT cord-318625-hf7fgtnp 14 8 presence presence NN cord-318625-hf7fgtnp 14 9 of of IN cord-318625-hf7fgtnp 14 10 predicted predict VBN cord-318625-hf7fgtnp 14 11 peptides peptide NNS cord-318625-hf7fgtnp 14 12 on on IN cord-318625-hf7fgtnp 14 13 the the DT cord-318625-hf7fgtnp 14 14 surface surface NN cord-318625-hf7fgtnp 14 15 , , , cord-318625-hf7fgtnp 14 16 of of IN cord-318625-hf7fgtnp 14 17 which which WDT cord-318625-hf7fgtnp 14 18 20 20 CD cord-318625-hf7fgtnp 14 19 are be VBP cord-318625-hf7fgtnp 14 20 surface surface NN cord-318625-hf7fgtnp 14 21 exposed expose VBN cord-318625-hf7fgtnp 14 22 and and CC cord-318625-hf7fgtnp 14 23 predicted predict VBN cord-318625-hf7fgtnp 14 24 to to TO cord-318625-hf7fgtnp 14 25 have have VB cord-318625-hf7fgtnp 14 26 reasonable reasonable JJ cord-318625-hf7fgtnp 14 27 epitope epitope NN cord-318625-hf7fgtnp 14 28 binding bind VBG cord-318625-hf7fgtnp 14 29 efficiency efficiency NN cord-318625-hf7fgtnp 14 30 . . . cord-318625-hf7fgtnp 15 1 The the DT cord-318625-hf7fgtnp 15 2 work work NN cord-318625-hf7fgtnp 15 3 could could MD cord-318625-hf7fgtnp 15 4 be be VB cord-318625-hf7fgtnp 15 5 useful useful JJ cord-318625-hf7fgtnp 15 6 for for IN cord-318625-hf7fgtnp 15 7 understanding understand VBG cord-318625-hf7fgtnp 15 8 the the DT cord-318625-hf7fgtnp 15 9 immunodominant immunodominant JJ cord-318625-hf7fgtnp 15 10 regions region NNS cord-318625-hf7fgtnp 15 11 in in IN cord-318625-hf7fgtnp 15 12 the the DT cord-318625-hf7fgtnp 15 13 surface surface NN cord-318625-hf7fgtnp 15 14 protein protein NN cord-318625-hf7fgtnp 15 15 of of IN cord-318625-hf7fgtnp 15 16 SARS SARS NNP cord-318625-hf7fgtnp 15 17 - - HYPH cord-318625-hf7fgtnp 15 18 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 15 19 and and CC cord-318625-hf7fgtnp 15 20 could could MD cord-318625-hf7fgtnp 15 21 potentially potentially RB cord-318625-hf7fgtnp 15 22 help help VB cord-318625-hf7fgtnp 15 23 in in IN cord-318625-hf7fgtnp 15 24 designing design VBG cord-318625-hf7fgtnp 15 25 some some DT cord-318625-hf7fgtnp 15 26 peptide peptide NN cord-318625-hf7fgtnp 15 27 - - HYPH cord-318625-hf7fgtnp 15 28 based base VBN cord-318625-hf7fgtnp 15 29 diagnostics diagnostic NNS cord-318625-hf7fgtnp 15 30 . . . cord-318625-hf7fgtnp 16 1 Also also RB cord-318625-hf7fgtnp 16 2 , , , cord-318625-hf7fgtnp 16 3 identified identify VBD cord-318625-hf7fgtnp 16 4 T t NN cord-318625-hf7fgtnp 16 5 - - HYPH cord-318625-hf7fgtnp 16 6 cell cell NN cord-318625-hf7fgtnp 16 7 epitopes epitope NNS cord-318625-hf7fgtnp 16 8 might may MD cord-318625-hf7fgtnp 16 9 be be VB cord-318625-hf7fgtnp 16 10 considered consider VBN cord-318625-hf7fgtnp 16 11 for for IN cord-318625-hf7fgtnp 16 12 incorporation incorporation NN cord-318625-hf7fgtnp 16 13 in in IN cord-318625-hf7fgtnp 16 14 vaccine vaccine NN cord-318625-hf7fgtnp 16 15 designs design NNS cord-318625-hf7fgtnp 16 16 . . . cord-318625-hf7fgtnp 17 1 Emerging emerge VBG cord-318625-hf7fgtnp 17 2 severe severe JJ cord-318625-hf7fgtnp 17 3 acute acute JJ cord-318625-hf7fgtnp 17 4 respiratory respiratory JJ cord-318625-hf7fgtnp 17 5 syndrome syndrome NN cord-318625-hf7fgtnp 17 6 coronavirus-2 coronavirus-2 NN cord-318625-hf7fgtnp 18 1 ( ( -LRB- cord-318625-hf7fgtnp 18 2 SARS SARS NNP cord-318625-hf7fgtnp 18 3 - - HYPH cord-318625-hf7fgtnp 18 4 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 18 5 ) ) -RRB- cord-318625-hf7fgtnp 18 6 is be VBZ cord-318625-hf7fgtnp 18 7 a a DT cord-318625-hf7fgtnp 18 8 recent recent JJ cord-318625-hf7fgtnp 18 9 pandemic pandemic NN cord-318625-hf7fgtnp 18 10 and and CC cord-318625-hf7fgtnp 18 11 has have VBZ cord-318625-hf7fgtnp 18 12 been be VBN cord-318625-hf7fgtnp 18 13 declared declare VBN cord-318625-hf7fgtnp 18 14 as as IN cord-318625-hf7fgtnp 18 15 a a DT cord-318625-hf7fgtnp 18 16 public public JJ cord-318625-hf7fgtnp 18 17 health health NN cord-318625-hf7fgtnp 18 18 emergency emergency NN cord-318625-hf7fgtnp 18 19 by by IN cord-318625-hf7fgtnp 18 20 the the DT cord-318625-hf7fgtnp 18 21 World World NNP cord-318625-hf7fgtnp 18 22 Health Health NNP cord-318625-hf7fgtnp 18 23 Organization Organization NNP cord-318625-hf7fgtnp 18 24 ( ( -LRB- cord-318625-hf7fgtnp 18 25 ( ( -LRB- cord-318625-hf7fgtnp 18 26 WHO who WP cord-318625-hf7fgtnp 18 27 , , , cord-318625-hf7fgtnp 18 28 2020b 2020b CD cord-318625-hf7fgtnp 18 29 ) ) -RRB- cord-318625-hf7fgtnp 18 30 . . . cord-318625-hf7fgtnp 19 1 The the DT cord-318625-hf7fgtnp 19 2 disease disease NN cord-318625-hf7fgtnp 19 3 rapidly rapidly RB cord-318625-hf7fgtnp 19 4 spread spread VBD cord-318625-hf7fgtnp 19 5 across across IN cord-318625-hf7fgtnp 19 6 the the DT cord-318625-hf7fgtnp 19 7 globe globe NN cord-318625-hf7fgtnp 19 8 and and CC cord-318625-hf7fgtnp 19 9 caused cause VBD cord-318625-hf7fgtnp 19 10 havoc havoc NN cord-318625-hf7fgtnp 19 11 to to IN cord-318625-hf7fgtnp 19 12 humanity humanity NN cord-318625-hf7fgtnp 19 13 ( ( -LRB- cord-318625-hf7fgtnp 19 14 Wu Wu NNP cord-318625-hf7fgtnp 19 15 and and CC cord-318625-hf7fgtnp 19 16 McGoogan McGoogan NNP cord-318625-hf7fgtnp 19 17 , , , cord-318625-hf7fgtnp 19 18 2020 2020 CD cord-318625-hf7fgtnp 19 19 ) ) -RRB- cord-318625-hf7fgtnp 19 20 . . . cord-318625-hf7fgtnp 20 1 By by IN cord-318625-hf7fgtnp 20 2 the the DT cord-318625-hf7fgtnp 20 3 start start NN cord-318625-hf7fgtnp 20 4 of of IN cord-318625-hf7fgtnp 20 5 May May NNP cord-318625-hf7fgtnp 20 6 , , , cord-318625-hf7fgtnp 20 7 SARS SARS NNP cord-318625-hf7fgtnp 20 8 - - HYPH cord-318625-hf7fgtnp 20 9 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 20 10 had have VBD cord-318625-hf7fgtnp 20 11 spread spread VBN cord-318625-hf7fgtnp 20 12 to to IN cord-318625-hf7fgtnp 20 13 215 215 CD cord-318625-hf7fgtnp 20 14 countries country NNS cord-318625-hf7fgtnp 20 15 and and CC cord-318625-hf7fgtnp 20 16 infected infect VBN cord-318625-hf7fgtnp 20 17 over over IN cord-318625-hf7fgtnp 20 18 3,862,676 3,862,676 CD cord-318625-hf7fgtnp 20 19 people people NNS cord-318625-hf7fgtnp 20 20 ( ( -LRB- cord-318625-hf7fgtnp 20 21 WHO who WP cord-318625-hf7fgtnp 20 22 , , , cord-318625-hf7fgtnp 20 23 2020a 2020a CD cord-318625-hf7fgtnp 20 24 ) ) -RRB- cord-318625-hf7fgtnp 20 25 . . . cord-318625-hf7fgtnp 21 1 The the DT cord-318625-hf7fgtnp 21 2 WHO who WP cord-318625-hf7fgtnp 21 3 is be VBZ cord-318625-hf7fgtnp 21 4 continuously continuously RB cord-318625-hf7fgtnp 21 5 monitoring monitor VBG cord-318625-hf7fgtnp 21 6 and and CC cord-318625-hf7fgtnp 21 7 updating update VBG cord-318625-hf7fgtnp 21 8 health health NN cord-318625-hf7fgtnp 21 9 - - HYPH cord-318625-hf7fgtnp 21 10 related relate VBN cord-318625-hf7fgtnp 21 11 plans plan NNS cord-318625-hf7fgtnp 21 12 to to TO cord-318625-hf7fgtnp 21 13 curtail curtail VB cord-318625-hf7fgtnp 21 14 the the DT cord-318625-hf7fgtnp 21 15 disease disease NN cord-318625-hf7fgtnp 21 16 spread spread VB cord-318625-hf7fgtnp 21 17 . . . cord-318625-hf7fgtnp 22 1 The the DT cord-318625-hf7fgtnp 22 2 absence absence NN cord-318625-hf7fgtnp 22 3 of of IN cord-318625-hf7fgtnp 22 4 a a DT cord-318625-hf7fgtnp 22 5 specific specific JJ cord-318625-hf7fgtnp 22 6 treatment treatment NN cord-318625-hf7fgtnp 22 7 and and CC cord-318625-hf7fgtnp 22 8 vaccine vaccine NN cord-318625-hf7fgtnp 22 9 worsens worsen VBZ cord-318625-hf7fgtnp 22 10 the the DT cord-318625-hf7fgtnp 22 11 situation situation NN cord-318625-hf7fgtnp 22 12 and and CC cord-318625-hf7fgtnp 22 13 threatens threaten VBZ cord-318625-hf7fgtnp 22 14 the the DT cord-318625-hf7fgtnp 22 15 world world NN cord-318625-hf7fgtnp 22 16 . . . cord-318625-hf7fgtnp 23 1 The the DT cord-318625-hf7fgtnp 23 2 International International NNP cord-318625-hf7fgtnp 23 3 Committee Committee NNP cord-318625-hf7fgtnp 23 4 on on IN cord-318625-hf7fgtnp 23 5 Taxonomy Taxonomy NNP cord-318625-hf7fgtnp 23 6 of of IN cord-318625-hf7fgtnp 23 7 Viruses Viruses NNPS cord-318625-hf7fgtnp 23 8 ( ( -LRB- cord-318625-hf7fgtnp 23 9 ICTV ICTV NNP cord-318625-hf7fgtnp 23 10 ) ) -RRB- cord-318625-hf7fgtnp 23 11 , , , cord-318625-hf7fgtnp 23 12 classified classify VBN cord-318625-hf7fgtnp 23 13 SARS SARS NNP cord-318625-hf7fgtnp 23 14 - - HYPH cord-318625-hf7fgtnp 23 15 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 23 16 under under IN cord-318625-hf7fgtnp 23 17 the the DT cord-318625-hf7fgtnp 23 18 family family NN cord-318625-hf7fgtnp 23 19 Coronaviridae Coronaviridae NNP cord-318625-hf7fgtnp 23 20 of of IN cord-318625-hf7fgtnp 23 21 order order NN cord-318625-hf7fgtnp 23 22 Nidovirales Nidovirales NNP cord-318625-hf7fgtnp 23 23 . . . cord-318625-hf7fgtnp 24 1 The the DT cord-318625-hf7fgtnp 24 2 genomic genomic JJ cord-318625-hf7fgtnp 24 3 sequence sequence NN cord-318625-hf7fgtnp 24 4 of of IN cord-318625-hf7fgtnp 24 5 SARS SARS NNP cord-318625-hf7fgtnp 24 6 - - HYPH cord-318625-hf7fgtnp 24 7 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 24 8 isolated isolate VBN cord-318625-hf7fgtnp 24 9 from from IN cord-318625-hf7fgtnp 24 10 the the DT cord-318625-hf7fgtnp 24 11 bronchoalveolar bronchoalveolar NNP cord-318625-hf7fgtnp 24 12 lavage lavage NN cord-318625-hf7fgtnp 24 13 fluid fluid NN cord-318625-hf7fgtnp 24 14 of of IN cord-318625-hf7fgtnp 24 15 a a DT cord-318625-hf7fgtnp 24 16 patient patient NN cord-318625-hf7fgtnp 24 17 from from IN cord-318625-hf7fgtnp 24 18 Wuhan Wuhan NNP cord-318625-hf7fgtnp 24 19 , , , cord-318625-hf7fgtnp 24 20 China China NNP cord-318625-hf7fgtnp 24 21 showed show VBD cord-318625-hf7fgtnp 24 22 a a DT cord-318625-hf7fgtnp 24 23 length length NN cord-318625-hf7fgtnp 24 24 of of IN cord-318625-hf7fgtnp 24 25 29,903 29,903 CD cord-318625-hf7fgtnp 24 26 nucleotides nucleotide NNS cord-318625-hf7fgtnp 24 27 ( ( -LRB- cord-318625-hf7fgtnp 24 28 GenBank GenBank NNP cord-318625-hf7fgtnp 24 29 accession accession NN cord-318625-hf7fgtnp 24 30 number number NN cord-318625-hf7fgtnp 24 31 NC_045512 NC_045512 NNP cord-318625-hf7fgtnp 24 32 . . . cord-318625-hf7fgtnp 25 1 SARS SARS NNP cord-318625-hf7fgtnp 25 2 - - HYPH cord-318625-hf7fgtnp 25 3 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 25 4 contains contain VBZ cord-318625-hf7fgtnp 25 5 a a DT cord-318625-hf7fgtnp 25 6 positive positive JJ cord-318625-hf7fgtnp 25 7 - - HYPH cord-318625-hf7fgtnp 25 8 sense sense NN cord-318625-hf7fgtnp 25 9 single single JJ cord-318625-hf7fgtnp 25 10 - - HYPH cord-318625-hf7fgtnp 25 11 stranded strand VBN cord-318625-hf7fgtnp 25 12 RNA RNA NNP cord-318625-hf7fgtnp 25 13 with with IN cord-318625-hf7fgtnp 25 14 5ˊ 5ˊ CD cord-318625-hf7fgtnp 25 15 and and CC cord-318625-hf7fgtnp 25 16 3ˊ 3ˊ CD cord-318625-hf7fgtnp 25 17 untranslated untranslated JJ cord-318625-hf7fgtnp 25 18 region region NN cord-318625-hf7fgtnp 25 19 . . . cord-318625-hf7fgtnp 26 1 The the DT cord-318625-hf7fgtnp 26 2 genome genome NN cord-318625-hf7fgtnp 26 3 codes code NNS cord-318625-hf7fgtnp 26 4 for for IN cord-318625-hf7fgtnp 26 5 ORF1a ORF1a NNP cord-318625-hf7fgtnp 26 6 , , , cord-318625-hf7fgtnp 26 7 ORF1b ORF1b NNP cord-318625-hf7fgtnp 26 8 , , , cord-318625-hf7fgtnp 26 9 Spike Spike NNP cord-318625-hf7fgtnp 26 10 ( ( -LRB- cord-318625-hf7fgtnp 26 11 S S NNP cord-318625-hf7fgtnp 26 12 ) ) -RRB- cord-318625-hf7fgtnp 26 13 , , , cord-318625-hf7fgtnp 26 14 ORF3a ORF3a NNP cord-318625-hf7fgtnp 26 15 , , , cord-318625-hf7fgtnp 26 16 ORF3b ORF3b NNP cord-318625-hf7fgtnp 26 17 , , , cord-318625-hf7fgtnp 26 18 Envelope Envelope NNP cord-318625-hf7fgtnp 26 19 ( ( -LRB- cord-318625-hf7fgtnp 26 20 E E NNP cord-318625-hf7fgtnp 26 21 ) ) -RRB- cord-318625-hf7fgtnp 26 22 , , , cord-318625-hf7fgtnp 26 23 Membrane Membrane NNP cord-318625-hf7fgtnp 26 24 ( ( -LRB- cord-318625-hf7fgtnp 26 25 M M NNP cord-318625-hf7fgtnp 26 26 ) ) -RRB- cord-318625-hf7fgtnp 26 27 , , , cord-318625-hf7fgtnp 26 28 ORF6 ORF6 NNP cord-318625-hf7fgtnp 26 29 , , , cord-318625-hf7fgtnp 26 30 ORF7a ORF7a NNP cord-318625-hf7fgtnp 26 31 , , , cord-318625-hf7fgtnp 26 32 ORF7b ORF7b NNP cord-318625-hf7fgtnp 26 33 , , , cord-318625-hf7fgtnp 26 34 ORF8 ORF8 NNP cord-318625-hf7fgtnp 26 35 , , , cord-318625-hf7fgtnp 26 36 ORF9b ORF9b NNP cord-318625-hf7fgtnp 26 37 , , , cord-318625-hf7fgtnp 26 38 ORF14 ORF14 NNP cord-318625-hf7fgtnp 26 39 , , , cord-318625-hf7fgtnp 26 40 Nucleocapsid Nucleocapsid NNP cord-318625-hf7fgtnp 26 41 ( ( -LRB- cord-318625-hf7fgtnp 26 42 N N NNP cord-318625-hf7fgtnp 26 43 ) ) -RRB- cord-318625-hf7fgtnp 26 44 , , , cord-318625-hf7fgtnp 26 45 and and CC cord-318625-hf7fgtnp 26 46 ORF10 ORF10 NNP cord-318625-hf7fgtnp 26 47 from from IN cord-318625-hf7fgtnp 26 48 5ˊ 5ˊ CD cord-318625-hf7fgtnp 26 49 to to IN cord-318625-hf7fgtnp 26 50 3ˊ 3ˊ CD cord-318625-hf7fgtnp 26 51 Zhu Zhu NNP cord-318625-hf7fgtnp 26 52 et et FW cord-318625-hf7fgtnp 26 53 al al NNP cord-318625-hf7fgtnp 26 54 . . NNP cord-318625-hf7fgtnp 26 55 , , , cord-318625-hf7fgtnp 26 56 2020 2020 CD cord-318625-hf7fgtnp 26 57 ) ) -RRB- cord-318625-hf7fgtnp 26 58 . . . cord-318625-hf7fgtnp 27 1 The the DT cord-318625-hf7fgtnp 27 2 S S NNP cord-318625-hf7fgtnp 27 3 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 27 4 forms form VBZ cord-318625-hf7fgtnp 27 5 a a DT cord-318625-hf7fgtnp 27 6 homotrimer homotrimer NN cord-318625-hf7fgtnp 27 7 and and CC cord-318625-hf7fgtnp 27 8 mediates mediate VBZ cord-318625-hf7fgtnp 27 9 viral viral JJ cord-318625-hf7fgtnp 27 10 entry entry NN cord-318625-hf7fgtnp 27 11 into into IN cord-318625-hf7fgtnp 27 12 host host NN cord-318625-hf7fgtnp 27 13 cells cell NNS cord-318625-hf7fgtnp 27 14 . . . cord-318625-hf7fgtnp 28 1 The the DT cord-318625-hf7fgtnp 28 2 S S NNP cord-318625-hf7fgtnp 28 3 protein protein NN cord-318625-hf7fgtnp 28 4 is be VBZ cord-318625-hf7fgtnp 28 5 a a DT cord-318625-hf7fgtnp 28 6 potential potential JJ cord-318625-hf7fgtnp 28 7 target target NN cord-318625-hf7fgtnp 28 8 for for IN cord-318625-hf7fgtnp 28 9 therapeutic therapeutic JJ cord-318625-hf7fgtnp 28 10 and and CC cord-318625-hf7fgtnp 28 11 vaccine vaccine NN cord-318625-hf7fgtnp 28 12 design design NN cord-318625-hf7fgtnp 28 13 against against IN cord-318625-hf7fgtnp 28 14 SARS SARS NNP cord-318625-hf7fgtnp 28 15 - - HYPH cord-318625-hf7fgtnp 28 16 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 28 17 infection infection NN cord-318625-hf7fgtnp 28 18 in in IN cord-318625-hf7fgtnp 28 19 humans human NNS cord-318625-hf7fgtnp 29 1 ( ( -LRB- cord-318625-hf7fgtnp 29 2 Li Li NNP cord-318625-hf7fgtnp 29 3 , , , cord-318625-hf7fgtnp 29 4 2016 2016 CD cord-318625-hf7fgtnp 29 5 ; ; . cord-318625-hf7fgtnp 30 1 Tortorici Tortorici NNP cord-318625-hf7fgtnp 30 2 et et NNP cord-318625-hf7fgtnp 30 3 al al NNP cord-318625-hf7fgtnp 30 4 . . NNP cord-318625-hf7fgtnp 30 5 , , , cord-318625-hf7fgtnp 30 6 2019 2019 CD cord-318625-hf7fgtnp 30 7 ) ) -RRB- cord-318625-hf7fgtnp 30 8 . . . cord-318625-hf7fgtnp 31 1 The the DT cord-318625-hf7fgtnp 31 2 S S NNP cord-318625-hf7fgtnp 31 3 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 31 4 comprises comprise VBZ cord-318625-hf7fgtnp 31 5 two two CD cord-318625-hf7fgtnp 31 6 functional functional JJ cord-318625-hf7fgtnp 31 7 subunits subunit NNS cord-318625-hf7fgtnp 31 8 : : : cord-318625-hf7fgtnp 31 9 the the DT cord-318625-hf7fgtnp 31 10 S1 S1 NNP cord-318625-hf7fgtnp 31 11 subunit subunit NN cord-318625-hf7fgtnp 31 12 is be VBZ cord-318625-hf7fgtnp 31 13 responsible responsible JJ cord-318625-hf7fgtnp 31 14 for for IN cord-318625-hf7fgtnp 31 15 binding bind VBG cord-318625-hf7fgtnp 31 16 to to IN cord-318625-hf7fgtnp 31 17 the the DT cord-318625-hf7fgtnp 31 18 host host NN cord-318625-hf7fgtnp 31 19 cell cell NN cord-318625-hf7fgtnp 31 20 receptor receptor NN cord-318625-hf7fgtnp 31 21 and and CC cord-318625-hf7fgtnp 31 22 the the DT cord-318625-hf7fgtnp 31 23 S2 S2 NNP cord-318625-hf7fgtnp 31 24 subunit subunit NN cord-318625-hf7fgtnp 31 25 is be VBZ cord-318625-hf7fgtnp 31 26 responsible responsible JJ cord-318625-hf7fgtnp 31 27 for for IN cord-318625-hf7fgtnp 31 28 fusion fusion NN cord-318625-hf7fgtnp 31 29 of of IN cord-318625-hf7fgtnp 31 30 the the DT cord-318625-hf7fgtnp 31 31 virus virus NN cord-318625-hf7fgtnp 31 32 with with IN cord-318625-hf7fgtnp 31 33 the the DT cord-318625-hf7fgtnp 31 34 cell cell NN cord-318625-hf7fgtnp 31 35 membrane membrane NN cord-318625-hf7fgtnp 31 36 . . . cord-318625-hf7fgtnp 32 1 Usually usually RB cord-318625-hf7fgtnp 32 2 in in IN cord-318625-hf7fgtnp 32 3 CoVs CoVs NNP cord-318625-hf7fgtnp 32 4 , , , cord-318625-hf7fgtnp 32 5 S S NNP cord-318625-hf7fgtnp 32 6 is be VBZ cord-318625-hf7fgtnp 32 7 cleaved cleave VBN cord-318625-hf7fgtnp 32 8 at at IN cord-318625-hf7fgtnp 32 9 the the DT cord-318625-hf7fgtnp 32 10 boundary boundary NN cord-318625-hf7fgtnp 32 11 between between IN cord-318625-hf7fgtnp 32 12 S1 S1 NNP cord-318625-hf7fgtnp 32 13 and and CC cord-318625-hf7fgtnp 32 14 S2 S2 NNP cord-318625-hf7fgtnp 32 15 subunits subunit NNS cord-318625-hf7fgtnp 32 16 , , , cord-318625-hf7fgtnp 32 17 which which WDT cord-318625-hf7fgtnp 32 18 remain remain VBP cord-318625-hf7fgtnp 32 19 non non JJ cord-318625-hf7fgtnp 32 20 - - JJ cord-318625-hf7fgtnp 32 21 covalently covalently RB cord-318625-hf7fgtnp 32 22 bound bind VBN cord-318625-hf7fgtnp 32 23 in in IN cord-318625-hf7fgtnp 32 24 the the DT cord-318625-hf7fgtnp 32 25 prefusion prefusion NN cord-318625-hf7fgtnp 32 26 conformation conformation NN cord-318625-hf7fgtnp 32 27 , , , cord-318625-hf7fgtnp 32 28 to to TO cord-318625-hf7fgtnp 32 29 activate activate VB cord-318625-hf7fgtnp 32 30 the the DT cord-318625-hf7fgtnp 32 31 protein protein NN cord-318625-hf7fgtnp 32 32 for for IN cord-318625-hf7fgtnp 32 33 membrane membrane NN cord-318625-hf7fgtnp 32 34 fusion fusion NN cord-318625-hf7fgtnp 32 35 via via IN cord-318625-hf7fgtnp 32 36 extensive extensive JJ cord-318625-hf7fgtnp 32 37 irreversible irreversible JJ cord-318625-hf7fgtnp 32 38 conformational conformational JJ cord-318625-hf7fgtnp 32 39 changes change NNS cord-318625-hf7fgtnp 32 40 ( ( -LRB- cord-318625-hf7fgtnp 32 41 Burkard Burkard NNP cord-318625-hf7fgtnp 32 42 et et NNP cord-318625-hf7fgtnp 32 43 al al NNP cord-318625-hf7fgtnp 32 44 . . NNP cord-318625-hf7fgtnp 32 45 , , , cord-318625-hf7fgtnp 32 46 2014 2014 CD cord-318625-hf7fgtnp 32 47 ; ; : cord-318625-hf7fgtnp 32 48 Park Park NNP cord-318625-hf7fgtnp 32 49 et et FW cord-318625-hf7fgtnp 32 50 al al NNP cord-318625-hf7fgtnp 32 51 . . NNP cord-318625-hf7fgtnp 32 52 , , , cord-318625-hf7fgtnp 32 53 2016 2016 CD cord-318625-hf7fgtnp 32 54 ; ; : cord-318625-hf7fgtnp 32 55 Walls Walls NNPS cord-318625-hf7fgtnp 32 56 et et NNP cord-318625-hf7fgtnp 32 57 al al NNP cord-318625-hf7fgtnp 32 58 . . NNP cord-318625-hf7fgtnp 32 59 , , , cord-318625-hf7fgtnp 32 60 2017 2017 CD cord-318625-hf7fgtnp 32 61 ) ) -RRB- cord-318625-hf7fgtnp 32 62 . . . cord-318625-hf7fgtnp 33 1 Setting set VBG cord-318625-hf7fgtnp 33 2 it -PRON- PRP cord-318625-hf7fgtnp 33 3 apart apart RB cord-318625-hf7fgtnp 33 4 from from IN cord-318625-hf7fgtnp 33 5 other other JJ cord-318625-hf7fgtnp 33 6 SARS SARS NNP cord-318625-hf7fgtnp 33 7 - - HYPH cord-318625-hf7fgtnp 33 8 CoVs CoVs NNP cord-318625-hf7fgtnp 33 9 , , , cord-318625-hf7fgtnp 33 10 it -PRON- PRP cord-318625-hf7fgtnp 33 11 is be VBZ cord-318625-hf7fgtnp 33 12 found find VBN cord-318625-hf7fgtnp 33 13 that that IN cord-318625-hf7fgtnp 33 14 the the DT cord-318625-hf7fgtnp 33 15 S S NNP cord-318625-hf7fgtnp 33 16 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 33 17 of of IN cord-318625-hf7fgtnp 33 18 SARS SARS NNP cord-318625-hf7fgtnp 33 19 - - HYPH cord-318625-hf7fgtnp 33 20 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 33 21 harbors harbor VBZ cord-318625-hf7fgtnp 33 22 a a DT cord-318625-hf7fgtnp 33 23 J J NNP cord-318625-hf7fgtnp 33 24 o o NN cord-318625-hf7fgtnp 33 25 u u NN cord-318625-hf7fgtnp 33 26 r r NN cord-318625-hf7fgtnp 33 27 n n NN cord-318625-hf7fgtnp 33 28 a a DT cord-318625-hf7fgtnp 33 29 l l NN cord-318625-hf7fgtnp 33 30 P p NN cord-318625-hf7fgtnp 33 31 r r NN cord-318625-hf7fgtnp 33 32 e e NN cord-318625-hf7fgtnp 33 33 -p -p NN cord-318625-hf7fgtnp 34 1 r r NN cord-318625-hf7fgtnp 34 2 o o NN cord-318625-hf7fgtnp 34 3 o o NN cord-318625-hf7fgtnp 34 4 f f NN cord-318625-hf7fgtnp 34 5 furin furin NN cord-318625-hf7fgtnp 34 6 cleavage cleavage NN cord-318625-hf7fgtnp 34 7 site site NN cord-318625-hf7fgtnp 34 8 at at IN cord-318625-hf7fgtnp 34 9 the the DT cord-318625-hf7fgtnp 34 10 boundary boundary NN cord-318625-hf7fgtnp 34 11 between between IN cord-318625-hf7fgtnp 34 12 the the DT cord-318625-hf7fgtnp 34 13 S1 S1 NNP cord-318625-hf7fgtnp 34 14 / / SYM cord-318625-hf7fgtnp 34 15 S2 s2 NN cord-318625-hf7fgtnp 34 16 subunits subunit NNS cord-318625-hf7fgtnp 34 17 ( ( -LRB- cord-318625-hf7fgtnp 34 18 Walls Walls NNPS cord-318625-hf7fgtnp 34 19 et et NNP cord-318625-hf7fgtnp 34 20 al al NNP cord-318625-hf7fgtnp 34 21 . . NNP cord-318625-hf7fgtnp 34 22 , , , cord-318625-hf7fgtnp 34 23 2020 2020 CD cord-318625-hf7fgtnp 34 24 ) ) -RRB- cord-318625-hf7fgtnp 34 25 . . . cord-318625-hf7fgtnp 35 1 By by IN cord-318625-hf7fgtnp 35 2 now now RB cord-318625-hf7fgtnp 35 3 , , , cord-318625-hf7fgtnp 35 4 it -PRON- PRP cord-318625-hf7fgtnp 35 5 is be VBZ cord-318625-hf7fgtnp 35 6 evident evident JJ cord-318625-hf7fgtnp 35 7 that that IN cord-318625-hf7fgtnp 35 8 SARS SARS NNP cord-318625-hf7fgtnp 35 9 - - HYPH cord-318625-hf7fgtnp 35 10 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 35 11 S S NNP cord-318625-hf7fgtnp 35 12 uses use VBZ cord-318625-hf7fgtnp 35 13 angiotensin angiotensin NN cord-318625-hf7fgtnp 35 14 - - HYPH cord-318625-hf7fgtnp 35 15 converting convert VBG cord-318625-hf7fgtnp 35 16 enzyme enzyme NN cord-318625-hf7fgtnp 35 17 2 2 CD cord-318625-hf7fgtnp 35 18 ( ( -LRB- cord-318625-hf7fgtnp 35 19 ACE2 ACE2 NNP cord-318625-hf7fgtnp 35 20 ) ) -RRB- cord-318625-hf7fgtnp 36 1 receptormediated receptormediate VBN cord-318625-hf7fgtnp 36 2 entry entry NN cord-318625-hf7fgtnp 36 3 into into IN cord-318625-hf7fgtnp 36 4 cells cell NNS cord-318625-hf7fgtnp 36 5 . . . cord-318625-hf7fgtnp 37 1 Some some DT cord-318625-hf7fgtnp 37 2 studies study NNS cord-318625-hf7fgtnp 37 3 suggest suggest VBP cord-318625-hf7fgtnp 37 4 similar similar JJ cord-318625-hf7fgtnp 37 5 binding binding JJ cord-318625-hf7fgtnp 37 6 affinities affinity NNS cord-318625-hf7fgtnp 37 7 to to IN cord-318625-hf7fgtnp 37 8 human human JJ cord-318625-hf7fgtnp 37 9 ACE2 ACE2 NNP cord-318625-hf7fgtnp 37 10 with with IN cord-318625-hf7fgtnp 37 11 the the DT cord-318625-hf7fgtnp 37 12 S S NNP cord-318625-hf7fgtnp 37 13 protein protein NN cord-318625-hf7fgtnp 37 14 of of IN cord-318625-hf7fgtnp 37 15 SARS SARS NNP cord-318625-hf7fgtnp 37 16 - - HYPH cord-318625-hf7fgtnp 37 17 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 37 18 and and CC cord-318625-hf7fgtnp 37 19 SARS SARS NNP cord-318625-hf7fgtnp 37 20 - - HYPH cord-318625-hf7fgtnp 37 21 CoV CoV NNP cord-318625-hf7fgtnp 37 22 ( ( -LRB- cord-318625-hf7fgtnp 37 23 Letko Letko NNP cord-318625-hf7fgtnp 37 24 et et NNP cord-318625-hf7fgtnp 37 25 al al NNP cord-318625-hf7fgtnp 37 26 . . NNP cord-318625-hf7fgtnp 37 27 , , , cord-318625-hf7fgtnp 37 28 2020 2020 CD cord-318625-hf7fgtnp 37 29 ; ; : cord-318625-hf7fgtnp 37 30 Walls Walls NNPS cord-318625-hf7fgtnp 37 31 et et NNP cord-318625-hf7fgtnp 37 32 al al NNP cord-318625-hf7fgtnp 37 33 . . NNP cord-318625-hf7fgtnp 37 34 , , , cord-318625-hf7fgtnp 37 35 2020 2020 CD cord-318625-hf7fgtnp 37 36 ) ) -RRB- cord-318625-hf7fgtnp 37 37 . . . cord-318625-hf7fgtnp 38 1 However however RB cord-318625-hf7fgtnp 38 2 , , , cord-318625-hf7fgtnp 38 3 some some DT cord-318625-hf7fgtnp 38 4 suggest suggest VBP cord-318625-hf7fgtnp 38 5 that that IN cord-318625-hf7fgtnp 38 6 SARS SARS NNP cord-318625-hf7fgtnp 38 7 - - HYPH cord-318625-hf7fgtnp 38 8 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 38 9 binds bind VBZ cord-318625-hf7fgtnp 38 10 ACE2 ACE2 NNP cord-318625-hf7fgtnp 38 11 with with IN cord-318625-hf7fgtnp 38 12 higher high JJR cord-318625-hf7fgtnp 38 13 affinity affinity NN cord-318625-hf7fgtnp 38 14 than than IN cord-318625-hf7fgtnp 38 15 SARS SARS NNP cord-318625-hf7fgtnp 38 16 - - HYPH cord-318625-hf7fgtnp 38 17 CoV CoV NNP cord-318625-hf7fgtnp 38 18 ( ( -LRB- cord-318625-hf7fgtnp 38 19 Tai Tai NNP cord-318625-hf7fgtnp 38 20 et et NNP cord-318625-hf7fgtnp 38 21 al al NNP cord-318625-hf7fgtnp 38 22 . . NNP cord-318625-hf7fgtnp 38 23 , , , cord-318625-hf7fgtnp 38 24 2020 2020 CD cord-318625-hf7fgtnp 38 25 ; ; . cord-318625-hf7fgtnp 39 1 Wang Wang NNP cord-318625-hf7fgtnp 39 2 et et NNP cord-318625-hf7fgtnp 39 3 al al NNP cord-318625-hf7fgtnp 39 4 . . NNP cord-318625-hf7fgtnp 39 5 , , , cord-318625-hf7fgtnp 39 6 2020 2020 CD cord-318625-hf7fgtnp 39 7 ; ; . cord-318625-hf7fgtnp 40 1 Wrapp Wrapp NNP cord-318625-hf7fgtnp 40 2 et et NNP cord-318625-hf7fgtnp 40 3 al al NNP cord-318625-hf7fgtnp 40 4 . . NNP cord-318625-hf7fgtnp 40 5 , , , cord-318625-hf7fgtnp 40 6 2020 2020 CD cord-318625-hf7fgtnp 40 7 ) ) -RRB- cord-318625-hf7fgtnp 40 8 . . . cord-318625-hf7fgtnp 41 1 As as IN cord-318625-hf7fgtnp 41 2 the the DT cord-318625-hf7fgtnp 41 3 situation situation NN cord-318625-hf7fgtnp 41 4 worsens worsen VBZ cord-318625-hf7fgtnp 41 5 , , , cord-318625-hf7fgtnp 41 6 there there EX cord-318625-hf7fgtnp 41 7 is be VBZ cord-318625-hf7fgtnp 41 8 a a DT cord-318625-hf7fgtnp 41 9 growing grow VBG cord-318625-hf7fgtnp 41 10 need need NN cord-318625-hf7fgtnp 41 11 for for IN cord-318625-hf7fgtnp 41 12 the the DT cord-318625-hf7fgtnp 41 13 development development NN cord-318625-hf7fgtnp 41 14 of of IN cord-318625-hf7fgtnp 41 15 suitable suitable JJ cord-318625-hf7fgtnp 41 16 therapeutics therapeutic NNS cord-318625-hf7fgtnp 41 17 , , , cord-318625-hf7fgtnp 41 18 vaccines vaccine NNS cord-318625-hf7fgtnp 41 19 , , , cord-318625-hf7fgtnp 41 20 and and CC cord-318625-hf7fgtnp 41 21 other other JJ cord-318625-hf7fgtnp 41 22 diagnostics diagnostic NNS cord-318625-hf7fgtnp 41 23 against against IN cord-318625-hf7fgtnp 41 24 SARS SARS NNP cord-318625-hf7fgtnp 41 25 - - HYPH cord-318625-hf7fgtnp 41 26 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 41 27 for for IN cord-318625-hf7fgtnp 41 28 effective effective JJ cord-318625-hf7fgtnp 41 29 disease disease NN cord-318625-hf7fgtnp 41 30 management management NN cord-318625-hf7fgtnp 41 31 strategies strategy NNS cord-318625-hf7fgtnp 41 32 . . . cord-318625-hf7fgtnp 42 1 Vaccines vaccine NNS cord-318625-hf7fgtnp 42 2 and and CC cord-318625-hf7fgtnp 42 3 diagnostic diagnostic JJ cord-318625-hf7fgtnp 42 4 assays assay NNS cord-318625-hf7fgtnp 42 5 based base VBN cord-318625-hf7fgtnp 42 6 on on IN cord-318625-hf7fgtnp 42 7 peptides peptide NNS cord-318625-hf7fgtnp 42 8 have have VBP cord-318625-hf7fgtnp 42 9 become become VBN cord-318625-hf7fgtnp 42 10 increasingly increasingly RB cord-318625-hf7fgtnp 42 11 substantial substantial JJ cord-318625-hf7fgtnp 42 12 and and CC cord-318625-hf7fgtnp 42 13 indispensable indispensable JJ cord-318625-hf7fgtnp 42 14 for for IN cord-318625-hf7fgtnp 42 15 their -PRON- PRP$ cord-318625-hf7fgtnp 42 16 advantages advantage NNS cord-318625-hf7fgtnp 42 17 over over IN cord-318625-hf7fgtnp 42 18 conventional conventional JJ cord-318625-hf7fgtnp 42 19 methods method NNS cord-318625-hf7fgtnp 42 20 ( ( -LRB- cord-318625-hf7fgtnp 42 21 Li Li NNP cord-318625-hf7fgtnp 42 22 et et NNP cord-318625-hf7fgtnp 42 23 al al NNP cord-318625-hf7fgtnp 42 24 . . NNP cord-318625-hf7fgtnp 42 25 , , , cord-318625-hf7fgtnp 42 26 2014 2014 CD cord-318625-hf7fgtnp 42 27 ; ; : cord-318625-hf7fgtnp 42 28 Mohanraj Mohanraj NNP cord-318625-hf7fgtnp 42 29 et et NNP cord-318625-hf7fgtnp 42 30 al al NNP cord-318625-hf7fgtnp 42 31 . . NNP cord-318625-hf7fgtnp 42 32 , , , cord-318625-hf7fgtnp 42 33 2017 2017 CD cord-318625-hf7fgtnp 42 34 ) ) -RRB- cord-318625-hf7fgtnp 42 35 . . . cord-318625-hf7fgtnp 43 1 The the DT cord-318625-hf7fgtnp 43 2 present present JJ cord-318625-hf7fgtnp 43 3 study study NN cord-318625-hf7fgtnp 43 4 aimed aim VBN cord-318625-hf7fgtnp 43 5 to to TO cord-318625-hf7fgtnp 43 6 locate locate VB cord-318625-hf7fgtnp 43 7 appropriate appropriate JJ cord-318625-hf7fgtnp 43 8 epitopes epitope NNS cord-318625-hf7fgtnp 43 9 within within IN cord-318625-hf7fgtnp 43 10 a a DT cord-318625-hf7fgtnp 43 11 particular particular JJ cord-318625-hf7fgtnp 43 12 protein protein NN cord-318625-hf7fgtnp 43 13 antigen antigen NN cord-318625-hf7fgtnp 43 14 that that WDT cord-318625-hf7fgtnp 43 15 can can MD cord-318625-hf7fgtnp 43 16 elicit elicit VB cord-318625-hf7fgtnp 43 17 an an DT cord-318625-hf7fgtnp 43 18 immune immune JJ cord-318625-hf7fgtnp 43 19 response response NN cord-318625-hf7fgtnp 43 20 and and CC cord-318625-hf7fgtnp 43 21 could could MD cord-318625-hf7fgtnp 43 22 be be VB cord-318625-hf7fgtnp 43 23 selected select VBN cord-318625-hf7fgtnp 43 24 for for IN cord-318625-hf7fgtnp 43 25 the the DT cord-318625-hf7fgtnp 43 26 synthesis synthesis NN cord-318625-hf7fgtnp 43 27 of of IN cord-318625-hf7fgtnp 43 28 an an DT cord-318625-hf7fgtnp 43 29 immunogenic immunogenic JJ cord-318625-hf7fgtnp 43 30 peptide peptide NN cord-318625-hf7fgtnp 43 31 . . . cord-318625-hf7fgtnp 44 1 Using use VBG cord-318625-hf7fgtnp 44 2 a a DT cord-318625-hf7fgtnp 44 3 computational computational JJ cord-318625-hf7fgtnp 44 4 approach approach NN cord-318625-hf7fgtnp 44 5 , , , cord-318625-hf7fgtnp 44 6 the the DT cord-318625-hf7fgtnp 44 7 S S NNP cord-318625-hf7fgtnp 44 8 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 44 9 of of IN cord-318625-hf7fgtnp 44 10 SARS SARS NNP cord-318625-hf7fgtnp 44 11 - - HYPH cord-318625-hf7fgtnp 44 12 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 44 13 was be VBD cord-318625-hf7fgtnp 44 14 explored explore VBN cord-318625-hf7fgtnp 44 15 to to TO cord-318625-hf7fgtnp 44 16 identify identify VB cord-318625-hf7fgtnp 44 17 various various JJ cord-318625-hf7fgtnp 44 18 immunodominant immunodominant JJ cord-318625-hf7fgtnp 44 19 epitopes epitope NNS cord-318625-hf7fgtnp 44 20 for for IN cord-318625-hf7fgtnp 44 21 the the DT cord-318625-hf7fgtnp 44 22 development development NN cord-318625-hf7fgtnp 44 23 of of IN cord-318625-hf7fgtnp 44 24 diagnostics diagnostic NNS cord-318625-hf7fgtnp 44 25 and and CC cord-318625-hf7fgtnp 44 26 vaccines vaccine NNS cord-318625-hf7fgtnp 44 27 . . . cord-318625-hf7fgtnp 45 1 Besides besides RB cord-318625-hf7fgtnp 45 2 , , , cord-318625-hf7fgtnp 45 3 the the DT cord-318625-hf7fgtnp 45 4 results result NNS cord-318625-hf7fgtnp 45 5 could could MD cord-318625-hf7fgtnp 45 6 also also RB cord-318625-hf7fgtnp 45 7 help help VB cord-318625-hf7fgtnp 45 8 us -PRON- PRP cord-318625-hf7fgtnp 45 9 to to TO cord-318625-hf7fgtnp 45 10 understand understand VB cord-318625-hf7fgtnp 45 11 the the DT cord-318625-hf7fgtnp 45 12 SARS SARS NNP cord-318625-hf7fgtnp 45 13 - - HYPH cord-318625-hf7fgtnp 45 14 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 45 15 surface surface NN cord-318625-hf7fgtnp 45 16 protein protein NN cord-318625-hf7fgtnp 45 17 response response NN cord-318625-hf7fgtnp 45 18 towards towards IN cord-318625-hf7fgtnp 45 19 T T NNP cord-318625-hf7fgtnp 45 20 - - HYPH cord-318625-hf7fgtnp 45 21 and and CC cord-318625-hf7fgtnp 45 22 B b NN cord-318625-hf7fgtnp 45 23 - - HYPH cord-318625-hf7fgtnp 45 24 cells cell NNS cord-318625-hf7fgtnp 45 25 . . . cord-318625-hf7fgtnp 46 1 The the DT cord-318625-hf7fgtnp 46 2 amino amino NN cord-318625-hf7fgtnp 46 3 acid acid NN cord-318625-hf7fgtnp 46 4 sequences sequence NNS cord-318625-hf7fgtnp 46 5 ( ( -LRB- cord-318625-hf7fgtnp 46 6 n=98 n=98 NNP cord-318625-hf7fgtnp 46 7 ) ) -RRB- cord-318625-hf7fgtnp 46 8 of of IN cord-318625-hf7fgtnp 46 9 S S NNP cord-318625-hf7fgtnp 46 10 protein protein NN cord-318625-hf7fgtnp 46 11 available available JJ cord-318625-hf7fgtnp 46 12 at at IN cord-318625-hf7fgtnp 46 13 the the DT cord-318625-hf7fgtnp 46 14 time time NN cord-318625-hf7fgtnp 46 15 of of IN cord-318625-hf7fgtnp 46 16 study study NN cord-318625-hf7fgtnp 46 17 on on IN cord-318625-hf7fgtnp 46 18 targeted target VBN cord-318625-hf7fgtnp 46 19 SARS SARS NNP cord-318625-hf7fgtnp 46 20 - - HYPH cord-318625-hf7fgtnp 46 21 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 46 22 were be VBD cord-318625-hf7fgtnp 46 23 downloaded download VBN cord-318625-hf7fgtnp 46 24 from from IN cord-318625-hf7fgtnp 46 25 the the DT cord-318625-hf7fgtnp 46 26 National National NNP cord-318625-hf7fgtnp 46 27 Centre Centre NNP cord-318625-hf7fgtnp 46 28 for for IN cord-318625-hf7fgtnp 46 29 Biotechnological Biotechnological NNP cord-318625-hf7fgtnp 46 30 Information Information NNP cord-318625-hf7fgtnp 46 31 ( ( -LRB- cord-318625-hf7fgtnp 46 32 NCBI NCBI NNP cord-318625-hf7fgtnp 46 33 ) ) -RRB- cord-318625-hf7fgtnp 46 34 database database NN cord-318625-hf7fgtnp 46 35 . . . cord-318625-hf7fgtnp 47 1 To to TO cord-318625-hf7fgtnp 47 2 identify identify VB cord-318625-hf7fgtnp 47 3 an an DT cord-318625-hf7fgtnp 47 4 immunodominant immunodominant JJ cord-318625-hf7fgtnp 47 5 region region NN cord-318625-hf7fgtnp 47 6 , , , cord-318625-hf7fgtnp 47 7 it -PRON- PRP cord-318625-hf7fgtnp 47 8 is be VBZ cord-318625-hf7fgtnp 47 9 of of IN cord-318625-hf7fgtnp 47 10 extreme extreme JJ cord-318625-hf7fgtnp 47 11 importance importance NN cord-318625-hf7fgtnp 47 12 to to TO cord-318625-hf7fgtnp 47 13 select select VB cord-318625-hf7fgtnp 47 14 the the DT cord-318625-hf7fgtnp 47 15 conserved conserve VBN cord-318625-hf7fgtnp 47 16 region region NN cord-318625-hf7fgtnp 47 17 within within IN cord-318625-hf7fgtnp 47 18 the the DT cord-318625-hf7fgtnp 47 19 S S NNP cord-318625-hf7fgtnp 47 20 protein protein NN cord-318625-hf7fgtnp 47 21 of of IN cord-318625-hf7fgtnp 47 22 SARS SARS NNP cord-318625-hf7fgtnp 47 23 - - HYPH cord-318625-hf7fgtnp 47 24 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 47 25 . . . cord-318625-hf7fgtnp 48 1 All all PDT cord-318625-hf7fgtnp 48 2 the the DT cord-318625-hf7fgtnp 48 3 sequences sequence NNS cord-318625-hf7fgtnp 48 4 were be VBD cord-318625-hf7fgtnp 48 5 compared compare VBN