id sid tid token lemma pos cord-269353-wgeuh1i2 1 1 key key NN cord-269353-wgeuh1i2 1 2 : : : cord-269353-wgeuh1i2 1 3 cord-269353-wgeuh1i2 cord-269353-wgeuh1i2 NN cord-269353-wgeuh1i2 1 4 authors author NNS cord-269353-wgeuh1i2 1 5 : : : cord-269353-wgeuh1i2 1 6 Tian Tian NNP cord-269353-wgeuh1i2 1 7 , , , cord-269353-wgeuh1i2 1 8 Lin Lin NNP cord-269353-wgeuh1i2 1 9 ; ; : cord-269353-wgeuh1i2 1 10 Shen Shen NNP cord-269353-wgeuh1i2 1 11 , , , cord-269353-wgeuh1i2 1 12 Xuejuan Xuejuan NNP cord-269353-wgeuh1i2 1 13 ; ; : cord-269353-wgeuh1i2 1 14 Murphy Murphy NNP cord-269353-wgeuh1i2 1 15 , , , cord-269353-wgeuh1i2 1 16 Robert Robert NNP cord-269353-wgeuh1i2 1 17 W. W. NNP cord-269353-wgeuh1i2 1 18 ; ; : cord-269353-wgeuh1i2 1 19 Shen Shen NNP cord-269353-wgeuh1i2 1 20 , , , cord-269353-wgeuh1i2 2 1 Yongyi Yongyi NNP cord-269353-wgeuh1i2 2 2 title title NN cord-269353-wgeuh1i2 2 3 : : : cord-269353-wgeuh1i2 3 1 The the DT cord-269353-wgeuh1i2 3 2 adaptation adaptation NN cord-269353-wgeuh1i2 3 3 of of IN cord-269353-wgeuh1i2 3 4 codon codon NN cord-269353-wgeuh1i2 3 5 usage usage NN cord-269353-wgeuh1i2 3 6 of of IN cord-269353-wgeuh1i2 3 7 + + SYM cord-269353-wgeuh1i2 3 8 ssRNA ssrna NN cord-269353-wgeuh1i2 3 9 viruses virus NNS cord-269353-wgeuh1i2 3 10 to to IN cord-269353-wgeuh1i2 3 11 their -PRON- PRP$ cord-269353-wgeuh1i2 3 12 hosts host NNS cord-269353-wgeuh1i2 3 13 date date NN cord-269353-wgeuh1i2 3 14 : : : cord-269353-wgeuh1i2 3 15 2018 2018 CD cord-269353-wgeuh1i2 3 16 - - HYPH cord-269353-wgeuh1i2 3 17 06 06 CD cord-269353-wgeuh1i2 3 18 - - SYM cord-269353-wgeuh1i2 3 19 02 02 CD cord-269353-wgeuh1i2 3 20 journal journal NN cord-269353-wgeuh1i2 3 21 : : : cord-269353-wgeuh1i2 4 1 Infect infect VB cord-269353-wgeuh1i2 4 2 Genet Genet NNP cord-269353-wgeuh1i2 4 3 Evol Evol NNP cord-269353-wgeuh1i2 4 4 DOI doi NN cord-269353-wgeuh1i2 4 5 : : : cord-269353-wgeuh1i2 5 1 10.1016 10.1016 CD cord-269353-wgeuh1i2 5 2 / / NFP cord-269353-wgeuh1i2 5 3 j.meegid.2018.05.034 j.meegid.2018.05.034 . cord-269353-wgeuh1i2 6 1 sha sha NNP cord-269353-wgeuh1i2 6 2 : : : cord-269353-wgeuh1i2 7 1 0f11f8b25665d5282ca3be429069f5d434409178 0f11f8b25665d5282ca3be429069f5d434409178 CD cord-269353-wgeuh1i2 7 2 doc_id doc_id CD cord-269353-wgeuh1i2 7 3 : : : cord-269353-wgeuh1i2 8 1 269353 269353 CD cord-269353-wgeuh1i2 8 2 cord_uid cord_uid NNS cord-269353-wgeuh1i2 8 3 : : : cord-269353-wgeuh1i2 9 1 wgeuh1i2 wgeuh1i2 NNP cord-269353-wgeuh1i2 9 2 Viruses virus NNS cord-269353-wgeuh1i2 9 3 depend depend VBP cord-269353-wgeuh1i2 9 4 on on IN cord-269353-wgeuh1i2 9 5 their -PRON- PRP$ cord-269353-wgeuh1i2 9 6 host host NN cord-269353-wgeuh1i2 9 7 's 's POS cord-269353-wgeuh1i2 9 8 cellular cellular JJ cord-269353-wgeuh1i2 9 9 structure structure NN cord-269353-wgeuh1i2 9 10 to to TO cord-269353-wgeuh1i2 9 11 survive survive VB cord-269353-wgeuh1i2 9 12 . . . cord-269353-wgeuh1i2 10 1 Most Most JJS cord-269353-wgeuh1i2 10 2 of of IN cord-269353-wgeuh1i2 10 3 them -PRON- PRP cord-269353-wgeuh1i2 10 4 do do VBP cord-269353-wgeuh1i2 10 5 not not RB cord-269353-wgeuh1i2 10 6 have have VB cord-269353-wgeuh1i2 10 7 tRNAs trnas CD cord-269353-wgeuh1i2 11 1 , , , cord-269353-wgeuh1i2 11 2 their -PRON- PRP$ cord-269353-wgeuh1i2 11 3 translation translation NN cord-269353-wgeuh1i2 11 4 relies rely VBZ cord-269353-wgeuh1i2 11 5 on on IN cord-269353-wgeuh1i2 11 6 hosts host NNS cord-269353-wgeuh1i2 11 7 ' ' POS cord-269353-wgeuh1i2 11 8 tRNA trna NN cord-269353-wgeuh1i2 11 9 pools pool NNS cord-269353-wgeuh1i2 11 10 . . . cord-269353-wgeuh1i2 12 1 Over over IN cord-269353-wgeuh1i2 12 2 the the DT cord-269353-wgeuh1i2 12 3 course course NN cord-269353-wgeuh1i2 12 4 of of IN cord-269353-wgeuh1i2 12 5 evolution evolution NN cord-269353-wgeuh1i2 12 6 , , , cord-269353-wgeuh1i2 12 7 viruses virus NNS cord-269353-wgeuh1i2 12 8 needed need VBN cord-269353-wgeuh1i2 12 9 to to TO cord-269353-wgeuh1i2 12 10 optimally optimally RB cord-269353-wgeuh1i2 12 11 exploit exploit VB cord-269353-wgeuh1i2 12 12 cellular cellular JJ cord-269353-wgeuh1i2 12 13 processes process NNS cord-269353-wgeuh1i2 12 14 of of IN cord-269353-wgeuh1i2 12 15 their -PRON- PRP$ cord-269353-wgeuh1i2 12 16 host host NN cord-269353-wgeuh1i2 12 17 . . . cord-269353-wgeuh1i2 13 1 Thus thus RB cord-269353-wgeuh1i2 13 2 , , , cord-269353-wgeuh1i2 13 3 codon codon NN cord-269353-wgeuh1i2 13 4 usage usage NN cord-269353-wgeuh1i2 13 5 of of IN cord-269353-wgeuh1i2 13 6 a a DT cord-269353-wgeuh1i2 13 7 virus virus NN cord-269353-wgeuh1i2 13 8 should should MD cord-269353-wgeuh1i2 13 9 coevolve coevolve VB cord-269353-wgeuh1i2 13 10 with with IN cord-269353-wgeuh1i2 13 11 its -PRON- PRP$ cord-269353-wgeuh1i2 13 12 host host NN cord-269353-wgeuh1i2 13 13 to to IN cord-269353-wgeuh1i2 13 14 efficiently efficiently RB cord-269353-wgeuh1i2 13 15 and and CC cord-269353-wgeuh1i2 13 16 rapidly rapidly RB cord-269353-wgeuh1i2 13 17 replicate replicate VB cord-269353-wgeuh1i2 13 18 . . . cord-269353-wgeuh1i2 14 1 Some some DT cord-269353-wgeuh1i2 14 2 viruses virus NNS cord-269353-wgeuh1i2 14 3 can can MD cord-269353-wgeuh1i2 14 4 invade invade VB cord-269353-wgeuh1i2 14 5 a a DT cord-269353-wgeuh1i2 14 6 broad broad JJ cord-269353-wgeuh1i2 14 7 spectrum spectrum NN cord-269353-wgeuh1i2 14 8 of of IN cord-269353-wgeuh1i2 14 9 hosts host NNS cord-269353-wgeuh1i2 14 10 ( ( -LRB- cord-269353-wgeuh1i2 14 11 BSTVs bstv NNS cord-269353-wgeuh1i2 14 12 ) ) -RRB- cord-269353-wgeuh1i2 14 13 , , , cord-269353-wgeuh1i2 14 14 while while IN cord-269353-wgeuh1i2 14 15 others other NNS cord-269353-wgeuh1i2 14 16 can can MD cord-269353-wgeuh1i2 14 17 invade invade VB cord-269353-wgeuh1i2 14 18 a a DT cord-269353-wgeuh1i2 14 19 narrow narrow JJ cord-269353-wgeuh1i2 14 20 spectrum spectrum NN cord-269353-wgeuh1i2 14 21 only only RB cord-269353-wgeuh1i2 14 22 ( ( -LRB- cord-269353-wgeuh1i2 14 23 NSTVs nstv NNS cord-269353-wgeuh1i2 14 24 ) ) -RRB- cord-269353-wgeuh1i2 14 25 . . . cord-269353-wgeuh1i2 15 1 Consequently consequently RB cord-269353-wgeuh1i2 15 2 , , , cord-269353-wgeuh1i2 15 3 we -PRON- PRP cord-269353-wgeuh1i2 15 4 test test VBP cord-269353-wgeuh1i2 15 5 the the DT cord-269353-wgeuh1i2 15 6 hypothesis hypothesis NN cord-269353-wgeuh1i2 15 7 that that IN cord-269353-wgeuh1i2 15 8 similarity similarity NN cord-269353-wgeuh1i2 15 9 of of IN cord-269353-wgeuh1i2 15 10 codon codon NN cord-269353-wgeuh1i2 15 11 usage usage NN cord-269353-wgeuh1i2 15 12 preference preference NN cord-269353-wgeuh1i2 15 13 and and CC cord-269353-wgeuh1i2 15 14 the the DT cord-269353-wgeuh1i2 15 15 degree degree NN cord-269353-wgeuh1i2 15 16 of of IN cord-269353-wgeuh1i2 15 17 matching match VBG cord-269353-wgeuh1i2 15 18 between between IN cord-269353-wgeuh1i2 15 19 BSTVs bstv NNS cord-269353-wgeuh1i2 15 20 and and CC cord-269353-wgeuh1i2 15 21 their -PRON- PRP$ cord-269353-wgeuh1i2 15 22 hosts host NNS cord-269353-wgeuh1i2 15 23 will will MD cord-269353-wgeuh1i2 15 24 be be VB cord-269353-wgeuh1i2 15 25 lower low JJR cord-269353-wgeuh1i2 15 26 than than IN cord-269353-wgeuh1i2 15 27 that that DT cord-269353-wgeuh1i2 15 28 of of IN cord-269353-wgeuh1i2 15 29 NSTVs nstv NNS cord-269353-wgeuh1i2 15 30 , , , cord-269353-wgeuh1i2 15 31 which which WDT cord-269353-wgeuh1i2 15 32 only only RB cord-269353-wgeuh1i2 15 33 need need VBP cord-269353-wgeuh1i2 15 34 to to TO cord-269353-wgeuh1i2 15 35 coevolve coevolve VB cord-269353-wgeuh1i2 15 36 with with IN cord-269353-wgeuh1i2 15 37 few few JJ cord-269353-wgeuh1i2 15 38 hosts host NNS cord-269353-wgeuh1i2 15 39 . . . cord-269353-wgeuh1i2 16 1 We -PRON- PRP cord-269353-wgeuh1i2 16 2 compare compare VBP cord-269353-wgeuh1i2 16 3 the the DT cord-269353-wgeuh1i2 16 4 patterns pattern NNS cord-269353-wgeuh1i2 16 5 of of IN cord-269353-wgeuh1i2 16 6 codon codon NN cord-269353-wgeuh1i2 16 7 usage usage NN cord-269353-wgeuh1i2 16 8 in in IN cord-269353-wgeuh1i2 16 9 255 255 CD cord-269353-wgeuh1i2 16 10 virus virus NN cord-269353-wgeuh1i2 16 11 genomes genome NNS cord-269353-wgeuh1i2 16 12 to to TO cord-269353-wgeuh1i2 16 13 test test VB cord-269353-wgeuh1i2 16 14 this this DT cord-269353-wgeuh1i2 16 15 hypothesis hypothesis NN cord-269353-wgeuh1i2 16 16 . . . cord-269353-wgeuh1i2 17 1 Our -PRON- PRP$ cord-269353-wgeuh1i2 17 2 results result NNS cord-269353-wgeuh1i2 17 3 show show VBP cord-269353-wgeuh1i2 17 4 that that IN cord-269353-wgeuh1i2 17 5 NSTVs nstv NNS cord-269353-wgeuh1i2 17 6 have have VBP cord-269353-wgeuh1i2 17 7 a a DT cord-269353-wgeuh1i2 17 8 higher high JJR cord-269353-wgeuh1i2 17 9 degree degree NN cord-269353-wgeuh1i2 17 10 of of IN cord-269353-wgeuh1i2 17 11 matching match VBG cord-269353-wgeuh1i2 17 12 to to IN cord-269353-wgeuh1i2 17 13 their -PRON- PRP$ cord-269353-wgeuh1i2 17 14 hosts host NNS cord-269353-wgeuh1i2 17 15 ' ' POS cord-269353-wgeuh1i2 17 16 tRNA trna NN cord-269353-wgeuh1i2 17 17 pools pool NNS cord-269353-wgeuh1i2 17 18 than than IN cord-269353-wgeuh1i2 17 19 BSTVs bstv NNS cord-269353-wgeuh1i2 17 20 . . . cord-269353-wgeuh1i2 18 1 Further further RB cord-269353-wgeuh1i2 18 2 , , , cord-269353-wgeuh1i2 18 3 analysis analysis NN cord-269353-wgeuh1i2 18 4 of of IN cord-269353-wgeuh1i2 18 5 the the DT cord-269353-wgeuh1i2 18 6 effective effective JJ cord-269353-wgeuh1i2 18 7 number number NN cord-269353-wgeuh1i2 18 8 of of IN cord-269353-wgeuh1i2 18 9 codons codon NNS cord-269353-wgeuh1i2 18 10 ( ( -LRB- cord-269353-wgeuh1i2 18 11 ENC ENC NNP cord-269353-wgeuh1i2 18 12 ) ) -RRB- cord-269353-wgeuh1i2 18 13 infers infer VBZ cord-269353-wgeuh1i2 18 14 that that IN cord-269353-wgeuh1i2 18 15 codon codon NN cord-269353-wgeuh1i2 18 16 usage usage NN cord-269353-wgeuh1i2 18 17 bias bias NN cord-269353-wgeuh1i2 18 18 of of IN cord-269353-wgeuh1i2 18 19 NSTVs nstv NNS cord-269353-wgeuh1i2 18 20 is be VBZ cord-269353-wgeuh1i2 18 21 relatively relatively RB cord-269353-wgeuh1i2 18 22 stronger strong JJR cord-269353-wgeuh1i2 18 23 than than IN cord-269353-wgeuh1i2 18 24 that that DT cord-269353-wgeuh1i2 18 25 of of IN cord-269353-wgeuh1i2 18 26 BSTVs bstv NNS cord-269353-wgeuh1i2 18 27 . . . cord-269353-wgeuh1i2 19 1 Thus thus RB cord-269353-wgeuh1i2 19 2 , , , cord-269353-wgeuh1i2 19 3 codon codon NN cord-269353-wgeuh1i2 19 4 usage usage NN cord-269353-wgeuh1i2 19 5 of of IN cord-269353-wgeuh1i2 19 6 NSTVs nstv NNS cord-269353-wgeuh1i2 19 7 tends tend VBZ cord-269353-wgeuh1i2 19 8 to to TO cord-269353-wgeuh1i2 19 9 better better RB cord-269353-wgeuh1i2 19 10 match match VB cord-269353-wgeuh1i2 19 11 their -PRON- PRP$ cord-269353-wgeuh1i2 19 12 host host NN cord-269353-wgeuh1i2 19 13 than than IN cord-269353-wgeuh1i2 19 14 that that DT cord-269353-wgeuh1i2 19 15 of of IN cord-269353-wgeuh1i2 19 16 BSTVs bstv NNS cord-269353-wgeuh1i2 19 17 . . . cord-269353-wgeuh1i2 20 1 This this DT cord-269353-wgeuh1i2 20 2 supports support VBZ cord-269353-wgeuh1i2 20 3 the the DT cord-269353-wgeuh1i2 20 4 hypothesis hypothesis NN cord-269353-wgeuh1i2 20 5 that that WDT cord-269353-wgeuh1i2 20 6 viruses virus NNS cord-269353-wgeuh1i2 20 7 adapt adapt VBP cord-269353-wgeuh1i2 20 8 to to IN cord-269353-wgeuh1i2 20 9 the the DT cord-269353-wgeuh1i2 20 10 expression expression NN cord-269353-wgeuh1i2 20 11 system system NN cord-269353-wgeuh1i2 20 12 of of IN cord-269353-wgeuh1i2 20 13 their -PRON- PRP$ cord-269353-wgeuh1i2 20 14 host(s host(s NNP cord-269353-wgeuh1i2 20 15 ) ) -RRB- cord-269353-wgeuh1i2 20 16 . . . cord-269353-wgeuh1i2 21 1 Viruses virus NNS cord-269353-wgeuh1i2 21 2 are be VBP cord-269353-wgeuh1i2 21 3 pure pure JJ cord-269353-wgeuh1i2 21 4 parasites parasite NNS cord-269353-wgeuh1i2 21 5 . . . cord-269353-wgeuh1i2 22 1 They -PRON- PRP cord-269353-wgeuh1i2 22 2 depend depend VBP cord-269353-wgeuh1i2 22 3 on on IN cord-269353-wgeuh1i2 22 4 their -PRON- PRP$ cord-269353-wgeuh1i2 22 5 hosts host NNS cord-269353-wgeuh1i2 22 6 ' ' POS cord-269353-wgeuh1i2 22 7 cellular cellular JJ cord-269353-wgeuh1i2 22 8 structure structure NN cord-269353-wgeuh1i2 22 9 and and CC cord-269353-wgeuh1i2 22 10 metabolism metabolism NN cord-269353-wgeuh1i2 22 11 to to TO cord-269353-wgeuh1i2 22 12 replicate replicate VB cord-269353-wgeuh1i2 22 13 and and CC cord-269353-wgeuh1i2 22 14 assemble assemble VB cord-269353-wgeuh1i2 22 15 , , , cord-269353-wgeuh1i2 22 16 i.e. i.e. FW cord-269353-wgeuh1i2 22 17 , , , cord-269353-wgeuh1i2 22 18 survive survive VB cord-269353-wgeuh1i2 22 19 . . . cord-269353-wgeuh1i2 23 1 Most Most JJS cord-269353-wgeuh1i2 23 2 of of IN cord-269353-wgeuh1i2 23 3 their -PRON- PRP$ cord-269353-wgeuh1i2 23 4 genomes genome NNS cord-269353-wgeuh1i2 23 5 do do VBP cord-269353-wgeuh1i2 23 6 not not RB cord-269353-wgeuh1i2 23 7 encode encode VB cord-269353-wgeuh1i2 23 8 tRNAs trna NNS cord-269353-wgeuh1i2 23 9 , , , cord-269353-wgeuh1i2 23 10 thus thus RB cord-269353-wgeuh1i2 23 11 their -PRON- PRP$ cord-269353-wgeuh1i2 23 12 translation translation NN cord-269353-wgeuh1i2 23 13 of of IN cord-269353-wgeuh1i2 23 14 viral viral JJ cord-269353-wgeuh1i2 23 15 proteins protein NNS cord-269353-wgeuh1i2 23 16 relies rely VBZ cord-269353-wgeuh1i2 23 17 on on IN cord-269353-wgeuh1i2 23 18 the the DT cord-269353-wgeuh1i2 23 19 hosts host NNS cord-269353-wgeuh1i2 23 20 ' ' POS cord-269353-wgeuh1i2 23 21 tRNA trna NN cord-269353-wgeuh1i2 23 22 pools pool NNS cord-269353-wgeuh1i2 23 23 ( ( -LRB- cord-269353-wgeuh1i2 23 24 Kumar Kumar NNP cord-269353-wgeuh1i2 23 25 et et NNP cord-269353-wgeuh1i2 23 26 al al NNP cord-269353-wgeuh1i2 23 27 . . . cord-269353-wgeuh1i2 23 28 2016 2016 CD cord-269353-wgeuh1i2 23 29 ) ) -RRB- cord-269353-wgeuh1i2 23 30 . . . cord-269353-wgeuh1i2 24 1 A a DT cord-269353-wgeuh1i2 24 2 successful successful JJ cord-269353-wgeuh1i2 24 3 infection infection NN cord-269353-wgeuh1i2 24 4 requires require VBZ cord-269353-wgeuh1i2 24 5 that that IN cord-269353-wgeuh1i2 24 6 viruses virus NNS cord-269353-wgeuh1i2 24 7 possess possess VBP cord-269353-wgeuh1i2 24 8 the the DT cord-269353-wgeuh1i2 24 9 ability ability NN cord-269353-wgeuh1i2 24 10 to to TO cord-269353-wgeuh1i2 24 11 enter enter VB cord-269353-wgeuh1i2 24 12 the the DT cord-269353-wgeuh1i2 24 13 host host NN cord-269353-wgeuh1i2 24 14 cell cell NN cord-269353-wgeuh1i2 24 15 , , , cord-269353-wgeuh1i2 24 16 and and CC cord-269353-wgeuh1i2 24 17 efficiently efficiently RB cord-269353-wgeuh1i2 24 18 produce produce VB cord-269353-wgeuh1i2 24 19 new new JJ cord-269353-wgeuh1i2 24 20 viruses virus NNS cord-269353-wgeuh1i2 24 21 . . . cord-269353-wgeuh1i2 25 1 The the DT cord-269353-wgeuh1i2 25 2 degenerate degenerate JJ cord-269353-wgeuh1i2 25 3 genetic genetic JJ cord-269353-wgeuh1i2 25 4 code code NN cord-269353-wgeuh1i2 25 5 unequally unequally RB cord-269353-wgeuh1i2 25 6 uses use VBZ cord-269353-wgeuh1i2 25 7 synonymous synonymous JJ cord-269353-wgeuh1i2 25 8 codons codon NNS cord-269353-wgeuh1i2 25 9 , , , cord-269353-wgeuh1i2 25 10 which which WDT cord-269353-wgeuh1i2 25 11 code code NN cord-269353-wgeuh1i2 25 12 for for IN cord-269353-wgeuh1i2 25 13 the the DT cord-269353-wgeuh1i2 25 14 same same JJ cord-269353-wgeuh1i2 25 15 amino amino NN cord-269353-wgeuh1i2 25 16 acid acid NN cord-269353-wgeuh1i2 25 17 ( ( -LRB- cord-269353-wgeuh1i2 25 18 Cristina Cristina NNP cord-269353-wgeuh1i2 25 19 et et NNP cord-269353-wgeuh1i2 25 20 al al NNP cord-269353-wgeuh1i2 25 21 . . . cord-269353-wgeuh1i2 25 22 2016 2016 CD cord-269353-wgeuh1i2 25 23 ; ; : cord-269353-wgeuh1i2 25 24 Kanaya Kanaya NNP cord-269353-wgeuh1i2 25 25 et et NNP cord-269353-wgeuh1i2 25 26 al al NNP cord-269353-wgeuh1i2 25 27 . . . cord-269353-wgeuh1i2 26 1 2001 2001 CD cord-269353-wgeuh1i2 26 2 ; ; : cord-269353-wgeuh1i2 26 3 Shackelton Shackelton NNP cord-269353-wgeuh1i2 