id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302786-ibt7mupq	Suwanwongse, Kulachanya	Fatal Outcome in a Kidney-Pancreas Transplant Recipient With COVID-19	2020-06-18		.txt	text/plain	2229	138	47	Despite a growing report on clinical characteristics and prognosis of patients with COVID-19, the data in the special population, including transplant recipients, is still limited. We proposed that the pre-existing T-cell dysfunction from the long-term use of immunosuppressive agents in organ transplant recipients adversely affects COVID-19 prognosis and worsens COVID-19 mortality. However, impaired immune functions may paradoxically protect transplant patients from the hyper-inflammatory response to SARS-CoV-2 and thus dampen the disease severity. Long-term immunosuppressive therapy in organ transplant recipients may alter clinical features and outcomes of COVID-19. The long-term use of immunosuppressive medications in organ transplant recipients is associated with the decrease in T-cell number and function; TAC and MMF preferentially inhibit T-cell response. However, in this report, immunosuppressive agents were discontinued in patients with severe disease, presumably with high mortality risks. Preexisting T-cell immune response deficits from long-term use of immunosuppressive agents may worsen the prognosis of COVID-19 in transplant recipients.	./cache/cord-302786-ibt7mupq.txt	./txt/cord-302786-ibt7mupq.txt