id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-290671-6p23qxb8	Jiang, Shibo	An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies	2020-01-31		.txt	text/plain	1113	55	45	We have recently designed and engineered a pan-CoV fusion inhibitor, EK1 peptide, which could inhibit infection of five human coronaviruses, including SARS-CoV and MERS-CoV, and three bat-SL-CoVs [7] . Intranasal application of EK1 peptide before or after viral challenge, EK1 peptide can protect human DPP4-transgenic mice from MERS-CoV infection, suggesting its potential prophylactic and therapeutic effect against 2019-nCoV infection. The recently developed SARS-CoV and MERS-CoV neutralizing monoclonal antibodies (mAbs) and nanobodies with protective efficacy are specific to the S1 subunit of S protein, particularly the RBD [5, [8] [9] [10] . One of the rapid approaches is to evaluate the currently available SARS-CoV neutralizing antibodies with cross-neutralizing and protection activity against 2019-nCoV infection. The spike protein of SARS-CoV-a target for vaccine and therapeutic development A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein	./cache/cord-290671-6p23qxb8.txt	./txt/cord-290671-6p23qxb8.txt