26 4 et et FW cord-269353-wgeuh1i2 26 5 al al NNP cord-269353-wgeuh1i2 26 6 . . . cord-269353-wgeuh1i2 27 1 2006 2006 CD cord-269353-wgeuh1i2 27 2 ; ; : cord-269353-wgeuh1i2 27 3 Tsai Tsai NNP cord-269353-wgeuh1i2 27 4 et et NNP cord-269353-wgeuh1i2 27 5 al al NNP cord-269353-wgeuh1i2 27 6 . . NNP cord-269353-wgeuh1i2 27 7 2007 2007 CD cord-269353-wgeuh1i2 27 8 ) ) -RRB- cord-269353-wgeuh1i2 27 9 . . . cord-269353-wgeuh1i2 28 1 The the DT cord-269353-wgeuh1i2 28 2 redundancy redundancy NN cord-269353-wgeuh1i2 28 3 of of IN cord-269353-wgeuh1i2 28 4 the the DT cord-269353-wgeuh1i2 28 5 genetic genetic JJ cord-269353-wgeuh1i2 28 6 code code NN cord-269353-wgeuh1i2 28 7 provides provide VBZ cord-269353-wgeuh1i2 28 8 the the DT cord-269353-wgeuh1i2 28 9 opportunity opportunity NN cord-269353-wgeuh1i2 28 10 to to TO cord-269353-wgeuh1i2 28 11 shape shape VB cord-269353-wgeuh1i2 28 12 the the DT cord-269353-wgeuh1i2 28 13 efficiency efficiency NN cord-269353-wgeuh1i2 28 14 and and CC cord-269353-wgeuh1i2 28 15 accuracy accuracy NN cord-269353-wgeuh1i2 28 16 of of IN cord-269353-wgeuh1i2 28 17 protein protein NN cord-269353-wgeuh1i2 28 18 production production NN cord-269353-wgeuh1i2 28 19 , , , cord-269353-wgeuh1i2 28 20 while while IN cord-269353-wgeuh1i2 28 21 maintaining maintain VBG cord-269353-wgeuh1i2 28 22 the the DT cord-269353-wgeuh1i2 28 23 same same JJ cord-269353-wgeuh1i2 28 24 amino amino NN cord-269353-wgeuh1i2 28 25 acid acid NN cord-269353-wgeuh1i2 28 26 sequence sequence NN cord-269353-wgeuh1i2 28 27 ( ( -LRB- cord-269353-wgeuh1i2 28 28 Chaney Chaney NNP cord-269353-wgeuh1i2 28 29 and and CC cord-269353-wgeuh1i2 28 30 Clark Clark NNP cord-269353-wgeuh1i2 28 31 2015 2015 CD cord-269353-wgeuh1i2 28 32 ; ; : cord-269353-wgeuh1i2 28 33 Plotkin Plotkin NNP cord-269353-wgeuh1i2 28 34 and and CC cord-269353-wgeuh1i2 28 35 Kudla Kudla NNP cord-269353-wgeuh1i2 28 36 2011 2011 CD cord-269353-wgeuh1i2 28 37 ; ; : cord-269353-wgeuh1i2 28 38 Stoletzki Stoletzki NNP cord-269353-wgeuh1i2 28 39 and and CC cord-269353-wgeuh1i2 28 40 Eyre Eyre NNP cord-269353-wgeuh1i2 28 41 - - HYPH cord-269353-wgeuh1i2 28 42 Walker Walker NNP cord-269353-wgeuh1i2 28 43 2007 2007 CD cord-269353-wgeuh1i2 28 44 ) ) -RRB- cord-269353-wgeuh1i2 28 45 . . . cord-269353-wgeuh1i2 29 1 Considering consider VBG cord-269353-wgeuh1i2 29 2 that that IN cord-269353-wgeuh1i2 29 3 the the DT cord-269353-wgeuh1i2 29 4 translation translation NN cord-269353-wgeuh1i2 29 5 of of IN cord-269353-wgeuh1i2 29 6 viral viral JJ cord-269353-wgeuh1i2 29 7 proteins protein NNS cord-269353-wgeuh1i2 29 8 relies rely VBZ cord-269353-wgeuh1i2 29 9 on on IN cord-269353-wgeuh1i2 29 10 the the DT cord-269353-wgeuh1i2 29 11 host host NN cord-269353-wgeuh1i2 29 12 's 's POS cord-269353-wgeuh1i2 29 13 pool pool NN cord-269353-wgeuh1i2 29 14 of of IN cord-269353-wgeuh1i2 29 15 tRNAs trna NNS cord-269353-wgeuh1i2 29 16 , , , cord-269353-wgeuh1i2 29 17 codon codon NN cord-269353-wgeuh1i2 29 18 usage usage NN cord-269353-wgeuh1i2 29 19 of of IN cord-269353-wgeuh1i2 29 20 a a DT cord-269353-wgeuh1i2 29 21 virus virus NN cord-269353-wgeuh1i2 29 22 must must MD cord-269353-wgeuh1i2 29 23 coevolve coevolve VB cord-269353-wgeuh1i2 29 24 with with IN cord-269353-wgeuh1i2 29 25 its -PRON- PRP$ cord-269353-wgeuh1i2 29 26 host host NN cord-269353-wgeuh1i2 29 27 to to TO cord-269353-wgeuh1i2 29 28 efficiently efficiently RB cord-269353-wgeuh1i2 29 29 use use VB cord-269353-wgeuh1i2 29 30 host host NN cord-269353-wgeuh1i2 29 31 resources resource NNS cord-269353-wgeuh1i2 29 32 . . . cord-269353-wgeuh1i2 30 1 It -PRON- PRP cord-269353-wgeuh1i2 30 2 is be VBZ cord-269353-wgeuh1i2 30 3 expected expect VBN cord-269353-wgeuh1i2 30 4 that that IN cord-269353-wgeuh1i2 30 5 higher high JJR cord-269353-wgeuh1i2 30 6 similarity similarity NN cord-269353-wgeuh1i2 30 7 of of IN cord-269353-wgeuh1i2 30 8 codon codon NN cord-269353-wgeuh1i2 30 9 usage usage NN cord-269353-wgeuh1i2 30 10 pattern pattern NN cord-269353-wgeuh1i2 30 11 will will MD cord-269353-wgeuh1i2 30 12 better better RB cord-269353-wgeuh1i2 30 13 facilitate facilitate VB cord-269353-wgeuh1i2 30 14 their -PRON- PRP$ cord-269353-wgeuh1i2 30 15 replication replication NN cord-269353-wgeuh1i2 30 16 . . . cord-269353-wgeuh1i2 31 1 The the DT cord-269353-wgeuh1i2 31 2 extent extent NN cord-269353-wgeuh1i2 31 3 of of IN cord-269353-wgeuh1i2 31 4 codon codon NN cord-269353-wgeuh1i2 31 5 usage usage NN cord-269353-wgeuh1i2 31 6 among among IN cord-269353-wgeuh1i2 31 7 viruses virus NNS cord-269353-wgeuh1i2 31 8 and and CC cord-269353-wgeuh1i2 31 9 their -PRON- PRP$ cord-269353-wgeuh1i2 31 10 hosts host NNS cord-269353-wgeuh1i2 31 11 has have VBZ cord-269353-wgeuh1i2 31 12 been be VBN cord-269353-wgeuh1i2 31 13 suggested suggest VBN cord-269353-wgeuh1i2 31 14 to to TO cord-269353-wgeuh1i2 31 15 affect affect VB cord-269353-wgeuh1i2 31 16 viral viral JJ cord-269353-wgeuh1i2 31 17 survival survival NN cord-269353-wgeuh1i2 31 18 , , , cord-269353-wgeuh1i2 31 19 fitness fitness NN cord-269353-wgeuh1i2 31 20 , , , cord-269353-wgeuh1i2 31 21 and and CC cord-269353-wgeuh1i2 31 22 evasion evasion NN cord-269353-wgeuh1i2 31 23 from from IN cord-269353-wgeuh1i2 31 24 host host NN cord-269353-wgeuh1i2 31 25 's 's POS cord-269353-wgeuh1i2 31 26 immune immune JJ cord-269353-wgeuh1i2 31 27 system system NN cord-269353-wgeuh1i2 31 28 ( ( -LRB- cord-269353-wgeuh1i2 31 29 Burns Burns NNP cord-269353-wgeuh1i2 31 30 et et NNP cord-269353-wgeuh1i2 31 31 al al NNP cord-269353-wgeuh1i2 31 32 . . . cord-269353-wgeuh1i2 31 33 2006 2006 CD cord-269353-wgeuh1i2 32 1 ; ; : cord-269353-wgeuh1i2 32 2 Costafreda Costafreda NNP cord-269353-wgeuh1i2 32 3 et et NNP cord-269353-wgeuh1i2 32 4 al al NNP cord-269353-wgeuh1i2 32 5 . . . cord-269353-wgeuh1i2 33 1 2014 2014 CD cord-269353-wgeuh1i2 33 2 ; ; : cord-269353-wgeuh1i2 33 3 Mueller Mueller NNP cord-269353-wgeuh1i2 33 4 et et NNP cord-269353-wgeuh1i2 33 5 al al NNP cord-269353-wgeuh1i2 33 6 . . . cord-269353-wgeuh1i2 33 7 2006 2006 CD cord-269353-wgeuh1i2 33 8 ) ) -RRB- cord-269353-wgeuh1i2 33 9 . . . cord-269353-wgeuh1i2 34 1 Because because IN cord-269353-wgeuh1i2 34 2 the the DT cord-269353-wgeuh1i2 34 3 virus virus NN cord-269353-wgeuh1i2 34 4 relies rely VBZ cord-269353-wgeuh1i2 34 5 on on IN cord-269353-wgeuh1i2 34 6 the the DT cord-269353-wgeuh1i2 34 7 host host NN cord-269353-wgeuh1i2 34 8 's 's POS cord-269353-wgeuh1i2 34 9 cellular cellular JJ cord-269353-wgeuh1i2 34 10 machinery machinery NN cord-269353-wgeuh1i2 34 11 for for IN cord-269353-wgeuh1i2 34 12 its -PRON- PRP$ cord-269353-wgeuh1i2 34 13 replication replication NN cord-269353-wgeuh1i2 34 14 , , , cord-269353-wgeuh1i2 34 15 codon codon NN cord-269353-wgeuh1i2 34 16 usage usage NN cord-269353-wgeuh1i2 34 17 bias bias NN cord-269353-wgeuh1i2 34 18 was be VBD cord-269353-wgeuh1i2 34 19 suggested suggest VBN cord-269353-wgeuh1i2 34 20 to to TO cord-269353-wgeuh1i2 34 21 play play VB cord-269353-wgeuh1i2 34 22 a a DT cord-269353-wgeuh1i2 34 23 role role NN cord-269353-wgeuh1i2 34 24 in in IN cord-269353-wgeuh1i2 34 25 the the DT cord-269353-wgeuh1i2 34 26 adaptation adaptation NN cord-269353-wgeuh1i2 34 27 of of IN cord-269353-wgeuh1i2 34 28 a a DT cord-269353-wgeuh1i2 34 29 virus virus NN cord-269353-wgeuh1i2 34 30 to to IN cord-269353-wgeuh1i2 34 31 its -PRON- PRP$ cord-269353-wgeuh1i2 34 32 host host NN cord-269353-wgeuh1i2 34 33 . . . cord-269353-wgeuh1i2 35 1 Codon codon NN cord-269353-wgeuh1i2 35 2 usage usage NN cord-269353-wgeuh1i2 35 3 bias bias NN cord-269353-wgeuh1i2 35 4 is be VBZ cord-269353-wgeuh1i2 35 5 common common JJ cord-269353-wgeuh1i2 35 6 in in IN cord-269353-wgeuh1i2 35 7 viruses virus NNS cord-269353-wgeuh1i2 36 1 ( ( -LRB- cord-269353-wgeuh1i2 36 2 Butt Butt NNP cord-269353-wgeuh1i2 36 3 et et FW cord-269353-wgeuh1i2 36 4 al al NNP cord-269353-wgeuh1i2 36 5 . . . cord-269353-wgeuh1i2 37 1 2014 2014 CD cord-269353-wgeuh1i2 37 2 ; ; : cord-269353-wgeuh1i2 37 3 Castells Castells NNP cord-269353-wgeuh1i2 37 4 et et NNP cord-269353-wgeuh1i2 37 5 al al NNP cord-269353-wgeuh1i2 37 6 . . . cord-269353-wgeuh1i2 37 7 2017 2017 CD cord-269353-wgeuh1i2 38 1 ; ; : cord-269353-wgeuh1i2 38 2 Cristina Cristina NNP cord-269353-wgeuh1i2 38 3 et et NNP cord-269353-wgeuh1i2 38 4 al al NNP cord-269353-wgeuh1i2 38 5 . . . cord-269353-wgeuh1i2 38 6 2016 2016 CD cord-269353-wgeuh1i2 39 1 ; ; : cord-269353-wgeuh1i2 39 2 He -PRON- PRP cord-269353-wgeuh1i2 39 3 et et FW cord-269353-wgeuh1i2 39 4 al al NNP cord-269353-wgeuh1i2 39 5 . . . cord-269353-wgeuh1i2 39 6 2017 2017 CD cord-269353-wgeuh1i2 40 1 ; ; : cord-269353-wgeuh1i2 40 2 Li Li NNP cord-269353-wgeuh1i2 40 3 et et NNP cord-269353-wgeuh1i2 40 4 al al NNP cord-269353-wgeuh1i2 40 5 . . . cord-269353-wgeuh1i2 40 6 2017 2017 CD cord-269353-wgeuh1i2 41 1 ; ; : cord-269353-wgeuh1i2 41 2 Moratorio Moratorio NNP cord-269353-wgeuh1i2 41 3 et et NNP cord-269353-wgeuh1i2 41 4 al al NNP cord-269353-wgeuh1i2 41 5 . . . cord-269353-wgeuh1i2 42 1 2013 2013 CD cord-269353-wgeuh1i2 42 2 ; ; : cord-269353-wgeuh1i2 42 3 Singh Singh NNP cord-269353-wgeuh1i2 42 4 et et NNP cord-269353-wgeuh1i2 42 5 al al NNP cord-269353-wgeuh1i2 42 6 . . . cord-269353-wgeuh1i2 42 7 2016 2016 CD cord-269353-wgeuh1i2 42 8 ; ; . cord-269353-wgeuh1i2 43 1 Su Su NNP cord-269353-wgeuh1i2 43 2 et et FW cord-269353-wgeuh1i2 43 3 al al NNP cord-269353-wgeuh1i2 43 4 . . . cord-269353-wgeuh1i2 43 5 2017 2017 CD cord-269353-wgeuh1i2 44 1 ; ; : cord-269353-wgeuh1i2 44 2 Xu Xu NNP cord-269353-wgeuh1i2 44 3 et et NNP cord-269353-wgeuh1i2 44 4 al al NNP cord-269353-wgeuh1i2 44 5 . . . cord-269353-wgeuh1i2 44 6 2017 2017 CD cord-269353-wgeuh1i2 45 1 ; ; : cord-269353-wgeuh1i2 45 2 Zang Zang NNP cord-269353-wgeuh1i2 45 3 et et NNP cord-269353-wgeuh1i2 45 4 al al NNP cord-269353-wgeuh1i2 45 5 . . . cord-269353-wgeuh1i2 45 6 2017 2017 CD cord-269353-wgeuh1i2 46 1 ; ; : cord-269353-wgeuh1i2 46 2 Zhao Zhao NNP cord-269353-wgeuh1i2 46 3 et et NNP cord-269353-wgeuh1i2 46 4 al al NNP cord-269353-wgeuh1i2 46 5 . . . cord-269353-wgeuh1i2 46 6 2016 2016 CD cord-269353-wgeuh1i2 46 7 ) ) -RRB- cord-269353-wgeuh1i2 46 8 . . . cord-269353-wgeuh1i2 47 1 Efficient efficient JJ cord-269353-wgeuh1i2 47 2 replication replication NN cord-269353-wgeuh1i2 47 3 seemingly seemingly RB cord-269353-wgeuh1i2 47 4 requires require VBZ cord-269353-wgeuh1i2 47 5 that that IN cord-269353-wgeuh1i2 47 6 a a DT cord-269353-wgeuh1i2 47 7 virus virus NN cord-269353-wgeuh1i2 47 8 and and CC cord-269353-wgeuh1i2 47 9 host host NN cord-269353-wgeuh1i2 47 10 have have VBP cord-269353-wgeuh1i2 47 11 similar similar JJ cord-269353-wgeuh1i2 47 12 codon codon NN cord-269353-wgeuh1i2 47 13 usage usage NN cord-269353-wgeuh1i2 47 14 patterns pattern NNS cord-269353-wgeuh1i2 47 15 to to TO cord-269353-wgeuh1i2 47 16 share share VB cord-269353-wgeuh1i2 47 17 a a DT cord-269353-wgeuh1i2 47 18 tRNA tRNA NNP cord-269353-wgeuh1i2 47 19 pool pool NN cord-269353-wgeuh1i2 47 20 . . . cord-269353-wgeuh1i2 48 1 Co co NN cord-269353-wgeuh1i2 48 2 - - NN cord-269353-wgeuh1i2 48 3 evolution evolution NN cord-269353-wgeuh1i2 48 4 between between IN cord-269353-wgeuh1i2 48 5 a a DT cord-269353-wgeuh1i2 48 6 certain certain JJ cord-269353-wgeuh1i2 48 7 RNA RNA NNP cord-269353-wgeuh1i2 48 8 virus virus NN cord-269353-wgeuh1i2 48 9 and and CC cord-269353-wgeuh1i2 48 10 its -PRON- PRP$ cord-269353-wgeuh1i2 48 11 susceptible susceptible JJ cord-269353-wgeuh1i2 48 12 hosts host NNS cord-269353-wgeuh1i2 48 13 at at IN cord-269353-wgeuh1i2 48 14 codon codon NN cord-269353-wgeuh1i2 48 15 usages usage NNS cord-269353-wgeuh1i2 48 16 have have VBP cord-269353-wgeuh1i2 48 17 been be VBN cord-269353-wgeuh1i2 48 18 observed observe VBN cord-269353-wgeuh1i2 48 19 in in IN cord-269353-wgeuh1i2 48 20 many many JJ cord-269353-wgeuh1i2 48 21 viruses virus NNS cord-269353-wgeuh1i2 48 22 ( ( -LRB- cord-269353-wgeuh1i2 48 23 Franzo Franzo NNP cord-269353-wgeuh1i2 48 24 et et NNP cord-269353-wgeuh1i2 48 25 al al NNP cord-269353-wgeuh1i2 48 26 . . . cord-269353-wgeuh1i2 48 27 2017 2017 CD cord-269353-wgeuh1i2 48 28 ; ; : cord-269353-wgeuh1i2 48 29 Rahman Rahman NNP cord-269353-wgeuh1i2 48 30 et et NNP cord-269353-wgeuh1i2 48 31 al al NNP cord-269353-wgeuh1i2 48 32 . . . cord-269353-wgeuh1i2 48 33 2017 2017 CD cord-269353-wgeuh1i2 48 34 ; ; : cord-269353-wgeuh1i2 48 35 Simón Simón NNP cord-269353-wgeuh1i2 48 36 et et NNP cord-269353-wgeuh1i2 48 37 al al NNP cord-269353-wgeuh1i2 48 38 . . . cord-269353-wgeuh1i2 48 39 2017 2017 CD cord-269353-wgeuh1i2 48 40 ) ) -RRB- cord-269353-wgeuh1i2 48 41 . . . cord-269353-wgeuh1i2 49 1 Some some DT cord-269353-wgeuh1i2 49 2 viruses virus NNS cord-269353-wgeuh1i2 49 3 have have VBP cord-269353-wgeuh1i2 49 4 a a DT cord-269353-wgeuh1i2 49 5 broad broad JJ cord-269353-wgeuh1i2 49 6 ranges range NNS cord-269353-wgeuh1i2 49 7 of of IN cord-269353-wgeuh1i2 49 8 hosts host NNS cord-269353-wgeuh1i2 49 9 ( ( -LRB- cord-269353-wgeuh1i2 49 10 BSTVs bstv NNS cord-269353-wgeuh1i2 49 11 ) ) -RRB- cord-269353-wgeuh1i2 49 12 , , , cord-269353-wgeuh1i2 49 13 such such JJ cord-269353-wgeuh1i2 49 14 as as IN cord-269353-wgeuh1i2 49 15 arbovirus arbovirus NNP cord-269353-wgeuh1i2 49 16 . . . cord-269353-wgeuh1i2 50 1 These these DT cord-269353-wgeuh1i2 50 2 can can MD cord-269353-wgeuh1i2 50 3 infect infect VB cord-269353-wgeuh1i2 50 4 mammals mammal NNS cord-269353-wgeuh1i2 50 5 , , , cord-269353-wgeuh1i2 50 6 birds bird NNS cord-269353-wgeuh1i2 50 7 , , , cord-269353-wgeuh1i2 50 8 and and CC cord-269353-wgeuh1i2 50 9 insects insect NNS cord-269353-wgeuh1i2 50 10 . . . cord-269353-wgeuh1i2 51 1 Other other JJ cord-269353-wgeuh1i2 51 2 viruses virus NNS cord-269353-wgeuh1i2 51 3 have have VBP cord-269353-wgeuh1i2 51 4 narrow narrow JJ cord-269353-wgeuh1i2 51 5 host host NN cord-269353-wgeuh1i2 51 6 ranges range NNS cord-269353-wgeuh1i2 51 7 ( ( -LRB- cord-269353-wgeuh1i2 51 8 NSTVs nstv NNS cord-269353-wgeuh1i2 51 9 ) ) -RRB- cord-269353-wgeuh1i2 51 10 , , , cord-269353-wgeuh1i2 51 11 which which WDT cord-269353-wgeuh1i2 51 12 can can MD cord-269353-wgeuh1i2 51 13 infect infect VB cord-269353-wgeuh1i2 51 14 a a DT cord-269353-wgeuh1i2 51 15 limited limited JJ cord-269353-wgeuh1i2 51 16 number number NN cord-269353-wgeuh1i2 51 17 of of IN cord-269353-wgeuh1i2 51 18 hosts host NNS cord-269353-wgeuh1i2 51 19 only only RB cord-269353-wgeuh1i2 51 20 . . . cord-269353-wgeuh1i2 52 1 Because because IN cord-269353-wgeuh1i2 52 2 BSTVs bstv NNS cord-269353-wgeuh1i2 52 3 must must MD cord-269353-wgeuh1i2 52 4 fit fit VB cord-269353-wgeuh1i2 52 5 to to IN cord-269353-wgeuh1i2 52 6 multiple multiple JJ cord-269353-wgeuh1i2 52 7 hosts host NNS cord-269353-wgeuh1i2 52 8 and and CC cord-269353-wgeuh1i2 52 9 their -PRON- PRP$ cord-269353-wgeuh1i2 52 10 diverse diverse JJ cord-269353-wgeuh1i2 52 11 tRNA trna NN cord-269353-wgeuh1i2 52 12 pools pool NNS cord-269353-wgeuh1i2 52 13 and and CC cord-269353-wgeuh1i2 52 14 their -PRON- PRP$ cord-269353-wgeuh1i2 52 15 codon codon NN cord-269353-wgeuh1i2 52 16 usage usage NN cord-269353-wgeuh1i2 52 17 has have VBZ cord-269353-wgeuh1i2 52 18 a a DT cord-269353-wgeuh1i2 52 19 relationship relationship NN cord-269353-wgeuh1i2 52 20 with with IN cord-269353-wgeuh1i2 52 21 their -PRON- PRP$ cord-269353-wgeuh1i2 52 22 host host NN cord-269353-wgeuh1i2 52 23 , , , cord-269353-wgeuh1i2 52 24 a a DT cord-269353-wgeuh1i2 52 25 tradeoff tradeoff NN cord-269353-wgeuh1i2 52 26 exists exist VBZ cord-269353-wgeuh1i2 52 27 regarding regard VBG cord-269353-wgeuh1i2 52 28 the the DT cord-269353-wgeuh1i2 52 29 extent extent NN cord-269353-wgeuh1i2 52 30 of of IN cord-269353-wgeuh1i2 52 31 codon codon NN cord-269353-wgeuh1i2 