id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-284158-5qvq27hu	Abdelmaksoud, Ayman	Systemic isotretinoin therapy in the era of COVID‐19	2020-05-20		.txt	text/plain	998	63	39	Olfactory epithelium non-neural cell types express two host receptors, ACE2 and type 2 transmembrane serine protease (TMPRSS2), that facilitate SARS-CoV-2 replication and accumulation, and subsequently central nervous system invasion which may lead to respiratory failure of COVID-19 patients. 14 Lechien et al noted that 85.6% of their patients had olfactory dysfunction (79.6% were anosmic and 20.4% were hyposmic) related to COVID-19 infection, with no significant associated rhinorrhea or nasal obstruction. 19 In nutshell, till further studies on the multifaceted pathogenesis of COVID-19 infection, we suggest low, lid-dose of isotretinoin with folic acid supplement, together with proper nasal mucosal care for isotretinoin patients. Isotretinoin treatment should be questioned in all COVID-19 suspected patients presented with nasal/olfactory dysfunction symptoms. Effect of systemic isotretinoin therapy on mucociliary clearance and nasal surface mucosa in acne patients Effects of isotretinoin on the olfactory function in patients with acne	./cache/cord-284158-5qvq27hu.txt	./txt/cord-284158-5qvq27hu.txt