cord-318625-hf7fgtnp 48 6 J J NNP cord-318625-hf7fgtnp 48 7 o o NN cord-318625-hf7fgtnp 48 8 u u NN cord-318625-hf7fgtnp 48 9 r r NN cord-318625-hf7fgtnp 48 10 n n NN cord-318625-hf7fgtnp 48 11 a a DT cord-318625-hf7fgtnp 48 12 l l NN cord-318625-hf7fgtnp 48 13 P p NN cord-318625-hf7fgtnp 48 14 r r NN cord-318625-hf7fgtnp 48 15 e e NN cord-318625-hf7fgtnp 48 16 -p -p NN cord-318625-hf7fgtnp 49 1 r r NN cord-318625-hf7fgtnp 49 2 o o NN cord-318625-hf7fgtnp 49 3 o o NN cord-318625-hf7fgtnp 49 4 f f NN cord-318625-hf7fgtnp 49 5 among among IN cord-318625-hf7fgtnp 49 6 themselves -PRON- PRP cord-318625-hf7fgtnp 49 7 for for IN cord-318625-hf7fgtnp 49 8 variability variability NN cord-318625-hf7fgtnp 49 9 using use VBG cord-318625-hf7fgtnp 49 10 the the DT cord-318625-hf7fgtnp 49 11 protein protein NN cord-318625-hf7fgtnp 49 12 variability variability NN cord-318625-hf7fgtnp 49 13 server server NN cord-318625-hf7fgtnp 49 14 by by IN cord-318625-hf7fgtnp 49 15 the the DT cord-318625-hf7fgtnp 49 16 Shannon Shannon NNP cord-318625-hf7fgtnp 49 17 method method NN cord-318625-hf7fgtnp 49 18 ( ( -LRB- cord-318625-hf7fgtnp 49 19 Garcia Garcia NNP cord-318625-hf7fgtnp 49 20 - - HYPH cord-318625-hf7fgtnp 49 21 Boronat Boronat NNP cord-318625-hf7fgtnp 49 22 et et NNP cord-318625-hf7fgtnp 49 23 al al NNP cord-318625-hf7fgtnp 49 24 . . NNP cord-318625-hf7fgtnp 49 25 , , , cord-318625-hf7fgtnp 49 26 2008 2008 CD cord-318625-hf7fgtnp 49 27 ) ) -RRB- cord-318625-hf7fgtnp 49 28 . . . cord-318625-hf7fgtnp 50 1 The the DT cord-318625-hf7fgtnp 50 2 average average JJ cord-318625-hf7fgtnp 50 3 solvent solvent NN cord-318625-hf7fgtnp 50 4 accessibility accessibility NN cord-318625-hf7fgtnp 50 5 ( ( -LRB- cord-318625-hf7fgtnp 50 6 ASA ASA NNP cord-318625-hf7fgtnp 50 7 ) ) -RRB- cord-318625-hf7fgtnp 50 8 profile profile NN cord-318625-hf7fgtnp 50 9 was be VBD cord-318625-hf7fgtnp 50 10 predicted predict VBN cord-318625-hf7fgtnp 50 11 for for IN cord-318625-hf7fgtnp 50 12 each each DT cord-318625-hf7fgtnp 50 13 sequence sequence NN cord-318625-hf7fgtnp 50 14 using use VBG cord-318625-hf7fgtnp 50 15 the the DT cord-318625-hf7fgtnp 50 16 SABLE SABLE NNP cord-318625-hf7fgtnp 50 17 server server NN cord-318625-hf7fgtnp 50 18 ( ( -LRB- cord-318625-hf7fgtnp 50 19 Adamczak Adamczak NNP cord-318625-hf7fgtnp 50 20 et et NNP cord-318625-hf7fgtnp 50 21 al al NNP cord-318625-hf7fgtnp 50 22 . . NNP cord-318625-hf7fgtnp 50 23 , , , cord-318625-hf7fgtnp 50 24 2004 2004 CD cord-318625-hf7fgtnp 50 25 ) ) -RRB- cord-318625-hf7fgtnp 50 26 . . . cord-318625-hf7fgtnp 51 1 BepiPred BepiPred NNP cord-318625-hf7fgtnp 51 2 1.0 1.0 CD cord-318625-hf7fgtnp 52 1 Linear Linear NNP cord-318625-hf7fgtnp 52 2 Epitope Epitope NNP cord-318625-hf7fgtnp 52 3 Prediction Prediction NNP cord-318625-hf7fgtnp 52 4 module module NN cord-318625-hf7fgtnp 52 5 incorporated incorporate VBN cord-318625-hf7fgtnp 52 6 in in IN cord-318625-hf7fgtnp 52 7 Immune Immune NNP cord-318625-hf7fgtnp 52 8 Epitope Epitope NNP cord-318625-hf7fgtnp 52 9 Database Database NNP cord-318625-hf7fgtnp 52 10 ( ( -LRB- cord-318625-hf7fgtnp 52 11 IEDB IEDB NNP cord-318625-hf7fgtnp 52 12 ) ) -RRB- cord-318625-hf7fgtnp 52 13 was be VBD cord-318625-hf7fgtnp 52 14 used use VBN cord-318625-hf7fgtnp 52 15 to to TO cord-318625-hf7fgtnp 52 16 predict predict VB cord-318625-hf7fgtnp 52 17 potential potential JJ cord-318625-hf7fgtnp 52 18 epitopes epitope NNS cord-318625-hf7fgtnp 52 19 within within IN cord-318625-hf7fgtnp 52 20 the the DT cord-318625-hf7fgtnp 52 21 S S NNP cord-318625-hf7fgtnp 52 22 protein protein NN cord-318625-hf7fgtnp 52 23 ( ( -LRB- cord-318625-hf7fgtnp 52 24 Haste Haste NNP cord-318625-hf7fgtnp 52 25 Andersen Andersen NNP cord-318625-hf7fgtnp 52 26 et et NNP cord-318625-hf7fgtnp 52 27 al al NNP cord-318625-hf7fgtnp 52 28 . . NNP cord-318625-hf7fgtnp 52 29 , , , cord-318625-hf7fgtnp 52 30 2006 2006 CD cord-318625-hf7fgtnp 52 31 ; ; : cord-318625-hf7fgtnp 52 32 Larsen Larsen NNP cord-318625-hf7fgtnp 52 33 et et NNP cord-318625-hf7fgtnp 52 34 al al NNP cord-318625-hf7fgtnp 52 35 . . NNP cord-318625-hf7fgtnp 52 36 , , , cord-318625-hf7fgtnp 52 37 2006 2006 CD cord-318625-hf7fgtnp 52 38 ; ; : cord-318625-hf7fgtnp 52 39 Ponomarenko Ponomarenko NNP cord-318625-hf7fgtnp 52 40 and and CC cord-318625-hf7fgtnp 52 41 Bourne Bourne NNP cord-318625-hf7fgtnp 52 42 , , , cord-318625-hf7fgtnp 52 43 2007 2007 CD cord-318625-hf7fgtnp 52 44 ; ; : cord-318625-hf7fgtnp 52 45 Vita Vita NNP cord-318625-hf7fgtnp 52 46 et et FW cord-318625-hf7fgtnp 52 47 al al NNP cord-318625-hf7fgtnp 52 48 . . NNP cord-318625-hf7fgtnp 52 49 , , , cord-318625-hf7fgtnp 52 50 2019 2019 CD cord-318625-hf7fgtnp 52 51 ) ) -RRB- cord-318625-hf7fgtnp 52 52 . . . cord-318625-hf7fgtnp 53 1 The the DT cord-318625-hf7fgtnp 53 2 FASTA FASTA NNP cord-318625-hf7fgtnp 53 3 sequence sequence NN cord-318625-hf7fgtnp 53 4 of of IN cord-318625-hf7fgtnp 53 5 the the DT cord-318625-hf7fgtnp 53 6 targeted target VBN cord-318625-hf7fgtnp 53 7 protein protein NN cord-318625-hf7fgtnp 53 8 was be VBD cord-318625-hf7fgtnp 53 9 used use VBN cord-318625-hf7fgtnp 53 10 as as IN cord-318625-hf7fgtnp 53 11 an an DT cord-318625-hf7fgtnp 53 12 input input NN cord-318625-hf7fgtnp 53 13 for for IN cord-318625-hf7fgtnp 53 14 all all PDT cord-318625-hf7fgtnp 53 15 the the DT cord-318625-hf7fgtnp 53 16 default default NN cord-318625-hf7fgtnp 53 17 parameters parameter NNS cord-318625-hf7fgtnp 53 18 . . . cord-318625-hf7fgtnp 54 1 We -PRON- PRP cord-318625-hf7fgtnp 54 2 used use VBD cord-318625-hf7fgtnp 54 3 two two CD cord-318625-hf7fgtnp 54 4 web web NN cord-318625-hf7fgtnp 54 5 - - HYPH cord-318625-hf7fgtnp 54 6 based base VBN cord-318625-hf7fgtnp 54 7 tools tool NNS cord-318625-hf7fgtnp 54 8 for for IN cord-318625-hf7fgtnp 54 9 B b NN cord-318625-hf7fgtnp 54 10 - - HYPH cord-318625-hf7fgtnp 54 11 cell cell NN cord-318625-hf7fgtnp 54 12 epitope epitope NN cord-318625-hf7fgtnp 54 13 prediction prediction NN cord-318625-hf7fgtnp 54 14 : : : cord-318625-hf7fgtnp 54 15 the the DT cord-318625-hf7fgtnp 54 16 IEDB IEDB NNP cord-318625-hf7fgtnp 54 17 and and CC cord-318625-hf7fgtnp 54 18 ABCpred ABCpred NNP cord-318625-hf7fgtnp 54 19 servers server NNS cord-318625-hf7fgtnp 54 20 ( ( -LRB- cord-318625-hf7fgtnp 54 21 Saha Saha NNP cord-318625-hf7fgtnp 54 22 and and CC cord-318625-hf7fgtnp 54 23 Raghava Raghava NNP cord-318625-hf7fgtnp 54 24 , , , cord-318625-hf7fgtnp 54 25 2006 2006 CD cord-318625-hf7fgtnp 54 26 ) ) -RRB- cord-318625-hf7fgtnp 54 27 . . . cord-318625-hf7fgtnp 55 1 S s NN cord-318625-hf7fgtnp 55 2 protein protein NN cord-318625-hf7fgtnp 55 3 structure structure NN cord-318625-hf7fgtnp 55 4 from from IN cord-318625-hf7fgtnp 55 5 the the DT cord-318625-hf7fgtnp 55 6 protein protein NNP cord-318625-hf7fgtnp 55 7 data data NNP cord-318625-hf7fgtnp 55 8 bank bank NN cord-318625-hf7fgtnp 55 9 ( ( -LRB- cord-318625-hf7fgtnp 55 10 PDB PDB NNP cord-318625-hf7fgtnp 55 11 , , , cord-318625-hf7fgtnp 55 12 6VSB 6VSB NNP cord-318625-hf7fgtnp 55 13 ) ) -RRB- cord-318625-hf7fgtnp 55 14 was be VBD cord-318625-hf7fgtnp 55 15 analyzed analyze VBN cord-318625-hf7fgtnp 55 16 for for IN cord-318625-hf7fgtnp 55 17 linear linear JJ cord-318625-hf7fgtnp 55 18 and and CC cord-318625-hf7fgtnp 55 19 discontinuous discontinuous JJ cord-318625-hf7fgtnp 55 20 B b NN cord-318625-hf7fgtnp 55 21 - - HYPH cord-318625-hf7fgtnp 55 22 cell cell NN cord-318625-hf7fgtnp 55 23 epitopes epitope NNS cord-318625-hf7fgtnp 55 24 using use VBG cord-318625-hf7fgtnp 55 25 the the DT cord-318625-hf7fgtnp 55 26 ElliPro ElliPro NNP cord-318625-hf7fgtnp 55 27 module module NN cord-318625-hf7fgtnp 55 28 on on IN cord-318625-hf7fgtnp 55 29 the the DT cord-318625-hf7fgtnp 55 30 IEDB IEDB NNP cord-318625-hf7fgtnp 55 31 server server NN cord-318625-hf7fgtnp 55 32 with with IN cord-318625-hf7fgtnp 55 33 default default NN cord-318625-hf7fgtnp 55 34 settings setting NNS cord-318625-hf7fgtnp 55 35 ( ( -LRB- cord-318625-hf7fgtnp 55 36 Ponomarenko Ponomarenko NNP cord-318625-hf7fgtnp 55 37 et et FW cord-318625-hf7fgtnp 55 38 al al NNP cord-318625-hf7fgtnp 55 39 . . NNP cord-318625-hf7fgtnp 55 40 , , , cord-318625-hf7fgtnp 55 41 2008 2008 CD cord-318625-hf7fgtnp 55 42 ; ; : cord-318625-hf7fgtnp 55 43 Wrapp Wrapp NNP cord-318625-hf7fgtnp 55 44 et et NNP cord-318625-hf7fgtnp 55 45 al al NNP cord-318625-hf7fgtnp 55 46 . . NNP cord-318625-hf7fgtnp 55 47 , , , cord-318625-hf7fgtnp 55 48 2020 2020 CD cord-318625-hf7fgtnp 55 49 ) ) -RRB- cord-318625-hf7fgtnp 55 50 . . . cord-318625-hf7fgtnp 56 1 Also also RB cord-318625-hf7fgtnp 56 2 , , , cord-318625-hf7fgtnp 56 3 the the DT cord-318625-hf7fgtnp 56 4 ABCpred abcpred JJ cord-318625-hf7fgtnp 56 5 server server NN cord-318625-hf7fgtnp 56 6 was be VBD cord-318625-hf7fgtnp 56 7 used use VBN cord-318625-hf7fgtnp 56 8 to to TO cord-318625-hf7fgtnp 56 9 detect detect VB cord-318625-hf7fgtnp 56 10 B b NN cord-318625-hf7fgtnp 56 11 - - HYPH cord-318625-hf7fgtnp 56 12 cell cell NN cord-318625-hf7fgtnp 56 13 epitopes epitope NNS cord-318625-hf7fgtnp 56 14 using use VBG cord-318625-hf7fgtnp 56 15 the the DT cord-318625-hf7fgtnp 56 16 artificial artificial JJ cord-318625-hf7fgtnp 56 17 neural neural JJ cord-318625-hf7fgtnp 56 18 network network NN cord-318625-hf7fgtnp 56 19 ( ( -LRB- cord-318625-hf7fgtnp 56 20 ann ann NNP cord-318625-hf7fgtnp 56 21 ) ) -RRB- cord-318625-hf7fgtnp 56 22 method method NN cord-318625-hf7fgtnp 56 23 . . . cord-318625-hf7fgtnp 57 1 T t NN cord-318625-hf7fgtnp 57 2 - - HYPH cord-318625-hf7fgtnp 57 3 cell cell NN cord-318625-hf7fgtnp 57 4 epitopes epitope NNS cord-318625-hf7fgtnp 57 5 with with IN cord-318625-hf7fgtnp 57 6 a a DT cord-318625-hf7fgtnp 57 7 binding bind VBG cord-318625-hf7fgtnp 57 8 affinity affinity NN cord-318625-hf7fgtnp 57 9 towards towards IN cord-318625-hf7fgtnp 57 10 MHC MHC NNP cord-318625-hf7fgtnp 57 11 - - HYPH cord-318625-hf7fgtnp 57 12 I I NNP cord-318625-hf7fgtnp 57 13 and and CC cord-318625-hf7fgtnp 57 14 MHC MHC NNP cord-318625-hf7fgtnp 57 15 - - HYPH cord-318625-hf7fgtnp 57 16 II II NNP cord-318625-hf7fgtnp 57 17 alleles allele NNS cord-318625-hf7fgtnp 57 18 were be VBD cord-318625-hf7fgtnp 57 19 selected select VBN cord-318625-hf7fgtnp 57 20 to to TO cord-318625-hf7fgtnp 57 21 boost boost VB cord-318625-hf7fgtnp 57 22 up up RP cord-318625-hf7fgtnp 57 23 both both DT cord-318625-hf7fgtnp 57 24 cytotoxic cytotoxic JJ cord-318625-hf7fgtnp 57 25 T t NN cord-318625-hf7fgtnp 57 26 - - HYPH cord-318625-hf7fgtnp 57 27 cell cell NN cord-318625-hf7fgtnp 57 28 and and CC cord-318625-hf7fgtnp 57 29 helper helper NN cord-318625-hf7fgtnp 57 30 T t NN cord-318625-hf7fgtnp 57 31 - - HYPH cord-318625-hf7fgtnp 57 32 cell cell NN cord-318625-hf7fgtnp 57 33 mediated mediate VBN cord-318625-hf7fgtnp 57 34 immune immune JJ cord-318625-hf7fgtnp 57 35 response response NN cord-318625-hf7fgtnp 57 36 . . . cord-318625-hf7fgtnp 58 1 IEDB IEDB NNP cord-318625-hf7fgtnp 58 2 server server NN cord-318625-hf7fgtnp 58 3 was be VBD cord-318625-hf7fgtnp 58 4 used use VBN cord-318625-hf7fgtnp 58 5 to to TO cord-318625-hf7fgtnp 58 6 predict predict VB cord-318625-hf7fgtnp 58 7 the the DT cord-318625-hf7fgtnp 58 8 major major JJ cord-318625-hf7fgtnp 58 9 histocompatibility histocompatibility NN cord-318625-hf7fgtnp 58 10 complex complex NN cord-318625-hf7fgtnp 58 11 ( ( -LRB- cord-318625-hf7fgtnp 58 12 MHC)-I MHC)-I NNP cord-318625-hf7fgtnp 58 13 and and CC cord-318625-hf7fgtnp 58 14 MHC MHC NNP cord-318625-hf7fgtnp 58 15 - - HYPH cord-318625-hf7fgtnp 58 16 II II NNP cord-318625-hf7fgtnp 58 17 binding bind VBG cord-318625-hf7fgtnp 58 18 epitopes epitope NNS cord-318625-hf7fgtnp 58 19 for for IN cord-318625-hf7fgtnp 58 20 the the DT cord-318625-hf7fgtnp 58 21 targeted target VBN cord-318625-hf7fgtnp 58 22 protein protein NN cord-318625-hf7fgtnp 58 23 . . . cord-318625-hf7fgtnp 59 1 The the DT cord-318625-hf7fgtnp 59 2 reference reference NN cord-318625-hf7fgtnp 59 3 set set NN cord-318625-hf7fgtnp 59 4 of of IN cord-318625-hf7fgtnp 59 5 alleles allele NNS cord-318625-hf7fgtnp 59 6 was be VBD cord-318625-hf7fgtnp 59 7 used use VBN cord-318625-hf7fgtnp 59 8 for for IN cord-318625-hf7fgtnp 59 9 predicting predict VBG cord-318625-hf7fgtnp 59 10 the the DT cord-318625-hf7fgtnp 59 11 MHC MHC NNP cord-318625-hf7fgtnp 59 12 - - HYPH cord-318625-hf7fgtnp 59 13 I I NNP cord-318625-hf7fgtnp 59 14 and and CC cord-318625-hf7fgtnp 59 15 MHC MHC NNP cord-318625-hf7fgtnp 59 16 - - HYPH cord-318625-hf7fgtnp 59 17 II II NNP cord-318625-hf7fgtnp 59 18 T T NNP cord-318625-hf7fgtnp 59 19 - - HYPH cord-318625-hf7fgtnp 59 20 cell cell NN cord-318625-hf7fgtnp 59 21 epitopes epitope NNS cord-318625-hf7fgtnp 59 22 ( ( -LRB- cord-318625-hf7fgtnp 59 23 Karosiene Karosiene NNP cord-318625-hf7fgtnp 59 24 et et FW cord-318625-hf7fgtnp 59 25 al al NNP cord-318625-hf7fgtnp 59 26 . . NNP cord-318625-hf7fgtnp 59 27 , , , cord-318625-hf7fgtnp 59 28 2012 2012 CD cord-318625-hf7fgtnp 59 29 ; ; : cord-318625-hf7fgtnp 59 30 Nielsen Nielsen NNP cord-318625-hf7fgtnp 59 31 et et NNP cord-318625-hf7fgtnp 59 32 al al NNP cord-318625-hf7fgtnp 59 33 . . NNP cord-318625-hf7fgtnp 59 34 , , , cord-318625-hf7fgtnp 59 35 2007 2007 CD cord-318625-hf7fgtnp 59 36 ; ; : cord-318625-hf7fgtnp 59 37 Nielsen Nielsen NNP cord-318625-hf7fgtnp 59 38 et et NNP cord-318625-hf7fgtnp 59 39 al al NNP cord-318625-hf7fgtnp 59 40 . . NNP cord-318625-hf7fgtnp 59 41 , , , cord-318625-hf7fgtnp 59 42 2003 2003 CD cord-318625-hf7fgtnp 59 43 ; ; : cord-318625-hf7fgtnp 59 44 Peters Peters NNP cord-318625-hf7fgtnp 59 45 and and CC cord-318625-hf7fgtnp 59 46 Sette Sette NNP cord-318625-hf7fgtnp 59 47 , , , cord-318625-hf7fgtnp 59 48 2005 2005 CD cord-318625-hf7fgtnp 59 49 ; ; : cord-318625-hf7fgtnp 59 50 Sturniolo Sturniolo NNP cord-318625-hf7fgtnp 59 51 et et FW cord-318625-hf7fgtnp 59 52 al al NNP cord-318625-hf7fgtnp 59 53 . . NNP cord-318625-hf7fgtnp 59 54 , , , cord-318625-hf7fgtnp 59 55 1999 1999 CD cord-318625-hf7fgtnp 59 56 ) ) -RRB- cord-318625-hf7fgtnp 59 57 . . . cord-318625-hf7fgtnp 60 1 In in IN cord-318625-hf7fgtnp 60 2 our -PRON- PRP$ cord-318625-hf7fgtnp 60 3 study study NN cord-318625-hf7fgtnp 60 4 , , , cord-318625-hf7fgtnp 60 5 we -PRON- PRP cord-318625-hf7fgtnp 60 6 targeted target VBD cord-318625-hf7fgtnp 60 7 the the DT cord-318625-hf7fgtnp 60 8 S S NNP cord-318625-hf7fgtnp 60 9 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 60 10 of of IN cord-318625-hf7fgtnp 60 11 SARS SARS NNP cord-318625-hf7fgtnp 60 12 - - HYPH cord-318625-hf7fgtnp 60 13 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 60 14 as as IN cord-318625-hf7fgtnp 60 15 it -PRON- PRP cord-318625-hf7fgtnp 60 16 is be VBZ cord-318625-hf7fgtnp 60 17 present present JJ cord-318625-hf7fgtnp 60 18 outside outside IN cord-318625-hf7fgtnp 60 19 the the DT cord-318625-hf7fgtnp 60 20 virus virus NN cord-318625-hf7fgtnp 60 21 and and CC cord-318625-hf7fgtnp 60 22 interacts interact VBZ cord-318625-hf7fgtnp 60 23 with with IN cord-318625-hf7fgtnp 60 24 the the DT cord-318625-hf7fgtnp 60 25 host host NN cord-318625-hf7fgtnp 60 26 receptor receptor NN cord-318625-hf7fgtnp 60 27 . . . cord-318625-hf7fgtnp 61 1 At at IN cord-318625-hf7fgtnp 61 2 the the DT cord-318625-hf7fgtnp 61 3 time time NN cord-318625-hf7fgtnp 61 4 of of IN cord-318625-hf7fgtnp 61 5 the the DT cord-318625-hf7fgtnp 61 6 study study NN cord-318625-hf7fgtnp 61 7 , , , cord-318625-hf7fgtnp 61 8 there there EX cord-318625-hf7fgtnp 61 9 were be VBD cord-318625-hf7fgtnp 61 10 98 98 CD cord-318625-hf7fgtnp 61 11 J j NN cord-318625-hf7fgtnp 61 12 o o NN cord-318625-hf7fgtnp 61 13 u u NN cord-318625-hf7fgtnp 61 14 r r NN cord-318625-hf7fgtnp 61 15 n n NN cord-318625-hf7fgtnp 61 16 a a DT cord-318625-hf7fgtnp 61 17 l l NN cord-318625-hf7fgtnp 61 18 P p NN cord-318625-hf7fgtnp 61 19 r r NN cord-318625-hf7fgtnp 61 20 e e NN cord-318625-hf7fgtnp 61 21 -p -p NN cord-318625-hf7fgtnp 61 22 r r NN cord-318625-hf7fgtnp 61 23 o o NN cord-318625-hf7fgtnp 61 24 o o NN cord-318625-hf7fgtnp 61 25 f f NN cord-318625-hf7fgtnp 61 26 sequences sequence NNS cord-318625-hf7fgtnp 61 27 available available JJ cord-318625-hf7fgtnp 61 28 for for IN cord-318625-hf7fgtnp 61 29 the the DT cord-318625-hf7fgtnp 61 30 targeted target VBN cord-318625-hf7fgtnp 61 31 protein protein NN cord-318625-hf7fgtnp 61 32 of of IN cord-318625-hf7fgtnp 61 33 SARS SARS NNP cord-318625-hf7fgtnp 61 34 - - HYPH cord-318625-hf7fgtnp 61 35 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 61 36 . . . cord-318625-hf7fgtnp 62 1 The the DT cord-318625-hf7fgtnp 62 2 S S NNP cord-318625-hf7fgtnp 62 3 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 62 4 sequence sequence NN cord-318625-hf7fgtnp 62 5 is be VBZ cord-318625-hf7fgtnp 62 6 1,273 1,273 CD cord-318625-hf7fgtnp 62 7 amino amino JJ cord-318625-hf7fgtnp 62 8 acids acid NNS cord-318625-hf7fgtnp 62 9 long long RB cord-318625-hf7fgtnp 62 10 , , , cord-318625-hf7fgtnp 62 11 except except IN cord-318625-hf7fgtnp 62 12 for for IN cord-318625-hf7fgtnp 62 13 that that DT cord-318625-hf7fgtnp 