52 32 usage usage NN cord-269353-wgeuh1i2 52 33 . . . cord-269353-wgeuh1i2 53 1 BSTVs bstv NNS cord-269353-wgeuh1i2 53 2 must must MD cord-269353-wgeuh1i2 53 3 fit fit VB cord-269353-wgeuh1i2 53 4 to to IN cord-269353-wgeuh1i2 53 5 their -PRON- PRP$ cord-269353-wgeuh1i2 53 6 diverse diverse JJ cord-269353-wgeuh1i2 53 7 hosts host NNS cord-269353-wgeuh1i2 53 8 and and CC cord-269353-wgeuh1i2 53 9 , , , cord-269353-wgeuh1i2 53 10 thus thus RB cord-269353-wgeuh1i2 53 11 , , , cord-269353-wgeuh1i2 53 12 the the DT cord-269353-wgeuh1i2 53 13 extent extent NN cord-269353-wgeuh1i2 53 14 of of IN cord-269353-wgeuh1i2 53 15 matching match VBG cord-269353-wgeuh1i2 53 16 for for IN cord-269353-wgeuh1i2 53 17 codon codon NN cord-269353-wgeuh1i2 53 18 usage usage NN cord-269353-wgeuh1i2 53 19 would would MD cord-269353-wgeuh1i2 53 20 be be VB cord-269353-wgeuh1i2 53 21 lower low JJR cord-269353-wgeuh1i2 53 22 than than IN cord-269353-wgeuh1i2 53 23 that that DT cord-269353-wgeuh1i2 53 24 of of IN cord-269353-wgeuh1i2 53 25 NSTVs nstv NNS cord-269353-wgeuh1i2 53 26 , , , cord-269353-wgeuh1i2 53 27 which which WDT cord-269353-wgeuh1i2 53 28 must must MD cord-269353-wgeuh1i2 53 29 fit fit VB cord-269353-wgeuh1i2 53 30 few few JJ cord-269353-wgeuh1i2 53 31 , , , cord-269353-wgeuh1i2 53 32 similar similar JJ cord-269353-wgeuh1i2 53 33 hosts host NNS cord-269353-wgeuh1i2 53 34 . . . cord-269353-wgeuh1i2 54 1 To to TO cord-269353-wgeuh1i2 54 2 test test VB cord-269353-wgeuh1i2 54 3 this this DT cord-269353-wgeuh1i2 54 4 hypothesis hypothesis NN cord-269353-wgeuh1i2 54 5 , , , cord-269353-wgeuh1i2 54 6 we -PRON- PRP cord-269353-wgeuh1i2 54 7 analyze analyze VBP cord-269353-wgeuh1i2 54 8 255 255 CD cord-269353-wgeuh1i2 54 9 viruses virus NNS cord-269353-wgeuh1i2 54 10 from from IN cord-269353-wgeuh1i2 54 11 20 20 CD cord-269353-wgeuh1i2 54 12 genera genus NNS cord-269353-wgeuh1i2 54 13 of of IN cord-269353-wgeuh1i2 54 14 positivesense positivesense NN cord-269353-wgeuh1i2 54 15 single single RB cord-269353-wgeuh1i2 54 16 - - HYPH cord-269353-wgeuh1i2 54 17 stranded strand VBN cord-269353-wgeuh1i2 54 18 RNA RNA NNP cord-269353-wgeuh1i2 54 19 ( ( -LRB- cord-269353-wgeuh1i2 54 20 + + CC cord-269353-wgeuh1i2 54 21 ssRNA ssrna NN cord-269353-wgeuh1i2 54 22 ) ) -RRB- cord-269353-wgeuh1i2 54 23 viruses virus NNS cord-269353-wgeuh1i2 54 24 ( ( -LRB- cord-269353-wgeuh1i2 54 25 e.g. e.g. RB cord-269353-wgeuh1i2 54 26 , , , cord-269353-wgeuh1i2 54 27 Flavivirus Flavivirus NNP cord-269353-wgeuh1i2 54 28 , , , cord-269353-wgeuh1i2 54 29 Alphavirus Alphavirus NNP cord-269353-wgeuh1i2 54 30 , , , cord-269353-wgeuh1i2 54 31 Coronavirus Coronavirus NNP cord-269353-wgeuh1i2 54 32 , , , cord-269353-wgeuh1i2 54 33 Torovirus Torovirus NNP cord-269353-wgeuh1i2 54 34 , , , cord-269353-wgeuh1i2 54 35 Arterivirus Arterivirus NNP cord-269353-wgeuh1i2 54 36 , , , cord-269353-wgeuh1i2 54 37 Rubivirus Rubivirus NNP cord-269353-wgeuh1i2 54 38 , , , cord-269353-wgeuh1i2 54 39 Pestivirus Pestivirus NNP cord-269353-wgeuh1i2 54 40 , , , cord-269353-wgeuh1i2 54 41 Hepacivirus Hepacivirus NNP cord-269353-wgeuh1i2 54 42 , , , cord-269353-wgeuh1i2 54 43 Alphamesonivirus Alphamesonivirus NNP cord-269353-wgeuh1i2 54 44 ) ) -RRB- cord-269353-wgeuh1i2 54 45 . . . cord-269353-wgeuh1i2 55 1 Viruses virus NNS cord-269353-wgeuh1i2 55 2 that that WDT cord-269353-wgeuh1i2 55 3 can can MD cord-269353-wgeuh1i2 55 4 infect infect VB cord-269353-wgeuh1i2 55 5 vertebrates vertebrate NNS cord-269353-wgeuh1i2 55 6 and and CC cord-269353-wgeuh1i2 55 7 invertebrates invertebrate NNS cord-269353-wgeuh1i2 55 8 , , , cord-269353-wgeuh1i2 55 9 such such JJ cord-269353-wgeuh1i2 55 10 as as IN cord-269353-wgeuh1i2 55 11 most most JJS cord-269353-wgeuh1i2 55 12 of of IN cord-269353-wgeuh1i2 55 13 the the DT cord-269353-wgeuh1i2 55 14 Flavivirus Flavivirus NNP cord-269353-wgeuh1i2 55 15 and and CC cord-269353-wgeuh1i2 55 16 Alphavirus Alphavirus NNP cord-269353-wgeuh1i2 55 17 , , , cord-269353-wgeuh1i2 55 18 were be VBD cord-269353-wgeuh1i2 55 19 classified classify VBN cord-269353-wgeuh1i2 55 20 as as IN cord-269353-wgeuh1i2 55 21 BSTVs bstv NNS cord-269353-wgeuh1i2 55 22 , , , cord-269353-wgeuh1i2 55 23 while while IN cord-269353-wgeuh1i2 55 24 other other JJ cord-269353-wgeuh1i2 55 25 viruses virus NNS cord-269353-wgeuh1i2 55 26 that that WDT cord-269353-wgeuh1i2 55 27 can can MD cord-269353-wgeuh1i2 55 28 infect infect VB cord-269353-wgeuh1i2 55 29 either either DT cord-269353-wgeuh1i2 55 30 vertebrate vertebrate JJ cord-269353-wgeuh1i2 55 31 or or CC cord-269353-wgeuh1i2 55 32 invertebrate invertebrate NN cord-269353-wgeuh1i2 55 33 were be VBD cord-269353-wgeuh1i2 55 34 classified classify VBN cord-269353-wgeuh1i2 55 35 as as IN cord-269353-wgeuh1i2 55 36 NSTVs nstv NNS cord-269353-wgeuh1i2 55 37 . . . cord-269353-wgeuh1i2 56 1 The the DT cord-269353-wgeuh1i2 56 2 complete complete JJ cord-269353-wgeuh1i2 56 3 genome genome NN cord-269353-wgeuh1i2 56 4 sequences sequence NNS cord-269353-wgeuh1i2 56 5 of of IN cord-269353-wgeuh1i2 56 6 255 255 CD cord-269353-wgeuh1i2 56 7 virus virus NN cord-269353-wgeuh1i2 56 8 strains strain NNS cord-269353-wgeuh1i2 56 9 from from IN cord-269353-wgeuh1i2 56 10 the the DT cord-269353-wgeuh1i2 56 11 20 20 CD cord-269353-wgeuh1i2 56 12 genera genus NNS cord-269353-wgeuh1i2 56 13 of of IN cord-269353-wgeuh1i2 56 14 + + CD cord-269353-wgeuh1i2 56 15 ssRNA ssrna NN cord-269353-wgeuh1i2 57 1 viruses virus NNS cord-269353-wgeuh1i2 57 2 were be VBD cord-269353-wgeuh1i2 57 3 obtained obtain VBN cord-269353-wgeuh1i2 57 4 from from IN cord-269353-wgeuh1i2 57 5 the the DT cord-269353-wgeuh1i2 57 6 GenBank GenBank NNP cord-269353-wgeuh1i2 57 7 database database NN cord-269353-wgeuh1i2 57 8 ( ( -LRB- cord-269353-wgeuh1i2 57 9 http://www.ncbi.nlm.nih.gov http://www.ncbi.nlm.nih.gov NN cord-269353-wgeuh1i2 57 10 ) ) -RRB- cord-269353-wgeuh1i2 57 11 . . . cord-269353-wgeuh1i2 58 1 The the DT cord-269353-wgeuh1i2 58 2 information information NN cord-269353-wgeuh1i2 58 3 of of IN cord-269353-wgeuh1i2 58 4 host host NN cord-269353-wgeuh1i2 58 5 range range NN cord-269353-wgeuh1i2 58 6 was be VBD cord-269353-wgeuh1i2 58 7 determined determine VBN cord-269353-wgeuh1i2 58 8 from from IN cord-269353-wgeuh1i2 58 9 NCBI NCBI NNP cord-269353-wgeuh1i2 58 10 ( ( -LRB- cord-269353-wgeuh1i2 58 11 https://www.ncbi.nlm.nih.gov/taxonomy/ https://www.ncbi.nlm.nih.gov/taxonomy/ NNP cord-269353-wgeuh1i2 58 12 ) ) -RRB- cord-269353-wgeuh1i2 58 13 and and CC cord-269353-wgeuh1i2 58 14 the the DT cord-269353-wgeuh1i2 58 15 Ninth Ninth NNP cord-269353-wgeuh1i2 58 16 Report Report NNP cord-269353-wgeuh1i2 58 17 of of IN cord-269353-wgeuh1i2 58 18 the the DT cord-269353-wgeuh1i2 58 19 International International NNP cord-269353-wgeuh1i2 58 20 Committee Committee NNP cord-269353-wgeuh1i2 58 21 on on IN cord-269353-wgeuh1i2 58 22 Taxonomy Taxonomy NNP cord-269353-wgeuh1i2 58 23 of of IN cord-269353-wgeuh1i2 58 24 Viruses Viruses NNPS cord-269353-wgeuh1i2 59 1 ( ( -LRB- cord-269353-wgeuh1i2 59 2 ViralZone ViralZone NNP cord-269353-wgeuh1i2 59 3 Database Database NNP cord-269353-wgeuh1i2 59 4 : : : cord-269353-wgeuh1i2 59 5 http://viralzone.expasy.org/ http://viralzone.expasy.org/ ADD cord-269353-wgeuh1i2 59 6 ) ) -RRB- cord-269353-wgeuh1i2 59 7 . . . cord-269353-wgeuh1i2 60 1 Accession accession NN cord-269353-wgeuh1i2 60 2 numbers number NNS cord-269353-wgeuh1i2 60 3 and and CC cord-269353-wgeuh1i2 60 4 other other JJ cord-269353-wgeuh1i2 60 5 detailed detailed JJ cord-269353-wgeuh1i2 60 6 information information NN cord-269353-wgeuh1i2 60 7 of of IN cord-269353-wgeuh1i2 60 8 these these DT cord-269353-wgeuh1i2 60 9 viruses virus NNS cord-269353-wgeuh1i2 60 10 , , , cord-269353-wgeuh1i2 60 11 such such JJ cord-269353-wgeuh1i2 60 12 as as IN cord-269353-wgeuh1i2 60 13 strain strain NN cord-269353-wgeuh1i2 60 14 names name NNS cord-269353-wgeuh1i2 60 15 , , , cord-269353-wgeuh1i2 60 16 isolate isolate VB cord-269353-wgeuh1i2 60 17 hosts host NNS cord-269353-wgeuh1i2 60 18 and and CC cord-269353-wgeuh1i2 60 19 host host NN cord-269353-wgeuh1i2 60 20 ranges range NNS cord-269353-wgeuh1i2 60 21 were be VBD cord-269353-wgeuh1i2 60 22 also also RB cord-269353-wgeuh1i2 60 23 retrieved retrieve VBN cord-269353-wgeuh1i2 60 24 ( ( -LRB- cord-269353-wgeuh1i2 60 25 Supplementary Supplementary NNP cord-269353-wgeuh1i2 60 26 Table Table NNP cord-269353-wgeuh1i2 60 27 1 1 CD cord-269353-wgeuh1i2 60 28 ) ) -RRB- cord-269353-wgeuh1i2 60 29 . . . cord-269353-wgeuh1i2 61 1 Estimates estimate NNS cord-269353-wgeuh1i2 61 2 of of IN cord-269353-wgeuh1i2 61 3 codon codon NN cord-269353-wgeuh1i2 61 4 usage usage NN cord-269353-wgeuh1i2 61 5 , , , cord-269353-wgeuh1i2 61 6 the the DT cord-269353-wgeuh1i2 61 7 relative relative JJ cord-269353-wgeuh1i2 61 8 synonymous synonymous JJ cord-269353-wgeuh1i2 61 9 codon codon NN cord-269353-wgeuh1i2 61 10 usage usage NN cord-269353-wgeuh1i2 61 11 ( ( -LRB- cord-269353-wgeuh1i2 61 12 RSCU RSCU NNP cord-269353-wgeuh1i2 61 13 ) ) -RRB- cord-269353-wgeuh1i2 62 1 ( ( -LRB- cord-269353-wgeuh1i2 62 2 Sharp Sharp NNP cord-269353-wgeuh1i2 62 3 and and CC cord-269353-wgeuh1i2 62 4 Li Li NNP cord-269353-wgeuh1i2 62 5 1986 1986 CD cord-269353-wgeuh1i2 62 6 ) ) -RRB- cord-269353-wgeuh1i2 62 7 , , , cord-269353-wgeuh1i2 62 8 and and CC cord-269353-wgeuh1i2 62 9 the the DT cord-269353-wgeuh1i2 62 10 effective effective JJ cord-269353-wgeuh1i2 62 11 number number NN cord-269353-wgeuh1i2 62 12 of of IN cord-269353-wgeuh1i2 62 13 codons codon NNS cord-269353-wgeuh1i2 62 14 ( ( -LRB- cord-269353-wgeuh1i2 62 15 ENC ENC NNP cord-269353-wgeuh1i2 62 16 ) ) -RRB- cord-269353-wgeuh1i2 62 17 ( ( -LRB- cord-269353-wgeuh1i2 62 18 Wright Wright NNP cord-269353-wgeuh1i2 62 19 1990 1990 CD cord-269353-wgeuh1i2 62 20 ) ) -RRB- cord-269353-wgeuh1i2 62 21 , , , cord-269353-wgeuh1i2 62 22 were be VBD cord-269353-wgeuh1i2 62 23 calculated calculate VBN cord-269353-wgeuh1i2 62 24 using use VBG cord-269353-wgeuh1i2 62 25 CodonW codonw NN cord-269353-wgeuh1i2 62 26 ( ( -LRB- cord-269353-wgeuh1i2 62 27 available available JJ cord-269353-wgeuh1i2 62 28 at at IN cord-269353-wgeuh1i2 62 29 http:// http:// NNP cord-269353-wgeuh1i2 62 30 sourceforge.net/projects/codonw sourceforge.net/projects/codonw NNP cord-269353-wgeuh1i2 62 31 ) ) -RRB- cord-269353-wgeuh1i2 62 32 . . . cord-269353-wgeuh1i2 63 1 In in IN cord-269353-wgeuh1i2 63 2 this this DT cord-269353-wgeuh1i2 63 3 study study NN cord-269353-wgeuh1i2 63 4 , , , cord-269353-wgeuh1i2 63 5 Aedes Aedes NNP cord-269353-wgeuh1i2 63 6 , , , cord-269353-wgeuh1i2 63 7 Culex Culex NNP cord-269353-wgeuh1i2 63 8 and and CC cord-269353-wgeuh1i2 63 9 Ixodes Ixodes NNP cord-269353-wgeuh1i2 63 10 represented represent VBD cord-269353-wgeuh1i2 63 11 the the DT cord-269353-wgeuh1i2 63 12 main main JJ cord-269353-wgeuh1i2 63 13 arthropod arthropod JJ cord-269353-wgeuh1i2 63 14 hosts host NNS cord-269353-wgeuh1i2 63 15 , , , cord-269353-wgeuh1i2 63 16 and and CC cord-269353-wgeuh1i2 63 17 Gallus Gallus NNP cord-269353-wgeuh1i2 63 18 , , , cord-269353-wgeuh1i2 63 19 Homo Homo NNP cord-269353-wgeuh1i2 63 20 and and CC cord-269353-wgeuh1i2 63 21 Mus Mus NNP cord-269353-wgeuh1i2 63 22 the the DT cord-269353-wgeuh1i2 63 23 three three CD cord-269353-wgeuh1i2 63 24 major major JJ cord-269353-wgeuh1i2 63 25 groups group NNS cord-269353-wgeuh1i2 63 26 of of IN cord-269353-wgeuh1i2 63 27 vertebrates vertebrate NNS cord-269353-wgeuh1i2 63 28 . . . cord-269353-wgeuh1i2 64 1 Coding coding NN cord-269353-wgeuh1i2 64 2 sequences sequence NNS cord-269353-wgeuh1i2 64 3 of of IN cord-269353-wgeuh1i2 64 4 the the DT cord-269353-wgeuh1i2 64 5 hosts host NNS cord-269353-wgeuh1i2 64 6 were be VBD cord-269353-wgeuh1i2 64 7 obtained obtain VBN cord-269353-wgeuh1i2 64 8 from from IN cord-269353-wgeuh1i2 64 9 the the DT cord-269353-wgeuh1i2 64 10 Ensembl Ensembl NNP cord-269353-wgeuh1i2 64 11 database database NN cord-269353-wgeuh1i2 64 12 ( ( -LRB- cord-269353-wgeuh1i2 64 13 available available JJ cord-269353-wgeuh1i2 64 14 at at IN cord-269353-wgeuh1i2 64 15 : : : cord-269353-wgeuh1i2 64 16 http://www http://www ADD cord-269353-wgeuh1i2 64 17 . . . cord-269353-wgeuh1i2 65 1 ensembl.org ensembl.org LS cord-269353-wgeuh1i2 65 2 ) ) -RRB- cord-269353-wgeuh1i2 66 1 ( ( -LRB- cord-269353-wgeuh1i2 66 2 Yates Yates NNP cord-269353-wgeuh1i2 66 3 et et NNP cord-269353-wgeuh1i2 66 4 al al NNP cord-269353-wgeuh1i2 66 5 . . . cord-269353-wgeuh1i2 66 6 2016 2016 CD cord-269353-wgeuh1i2 66 7 ) ) -RRB- cord-269353-wgeuh1i2 66 8 . . . cord-269353-wgeuh1i2 67 1 Copy copy JJ cord-269353-wgeuh1i2 67 2 number number NN cord-269353-wgeuh1i2 67 3 of of IN cord-269353-wgeuh1i2 67 4 tRNAs trna NNS cord-269353-wgeuh1i2 67 5 for for IN cord-269353-wgeuh1i2 67 6 transmission transmission NN cord-269353-wgeuh1i2 67 7 vectors vector NNS cord-269353-wgeuh1i2 67 8 and and CC cord-269353-wgeuh1i2 67 9 hosts host NNS cord-269353-wgeuh1i2 67 10 were be VBD cord-269353-wgeuh1i2 67 11 obtained obtain VBN cord-269353-wgeuh1i2 67 12 from from IN cord-269353-wgeuh1i2 67 13 GtRNAdb GtRNAdb NNP cord-269353-wgeuh1i2 67 14 ( ( -LRB- cord-269353-wgeuh1i2 67 15 http://gtrnadb http://gtrnadb UH cord-269353-wgeuh1i2 67 16 . . . cord-269353-wgeuh1i2 68 1 ucsc.edu/ ucsc.edu/ NNP cord-269353-wgeuh1i2 68 2 ) ) -RRB- cord-269353-wgeuh1i2 68 3 . . . cord-269353-wgeuh1i2 69 1 Optimizing optimize VBG cord-269353-wgeuh1i2 69 2 codon codon NN cord-269353-wgeuh1i2 69 3 usage usage NN cord-269353-wgeuh1i2 69 4 of of IN cord-269353-wgeuh1i2 69 5 viruses virus NNS cord-269353-wgeuh1i2 69 6 according accord VBG cord-269353-wgeuh1i2 69 7 to to IN cord-269353-wgeuh1i2 69 8 that that DT cord-269353-wgeuh1i2 69 9 of of IN cord-269353-wgeuh1i2 69 10 highly highly RB cord-269353-wgeuh1i2 69 11 expressed express VBN cord-269353-wgeuh1i2 69 12 host host NN cord-269353-wgeuh1i2 69 13 genes gene NNS cord-269353-wgeuh1i2 69 14 has have VBZ cord-269353-wgeuh1i2 69 15 been be VBN cord-269353-wgeuh1i2 69 16 proved prove VBN cord-269353-wgeuh1i2 69 17 to to TO cord-269353-wgeuh1i2 69 18 increase increase VB cord-269353-wgeuh1i2 69 19 the the DT cord-269353-wgeuh1i2 69 20 production production NN cord-269353-wgeuh1i2 69 21 of of IN cord-269353-wgeuh1i2 69 22 viral viral JJ cord-269353-wgeuh1i2 69 23 proteins protein NNS cord-269353-wgeuh1i2 69 24 ( ( -LRB- cord-269353-wgeuh1i2 69 25 Chithambaram Chithambaram NNP cord-269353-wgeuh1i2 69 26 et et NNP cord-269353-wgeuh1i2 69 27 al al NNP cord-269353-wgeuh1i2 69 28 . . . cord-269353-wgeuh1i2 70 1 2014 2014 CD cord-269353-wgeuh1i2 70 2 ; ; : cord-269353-wgeuh1i2 70 3 Ngumbela Ngumbela NNP cord-269353-wgeuh1i2 70 4 et et NNP cord-269353-wgeuh1i2 70 5 al al NNP cord-269353-wgeuh1i2 70 6 . . NNP cord-269353-wgeuh1i2 70 7 2008 2008 CD cord-269353-wgeuh1i2 70 8 ) ) -RRB- cord-269353-wgeuh1i2 70 9 or or CC cord-269353-wgeuh1i2 70 10 transgenic transgenic JJ cord-269353-wgeuh1i2 70 11 genes gene NNS cord-269353-wgeuh1i2 71 1 ( ( -LRB- cord-269353-wgeuh1i2 71 2 Koresawa Koresawa NNP cord-269353-wgeuh1i2 71 3 et et NNP cord-269353-wgeuh1i2 71 4 al al NNP cord-269353-wgeuh1i2 71 5 . . . cord-269353-wgeuh1i2 71 6 2000 2000 CD cord-269353-wgeuh1i2 71 7 ) ) -RRB- cord-269353-wgeuh1i2 71 8 . . . cord-269353-wgeuh1i2 72 1 The the DT cord-269353-wgeuh1i2 72 2 degree degree NN cord-269353-wgeuh1i2 72 3 of of IN cord-269353-wgeuh1i2 72 4 similarity similarity NN cord-269353-wgeuh1i2 72 5 for for IN cord-269353-wgeuh1i2 72 6 overall overall JJ cord-269353-wgeuh1i2 72 7 codon codon NN cord-269353-wgeuh1i2 72 8 usage usage NN cord-269353-wgeuh1i2 72 9 between between IN cord-269353-wgeuh1i2 72 10 viruses virus NNS cord-269353-wgeuh1i2 72 11 and and CC cord-269353-wgeuh1i2 72 12 