cord-006788-kz8i4a6h	2019	In expression tissues, metabolic FGF genes are subject to direct transcriptional control by several major metabolite-responsive nuclear receptors, including farnesoid X receptor (FXR), peroxisome proliferator-activated receptor α (PPARA) and γ (PPARG), carbohydrate-response element-binding protein (Ch-REBP), sterol regulatory element-binding protein-1c (SREBP1c), retinoic acid-related orphan receptor α (RORA), liver X receptor β (LXRB), vitamin D receptor (VDR) [48] [49] [50] [57] [58] [59] [60] [61] [62] [63] [64] [65] , and stress-sensing transcription factors, such as ATF4 [66] , depending on the location of specific nutrition/energy-sensing cells in specific tissues. The hepatic and pharmacological FGF21 drive multiple signal axes in multiple tissues/organs, resulting in multifaceted beneficiary metabolic effects, including promoting (green arrow) glucose, lipid, and energy homeostasis; offsetting metabolic derangements; and preventing (red long-tailed "T" sign) metaflammation, inflammatory tissue damage, and tissue-specific pathogenesis, including obesity, type 2 diabetes, fatty liver disease, metabolic syndrome, and associated comorbidities.
cord-253452-feb75ei4	2017	To discuss the current situation and trend of geo-authentic Lonicerae Japonicae Flos, we searched Chinese Biomedicine Literature Database, Chinese Journal Full-text Database, Chinese Scientific Journal Full-text Database, Cochrane Central Register of Controlled Trials, Wanfang, and PubMed. We investigated all studies up to November 2015 pertaining to quality assessment, discrimination, pharmacological effects, planting or processing, or ecological system of geo-authentic Lonicerae Japonicae Flos. The table included the basic information of articles and the main information about geo-authentic Lonicerae Japonicae Flos, such as chemical fingerprint, component, discrimination, pharmacological effects, planting, and processing. All of these studies were classified into 6 parts, based on the main idea of articles, mainly discussing the following points: chemical fingerprint, component analysis, planting and processing, ecological system, pharmacological effects and safety, and discrimination between different varieties. Briefly, research shows that geo-authentic Lonicerae Japonicae Flos is mainly characterized by chemical fingerprint, component analysis, planting and processing, discrimination between varieties, ecological system, pharmacological effects, and safety and focuses on the quality assessment technology.
cord-274477-jkjyh4cs	2020	The outbreak of a novel Coronavirus disease (COVID-19, caused by the 2019-nCoV infection) in December 2019 is one of the most severe public health emergencies since the founding of People''s Republic of China in 1949. Healthcare personnel (HCP) nationwide are facing heavy workloads and high risk of infection, especially those who care for patients at the epicenter of the outbreak, Hubei Province. Based on literature search and interviews with some HCP working at Wuhan, capital city of Hubei, we have summarized some of the effective measures taken to reduce infection among HCP, and also made suggestions for improving occupational safety during an infectious disease outbreak. The local outbreak of novel coronavirus epidemic (COVID-19, caused by the 2019-nCoV infection) in Wuhan, Hubei Province of China, last December has rapidly spread nationwide with a cumulative number of 80 026 laboratory-confirmed cases and 2912 deaths as of March 1, 2020 [1] .
cord-287222-wojyisu0	2020	Of the first 99 laboratory-confirmed patients, 49 (49%) had been exposed to HSWM, which was reported to be the possible initial source of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) [5] . New Coronavirus Infection Diagnosis and Treatment Scheme (Trial Version) published by Military Support Hubei Medical Team also put forward that for mild to moderate COVID-19 patients, corticosteroids should not be given principally and highdose corticosteroid pulse therapy was not recommended. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Clinical pathology of critical patient with novel coronavirus pneumonia (COVID-19)
cord-307995-8q7efrqk	2016	Middle East respiratory syndrome coronavirus (MERS-CoV): summary and risk assessment of current situation in the Republic of Korea and China -as of 19 Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study A family cluster of Middle East Respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study KSA MERS-CoV Investigation Team.Hospital outbreak of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study
cord-308673-dkmpayk4	2020	Here we report the first family case of coronavirus disease 2019 (COVID-19) confirmed in Wuhan and treated using the combination of western medicine and Chinese traditional patent medicine Shuanghuanglian oral liquid (SHL). The present report described a family case, including three cases who received western medicine and Chinese traditional patent medicine Shuanghuanglian oral liquid (SHL) treatments and achieved rapid recovery. On January 28, the patient was diagnosed of COVID-19 with positive 2019-nCoV test using nasopharyngeal swab specimen (Table 1 ) and chest CT scan showing patchy ground glass opacity in the right lower lung subpleural fields (Fig. 4) . This report described the first typical family case of COVID-19 treated using the Chinese traditional patent medicine SHL because of poor response to other treatments. All their symptoms resolved after using the Chinese traditional patent medicine SHL and rapidly recovered without obvious adverse effects when the patients showed no response and their symptoms continued to aggravate after other treatments, including IVIG (5 g per day) and dexamethasone, antibiotics, and antivirus compounds.