62 14 of of IN cord-318625-hf7fgtnp 62 15 the the DT cord-318625-hf7fgtnp 62 16 virus virus NN cord-318625-hf7fgtnp 62 17 isolated isolate VBN cord-318625-hf7fgtnp 62 18 from from IN cord-318625-hf7fgtnp 62 19 Kerala Kerala NNP cord-318625-hf7fgtnp 62 20 ( ( -LRB- cord-318625-hf7fgtnp 62 21 India India NNP cord-318625-hf7fgtnp 62 22 ) ) -RRB- cord-318625-hf7fgtnp 62 23 , , , cord-318625-hf7fgtnp 62 24 which which WDT cord-318625-hf7fgtnp 62 25 is be VBZ cord-318625-hf7fgtnp 62 26 a a DT cord-318625-hf7fgtnp 62 27 1,272 1,272 CD cord-318625-hf7fgtnp 62 28 amino amino NN cord-318625-hf7fgtnp 62 29 acid acid NN cord-318625-hf7fgtnp 62 30 long long JJ cord-318625-hf7fgtnp 62 31 S s NN cord-318625-hf7fgtnp 62 32 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 62 33 ( ( -LRB- cord-318625-hf7fgtnp 62 34 GenBank GenBank NNP cord-318625-hf7fgtnp 62 35 accession accession NN cord-318625-hf7fgtnp 62 36 number number NN cord-318625-hf7fgtnp 62 37 MT012098 mt012098 NN cord-318625-hf7fgtnp 62 38 ) ) -RRB- cord-318625-hf7fgtnp 62 39 . . . cord-318625-hf7fgtnp 63 1 Our -PRON- PRP$ cord-318625-hf7fgtnp 63 2 interest interest NN cord-318625-hf7fgtnp 63 3 here here RB cord-318625-hf7fgtnp 63 4 was be VBD cord-318625-hf7fgtnp 63 5 to to TO cord-318625-hf7fgtnp 63 6 determine determine VB cord-318625-hf7fgtnp 63 7 conserved conserve VBN cord-318625-hf7fgtnp 63 8 regions region NNS cord-318625-hf7fgtnp 63 9 first first RB cord-318625-hf7fgtnp 63 10 and and CC cord-318625-hf7fgtnp 63 11 then then RB cord-318625-hf7fgtnp 63 12 determine determine VB cord-318625-hf7fgtnp 63 13 surface surface NN cord-318625-hf7fgtnp 63 14 - - HYPH cord-318625-hf7fgtnp 63 15 exposed expose VBN cord-318625-hf7fgtnp 63 16 regions region NNS cord-318625-hf7fgtnp 63 17 , , , cord-318625-hf7fgtnp 63 18 which which WDT cord-318625-hf7fgtnp 63 19 are be VBP cord-318625-hf7fgtnp 63 20 potential potential JJ cord-318625-hf7fgtnp 63 21 epitopes epitope NNS cord-318625-hf7fgtnp 63 22 to to TO cord-318625-hf7fgtnp 63 23 generate generate VB cord-318625-hf7fgtnp 63 24 an an DT cord-318625-hf7fgtnp 63 25 immune immune JJ cord-318625-hf7fgtnp 63 26 response response NN cord-318625-hf7fgtnp 63 27 . . . cord-318625-hf7fgtnp 64 1 We -PRON- PRP cord-318625-hf7fgtnp 64 2 found find VBD cord-318625-hf7fgtnp 64 3 that that IN cord-318625-hf7fgtnp 64 4 sequences sequence NNS cord-318625-hf7fgtnp 64 5 among among IN cord-318625-hf7fgtnp 64 6 all all PDT cord-318625-hf7fgtnp 64 7 the the DT cord-318625-hf7fgtnp 64 8 S S NNP cord-318625-hf7fgtnp 64 9 proteins protein NNS cord-318625-hf7fgtnp 64 10 in in IN cord-318625-hf7fgtnp 64 11 the the DT cord-318625-hf7fgtnp 64 12 analysis analysis NN cord-318625-hf7fgtnp 64 13 are be VBP cord-318625-hf7fgtnp 64 14 least least JJS cord-318625-hf7fgtnp 64 15 variable variable JJ cord-318625-hf7fgtnp 64 16 and and CC cord-318625-hf7fgtnp 64 17 highly highly RB cord-318625-hf7fgtnp 64 18 conserved conserve VBN cord-318625-hf7fgtnp 64 19 , , , cord-318625-hf7fgtnp 64 20 as as IN cord-318625-hf7fgtnp 64 21 shown show VBN cord-318625-hf7fgtnp 64 22 in in IN cord-318625-hf7fgtnp 64 23 ASA ASA NNP cord-318625-hf7fgtnp 64 24 value value NN cord-318625-hf7fgtnp 64 25 are be VBP cord-318625-hf7fgtnp 64 26 more more JJR cord-318625-hf7fgtnp 64 27 surface surface NN cord-318625-hf7fgtnp 64 28 exposed expose VBN cord-318625-hf7fgtnp 64 29 compared compare VBN cord-318625-hf7fgtnp 64 30 to to IN cord-318625-hf7fgtnp 64 31 others other NNS cord-318625-hf7fgtnp 64 32 . . . cord-318625-hf7fgtnp 65 1 We -PRON- PRP cord-318625-hf7fgtnp 65 2 identified identify VBD cord-318625-hf7fgtnp 65 3 a a DT cord-318625-hf7fgtnp 65 4 total total NN cord-318625-hf7fgtnp 65 5 of of IN cord-318625-hf7fgtnp 65 6 24 24 CD cord-318625-hf7fgtnp 65 7 peptides peptide NNS cord-318625-hf7fgtnp 65 8 of of IN cord-318625-hf7fgtnp 65 9 varying vary VBG cord-318625-hf7fgtnp 65 10 lengths length NNS cord-318625-hf7fgtnp 65 11 , , , cord-318625-hf7fgtnp 65 12 which which WDT cord-318625-hf7fgtnp 65 13 were be VBD cord-318625-hf7fgtnp 65 14 selected select VBN cord-318625-hf7fgtnp 65 15 based base VBN cord-318625-hf7fgtnp 65 16 on on IN cord-318625-hf7fgtnp 65 17 high high JJ cord-318625-hf7fgtnp 65 18 ASA ASA NNP cord-318625-hf7fgtnp 65 19 values value NNS cord-318625-hf7fgtnp 65 20 ( ( -LRB- cord-318625-hf7fgtnp 65 21 Table table NN cord-318625-hf7fgtnp 65 22 1 1 CD cord-318625-hf7fgtnp 65 23 ) ) -RRB- cord-318625-hf7fgtnp 65 24 . . . cord-318625-hf7fgtnp 66 1 The the DT cord-318625-hf7fgtnp 66 2 potential potential JJ cord-318625-hf7fgtnp 66 3 epitope epitope NN cord-318625-hf7fgtnp 66 4 regions region NNS cord-318625-hf7fgtnp 66 5 were be VBD cord-318625-hf7fgtnp 66 6 predicted predict VBN cord-318625-hf7fgtnp 66 7 using use VBG cord-318625-hf7fgtnp 66 8 the the DT cord-318625-hf7fgtnp 66 9 sequence sequence NN cord-318625-hf7fgtnp 66 10 of of IN cord-318625-hf7fgtnp 66 11 the the DT cord-318625-hf7fgtnp 66 12 S S NNP cord-318625-hf7fgtnp 66 13 protein protein NN cord-318625-hf7fgtnp 66 14 of of IN cord-318625-hf7fgtnp 66 15 SARS SARS NNP cord-318625-hf7fgtnp 66 16 - - : cord-318625-hf7fgtnp 66 17 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 66 18 that that WDT cord-318625-hf7fgtnp 66 19 showed show VBD cord-318625-hf7fgtnp 66 20 the the DT cord-318625-hf7fgtnp 66 21 least least JJS cord-318625-hf7fgtnp 66 22 variability variability NN cord-318625-hf7fgtnp 67 1 ( ( -LRB- cord-318625-hf7fgtnp 67 2 GenBank GenBank NNP cord-318625-hf7fgtnp 67 3 accession accession NN cord-318625-hf7fgtnp 67 4 number number NN cord-318625-hf7fgtnp 67 5 NC_045512 NC_045512 NNP cord-318625-hf7fgtnp 67 6 ) ) -RRB- cord-318625-hf7fgtnp 67 7 . . . cord-318625-hf7fgtnp 68 1 The the DT cord-318625-hf7fgtnp 68 2 potential potential JJ cord-318625-hf7fgtnp 68 3 epitopes epitope NNS cord-318625-hf7fgtnp 68 4 are be VBP cord-318625-hf7fgtnp 68 5 represented represent VBN cord-318625-hf7fgtnp 68 6 by by IN cord-318625-hf7fgtnp 68 7 blue blue JJ cord-318625-hf7fgtnp 68 8 peaks peak NNS cord-318625-hf7fgtnp 68 9 , , , cord-318625-hf7fgtnp 68 10 while while IN cord-318625-hf7fgtnp 68 11 green green JJ cord-318625-hf7fgtnp 68 12 - - HYPH cord-318625-hf7fgtnp 68 13 colored colored JJ cord-318625-hf7fgtnp 68 14 slopes slope NNS cord-318625-hf7fgtnp 68 15 represent represent VBP cord-318625-hf7fgtnp 68 16 non non JJ cord-318625-hf7fgtnp 68 17 - - JJ cord-318625-hf7fgtnp 68 18 epitopic epitopic JJ cord-318625-hf7fgtnp 68 19 regions region NNS cord-318625-hf7fgtnp 68 20 ( ( -LRB- cord-318625-hf7fgtnp 68 21 Figure figure NN cord-318625-hf7fgtnp 68 22 2 2 CD cord-318625-hf7fgtnp 68 23 ) ) -RRB- cord-318625-hf7fgtnp 68 24 . . . cord-318625-hf7fgtnp 69 1 The the DT cord-318625-hf7fgtnp 69 2 existence existence NN cord-318625-hf7fgtnp 69 3 of of IN cord-318625-hf7fgtnp 69 4 B b NN cord-318625-hf7fgtnp 69 5 - - HYPH cord-318625-hf7fgtnp 69 6 cell cell NN cord-318625-hf7fgtnp 69 7 linear linear JJ cord-318625-hf7fgtnp 69 8 and and CC cord-318625-hf7fgtnp 69 9 discontinuous discontinuous JJ cord-318625-hf7fgtnp 69 10 ( ( -LRB- cord-318625-hf7fgtnp 69 11 conformational conformational JJ cord-318625-hf7fgtnp 69 12 ) ) -RRB- cord-318625-hf7fgtnp 69 13 epitopes epitope NNS cord-318625-hf7fgtnp 69 14 within within IN cord-318625-hf7fgtnp 69 15 the the DT cord-318625-hf7fgtnp 69 16 identified identify VBN cord-318625-hf7fgtnp 69 17 segments segment NNS cord-318625-hf7fgtnp 69 18 could could MD cord-318625-hf7fgtnp 69 19 help help VB cord-318625-hf7fgtnp 69 20 us -PRON- PRP cord-318625-hf7fgtnp 69 21 to to TO cord-318625-hf7fgtnp 69 22 identify identify VB cord-318625-hf7fgtnp 69 23 the the DT cord-318625-hf7fgtnp 69 24 peptides peptide NNS cord-318625-hf7fgtnp 69 25 , , , cord-318625-hf7fgtnp 69 26 which which WDT cord-318625-hf7fgtnp 69 27 can can MD cord-318625-hf7fgtnp 69 28 elicit elicit VB cord-318625-hf7fgtnp 69 29 an an DT cord-318625-hf7fgtnp 69 30 immune immune JJ cord-318625-hf7fgtnp 69 31 response response NN cord-318625-hf7fgtnp 69 32 ( ( -LRB- cord-318625-hf7fgtnp 69 33 Purcell Purcell NNP cord-318625-hf7fgtnp 69 34 et et NNP cord-318625-hf7fgtnp 69 35 al al NNP cord-318625-hf7fgtnp 69 36 . . NNP cord-318625-hf7fgtnp 69 37 , , , cord-318625-hf7fgtnp 69 38 2007 2007 CD cord-318625-hf7fgtnp 69 39 ) ) -RRB- cord-318625-hf7fgtnp 69 40 . . . cord-318625-hf7fgtnp 70 1 We -PRON- PRP cord-318625-hf7fgtnp 70 2 identified identify VBD cord-318625-hf7fgtnp 70 3 18 18 CD cord-318625-hf7fgtnp 70 4 linear linear JJ cord-318625-hf7fgtnp 70 5 epitopes epitope NNS cord-318625-hf7fgtnp 70 6 , , , cord-318625-hf7fgtnp 70 7 predicted predict VBN cord-318625-hf7fgtnp 70 8 by by IN cord-318625-hf7fgtnp 70 9 ElliPro ElliPro NNP cord-318625-hf7fgtnp 70 10 ( ( -LRB- cord-318625-hf7fgtnp 70 11 IEDB IEDB NNP cord-318625-hf7fgtnp 70 12 ) ) -RRB- cord-318625-hf7fgtnp 70 13 , , , cord-318625-hf7fgtnp 70 14 which which WDT cord-318625-hf7fgtnp 70 15 contained contain VBD cord-318625-hf7fgtnp 70 16 regions region NNS cord-318625-hf7fgtnp 70 17 from from IN cord-318625-hf7fgtnp 70 18 19 19 CD cord-318625-hf7fgtnp 70 19 of of IN cord-318625-hf7fgtnp 70 20 our -PRON- PRP$ cord-318625-hf7fgtnp 70 21 selected select VBN cord-318625-hf7fgtnp 70 22 peptides peptide NNS cord-318625-hf7fgtnp 70 23 ( ( -LRB- cord-318625-hf7fgtnp 70 24 highlighted highlight VBN cord-318625-hf7fgtnp 70 25 in in IN cord-318625-hf7fgtnp 70 26 red red NN cord-318625-hf7fgtnp 70 27 in in IN cord-318625-hf7fgtnp 70 28 Table Table NNP cord-318625-hf7fgtnp 70 29 2 2 CD cord-318625-hf7fgtnp 70 30 ) ) -RRB- cord-318625-hf7fgtnp 70 31 . . . cord-318625-hf7fgtnp 71 1 These these DT cord-318625-hf7fgtnp 71 2 identified identify VBN cord-318625-hf7fgtnp 71 3 B b NN cord-318625-hf7fgtnp 71 4 - - HYPH cord-318625-hf7fgtnp 71 5 cell cell NN cord-318625-hf7fgtnp 71 6 linear linear JJ cord-318625-hf7fgtnp 71 7 epitopes epitope NNS cord-318625-hf7fgtnp 71 8 were be VBD cord-318625-hf7fgtnp 71 9 placed place VBN cord-318625-hf7fgtnp 71 10 based base VBN cord-318625-hf7fgtnp 71 11 on on IN cord-318625-hf7fgtnp 71 12 their -PRON- PRP$ cord-318625-hf7fgtnp 71 13 positional positional JJ cord-318625-hf7fgtnp 71 14 value value NN cord-318625-hf7fgtnp 71 15 and and CC cord-318625-hf7fgtnp 71 16 scores score NNS cord-318625-hf7fgtnp 71 17 . . . cord-318625-hf7fgtnp 72 1 Epitopes epitope NNS cord-318625-hf7fgtnp 72 2 with with IN cord-318625-hf7fgtnp 72 3 high high JJ cord-318625-hf7fgtnp 72 4 scores score NNS cord-318625-hf7fgtnp 72 5 have have VBP cord-318625-hf7fgtnp 72 6 more more JJR cord-318625-hf7fgtnp 72 7 potential potential NN cord-318625-hf7fgtnp 72 8 for for IN cord-318625-hf7fgtnp 72 9 antibody antibody NN cord-318625-hf7fgtnp 72 10 binding binding NN cord-318625-hf7fgtnp 72 11 . . . cord-318625-hf7fgtnp 73 1 Five five CD cord-318625-hf7fgtnp 73 2 of of IN cord-318625-hf7fgtnp 73 3 our -PRON- PRP$ cord-318625-hf7fgtnp 73 4 selected select VBN cord-318625-hf7fgtnp 73 5 J J NNP cord-318625-hf7fgtnp 73 6 o o NN cord-318625-hf7fgtnp 73 7 u u NN cord-318625-hf7fgtnp 73 8 r r NN cord-318625-hf7fgtnp 73 9 n n NN cord-318625-hf7fgtnp 73 10 a a DT cord-318625-hf7fgtnp 73 11 l l NN cord-318625-hf7fgtnp 73 12 P p NN cord-318625-hf7fgtnp 73 13 r r NN cord-318625-hf7fgtnp 73 14 e e NN cord-318625-hf7fgtnp 73 15 -p -p NN cord-318625-hf7fgtnp 73 16 r r NN cord-318625-hf7fgtnp 74 1 o o UH cord-318625-hf7fgtnp 75 1 o o UH cord-318625-hf7fgtnp 76 1 f f NNP cord-318625-hf7fgtnp 76 2 peptides peptides NNP cord-318625-hf7fgtnp 76 3 ( ( -LRB- cord-318625-hf7fgtnp 76 4 peptide peptide NN cord-318625-hf7fgtnp 76 5 numbers number NNS cord-318625-hf7fgtnp 76 6 3 3 CD cord-318625-hf7fgtnp 76 7 , , , cord-318625-hf7fgtnp 76 8 5 5 CD cord-318625-hf7fgtnp 76 9 , , , cord-318625-hf7fgtnp 76 10 19 19 CD cord-318625-hf7fgtnp 76 11 , , , cord-318625-hf7fgtnp 76 12 23 23 CD cord-318625-hf7fgtnp 76 13 , , , cord-318625-hf7fgtnp 76 14 and and CC cord-318625-hf7fgtnp 76 15 24 24 CD cord-318625-hf7fgtnp 76 16 in in IN cord-318625-hf7fgtnp 76 17 Table Table NNP cord-318625-hf7fgtnp 76 18 1 1 CD cord-318625-hf7fgtnp 76 19 ) ) -RRB- cord-318625-hf7fgtnp 76 20 were be VBD cord-318625-hf7fgtnp 76 21 not not RB cord-318625-hf7fgtnp 76 22 considered consider VBN cord-318625-hf7fgtnp 76 23 as as IN cord-318625-hf7fgtnp 76 24 potential potential JJ cord-318625-hf7fgtnp 76 25 linear linear JJ cord-318625-hf7fgtnp 76 26 B b NN cord-318625-hf7fgtnp 76 27 - - HYPH cord-318625-hf7fgtnp 76 28 cell cell NN cord-318625-hf7fgtnp 76 29 epitopes epitope NNS cord-318625-hf7fgtnp 76 30 . . . cord-318625-hf7fgtnp 77 1 Some some DT cord-318625-hf7fgtnp 77 2 parts part NNS cord-318625-hf7fgtnp 77 3 of of IN cord-318625-hf7fgtnp 77 4 our -PRON- PRP$ cord-318625-hf7fgtnp 77 5 identified identify VBN cord-318625-hf7fgtnp 77 6 epitopes epitope NNS cord-318625-hf7fgtnp 77 7 were be VBD cord-318625-hf7fgtnp 77 8 in in IN cord-318625-hf7fgtnp 77 9 accordance accordance NN cord-318625-hf7fgtnp 77 10 with with IN cord-318625-hf7fgtnp 77 11 epitopes epitope NNS cord-318625-hf7fgtnp 77 12 recognized recognize VBN cord-318625-hf7fgtnp 77 13 in in IN cord-318625-hf7fgtnp 77 14 an an DT cord-318625-hf7fgtnp 77 15 earlier early JJR cord-318625-hf7fgtnp 77 16 study study NN cord-318625-hf7fgtnp 77 17 ( ( -LRB- cord-318625-hf7fgtnp 77 18 Ahmed Ahmed NNP cord-318625-hf7fgtnp 77 19 et et NNP cord-318625-hf7fgtnp 77 20 al al NNP cord-318625-hf7fgtnp 77 21 . . NNP cord-318625-hf7fgtnp 77 22 , , , cord-318625-hf7fgtnp 77 23 2020 2020 CD cord-318625-hf7fgtnp 77 24 ) ) -RRB- cord-318625-hf7fgtnp 77 25 , , , cord-318625-hf7fgtnp 77 26 which which WDT cord-318625-hf7fgtnp 77 27 further further RB cord-318625-hf7fgtnp 77 28 supports support VBZ cord-318625-hf7fgtnp 77 29 the the DT cord-318625-hf7fgtnp 77 30 credibility credibility NN cord-318625-hf7fgtnp 77 31 of of IN cord-318625-hf7fgtnp 77 32 our -PRON- PRP$ cord-318625-hf7fgtnp 77 33 identified identify VBN cord-318625-hf7fgtnp 77 34 epitopes epitope NNS cord-318625-hf7fgtnp 77 35 . . . cord-318625-hf7fgtnp 78 1 Using use VBG cord-318625-hf7fgtnp 78 2 the the DT cord-318625-hf7fgtnp 78 3 same same JJ cord-318625-hf7fgtnp 78 4 module module NN cord-318625-hf7fgtnp 78 5 , , , cord-318625-hf7fgtnp 78 6 B b NN cord-318625-hf7fgtnp 78 7 - - HYPH cord-318625-hf7fgtnp 78 8 cell cell NN cord-318625-hf7fgtnp 78 9 discontinuous discontinuous JJ cord-318625-hf7fgtnp 78 10 epitopes epitope NNS cord-318625-hf7fgtnp 78 11 were be VBD cord-318625-hf7fgtnp 78 12 predicted predict VBN cord-318625-hf7fgtnp 78 13 , , , cord-318625-hf7fgtnp 78 14 which which WDT cord-318625-hf7fgtnp 78 15 gave give VBD cord-318625-hf7fgtnp 78 16 16 16 CD cord-318625-hf7fgtnp 78 17 epitope epitope NN cord-318625-hf7fgtnp 78 18 regions region NNS cord-318625-hf7fgtnp 78 19 that that WDT cord-318625-hf7fgtnp 78 20 contained contain VBD cord-318625-hf7fgtnp 78 21 regions region NNS cord-318625-hf7fgtnp 78 22 from from IN cord-318625-hf7fgtnp 78 23 18 18 CD cord-318625-hf7fgtnp 78 24 of of IN cord-318625-hf7fgtnp 78 25 our -PRON- PRP$ cord-318625-hf7fgtnp 78 26 selected select VBN cord-318625-hf7fgtnp 78 27 peptides peptide NNS cord-318625-hf7fgtnp 78 28 ( ( -LRB- cord-318625-hf7fgtnp 78 29 highlighted highlight VBN cord-318625-hf7fgtnp 78 30 in in IN cord-318625-hf7fgtnp 78 31 red red NN cord-318625-hf7fgtnp 78 32 in in IN cord-318625-hf7fgtnp 78 33 Table Table NNP cord-318625-hf7fgtnp 78 34 S1 S1 NNP cord-318625-hf7fgtnp 78 35 ) ) -RRB- cord-318625-hf7fgtnp 78 36 . . . cord-318625-hf7fgtnp 79 1 Six six CD cord-318625-hf7fgtnp 79 2 peptides peptide NNS cord-318625-hf7fgtnp 79 3 ( ( -LRB- cord-318625-hf7fgtnp 79 4 peptide peptide NN cord-318625-hf7fgtnp 79 5 numbers number NNS cord-318625-hf7fgtnp 79 6 3 3 CD cord-318625-hf7fgtnp 79 7 , , , cord-318625-hf7fgtnp 79 8 5 5 CD cord-318625-hf7fgtnp 79 9 , , , cord-318625-hf7fgtnp 79 10 14 14 CD cord-318625-hf7fgtnp 79 11 , , , cord-318625-hf7fgtnp 79 12 19 19 CD cord-318625-hf7fgtnp 79 13 , , , cord-318625-hf7fgtnp 79 14 23 23 CD cord-318625-hf7fgtnp 79 15 , , , cord-318625-hf7fgtnp 79 16 and and CC cord-318625-hf7fgtnp 79 17 24 24 CD cord-318625-hf7fgtnp 79 18 in in IN cord-318625-hf7fgtnp 79 19 Table Table NNP cord-318625-hf7fgtnp 79 20 1 1 CD cord-318625-hf7fgtnp 79 21 ) ) -RRB- cord-318625-hf7fgtnp 79 22 were be VBD cord-318625-hf7fgtnp 79 23 not not RB cord-318625-hf7fgtnp 79 24 predicted predict VBN cord-318625-hf7fgtnp 79 25 as as IN cord-318625-hf7fgtnp 79 26 discontinuous discontinuous JJ cord-318625-hf7fgtnp 79 27 B b NN cord-318625-hf7fgtnp 79 28 - - HYPH cord-318625-hf7fgtnp 79 29 cell cell NN cord-318625-hf7fgtnp 79 30 epitopes epitope NNS cord-318625-hf7fgtnp 79 31 . . . cord-318625-hf7fgtnp 80 1 To to TO cord-318625-hf7fgtnp 80 2 further further RB cord-318625-hf7fgtnp 80 3 confirm confirm VB cord-318625-hf7fgtnp 80 4 , , , cord-318625-hf7fgtnp 80 5 we -PRON- PRP cord-318625-hf7fgtnp 80 6 used use VBD cord-318625-hf7fgtnp 80 7 the the DT cord-318625-hf7fgtnp 80 8 ABCpred abcpred JJ cord-318625-hf7fgtnp 80 9 server server NN cord-318625-hf7fgtnp 80 10 to to TO cord-318625-hf7fgtnp 