their -PRON- PRP$ cord-269353-wgeuh1i2 72 13 hosts host NNS cord-269353-wgeuh1i2 72 14 ' ' POS cord-269353-wgeuh1i2 72 15 tRNA trna NN cord-269353-wgeuh1i2 72 16 pools pool NNS cord-269353-wgeuh1i2 72 17 was be VBD cord-269353-wgeuh1i2 72 18 estimated estimate VBN cord-269353-wgeuh1i2 72 19 with with IN cord-269353-wgeuh1i2 72 20 a a DT cord-269353-wgeuh1i2 72 21 parameter parameter NN cord-269353-wgeuh1i2 72 22 based base VBN cord-269353-wgeuh1i2 72 23 on on IN cord-269353-wgeuh1i2 72 24 optimized optimize VBN cord-269353-wgeuh1i2 72 25 codon codon NN cord-269353-wgeuh1i2 72 26 usage usage NN cord-269353-wgeuh1i2 72 27 and and CC cord-269353-wgeuh1i2 72 28 the the DT cord-269353-wgeuh1i2 72 29 extent extent NN cord-269353-wgeuh1i2 72 30 of of IN cord-269353-wgeuh1i2 72 31 matching match VBG cord-269353-wgeuh1i2 72 32 between between IN cord-269353-wgeuh1i2 72 33 viral viral JJ cord-269353-wgeuh1i2 72 34 ORF ORF NNP cord-269353-wgeuh1i2 72 35 's 's POS cord-269353-wgeuh1i2 72 36 codon codon NN cord-269353-wgeuh1i2 72 37 usage usage NN cord-269353-wgeuh1i2 72 38 bias bias NN cord-269353-wgeuh1i2 72 39 and and CC cord-269353-wgeuh1i2 72 40 their -PRON- PRP$ cord-269353-wgeuh1i2 72 41 hosts host NNS cord-269353-wgeuh1i2 72 42 ' ' POS cord-269353-wgeuh1i2 72 43 tRNA trna NN cord-269353-wgeuh1i2 72 44 pools pool NNS cord-269353-wgeuh1i2 72 45 . . . cord-269353-wgeuh1i2 73 1 ORFs ORFs NNP cord-269353-wgeuh1i2 73 2 were be VBD cord-269353-wgeuh1i2 73 3 optimized optimize VBN cord-269353-wgeuh1i2 73 4 on on IN cord-269353-wgeuh1i2 73 5 the the DT cord-269353-wgeuh1i2 73 6 basis basis NN cord-269353-wgeuh1i2 73 7 of of IN cord-269353-wgeuh1i2 73 8 tRNA tRNA NNP cord-269353-wgeuh1i2 73 9 copy copy NN cord-269353-wgeuh1i2 73 10 number number NN cord-269353-wgeuh1i2 73 11 characteristics characteristic NNS cord-269353-wgeuh1i2 73 12 of of IN cord-269353-wgeuh1i2 73 13 their -PRON- PRP$ cord-269353-wgeuh1i2 73 14 hosts host NNS cord-269353-wgeuh1i2 73 15 ' ' POS cord-269353-wgeuh1i2 73 16 expression expression NN cord-269353-wgeuh1i2 73 17 system system NN cord-269353-wgeuh1i2 73 18 . . . cord-269353-wgeuh1i2 74 1 Online online JJ cord-269353-wgeuh1i2 74 2 optimization optimization NN cord-269353-wgeuh1i2 74 3 software software NN cord-269353-wgeuh1i2 74 4 ( ( -LRB- cord-269353-wgeuh1i2 74 5 http://genomes.urv.es/OPTIMIZER/ http://genomes.urv.es/optimizer/ NN cord-269353-wgeuh1i2 74 6 ) ) -RRB- cord-269353-wgeuh1i2 75 1 ( ( -LRB- cord-269353-wgeuh1i2 75 2 Puigbo Puigbo NNP cord-269353-wgeuh1i2 75 3 et et NNP cord-269353-wgeuh1i2 75 4 al al NNP cord-269353-wgeuh1i2 75 5 . . NNP cord-269353-wgeuh1i2 75 6 2007 2007 CD cord-269353-wgeuh1i2 75 7 ) ) -RRB- cord-269353-wgeuh1i2 75 8 was be VBD cord-269353-wgeuh1i2 75 9 utilized utilize VBN cord-269353-wgeuh1i2 75 10 . . . cord-269353-wgeuh1i2 76 1 The the DT cord-269353-wgeuh1i2 76 2 matching matching NN cord-269353-wgeuh1i2 76 3 degree degree NN cord-269353-wgeuh1i2 76 4 ( ( -LRB- cord-269353-wgeuh1i2 76 5 MD MD NNP cord-269353-wgeuh1i2 76 6 ) ) -RRB- cord-269353-wgeuh1i2 76 7 was be VBD cord-269353-wgeuh1i2 76 8 calculated calculate VBN cord-269353-wgeuh1i2 76 9 as as IN cord-269353-wgeuh1i2 76 10 follows follow VBZ cord-269353-wgeuh1i2 76 11 : : : cord-269353-wgeuh1i2 76 12 where where WRB cord-269353-wgeuh1i2 76 13 M M NNP cord-269353-wgeuh1i2 76 14 was be VBD cord-269353-wgeuh1i2 76 15 defined define VBN cord-269353-wgeuh1i2 76 16 as as IN cord-269353-wgeuh1i2 76 17 the the DT cord-269353-wgeuh1i2 76 18 number number NN cord-269353-wgeuh1i2 76 19 of of IN cord-269353-wgeuh1i2 76 20 the the DT cord-269353-wgeuh1i2 76 21 different different JJ cord-269353-wgeuh1i2 76 22 bases basis NNS cord-269353-wgeuh1i2 76 23 before before IN cord-269353-wgeuh1i2 76 24 and and CC cord-269353-wgeuh1i2 76 25 after after IN cord-269353-wgeuh1i2 76 26 optimized optimize VBN cord-269353-wgeuh1i2 76 27 sequence sequence NN cord-269353-wgeuh1i2 76 28 , , , cord-269353-wgeuh1i2 76 29 and and CC cord-269353-wgeuh1i2 76 30 N N NNP cord-269353-wgeuh1i2 76 31 was be VBD cord-269353-wgeuh1i2 76 32 the the DT cord-269353-wgeuh1i2 76 33 total total JJ cord-269353-wgeuh1i2 76 34 length length NN cord-269353-wgeuh1i2 76 35 of of IN cord-269353-wgeuh1i2 76 36 open open JJ cord-269353-wgeuh1i2 76 37 reading reading NN cord-269353-wgeuh1i2 76 38 frame frame NN cord-269353-wgeuh1i2 76 39 . . . cord-269353-wgeuh1i2 77 1 This this DT cord-269353-wgeuh1i2 77 2 value value NN cord-269353-wgeuh1i2 77 3 could could MD cord-269353-wgeuh1i2 77 4 have have VB cord-269353-wgeuh1i2 77 5 ranged range VBN cord-269353-wgeuh1i2 77 6 from from IN cord-269353-wgeuh1i2 77 7 zero zero CD cord-269353-wgeuh1i2 77 8 to to IN cord-269353-wgeuh1i2 77 9 1 1 CD cord-269353-wgeuh1i2 77 10 . . . cord-269353-wgeuh1i2 78 1 To to TO cord-269353-wgeuh1i2 78 2 better well RBR cord-269353-wgeuh1i2 78 3 quantify quantify VB cord-269353-wgeuh1i2 78 4 the the DT cord-269353-wgeuh1i2 78 5 effect effect NN cord-269353-wgeuh1i2 78 6 of of IN cord-269353-wgeuh1i2 78 7 the the DT cord-269353-wgeuh1i2 78 8 overall overall JJ cord-269353-wgeuh1i2 78 9 codon codon NN cord-269353-wgeuh1i2 78 10 usage usage NN cord-269353-wgeuh1i2 78 11 of of IN cord-269353-wgeuh1i2 78 12 the the DT cord-269353-wgeuh1i2 78 13 host host NN cord-269353-wgeuh1i2 78 14 on on IN cord-269353-wgeuh1i2 78 15 the the DT cord-269353-wgeuh1i2 78 16 formation formation NN cord-269353-wgeuh1i2 78 17 of of IN cord-269353-wgeuh1i2 78 18 the the DT cord-269353-wgeuh1i2 78 19 overall overall JJ cord-269353-wgeuh1i2 78 20 codon codon NN cord-269353-wgeuh1i2 78 21 usage usage NN cord-269353-wgeuh1i2 78 22 of of IN cord-269353-wgeuh1i2 78 23 the the DT cord-269353-wgeuh1i2 78 24 virus virus NN cord-269353-wgeuh1i2 78 25 , , , cord-269353-wgeuh1i2 78 26 the the DT cord-269353-wgeuh1i2 78 27 similarity similarity NN cord-269353-wgeuh1i2 78 28 index index NN cord-269353-wgeuh1i2 78 29 D(A d(a NN cord-269353-wgeuh1i2 78 30 , , , cord-269353-wgeuh1i2 78 31 B B NNP cord-269353-wgeuh1i2 78 32 ) ) -RRB- cord-269353-wgeuh1i2 78 33 reported report VBN cord-269353-wgeuh1i2 78 34 by by IN cord-269353-wgeuh1i2 78 35 the the DT cord-269353-wgeuh1i2 78 36 previous previous JJ cord-269353-wgeuh1i2 78 37 study study NN cord-269353-wgeuh1i2 78 38 was be VBD cord-269353-wgeuh1i2 78 39 introduced introduce VBN cord-269353-wgeuh1i2 78 40 into into IN cord-269353-wgeuh1i2 78 41 our -PRON- PRP$ cord-269353-wgeuh1i2 78 42 work work NN cord-269353-wgeuh1i2 79 1 ( ( -LRB- cord-269353-wgeuh1i2 79 2 Zhou Zhou NNP cord-269353-wgeuh1i2 79 3 et et NNP cord-269353-wgeuh1i2 79 4 al al NNP cord-269353-wgeuh1i2 79 5 . . NNP cord-269353-wgeuh1i2 79 6 2013 2013 CD cord-269353-wgeuh1i2 79 7 ) ) -RRB- cord-269353-wgeuh1i2 79 8 . . . cord-269353-wgeuh1i2 80 1 The the DT cord-269353-wgeuh1i2 80 2 D(A d(a NN cord-269353-wgeuh1i2 80 3 , , , cord-269353-wgeuh1i2 80 4 B B NNP cord-269353-wgeuh1i2 80 5 ) ) -RRB- cord-269353-wgeuh1i2 80 6 represented represent VBD cord-269353-wgeuh1i2 80 7 the the DT cord-269353-wgeuh1i2 80 8 potential potential JJ cord-269353-wgeuh1i2 80 9 effect effect NN cord-269353-wgeuh1i2 80 10 of of IN cord-269353-wgeuh1i2 80 11 the the DT cord-269353-wgeuh1i2 80 12 overall overall JJ cord-269353-wgeuh1i2 80 13 codon codon NN cord-269353-wgeuh1i2 80 14 usage usage NN cord-269353-wgeuh1i2 80 15 of of IN cord-269353-wgeuh1i2 80 16 the the DT cord-269353-wgeuh1i2 80 17 host host NN cord-269353-wgeuh1i2 80 18 on on IN cord-269353-wgeuh1i2 80 19 that that DT cord-269353-wgeuh1i2 80 20 of of IN cord-269353-wgeuh1i2 80 21 virus virus NN cord-269353-wgeuh1i2 80 22 . . . cord-269353-wgeuh1i2 81 1 This this DT cord-269353-wgeuh1i2 81 2 value value NN cord-269353-wgeuh1i2 81 3 potentially potentially RB cord-269353-wgeuh1i2 81 4 ranged range VBD cord-269353-wgeuh1i2 81 5 from from IN cord-269353-wgeuh1i2 81 6 zero zero CD cord-269353-wgeuh1i2 81 7 to to IN cord-269353-wgeuh1i2 81 8 1.0 1.0 CD cord-269353-wgeuh1i2 81 9 . . . cord-269353-wgeuh1i2 82 1 3.1 3.1 LS cord-269353-wgeuh1i2 82 2 . . . cord-269353-wgeuh1i2 83 1 The the DT cord-269353-wgeuh1i2 83 2 matching matching NN cord-269353-wgeuh1i2 83 3 degree degree NN cord-269353-wgeuh1i2 83 4 of of IN cord-269353-wgeuh1i2 83 5 + + SYM cord-269353-wgeuh1i2 83 6 ssRNA ssrna NN cord-269353-wgeuh1i2 83 7 viruses virus NNS cord-269353-wgeuh1i2 83 8 to to IN cord-269353-wgeuh1i2 83 9 their -PRON- PRP$ cord-269353-wgeuh1i2 83 10 hosts host NNS cord-269353-wgeuh1i2 83 11 ' ' POS cord-269353-wgeuh1i2 83 12 tRNA tRNA NNP cord-269353-wgeuh1i2 83 13 pools pool NNS cord-269353-wgeuh1i2 83 14 MD MD NNP cord-269353-wgeuh1i2 83 15 values value NNS cord-269353-wgeuh1i2 83 16 were be VBD cord-269353-wgeuh1i2 83 17 calculated calculate VBN cord-269353-wgeuh1i2 83 18 for for IN cord-269353-wgeuh1i2 83 19 viral viral JJ cord-269353-wgeuh1i2 83 20 ORFs ORFs NNP cord-269353-wgeuh1i2 83 21 . . . cord-269353-wgeuh1i2 84 1 Unfortunately unfortunately RB cord-269353-wgeuh1i2 84 2 , , , cord-269353-wgeuh1i2 84 3 some some DT cord-269353-wgeuh1i2 84 4 viruses virus NNS cord-269353-wgeuh1i2 84 5 lacked lack VBD cord-269353-wgeuh1i2 84 6 data datum NNS cord-269353-wgeuh1i2 84 7 of of IN cord-269353-wgeuh1i2 84 8 tRNA tRNA NNP cord-269353-wgeuh1i2 84 9 copy copy NN cord-269353-wgeuh1i2 84 10 numbers number NNS cord-269353-wgeuh1i2 84 11 , , , cord-269353-wgeuh1i2 84 12 and and CC cord-269353-wgeuh1i2 84 13 coding code VBG cord-269353-wgeuh1i2 84 14 sequence sequence NN cord-269353-wgeuh1i2 84 15 of of IN cord-269353-wgeuh1i2 84 16 their -PRON- PRP$ cord-269353-wgeuh1i2 84 17 hosts host NNS cord-269353-wgeuh1i2 84 18 . . . cord-269353-wgeuh1i2 85 1 Therefore therefore RB cord-269353-wgeuh1i2 85 2 , , , cord-269353-wgeuh1i2 85 3 only only RB cord-269353-wgeuh1i2 85 4 255 255 CD cord-269353-wgeuh1i2 85 5 viruses virus NNS cord-269353-wgeuh1i2 85 6 ( ( -LRB- cord-269353-wgeuh1i2 85 7 + + CC cord-269353-wgeuh1i2 85 8 ssRNA ssrna NN cord-269353-wgeuh1i2 85 9 ) ) -RRB- cord-269353-wgeuh1i2 85 10 were be VBD cord-269353-wgeuh1i2 85 11 used use VBN cord-269353-wgeuh1i2 85 12 in in IN cord-269353-wgeuh1i2 85 13 this this DT cord-269353-wgeuh1i2 85 14 analysis analysis NN cord-269353-wgeuh1i2 85 15 . . . cord-269353-wgeuh1i2 86 1 The the DT cord-269353-wgeuh1i2 86 2 101 101 CD cord-269353-wgeuh1i2 86 3 strains strain NNS cord-269353-wgeuh1i2 86 4 of of IN cord-269353-wgeuh1i2 86 5 arboviruses arbovirus NNS cord-269353-wgeuh1i2 86 6 that that WDT cord-269353-wgeuh1i2 86 7 belonged belong VBD cord-269353-wgeuh1i2 86 8 to to IN cord-269353-wgeuh1i2 86 9 BSTVs bstv NNS cord-269353-wgeuh1i2 86 10 were be VBD cord-269353-wgeuh1i2 86 11 optimized optimize VBN cord-269353-wgeuh1i2 86 12 according accord VBG cord-269353-wgeuh1i2 86 13 to to IN cord-269353-wgeuh1i2 86 14 their -PRON- PRP$ cord-269353-wgeuh1i2 86 15 hosts host NNS cord-269353-wgeuh1i2 86 16 ' ' POS cord-269353-wgeuh1i2 86 17 tRNA tRNA NNP cord-269353-wgeuh1i2 86 18 pool pool NN cord-269353-wgeuh1i2 86 19 expression expression NN cord-269353-wgeuh1i2 86 20 systems system NNS cord-269353-wgeuh1i2 86 21 ( ( -LRB- cord-269353-wgeuh1i2 86 22 host host NN cord-269353-wgeuh1i2 86 23 : : : cord-269353-wgeuh1i2 86 24 arthropods arthropod NNS cord-269353-wgeuh1i2 86 25 , , , cord-269353-wgeuh1i2 86 26 mammals mammal NNS cord-269353-wgeuh1i2 86 27 , , , cord-269353-wgeuh1i2 86 28 Gallus Gallus NNP cord-269353-wgeuh1i2 86 29 gallus gallus NN cord-269353-wgeuh1i2 86 30 ) ) -RRB- cord-269353-wgeuh1i2 86 31 . . . cord-269353-wgeuh1i2 87 1 MD MD NNP cord-269353-wgeuh1i2 87 2 values value NNS cord-269353-wgeuh1i2 87 3 ( ( -LRB- cord-269353-wgeuh1i2 87 4 mean mean VB cord-269353-wgeuh1i2 87 5 ± ± NNP cord-269353-wgeuh1i2 87 6 SD SD NNP cord-269353-wgeuh1i2 87 7 ) ) -RRB- cord-269353-wgeuh1i2 87 8 were be VBD cord-269353-wgeuh1i2 87 9 0.7388 0.7388 CD cord-269353-wgeuh1i2 87 10 ± ± CD cord-269353-wgeuh1i2 87 11 0.0121 0.0121 CD cord-269353-wgeuh1i2 87 12 , , , cord-269353-wgeuh1i2 87 13 0.7383 0.7383 CD cord-269353-wgeuh1i2 87 14 ± ± CD cord-269353-wgeuh1i2 87 15 0.0083 0.0083 CD cord-269353-wgeuh1i2 87 16 , , , cord-269353-wgeuh1i2 87 17 and and CC cord-269353-wgeuh1i2 87 18 0.7427 0.7427 CD cord-269353-wgeuh1i2 87 19 ± ± CD cord-269353-wgeuh1i2 87 20 0.0045 0.0045 CD cord-269353-wgeuh1i2 87 21 in in IN cord-269353-wgeuh1i2 87 22 the the DT cord-269353-wgeuh1i2 87 23 three three CD cord-269353-wgeuh1i2 87 24 hosts host NNS cord-269353-wgeuh1i2 87 25 , , , cord-269353-wgeuh1i2 87 26 respectively respectively RB cord-269353-wgeuh1i2 87 27 ( ( -LRB- cord-269353-wgeuh1i2 87 28 Supplementary supplementary JJ cord-269353-wgeuh1i2 87 29 Table Table NNP cord-269353-wgeuh1i2 87 30 2 2 CD cord-269353-wgeuh1i2 87 31 ) ) -RRB- cord-269353-wgeuh1i2 87 32 . . . cord-269353-wgeuh1i2 88 1 The the DT cord-269353-wgeuh1i2 88 2 MD MD NNP cord-269353-wgeuh1i2 88 3 values value NNS cord-269353-wgeuh1i2 88 4 of of IN cord-269353-wgeuh1i2 88 5 154 154 CD cord-269353-wgeuh1i2 88 6 NSTVs nstv NNS cord-269353-wgeuh1i2 88 7 strains strain NNS cord-269353-wgeuh1i2 88 8 had have VBD cord-269353-wgeuh1i2 88 9 a a DT cord-269353-wgeuh1i2 88 10 mean mean NN cord-269353-wgeuh1i2 88 11 of of IN cord-269353-wgeuh1i2 88 12 0.7617 0.7617 CD cord-269353-wgeuh1i2 88 13 ± ± CD cord-269353-wgeuh1i2 88 14 0.0168 0.0168 CD cord-269353-wgeuh1i2 88 15 ( ( -LRB- cord-269353-wgeuh1i2 88 16 Supplementary supplementary JJ cord-269353-wgeuh1i2 88 17 _SP cord-269353-wgeuh1i2 88 18 Table Table NNP cord-269353-wgeuh1i2 88 19 3 3 CD cord-269353-wgeuh1i2 88 20 ) ) -RRB- cord-269353-wgeuh1i2 88 21 . . . cord-269353-wgeuh1i2 89 1 Wilcoxon Wilcoxon NNP cord-269353-wgeuh1i2 89 2 & & CC cord-269353-wgeuh1i2 89 3 Mann Mann NNP cord-269353-wgeuh1i2 89 4 - - HYPH cord-269353-wgeuh1i2 89 5 Whitney Whitney NNP cord-269353-wgeuh1i2 89 6 U U NNP cord-269353-wgeuh1i2 89 7 test test NN cord-269353-wgeuh1i2 89 8 obtained obtain VBD cord-269353-wgeuh1i2 89 9 statistically statistically RB cord-269353-wgeuh1i2 89 10 significant significant JJ cord-269353-wgeuh1i2 89 11 higher high JJR cord-269353-wgeuh1i2 89 12 MD MD NNP cord-269353-wgeuh1i2 89 13 values value NNS cord-269353-wgeuh1i2 89 14 in in IN cord-269353-wgeuh1i2 89 15 NSTVs nstv NNS cord-269353-wgeuh1i2 89 16 than than IN cord-269353-wgeuh1i2 89 17 BSTVs bstv NNS cord-269353-wgeuh1i2 89 18 ( ( -LRB- cord-269353-wgeuh1i2 89 19 Z z NN cord-269353-wgeuh1i2 89 20 = = SYM cord-269353-wgeuh1i2 89 21 −9.99 −9.99 NNP cord-269353-wgeuh1i2 89 22 , , , cord-269353-wgeuh1i2 89 23 p p NN cord-269353-wgeuh1i2 89 24 < < XX cord-269353-wgeuh1i2 89 25 0.001 0.001 XX cord-269353-wgeuh1i2 89 26 ; ; : cord-269353-wgeuh1i2 89 27 Z z NN cord-269353-wgeuh1i2 89 28 = = SYM cord-269353-wgeuh1i2 89 29 −10.25 −10.25 NNS cord-269353-wgeuh1i2 89 30 , , , cord-269353-wgeuh1i2 89 31 p p NN cord-269353-wgeuh1i2 89 32 < < XX cord-269353-wgeuh1i2 89 33 0.001 0.001 XX cord-269353-wgeuh1i2 89 34 ; ; : cord-269353-wgeuh1i2 89 35 Z z NN cord-269353-wgeuh1i2 89 36 = = NFP cord-269353-wgeuh1i2 90 1 −5.59 −5.59 NNP cord-269353-wgeuh1i2 90 2 , , , cord-269353-wgeuh1i2 90 3 p p NN cord-269353-wgeuh1i2 90 4 < < XX cord-269353-wgeuh1i2 90 5 0.001 0.001 CD cord-269353-wgeuh1i2 90 6 , , , cord-269353-wgeuh1i2 90 7 respectively respectively RB cord-269353-wgeuh1i2 90 8 . . . cord-269353-wgeuh1i2 91 1 Fig Fig NNP cord-269353-wgeuh1i2 91 2 . . . cord-269353-wgeuh1i2 91 3 1a 1a CD cord-269353-wgeuh1i2 91 4 ) ) -RRB- cord-269353-wgeuh1i2 91 5 . . . cord-269353-wgeuh1i2 92 1 Among among IN cord-269353-wgeuh1i2 92 2 the the DT cord-269353-wgeuh1i2 92 3 different different JJ cord-269353-wgeuh1i2 92 4 genera genus NNS cord-269353-wgeuh1i2 92 5 of of IN cord-269353-wgeuh1i2 92 6 arbovirus arbovirus NN cord-269353-wgeuh1i2 92 7 ( ( -LRB- cord-269353-wgeuh1i2 92 