id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335198-qp964238	Kotsimbos, T.	Pandemic Treatments on Trial: The bigger picture	2020-08-03		.txt	text/plain	2727	134	44	Given the stated extremes above, there is a clear trade-off between "doing all that one can for individual patients with currently available information in a timely manner and despite significant uncertainty" and "group treatment of individuals to be enrolled in properly conducted but costly (effort, time and money) clinical trials for specific therapeutic approaches that will help inform the evidence-base for future patients". And how do we quickly establish and conduct difficult and costly randomized, controlled clinical trials for the most promising old and new therapies where there is a clear equipoise between possible benefits and potential risks? Paradoxically, the almost immediate establishment of a well-designed RCT to test the combination antiviral treatment lopinavir-ritonavir in Wuhan, China during the beginning of the pandemic exemplified this tension in a most unusual way when trial recruitment ceased early due to falling COVID19 case numbers (7).	./cache/cord-335198-qp964238.txt	./txt/cord-335198-qp964238.txt