80 11 detect detect VB cord-318625-hf7fgtnp 80 12 B b NN cord-318625-hf7fgtnp 80 13 - - HYPH cord-318625-hf7fgtnp 80 14 cell cell NN cord-318625-hf7fgtnp 80 15 epitopes epitope NNS cord-318625-hf7fgtnp 80 16 , , , cord-318625-hf7fgtnp 80 17 with with IN cord-318625-hf7fgtnp 80 18 a a DT cord-318625-hf7fgtnp 80 19 default default NN cord-318625-hf7fgtnp 80 20 threshold threshold NN cord-318625-hf7fgtnp 80 21 of of IN cord-318625-hf7fgtnp 80 22 0.51 0.51 CD cord-318625-hf7fgtnp 80 23 . . . cord-318625-hf7fgtnp 81 1 It -PRON- PRP cord-318625-hf7fgtnp 81 2 identified identify VBD cord-318625-hf7fgtnp 81 3 various various JJ cord-318625-hf7fgtnp 81 4 epitopes epitope NNS cord-318625-hf7fgtnp 81 5 with with IN cord-318625-hf7fgtnp 81 6 different different JJ cord-318625-hf7fgtnp 81 7 lengths length NNS cord-318625-hf7fgtnp 81 8 and and CC cord-318625-hf7fgtnp 81 9 scores score NNS cord-318625-hf7fgtnp 81 10 . . . cord-318625-hf7fgtnp 82 1 Out out IN cord-318625-hf7fgtnp 82 2 of of IN cord-318625-hf7fgtnp 82 3 those those DT cord-318625-hf7fgtnp 82 4 , , , cord-318625-hf7fgtnp 82 5 the the DT cord-318625-hf7fgtnp 82 6 regions region NNS cord-318625-hf7fgtnp 82 7 that that WDT cord-318625-hf7fgtnp 82 8 contained contain VBD cord-318625-hf7fgtnp 82 9 our -PRON- PRP$ cord-318625-hf7fgtnp 82 10 selected select VBN cord-318625-hf7fgtnp 82 11 peptides peptide NNS cord-318625-hf7fgtnp 82 12 are be VBP cord-318625-hf7fgtnp 82 13 highlighted highlight VBN cord-318625-hf7fgtnp 82 14 in in IN cord-318625-hf7fgtnp 82 15 red red NN cord-318625-hf7fgtnp 82 16 in in IN cord-318625-hf7fgtnp 82 17 Table3 Table3 NNP cord-318625-hf7fgtnp 82 18 . . . cord-318625-hf7fgtnp 83 1 A a DT cord-318625-hf7fgtnp 83 2 high high JJ cord-318625-hf7fgtnp 83 3 score score NN cord-318625-hf7fgtnp 83 4 represents represent VBZ cord-318625-hf7fgtnp 83 5 good good JJ cord-318625-hf7fgtnp 83 6 binding bind VBG cord-318625-hf7fgtnp 83 7 affinity affinity NN cord-318625-hf7fgtnp 83 8 with with IN cord-318625-hf7fgtnp 83 9 epitopes epitope NNS cord-318625-hf7fgtnp 83 10 ; ; : cord-318625-hf7fgtnp 83 11 most most JJS cord-318625-hf7fgtnp 83 12 of of IN cord-318625-hf7fgtnp 83 13 our -PRON- PRP$ cord-318625-hf7fgtnp 83 14 peptides peptide NNS cord-318625-hf7fgtnp 83 15 scored score VBD cord-318625-hf7fgtnp 83 16 more more JJR cord-318625-hf7fgtnp 83 17 than than IN cord-318625-hf7fgtnp 83 18 0.7 0.7 CD cord-318625-hf7fgtnp 83 19 and and CC cord-318625-hf7fgtnp 83 20 were be VBD cord-318625-hf7fgtnp 83 21 predicted predict VBN cord-318625-hf7fgtnp 83 22 as as IN cord-318625-hf7fgtnp 83 23 linear linear NNP cord-318625-hf7fgtnp 83 24 B b NN cord-318625-hf7fgtnp 83 25 - - HYPH cord-318625-hf7fgtnp 83 26 cell cell NN cord-318625-hf7fgtnp 83 27 epitopes epitope NNS cord-318625-hf7fgtnp 83 28 . . . cord-318625-hf7fgtnp 84 1 We -PRON- PRP cord-318625-hf7fgtnp 84 2 used use VBD cord-318625-hf7fgtnp 84 3 the the DT cord-318625-hf7fgtnp 84 4 IEDB IEDB NNP cord-318625-hf7fgtnp 84 5 server server NN cord-318625-hf7fgtnp 84 6 to to TO cord-318625-hf7fgtnp 84 7 determine determine VB cord-318625-hf7fgtnp 84 8 the the DT cord-318625-hf7fgtnp 84 9 binding bind VBG cord-318625-hf7fgtnp 84 10 affinity affinity NN cord-318625-hf7fgtnp 84 11 for for IN cord-318625-hf7fgtnp 84 12 the the DT cord-318625-hf7fgtnp 84 13 human human JJ cord-318625-hf7fgtnp 84 14 leucocyte leucocyte NNP cord-318625-hf7fgtnp 84 15 antigen antigen NNP cord-318625-hf7fgtnp 84 16 ( ( -LRB- cord-318625-hf7fgtnp 84 17 HLA HLA NNP cord-318625-hf7fgtnp 84 18 ) ) -RRB- cord-318625-hf7fgtnp 84 19 . . . cord-318625-hf7fgtnp 85 1 As as IN cord-318625-hf7fgtnp 85 2 recommended recommend VBN cord-318625-hf7fgtnp 85 3 by by IN cord-318625-hf7fgtnp 85 4 the the DT cord-318625-hf7fgtnp 85 5 IEDB IEDB NNP cord-318625-hf7fgtnp 85 6 server server NN cord-318625-hf7fgtnp 85 7 , , , cord-318625-hf7fgtnp 85 8 reference reference NN cord-318625-hf7fgtnp 85 9 HLA HLA NNP cord-318625-hf7fgtnp 85 10 allele allele NN cord-318625-hf7fgtnp 85 11 sets set NNS cord-318625-hf7fgtnp 85 12 were be VBD cord-318625-hf7fgtnp 85 13 used use VBN cord-318625-hf7fgtnp 85 14 for for IN cord-318625-hf7fgtnp 85 15 the the DT cord-318625-hf7fgtnp 85 16 prediction prediction NN cord-318625-hf7fgtnp 85 17 of of IN cord-318625-hf7fgtnp 85 18 MHC MHC NNP cord-318625-hf7fgtnp 85 19 - - HYPH cord-318625-hf7fgtnp 85 20 I I NNP cord-318625-hf7fgtnp 85 21 and and CC cord-318625-hf7fgtnp 85 22 MHC MHC NNP cord-318625-hf7fgtnp 85 23 - - HYPH cord-318625-hf7fgtnp 85 24 II II NNP cord-318625-hf7fgtnp 85 25 T T NNP cord-318625-hf7fgtnp 85 26 - - HYPH cord-318625-hf7fgtnp 85 27 cell cell NN cord-318625-hf7fgtnp 85 28 epitopes epitope NNS cord-318625-hf7fgtnp 85 29 , , , cord-318625-hf7fgtnp 85 30 as as IN cord-318625-hf7fgtnp 85 31 they -PRON- PRP cord-318625-hf7fgtnp 85 32 provide provide VBP cord-318625-hf7fgtnp 85 33 comprehensive comprehensive JJ cord-318625-hf7fgtnp 85 34 coverage coverage NN cord-318625-hf7fgtnp 85 35 of of IN cord-318625-hf7fgtnp 85 36 the the DT cord-318625-hf7fgtnp 85 37 population population NN cord-318625-hf7fgtnp 85 38 . . . cord-318625-hf7fgtnp 86 1 All all PDT cord-318625-hf7fgtnp 86 2 the the DT cord-318625-hf7fgtnp 86 3 predictions prediction NNS cord-318625-hf7fgtnp 86 4 were be VBD cord-318625-hf7fgtnp 86 5 made make VBN cord-318625-hf7fgtnp 86 6 using use VBG cord-318625-hf7fgtnp 86 7 IEDB IEDB NNP cord-318625-hf7fgtnp 86 8 recommended recommend VBD cord-318625-hf7fgtnp 86 9 procedures procedure NNS cord-318625-hf7fgtnp 86 10 . . . cord-318625-hf7fgtnp 87 1 The the DT cord-318625-hf7fgtnp 87 2 list list NN cord-318625-hf7fgtnp 87 3 of of IN cord-318625-hf7fgtnp 87 4 binding bind VBG cord-318625-hf7fgtnp 87 5 affinities affinity NNS cord-318625-hf7fgtnp 87 6 for for IN cord-318625-hf7fgtnp 87 7 MHC MHC NNP cord-318625-hf7fgtnp 87 8 - - HYPH cord-318625-hf7fgtnp 87 9 I I NNP cord-318625-hf7fgtnp 87 10 T t NN cord-318625-hf7fgtnp 87 11 - - HYPH cord-318625-hf7fgtnp 87 12 cell cell NN cord-318625-hf7fgtnp 87 13 epitopes epitope NNS cord-318625-hf7fgtnp 87 14 is be VBZ cord-318625-hf7fgtnp 87 15 given give VBN cord-318625-hf7fgtnp 87 16 in in IN cord-318625-hf7fgtnp 87 17 Table Table NNP cord-318625-hf7fgtnp 87 18 S2 S2 NNP cord-318625-hf7fgtnp 87 19 , , , cord-318625-hf7fgtnp 87 20 where where WRB cord-318625-hf7fgtnp 87 21 low low JJ cord-318625-hf7fgtnp 87 22 rank rank NN cord-318625-hf7fgtnp 87 23 represents represent VBZ cord-318625-hf7fgtnp 87 24 high high JJ cord-318625-hf7fgtnp 87 25 binding bind VBG cord-318625-hf7fgtnp 87 26 affinity affinity NN cord-318625-hf7fgtnp 87 27 . . . cord-318625-hf7fgtnp 88 1 Similarly similarly RB cord-318625-hf7fgtnp 88 2 , , , cord-318625-hf7fgtnp 88 3 the the DT cord-318625-hf7fgtnp 88 4 list list NN cord-318625-hf7fgtnp 88 5 of of IN cord-318625-hf7fgtnp 88 6 binding bind VBG cord-318625-hf7fgtnp 88 7 affinities affinity NNS cord-318625-hf7fgtnp 88 8 for for IN cord-318625-hf7fgtnp 88 9 MHC MHC NNP cord-318625-hf7fgtnp 88 10 - - HYPH cord-318625-hf7fgtnp 88 11 II II NNP cord-318625-hf7fgtnp 88 12 T T NNP cord-318625-hf7fgtnp 88 13 - - HYPH cord-318625-hf7fgtnp 88 14 cell cell NN cord-318625-hf7fgtnp 88 15 epitopes epitope NNS cord-318625-hf7fgtnp 88 16 are be VBP cord-318625-hf7fgtnp 88 17 given give VBN cord-318625-hf7fgtnp 88 18 in in IN cord-318625-hf7fgtnp 88 19 Table Table NNP cord-318625-hf7fgtnp 88 20 4 4 CD cord-318625-hf7fgtnp 88 21 . . . cord-318625-hf7fgtnp 89 1 Regions region NNS cord-318625-hf7fgtnp 89 2 from from IN cord-318625-hf7fgtnp 89 3 our -PRON- PRP$ cord-318625-hf7fgtnp 89 4 selected select VBN cord-318625-hf7fgtnp 89 5 peptides peptide NNS cord-318625-hf7fgtnp 89 6 are be VBP cord-318625-hf7fgtnp 89 7 highlighted highlight VBN cord-318625-hf7fgtnp 89 8 in in IN cord-318625-hf7fgtnp 89 9 red red NN cord-318625-hf7fgtnp 89 10 . . . cord-318625-hf7fgtnp 90 1 The the DT cord-318625-hf7fgtnp 90 2 epitopes epitope NNS cord-318625-hf7fgtnp 90 3 with with IN cord-318625-hf7fgtnp 90 4 rank rank NN cord-318625-hf7fgtnp 90 5 < < XX cord-318625-hf7fgtnp 90 6 1 1 CD cord-318625-hf7fgtnp 90 7 % % NN cord-318625-hf7fgtnp 90 8 for for IN cord-318625-hf7fgtnp 90 9 very very RB cord-318625-hf7fgtnp 90 10 high high JJ cord-318625-hf7fgtnp 90 11 binding bind VBG cord-318625-hf7fgtnp 90 12 affinity affinity NN cord-318625-hf7fgtnp 90 13 were be VBD cord-318625-hf7fgtnp 90 14 selected select VBN cord-318625-hf7fgtnp 90 15 . . . cord-318625-hf7fgtnp 91 1 We -PRON- PRP cord-318625-hf7fgtnp 91 2 also also RB cord-318625-hf7fgtnp 91 3 observed observe VBD cord-318625-hf7fgtnp 91 4 that that IN cord-318625-hf7fgtnp 91 5 some some DT cord-318625-hf7fgtnp 91 6 of of IN cord-318625-hf7fgtnp 91 7 the the DT cord-318625-hf7fgtnp 91 8 peptides peptide NNS cord-318625-hf7fgtnp 91 9 we -PRON- PRP cord-318625-hf7fgtnp 91 10 identified identify VBD cord-318625-hf7fgtnp 91 11 as as IN cord-318625-hf7fgtnp 91 12 potential potential JJ cord-318625-hf7fgtnp 91 13 B b NN cord-318625-hf7fgtnp 91 14 - - HYPH cord-318625-hf7fgtnp 91 15 cell cell NN cord-318625-hf7fgtnp 91 16 epitopes epitope NNS cord-318625-hf7fgtnp 91 17 were be VBD cord-318625-hf7fgtnp 91 18 present present JJ cord-318625-hf7fgtnp 91 19 as as IN cord-318625-hf7fgtnp 91 20 T t NN cord-318625-hf7fgtnp 91 21 - - HYPH cord-318625-hf7fgtnp 91 22 cell cell NN cord-318625-hf7fgtnp 91 23 epitopes epitope NNS cord-318625-hf7fgtnp 91 24 with with IN cord-318625-hf7fgtnp 91 25 good good JJ cord-318625-hf7fgtnp 91 26 binding bind VBG cord-318625-hf7fgtnp 91 27 affinities affinity NNS cord-318625-hf7fgtnp 91 28 . . . cord-318625-hf7fgtnp 92 1 Overall overall RB cord-318625-hf7fgtnp 92 2 , , , cord-318625-hf7fgtnp 92 3 it -PRON- PRP cord-318625-hf7fgtnp 92 4 was be VBD cord-318625-hf7fgtnp 92 5 found find VBN cord-318625-hf7fgtnp 92 6 that that IN cord-318625-hf7fgtnp 92 7 the the DT cord-318625-hf7fgtnp 92 8 regions region NNS cord-318625-hf7fgtnp 92 9 identified identify VBN cord-318625-hf7fgtnp 92 10 in in IN cord-318625-hf7fgtnp 92 11 Table Table NNP cord-318625-hf7fgtnp 92 12 1 1 CD cord-318625-hf7fgtnp 92 13 not not RB cord-318625-hf7fgtnp 92 14 only only RB cord-318625-hf7fgtnp 92 15 had have VBD cord-318625-hf7fgtnp 92 16 good good JJ cord-318625-hf7fgtnp 92 17 B b NN cord-318625-hf7fgtnp 92 18 - - HYPH cord-318625-hf7fgtnp 92 19 cell cell NN cord-318625-hf7fgtnp 92 20 and and CC cord-318625-hf7fgtnp 92 21 T t NN cord-318625-hf7fgtnp 92 22 - - HYPH cord-318625-hf7fgtnp 92 23 cell cell NN cord-318625-hf7fgtnp 92 24 affinities affinity NNS cord-318625-hf7fgtnp 92 25 , , , cord-318625-hf7fgtnp 92 26 but but CC cord-318625-hf7fgtnp 92 27 the the DT cord-318625-hf7fgtnp 92 28 majority majority NN cord-318625-hf7fgtnp 92 29 of of IN cord-318625-hf7fgtnp 92 30 them -PRON- PRP cord-318625-hf7fgtnp 92 31 had have VBD cord-318625-hf7fgtnp 92 32 also also RB cord-318625-hf7fgtnp 92 33 overlapped overlap VBN cord-318625-hf7fgtnp 92 34 with with IN cord-318625-hf7fgtnp 92 35 discontinuous discontinuous JJ cord-318625-hf7fgtnp 92 36 epitopes epitope NNS cord-318625-hf7fgtnp 92 37 ( ( -LRB- cord-318625-hf7fgtnp 92 38 Table Table NNP cord-318625-hf7fgtnp 92 39 S1 S1 NNP cord-318625-hf7fgtnp 92 40 ) ) -RRB- cord-318625-hf7fgtnp 92 41 . . . cord-318625-hf7fgtnp 93 1 The the DT cord-318625-hf7fgtnp 93 2 peptide peptide NN cord-318625-hf7fgtnp 93 3 segments segment NNS cord-318625-hf7fgtnp 93 4 identified identify VBN cord-318625-hf7fgtnp 93 5 from from IN cord-318625-hf7fgtnp 93 6 the the DT cord-318625-hf7fgtnp 93 7 set set NN cord-318625-hf7fgtnp 93 8 of of IN cord-318625-hf7fgtnp 93 9 98 98 CD cord-318625-hf7fgtnp 93 10 sequences sequence NNS cord-318625-hf7fgtnp 93 11 of of IN cord-318625-hf7fgtnp 93 12 the the DT cord-318625-hf7fgtnp 93 13 J J NNP cord-318625-hf7fgtnp 93 14 o o NN cord-318625-hf7fgtnp 93 15 u u NN cord-318625-hf7fgtnp 93 16 r r NN cord-318625-hf7fgtnp 93 17 n n NN cord-318625-hf7fgtnp 93 18 a a DT cord-318625-hf7fgtnp 93 19 l l NN cord-318625-hf7fgtnp 93 20 P p NN cord-318625-hf7fgtnp 93 21 r r NN cord-318625-hf7fgtnp 93 22 e e NN cord-318625-hf7fgtnp 93 23 -p -p NN cord-318625-hf7fgtnp 94 1 r r NN cord-318625-hf7fgtnp 94 2 o o NN cord-318625-hf7fgtnp 94 3 o o NN cord-318625-hf7fgtnp 94 4 f f NN cord-318625-hf7fgtnp 94 5 SARS SARS NNP cord-318625-hf7fgtnp 94 6 - - HYPH cord-318625-hf7fgtnp 94 7 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 94 8 S S NNP cord-318625-hf7fgtnp 94 9 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 94 10 appear appear VBP cord-318625-hf7fgtnp 94 11 to to TO cord-318625-hf7fgtnp 94 12 hold hold VB cord-318625-hf7fgtnp 94 13 reasonable reasonable JJ cord-318625-hf7fgtnp 94 14 potential potential NN cord-318625-hf7fgtnp 94 15 to to TO cord-318625-hf7fgtnp 94 16 act act VB cord-318625-hf7fgtnp 94 17 as as IN cord-318625-hf7fgtnp 94 18 immunogens immunogen NNS cord-318625-hf7fgtnp 94 19 . . . cord-318625-hf7fgtnp 95 1 Peptide peptide NN cord-318625-hf7fgtnp 95 2 - - HYPH cord-318625-hf7fgtnp 95 3 based base VBN cord-318625-hf7fgtnp 95 4 diagnostics diagnostic NNS cord-318625-hf7fgtnp 95 5 and and CC cord-318625-hf7fgtnp 95 6 vaccines vaccine NNS cord-318625-hf7fgtnp 95 7 have have VBP cord-318625-hf7fgtnp 95 8 previously previously RB cord-318625-hf7fgtnp 95 9 been be VBN cord-318625-hf7fgtnp 95 10 proposed propose VBN cord-318625-hf7fgtnp 95 11 against against IN cord-318625-hf7fgtnp 95 12 virus virus NN cord-318625-hf7fgtnp 95 13 outbreaks outbreak NNS cord-318625-hf7fgtnp 95 14 ( ( -LRB- cord-318625-hf7fgtnp 95 15 Dey Dey NNP cord-318625-hf7fgtnp 95 16 et et FW cord-318625-hf7fgtnp 95 17 al al NNP cord-318625-hf7fgtnp 95 18 . . NNP cord-318625-hf7fgtnp 95 19 , , , cord-318625-hf7fgtnp 95 20 2017 2017 CD cord-318625-hf7fgtnp 95 21 ; ; : cord-318625-hf7fgtnp 95 22 Ichihashi Ichihashi NNP cord-318625-hf7fgtnp 95 23 et et NNP cord-318625-hf7fgtnp 95 24 al al NNP cord-318625-hf7fgtnp 95 25 . . NNP cord-318625-hf7fgtnp 95 26 , , , cord-318625-hf7fgtnp 95 27 2011 2011 CD cord-318625-hf7fgtnp 95 28 ; ; : cord-318625-hf7fgtnp 95 29 Navalkar Navalkar NNP cord-318625-hf7fgtnp 95 30 et et NNP cord-318625-hf7fgtnp 95 31 al al NNP cord-318625-hf7fgtnp 95 32 . . NNP cord-318625-hf7fgtnp 95 33 , , , cord-318625-hf7fgtnp 95 34 2015 2015 CD cord-318625-hf7fgtnp 95 35 ; ; : cord-318625-hf7fgtnp 95 36 Oany Oany NNP cord-318625-hf7fgtnp 95 37 et et NNP cord-318625-hf7fgtnp 95 38 al al NNP cord-318625-hf7fgtnp 95 39 . . NNP cord-318625-hf7fgtnp 95 40 , , , cord-318625-hf7fgtnp 95 41 2014 2014 CD cord-318625-hf7fgtnp 95 42 ; ; : cord-318625-hf7fgtnp 95 43 Zhao Zhao NNP cord-318625-hf7fgtnp 95 44 et et NNP cord-318625-hf7fgtnp 95 45 al al NNP cord-318625-hf7fgtnp 95 46 . . NNP cord-318625-hf7fgtnp 95 47 , , , cord-318625-hf7fgtnp 95 48 2009 2009 CD cord-318625-hf7fgtnp 95 49 ) ) -RRB- cord-318625-hf7fgtnp 95 50 . . . cord-318625-hf7fgtnp 96 1 The the DT cord-318625-hf7fgtnp 96 2 availability availability NN cord-318625-hf7fgtnp 96 3 of of IN cord-318625-hf7fgtnp 96 4 a a DT cord-318625-hf7fgtnp 96 5 3D 3d JJ cord-318625-hf7fgtnp 96 6 structure structure NN cord-318625-hf7fgtnp 96 7 ( ( -LRB- cord-318625-hf7fgtnp 96 8 6VSB 6VSB NNP cord-318625-hf7fgtnp 96 9 ) ) -RRB- cord-318625-hf7fgtnp 96 10 of of IN cord-318625-hf7fgtnp 96 11 the the DT cord-318625-hf7fgtnp 96 12 SARS SARS NNP cord-318625-hf7fgtnp 96 13 - - HYPH cord-318625-hf7fgtnp 96 14 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 96 15 S S NNP cord-318625-hf7fgtnp 96 16 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 96 17 provided provide VBD cord-318625-hf7fgtnp 96 18 an an DT cord-318625-hf7fgtnp 96 19 opportunity opportunity NN cord-318625-hf7fgtnp 96 20 to to TO cord-318625-hf7fgtnp 96 21 inspect inspect VB cord-318625-hf7fgtnp 96 22 the the DT cord-318625-hf7fgtnp 96 23 predicted predict VBN cord-318625-hf7fgtnp 96 24 peptides peptide NNS cord-318625-hf7fgtnp 96 25 . . . cord-318625-hf7fgtnp 97 1 Placement placement NN cord-318625-hf7fgtnp 97 2 of of IN cord-318625-hf7fgtnp 97 3 the the DT cord-318625-hf7fgtnp 97 4 peptide peptide NN cord-318625-hf7fgtnp 97 5 segments segment NNS cord-318625-hf7fgtnp 97 6 identified identify VBN cord-318625-hf7fgtnp 97 7 by by IN cord-318625-hf7fgtnp 97 8 ASA ASA NNP cord-318625-hf7fgtnp 97 9 and and CC cord-318625-hf7fgtnp 97 10 conserved conserved JJ cord-318625-hf7fgtnp 97 11 sequence sequence NN cord-318625-hf7fgtnp 97 12 analysis analysis NN cord-318625-hf7fgtnp 97 13 on on IN cord-318625-hf7fgtnp 97 14 the the DT cord-318625-hf7fgtnp 97 15 S S NNP cord-318625-hf7fgtnp 97 16 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 97 17 showed show VBD cord-318625-hf7fgtnp 97 18 that that IN cord-318625-hf7fgtnp 97 19 20 20 CD cord-318625-hf7fgtnp 97 20 of of IN cord-318625-hf7fgtnp 97 21 the the DT cord-318625-hf7fgtnp 97 22 regions region NNS cord-318625-hf7fgtnp 97 23 we -PRON- PRP cord-318625-hf7fgtnp 97 24 identified identify VBD cord-318625-hf7fgtnp 97 25 lie lie NN cord-318625-hf7fgtnp 97 26 on on IN cord-318625-hf7fgtnp 97 27 the the DT cord-318625-hf7fgtnp 97 28 surface surface NN