8 Fig Fig NNP cord-269353-wgeuh1i2 92 9 . . . cord-269353-wgeuh1i2 92 10 1b 1b CD cord-269353-wgeuh1i2 92 11 ) ) -RRB- cord-269353-wgeuh1i2 92 12 , , , cord-269353-wgeuh1i2 92 13 the the DT cord-269353-wgeuh1i2 92 14 extent extent NN cord-269353-wgeuh1i2 92 15 of of IN cord-269353-wgeuh1i2 92 16 matching match VBG cord-269353-wgeuh1i2 92 17 for for IN cord-269353-wgeuh1i2 92 18 Flavivirus Flavivirus NNP cord-269353-wgeuh1i2 92 19 to to IN cord-269353-wgeuh1i2 92 20 their -PRON- PRP$ cord-269353-wgeuh1i2 92 21 hosts host NNS cord-269353-wgeuh1i2 92 22 ' ' POS cord-269353-wgeuh1i2 92 23 tRNA trna NN cord-269353-wgeuh1i2 92 24 pools pool NNS cord-269353-wgeuh1i2 92 25 was be VBD cord-269353-wgeuh1i2 92 26 higher high JJR cord-269353-wgeuh1i2 92 27 than than IN cord-269353-wgeuh1i2 92 28 that that DT cord-269353-wgeuh1i2 92 29 of of IN cord-269353-wgeuh1i2 92 30 Alphavirus Alphavirus NNP cord-269353-wgeuh1i2 92 31 . . . cord-269353-wgeuh1i2 93 1 In in IN cord-269353-wgeuh1i2 93 2 addition addition NN cord-269353-wgeuh1i2 93 3 , , , cord-269353-wgeuh1i2 93 4 among among IN cord-269353-wgeuh1i2 93 5 the the DT cord-269353-wgeuh1i2 93 6 18 18 CD cord-269353-wgeuh1i2 93 7 genera genus NNS cord-269353-wgeuh1i2 93 8 of of IN cord-269353-wgeuh1i2 93 9 NSTVs nstv NNS cord-269353-wgeuh1i2 93 10 , , , cord-269353-wgeuh1i2 93 11 the the DT cord-269353-wgeuh1i2 93 12 MD MD NNP cord-269353-wgeuh1i2 93 13 values value NNS cord-269353-wgeuh1i2 93 14 of of IN cord-269353-wgeuh1i2 93 15 Togaviridae Togaviridae NNP cord-269353-wgeuh1i2 93 16 ( ( -LRB- cord-269353-wgeuh1i2 93 17 rubivirus rubivirus NNP cord-269353-wgeuh1i2 93 18 ) ) -RRB- cord-269353-wgeuh1i2 93 19 were be VBD cord-269353-wgeuh1i2 93 20 the the DT cord-269353-wgeuh1i2 93 21 highest high JJS cord-269353-wgeuh1i2 93 22 , , , cord-269353-wgeuh1i2 93 23 followed follow VBN cord-269353-wgeuh1i2 93 24 by by IN cord-269353-wgeuh1i2 93 25 _SP cord-269353-wgeuh1i2 93 26 Similarity Similarity NNP cord-269353-wgeuh1i2 93 27 index index NN cord-269353-wgeuh1i2 93 28 values value NNS cord-269353-wgeuh1i2 93 29 D(A d(a VBP cord-269353-wgeuh1i2 93 30 , , , cord-269353-wgeuh1i2 93 31 B b NN cord-269353-wgeuh1i2 93 32 ) ) -RRB- cord-269353-wgeuh1i2 93 33 were be VBD cord-269353-wgeuh1i2 93 34 obtained obtain VBN cord-269353-wgeuh1i2 93 35 for for IN cord-269353-wgeuh1i2 93 36 each each DT cord-269353-wgeuh1i2 93 37 strain strain NN cord-269353-wgeuh1i2 93 38 in in IN cord-269353-wgeuh1i2 93 39 relation relation NN cord-269353-wgeuh1i2 93 40 to to IN cord-269353-wgeuh1i2 93 41 its -PRON- PRP$ cord-269353-wgeuh1i2 93 42 host(s host(s NNP cord-269353-wgeuh1i2 93 43 ) ) -RRB- cord-269353-wgeuh1i2 93 44 ( ( -LRB- cord-269353-wgeuh1i2 93 45 Supplementary Supplementary NNP cord-269353-wgeuh1i2 93 46 Tables Tables NNPS cord-269353-wgeuh1i2 93 47 2 2 CD cord-269353-wgeuh1i2 93 48 and and CC cord-269353-wgeuh1i2 93 49 3 3 CD cord-269353-wgeuh1i2 93 50 ) ) -RRB- cord-269353-wgeuh1i2 93 51 . . . cord-269353-wgeuh1i2 94 1 As as IN cord-269353-wgeuh1i2 94 2 shown show VBN cord-269353-wgeuh1i2 94 3 in in IN cord-269353-wgeuh1i2 94 4 Fig Fig NNP cord-269353-wgeuh1i2 94 5 . . . cord-269353-wgeuh1i2 95 1 2a 2a LS cord-269353-wgeuh1i2 95 2 , , , cord-269353-wgeuh1i2 95 3 the the DT cord-269353-wgeuh1i2 95 4 indices index NNS cord-269353-wgeuh1i2 95 5 of of IN cord-269353-wgeuh1i2 95 6 the the DT cord-269353-wgeuh1i2 95 7 fourth fourth JJ cord-269353-wgeuh1i2 95 8 group group NN cord-269353-wgeuh1i2 95 9 ( ( -LRB- cord-269353-wgeuh1i2 95 10 NSTVs nstv NNS cord-269353-wgeuh1i2 95 11 vs vs IN cord-269353-wgeuh1i2 95 12 hosts host NNS cord-269353-wgeuh1i2 95 13 ) ) -RRB- cord-269353-wgeuh1i2 95 14 were be VBD cord-269353-wgeuh1i2 95 15 higher high JJR cord-269353-wgeuh1i2 95 16 than than IN cord-269353-wgeuh1i2 95 17 those those DT cord-269353-wgeuh1i2 95 18 of of IN cord-269353-wgeuh1i2 95 19 the the DT cord-269353-wgeuh1i2 95 20 groups group NNS cord-269353-wgeuh1i2 95 21 1 1 CD cord-269353-wgeuh1i2 95 22 , , , cord-269353-wgeuh1i2 95 23 2 2 CD cord-269353-wgeuh1i2 95 24 , , , cord-269353-wgeuh1i2 95 25 and and CC cord-269353-wgeuh1i2 95 26 3 3 LS cord-269353-wgeuh1i2 95 27 ( ( -LRB- cord-269353-wgeuh1i2 95 28 BSTVs bstv NNS cord-269353-wgeuh1i2 95 29 vs vs IN cord-269353-wgeuh1i2 95 30 arthropods arthropod NNS cord-269353-wgeuh1i2 95 31 , , , cord-269353-wgeuh1i2 95 32 BSTVs bstv NNS cord-269353-wgeuh1i2 95 33 vs vs IN cord-269353-wgeuh1i2 95 34 mammals mammal NNS cord-269353-wgeuh1i2 95 35 , , , cord-269353-wgeuh1i2 95 36 BSTVs bstv NNS cord-269353-wgeuh1i2 95 37 vs vs IN cord-269353-wgeuh1i2 95 38 Gallus Gallus NNP cord-269353-wgeuh1i2 95 39 gallus gallus NN cord-269353-wgeuh1i2 95 40 ) ) -RRB- cord-269353-wgeuh1i2 95 41 . . . cord-269353-wgeuh1i2 96 1 To to TO cord-269353-wgeuh1i2 96 2 quantify quantify VB cord-269353-wgeuh1i2 96 3 the the DT cord-269353-wgeuh1i2 96 4 degree degree NN cord-269353-wgeuh1i2 96 5 of of IN cord-269353-wgeuh1i2 96 6 similarity similarity NN cord-269353-wgeuh1i2 96 7 of of IN cord-269353-wgeuh1i2 96 8 the the DT cord-269353-wgeuh1i2 96 9 overall overall JJ cord-269353-wgeuh1i2 96 10 codon codon NN cord-269353-wgeuh1i2 96 11 usage usage NN cord-269353-wgeuh1i2 96 12 pattern pattern NN cord-269353-wgeuh1i2 96 13 between between IN cord-269353-wgeuh1i2 96 14 20 20 CD cord-269353-wgeuh1i2 96 15 different different JJ cord-269353-wgeuh1i2 96 16 virus virus NN cord-269353-wgeuh1i2 96 17 genera genus NNS cord-269353-wgeuh1i2 96 18 and and CC cord-269353-wgeuh1i2 96 19 their -PRON- PRP$ cord-269353-wgeuh1i2 96 20 hosts host NNS cord-269353-wgeuh1i2 96 21 , , , cord-269353-wgeuh1i2 96 22 the the DT cord-269353-wgeuh1i2 96 23 similarity similarity NN cord-269353-wgeuh1i2 96 24 index index NN cord-269353-wgeuh1i2 96 25 D(A d(a NN cord-269353-wgeuh1i2 96 26 , , , cord-269353-wgeuh1i2 96 27 B B NNP cord-269353-wgeuh1i2 96 28 ) ) -RRB- cord-269353-wgeuh1i2 96 29 was be VBD cord-269353-wgeuh1i2 96 30 calculated calculate VBN cord-269353-wgeuh1i2 96 31 to to IN cord-269353-wgeuh1i2 96 32 all all DT cord-269353-wgeuh1i2 96 33 strains strain NNS cord-269353-wgeuh1i2 96 34 ( ( -LRB- cord-269353-wgeuh1i2 96 35 Fig Fig NNP cord-269353-wgeuh1i2 96 36 . . . cord-269353-wgeuh1i2 96 37 2b 2b LS cord-269353-wgeuh1i2 96 38 ) ) -RRB- cord-269353-wgeuh1i2 97 1 ( ( -LRB- cord-269353-wgeuh1i2 97 2 Fig Fig NNP cord-269353-wgeuh1i2 97 3 . . . cord-269353-wgeuh1i2 97 4 3 3 CD cord-269353-wgeuh1i2 97 5 ) ) -RRB- cord-269353-wgeuh1i2 97 6 . . . cord-269353-wgeuh1i2 98 1 The the DT cord-269353-wgeuh1i2 98 2 degeneracy degeneracy NN cord-269353-wgeuh1i2 98 3 of of IN cord-269353-wgeuh1i2 98 4 the the DT cord-269353-wgeuh1i2 98 5 genetic genetic JJ cord-269353-wgeuh1i2 98 6 code code NN cord-269353-wgeuh1i2 98 7 implies imply VBZ cord-269353-wgeuh1i2 98 8 that that IN cord-269353-wgeuh1i2 98 9 several several JJ cord-269353-wgeuh1i2 98 10 triplets triplet NNS cord-269353-wgeuh1i2 98 11 can can MD cord-269353-wgeuh1i2 98 12 code code VB cord-269353-wgeuh1i2 98 13 for for IN cord-269353-wgeuh1i2 98 14 the the DT cord-269353-wgeuh1i2 98 15 same same JJ cord-269353-wgeuh1i2 98 16 amino amino NN cord-269353-wgeuh1i2 98 17 acid acid NN cord-269353-wgeuh1i2 98 18 . . . cord-269353-wgeuh1i2 99 1 The the DT cord-269353-wgeuh1i2 99 2 use use NN cord-269353-wgeuh1i2 99 3 of of IN cord-269353-wgeuh1i2 99 4 synonymous synonymous JJ cord-269353-wgeuh1i2 99 5 codons codon NNS cord-269353-wgeuh1i2 99 6 in in IN cord-269353-wgeuh1i2 99 7 gene gene NN cord-269353-wgeuh1i2 99 8 coding coding NN cord-269353-wgeuh1i2 99 9 regions region NNS cord-269353-wgeuh1i2 99 10 dos do NNS cord-269353-wgeuh1i2 99 11 not not RB cord-269353-wgeuh1i2 99 12 occur occur VBP cord-269353-wgeuh1i2 99 13 randomly randomly RB cord-269353-wgeuh1i2 99 14 , , , cord-269353-wgeuh1i2 99 15 and and CC cord-269353-wgeuh1i2 99 16 codon codon NN cord-269353-wgeuh1i2 99 17 usage usage NN cord-269353-wgeuh1i2 99 18 bias bias NN cord-269353-wgeuh1i2 99 19 is be VBZ cord-269353-wgeuh1i2 99 20 very very RB cord-269353-wgeuh1i2 99 21 common common JJ cord-269353-wgeuh1i2 99 22 in in IN cord-269353-wgeuh1i2 99 23 viruses virus NNS cord-269353-wgeuh1i2 100 1 ( ( -LRB- cord-269353-wgeuh1i2 100 2 Butt Butt NNP cord-269353-wgeuh1i2 100 3 et et FW cord-269353-wgeuh1i2 100 4 al al NNP cord-269353-wgeuh1i2 100 5 . . . cord-269353-wgeuh1i2 101 1 2014 2014 CD cord-269353-wgeuh1i2 101 2 ; ; : cord-269353-wgeuh1i2 101 3 Cristina Cristina NNP cord-269353-wgeuh1i2 101 4 et et NNP cord-269353-wgeuh1i2 101 5 al al NNP cord-269353-wgeuh1i2 101 6 . . . cord-269353-wgeuh1i2 101 7 2016 2016 CD cord-269353-wgeuh1i2 102 1 ; ; : cord-269353-wgeuh1i2 102 2 He -PRON- PRP cord-269353-wgeuh1i2 102 3 et et FW cord-269353-wgeuh1i2 102 4 al al NNP cord-269353-wgeuh1i2 102 5 . . . cord-269353-wgeuh1i2 102 6 2017 2017 CD cord-269353-wgeuh1i2 103 1 ; ; : cord-269353-wgeuh1i2 103 2 Moratorio Moratorio NNP cord-269353-wgeuh1i2 103 3 et et NNP cord-269353-wgeuh1i2 103 4 al al NNP cord-269353-wgeuh1i2 103 5 . . . cord-269353-wgeuh1i2 104 1 2013 2013 CD cord-269353-wgeuh1i2 104 2 ; ; : cord-269353-wgeuh1i2 104 3 Singh Singh NNP cord-269353-wgeuh1i2 104 4 et et NNP cord-269353-wgeuh1i2 104 5 al al NNP cord-269353-wgeuh1i2 104 6 . . . cord-269353-wgeuh1i2 104 7 2016 2016 CD cord-269353-wgeuh1i2 104 8 ) ) -RRB- cord-269353-wgeuh1i2 104 9 . . . cord-269353-wgeuh1i2 105 1 Codon codon NN cord-269353-wgeuh1i2 105 2 usage usage NN cord-269353-wgeuh1i2 105 3 is be VBZ cord-269353-wgeuh1i2 105 4 among among IN cord-269353-wgeuh1i2 105 5 the the DT cord-269353-wgeuh1i2 105 6 determinant determinant JJ cord-269353-wgeuh1i2 105 7 factors factor NNS cord-269353-wgeuh1i2 105 8 that that WDT cord-269353-wgeuh1i2 105 9 influence influence VBP cord-269353-wgeuh1i2 105 10 gene gene NN cord-269353-wgeuh1i2 105 11 expression expression NN cord-269353-wgeuh1i2 105 12 levels level NNS cord-269353-wgeuh1i2 105 13 ( ( -LRB- cord-269353-wgeuh1i2 105 14 Chaney Chaney NNP cord-269353-wgeuh1i2 105 15 and and CC cord-269353-wgeuh1i2 105 16 Clark Clark NNP cord-269353-wgeuh1i2 105 17 2015 2015 CD cord-269353-wgeuh1i2 105 18 ; ; : cord-269353-wgeuh1i2 105 19 Zhou Zhou NNP cord-269353-wgeuh1i2 105 20 et et NNP cord-269353-wgeuh1i2 105 21 al al NNP cord-269353-wgeuh1i2 105 22 . . . cord-269353-wgeuh1i2 105 23 2016 2016 CD cord-269353-wgeuh1i2 105 24 ) ) -RRB- cord-269353-wgeuh1i2 105 25 . . . cord-269353-wgeuh1i2 106 1 Because because IN cord-269353-wgeuh1i2 106 2 viruses virus NNS cord-269353-wgeuh1i2 106 3 do do VBP cord-269353-wgeuh1i2 106 4 not not RB cord-269353-wgeuh1i2 106 5 have have VB cord-269353-wgeuh1i2 106 6 tRNAs trnas CD cord-269353-wgeuh1i2 106 7 , , , cord-269353-wgeuh1i2 106 8 and and CC cord-269353-wgeuh1i2 106 9 rely rely VB cord-269353-wgeuh1i2 106 10 on on IN cord-269353-wgeuh1i2 106 11 host host NN cord-269353-wgeuh1i2 106 12 cell cell NN cord-269353-wgeuh1i2 106 13 machinery machinery NN cord-269353-wgeuh1i2 106 14 for for IN cord-269353-wgeuh1i2 106 15 replication replication NN cord-269353-wgeuh1i2 106 16 , , , cord-269353-wgeuh1i2 106 17 co co NN cord-269353-wgeuh1i2 106 18 - - NN cord-269353-wgeuh1i2 106 19 evolution evolution NN cord-269353-wgeuh1i2 106 20 between between IN cord-269353-wgeuh1i2 106 21 a a DT cord-269353-wgeuh1i2 106 22 certain certain JJ cord-269353-wgeuh1i2 106 23 RNA RNA NNP cord-269353-wgeuh1i2 106 24 virus virus NN cord-269353-wgeuh1i2 106 25 and and CC cord-269353-wgeuh1i2 106 26 its -PRON- PRP$ cord-269353-wgeuh1i2 106 27 susceptible susceptible JJ cord-269353-wgeuh1i2 106 28 hosts host NNS cord-269353-wgeuh1i2 106 29 at at IN cord-269353-wgeuh1i2 106 30 codon codon NN cord-269353-wgeuh1i2 106 31 usages usage NNS cord-269353-wgeuh1i2 106 32 have have VBP cord-269353-wgeuh1i2 106 33 been be VBN cord-269353-wgeuh1i2 106 34 observed observe VBN cord-269353-wgeuh1i2 107 1 ( ( -LRB- cord-269353-wgeuh1i2 107 2 Franzo Franzo NNP cord-269353-wgeuh1i2 107 3 et et NNP cord-269353-wgeuh1i2 107 4 al al NNP cord-269353-wgeuh1i2 107 5 . . . cord-269353-wgeuh1i2 107 6 2017 2017 CD cord-269353-wgeuh1i2 108 1 ; ; : cord-269353-wgeuh1i2 108 2 Rahman Rahman NNP cord-269353-wgeuh1i2 108 3 et et NNP cord-269353-wgeuh1i2 108 4 al al NNP cord-269353-wgeuh1i2 108 5 . . . cord-269353-wgeuh1i2 108 6 2017 2017 CD cord-269353-wgeuh1i2 108 7 ; ; : cord-269353-wgeuh1i2 108 8 Simón Simón NNP cord-269353-wgeuh1i2 108 9 et et NNP cord-269353-wgeuh1i2 108 10 al al NNP cord-269353-wgeuh1i2 108 11 . . . cord-269353-wgeuh1i2 108 12 2017 2017 CD cord-269353-wgeuh1i2 108 13 ) ) -RRB- cord-269353-wgeuh1i2 108 14 . . . cord-269353-wgeuh1i2 109 1 However however RB cord-269353-wgeuh1i2 109 2 , , , cord-269353-wgeuh1i2 109 3 ambiguity ambiguity NN cord-269353-wgeuh1i2 109 4 remains remain VBZ cord-269353-wgeuh1i2 109 5 in in IN cord-269353-wgeuh1i2 109 6 the the DT cord-269353-wgeuh1i2 109 7 co co NN cord-269353-wgeuh1i2 109 8 - - JJ cord-269353-wgeuh1i2 109 9 evolution evolution JJ cord-269353-wgeuh1i2 109 10 patterns pattern NNS cord-269353-wgeuh1i2 109 11 of of IN cord-269353-wgeuh1i2 109 12 different different JJ cord-269353-wgeuh1i2 109 13 viruses virus NNS cord-269353-wgeuh1i2 109 14 . . . cord-269353-wgeuh1i2 110 1 Some some DT cord-269353-wgeuh1i2 110 2 viruses virus NNS cord-269353-wgeuh1i2 110 3 infect infect VBP cord-269353-wgeuh1i2 110 4 a a DT cord-269353-wgeuh1i2 110 5 broad broad JJ cord-269353-wgeuh1i2 110 6 range range NN cord-269353-wgeuh1i2 110 7 of of IN cord-269353-wgeuh1i2 110 8 species specie NNS cord-269353-wgeuh1i2 110 9 ( ( -LRB- cord-269353-wgeuh1i2 110 10 BSTVs bstv NNS cord-269353-wgeuh1i2 110 11 ) ) -RRB- cord-269353-wgeuh1i2 110 12 , , , cord-269353-wgeuh1i2 110 13 whereas whereas IN cord-269353-wgeuh1i2 110 14 others other NNS cord-269353-wgeuh1i2 110 15 infect infect VBP cord-269353-wgeuh1i2 110 16 only only RB cord-269353-wgeuh1i2 110 17 a a DT cord-269353-wgeuh1i2 110 18 single single JJ cord-269353-wgeuh1i2 110 19 host host NN cord-269353-wgeuh1i2 110 20 ( ( -LRB- cord-269353-wgeuh1i2 110 21 NSTVs nstv NNS cord-269353-wgeuh1i2 110 22 ) ) -RRB- cord-269353-wgeuh1i2 110 23 . . . cord-269353-wgeuh1i2 111 1 Viruses virus NNS cord-269353-wgeuh1i2 111 2 have have VBP cord-269353-wgeuh1i2 111 3 very very RB cord-269353-wgeuh1i2 111 4 diverse diverse JJ cord-269353-wgeuh1i2 111 5 hosts host NNS cord-269353-wgeuh1i2 111 6 , , , cord-269353-wgeuh1i2 111 7 and and CC cord-269353-wgeuh1i2 111 8 different different JJ cord-269353-wgeuh1i2 111 9 hosts host NNS cord-269353-wgeuh1i2 111 10 have have VBP cord-269353-wgeuh1i2 111 11 very very RB cord-269353-wgeuh1i2 111 12 diverse diverse JJ cord-269353-wgeuh1i2 111 13 tRNA trna NN cord-269353-wgeuh1i2 111 14 pools pool NNS cord-269353-wgeuh1i2 111 15 . . . cord-269353-wgeuh1i2 112 1 The the DT cord-269353-wgeuh1i2 112 2 MD MD NNP cord-269353-wgeuh1i2 112 3 and and CC cord-269353-wgeuh1i2 112 4 D D NNP cord-269353-wgeuh1i2 112 5 ( ( -LRB- cord-269353-wgeuh1i2 112 6 A a NN cord-269353-wgeuh1i2 112 7 , , , cord-269353-wgeuh1i2 112 8 B b NN cord-269353-wgeuh1i2 112 9 ) ) -RRB- cord-269353-wgeuh1i2 112 10 values value NNS cord-269353-wgeuh1i2 112 11 of of IN cord-269353-wgeuh1i2 112 12 NSTVs nstv NNS cord-269353-wgeuh1i2 112 13 are be VBP cord-269353-wgeuh1i2 112 14 significantly significantly RB cord-269353-wgeuh1i2 112 15 higher high JJR cord-269353-wgeuh1i2 112 16 than than IN cord-269353-wgeuh1i2 112 17 those those DT cord-269353-wgeuh1i2 112 18 of of IN cord-269353-wgeuh1i2 112 19 the the DT cord-269353-wgeuh1i2 112 20 BSTVs bstv NNS cord-269353-wgeuh1i2 112 21 vs. vs. IN cord-269353-wgeuh1i2 112 22 Anopheles Anopheles NNP cord-269353-wgeuh1i2 112 23 gambiae gambiae NN cord-269353-wgeuh1i2 112 24 , , , cord-269353-wgeuh1i2 112 25 Homo Homo NNP cord-269353-wgeuh1i2 112 