id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-336384-sollv92j	Goren, Andy	What does androgenetic alopecia have to do with COVID‐19? An insight into a potential new therapy	2020-04-08		.txt	text/plain	885	57	35	4 In animal studies, it was demonstrated that a sexual dimorphism in fetal pulmonary surfactant production is influenced by the androgen receptor (AR). 5 For example, in rabbits, dihydrotestosterone was shown to inhibit fetal pulmonary surfactant production in both males and females while an anti-androgen, flutamide, was demonstrated to remove the sexual dimorphism in surfactant production. 9, 10 Additional evidence to the possible implication of androgens in COVID-19 infection severity is found in the molecular mechanism required for SARS-CoV-2 infectivity. 11 Previously, it was demonstrated that SARS-CoV-2 cell entry depends on priming of a viral spike surface protein by transmembrane protease serine 2 (TMPRSS2) present in the host. Dihydrotestosterone (DHT) a potent androgen receptor activator and is intracellularly produced in particular cells of tissues such as prostate, hair, and liver that express 5-alpha-reductases, the targeted enzyme for drugs such as dutasteride and finasteride (5-alphareductase inhibitors)	./cache/cord-336384-sollv92j.txt	./txt/cord-336384-sollv92j.txt