cord-318625-hf7fgtnp 97 29 ( ( -LRB- cord-318625-hf7fgtnp 97 30 Figure figure NN cord-318625-hf7fgtnp 97 31 3 3 CD cord-318625-hf7fgtnp 97 32 ) ) -RRB- cord-318625-hf7fgtnp 97 33 . . . cord-318625-hf7fgtnp 98 1 In in IN cord-318625-hf7fgtnp 98 2 order order NN cord-318625-hf7fgtnp 98 3 to to TO cord-318625-hf7fgtnp 98 4 limit limit VB cord-318625-hf7fgtnp 98 5 recognition recognition NN cord-318625-hf7fgtnp 98 6 and and CC cord-318625-hf7fgtnp 98 7 evade evade VB cord-318625-hf7fgtnp 98 8 the the DT cord-318625-hf7fgtnp 98 9 immune immune JJ cord-318625-hf7fgtnp 98 10 response response NN cord-318625-hf7fgtnp 98 11 of of IN cord-318625-hf7fgtnp 98 12 the the DT cord-318625-hf7fgtnp 98 13 host host NN cord-318625-hf7fgtnp 98 14 , , , cord-318625-hf7fgtnp 98 15 coronaviruses coronaviruse NNS cord-318625-hf7fgtnp 98 16 use use VBP cord-318625-hf7fgtnp 98 17 conformational conformational JJ cord-318625-hf7fgtnp 98 18 masking masking NN cord-318625-hf7fgtnp 98 19 and and CC cord-318625-hf7fgtnp 98 20 glycan glycan NN cord-318625-hf7fgtnp 98 21 shielding shielding NN cord-318625-hf7fgtnp 98 22 Xiong Xiong NNP cord-318625-hf7fgtnp 98 23 et et NNP cord-318625-hf7fgtnp 98 24 al al NNP cord-318625-hf7fgtnp 98 25 . . NNP cord-318625-hf7fgtnp 98 26 , , , cord-318625-hf7fgtnp 98 27 2018 2018 CD cord-318625-hf7fgtnp 98 28 ) ) -RRB- cord-318625-hf7fgtnp 98 29 . . . cord-318625-hf7fgtnp 99 1 SARS SARS NNP cord-318625-hf7fgtnp 99 2 - - HYPH cord-318625-hf7fgtnp 99 3 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 99 4 S S NNP cord-318625-hf7fgtnp 99 5 trimer trimer NN cord-318625-hf7fgtnp 99 6 also also RB cord-318625-hf7fgtnp 99 7 exists exist VBZ cord-318625-hf7fgtnp 99 8 in in IN cord-318625-hf7fgtnp 99 9 multiple multiple JJ cord-318625-hf7fgtnp 99 10 distinct distinct JJ cord-318625-hf7fgtnp 99 11 conformational conformational JJ cord-318625-hf7fgtnp 99 12 states state NNS cord-318625-hf7fgtnp 99 13 , , , cord-318625-hf7fgtnp 99 14 which which WDT cord-318625-hf7fgtnp 99 15 is be VBZ cord-318625-hf7fgtnp 99 16 necessary necessary JJ cord-318625-hf7fgtnp 99 17 for for IN cord-318625-hf7fgtnp 99 18 receptor receptor NN cord-318625-hf7fgtnp 99 19 engagement engagement NN cord-318625-hf7fgtnp 99 20 , , , cord-318625-hf7fgtnp 99 21 leading lead VBG cord-318625-hf7fgtnp 99 22 to to IN cord-318625-hf7fgtnp 99 23 the the DT cord-318625-hf7fgtnp 99 24 initiation initiation NN cord-318625-hf7fgtnp 99 25 of of IN cord-318625-hf7fgtnp 99 26 fusogenic fusogenic JJ cord-318625-hf7fgtnp 99 27 conformational conformational JJ cord-318625-hf7fgtnp 99 28 changes change NNS cord-318625-hf7fgtnp 99 29 ( ( -LRB- cord-318625-hf7fgtnp 99 30 Walls Walls NNPS cord-318625-hf7fgtnp 99 31 et et NNP cord-318625-hf7fgtnp 99 32 al al NNP cord-318625-hf7fgtnp 99 33 . . NNP cord-318625-hf7fgtnp 99 34 , , , cord-318625-hf7fgtnp 99 35 2020 2020 CD cord-318625-hf7fgtnp 99 36 ) ) -RRB- cord-318625-hf7fgtnp 99 37 . . . cord-318625-hf7fgtnp 100 1 The the DT cord-318625-hf7fgtnp 100 2 considerable considerable JJ cord-318625-hf7fgtnp 100 3 number number NN cord-318625-hf7fgtnp 100 4 of of IN cord-318625-hf7fgtnp 100 5 peptides peptide NNS cord-318625-hf7fgtnp 100 6 at at IN cord-318625-hf7fgtnp 100 7 the the DT cord-318625-hf7fgtnp 100 8 surface surface NN cord-318625-hf7fgtnp 100 9 region region NN cord-318625-hf7fgtnp 100 10 of of IN cord-318625-hf7fgtnp 100 11 the the DT cord-318625-hf7fgtnp 100 12 S S NNP cord-318625-hf7fgtnp 100 13 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 100 14 allows allow VBZ cord-318625-hf7fgtnp 100 15 for for IN cord-318625-hf7fgtnp 100 16 the the DT cord-318625-hf7fgtnp 100 17 potential potential JJ cord-318625-hf7fgtnp 100 18 use use NN cord-318625-hf7fgtnp 100 19 of of IN cord-318625-hf7fgtnp 100 20 those those DT cord-318625-hf7fgtnp 100 21 peptide peptide JJ cord-318625-hf7fgtnp 100 22 regions region NNS cord-318625-hf7fgtnp 100 23 as as IN cord-318625-hf7fgtnp 100 24 immunogens immunogen NNS cord-318625-hf7fgtnp 100 25 . . . cord-318625-hf7fgtnp 101 1 Binding bind VBG cord-318625-hf7fgtnp 101 2 to to IN cord-318625-hf7fgtnp 101 3 the the DT cord-318625-hf7fgtnp 101 4 ACE2 ACE2 NNP cord-318625-hf7fgtnp 101 5 receptor receptor NN cord-318625-hf7fgtnp 101 6 is be VBZ cord-318625-hf7fgtnp 101 7 a a DT cord-318625-hf7fgtnp 101 8 critical critical JJ cord-318625-hf7fgtnp 101 9 initial initial JJ cord-318625-hf7fgtnp 101 10 step step NN cord-318625-hf7fgtnp 101 11 for for IN cord-318625-hf7fgtnp 101 12 the the DT cord-318625-hf7fgtnp 101 13 SARS SARS NNP cord-318625-hf7fgtnp 101 14 - - HYPH cord-318625-hf7fgtnp 101 15 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 101 16 in in IN cord-318625-hf7fgtnp 101 17 entering enter VBG cord-318625-hf7fgtnp 101 18 target target NN cord-318625-hf7fgtnp 101 19 cells cell NNS cord-318625-hf7fgtnp 101 20 . . . cord-318625-hf7fgtnp 102 1 Recent recent JJ cord-318625-hf7fgtnp 102 2 studies study NNS cord-318625-hf7fgtnp 102 3 have have VBP cord-318625-hf7fgtnp 102 4 also also RB cord-318625-hf7fgtnp 102 5 pointed point VBN cord-318625-hf7fgtnp 102 6 out out RP cord-318625-hf7fgtnp 102 7 the the DT cord-318625-hf7fgtnp 102 8 vital vital JJ cord-318625-hf7fgtnp 102 9 role role NN cord-318625-hf7fgtnp 102 10 of of IN cord-318625-hf7fgtnp 102 11 ACE2 ACE2 NNP cord-318625-hf7fgtnp 102 12 in in IN cord-318625-hf7fgtnp 102 13 mediating mediate VBG cord-318625-hf7fgtnp 102 14 the the DT cord-318625-hf7fgtnp 102 15 entry entry NN cord-318625-hf7fgtnp 102 16 of of IN cord-318625-hf7fgtnp 102 17 SARS SARS NNP cord-318625-hf7fgtnp 102 18 - - HYPH cord-318625-hf7fgtnp 102 19 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 102 20 ( ( -LRB- cord-318625-hf7fgtnp 102 21 Hoffmann Hoffmann NNP cord-318625-hf7fgtnp 102 22 et et NNP cord-318625-hf7fgtnp 102 23 al al NNP cord-318625-hf7fgtnp 102 24 . . NNP cord-318625-hf7fgtnp 102 25 , , , cord-318625-hf7fgtnp 102 26 2020 2020 CD cord-318625-hf7fgtnp 102 27 ) ) -RRB- cord-318625-hf7fgtnp 102 28 . . . cord-318625-hf7fgtnp 103 1 Receptor receptor NN cord-318625-hf7fgtnp 103 2 binding binding NN cord-318625-hf7fgtnp 103 3 motif motif NN cord-318625-hf7fgtnp 103 4 ( ( -LRB- cord-318625-hf7fgtnp 103 5 RBM RBM NNP cord-318625-hf7fgtnp 103 6 ) ) -RRB- cord-318625-hf7fgtnp 103 7 is be VBZ cord-318625-hf7fgtnp 103 8 part part NN cord-318625-hf7fgtnp 103 9 of of IN cord-318625-hf7fgtnp 103 10 the the DT cord-318625-hf7fgtnp 103 11 receptor receptor NN cord-318625-hf7fgtnp 103 12 - - HYPH cord-318625-hf7fgtnp 103 13 binding bind VBG cord-318625-hf7fgtnp 103 14 domain domain NN cord-318625-hf7fgtnp 103 15 ( ( -LRB- cord-318625-hf7fgtnp 103 16 RBD RBD NNP cord-318625-hf7fgtnp 103 17 ) ) -RRB- cord-318625-hf7fgtnp 103 18 of of IN cord-318625-hf7fgtnp 103 19 SARS SARS NNP cord-318625-hf7fgtnp 103 20 - - HYPH cord-318625-hf7fgtnp 103 21 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 103 22 , , , cord-318625-hf7fgtnp 103 23 which which WDT cord-318625-hf7fgtnp 103 24 contains contain VBZ cord-318625-hf7fgtnp 103 25 most most JJS cord-318625-hf7fgtnp 103 26 of of IN cord-318625-hf7fgtnp 103 27 the the DT cord-318625-hf7fgtnp 103 28 contacting contact VBG cord-318625-hf7fgtnp 103 29 residue residue NN cord-318625-hf7fgtnp 103 30 for for IN cord-318625-hf7fgtnp 103 31 ACE-2 ACE-2 NNP cord-318625-hf7fgtnp 103 32 binding bind VBG cord-318625-hf7fgtnp 104 1 ( ( -LRB- cord-318625-hf7fgtnp 104 2 Lan Lan NNP cord-318625-hf7fgtnp 104 3 et et FW cord-318625-hf7fgtnp 104 4 al al NNP cord-318625-hf7fgtnp 104 5 . . NNP cord-318625-hf7fgtnp 104 6 , , , cord-318625-hf7fgtnp 104 7 2020 2020 CD cord-318625-hf7fgtnp 104 8 ) ) -RRB- cord-318625-hf7fgtnp 104 9 . . . cord-318625-hf7fgtnp 105 1 It -PRON- PRP cord-318625-hf7fgtnp 105 2 was be VBD cord-318625-hf7fgtnp 105 3 observed observe VBN cord-318625-hf7fgtnp 105 4 that that IN cord-318625-hf7fgtnp 105 5 some some DT cord-318625-hf7fgtnp 105 6 of of IN cord-318625-hf7fgtnp 105 7 our -PRON- PRP$ cord-318625-hf7fgtnp 105 8 identified identify VBN cord-318625-hf7fgtnp 105 9 peptides peptide NNS cord-318625-hf7fgtnp 105 10 from from IN cord-318625-hf7fgtnp 105 11 Table table NN cord-318625-hf7fgtnp 105 12 1 1 CD cord-318625-hf7fgtnp 105 13 ( ( -LRB- cord-318625-hf7fgtnp 105 14 peptide peptide JJ cord-318625-hf7fgtnp 105 15 no no NN cord-318625-hf7fgtnp 105 16 . . NN cord-318625-hf7fgtnp 105 17 7 7 CD cord-318625-hf7fgtnp 105 18 - - SYM cord-318625-hf7fgtnp 105 19 12 12 CD cord-318625-hf7fgtnp 105 20 ) ) -RRB- cord-318625-hf7fgtnp 105 21 fall fall VB cord-318625-hf7fgtnp 105 22 in in IN cord-318625-hf7fgtnp 105 23 the the DT cord-318625-hf7fgtnp 105 24 regions region NNS cord-318625-hf7fgtnp 105 25 of of IN cord-318625-hf7fgtnp 105 26 RBD RBD NNP cord-318625-hf7fgtnp 105 27 ( ( -LRB- cord-318625-hf7fgtnp 105 28 amino amino NN cord-318625-hf7fgtnp 105 29 acid acid NN cord-318625-hf7fgtnp 105 30 no no NN cord-318625-hf7fgtnp 105 31 . . . cord-318625-hf7fgtnp 106 1 319 319 CD cord-318625-hf7fgtnp 106 2 - - SYM cord-318625-hf7fgtnp 106 3 540 540 CD cord-318625-hf7fgtnp 106 4 ) ) -RRB- cord-318625-hf7fgtnp 107 1 and and CC cord-318625-hf7fgtnp 107 2 RBM RBM NNP cord-318625-hf7fgtnp 107 3 ( ( -LRB- cord-318625-hf7fgtnp 107 4 amino amino NN cord-318625-hf7fgtnp 107 5 acid acid NN cord-318625-hf7fgtnp 107 6 no no NN cord-318625-hf7fgtnp 107 7 . . NN cord-318625-hf7fgtnp 107 8 438 438 CD cord-318625-hf7fgtnp 107 9 - - SYM cord-318625-hf7fgtnp 107 10 506 506 CD cord-318625-hf7fgtnp 107 11 ) ) -RRB- cord-318625-hf7fgtnp 107 12 , , , cord-318625-hf7fgtnp 107 13 which which WDT cord-318625-hf7fgtnp 107 14 makes make VBZ cord-318625-hf7fgtnp 107 15 them -PRON- PRP cord-318625-hf7fgtnp 107 16 potential potential JJ cord-318625-hf7fgtnp 107 17 peptide peptide JJ cord-318625-hf7fgtnp 107 18 regions region NNS cord-318625-hf7fgtnp 107 19 to to TO cord-318625-hf7fgtnp 107 20 be be VB cord-318625-hf7fgtnp 107 21 used use VBN cord-318625-hf7fgtnp 107 22 . . . cord-318625-hf7fgtnp 108 1 The the DT cord-318625-hf7fgtnp 108 2 emergence emergence NN cord-318625-hf7fgtnp 108 3 of of IN cord-318625-hf7fgtnp 108 4 new new JJ cord-318625-hf7fgtnp 108 5 viral viral JJ cord-318625-hf7fgtnp 108 6 diseases disease NNS cord-318625-hf7fgtnp 108 7 like like IN cord-318625-hf7fgtnp 108 8 SARS SARS NNP cord-318625-hf7fgtnp 108 9 - - HYPH cord-318625-hf7fgtnp 108 10 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 108 11 represents represent VBZ cord-318625-hf7fgtnp 108 12 a a DT cord-318625-hf7fgtnp 108 13 substantial substantial JJ cord-318625-hf7fgtnp 108 14 global global JJ cord-318625-hf7fgtnp 108 15 disease disease NN cord-318625-hf7fgtnp 108 16 burden burden NN cord-318625-hf7fgtnp 108 17 . . . cord-318625-hf7fgtnp 109 1 Over over IN cord-318625-hf7fgtnp 109 2 the the DT cord-318625-hf7fgtnp 109 3 past past JJ cord-318625-hf7fgtnp 109 4 few few JJ cord-318625-hf7fgtnp 109 5 months month NNS cord-318625-hf7fgtnp 109 6 , , , cord-318625-hf7fgtnp 109 7 there there EX cord-318625-hf7fgtnp 109 8 have have VBP cord-318625-hf7fgtnp 109 9 been be VBN cord-318625-hf7fgtnp 109 10 increased increase VBN cord-318625-hf7fgtnp 109 11 research research NN cord-318625-hf7fgtnp 109 12 efforts effort NNS cord-318625-hf7fgtnp 109 13 for for IN cord-318625-hf7fgtnp 109 14 the the DT cord-318625-hf7fgtnp 109 15 design design NN cord-318625-hf7fgtnp 109 16 and and CC cord-318625-hf7fgtnp 109 17 development development NN cord-318625-hf7fgtnp 109 18 of of IN cord-318625-hf7fgtnp 109 19 diagnostics diagnostic NNS cord-318625-hf7fgtnp 109 20 and and CC cord-318625-hf7fgtnp 109 21 vaccines vaccine NNS cord-318625-hf7fgtnp 109 22 for for IN cord-318625-hf7fgtnp 109 23 SARS SARS NNP cord-318625-hf7fgtnp 109 24 - - HYPH cord-318625-hf7fgtnp 109 25 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 109 26 . . . cord-318625-hf7fgtnp 110 1 Some some DT cord-318625-hf7fgtnp 110 2 related related JJ cord-318625-hf7fgtnp 110 3 analyses analysis NNS cord-318625-hf7fgtnp 110 4 have have VBP cord-318625-hf7fgtnp 110 5 been be VBN cord-318625-hf7fgtnp 110 6 reported report VBN cord-318625-hf7fgtnp 110 7 in in IN cord-318625-hf7fgtnp 110 8 distinct distinct JJ cord-318625-hf7fgtnp 110 9 , , , cord-318625-hf7fgtnp 110 10 parallel parallel JJ cord-318625-hf7fgtnp 110 11 studies study NNS cord-318625-hf7fgtnp 110 12 ( ( -LRB- cord-318625-hf7fgtnp 110 13 Baruah Baruah NNP cord-318625-hf7fgtnp 110 14 and and CC cord-318625-hf7fgtnp 110 15 Bose Bose NNP cord-318625-hf7fgtnp 110 16 , , , cord-318625-hf7fgtnp 110 17 2020 2020 CD cord-318625-hf7fgtnp 110 18 ; ; : cord-318625-hf7fgtnp 110 19 Bhattacharya Bhattacharya NNP cord-318625-hf7fgtnp 110 20 et et NNP cord-318625-hf7fgtnp 110 21 al al NNP cord-318625-hf7fgtnp 110 22 . . NNP cord-318625-hf7fgtnp 110 23 , , , cord-318625-hf7fgtnp 110 24 2020 2020 CD cord-318625-hf7fgtnp 110 25 ; ; : cord-318625-hf7fgtnp 110 26 Grifoni Grifoni NNP cord-318625-hf7fgtnp 110 27 et et FW cord-318625-hf7fgtnp 110 28 al al NNP cord-318625-hf7fgtnp 110 29 . . NNP cord-318625-hf7fgtnp 110 30 , , , cord-318625-hf7fgtnp 110 31 2020 2020 CD cord-318625-hf7fgtnp 110 32 ) ) -RRB- cord-318625-hf7fgtnp 110 33 . . . cord-318625-hf7fgtnp 111 1 Our -PRON- PRP$ cord-318625-hf7fgtnp 111 2 study study NN cord-318625-hf7fgtnp 111 3 leverages leverage VBZ cord-318625-hf7fgtnp 111 4 the the DT cord-318625-hf7fgtnp 111 5 available available JJ cord-318625-hf7fgtnp 111 6 resources resource NNS cord-318625-hf7fgtnp 111 7 and and CC cord-318625-hf7fgtnp 111 8 computational computational JJ cord-318625-hf7fgtnp 111 9 J j NN cord-318625-hf7fgtnp 111 10 o o NN cord-318625-hf7fgtnp 111 11 u u NN cord-318625-hf7fgtnp 111 12 r r NN cord-318625-hf7fgtnp 111 13 n n NN cord-318625-hf7fgtnp 111 14 a a DT cord-318625-hf7fgtnp 111 15 l l NN cord-318625-hf7fgtnp 111 16 P p NN cord-318625-hf7fgtnp 111 17 r r NN cord-318625-hf7fgtnp 111 18 e e NN cord-318625-hf7fgtnp 112 1 -p -p : cord-318625-hf7fgtnp 113 1 r r NN cord-318625-hf7fgtnp 113 2 o o NN cord-318625-hf7fgtnp 113 3 o o NN cord-318625-hf7fgtnp 113 4 f f NN cord-318625-hf7fgtnp 113 5 methods method NNS cord-318625-hf7fgtnp 113 6 and and CC cord-318625-hf7fgtnp 113 7 adds add VBZ cord-318625-hf7fgtnp 113 8 to to IN cord-318625-hf7fgtnp 113 9 the the DT cord-318625-hf7fgtnp 113 10 ongoing ongoing JJ cord-318625-hf7fgtnp 113 11 research research NN cord-318625-hf7fgtnp 113 12 focused focus VBD cord-318625-hf7fgtnp 113 13 on on IN cord-318625-hf7fgtnp 113 14 the the DT cord-318625-hf7fgtnp 113 15 development development NN cord-318625-hf7fgtnp 113 16 of of IN cord-318625-hf7fgtnp 113 17 diagnostics diagnostic NNS cord-318625-hf7fgtnp 113 18 and and CC cord-318625-hf7fgtnp 113 19 vaccines vaccine NNS cord-318625-hf7fgtnp 113 20 against against IN cord-318625-hf7fgtnp 113 21 SARS SARS NNP cord-318625-hf7fgtnp 113 22 - - HYPH cord-318625-hf7fgtnp 113 23 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 113 24 . . . cord-318625-hf7fgtnp 114 1 Other other JJ cord-318625-hf7fgtnp 114 2 than than IN cord-318625-hf7fgtnp 114 3 already already RB cord-318625-hf7fgtnp 114 4 existing exist VBG cord-318625-hf7fgtnp 114 5 ones one NNS cord-318625-hf7fgtnp 114 6 , , , cord-318625-hf7fgtnp 114 7 we -PRON- PRP cord-318625-hf7fgtnp 114 8 have have VBP cord-318625-hf7fgtnp 114 9 identified identify VBN cord-318625-hf7fgtnp 114 10 a a DT cord-318625-hf7fgtnp 114 11 further further JJ cord-318625-hf7fgtnp 114 12 number number NN cord-318625-hf7fgtnp 114 13 of of IN cord-318625-hf7fgtnp 114 14 peptides peptide NNS cord-318625-hf7fgtnp 114 15 , , , cord-318625-hf7fgtnp 114 16 which which WDT cord-318625-hf7fgtnp 114 17 adds add VBZ cord-318625-hf7fgtnp 114 18 to to IN cord-318625-hf7fgtnp 114 19 the the DT cord-318625-hf7fgtnp 114 20 library library NN cord-318625-hf7fgtnp 114 21 of of IN cord-318625-hf7fgtnp 114 22 peptides peptide NNS cord-318625-hf7fgtnp 114 23 that that WDT cord-318625-hf7fgtnp 114 24 are be VBP cord-318625-hf7fgtnp 114 25 likely likely JJ cord-318625-hf7fgtnp 114 26 to to TO cord-318625-hf7fgtnp 114 27 be be VB cord-318625-hf7fgtnp 114 28 recognized recognize VBN cord-318625-hf7fgtnp 114 29 by by IN cord-318625-hf7fgtnp 114 30 human human JJ cord-318625-hf7fgtnp 114 31 immune immune JJ cord-318625-hf7fgtnp 114 32 responses response NNS cord-318625-hf7fgtnp 114 33 . . . cord-318625-hf7fgtnp 115 1 Facilitated facilitate VBN cord-318625-hf7fgtnp 115 2 by by IN cord-318625-hf7fgtnp 115 3 high high JJ cord-318625-hf7fgtnp 115 4 mutation mutation NN cord-318625-hf7fgtnp 115 5 rates rate NNS cord-318625-hf7fgtnp 115 6 , , , cord-318625-hf7fgtnp 115 7 traditional traditional JJ cord-318625-hf7fgtnp 115 8 vaccines vaccine NNS cord-318625-hf7fgtnp 115 9 based base VBN cord-318625-hf7fgtnp 115 10 on on IN cord-318625-hf7fgtnp 115 11 antibody antibody NN cord-318625-hf7fgtnp 115 12 - - HYPH cord-318625-hf7fgtnp 115 13 mediated mediate VBN cord-318625-hf7fgtnp 115 14 protection protection NN cord-318625-hf7fgtnp 115 15 are be VBP cord-318625-hf7fgtnp 115 16 often often RB cord-318625-hf7fgtnp 115 17 poor poor JJ cord-318625-hf7fgtnp 