26 sapiens sapiens JJ cord-269353-wgeuh1i2 112 27 , , , cord-269353-wgeuh1i2 112 28 Gallus Gallus NNP cord-269353-wgeuh1i2 112 29 gallus gallus NN cord-269353-wgeuh1i2 112 30 , , , cord-269353-wgeuh1i2 112 31 and and CC cord-269353-wgeuh1i2 112 32 Macaca Macaca NNP cord-269353-wgeuh1i2 112 33 mulatta mulatta NN cord-269353-wgeuh1i2 112 34 ( ( -LRB- cord-269353-wgeuh1i2 112 35 Figs fig NNS cord-269353-wgeuh1i2 112 36 . . . cord-269353-wgeuh1i2 113 1 1 1 CD cord-269353-wgeuh1i2 113 2 and and CC cord-269353-wgeuh1i2 113 3 2 2 CD cord-269353-wgeuh1i2 113 4 ) ) -RRB- cord-269353-wgeuh1i2 113 5 . . . cord-269353-wgeuh1i2 114 1 Thus thus RB cord-269353-wgeuh1i2 114 2 , , , cord-269353-wgeuh1i2 114 3 and and CC cord-269353-wgeuh1i2 114 4 as as IN cord-269353-wgeuh1i2 114 5 our -PRON- PRP$ cord-269353-wgeuh1i2 114 6 hypothesis hypothesis NN cord-269353-wgeuh1i2 114 7 predicts predict VBZ cord-269353-wgeuh1i2 114 8 , , , cord-269353-wgeuh1i2 114 9 NSTVs nstv NNS cord-269353-wgeuh1i2 114 10 appear appear VBP cord-269353-wgeuh1i2 114 11 to to TO cord-269353-wgeuh1i2 114 12 be be VB cord-269353-wgeuh1i2 114 13 more more RBR cord-269353-wgeuh1i2 114 14 precisely precisely RB cord-269353-wgeuh1i2 114 15 adapted adapt VBN cord-269353-wgeuh1i2 114 16 to to IN cord-269353-wgeuh1i2 114 17 their -PRON- PRP$ cord-269353-wgeuh1i2 114 18 hosts host NNS cord-269353-wgeuh1i2 114 19 ' ' POS cord-269353-wgeuh1i2 114 20 codon codon NN cord-269353-wgeuh1i2 114 21 usage usage NN cord-269353-wgeuh1i2 114 22 pattern pattern NN cord-269353-wgeuh1i2 114 23 and and CC cord-269353-wgeuh1i2 114 24 tRNA trna NN cord-269353-wgeuh1i2 114 25 pools pool NNS cord-269353-wgeuh1i2 114 26 than than IN cord-269353-wgeuh1i2 114 27 BSTVs bstv NNS cord-269353-wgeuh1i2 114 28 . . . cord-269353-wgeuh1i2 115 1 Each each DT cord-269353-wgeuh1i2 115 2 NSTV NSTV NNP cord-269353-wgeuh1i2 115 3 can can MD cord-269353-wgeuh1i2 115 4 infect infect VB cord-269353-wgeuh1i2 115 5 one one CD cord-269353-wgeuh1i2 115 6 host host NN cord-269353-wgeuh1i2 115 7 only only RB cord-269353-wgeuh1i2 115 8 . . . cord-269353-wgeuh1i2 116 1 Therefore therefore RB cord-269353-wgeuh1i2 116 2 , , , cord-269353-wgeuh1i2 116 3 these these DT cord-269353-wgeuh1i2 116 4 viruses virus NNS cord-269353-wgeuh1i2 116 5 need need VBP cord-269353-wgeuh1i2 116 6 to to TO cord-269353-wgeuh1i2 116 7 fit fit VB cord-269353-wgeuh1i2 116 8 only only RB cord-269353-wgeuh1i2 116 9 one one CD cord-269353-wgeuh1i2 116 10 host host NN cord-269353-wgeuh1i2 116 11 's 's POS cord-269353-wgeuh1i2 116 12 tRNA tRNA NNP cord-269353-wgeuh1i2 116 13 pool pool NN cord-269353-wgeuh1i2 116 14 . . . cord-269353-wgeuh1i2 117 1 They -PRON- PRP cord-269353-wgeuh1i2 117 2 appear appear VBP cord-269353-wgeuh1i2 117 3 to to TO cord-269353-wgeuh1i2 117 4 have have VB cord-269353-wgeuh1i2 117 5 evolved evolve VBN cord-269353-wgeuh1i2 117 6 more more RBR cord-269353-wgeuh1i2 117 7 consistent consistent JJ cord-269353-wgeuh1i2 117 8 codon codon NN cord-269353-wgeuh1i2 117 9 usage usage NN cord-269353-wgeuh1i2 117 10 patterns pattern NNS cord-269353-wgeuh1i2 117 11 with with IN cord-269353-wgeuh1i2 117 12 their -PRON- PRP$ cord-269353-wgeuh1i2 117 13 hosts host NNS cord-269353-wgeuh1i2 117 14 ' ' POS cord-269353-wgeuh1i2 117 15 expression expression NN cord-269353-wgeuh1i2 117 16 systems system NNS cord-269353-wgeuh1i2 117 17 . . . cord-269353-wgeuh1i2 118 1 In in IN cord-269353-wgeuh1i2 118 2 contrast contrast NN cord-269353-wgeuh1i2 118 3 , , , cord-269353-wgeuh1i2 118 4 BSTVs bstv NNS cord-269353-wgeuh1i2 118 5 can can MD cord-269353-wgeuh1i2 118 6 infect infect VB cord-269353-wgeuh1i2 118 7 and and CC cord-269353-wgeuh1i2 118 8 replicate replicate VB cord-269353-wgeuh1i2 118 9 in in IN cord-269353-wgeuh1i2 118 10 mammals mammal NNS cord-269353-wgeuh1i2 118 11 , , , cord-269353-wgeuh1i2 118 12 birds bird NNS cord-269353-wgeuh1i2 118 13 , , , cord-269353-wgeuh1i2 118 14 and and CC cord-269353-wgeuh1i2 118 15 insects insect NNS cord-269353-wgeuh1i2 118 16 . . . cord-269353-wgeuh1i2 119 1 Thus thus RB cord-269353-wgeuh1i2 119 2 , , , cord-269353-wgeuh1i2 119 3 adaptation adaptation NN cord-269353-wgeuh1i2 119 4 in in IN cord-269353-wgeuh1i2 119 5 BSTVs bstv NNS cord-269353-wgeuh1i2 119 6 may may MD cord-269353-wgeuh1i2 119 7 involve involve VB cord-269353-wgeuh1i2 119 8 a a DT cord-269353-wgeuh1i2 119 9 tradeoff tradeoff NN cord-269353-wgeuh1i2 119 10 between between IN cord-269353-wgeuh1i2 119 11 precise precise JJ cord-269353-wgeuh1i2 119 12 and and CC cord-269353-wgeuh1i2 119 13 functional functional JJ cord-269353-wgeuh1i2 119 14 matching matching NN cord-269353-wgeuh1i2 119 15 to to TO cord-269353-wgeuh1i2 119 16 fit fit VB cord-269353-wgeuh1i2 119 17 the the DT cord-269353-wgeuh1i2 119 18 diverse diverse JJ cord-269353-wgeuh1i2 119 19 tRNA tRNA NNP cord-269353-wgeuh1i2 119 20 pools pool NNS cord-269353-wgeuh1i2 119 21 of of IN cord-269353-wgeuh1i2 119 22 multiple multiple JJ cord-269353-wgeuh1i2 119 23 hosts host NNS cord-269353-wgeuh1i2 119 24 . . . cord-269353-wgeuh1i2 120 1 This this DT cord-269353-wgeuh1i2 120 2 may may MD cord-269353-wgeuh1i2 120 3 explain explain VB cord-269353-wgeuh1i2 120 4 the the DT cord-269353-wgeuh1i2 120 5 relatively relatively RB cord-269353-wgeuh1i2 120 6 lower low JJR cord-269353-wgeuh1i2 120 7 matching matching NN cord-269353-wgeuh1i2 120 8 of of IN cord-269353-wgeuh1i2 120 9 BSTVs bstv NNS cord-269353-wgeuh1i2 120 10 to to IN cord-269353-wgeuh1i2 120 11 their -PRON- PRP$ cord-269353-wgeuh1i2 120 12 hosts host NNS cord-269353-wgeuh1i2 120 13 . . . cord-269353-wgeuh1i2 121 1 Enterovirus enterovirus NN cord-269353-wgeuh1i2 121 2 , , , cord-269353-wgeuh1i2 121 3 Hepacivirus Hepacivirus NNP cord-269353-wgeuh1i2 121 4 and and CC cord-269353-wgeuh1i2 121 5 Arterivirus Arterivirus NNP cord-269353-wgeuh1i2 121 6 are be VBP cord-269353-wgeuh1i2 121 7 NSTVs nstv NNS cord-269353-wgeuh1i2 121 8 and and CC cord-269353-wgeuh1i2 121 9 their -PRON- PRP$ cord-269353-wgeuh1i2 121 10 D(A d(a NN cord-269353-wgeuh1i2 121 11 , , , cord-269353-wgeuh1i2 121 12 B b NN cord-269353-wgeuh1i2 121 13 ) ) -RRB- cord-269353-wgeuh1i2 121 14 values value NNS cord-269353-wgeuh1i2 121 15 are be VBP cord-269353-wgeuh1i2 121 16 relatively relatively RB cord-269353-wgeuh1i2 121 17 low low JJ cord-269353-wgeuh1i2 122 1 ( ( -LRB- cord-269353-wgeuh1i2 122 2 Fig Fig NNP cord-269353-wgeuh1i2 122 3 . . . cord-269353-wgeuh1i2 122 4 2b 2b NNP cord-269353-wgeuh1i2 122 5 ) ) -RRB- cord-269353-wgeuh1i2 122 6 . . . cord-269353-wgeuh1i2 123 1 This this DT cord-269353-wgeuh1i2 123 2 indicates indicate VBZ cord-269353-wgeuh1i2 123 3 a a DT cord-269353-wgeuh1i2 123 4 relatively relatively RB cord-269353-wgeuh1i2 123 5 low low JJ cord-269353-wgeuh1i2 123 6 extent extent NN cord-269353-wgeuh1i2 123 7 of of IN cord-269353-wgeuh1i2 123 8 similarity similarity NN cord-269353-wgeuh1i2 123 9 in in IN cord-269353-wgeuh1i2 123 10 overall overall JJ cord-269353-wgeuh1i2 123 11 codon codon NN cord-269353-wgeuh1i2 123 12 usage usage NN cord-269353-wgeuh1i2 123 13 between between IN cord-269353-wgeuh1i2 123 14 these these DT cord-269353-wgeuh1i2 123 15 viruses virus NNS cord-269353-wgeuh1i2 123 16 and and CC cord-269353-wgeuh1i2 123 17 their -PRON- PRP$ cord-269353-wgeuh1i2 123 18 host host NN cord-269353-wgeuh1i2 123 19 . . . cord-269353-wgeuh1i2 124 1 These these DT cord-269353-wgeuh1i2 124 2 viruses virus NNS cord-269353-wgeuh1i2 124 3 may may MD cord-269353-wgeuh1i2 124 4 not not RB cord-269353-wgeuh1i2 124 5 need need VB cord-269353-wgeuh1i2 124 6 to to TO cord-269353-wgeuh1i2 124 7 replicate replicate VB cord-269353-wgeuh1i2 124 8 rapidly rapidly RB cord-269353-wgeuh1i2 124 9 . . . cord-269353-wgeuh1i2 125 1 Other other JJ cord-269353-wgeuh1i2 125 2 factors factor NNS cord-269353-wgeuh1i2 125 3 , , , cord-269353-wgeuh1i2 125 4 such such JJ cord-269353-wgeuh1i2 125 5 as as IN cord-269353-wgeuh1i2 125 6 mutational mutational JJ cord-269353-wgeuh1i2 125 7 pressure pressure NN cord-269353-wgeuh1i2 125 8 , , , cord-269353-wgeuh1i2 125 9 may may MD cord-269353-wgeuh1i2 125 10 also also RB cord-269353-wgeuh1i2 125 11 play play VB cord-269353-wgeuh1i2 125 12 a a DT cord-269353-wgeuh1i2 125 13 role role NN cord-269353-wgeuh1i2 125 14 in in IN cord-269353-wgeuh1i2 125 15 determining determine VBG cord-269353-wgeuh1i2 125 16 codon codon NN cord-269353-wgeuh1i2 125 17 usage usage NN cord-269353-wgeuh1i2 125 18 bias bias NN cord-269353-wgeuh1i2 125 19 ( ( -LRB- cord-269353-wgeuh1i2 125 20 Gu Gu NNP cord-269353-wgeuh1i2 125 21 et et FW cord-269353-wgeuh1i2 125 22 al al NNP cord-269353-wgeuh1i2 125 23 . . . cord-269353-wgeuh1i2 125 24 2004 2004 CD cord-269353-wgeuh1i2 125 25 ; ; : cord-269353-wgeuh1i2 125 26 Rahman Rahman NNP cord-269353-wgeuh1i2 125 27 et et NNP cord-269353-wgeuh1i2 125 28 al al NNP cord-269353-wgeuh1i2 125 29 . . . cord-269353-wgeuh1i2 125 30 2017 2017 CD cord-269353-wgeuh1i2 125 31 ; ; : cord-269353-wgeuh1i2 125 32 Wang Wang NNP cord-269353-wgeuh1i2 125 33 et et NNP cord-269353-wgeuh1i2 125 34 al al NNP cord-269353-wgeuh1i2 125 35 . . NNP cord-269353-wgeuh1i2 125 36 2011 2011 CD cord-269353-wgeuh1i2 125 37 ; ; : cord-269353-wgeuh1i2 125 38 Wong Wong NNP cord-269353-wgeuh1i2 125 39 et et NNP cord-269353-wgeuh1i2 125 40 al al NNP cord-269353-wgeuh1i2 125 41 . . NNP cord-269353-wgeuh1i2 125 42 2010 2010 CD cord-269353-wgeuh1i2 125 43 ) ) -RRB- cord-269353-wgeuh1i2 125 44 . . . cord-269353-wgeuh1i2 126 1 To to TO cord-269353-wgeuh1i2 126 2 quantify quantify VB cord-269353-wgeuh1i2 126 3 the the DT cord-269353-wgeuh1i2 126 4 extent extent NN cord-269353-wgeuh1i2 126 5 of of IN cord-269353-wgeuh1i2 126 6 variation variation NN cord-269353-wgeuh1i2 126 7 in in IN cord-269353-wgeuh1i2 126 8 codon codon NN cord-269353-wgeuh1i2 126 9 usage usage NN cord-269353-wgeuh1i2 126 10 , , , cord-269353-wgeuh1i2 126 11 the the DT cord-269353-wgeuh1i2 126 12 ENc enc NN cord-269353-wgeuh1i2 126 13 values value NNS cord-269353-wgeuh1i2 126 14 were be VBD cord-269353-wgeuh1i2 126 15 calculated calculate VBN cord-269353-wgeuh1i2 126 16 ( ( -LRB- cord-269353-wgeuh1i2 126 17 Wright Wright NNP cord-269353-wgeuh1i2 126 18 1990 1990 CD cord-269353-wgeuh1i2 126 19 ) ) -RRB- cord-269353-wgeuh1i2 126 20 . . . cord-269353-wgeuh1i2 127 1 Most Most JJS cord-269353-wgeuh1i2 127 2 viruses virus NNS cord-269353-wgeuh1i2 127 3 have have VBP cord-269353-wgeuh1i2 127 4 ENC ENC NNP cord-269353-wgeuh1i2 127 5 values value NNS cord-269353-wgeuh1i2 127 6 > > XX cord-269353-wgeuh1i2 127 7 40 40 CD cord-269353-wgeuh1i2 127 8 , , , cord-269353-wgeuh1i2 127 9 which which WDT cord-269353-wgeuh1i2 127 10 represents represent VBZ cord-269353-wgeuh1i2 127 11 weak weak JJ cord-269353-wgeuh1i2 127 12 codon codon NN cord-269353-wgeuh1i2 127 13 bias bias NN cord-269353-wgeuh1i2 127 14 . . . cord-269353-wgeuh1i2 128 1 This this DT cord-269353-wgeuh1i2 128 2 may may MD cord-269353-wgeuh1i2 128 3 be be VB cord-269353-wgeuh1i2 128 4 beneficial beneficial JJ cord-269353-wgeuh1i2 128 5 for for IN cord-269353-wgeuh1i2 128 6 efficient efficient JJ cord-269353-wgeuh1i2 128 7 replication replication NN cord-269353-wgeuh1i2 128 8 of of IN cord-269353-wgeuh1i2 128 9 viruses virus NNS cord-269353-wgeuh1i2 128 10 in in IN cord-269353-wgeuh1i2 128 11 host host NN cord-269353-wgeuh1i2 128 12 cells cell NNS cord-269353-wgeuh1i2 128 13 with with IN cord-269353-wgeuh1i2 128 14 potentially potentially RB cord-269353-wgeuh1i2 128 15 distinct distinct JJ cord-269353-wgeuh1i2 128 16 codon codon NN cord-269353-wgeuh1i2 128 17 preferences preference NNS cord-269353-wgeuh1i2 128 18 . . . cord-269353-wgeuh1i2 129 1 The the DT cord-269353-wgeuh1i2 129 2 codon codon NN cord-269353-wgeuh1i2 129 3 preference preference NN cord-269353-wgeuh1i2 129 4 of of IN cord-269353-wgeuh1i2 129 5 NSTVs nstv NNS cord-269353-wgeuh1i2 129 6 is be VBZ cord-269353-wgeuh1i2 129 7 relatively relatively RB cord-269353-wgeuh1i2 129 8 stronger strong JJR cord-269353-wgeuh1i2 129 9 than than IN cord-269353-wgeuh1i2 129 10 for for IN cord-269353-wgeuh1i2 129 11 BSTVs bstv NNS cord-269353-wgeuh1i2 129 12 ( ( -LRB- cord-269353-wgeuh1i2 129 13 Fig Fig NNP cord-269353-wgeuh1i2 129 14 . . . cord-269353-wgeuh1i2 129 15 3 3 CD cord-269353-wgeuh1i2 129 16 ) ) -RRB- cord-269353-wgeuh1i2 129 17 . . . cord-269353-wgeuh1i2 130 1 This this DT cord-269353-wgeuh1i2 130 2 is be VBZ cord-269353-wgeuh1i2 130 3 could could MD cord-269353-wgeuh1i2 130 4 be be VB cord-269353-wgeuh1i2 130 5 due due JJ cord-269353-wgeuh1i2 130 6 to to IN cord-269353-wgeuh1i2 130 7 weak weak JJ cord-269353-wgeuh1i2 130 8 codon codon NN cord-269353-wgeuh1i2 130 9 preference preference NN cord-269353-wgeuh1i2 130 10 being be VBG cord-269353-wgeuh1i2 130 11 advantageous advantageous JJ cord-269353-wgeuh1i2 130 12 in in IN cord-269353-wgeuh1i2 130 13 the the DT cord-269353-wgeuh1i2 130 14 adaptation adaptation NN cord-269353-wgeuh1i2 130 15 of of IN cord-269353-wgeuh1i2 130 16 BSTVs bstv NNS cord-269353-wgeuh1i2 130 17 to to IN cord-269353-wgeuh1i2 130 18 multiple multiple JJ cord-269353-wgeuh1i2 130 19 host host NN cord-269353-wgeuh1i2 130 20 expression expression NN cord-269353-wgeuh1i2 130 21 systems system NNS cord-269353-wgeuh1i2 130 22 . . . cord-269353-wgeuh1i2 131 1 The the DT cord-269353-wgeuh1i2 131 2 ability ability NN cord-269353-wgeuh1i2 131 3 to to TO cord-269353-wgeuh1i2 131 4 enter enter VB cord-269353-wgeuh1i2 131 5 the the DT cord-269353-wgeuh1i2 131 6 host host NN cord-269353-wgeuh1i2 131 7 - - HYPH cord-269353-wgeuh1i2 131 8 cell cell NN cord-269353-wgeuh1i2 131 9 and and CC cord-269353-wgeuh1i2 131 10 efficiently efficiently RB cord-269353-wgeuh1i2 131 11 replicate replicate VB cord-269353-wgeuh1i2 131 12 itself -PRON- PRP cord-269353-wgeuh1i2 131 13 is be VBZ cord-269353-wgeuh1i2 131 14 essential essential JJ cord-269353-wgeuh1i2 131 15 for for IN cord-269353-wgeuh1i2 131 16 viral viral JJ cord-269353-wgeuh1i2 131 17 infection infection NN cord-269353-wgeuh1i2 131 18 . . . cord-269353-wgeuh1i2 132 1 Viruses virus NNS cord-269353-wgeuh1i2 132 2 have have VBP cord-269353-wgeuh1i2 132 3 coevolved coevolve VBN cord-269353-wgeuh1i2 132 4 many many JJ cord-269353-wgeuh1i2 132 5 pathways pathway NNS cord-269353-wgeuh1i2 132 6 to to TO cord-269353-wgeuh1i2 132 7 transcribe transcribe VB cord-269353-wgeuh1i2 132 8 their -PRON- PRP$ cord-269353-wgeuh1i2 132 9 own own JJ cord-269353-wgeuh1i2 132 10 genetic genetic JJ cord-269353-wgeuh1i2 132 11 material material NN cord-269353-wgeuh1i2 132 12 in in IN cord-269353-wgeuh1i2 132 13 their -PRON- PRP$ cord-269353-wgeuh1i2 132 14 hosts host NNS cord-269353-wgeuh1i2 133 1 ( ( -LRB- cord-269353-wgeuh1i2 133 2 Harwig Harwig NNP cord-269353-wgeuh1i2 133 3 et et NNP cord-269353-wgeuh1i2 133 4 al al NNP cord-269353-wgeuh1i2 133 5 . . . cord-269353-wgeuh1i2 133 6 2017 2017 CD cord-269353-wgeuh1i2 133 7 ) ) -RRB- cord-269353-wgeuh1i2 133 8 . . . cord-269353-wgeuh1i2 134 1 Codon codon NN cord-269353-wgeuh1i2 134 2 usage usage NN cord-269353-wgeuh1i2 134 3 in in IN cord-269353-wgeuh1i2 134 4 BSTVs bstv NNS cord-269353-wgeuh1i2 134 5 may may MD cord-269353-wgeuh1i2 134 6 involve involve VB cord-269353-wgeuh1i2 134 7 a a DT cord-269353-wgeuh1i2 134 8 tradeoff tradeoff NN cord-269353-wgeuh1i2 134 9 between between IN cord-269353-wgeuh1i2 134 10 precise precise JJ cord-269353-wgeuh1i2 134 11 and and CC cord-269353-wgeuh1i2 134 12 functional functional JJ cord-269353-wgeuh1i2 134 13 matching matching NN cord-269353-wgeuh1i2 134 14 to to TO cord-269353-wgeuh1i2 134 15 fit fit VB cord-269353-wgeuh1i2 134 16 the the DT cord-269353-wgeuh1i2 134 17 diverse diverse JJ cord-269353-wgeuh1i2 134 18 tRNA tRNA NNP cord-269353-wgeuh1i2 134 19 pools pool NNS cord-269353-wgeuh1i2 134 20 of