id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253090-kllrqoxi	dos Passos Cunha, Marielton	Codon adaptation biases among sylvatic and urban genotypes of Dengue virus type 2	2018-05-21		.txt	text/plain	3283	207	49	Dengue virus (DENV) emerged from the sylvatic environment and colonized urban settings, being sustained in a human-Aedes-human transmission chain, mainly by the bites of females of the anthropophilic species Aedes aegypti. In this context, as previous analyses have suggested (Moncayo et al., 2004) , our findings support the notion that for the sylvatic strains to effectively colonize the urban environment, the virus needs a number of silent, adaptive nucleotide substitutions to optimize the codon usage to invertebrate host cells, while maintaining a compositional base balance suitable for efficient alternate spread among both human and insect hosts. In conclusion, our findings provide a comprehensive assessment of the codon adaptation of DENV-2 in different habitats (i.e. urban and sylvatic settings) and host systems (i.e. Homo sapiens and the mosquito vector Aedes aegypti). In this context, although the virus replicates in both human and mosquitoes, our analysis suggested that DENV-2 codon usage is better adapted to humans than to the main cosmopolitan vector (Ae. aegypti).	./cache/cord-253090-kllrqoxi.txt	./txt/cord-253090-kllrqoxi.txt