id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302679-wytog9cv	Panda, Somnath	Bioinformatics analysis reveals four major hexon variants of human adenovirus type-3 (HAdV-3) as the potential strains for development of vaccine and siRNA-based therapeutics against HAdV-3 respiratory infections	2020-06-23		.txt	text/plain	2178	143	54	title: Bioinformatics analysis reveals four major hexon variants of human adenovirus type-3 (HAdV-3) as the potential strains for development of vaccine and siRNA-based therapeutics against HAdV-3 respiratory infections Then, we have identified the conserved locations in HVR encoding regions of the hexon gene and fr om those locations we have designed functional siRNAs. Next, we have also designed immunogenic vaccine peptide epitopes from the hexon protein that can be used to design a vaccine. The variations among the HVR encoding regions of the hexon gene of 3Hv-1 to 3Hv-4 were shown by multi-sequence alignment (MSA), in silico RE analysis Numerous tools are available to design functional siRNAs such as MysiRNA-designer [22] , siDirect [23] and siMAX-siRNA Designer (https://eurofinsgenomics.eu/en/dnarna-oligonucleotides/custom-dna-rna-oligos/simax-sirna/) etc. We have designed functional siRNAs from those conserved regions and immunogenic vaccine peptide epitopes from the hexon protein.	./cache/cord-302679-wytog9cv.txt	./txt/cord-302679-wytog9cv.txt