of IN cord-269353-wgeuh1i2 134 21 multiple multiple JJ cord-269353-wgeuh1i2 134 22 hosts host NNS cord-269353-wgeuh1i2 134 23 . . . cord-269353-wgeuh1i2 135 1 As as IN cord-269353-wgeuh1i2 135 2 expected expect VBN cord-269353-wgeuh1i2 135 3 , , , cord-269353-wgeuh1i2 135 4 our -PRON- PRP$ cord-269353-wgeuh1i2 135 5 analysis analysis NN cord-269353-wgeuh1i2 135 6 show show VBP cord-269353-wgeuh1i2 135 7 that that IN cord-269353-wgeuh1i2 135 8 generally generally RB cord-269353-wgeuh1i2 135 9 NSTVs nstv NNS cord-269353-wgeuh1i2 135 10 are be VBP cord-269353-wgeuh1i2 135 11 more more RBR cord-269353-wgeuh1i2 135 12 adapted adapt VBN cord-269353-wgeuh1i2 135 13 to to IN cord-269353-wgeuh1i2 135 14 their -PRON- PRP$ cord-269353-wgeuh1i2 135 15 hosts host NNS cord-269353-wgeuh1i2 135 16 ' ' POS cord-269353-wgeuh1i2 135 17 codon codon NN cord-269353-wgeuh1i2 135 18 usage usage NN cord-269353-wgeuh1i2 135 19 pattern pattern NN cord-269353-wgeuh1i2 135 20 and and CC cord-269353-wgeuh1i2 135 21 tRNA trna NN cord-269353-wgeuh1i2 135 22 pools pool NNS cord-269353-wgeuh1i2 135 23 than than IN cord-269353-wgeuh1i2 135 24 BSTVs bstv NNS cord-269353-wgeuh1i2 135 25 . . . cord-269353-wgeuh1i2 136 1 This this DT cord-269353-wgeuh1i2 136 2 may may MD cord-269353-wgeuh1i2 136 3 help help VB cord-269353-wgeuh1i2 136 4 the the DT cord-269353-wgeuh1i2 136 5 virus virus NN cord-269353-wgeuh1i2 136 6 to to TO cord-269353-wgeuh1i2 136 7 use use VB cord-269353-wgeuh1i2 136 8 the the DT cord-269353-wgeuh1i2 136 9 host host NN cord-269353-wgeuh1i2 136 10 transcript transcript NN cord-269353-wgeuh1i2 136 11 machinery machinery NN cord-269353-wgeuh1i2 136 12 more more RBR cord-269353-wgeuh1i2 136 13 efficiently efficiently RB cord-269353-wgeuh1i2 136 14 and and CC cord-269353-wgeuh1i2 136 15 , , , cord-269353-wgeuh1i2 136 16 therefore therefore RB cord-269353-wgeuh1i2 136 17 , , , cord-269353-wgeuh1i2 136 18 replicate replicate VBP cord-269353-wgeuh1i2 136 19 faster fast RBR cord-269353-wgeuh1i2 136 20 . . . cord-269353-wgeuh1i2 137 1 Supplementary supplementary JJ cord-269353-wgeuh1i2 137 2 data datum NNS cord-269353-wgeuh1i2 137 3 to to IN cord-269353-wgeuh1i2 137 4 this this DT cord-269353-wgeuh1i2 137 5 article article NN cord-269353-wgeuh1i2 137 6 can can MD cord-269353-wgeuh1i2 137 7 be be VB cord-269353-wgeuh1i2 137 8 found find VBN cord-269353-wgeuh1i2 137 9 online online RB cord-269353-wgeuh1i2 137 10 at at IN cord-269353-wgeuh1i2 137 11 https:// https:// NNP cord-269353-wgeuh1i2 137 12 doi.org/10.1016/j.meegid.2018.05.034 doi.org/10.1016/j.meegid.2018.05.034 NNP cord-269353-wgeuh1i2 137 13 . . . cord-269353-wgeuh1i2 138 1 ( ( -LRB- cord-269353-wgeuh1i2 138 2 a a LS cord-269353-wgeuh1i2 138 3 ) ) -RRB- cord-269353-wgeuh1i2 138 4 Group group NN cord-269353-wgeuh1i2 138 5 1 1 CD cord-269353-wgeuh1i2 138 6 is be VBZ cord-269353-wgeuh1i2 138 7 the the DT cord-269353-wgeuh1i2 138 8 similarity similarity NN cord-269353-wgeuh1i2 138 9 degree degree NN cord-269353-wgeuh1i2 138 10 between between IN cord-269353-wgeuh1i2 138 11 BSTVs bstv NNS cord-269353-wgeuh1i2 138 12 and and CC cord-269353-wgeuh1i2 138 13 arthropods arthropod NNS cord-269353-wgeuh1i2 138 14 . . . cord-269353-wgeuh1i2 139 1 Group group NN cord-269353-wgeuh1i2 139 2 2 2 CD cord-269353-wgeuh1i2 139 3 is be VBZ cord-269353-wgeuh1i2 139 4 the the DT cord-269353-wgeuh1i2 139 5 similarity similarity NN cord-269353-wgeuh1i2 139 6 degree degree NN cord-269353-wgeuh1i2 139 7 between between IN cord-269353-wgeuh1i2 139 8 BSTVs bstv NNS cord-269353-wgeuh1i2 139 9 and and CC cord-269353-wgeuh1i2 139 10 mammals mammal NNS cord-269353-wgeuh1i2 139 11 . . . cord-269353-wgeuh1i2 140 1 Group group NN cord-269353-wgeuh1i2 140 2 3 3 CD cord-269353-wgeuh1i2 140 3 is be VBZ cord-269353-wgeuh1i2 140 4 the the DT cord-269353-wgeuh1i2 140 5 similarity similarity NN cord-269353-wgeuh1i2 140 6 degree degree NN cord-269353-wgeuh1i2 140 7 between between IN cord-269353-wgeuh1i2 140 8 BSTVs bstv NNS cord-269353-wgeuh1i2 140 9 and and CC cord-269353-wgeuh1i2 140 10 Gallus Gallus NNP cord-269353-wgeuh1i2 140 11 gallus gallus NN cord-269353-wgeuh1i2 140 12 . . . cord-269353-wgeuh1i2 141 1 Group group NN cord-269353-wgeuh1i2 141 2 4 4 CD cord-269353-wgeuh1i2 141 3 is be VBZ cord-269353-wgeuh1i2 141 4 the the DT cord-269353-wgeuh1i2 141 5 similarity similarity NN cord-269353-wgeuh1i2 141 6 degree degree NN cord-269353-wgeuh1i2 141 7 between between IN cord-269353-wgeuh1i2 141 8 NSTVs nstv NNS cord-269353-wgeuh1i2 141 9 and and CC cord-269353-wgeuh1i2 141 10 a a DT cord-269353-wgeuh1i2 141 11 particular particular JJ cord-269353-wgeuh1i2 141 12 host host NN cord-269353-wgeuh1i2 141 13 . . . cord-269353-wgeuh1i2 142 1 ( ( -LRB- cord-269353-wgeuh1i2 142 2 b b NN cord-269353-wgeuh1i2 142 3 ) ) -RRB- cord-269353-wgeuh1i2 143 1 The the DT cord-269353-wgeuh1i2 143 2 similarity similarity NN cord-269353-wgeuh1i2 143 3 degree degree NN cord-269353-wgeuh1i2 143 4 of of IN cord-269353-wgeuh1i2 143 5 the the DT cord-269353-wgeuh1i2 143 6 overall overall JJ cord-269353-wgeuh1i2 143 7 codon codon NN cord-269353-wgeuh1i2 143 8 usage usage NN cord-269353-wgeuh1i2 143 9 bias bias NN cord-269353-wgeuh1i2 143 10 between between IN cord-269353-wgeuh1i2 143 11 20 20 CD cord-269353-wgeuh1i2 143 12 virus virus NN cord-269353-wgeuh1i2 143 13 genera genus NNS cord-269353-wgeuh1i2 143 14 ( ( -LRB- cord-269353-wgeuh1i2 143 15 + + CC cord-269353-wgeuh1i2 143 16 ssRNA ssrna NN cord-269353-wgeuh1i2 143 17 ) ) -RRB- cord-269353-wgeuh1i2 143 18 and and CC cord-269353-wgeuh1i2 143 19 the the DT cord-269353-wgeuh1i2 143 20 hosts host NNS cord-269353-wgeuh1i2 143 21 . . . cord-269353-wgeuh1i2 144 1 YS YS NNP cord-269353-wgeuh1i2 144 2 : : : cord-269353-wgeuh1i2 144 3 designed design VBN cord-269353-wgeuh1i2 144 4 the the DT cord-269353-wgeuh1i2 144 5 study study NN cord-269353-wgeuh1i2 144 6 ; ; : cord-269353-wgeuh1i2 144 7 LT LT NNP cord-269353-wgeuh1i2 144 8 and and CC cord-269353-wgeuh1i2 144 9 XS XS NNP cord-269353-wgeuh1i2 144 10 : : : cord-269353-wgeuh1i2 144 11 analyzed analyze VBD cord-269353-wgeuh1i2 144 12 the the DT cord-269353-wgeuh1i2 144 13 data datum NNS cord-269353-wgeuh1i2 144 14 ; ; : cord-269353-wgeuh1i2 144 15 LT LT NNP cord-269353-wgeuh1i2 144 16 , , , cord-269353-wgeuh1i2 144 17 RWM RWM NNP cord-269353-wgeuh1i2 144 18 and and CC cord-269353-wgeuh1i2 144 19 YS YS NNP cord-269353-wgeuh1i2 144 20 : : : cord-269353-wgeuh1i2 144 21 drafted draft VBD cord-269353-wgeuh1i2 144 22 the the DT cord-269353-wgeuh1i2 144 23 manuscript manuscript NN cord-269353-wgeuh1i2 144 24 ; ; : cord-269353-wgeuh1i2 144 25 All all DT cord-269353-wgeuh1i2 144 26 authors author NNS cord-269353-wgeuh1i2 144 27 read read VBP cord-269353-wgeuh1i2 144 28 and and CC cord-269353-wgeuh1i2 144 29 approved approve VBD cord-269353-wgeuh1i2 144 30 the the DT cord-269353-wgeuh1i2 144 31 final final JJ cord-269353-wgeuh1i2 144 32 manuscript manuscript NN cord-269353-wgeuh1i2 144 33 . . . cord-269353-wgeuh1i2 144 34 _SP cord-269353-wgeuh1i2 145 1 Modulation modulation NN cord-269353-wgeuh1i2 145 2 of of IN cord-269353-wgeuh1i2 145 3 poliovirus poliovirus NN cord-269353-wgeuh1i2 145 4 replicative replicative JJ cord-269353-wgeuh1i2 145 5 fitness fitness NN cord-269353-wgeuh1i2 145 6 in in IN cord-269353-wgeuh1i2 145 7 HeLa HeLa NNP cord-269353-wgeuh1i2 145 8 cells cell NNS cord-269353-wgeuh1i2 145 9 by by IN cord-269353-wgeuh1i2 145 10 deoptimization deoptimization NN cord-269353-wgeuh1i2 145 11 of of IN cord-269353-wgeuh1i2 145 12 synonymous synonymous JJ cord-269353-wgeuh1i2 145 13 codon codon NN cord-269353-wgeuh1i2 145 14 usage usage NN cord-269353-wgeuh1i2 145 15 in in IN cord-269353-wgeuh1i2 145 16 the the DT cord-269353-wgeuh1i2 145 17 capsid capsid JJ cord-269353-wgeuh1i2 145 18 region region NN cord-269353-wgeuh1i2 145 19 Genome genome NN cord-269353-wgeuh1i2 145 20 - - HYPH cord-269353-wgeuh1i2 145 21 wide wide JJ cord-269353-wgeuh1i2 145 22 analysis analysis NN cord-269353-wgeuh1i2 145 23 of of IN cord-269353-wgeuh1i2 145 24 codon codon NN cord-269353-wgeuh1i2 145 25 usage usage NN cord-269353-wgeuh1i2 145 26 and and CC cord-269353-wgeuh1i2 145 27 influencing influence VBG cord-269353-wgeuh1i2 145 28 factors factor NNS cord-269353-wgeuh1i2 145 29 in in IN cord-269353-wgeuh1i2 145 30 chikungunya chikungunya NN cord-269353-wgeuh1i2 145 31 viruses virus NNS cord-269353-wgeuh1i2 145 32 Genome genome NN cord-269353-wgeuh1i2 145 33 - - HYPH cord-269353-wgeuh1i2 145 34 wide wide JJ cord-269353-wgeuh1i2 145 35 analysis analysis NN cord-269353-wgeuh1i2 145 36 of of IN cord-269353-wgeuh1i2 145 37 codon codon NN cord-269353-wgeuh1i2 145 38 usage usage NN cord-269353-wgeuh1i2 145 39 bias bias NN cord-269353-wgeuh1i2 145 40 in in IN cord-269353-wgeuh1i2 145 41 Bovine bovine JJ cord-269353-wgeuh1i2 145 42 Coronavirus Coronavirus NNP cord-269353-wgeuh1i2 145 43 Roles Roles NNPS cord-269353-wgeuh1i2 145 44 for for IN cord-269353-wgeuh1i2 145 45 synonymous synonymous JJ cord-269353-wgeuh1i2 145 46 codon codon NN cord-269353-wgeuh1i2 145 47 usage usage NN cord-269353-wgeuh1i2 145 48 in in IN cord-269353-wgeuh1i2 145 49 protein protein NN cord-269353-wgeuh1i2 145 50 biogenesis biogenesis NN cord-269353-wgeuh1i2 146 1 The the DT cord-269353-wgeuh1i2 146 2 effect effect NN cord-269353-wgeuh1i2 146 3 of of IN cord-269353-wgeuh1i2 146 4 mutation mutation NN cord-269353-wgeuh1i2 146 5 and and CC cord-269353-wgeuh1i2 146 6 selection selection NN cord-269353-wgeuh1i2 146 7 on on IN cord-269353-wgeuh1i2 146 8 codon codon NN cord-269353-wgeuh1i2 146 9 adaptation adaptation NN cord-269353-wgeuh1i2 146 10 in in IN cord-269353-wgeuh1i2 146 11 Escherichia Escherichia NNP cord-269353-wgeuh1i2 146 12 coli coli NNS cord-269353-wgeuh1i2 146 13 bacteriophage bacteriophage NN cord-269353-wgeuh1i2 147 1 Hepatitis Hepatitis NNP cord-269353-wgeuh1i2 147 2 A a DT cord-269353-wgeuh1i2 147 3 virus virus NN cord-269353-wgeuh1i2 147 4 adaptation adaptation NN cord-269353-wgeuh1i2 147 5 to to IN cord-269353-wgeuh1i2 147 6 cellular cellular JJ cord-269353-wgeuh1i2 147 7 shutoff shutoff NN cord-269353-wgeuh1i2 147 8 is be VBZ cord-269353-wgeuh1i2 147 9 driven drive VBN cord-269353-wgeuh1i2 147 10 by by IN cord-269353-wgeuh1i2 147 11 dynamic dynamic JJ cord-269353-wgeuh1i2 147 12 adjustments adjustment NNS cord-269353-wgeuh1i2 147 13 of of IN cord-269353-wgeuh1i2 147 14 codon codon NN cord-269353-wgeuh1i2 147 15 usage usage NN cord-269353-wgeuh1i2 147 16 and and CC cord-269353-wgeuh1i2 147 17 results result NNS cord-269353-wgeuh1i2 147 18 in in IN cord-269353-wgeuh1i2 147 19 the the DT cord-269353-wgeuh1i2 147 20 selection selection NN cord-269353-wgeuh1i2 147 21 of of IN cord-269353-wgeuh1i2 147 22 populations population NNS cord-269353-wgeuh1i2 147 23 with with IN cord-269353-wgeuh1i2 147 24 altered alter VBN cord-269353-wgeuh1i2 147 25 capsids capsid NNS cord-269353-wgeuh1i2 148 1 A a DT cord-269353-wgeuh1i2 148 2 detailed detailed JJ cord-269353-wgeuh1i2 148 3 comparative comparative JJ cord-269353-wgeuh1i2 148 4 analysis analysis NN cord-269353-wgeuh1i2 148 5 of of IN cord-269353-wgeuh1i2 148 6 codon codon NN cord-269353-wgeuh1i2 148 7 usage usage NN cord-269353-wgeuh1i2 148 8 bias bias NN cord-269353-wgeuh1i2 148 9 in in IN cord-269353-wgeuh1i2 148 10 Zika Zika NNP cord-269353-wgeuh1i2 148 11 virus virus NN cord-269353-wgeuh1i2 148 12 Canine canine JJ cord-269353-wgeuh1i2 148 13 parvovirus parvovirus NN cord-269353-wgeuh1i2 148 14 type type NN cord-269353-wgeuh1i2 148 15 2 2 CD cord-269353-wgeuh1i2 148 16 ( ( -LRB- cord-269353-wgeuh1i2 148 17 CPV-2 CPV-2 NNP cord-269353-wgeuh1i2 148 18 ) ) -RRB- cord-269353-wgeuh1i2 148 19 and and CC cord-269353-wgeuh1i2 149 1 Feline feline JJ cord-269353-wgeuh1i2 149 2 panleukopenia panleukopenia NNP cord-269353-wgeuh1i2 149 3 virus virus NN cord-269353-wgeuh1i2 149 4 ( ( -LRB- cord-269353-wgeuh1i2 149 5 FPV FPV NNP cord-269353-wgeuh1i2 149 6 ) ) -RRB- cord-269353-wgeuh1i2 149 7 codon codon NNP cord-269353-wgeuh1i2 149 8 bias bias NN cord-269353-wgeuh1i2 149 9 analysis analysis NN cord-269353-wgeuh1i2 149 10 reveals reveal VBZ cord-269353-wgeuh1i2 149 11 a a DT cord-269353-wgeuh1i2 149 12 progressive progressive JJ cord-269353-wgeuh1i2 149 13 adaptation adaptation NN cord-269353-wgeuh1i2 149 14 to to IN cord-269353-wgeuh1i2 149 15 the the DT cord-269353-wgeuh1i2 149 16 new new JJ cord-269353-wgeuh1i2 149 17 niche niche NN cord-269353-wgeuh1i2 149 18 after after IN cord-269353-wgeuh1i2 149 19 the the DT cord-269353-wgeuh1i2 149 20 host host NN cord-269353-wgeuh1i2 149 21 jump jump NN cord-269353-wgeuh1i2 149 22 Analysis Analysis NNP cord-269353-wgeuh1i2 149 23 of of IN cord-269353-wgeuh1i2 149 24 synonymous synonymous JJ cord-269353-wgeuh1i2 149 25 codon codon NN cord-269353-wgeuh1i2 149 26 usage usage NN cord-269353-wgeuh1i2 149 27 in in IN cord-269353-wgeuh1i2 149 28 SARS SARS NNP cord-269353-wgeuh1i2 149 29 Coronavirus Coronavirus NNP cord-269353-wgeuh1i2 149 30 and and CC cord-269353-wgeuh1i2 149 31 other other JJ cord-269353-wgeuh1i2 149 32 viruses virus NNS cord-269353-wgeuh1i2 149 33 in in IN cord-269353-wgeuh1i2 149 34 the the DT cord-269353-wgeuh1i2 149 35 Nidovirales Nidovirales NNP cord-269353-wgeuh1i2 150 1 The the DT cord-269353-wgeuh1i2 150 2 battle battle NN cord-269353-wgeuh1i2 150 3 of of IN cord-269353-wgeuh1i2 150 4 RNA RNA NNP cord-269353-wgeuh1i2 150 5 synthesis synthesis NN cord-269353-wgeuh1i2 150 6 : : : cord-269353-wgeuh1i2 150 7 virus virus NN cord-269353-wgeuh1i2 150 8 versus versus IN cord-269353-wgeuh1i2 150 9 host host NN cord-269353-wgeuh1i2 150 10 Codon Codon NNP cord-269353-wgeuh1i2 150 11 usage usage NN cord-269353-wgeuh1i2 150 12 bias bias NN cord-269353-wgeuh1i2 150 13 in in IN cord-269353-wgeuh1i2 150 14 the the DT cord-269353-wgeuh1i2 150 15 N n CD cord-269353-wgeuh1i2 150 16 gene gene NN cord-269353-wgeuh1i2 150 17 of of IN cord-269353-wgeuh1i2 150 18 rabies rabies NN cord-269353-wgeuh1i2 150 19 virus virus NN cord-269353-wgeuh1i2 150 20 Codon Codon NNP cord-269353-wgeuh1i2 150 21 usage usage NN cord-269353-wgeuh1i2 150 22 and and CC cord-269353-wgeuh1i2 150 23 tRNA trna NN cord-269353-wgeuh1i2 150 24 genes gene NNS cord-269353-wgeuh1i2 150 25 in in IN cord-269353-wgeuh1i2 150 26 eukaryotes eukaryote NNS cord-269353-wgeuh1i2 150 27 : : : cord-269353-wgeuh1i2 150 28 correlation correlation NN cord-269353-wgeuh1i2 150 29 of of IN cord-269353-wgeuh1i2 150 30 codon codon NN cord-269353-wgeuh1i2 150 31 usage usage NN cord-269353-wgeuh1i2 150 32 diversity diversity NN cord-269353-wgeuh1i2 150 33 with with IN cord-269353-wgeuh1i2 150 34 translation translation NN cord-269353-wgeuh1i2 150 35 efficiency efficiency NN cord-269353-wgeuh1i2 150 36 and and CC cord-269353-wgeuh1i2 150 37 with with IN cord-269353-wgeuh1i2 150 38 CG CG NNP cord-269353-wgeuh1i2 150 39 - - HYPH cord-269353-wgeuh1i2 150 40 dinucleotide dinucleotide NN cord-269353-wgeuh1i2 150 41 usage usage NN cord-269353-wgeuh1i2 150 42 as as IN cord-269353-wgeuh1i2 150 43 assessed assess VBN cord-269353-wgeuh1i2 150 44 by by IN cord-269353-wgeuh1i2 150 45 multivariate multivariate JJ cord-269353-wgeuh1i2 150 46 analysis analysis NN cord-269353-wgeuh1i2 150 47 Synthesis Synthesis NNP cord-269353-wgeuh1i2 150 48 of of IN cord-269353-wgeuh1i2 150 49 a a DT cord-269353-wgeuh1i2 150 50 new new JJ cord-269353-wgeuh1i2 150 51 Cre Cre NNP cord-269353-wgeuh1i2 150 52 recombinase recombinase NN cord-269353-wgeuh1i2 150 53 gene gene NN cord-269353-wgeuh1i2 150 54 based base VBN cord-269353-wgeuh1i2 150 55 on on IN cord-269353-wgeuh1i2 150 56 optimal optimal JJ cord-269353-wgeuh1i2 150 57 codon codon NN cord-269353-wgeuh1i2 150 58 usage usage NN cord-269353-wgeuh1i2 150 59 for for IN cord-269353-wgeuh1i2 