id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349958-126yb5se	Raskin, Jo	CANCER IN THE TIME OF COVID: Expert opinion on how to adapt current practice	2020-04-16		.txt	text/plain	1590	121	51	 Standard of care in most patients is chemoradiotherapy with 4 cycles of cisplatin/etoposide as preferred chemotherapy regimen.  Replacing intravenous with oral etoposide to reduce time-in-hospital should be weighed against its lower biological availability and variable pharmacodynamics in a curative setting [6]  In patients with stage I SCLC surgical resection of the tumour, followed by adjuvant chemotherapy (4 cycles of cisplatin/etoposide) is indicated.  Consider giving cisplatin/pemetrexed instead of cisplatin/etoposide, or weekly carboplatin/paclitaxel in non-squamous NSCLC to limit time-in-hospital [9] .  Evaluate the indication for palliative chemotherapy, immunotherapy or both with extra care in elderly patients or patients with significant comorbidity, decreased performance (PS ≥2), social isolation, decubitus, urinary catheters, … especially in second or further lines [3] .  Consider limiting palliative chemotherapy to 4 cycles and omitting pemetrexed maintenance therapy [3] .  Palliative chemotherapy with 4 cycles of platinum/pemetrexed is recommended in all other cases of PS 0-1 patients.	./cache/cord-349958-126yb5se.txt	./txt/cord-349958-126yb5se.txt