cord-310331-29srzbuk	2020	Armed with experience from previous epidemics in the last two decades, clinicians, scientists, officials, and citizens in China are all contributing to the prevention of further 2019-nCoV transmission. The 2019 novel coronavirus (2019-nCoV) outbreak is currently bringing challenges to China and the whole world. Since direct human transmission and asymptomatic infection have been revealed for 2019-nCoV [3] , health authorities in China are facing an enormous challenge on disease management and control. Realizing the severity of SARS-CoV as a respiratory virus, the detection of pneumonia of unknown origin in 2019-nCoV outbreak enabled relatively early alarm from health authorities and raised awareness for medical staff to equip personal protection methods when dealing with suspected cases. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
cord-312361-ermbijfq	2020	The COVID-19 caused by a novel strain of Coronavirus has been spreading rapidly since its onset in Wuhan, the capital city of central China''s Hubei Province, in December 2019. A novel strain of coronavirus has caused a pneumonia outbreak in the central Chinese city of Wuhan since December 2019 and has been quickly spreading to other parts of China. The two makeshift hospitals are playing major roles in improving the cure rate and decreasing the death rate of infected patients and help China and the world win the combat of prevention against and control of this growing epidemic situation. Similar mass mobilization and harsh measures are under way in severely affected areas in China to ensure the health and safety of people, both Chinese and internationals, and the effective prevention and control of this epidemic for the shared well-being of mankind.
cord-330198-pwkxgbxk	2020	All febrile or suspected COVID-19 cases were referred to the fever clinic, and the others-including critically ill children-were received by the emergency department after pediatric 5-level triage. We retrospectively analyzed the clinical data of these children admitted from the emergency department to characterize thoroughly the features of COVID-19 that can be evaluated to distinguish this novel disease from pneumonia caused by other pathogens in pediatric patients. Owing to the parents'' fear that their children were infected with SARS-CoV-2, the median time from symptom onset to hospital admission was shorter for confirmed COVID-19 cases (2.0 days) than that for suspected COVID-19 cases (3.0 days) and non-COVID-19 cases (4.0 days) (P < 0.05). Moreover, serologic testing can serve as an important adjunctive method for COVID-19 diagnosis, especially when the patient is highly suspected of SARS-CoV-2 infection but is found to be negative by nucleic acid testing.
cord-331228-wbd0s4fo	2016	authors: Shehata, Mahmoud M.; Gomaa, Mokhtar R.; Ali, Mohamed A.; Kayali, Ghazi Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation Middle East respiratory syndrome coronavirus (MERS-CoV)-Saudi Arabia Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study First cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infections in France, investigations and implications for the prevention of human-to-human transmission Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia
cord-338258-bdyalfcd	2013	title: The first avian influenza A (H7N9) viral infection in humans in Zhejiang Province, China: a death report This study reports the first death caused by a novel avian influenza A (H7N9) virus in Zhejiang Province, China. This report is important for assessing and controlling similar cases, and would provide meaningful insights into the early and rapid diagnosis, treatment, prevention, and control of human influenza A (H7N9) viral infections. According to the updated data from 131 cases and 32 deaths, the novel influenza A (H7N9) virus circulating in the urban and rural areas of Beijing and Shanghai, as well as Anhui, Jiangsu, Zhejiang, etc., differs from the avian H5N1 reported in rural areas [15] . About 65% of the confirmed cases had histories of avian exposure, which indicates that contact with live poultry and excreta is a high-risk factor, similar to the H5N1 virus infection in China [17, 18] .
cord-344480-6tcush4w	2020	The updated genome sequence of SARS-CoV-2 has been shared to the public, clinical trials are undergoing, and scientists from China and overseas are working together to combat this public health emergency. Epidemiological research priorities for public health control of the ongoing global novel coronavirus (2019-nCoV) outbreak The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China.
cord-347414-t88654wo	2020	title: Successful management of seven cases of critical COVID-19 with early noninvasive-invasive sequential ventilation algorithm and bundle pharmacotherapy We report the clinical and laboratory findings and successful management of seven patients with critical coronavirus disease 2019 (COVID-19) requiring mechanical ventilation (MV). Upon diagnosis with COVID-19 of critical severity, the patients were admitted to the intensive care unit, where they received early noninvasive–invasive sequential ventilation, early prone positioning, and bundle pharmacotherapy regimen, which consists of antiviral, anti-inflammation, immune-enhancing, and complication-prophylaxis medicines. Here, we report the successful management of seven critically ill patients diagnosed with COVID-19 who suffered acute respiratory failure. Good treatment outcomes can be achieved for critically ill patients with COVID-19 with early sequential noninvasive-invasive ventilation and bundle pharmacotherapy, which comprises antiviral and anti-inflammation medicines, immune system support, and prophylaxis for vascular complications.