115 18 inducers inducer NNS cord-318625-hf7fgtnp 115 19 of of IN cord-318625-hf7fgtnp 115 20 T t NN cord-318625-hf7fgtnp 115 21 - - HYPH cord-318625-hf7fgtnp 115 22 cell cell NN cord-318625-hf7fgtnp 115 23 responses response NNS cord-318625-hf7fgtnp 115 24 and and CC cord-318625-hf7fgtnp 115 25 can can MD cord-318625-hf7fgtnp 115 26 have have VB cord-318625-hf7fgtnp 115 27 limited limit VBN cord-318625-hf7fgtnp 115 28 success success NN cord-318625-hf7fgtnp 116 1 ( ( -LRB- cord-318625-hf7fgtnp 116 2 Rosendahl Rosendahl NNP cord-318625-hf7fgtnp 116 3 Huber Huber NNP cord-318625-hf7fgtnp 116 4 et et NNP cord-318625-hf7fgtnp 116 5 al al NNP cord-318625-hf7fgtnp 116 6 . . . cord-318625-hf7fgtnp 117 1 , , , cord-318625-hf7fgtnp 117 2 2014 2014 CD cord-318625-hf7fgtnp 117 3 ) ) -RRB- cord-318625-hf7fgtnp 117 4 . . . cord-318625-hf7fgtnp 118 1 Peptide peptide NN cord-318625-hf7fgtnp 118 2 - - HYPH cord-318625-hf7fgtnp 118 3 based base VBN cord-318625-hf7fgtnp 118 4 sensitive sensitive JJ cord-318625-hf7fgtnp 118 5 and and CC cord-318625-hf7fgtnp 118 6 rapid rapid JJ cord-318625-hf7fgtnp 118 7 diagnostic diagnostic JJ cord-318625-hf7fgtnp 118 8 kits kit NNS cord-318625-hf7fgtnp 118 9 are be VBP cord-318625-hf7fgtnp 118 10 considered consider VBN cord-318625-hf7fgtnp 118 11 a a DT cord-318625-hf7fgtnp 118 12 better well JJR cord-318625-hf7fgtnp 118 13 alternative alternative NN cord-318625-hf7fgtnp 118 14 to to IN cord-318625-hf7fgtnp 118 15 the the DT cord-318625-hf7fgtnp 118 16 conventional conventional JJ cord-318625-hf7fgtnp 118 17 serological serological JJ cord-318625-hf7fgtnp 118 18 tests test NNS cord-318625-hf7fgtnp 118 19 , , , cord-318625-hf7fgtnp 118 20 including include VBG cord-318625-hf7fgtnp 118 21 whole whole JJ cord-318625-hf7fgtnp 118 22 antigenic antigenic JJ cord-318625-hf7fgtnp 118 23 protein protein NN cord-318625-hf7fgtnp 118 24 ( ( -LRB- cord-318625-hf7fgtnp 118 25 Mohanraj Mohanraj NNP cord-318625-hf7fgtnp 118 26 et et NNP cord-318625-hf7fgtnp 118 27 al al NNP cord-318625-hf7fgtnp 118 28 . . NNP cord-318625-hf7fgtnp 118 29 , , , cord-318625-hf7fgtnp 118 30 2017 2017 CD cord-318625-hf7fgtnp 118 31 ) ) -RRB- cord-318625-hf7fgtnp 118 32 . . . cord-318625-hf7fgtnp 119 1 In in IN cord-318625-hf7fgtnp 119 2 our -PRON- PRP$ cord-318625-hf7fgtnp 119 3 study study NN cord-318625-hf7fgtnp 119 4 , , , cord-318625-hf7fgtnp 119 5 we -PRON- PRP cord-318625-hf7fgtnp 119 6 predicted predict VBD cord-318625-hf7fgtnp 119 7 both both DT cord-318625-hf7fgtnp 119 8 B b NN cord-318625-hf7fgtnp 119 9 - - HYPH cord-318625-hf7fgtnp 119 10 cell cell NN cord-318625-hf7fgtnp 119 11 and and CC cord-318625-hf7fgtnp 119 12 T t NN cord-318625-hf7fgtnp 119 13 - - HYPH cord-318625-hf7fgtnp 119 14 cell cell NN cord-318625-hf7fgtnp 119 15 epitopes epitope NNS cord-318625-hf7fgtnp 119 16 for for IN cord-318625-hf7fgtnp 119 17 conferring confer VBG cord-318625-hf7fgtnp 119 18 immunity immunity NN cord-318625-hf7fgtnp 119 19 in in IN cord-318625-hf7fgtnp 119 20 different different JJ cord-318625-hf7fgtnp 119 21 ways way NNS cord-318625-hf7fgtnp 119 22 . . . cord-318625-hf7fgtnp 120 1 We -PRON- PRP cord-318625-hf7fgtnp 120 2 speculate speculate VBP cord-318625-hf7fgtnp 120 3 that that IN cord-318625-hf7fgtnp 120 4 the the DT cord-318625-hf7fgtnp 120 5 identified identify VBN cord-318625-hf7fgtnp 120 6 epitopes epitope NNS cord-318625-hf7fgtnp 120 7 with with IN cord-318625-hf7fgtnp 120 8 considerably considerably RB cord-318625-hf7fgtnp 120 9 good good JJ cord-318625-hf7fgtnp 120 10 epitope epitope NN cord-318625-hf7fgtnp 120 11 binding bind VBG cord-318625-hf7fgtnp 120 12 efficiency efficiency NN cord-318625-hf7fgtnp 120 13 have have VBP cord-318625-hf7fgtnp 120 14 the the DT cord-318625-hf7fgtnp 120 15 potential potential NN cord-318625-hf7fgtnp 120 16 to to TO cord-318625-hf7fgtnp 120 17 be be VB cord-318625-hf7fgtnp 120 18 an an DT cord-318625-hf7fgtnp 120 19 immunodominant immunodominant JJ cord-318625-hf7fgtnp 120 20 peptide peptide NN cord-318625-hf7fgtnp 120 21 . . . cord-318625-hf7fgtnp 121 1 The the DT cord-318625-hf7fgtnp 121 2 study study NN cord-318625-hf7fgtnp 121 3 could could MD cord-318625-hf7fgtnp 121 4 help help VB cord-318625-hf7fgtnp 121 5 us -PRON- PRP cord-318625-hf7fgtnp 121 6 to to TO cord-318625-hf7fgtnp 121 7 use use VB cord-318625-hf7fgtnp 121 8 the the DT cord-318625-hf7fgtnp 121 9 predicted predict VBN cord-318625-hf7fgtnp 121 10 peptide peptide NN cord-318625-hf7fgtnp 121 11 as as IN cord-318625-hf7fgtnp 121 12 an an DT cord-318625-hf7fgtnp 121 13 immunogen immunogen NN cord-318625-hf7fgtnp 121 14 for for IN cord-318625-hf7fgtnp 121 15 the the DT cord-318625-hf7fgtnp 121 16 development development NN cord-318625-hf7fgtnp 121 17 of of IN cord-318625-hf7fgtnp 121 18 diagnostics diagnostic NNS cord-318625-hf7fgtnp 121 19 and and CC cord-318625-hf7fgtnp 121 20 vaccines vaccine NNS cord-318625-hf7fgtnp 121 21 against against IN cord-318625-hf7fgtnp 121 22 SARS SARS NNP cord-318625-hf7fgtnp 121 23 - - HYPH cord-318625-hf7fgtnp 121 24 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 121 25 . . . cord-318625-hf7fgtnp 122 1 In in IN cord-318625-hf7fgtnp 122 2 the the DT cord-318625-hf7fgtnp 122 3 present present JJ cord-318625-hf7fgtnp 122 4 study study NN cord-318625-hf7fgtnp 122 5 , , , cord-318625-hf7fgtnp 122 6 peptide peptide NN cord-318625-hf7fgtnp 122 7 segments segment NNS cord-318625-hf7fgtnp 122 8 were be VBD cord-318625-hf7fgtnp 122 9 identified identify VBN cord-318625-hf7fgtnp 122 10 on on IN cord-318625-hf7fgtnp 122 11 S s NN cord-318625-hf7fgtnp 122 12 proteins protein NNS cord-318625-hf7fgtnp 122 13 for for IN cord-318625-hf7fgtnp 122 14 the the DT cord-318625-hf7fgtnp 122 15 development development NN cord-318625-hf7fgtnp 122 16 of of IN cord-318625-hf7fgtnp 122 17 diagnostics diagnostic NNS cord-318625-hf7fgtnp 122 18 and and CC cord-318625-hf7fgtnp 122 19 vaccines vaccine NNS cord-318625-hf7fgtnp 122 20 against against IN cord-318625-hf7fgtnp 122 21 SARS SARS NNP cord-318625-hf7fgtnp 122 22 - - HYPH cord-318625-hf7fgtnp 122 23 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 122 24 . . . cord-318625-hf7fgtnp 123 1 The the DT cord-318625-hf7fgtnp 123 2 recent recent JJ cord-318625-hf7fgtnp 123 3 availability availability NN cord-318625-hf7fgtnp 123 4 of of IN cord-318625-hf7fgtnp 123 5 3D 3D NNP cord-318625-hf7fgtnp 123 6 data datum NNS cord-318625-hf7fgtnp 123 7 on on IN cord-318625-hf7fgtnp 123 8 2019-CoV 2019-cov CD cord-318625-hf7fgtnp 123 9 S S NNP cord-318625-hf7fgtnp 123 10 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 123 11 has have VBZ cord-318625-hf7fgtnp 123 12 helped help VBN cord-318625-hf7fgtnp 123 13 the the DT cord-318625-hf7fgtnp 123 14 search search NN cord-318625-hf7fgtnp 123 15 . . . cord-318625-hf7fgtnp 124 1 SARS SARS NNP cord-318625-hf7fgtnp 124 2 - - HYPH cord-318625-hf7fgtnp 124 3 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 124 4 , , , cord-318625-hf7fgtnp 124 5 being be VBG cord-318625-hf7fgtnp 124 6 an an DT cord-318625-hf7fgtnp 124 7 RNA RNA NNP cord-318625-hf7fgtnp 124 8 virus virus NN cord-318625-hf7fgtnp 124 9 , , , cord-318625-hf7fgtnp 124 10 has have VBZ cord-318625-hf7fgtnp 124 11 a a DT cord-318625-hf7fgtnp 124 12 high high JJ cord-318625-hf7fgtnp 124 13 mutation mutation NN cord-318625-hf7fgtnp 124 14 rate rate NN cord-318625-hf7fgtnp 124 15 and and CC cord-318625-hf7fgtnp 124 16 undergoes undergo VBZ cord-318625-hf7fgtnp 124 17 active active JJ cord-318625-hf7fgtnp 124 18 recombination recombination NN cord-318625-hf7fgtnp 124 19 ( ( -LRB- cord-318625-hf7fgtnp 124 20 Yi Yi NNP cord-318625-hf7fgtnp 124 21 , , , cord-318625-hf7fgtnp 124 22 2020 2020 CD cord-318625-hf7fgtnp 124 23 ) ) -RRB- cord-318625-hf7fgtnp 124 24 . . . cord-318625-hf7fgtnp 125 1 Although although IN cord-318625-hf7fgtnp 125 2 the the DT cord-318625-hf7fgtnp 125 3 peptides peptide NNS cord-318625-hf7fgtnp 125 4 identified identify VBN cord-318625-hf7fgtnp 125 5 are be VBP cord-318625-hf7fgtnp 125 6 ideal ideal JJ cord-318625-hf7fgtnp 125 7 candidates candidate NNS cord-318625-hf7fgtnp 125 8 as as IN cord-318625-hf7fgtnp 125 9 immunogens immunogen NNS cord-318625-hf7fgtnp 125 10 for for IN cord-318625-hf7fgtnp 125 11 the the DT cord-318625-hf7fgtnp 125 12 development development NN cord-318625-hf7fgtnp 125 13 of of IN cord-318625-hf7fgtnp 125 14 peptide peptide NN cord-318625-hf7fgtnp 125 15 - - HYPH cord-318625-hf7fgtnp 125 16 based base VBN cord-318625-hf7fgtnp 125 17 diagnostics diagnostic NNS cord-318625-hf7fgtnp 125 18 and and CC cord-318625-hf7fgtnp 125 19 vaccines vaccine NNS cord-318625-hf7fgtnp 125 20 , , , cord-318625-hf7fgtnp 125 21 more more JJR cord-318625-hf7fgtnp 125 22 refinement refinement NN cord-318625-hf7fgtnp 125 23 and and CC cord-318625-hf7fgtnp 125 24 lab lab NN cord-318625-hf7fgtnp 125 25 trials trial NNS cord-318625-hf7fgtnp 125 26 are be VBP cord-318625-hf7fgtnp 125 27 essential essential JJ cord-318625-hf7fgtnp 125 28 steps step NNS cord-318625-hf7fgtnp 125 29 that that WDT cord-318625-hf7fgtnp 125 30 are be VBP cord-318625-hf7fgtnp 125 31 yet yet RB cord-318625-hf7fgtnp 125 32 to to TO cord-318625-hf7fgtnp 125 33 be be VB cord-318625-hf7fgtnp 125 34 undertaken undertake VBN cord-318625-hf7fgtnp 125 35 for for IN cord-318625-hf7fgtnp 125 36 early early JJ cord-318625-hf7fgtnp 125 37 development development NN cord-318625-hf7fgtnp 125 38 before before IN cord-318625-hf7fgtnp 125 39 the the DT cord-318625-hf7fgtnp 125 40 identified identify VBN cord-318625-hf7fgtnp 125 41 epitopes epitope NNS cord-318625-hf7fgtnp 125 42 are be VBP cord-318625-hf7fgtnp 125 43 rendered render VBN cord-318625-hf7fgtnp 125 44 obsolete obsolete JJ cord-318625-hf7fgtnp 125 45 . . . cord-318625-hf7fgtnp 126 1 numbers number NNS cord-318625-hf7fgtnp 126 2 . . . cord-318625-hf7fgtnp 127 1 High high JJ cord-318625-hf7fgtnp 127 2 ASA ASA NNP cord-318625-hf7fgtnp 127 3 value value NN cord-318625-hf7fgtnp 127 4 means mean VBZ cord-318625-hf7fgtnp 127 5 the the DT cord-318625-hf7fgtnp 127 6 solvent solvent NN cord-318625-hf7fgtnp 127 7 accessibility accessibility NN cord-318625-hf7fgtnp 127 8 score score NN cord-318625-hf7fgtnp 127 9 is be VBZ cord-318625-hf7fgtnp 127 10 relatively relatively RB cord-318625-hf7fgtnp 127 11 higher high JJR cord-318625-hf7fgtnp 127 12 for for IN cord-318625-hf7fgtnp 127 13 that that DT cord-318625-hf7fgtnp 127 14 region region NN cord-318625-hf7fgtnp 127 15 and and CC cord-318625-hf7fgtnp 127 16 it -PRON- PRP cord-318625-hf7fgtnp 127 17 is be VBZ cord-318625-hf7fgtnp 127 18 more more JJR cord-318625-hf7fgtnp 127 19 surface surface NN cord-318625-hf7fgtnp 127 20 exposed expose VBN cord-318625-hf7fgtnp 127 21 with with IN cord-318625-hf7fgtnp 127 22 respect respect NN cord-318625-hf7fgtnp 127 23 to to IN cord-318625-hf7fgtnp 127 24 its -PRON- PRP$ cord-318625-hf7fgtnp 127 25 neighbours neighbour NNS cord-318625-hf7fgtnp 127 26 . . . cord-318625-hf7fgtnp 127 27 _SP cord-318625-hf7fgtnp 128 1 NetMHCcons netmhccon NNS cord-318625-hf7fgtnp 128 2 : : : cord-318625-hf7fgtnp 129 1 a a DT cord-318625-hf7fgtnp 129 2 consensus consensus NN cord-318625-hf7fgtnp 129 3 method method NN cord-318625-hf7fgtnp 129 4 for for IN cord-318625-hf7fgtnp 129 5 the the DT cord-318625-hf7fgtnp 129 6 major major JJ cord-318625-hf7fgtnp 129 7 histocompatibility histocompatibility NN cord-318625-hf7fgtnp 129 8 complex complex JJ cord-318625-hf7fgtnp 129 9 class class NN cord-318625-hf7fgtnp 130 1 I -PRON- PRP cord-318625-hf7fgtnp 130 2 predictions prediction VBZ cord-318625-hf7fgtnp 130 3 Structure Structure NNP cord-318625-hf7fgtnp 130 4 of of IN cord-318625-hf7fgtnp 130 5 the the DT cord-318625-hf7fgtnp 130 6 SARS SARS NNP cord-318625-hf7fgtnp 130 7 - - HYPH cord-318625-hf7fgtnp 130 8 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 130 9 spike spike NN cord-318625-hf7fgtnp 130 10 receptor receptor NN cord-318625-hf7fgtnp 130 11 - - HYPH cord-318625-hf7fgtnp 130 12 binding bind VBG cord-318625-hf7fgtnp 130 13 domain domain NN cord-318625-hf7fgtnp 130 14 bound bind VBN cord-318625-hf7fgtnp 130 15 to to IN cord-318625-hf7fgtnp 130 16 the the DT cord-318625-hf7fgtnp 130 17 ACE2 ACE2 NNP cord-318625-hf7fgtnp 130 18 receptor receptor NN cord-318625-hf7fgtnp 130 19 Functional functional JJ cord-318625-hf7fgtnp 130 20 assessment assessment NN cord-318625-hf7fgtnp 130 21 of of IN cord-318625-hf7fgtnp 130 22 cell cell NN cord-318625-hf7fgtnp 130 23 entry entry NN cord-318625-hf7fgtnp 130 24 and and CC cord-318625-hf7fgtnp 130 25 receptor receptor NN cord-318625-hf7fgtnp 130 26 usage usage NN cord-318625-hf7fgtnp 130 27 for for IN cord-318625-hf7fgtnp 130 28 SARS SARS NNP cord-318625-hf7fgtnp 130 29 - - HYPH cord-318625-hf7fgtnp 130 30 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 130 31 and and CC cord-318625-hf7fgtnp 130 32 other other JJ cord-318625-hf7fgtnp 130 33 lineage lineage NN cord-318625-hf7fgtnp 130 34 B B NNP cord-318625-hf7fgtnp 130 35 betacoronaviruses betacoronaviruses NNP cord-318625-hf7fgtnp 130 36 Structure Structure NNP cord-318625-hf7fgtnp 130 37 , , , cord-318625-hf7fgtnp 130 38 Function Function NNP cord-318625-hf7fgtnp 130 39 , , , cord-318625-hf7fgtnp 130 40 and and CC cord-318625-hf7fgtnp 130 41 Evolution evolution NN cord-318625-hf7fgtnp 130 42 of of IN cord-318625-hf7fgtnp 130 43 Coronavirus Coronavirus NNP cord-318625-hf7fgtnp 130 44 Spike Spike NNP cord-318625-hf7fgtnp 130 45 Proteins Proteins NNP cord-318625-hf7fgtnp 130 46 Peptide Peptide NNP cord-318625-hf7fgtnp 130 47 Vaccine vaccine NN cord-318625-hf7fgtnp 130 48 : : : cord-318625-hf7fgtnp 131 1 Progress Progress NNP cord-318625-hf7fgtnp 131 2 and and CC cord-318625-hf7fgtnp 131 3 Challenges Challenges NNP cord-318625-hf7fgtnp 131 4 Peptide Peptide NNP cord-318625-hf7fgtnp 131 5 Based base VBN cord-318625-hf7fgtnp 131 6 Viral Viral NNP cord-318625-hf7fgtnp 131 7 Detection Detection NNP cord-318625-hf7fgtnp 131 8 Systems Systems NNPS cord-318625-hf7fgtnp 131 9 for for IN cord-318625-hf7fgtnp 131 10 Effective effective JJ cord-318625-hf7fgtnp 131 11 Diagnosis Diagnosis NNP cord-318625-hf7fgtnp 131 12 of of IN cord-318625-hf7fgtnp 131 13 Common common JJ cord-318625-hf7fgtnp 131 14 Viral Viral NNP cord-318625-hf7fgtnp 131 15 Infections Infections NNPS cord-318625-hf7fgtnp 131 16 in in IN cord-318625-hf7fgtnp 131 17 India India NNP cord-318625-hf7fgtnp 131 18 Peptide Peptide NNP cord-318625-hf7fgtnp 131 19 based base VBN cord-318625-hf7fgtnp 131 20 diagnostics diagnostic NNS cord-318625-hf7fgtnp 131 21 : : : cord-318625-hf7fgtnp 131 22 are be VBP cord-318625-hf7fgtnp 131 23 random random JJ cord-318625-hf7fgtnp 131 24 -se -se NNP cord-318625-hf7fgtnp 131 25 quence quence NN cord-318625-hf7fgtnp 131 26 peptides peptide NNS cord-318625-hf7fgtnp 131 27 more more RBR cord-318625-hf7fgtnp 131 28 useful useful JJ cord-318625-hf7fgtnp 131 29 than than IN cord-318625-hf7fgtnp 131 30 tiling tile VBG cord-318625-hf7fgtnp 131 31 proteome proteome NN cord-318625-hf7fgtnp 131 32 sequences sequence NNS cord-318625-hf7fgtnp 131 33 ? ? . cord-318625-hf7fgtnp 132 1 Prediction prediction NN cord-318625-hf7fgtnp 132 2 of of IN cord-318625-hf7fgtnp 132 3 MHC MHC NNP cord-318625-hf7fgtnp 132 4 class class NN cord-318625-hf7fgtnp 132 5 II II NNP cord-318625-hf7fgtnp 132 6 binding bind VBG cord-318625-hf7fgtnp 132 7 affinity affinity NN cord-318625-hf7fgtnp 132 8 using use VBG cord-318625-hf7fgtnp 132 9 SMMalign SMMalign NNP cord-318625-hf7fgtnp 132 10 , , , cord-318625-hf7fgtnp 132 11 a a DT cord-318625-hf7fgtnp 132 12 novel novel JJ cord-318625-hf7fgtnp 132 13 stabilization stabilization NN cord-318625-hf7fgtnp 132 14 matrix matrix NN cord-318625-hf7fgtnp 132 15 alignment alignment NN cord-318625-hf7fgtnp 132 16 method method NN cord-318625-hf7fgtnp 132 17 Reliable reliable JJ cord-318625-hf7fgtnp 132 18 prediction prediction NN cord-318625-hf7fgtnp 132 19 of of IN cord-318625-hf7fgtnp 132 20 T t NN cord-318625-hf7fgtnp 132 21 - - HYPH cord-318625-hf7fgtnp 132 22 cell cell NN cord-318625-hf7fgtnp 132 23 epitopes epitope NNS cord-318625-hf7fgtnp 132 24 using use VBG cord-318625-hf7fgtnp 132 25 neural neural JJ cord-318625-hf7fgtnp 132 26 networks network NNS cord-318625-hf7fgtnp 132 27 with with IN cord-318625-hf7fgtnp 132 28 novel novel JJ cord-318625-hf7fgtnp 132 29 sequence sequence NN cord-318625-hf7fgtnp 132 30 representations representation NNS cord-318625-hf7fgtnp 132 31 Design Design NNP cord-318625-hf7fgtnp 132 32 of of IN cord-318625-hf7fgtnp 132 33 an an DT cord-318625-hf7fgtnp 132 34 epitope epitope NN cord-318625-hf7fgtnp 132 35 -based -based JJ cord-318625-hf7fgtnp 132 36 peptide peptide NN cord-318625-hf7fgtnp 132 37 vaccine vaccine NN cord-318625-hf7fgtnp 132 38 agai agai NNP cord-318625-hf7fgtnp 132 39 nst nst NNP cord-318625-hf7fgtnp 132 40 spi spi NNP cord-318625-hf7fgtnp 132 41 ke ke NNP cord-318625-hf7fgtnp 132 42 protein protein NNP cord-318625-hf7fgtnp 132 43 of of IN cord-318625-hf7fgtnp 132 44 human human JJ cord-318625-hf7fgtnp 132 45 coronavirus coronavirus