150 60 mammalian mammalian JJ cord-269353-wgeuh1i2 150 61 systems system NNS cord-269353-wgeuh1i2 150 62 Revelation revelation NN cord-269353-wgeuh1i2 150 63 of of IN cord-269353-wgeuh1i2 150 64 influencing influence VBG cord-269353-wgeuh1i2 150 65 factors factor NNS cord-269353-wgeuh1i2 150 66 in in IN cord-269353-wgeuh1i2 150 67 overall overall JJ cord-269353-wgeuh1i2 150 68 codon codon NN cord-269353-wgeuh1i2 150 69 usage usage NN cord-269353-wgeuh1i2 150 70 bias bias NN cord-269353-wgeuh1i2 150 71 of of IN cord-269353-wgeuh1i2 150 72 equine equine JJ cord-269353-wgeuh1i2 150 73 influenza influenza NN cord-269353-wgeuh1i2 150 74 viruses virus NNS cord-269353-wgeuh1i2 150 75 Evolutionary evolutionary JJ cord-269353-wgeuh1i2 150 76 and and CC cord-269353-wgeuh1i2 150 77 genetic genetic JJ cord-269353-wgeuh1i2 150 78 analysis analysis NN cord-269353-wgeuh1i2 150 79 of of IN cord-269353-wgeuh1i2 150 80 the the DT cord-269353-wgeuh1i2 150 81 VP2 VP2 NNP cord-269353-wgeuh1i2 150 82 gene gene NN cord-269353-wgeuh1i2 150 83 of of IN cord-269353-wgeuh1i2 150 84 canine canine JJ cord-269353-wgeuh1i2 150 85 parvovirus parvovirus NN cord-269353-wgeuh1i2 150 86 A a DT cord-269353-wgeuh1i2 150 87 detailed detailed JJ cord-269353-wgeuh1i2 150 88 comparative comparative JJ cord-269353-wgeuh1i2 150 89 analysis analysis NN cord-269353-wgeuh1i2 150 90 on on IN cord-269353-wgeuh1i2 150 91 the the DT cord-269353-wgeuh1i2 150 92 overall overall JJ cord-269353-wgeuh1i2 150 93 codon codon NN cord-269353-wgeuh1i2 150 94 usage usage NN cord-269353-wgeuh1i2 150 95 patterns pattern NNS cord-269353-wgeuh1i2 150 96 in in IN cord-269353-wgeuh1i2 150 97 West West NNP cord-269353-wgeuh1i2 150 98 Nile Nile NNP cord-269353-wgeuh1i2 150 99 virus virus NN cord-269353-wgeuh1i2 150 100 Reduction reduction NN cord-269353-wgeuh1i2 150 101 of of IN cord-269353-wgeuh1i2 150 102 the the DT cord-269353-wgeuh1i2 150 103 rate rate NN cord-269353-wgeuh1i2 150 104 of of IN cord-269353-wgeuh1i2 150 105 poliovirus poliovirus NN cord-269353-wgeuh1i2 150 106 protein protein NN cord-269353-wgeuh1i2 150 107 synthesis synthesis NN cord-269353-wgeuh1i2 150 108 through through IN cord-269353-wgeuh1i2 150 109 large large JJ cord-269353-wgeuh1i2 150 110 - - HYPH cord-269353-wgeuh1i2 150 111 scale scale NN cord-269353-wgeuh1i2 150 112 codon codon NN cord-269353-wgeuh1i2 150 113 deoptimization deoptimization NN cord-269353-wgeuh1i2 150 114 causes cause VBZ cord-269353-wgeuh1i2 150 115 attenuation attenuation NN cord-269353-wgeuh1i2 150 116 of of IN cord-269353-wgeuh1i2 150 117 viral viral JJ cord-269353-wgeuh1i2 150 118 virulence virulence NN cord-269353-wgeuh1i2 150 119 by by IN cord-269353-wgeuh1i2 150 120 lowering lower VBG cord-269353-wgeuh1i2 150 121 specific specific JJ cord-269353-wgeuh1i2 150 122 infectivity infectivity NN cord-269353-wgeuh1i2 150 123 Quantitative quantitative JJ cord-269353-wgeuh1i2 150 124 effect effect NN cord-269353-wgeuh1i2 150 125 of of IN cord-269353-wgeuh1i2 150 126 suboptimal suboptimal JJ cord-269353-wgeuh1i2 150 127 codon codon NN cord-269353-wgeuh1i2 150 128 usage usage NN cord-269353-wgeuh1i2 150 129 on on IN cord-269353-wgeuh1i2 150 130 translational translational JJ cord-269353-wgeuh1i2 150 131 efficiency efficiency NN cord-269353-wgeuh1i2 150 132 of of IN cord-269353-wgeuh1i2 150 133 mRNA mrna NN cord-269353-wgeuh1i2 150 134 encoding encode VBG cord-269353-wgeuh1i2 150 135 HIV-1 HIV-1 NNP cord-269353-wgeuh1i2 150 136 gag gag NN cord-269353-wgeuh1i2 150 137 in in IN cord-269353-wgeuh1i2 150 138 intact intact JJ cord-269353-wgeuh1i2 150 139 T t NN cord-269353-wgeuh1i2 150 140 cells cell NNS cord-269353-wgeuh1i2 151 1 Synonymous synonymous JJ cord-269353-wgeuh1i2 151 2 but but CC cord-269353-wgeuh1i2 151 3 not not RB cord-269353-wgeuh1i2 151 4 the the DT cord-269353-wgeuh1i2 151 5 same same JJ cord-269353-wgeuh1i2 151 6 : : : cord-269353-wgeuh1i2 152 1 the the DT cord-269353-wgeuh1i2 152 2 causes cause NNS cord-269353-wgeuh1i2 152 3 and and CC cord-269353-wgeuh1i2 152 4 consequences consequence NNS cord-269353-wgeuh1i2 152 5 of of IN cord-269353-wgeuh1i2 152 6 codon codon NN cord-269353-wgeuh1i2 152 7 bias bias NN cord-269353-wgeuh1i2 152 8 OPTIMIZER OPTIMIZER NNP cord-269353-wgeuh1i2 152 9 : : : cord-269353-wgeuh1i2 152 10 a a DT cord-269353-wgeuh1i2 152 11 web web NN cord-269353-wgeuh1i2 152 12 server server NN cord-269353-wgeuh1i2 152 13 for for IN cord-269353-wgeuh1i2 152 14 optimizing optimize VBG cord-269353-wgeuh1i2 152 15 the the DT cord-269353-wgeuh1i2 152 16 codon codon NN cord-269353-wgeuh1i2 152 17 usage usage NN cord-269353-wgeuh1i2 152 18 of of IN cord-269353-wgeuh1i2 152 19 DNA dna NN cord-269353-wgeuh1i2 152 20 sequences sequence NNS cord-269353-wgeuh1i2 152 21 Analysis Analysis NNP cord-269353-wgeuh1i2 152 22 of of IN cord-269353-wgeuh1i2 152 23 codon codon NN cord-269353-wgeuh1i2 152 24 usage usage NN cord-269353-wgeuh1i2 152 25 bias bias NN cord-269353-wgeuh1i2 152 26 of of IN cord-269353-wgeuh1i2 152 27 Crimean Crimean NNP cord-269353-wgeuh1i2 152 28 - - HYPH cord-269353-wgeuh1i2 152 29 Congo Congo NNP cord-269353-wgeuh1i2 152 30 hemorrhagic hemorrhagic JJ cord-269353-wgeuh1i2 152 31 fever fever NN cord-269353-wgeuh1i2 152 32 virus virus NN cord-269353-wgeuh1i2 152 33 and and CC cord-269353-wgeuh1i2 152 34 its -PRON- PRP$ cord-269353-wgeuh1i2 152 35 adaptation adaptation NN cord-269353-wgeuh1i2 152 36 to to IN cord-269353-wgeuh1i2 152 37 hosts host NNS cord-269353-wgeuh1i2 152 38 Evolutionary evolutionary JJ cord-269353-wgeuh1i2 152 39 basis basis NN cord-269353-wgeuh1i2 152 40 of of IN cord-269353-wgeuh1i2 152 41 codon codon NN cord-269353-wgeuh1i2 152 42 usage usage NN cord-269353-wgeuh1i2 152 43 and and CC cord-269353-wgeuh1i2 152 44 nucleotide nucleotide JJ cord-269353-wgeuh1i2 152 45 composition composition NN cord-269353-wgeuh1i2 152 46 bias bias NN cord-269353-wgeuh1i2 152 47 in in IN cord-269353-wgeuh1i2 152 48 vertebrate vertebrate JJ cord-269353-wgeuh1i2 152 49 DNA dna NN cord-269353-wgeuh1i2 152 50 viruses virus NNS cord-269353-wgeuh1i2 152 51 Codon Codon NNP cord-269353-wgeuh1i2 152 52 usage usage NN cord-269353-wgeuh1i2 152 53 in in IN cord-269353-wgeuh1i2 152 54 regulatory regulatory JJ cord-269353-wgeuh1i2 152 55 genes gene NNS cord-269353-wgeuh1i2 152 56 in in IN cord-269353-wgeuh1i2 152 57 Escherichia Escherichia NNP cord-269353-wgeuh1i2 152 58 coli coli NNS cord-269353-wgeuh1i2 152 59 does do VBZ cord-269353-wgeuh1i2 152 60 not not RB cord-269353-wgeuh1i2 152 61 reflect reflect VB cord-269353-wgeuh1i2 152 62 selection selection NN cord-269353-wgeuh1i2 152 63 for for IN cord-269353-wgeuh1i2 152 64 ' ' `` cord-269353-wgeuh1i2 152 65 rare rare JJ cord-269353-wgeuh1i2 152 66 ' ' '' cord-269353-wgeuh1i2 152 67 codons codon NNS cord-269353-wgeuh1i2 152 68 Host host NN cord-269353-wgeuh1i2 152 69 influence influence NN cord-269353-wgeuh1i2 152 70 in in IN cord-269353-wgeuh1i2 152 71 the the DT cord-269353-wgeuh1i2 152 72 genomic genomic JJ cord-269353-wgeuh1i2 152 73 composition composition NN cord-269353-wgeuh1i2 152 74 of of IN cord-269353-wgeuh1i2 152 75 flaviviruses flavivirus NNS cord-269353-wgeuh1i2 152 76 : : : cord-269353-wgeuh1i2 152 77 a a DT cord-269353-wgeuh1i2 152 78 multivariate multivariate JJ cord-269353-wgeuh1i2 152 79 approach approach NN cord-269353-wgeuh1i2 152 80 Characterization characterization NN cord-269353-wgeuh1i2 152 81 of of IN cord-269353-wgeuh1i2 152 82 codon codon NN cord-269353-wgeuh1i2 152 83 usage usage NN cord-269353-wgeuh1i2 152 84 pattern pattern NN cord-269353-wgeuh1i2 152 85 and and CC cord-269353-wgeuh1i2 152 86 influencing influence VBG cord-269353-wgeuh1i2 152 87 factors factor NNS cord-269353-wgeuh1i2 152 88 in in IN cord-269353-wgeuh1i2 152 89 Japanese japanese JJ cord-269353-wgeuh1i2 152 90 encephalitis encephalitis JJ cord-269353-wgeuh1i2 152 91 virus virus NN cord-269353-wgeuh1i2 152 92 Synonymous synonymous JJ cord-269353-wgeuh1i2 152 93 codon codon NN cord-269353-wgeuh1i2 152 94 usage usage NN cord-269353-wgeuh1i2 152 95 in in IN cord-269353-wgeuh1i2 152 96 Escherichia Escherichia NNP cord-269353-wgeuh1i2 152 97 coli coli NNS cord-269353-wgeuh1i2 152 98 : : : cord-269353-wgeuh1i2 152 99 selection selection NN cord-269353-wgeuh1i2 152 100 for for IN cord-269353-wgeuh1i2 152 101 translational translational JJ cord-269353-wgeuh1i2 152 102 accuracy accuracy NN cord-269353-wgeuh1i2 153 1 Synonymous synonymous JJ cord-269353-wgeuh1i2 153 2 codon codon NN cord-269353-wgeuh1i2 153 3 usage usage NN cord-269353-wgeuh1i2 153 4 analysis analysis NN cord-269353-wgeuh1i2 153 5 of of IN cord-269353-wgeuh1i2 153 6 hand hand NN cord-269353-wgeuh1i2 153 7 , , , cord-269353-wgeuh1i2 153 8 foot foot NN cord-269353-wgeuh1i2 153 9 and and CC cord-269353-wgeuh1i2 153 10 mouth mouth NN cord-269353-wgeuh1i2 153 11 disease disease NN cord-269353-wgeuh1i2 153 12 viruses virus NNS cord-269353-wgeuh1i2 153 13 : : : cord-269353-wgeuh1i2 153 14 a a DT cord-269353-wgeuh1i2 153 15 comparative comparative JJ cord-269353-wgeuh1i2 153 16 study study NN cord-269353-wgeuh1i2 153 17 on on IN cord-269353-wgeuh1i2 153 18 coxsackievirus coxsackievirus NNP cord-269353-wgeuh1i2 153 19 A6 A6 NNP cord-269353-wgeuh1i2 153 20 , , , cord-269353-wgeuh1i2 153 21 A10 A10 NNP cord-269353-wgeuh1i2 153 22 , , , cord-269353-wgeuh1i2 153 23 A16 A16 NNP cord-269353-wgeuh1i2 153 24 , , , cord-269353-wgeuh1i2 153 25 and and CC cord-269353-wgeuh1i2 153 26 enterovirus enterovirus NN cord-269353-wgeuh1i2 153 27 71 71 CD cord-269353-wgeuh1i2 153 28 from from IN cord-269353-wgeuh1i2 153 29 Analysis Analysis NNP cord-269353-wgeuh1i2 153 30 of of IN cord-269353-wgeuh1i2 153 31 codon codon NN cord-269353-wgeuh1i2 153 32 usage usage NN cord-269353-wgeuh1i2 153 33 bias bias NN cord-269353-wgeuh1i2 153 34 and and CC cord-269353-wgeuh1i2 153 35 base base JJ cord-269353-wgeuh1i2 153 36 compositional compositional JJ cord-269353-wgeuh1i2 153 37 constraints constraint NNS cord-269353-wgeuh1i2 153 38 in in IN cord-269353-wgeuh1i2 153 39 iridovirus iridovirus NNP cord-269353-wgeuh1i2 153 40 genomes genome NNS cord-269353-wgeuh1i2 153 41 Analysis Analysis NNP cord-269353-wgeuh1i2 153 42 of of IN cord-269353-wgeuh1i2 153 43 codon codon NN cord-269353-wgeuh1i2 153 44 usage usage NN cord-269353-wgeuh1i2 153 45 in in IN cord-269353-wgeuh1i2 153 46 Newcastle Newcastle NNP cord-269353-wgeuh1i2 153 47 disease disease NN cord-269353-wgeuh1i2 153 48 virus virus NN cord-269353-wgeuh1i2 153 49 Codon Codon NNP cord-269353-wgeuh1i2 153 50 usage usage NN cord-269353-wgeuh1i2 153 51 bias bias NN cord-269353-wgeuh1i2 153 52 and and CC cord-269353-wgeuh1i2 153 53 the the DT cord-269353-wgeuh1i2 153 54 evolution evolution NN cord-269353-wgeuh1i2 153 55 of of IN cord-269353-wgeuh1i2 153 56 influenza influenza NN cord-269353-wgeuh1i2 153 57 A a DT cord-269353-wgeuh1i2 153 58 viruses virus NNS cord-269353-wgeuh1i2 153 59 . . . cord-269353-wgeuh1i2 154 1 Codon codon NN cord-269353-wgeuh1i2 154 2 usage usage NN cord-269353-wgeuh1i2 154 3 biases bias NNS cord-269353-wgeuh1i2 154 4 of of IN cord-269353-wgeuh1i2 154 5 influenza influenza NN cord-269353-wgeuh1i2 154 6 virus virus NN cord-269353-wgeuh1i2 155 1 The the DT cord-269353-wgeuh1i2 155 2 ' ' `` cord-269353-wgeuh1i2 155 3 effective effective JJ cord-269353-wgeuh1i2 155 4 number number NN cord-269353-wgeuh1i2 155 5 of of IN cord-269353-wgeuh1i2 155 6 codons codon NNS cord-269353-wgeuh1i2 155 7 ' ' POS cord-269353-wgeuh1i2 155 8 used use VBN cord-269353-wgeuh1i2 155 9 in in IN cord-269353-wgeuh1i2 155 10 a a DT cord-269353-wgeuh1i2 155 11 gene gene NN cord-269353-wgeuh1i2 155 12 Comparative comparative JJ cord-269353-wgeuh1i2 155 13 characterization characterization NN cord-269353-wgeuh1i2 155 14 analysis analysis NN cord-269353-wgeuh1i2 155 15 of of IN cord-269353-wgeuh1i2 155 16 synonymous synonymous JJ cord-269353-wgeuh1i2 155 17 codon codon NN cord-269353-wgeuh1i2 155 18 usage usage NN cord-269353-wgeuh1i2 155 19 bias bias NN cord-269353-wgeuh1i2 155 20 in in IN cord-269353-wgeuh1i2 155 21 classical classical JJ cord-269353-wgeuh1i2 155 22 swine swine NN cord-269353-wgeuh1i2 155 23 fever fever NN cord-269353-wgeuh1i2 155 24 virus virus NN cord-269353-wgeuh1i2 155 25 Analysis Analysis NNP cord-269353-wgeuh1i2 155 26 of of IN cord-269353-wgeuh1i2 155 27 the the DT cord-269353-wgeuh1i2 155 28 codon codon NN cord-269353-wgeuh1i2 155 29 usage usage NN cord-269353-wgeuh1i2 155 30 of of IN cord-269353-wgeuh1i2 155 31 the the DT cord-269353-wgeuh1i2 155 32 ORF2 ORF2 NNP cord-269353-wgeuh1i2 155 33 gene gene NN cord-269353-wgeuh1i2 155 34 of of IN cord-269353-wgeuh1i2 155 35 feline feline JJ cord-269353-wgeuh1i2 155 36 calicivirus calicivirus NNP cord-269353-wgeuh1i2 155 37 Analysis Analysis NNP cord-269353-wgeuh1i2 155 38 of of IN cord-269353-wgeuh1i2 155 39 codon codon NN cord-269353-wgeuh1i2 155 40 usage usage NN cord-269353-wgeuh1i2 155 41 bias bias NN cord-269353-wgeuh1i2 155 42 of of IN cord-269353-wgeuh1i2 155 43 envelope envelope NN cord-269353-wgeuh1i2 155 44 glycoprotein glycoprotein NN cord-269353-wgeuh1i2 155 45 genes gene NNS cord-269353-wgeuh1i2 155 46 in in IN cord-269353-wgeuh1i2 155 47 nuclear nuclear JJ cord-269353-wgeuh1i2 155 48 polyhedrosis polyhedrosis NN cord-269353-wgeuh1i2 155 49 virus virus NN cord-269353-wgeuh1i2 155 50 ( ( -LRB- cord-269353-wgeuh1i2 155 51 NPV NPV NNP cord-269353-wgeuh1i2 155 52 ) ) -RRB- cord-269353-wgeuh1i2 155 53 and and CC cord-269353-wgeuh1i2 155 54 its -PRON- PRP$ cord-269353-wgeuh1i2 155 55 relation relation NN cord-269353-wgeuh1i2 155 56 to to IN cord-269353-wgeuh1i2 155 57 evolution evolution NN cord-269353-wgeuh1i2 156 1 The the DT cord-269353-wgeuh1i2 156 2 distribution distribution NN cord-269353-wgeuh1i2 156 3 of of IN cord-269353-wgeuh1i2 156 4 synonymous synonymous JJ cord-269353-wgeuh1i2 156 5 codon codon NN cord-269353-wgeuh1i2 156 6 choice choice NN cord-269353-wgeuh1i2 156 7 in in IN cord-269353-wgeuh1i2 156 8 the the DT cord-269353-wgeuh1i2 156 9 translation translation NN cord-269353-wgeuh1i2 156 10 initiation initiation NN cord-269353-wgeuh1i2 156 11 region region NN cord-269353-wgeuh1i2 156 12 of of IN cord-269353-wgeuh1i2 156 13 dengue dengue NN cord-269353-wgeuh1i2 156 14 virus virus NN cord-269353-wgeuh1i2 156 15 Codon Codon NNP cord-269353-wgeuh1i2 156 16 usage usage NN cord-269353-wgeuh1i2 156 17 is be VBZ cord-269353-wgeuh1i2 156 18 an an DT cord-269353-wgeuh1i2 156 19 important important JJ cord-269353-wgeuh1i2 156 20 determinant determinant NN cord-269353-wgeuh1i2 156 21 of of IN cord-269353-wgeuh1i2 156 22 gene gene NN cord-269353-wgeuh1i2 156 23 expression expression NN cord-269353-wgeuh1i2 156 24 levels level NNS cord-269353-wgeuh1i2 156 25 largely largely RB cord-269353-wgeuh1i2 156 26 through through IN cord-269353-wgeuh1i2 156 27 its -PRON- PRP$ cord-269353-wgeuh1i2 156 28 effects effect NNS cord-269353-wgeuh1i2 156 29 on on IN cord-269353-wgeuh1i2 156 30 transcription transcription NN cord-269353-wgeuh1i2 157 1 This this DT cord-269353-wgeuh1i2 157 2 work work NN cord-269353-wgeuh1i2 157 3 was be VBD cord-269353-wgeuh1i2 157 4 supported support VBN cord-269353-wgeuh1i2 157 5 by by IN cord-269353-wgeuh1i2 157 6 Guangdong Guangdong NNP cord-269353-wgeuh1i2 157 7 Natural Natural NNP cord-269353-wgeuh1i2 157 8 Science Science NNP cord-269353-wgeuh1i2 157 9 Funds Funds NNPS cord-269353-wgeuh1i2 157 10 for for IN cord-269353-wgeuh1i2 157 11 Distinguished Distinguished NNP cord-269353-wgeuh1i2 157 12 Young Young NNP cord-269353-wgeuh1i2 157 13 Scholar scholar NN cord-269353-wgeuh1i2 157 14 ( ( -LRB- cord-269353-wgeuh1i2 157 15 2014A030306046 2014a030306046 CD cord-269353-wgeuh1i2 157 16 ) ) -RRB- cord-269353-wgeuh1i2 157 17 . . .