id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006788-kz8i4a6h	Li, Xiaokun	The FGF metabolic axis	2019-09-07		.txt	text/plain	9322	404	33	In expression tissues, metabolic FGF genes are subject to direct transcriptional control by several major metabolite-responsive nuclear receptors, including farnesoid X receptor (FXR), peroxisome proliferator-activated receptor α (PPARA) and γ (PPARG), carbohydrate-response element-binding protein (Ch-REBP), sterol regulatory element-binding protein-1c (SREBP1c), retinoic acid-related orphan receptor α (RORA), liver X receptor β (LXRB), vitamin D receptor (VDR) [48] [49] [50] [57] [58] [59] [60] [61] [62] [63] [64] [65] , and stress-sensing transcription factors, such as ATF4 [66] , depending on the location of specific nutrition/energy-sensing cells in specific tissues. The hepatic and pharmacological FGF21 drive multiple signal axes in multiple tissues/organs, resulting in multifaceted beneficiary metabolic effects, including promoting (green arrow) glucose, lipid, and energy homeostasis; offsetting metabolic derangements; and preventing (red long-tailed "T" sign) metaflammation, inflammatory tissue damage, and tissue-specific pathogenesis, including obesity, type 2 diabetes, fatty liver disease, metabolic syndrome, and associated comorbidities.	./cache/cord-006788-kz8i4a6h.txt	./txt/cord-006788-kz8i4a6h.txt