NN cord-318625-hf7fgtnp 132 46 : : : cord-318625-hf7fgtnp 132 47 an an DT cord-318625-hf7fgtnp 132 48 in in IN cord-318625-hf7fgtnp 132 49 silico silico NN cord-318625-hf7fgtnp 132 50 approach approach NN cord-318625-hf7fgtnp 132 51 Proteolytic proteolytic JJ cord-318625-hf7fgtnp 132 52 processing processing NN cord-318625-hf7fgtnp 132 53 of of IN cord-318625-hf7fgtnp 132 54 Middle Middle NNP cord-318625-hf7fgtnp 132 55 East East NNP cord-318625-hf7fgtnp 132 56 respiratory respiratory JJ cord-318625-hf7fgtnp 132 57 syndrome syndrome NN cord-318625-hf7fgtnp 132 58 coronavirus coronavirus NN cord-318625-hf7fgtnp 132 59 spikes spike NNS cord-318625-hf7fgtnp 132 60 expands expand VBZ cord-318625-hf7fgtnp 132 61 virus virus NN cord-318625-hf7fgtnp 132 62 tropism tropism NN cord-318625-hf7fgtnp 132 63 Generating generate VBG cord-318625-hf7fgtnp 132 64 quantitative quantitative JJ cord-318625-hf7fgtnp 132 65 models model NNS cord-318625-hf7fgtnp 132 66 describing describe VBG cord-318625-hf7fgtnp 132 67 the the DT cord-318625-hf7fgtnp 132 68 sequence sequence NN cord-318625-hf7fgtnp 132 69 specificity specificity NN cord-318625-hf7fgtnp 132 70 of of IN cord-318625-hf7fgtnp 132 71 biological biological JJ cord-318625-hf7fgtnp 132 72 processes process NNS cord-318625-hf7fgtnp 132 73 with with IN cord-318625-hf7fgtnp 132 74 the the DT cord-318625-hf7fgtnp 132 75 stabilized stabilize VBN cord-318625-hf7fgtnp 132 76 matrix matrix NN cord-318625-hf7fgtnp 132 77 method method NN cord-318625-hf7fgtnp 132 78 Antibody antibody NN cord-318625-hf7fgtnp 132 79 - - HYPH cord-318625-hf7fgtnp 132 80 protein protein NN cord-318625-hf7fgtnp 132 81 interactions interaction NNS cord-318625-hf7fgtnp 132 82 : : : cord-318625-hf7fgtnp 132 83 benchmark benchmark NN cord-318625-hf7fgtnp 132 84 datasets dataset NNS cord-318625-hf7fgtnp 132 85 and and CC cord-318625-hf7fgtnp 132 86 prediction prediction NN cord-318625-hf7fgtnp 132 87 tools tool NNS cord-318625-hf7fgtnp 132 88 evaluation evaluation NN cord-318625-hf7fgtnp 132 89 More More JJR cord-318625-hf7fgtnp 132 90 than than IN cord-318625-hf7fgtnp 132 91 one one CD cord-318625-hf7fgtnp 132 92 reason reason NN cord-318625-hf7fgtnp 132 93 to to TO cord-318625-hf7fgtnp 132 94 rethink rethink VB cord-318625-hf7fgtnp 132 95 the the DT cord-318625-hf7fgtnp 132 96 use use NN cord-318625-hf7fgtnp 132 97 of of IN cord-318625-hf7fgtnp 132 98 peptide peptide NN cord-318625-hf7fgtnp 132 99 s s NN cord-318625-hf7fgtnp 132 100 in in IN cord-318625-hf7fgtnp 132 101 vaccine vaccine NN cord-318625-hf7fgtnp 132 102 design design NN cord-318625-hf7fgtnp 132 103 T T NNP cord-318625-hf7fgtnp 132 104 cell cell NN cord-318625-hf7fgtnp 133 1 re re IN cord-318625-hf7fgtnp 133 2 sponse sponse NNP cord-318625-hf7fgtnp 133 3 s s NNP cord-318625-hf7fgtnp 133 4 to to IN cord-318625-hf7fgtnp 133 5 viral viral JJ cord-318625-hf7fgtnp 133 6 infections infection NNS cord-318625-hf7fgtnp 133 7 -opportunities -opportunities : cord-318625-hf7fgtnp 133 8 for for IN cord-318625-hf7fgtnp 133 9 Peptide Peptide NNP cord-318625-hf7fgtnp 133 10 vaccination vaccination NN cord-318625-hf7fgtnp 133 11 Prediction prediction NN cord-318625-hf7fgtnp 133 12 of of IN cord-318625-hf7fgtnp 133 13 continuous continuous JJ cord-318625-hf7fgtnp 133 14 B b NN cord-318625-hf7fgtnp 133 15 - - HYPH cord-318625-hf7fgtnp 133 16 cell cell NN cord-318625-hf7fgtnp 133 17 epitopes epitope NNS cord-318625-hf7fgtnp 133 18 in in IN cord-318625-hf7fgtnp 133 19 an an DT cord-318625-hf7fgtnp 133 20 antigen antigen NN cord-318625-hf7fgtnp 133 21 using use VBG cord-318625-hf7fgtnp 133 22 re re IN cord-318625-hf7fgtnp 133 23 curre curre NNP cord-318625-hf7fgtnp 133 24 nt nt RB cord-318625-hf7fgtnp 133 25 neural neural JJ cord-318625-hf7fgtnp 133 26 network network NN cord-318625-hf7fgtnp 133 27 Generation generation NN cord-318625-hf7fgtnp 133 28 of of IN cord-318625-hf7fgtnp 133 29 tissue tissue NN cord-318625-hf7fgtnp 133 30 -specific -specific JJ cord-318625-hf7fgtnp 133 31 and and CC cord-318625-hf7fgtnp 133 32 promiscuous promiscuous JJ cord-318625-hf7fgtnp 133 33 HLA HLA NNP cord-318625-hf7fgtnp 133 34 ligand ligand NN cord-318625-hf7fgtnp 133 35 databases database NNS cord-318625-hf7fgtnp 133 36 using use VBG cord-318625-hf7fgtnp 133 37 DNA dna NN cord-318625-hf7fgtnp 133 38 microarrays microarray NNS cord-318625-hf7fgtnp 133 39 and and CC cord-318625-hf7fgtnp 133 40 virtual virtual JJ cord-318625-hf7fgtnp 133 41 HLA HLA NNP cord-318625-hf7fgtnp 133 42 class class NN cord-318625-hf7fgtnp 133 43 II II NNP cord-318625-hf7fgtnp 133 44 matrices matrix NNS cord-318625-hf7fgtnp 133 45 Characterization characterization NN cord-318625-hf7fgtnp 133 46 of of IN cord-318625-hf7fgtnp 133 47 the the DT cord-318625-hf7fgtnp 133 48 receptor receptor NN cord-318625-hf7fgtnp 133 49 - - HYPH cord-318625-hf7fgtnp 133 50 binding bind VBG cord-318625-hf7fgtnp 133 51 domain domain NN cord-318625-hf7fgtnp 133 52 ( ( -LRB- cord-318625-hf7fgtnp 133 53 RBD RBD NNP cord-318625-hf7fgtnp 133 54 ) ) -RRB- cord-318625-hf7fgtnp 133 55 of of IN cord-318625-hf7fgtnp 133 56 2019 2019 CD cord-318625-hf7fgtnp 133 57 novel novel JJ cord-318625-hf7fgtnp 133 58 coronavirus coronavirus NN cord-318625-hf7fgtnp 133 59 : : : cord-318625-hf7fgtnp 133 60 implication implication NN cord-318625-hf7fgtnp 133 61 for for IN cord-318625-hf7fgtnp 133 62 development development NN cord-318625-hf7fgtnp 133 63 of of IN cord-318625-hf7fgtnp 133 64 RBD RBD NNP cord-318625-hf7fgtnp 133 65 protein protein NN cord-318625-hf7fgtnp 133 66 as as IN cord-318625-hf7fgtnp 133 67 a a DT cord-318625-hf7fgtnp 133 68 viral viral JJ cord-318625-hf7fgtnp 133 69 attachment attachment NN cord-318625-hf7fgtnp 133 70 inhibitor inhibitor NN cord-318625-hf7fgtnp 133 71 and and CC cord-318625-hf7fgtnp 133 72 vaccine vaccine NN cord-318625-hf7fgtnp 133 73 Structural structural JJ cord-318625-hf7fgtnp 133 74 basis basis NN cord-318625-hf7fgtnp 133 75 for for IN cord-318625-hf7fgtnp 133 76 human human JJ cord-318625-hf7fgtnp 133 77 coronavirus coronavirus NN cord-318625-hf7fgtnp 133 78 attachment attachment NN cord-318625-hf7fgtnp 133 79 to to IN cord-318625-hf7fgtnp 133 80 sialic sialic JJ cord-318625-hf7fgtnp 133 81 acid acid NN cord-318625-hf7fgtnp 133 82 receptors receptor NNS cord-318625-hf7fgtnp 134 1 The the DT cord-318625-hf7fgtnp 134 2 Immune Immune NNP cord-318625-hf7fgtnp 134 3 Epitope Epitope NNP cord-318625-hf7fgtnp 134 4 Database database NN cord-318625-hf7fgtnp 134 5 ( ( -LRB- cord-318625-hf7fgtnp 134 6 IEDB IEDB NNP cord-318625-hf7fgtnp 134 7 ) ) -RRB- cord-318625-hf7fgtnp 134 8 : : : cord-318625-hf7fgtnp 135 1 2018 2018 CD cord-318625-hf7fgtnp 135 2 update update NN cord-318625-hf7fgtnp 135 3 Structure Structure NNP cord-318625-hf7fgtnp 135 4 , , , cord-318625-hf7fgtnp 135 5 Functi Functi NNP cord-318625-hf7fgtnp 135 6 on on RP cord-318625-hf7fgtnp 135 7 , , , cord-318625-hf7fgtnp 135 8 and and CC cord-318625-hf7fgtnp 135 9 Antigenicity Antigenicity NNP cord-318625-hf7fgtnp 135 10 of of IN cord-318625-hf7fgtnp 135 11 the the DT cord-318625-hf7fgtnp 135 12 SARS SARS NNP cord-318625-hf7fgtnp 135 13 - - HYPH cord-318625-hf7fgtnp 135 14 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 135 15 Spike Spike NNP cord-318625-hf7fgtnp 135 16 Glycoprotein Glycoprotein NNP cord-318625-hf7fgtnp 135 17 . . . cord-318625-hf7fgtnp 136 1 Cell cell NN cord-318625-hf7fgtnp 136 2 Tectonic tectonic JJ cord-318625-hf7fgtnp 136 3 conformational conformational JJ cord-318625-hf7fgtnp 136 4 changes change NNS cord-318625-hf7fgtnp 136 5 of of IN cord-318625-hf7fgtnp 136 6 a a DT cord-318625-hf7fgtnp 136 7 coronavirus coronavirus NN cord-318625-hf7fgtnp 136 8 spike spike NN cord-318625-hf7fgtnp 136 9 glycoprotein glycoprotein NN cord-318625-hf7fgtnp 136 10 promote promote VBP cord-318625-hf7fgtnp 136 11 membrane membrane NN cord-318625-hf7fgtnp 136 12 fusion fusion NN cord-318625-hf7fgtnp 136 13 Unexpected unexpected JJ cord-318625-hf7fgtnp 136 14 Receptor Receptor NNP cord-318625-hf7fgtnp 136 15 Functional functional JJ cord-318625-hf7fgtnp 136 16 Mimicry Mimicry NNP cord-318625-hf7fgtnp 137 1 Elucidates elucidate VBZ cord-318625-hf7fgtnp 137 2 Activation Activation NNP cord-318625-hf7fgtnp 137 3 of of IN cord-318625-hf7fgtnp 137 4 Coronavirus Coronavirus NNP cord-318625-hf7fgtnp 137 5 Fusion Fusion NNP cord-318625-hf7fgtnp 137 6 Structural Structural NNP cord-318625-hf7fgtnp 137 7 and and CC cord-318625-hf7fgtnp 137 8 Functional Functional NNP cord-318625-hf7fgtnp 137 9 Basis Basis NNP cord-318625-hf7fgtnp 137 10 of of IN cord-318625-hf7fgtnp 137 11 SARS SARS NNP cord-318625-hf7fgtnp 137 12 - - HYPH cord-318625-hf7fgtnp 137 13 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 137 14 Entry Entry NNP cord-318625-hf7fgtnp 137 15 by by IN cord-318625-hf7fgtnp 137 16 Using use VBG cord-318625-hf7fgtnp 137 17 Human Human NNP cord-318625-hf7fgtnp 137 18 ACE2 ACE2 NNP cord-318625-hf7fgtnp 137 19 WHO WHO NNP cord-318625-hf7fgtnp 137 20 Director Director NNP cord-318625-hf7fgtnp 137 21 - - HYPH cord-318625-hf7fgtnp 137 22 General General NNP cord-318625-hf7fgtnp 137 23 's 's POS cord-318625-hf7fgtnp 137 24 opening opening NN cord-318625-hf7fgtnp 137 25 remarks remark NNS cord-318625-hf7fgtnp 137 26 at at IN cord-318625-hf7fgtnp 137 27 the the DT cord-318625-hf7fgtnp 137 28 media medium NNS cord-318625-hf7fgtnp 137 29 briefing briefing NN cord-318625-hf7fgtnp 137 30 on on IN cord-318625-hf7fgtnp 137 31 COVID-19 COVID-19 NNP cord-318625-hf7fgtnp 137 32 -11 -11 NNP cord-318625-hf7fgtnp 137 33 Cryo Cryo NNP cord-318625-hf7fgtnp 137 34 - - HYPH cord-318625-hf7fgtnp 137 35 EM EM NNP cord-318625-hf7fgtnp 137 36 structure structure NN cord-318625-hf7fgtnp 137 37 of of IN cord-318625-hf7fgtnp 137 38 the the DT cord-318625-hf7fgtnp 137 39 2019-nCoV 2019-ncov CD cord-318625-hf7fgtnp 137 40 spike spike NN cord-318625-hf7fgtnp 137 41 in in IN cord-318625-hf7fgtnp 137 42 the the DT cord-318625-hf7fgtnp 137 43 prefusion prefusion NN cord-318625-hf7fgtnp 137 44 conformation conformation NN cord-318625-hf7fgtnp 138 1 A a DT cord-318625-hf7fgtnp 138 2 new new JJ cord-318625-hf7fgtnp 138 3 coronavirus coronavirus NN cord-318625-hf7fgtnp 138 4 associated associate VBN cord-318625-hf7fgtnp 138 5 with with IN cord-318625-hf7fgtnp 138 6 human human JJ cord-318625-hf7fgtnp 138 7 respiratory respiratory JJ cord-318625-hf7fgtnp 138 8 disease disease NN cord-318625-hf7fgtnp 138 9 in in IN cord-318625-hf7fgtnp 138 10 China China NNP cord-318625-hf7fgtnp 138 11 Characteristics Characteristics NNPS cord-318625-hf7fgtnp 138 12 of of IN cord-318625-hf7fgtnp 138 13 and and CC cord-318625-hf7fgtnp 138 14 Important important JJ cord-318625-hf7fgtnp 138 15 Lessons lesson NNS cord-318625-hf7fgtnp 138 16 From from IN cord-318625-hf7fgtnp 138 17 the the DT cord-318625-hf7fgtnp 138 18 Coronavirus Coronavirus NNP cord-318625-hf7fgtnp 138 19 Disease Disease NNP cord-318625-hf7fgtnp 138 20 2019 2019 CD cord-318625-hf7fgtnp 139 1 ( ( -LRB- cord-318625-hf7fgtnp 139 2 COVID-19 COVID-19 NNP cord-318625-hf7fgtnp 139 3 ) ) -RRB- cord-318625-hf7fgtnp 139 4 Outbreak outbreak NN cord-318625-hf7fgtnp 139 5 in in IN cord-318625-hf7fgtnp 139 6 China China NNP cord-318625-hf7fgtnp 139 7 Glycan Glycan NNP cord-318625-hf7fgtnp 139 8 Shield Shield NNP cord-318625-hf7fgtnp 139 9 and and CC cord-318625-hf7fgtnp 139 10 Fusion Fusion NNP cord-318625-hf7fgtnp 139 11 Activation Activation NNP cord-318625-hf7fgtnp 139 12 of of IN cord-318625-hf7fgtnp 139 13 a a DT cord-318625-hf7fgtnp 139 14 Deltacoronavirus Deltacoronavirus NNP cord-318625-hf7fgtnp 139 15 Spike Spike NNP cord-318625-hf7fgtnp 139 16 Glycoprotein Glycoprotein NNP cord-318625-hf7fgtnp 139 17 Fine fine RB cord-318625-hf7fgtnp 139 18 - - HYPH cord-318625-hf7fgtnp 139 19 Tuned tune VBN cord-318625-hf7fgtnp 139 20 for for IN cord-318625-hf7fgtnp 139 21 Enteric enteric JJ cord-318625-hf7fgtnp 139 22 Infections Infections NNPS cord-318625-hf7fgtnp 139 23 2019 2019 CD cord-318625-hf7fgtnp 140 1 novel novel JJ cord-318625-hf7fgtnp 140 2 coronavirus coronavirus NN cord-318625-hf7fgtnp 140 3 is be VBZ cord-318625-hf7fgtnp 140 4 undergoing undergo VBG cord-318625-hf7fgtnp 140 5 active active JJ cord-318625-hf7fgtnp 140 6 recombination recombination NN cord-318625-hf7fgtnp 140 7 Screening screening NN cord-318625-hf7fgtnp 140 8 of of IN cord-318625-hf7fgtnp 140 9 specific specific JJ cord-318625-hf7fgtnp 140 10 diagnostic diagnostic JJ cord-318625-hf7fgtnp 140 11 peptides peptide NNS cord-318625-hf7fgtnp 140 12 of of IN cord-318625-hf7fgtnp 140 13 swine swine NN cord-318625-hf7fgtnp 140 14 hepatitis hepatitis NN cord-318625-hf7fgtnp 140 15 E e NN cord-318625-hf7fgtnp 140 16 virus virus NN cord-318625-hf7fgtnp 141 1 A a DT cord-318625-hf7fgtnp 141 2 Novel Novel NNP cord-318625-hf7fgtnp 141 3 Coronavirus Coronavirus NNP cord-318625-hf7fgtnp 141 4 from from IN cord-318625-hf7fgtnp 141 5 Patients patient NNS cord-318625-hf7fgtnp 141 6 with with IN cord-318625-hf7fgtnp 141 7 Pneumonia Pneumonia NNP cord-318625-hf7fgtnp 141 8 in in IN cord-318625-hf7fgtnp 141 9 China China NNP cord-318625-hf7fgtnp 141 10 _SP cord-318625-hf7fgtnp 141 11 Figure Figure NNP cord-318625-hf7fgtnp 141 12 3 3 CD cord-318625-hf7fgtnp 141 13 . . . cord-318625-hf7fgtnp 142 1 Our -PRON- PRP$ cord-318625-hf7fgtnp 142 2 selected select VBN cord-318625-hf7fgtnp 142 3 peptides peptide NNS cord-318625-hf7fgtnp 142 4 are be VBP cord-318625-hf7fgtnp 142 5 highlighted highlight VBN cord-318625-hf7fgtnp 142 6 on on IN cord-318625-hf7fgtnp 142 7 spike spike NN cord-318625-hf7fgtnp 142 8 protein protein NN cord-318625-hf7fgtnp 142 9 of of IN cord-318625-hf7fgtnp 142 10 SARS SARS NNP cord-318625-hf7fgtnp 142 11 - - HYPH cord-318625-hf7fgtnp 142 12 CoV-2 CoV-2 NNP cord-318625-hf7fgtnp 142 13 protein protein NN cord-318625-hf7fgtnp 142 14 structure structure NN cord-318625-hf7fgtnp 142 15 downloaded download VBN cord-318625-hf7fgtnp 142 16 from from IN cord-318625-hf7fgtnp 142 17 PDB PDB NNP cord-318625-hf7fgtnp 142 18 ( ( -LRB- cord-318625-hf7fgtnp 142 19 ID ID NNP cord-318625-hf7fgtnp 142 20 : : : cord-318625-hf7fgtnp 142 21 6VSB 6VSB NNP cord-318625-hf7fgtnp 142 22 ) ) -RRB- cord-318625-hf7fgtnp 142 23 . . . cord-318625-hf7fgtnp 143 1 5 5 CD cord-318625-hf7fgtnp 143 2 _SP cord-318625-hf7fgtnp 144 1 249 249 CD cord-318625-hf7fgtnp 144 2 _SP cord-318625-hf7fgtnp 145 1 261 261 CD cord-318625-hf7fgtnp 145 2 _SP cord-318625-hf7fgtnp 145 3 13 13 CD cord-318625-hf7fgtnp 145 4 _SP cord-318625-hf7fgtnp 146 1 LTPGDSSSGWTAG LTPGDSSSGWTAG NNP cord-318625-hf7fgtnp 146 2 _SP cord-318625-hf7fgtnp 147 1 6 6 CD cord-318625-hf7fgtnp 147 2 _SP cord-318625-hf7fgtnp 147 3 278 278 CD cord-318625-hf7fgtnp 147 4 _SP cord-318625-hf7fgtnp 147 5 287 287 CD cord-318625-hf7fgtnp 147 6 _SP cord-318625-hf7fgtnp 147 7 10 10 CD cord-318625-hf7fgtnp 147 8 _SP cord-318625-hf7fgtnp 148 1 KYNENGTITD KYNENGTITD NNP cord-318625-hf7fgtnp 148 2 _SP cord-318625-hf7fgtnp 149 1 7 7 CD cord-318625-hf7fgtnp 149 2 _SP cord-318625-hf7fgtnp 149 3 314 314 CD cord-318625-hf7fgtnp 149 4 _SP cord-318625-hf7fgtnp 149 5 325 325 CD cord-318625-hf7fgtnp 149 6 _SP cord-318625-hf7fgtnp 149 7 12 12 CD cord-318625-hf7fgtnp 149 8 _SP cord-318625-hf7fgtnp 149 9 QTSNFRVQPTES QTSNFRVQPTES NNP cord-318625-hf7fgtnp 149 10 _SP cord-318625-hf7fgtnp 149 11 8 8 CD cord-318625-hf7fgtnp 149 12 _SP cord-318625-hf7fgtnp 150 1 407 407 CD cord-318625-hf7fgtnp 150 2 _SP cord-318625-hf7fgtnp 150 3 428 428 CD cord-318625-hf7fgtnp 150 4 _SP cord-318625-hf7fgtnp 151 1 22 22 CD cord-318625-hf7fgtnp 151 2 _SP cord-318625-hf7fgtnp 152 1 VRQIAPGQTGKIADYNYKLPDD VRQIAPGQTGKIADYNYKLPDD NNP cord-318625-hf7fgtnp 152 2 _SP cord-318625-hf7fgtnp 153 1 9 9 CD cord-318625-hf7fgtnp 153 2 _SP cord-318625-hf7fgtnp 153 3 437 437 CD cord-318625-hf7fgtnp 153 4 _SP cord-318625-hf7fgtnp 154 1 450 450 CD cord-318625-hf7fgtnp 154 2 _SP cord-318625-hf7fgtnp 155 1 14 14 CD cord-318625-hf7fgtnp 155 2 _SP cord-318625-hf7fgtnp 156 1 NSNNLDSKVGGNYN NSNNLDSKVGGNYN NNP cord-318625-hf7fgtnp 156 2 _SP cord-318625-hf7fgtnp 157 1 10 10 CD cord-318625-hf7fgtnp 157 2 _SP cord-318625-hf7fgtnp 158 1 461 461 CD cord-318625-hf7fgtnp 158 2 _SP cord-318625-hf7fgtnp 159 1 485 485 CD cord-318625-hf7fgtnp 159 2 _SP cord-318625-hf7fgtnp 159 3 25 25 CD cord-318625-hf7fgtnp 159 4 _SP cord-318625-hf7fgtnp 159 5 LKPFERDISTEIYQAGSTPCNGVEG LKPFERDISTEIYQAGSTPCNGVEG NNP cord-318625-hf7fgtnp 159 6 _SP cord-318625-hf7fgtnp 160 1 11 11 CD cord-318625-hf7fgtnp 160 2 _SP cord-318625-hf7fgtnp 161 1 493 493 CD cord-318625-hf7fgtnp 161 2 _SP cord-318625-hf7fgtnp 162 1 506 506 CD cord-318625-hf7fgtnp 162 2 _SP cord-318625-hf7fgtnp 163 1 14 14 CD cord-318625-hf7fgtnp 163 2 _SP cord-318625-hf7fgtnp 164 1 QSYGFQPTNGVGYQ QSYGFQPTNGVGYQ NNP cord-318625-hf7fgtnp 164 2 _SP cord-318625-hf7fgtnp 165 1 12 12 CD cord-318625-hf7fgtnp 165 2 _SP cord-318625-hf7fgtnp 166 1 521 521 CD cord-318625-hf7fgtnp 166 2 _SP cord-318625-hf7fgtnp 166 3 533 533 CD cord-318625-hf7fgtnp 166 4 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